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Slide 171: Well Differentiated
Squamous Cell Carcinoma of the
Penis
Gross: Starts as an
pearly papule
This is a squamous cell carcinoma of
the penis (penectomy specimen) that
is a larger reddish brown fungating
mass.
Histology:
Appears as an invading tumor
with marked parakeratosis
Nest and sheets of malignant
epithelial cells that invades
the underlying stoma
Desmoplastic stroma
infiltrated with inflammatory
cells, predominantly
lymphocytes
Pleomorphism,
hyperchromasia of the nuclei,
and presence of mitotic
figures.
Adequate cytoplasm
Intercellular bridges
Keratin pearls
**keratin pearl at the pointer
**Well Differentiated SCC, Penis
Slide 1: Seminoma of the Testis
Gross:
Well circumscribed firm mass
Grayish white, bulging cut
surface
No hemorrhage
No necrosis
Histology:
Sheets of polyhedral cells
divided into indistinct lobules
Scanty fibrous stroma with
lymphocytic infiltrate and few
seminiferous tubules
POLYHEDRAL CELLS- prominent
nucleoli with pink or clear
cytoplasm
Subject: Patho LabTopic: MGS Pre LabLecturer:Date of Lecture: Nov. 16, 2011
Transcriptionist: GluttonoidsPages: 4
S
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2011-2
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2011-2
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8/3/2019 Patholab Mgs Prelab Tranx
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Normal testis appears at the left,
and seminoma is present at the
right. Note the difference in size
and staining quality of the
neoplastic nests of cells compared
to normal germ cells. Note the
lymphoid stroma between the
nests of seminoma.
Slide 12: Choriocarcinoma, Testis
Gross:
Enlarged rubbery to firm
testis
8.5x802x8.0 cm.
Hemorrhagic cut surface
with evident necrosis
Histology:
CYTOTROPHOBLAST -
Polyhedral cells with large
nuclei prominent nucleoli and
with pink cytoplasm)
SYNCITIOTROPHOBLAST- dark
staining, multinucleated cells,
or appears as Sheet of cells
(acc. To Dra. Dela Fuente)
Intermediate trophoblasta
features intermediate
between cytotrophoblasts and
syncytiotrophoblast
Prominent Hemorrhage and
wide bands of fibrous tissue
c- Cytotrophoblast; S-
syncitiotrophoblast
Slide 26: Nodular Hyperplasia of
the Prostate
Characteristic:
Benign Frequent scanty urination
Difficulty in initiating urination
Post voidal retention
Nocturia
Gross:
Markedly enlarged and
nodular middle lobe
honey combed
appearance nodular and
cystic dilation of the surface
C
S
C
S
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Histology:
Hyperplasia of both glandular
and fibromuscular elements
Glands are variable in sizes
and shapes (dilated or wirh
papillomatous folds)
CORPORA AMYLACEA- pinkconcentric bodies in cystic
spaces
(HPO)
This is the microscopic appearance of
nodular prostatic hyperplasia at low
magnification. Note the nodule filled
with enlarged glands. Though
crowded, there is still stroma between
the glands.
Benign prostate gland with basal cell
and secretory cell layer
Slide 176: Moderately
Differentiated Adenocarcinoma,
Prostate
Clinical Features: Frequent scanty urination
Painless hematuria
Gross:
25 g
Light brown
Ill defined mass with clean
white cut surface
Rubbery to firm prostatic
chips
Histology:
Gleason Grade 5: tumor cells
are nest, sheets, trabeculae
of invading fibromuscular
stroma
Gleason Grade 4: tumor cells
are closely packed gland
Gleason Grade 3: separated
by fibrous stroma
Adenocarcinoma of the prostate isshown here at low power on the left,compared to benign prostate (in whichglands contain corpora amylacea) atthe right. Note how small and close-packed the neoplastic glands are
Corpora Amylacea
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Adenocarcinoma of the prostate isshown here at medium power. Someof the neoplastic glands have lumens,but there is no stroma between
A hallmark of prostaticadenocarcinoma is the presence ofprominent large nucleoli, as seen
here. (HPO)-
Low grade (Gleason score: 1 +1 =2) almost uniform sized malignant glands
Moderately differentiated Gleason
score: 3+3 = 6
Gleason (5+5 =10) poorly
differentiated/High Grade
Adenocarcinoma.
Cryptorchidism
Testicular atrophy in cryptorchidism.
The tubules show Sertoli cells but nospermatogenesis. There is thickening
of basement membranes and an
apparent increase in interstitial Leydig
cells
Embryonal Carcinoma
Embryonal carcinoma shows sheets of
undifferentiated cells as well as
primitive glandular differentiation. The
nuclei are large and hyperchromatic.
Yolk Sac Tumor
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Yolk sac tumor of the testis is shown
composed of primitive germ cells that
form glomeruloid or embryonal-like
structures. These tumors are most
frequent in children, but overall they
are rare.
Schiller-Duval body is a structure seen
in the endodermal sinus pattern of
yolk sac tumor.
Teratoma
Teratoma of the testis consisting of a
disorganized collection of glands,
cartilage, smooth muscle, and
immature stroma.
***End of Transcription***
Some helpful sites:
http://library.med.utah.edu/WebPath
http://webpathology.com