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Patholab Mgs Prelab Tranx

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    Slide 171: Well Differentiated

    Squamous Cell Carcinoma of the

    Penis

    Gross: Starts as an

    pearly papule

    This is a squamous cell carcinoma of

    the penis (penectomy specimen) that

    is a larger reddish brown fungating

    mass.

    Histology:

    Appears as an invading tumor

    with marked parakeratosis

    Nest and sheets of malignant

    epithelial cells that invades

    the underlying stoma

    Desmoplastic stroma

    infiltrated with inflammatory

    cells, predominantly

    lymphocytes

    Pleomorphism,

    hyperchromasia of the nuclei,

    and presence of mitotic

    figures.

    Adequate cytoplasm

    Intercellular bridges

    Keratin pearls

    **keratin pearl at the pointer

    **Well Differentiated SCC, Penis

    Slide 1: Seminoma of the Testis

    Gross:

    Well circumscribed firm mass

    Grayish white, bulging cut

    surface

    No hemorrhage

    No necrosis

    Histology:

    Sheets of polyhedral cells

    divided into indistinct lobules

    Scanty fibrous stroma with

    lymphocytic infiltrate and few

    seminiferous tubules

    POLYHEDRAL CELLS- prominent

    nucleoli with pink or clear

    cytoplasm

    Subject: Patho LabTopic: MGS Pre LabLecturer:Date of Lecture: Nov. 16, 2011

    Transcriptionist: GluttonoidsPages: 4

    S

    Y

    2011-2

    012

    SY

    2011-2

    012

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    Normal testis appears at the left,

    and seminoma is present at the

    right. Note the difference in size

    and staining quality of the

    neoplastic nests of cells compared

    to normal germ cells. Note the

    lymphoid stroma between the

    nests of seminoma.

    Slide 12: Choriocarcinoma, Testis

    Gross:

    Enlarged rubbery to firm

    testis

    8.5x802x8.0 cm.

    Hemorrhagic cut surface

    with evident necrosis

    Histology:

    CYTOTROPHOBLAST -

    Polyhedral cells with large

    nuclei prominent nucleoli and

    with pink cytoplasm)

    SYNCITIOTROPHOBLAST- dark

    staining, multinucleated cells,

    or appears as Sheet of cells

    (acc. To Dra. Dela Fuente)

    Intermediate trophoblasta

    features intermediate

    between cytotrophoblasts and

    syncytiotrophoblast

    Prominent Hemorrhage and

    wide bands of fibrous tissue

    c- Cytotrophoblast; S-

    syncitiotrophoblast

    Slide 26: Nodular Hyperplasia of

    the Prostate

    Characteristic:

    Benign Frequent scanty urination

    Difficulty in initiating urination

    Post voidal retention

    Nocturia

    Gross:

    Markedly enlarged and

    nodular middle lobe

    honey combed

    appearance nodular and

    cystic dilation of the surface

    C

    S

    C

    S

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    Histology:

    Hyperplasia of both glandular

    and fibromuscular elements

    Glands are variable in sizes

    and shapes (dilated or wirh

    papillomatous folds)

    CORPORA AMYLACEA- pinkconcentric bodies in cystic

    spaces

    (HPO)

    This is the microscopic appearance of

    nodular prostatic hyperplasia at low

    magnification. Note the nodule filled

    with enlarged glands. Though

    crowded, there is still stroma between

    the glands.

    Benign prostate gland with basal cell

    and secretory cell layer

    Slide 176: Moderately

    Differentiated Adenocarcinoma,

    Prostate

    Clinical Features: Frequent scanty urination

    Painless hematuria

    Gross:

    25 g

    Light brown

    Ill defined mass with clean

    white cut surface

    Rubbery to firm prostatic

    chips

    Histology:

    Gleason Grade 5: tumor cells

    are nest, sheets, trabeculae

    of invading fibromuscular

    stroma

    Gleason Grade 4: tumor cells

    are closely packed gland

    Gleason Grade 3: separated

    by fibrous stroma

    Adenocarcinoma of the prostate isshown here at low power on the left,compared to benign prostate (in whichglands contain corpora amylacea) atthe right. Note how small and close-packed the neoplastic glands are

    Corpora Amylacea

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    Adenocarcinoma of the prostate isshown here at medium power. Someof the neoplastic glands have lumens,but there is no stroma between

    A hallmark of prostaticadenocarcinoma is the presence ofprominent large nucleoli, as seen

    here. (HPO)-

    Low grade (Gleason score: 1 +1 =2) almost uniform sized malignant glands

    Moderately differentiated Gleason

    score: 3+3 = 6

    Gleason (5+5 =10) poorly

    differentiated/High Grade

    Adenocarcinoma.

    Cryptorchidism

    Testicular atrophy in cryptorchidism.

    The tubules show Sertoli cells but nospermatogenesis. There is thickening

    of basement membranes and an

    apparent increase in interstitial Leydig

    cells

    Embryonal Carcinoma

    Embryonal carcinoma shows sheets of

    undifferentiated cells as well as

    primitive glandular differentiation. The

    nuclei are large and hyperchromatic.

    Yolk Sac Tumor

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    Yolk sac tumor of the testis is shown

    composed of primitive germ cells that

    form glomeruloid or embryonal-like

    structures. These tumors are most

    frequent in children, but overall they

    are rare.

    Schiller-Duval body is a structure seen

    in the endodermal sinus pattern of

    yolk sac tumor.

    Teratoma

    Teratoma of the testis consisting of a

    disorganized collection of glands,

    cartilage, smooth muscle, and

    immature stroma.

    ***End of Transcription***

    Some helpful sites:

    http://library.med.utah.edu/WebPath

    http://webpathology.com


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