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Pathological complete response (pCR) rates after carboplatin-containing neoadjuvant chemotherapy in...

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Pathological complete response (pCR) rates after carboplatin-containing neoadjuvant chemotherapy in patients with germline BRCA (gBRCA) mutation and triple negative breast cancer (TNBC) – <br />Results from GeparSixto<br /><br />Gunter von Minckwitz, Eric Hahnen, Peter A. Fasching, Jan Hauke, Andreas Schneeweiss, Christoph T. Salat, Mahdi Rezai, Jens U. Blohmer, Dirk M. Zahm, Christian Jackisch, Bernd Gerber, Peter Klare, Sherko Kümmel, Holger Eidtmann, Stephan Paepke, Valentina Nekljudova, Sibylle Loibl, Michael Untch, Rita Schmutzler <br />for the <br />GBG/AGO-B study groups<br /> Presented By Gunter Von Minckwitz at 2014 ASCO Annual Meeting
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Page 1: Pathological complete response (pCR) rates after carboplatin-containing neoadjuvant chemotherapy in patients with germline BRCA (gBRCA) mutation and triple.

Pathological complete response (pCR) rates after carboplatin-containing neoadjuvant chemotherapy in patients with germline BRCA (gBRCA) mutation and triple negative breast cancer (TNBC) – <br />Results from GeparSixto<br /><br />Gunter von Minckwitz, Eric Hahnen, Peter A. Fasching, Jan Hauke, Andreas Schneeweiss, Christoph T. Salat, Mahdi Rezai, Jens U.

Blohmer, Dirk M. Zahm, Christian Jackisch, Bernd Gerber, Peter Klare, Sherko Kümmel, Holger Eidtmann, Stephan Paepke, Valentina Nekljudova, Sibylle Loibl, Michael Untch, Rita Schmutzler <br />for the <br />GBG/AGO-B study groups<br />

Presented By Gunter Von Minckwitz at 2014 ASCO Annual Meeting

Page 2: Pathological complete response (pCR) rates after carboplatin-containing neoadjuvant chemotherapy in patients with germline BRCA (gBRCA) mutation and triple.

Introduction

Presented By Gunter Von Minckwitz at 2014 ASCO Annual Meeting

Page 3: Pathological complete response (pCR) rates after carboplatin-containing neoadjuvant chemotherapy in patients with germline BRCA (gBRCA) mutation and triple.

Slide 3

Presented By Gunter Von Minckwitz at 2014 ASCO Annual Meeting

Page 4: Pathological complete response (pCR) rates after carboplatin-containing neoadjuvant chemotherapy in patients with germline BRCA (gBRCA) mutation and triple.

Slide 4

Presented By Gunter Von Minckwitz at 2014 ASCO Annual Meeting

Page 5: Pathological complete response (pCR) rates after carboplatin-containing neoadjuvant chemotherapy in patients with germline BRCA (gBRCA) mutation and triple.

Selected Objectives

Presented By Gunter Von Minckwitz at 2014 ASCO Annual Meeting

Page 6: Pathological complete response (pCR) rates after carboplatin-containing neoadjuvant chemotherapy in patients with germline BRCA (gBRCA) mutation and triple.

Key Eligibility Criteria

Presented By Gunter Von Minckwitz at 2014 ASCO Annual Meeting

Page 7: Pathological complete response (pCR) rates after carboplatin-containing neoadjuvant chemotherapy in patients with germline BRCA (gBRCA) mutation and triple.

pCR Rates (ypT0 ypN0) <br />

Presented By Gunter Von Minckwitz at 2014 ASCO Annual Meeting

Page 8: Pathological complete response (pCR) rates after carboplatin-containing neoadjuvant chemotherapy in patients with germline BRCA (gBRCA) mutation and triple.

Slide 8

Presented By Gunter Von Minckwitz at 2014 ASCO Annual Meeting

Page 9: Pathological complete response (pCR) rates after carboplatin-containing neoadjuvant chemotherapy in patients with germline BRCA (gBRCA) mutation and triple.

Characteristics of patients with TNBC

Presented By Gunter Von Minckwitz at 2014 ASCO Annual Meeting

Page 10: Pathological complete response (pCR) rates after carboplatin-containing neoadjuvant chemotherapy in patients with germline BRCA (gBRCA) mutation and triple.

pCR Rates (%) in Patients with TNBC

Presented By Gunter Von Minckwitz at 2014 ASCO Annual Meeting

Page 11: Pathological complete response (pCR) rates after carboplatin-containing neoadjuvant chemotherapy in patients with germline BRCA (gBRCA) mutation and triple.

Slide 11

Presented By Gunter Von Minckwitz at 2014 ASCO Annual Meeting

Page 12: Pathological complete response (pCR) rates after carboplatin-containing neoadjuvant chemotherapy in patients with germline BRCA (gBRCA) mutation and triple.

pCR (ypT0 ypN0) <br />in all Patients with TNBC

Presented By Gunter Von Minckwitz at 2014 ASCO Annual Meeting

Page 13: Pathological complete response (pCR) rates after carboplatin-containing neoadjuvant chemotherapy in patients with germline BRCA (gBRCA) mutation and triple.

pCR (ypT0/is ypN0) <br />in all Patients with TNBC

Presented By Gunter Von Minckwitz at 2014 ASCO Annual Meeting

Page 14: Pathological complete response (pCR) rates after carboplatin-containing neoadjuvant chemotherapy in patients with germline BRCA (gBRCA) mutation and triple.

Prediction of Carboplatin Effect on pCR

Presented By Gunter Von Minckwitz at 2014 ASCO Annual Meeting

Page 15: Pathological complete response (pCR) rates after carboplatin-containing neoadjuvant chemotherapy in patients with germline BRCA (gBRCA) mutation and triple.

Summary

Presented By Gunter Von Minckwitz at 2014 ASCO Annual Meeting

Page 16: Pathological complete response (pCR) rates after carboplatin-containing neoadjuvant chemotherapy in patients with germline BRCA (gBRCA) mutation and triple.

Conclusion

Presented By Gunter Von Minckwitz at 2014 ASCO Annual Meeting

Page 17: Pathological complete response (pCR) rates after carboplatin-containing neoadjuvant chemotherapy in patients with germline BRCA (gBRCA) mutation and triple.

Acknowledgements

Presented By Gunter Von Minckwitz at 2014 ASCO Annual Meeting


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