IDEAL

PATHOPHYSIOL

OGY:

pathogenesis

metastasis

angiogenesisACTUAL CONCEPT MAP

PATIENT TC:

hemothorax

ascites

profound anorexia

PREDISPOSING FACTORS

Hello there!

PRECIPITATING FACTORS

Biologic agents?

Physical agents?

Chemical agents?

Diet?

“Central Dogma of Molecular Biology”

Hello! These are

some kinds of

mutations.

Ovarian proto-oncogenes:

ras

akt-2

Ovarian tumor

suppressor genes:

BRCA2

BRCA1

Mechanisms of Metastasis

peritoneal seeding lymphatic spread hematogenous spread

Angiogenesis

Where did the ASCITES come from?

• Vascular permeability

factor

• ↑ permeability

• Fluids leak into peritoneal

cavity

• Diaphragm lymphatics obstructed

• ↓ drainage of fluid from

peritoneal cavity

ASCITES

Where did the HEMOTHORAX come from?

• blood vessels destroyed

• cancer cells and WBC in

pleural cavity

• pleural cavity cells pull

in more fluids

HEMOTHORAX

Where did the ANOREXIA come from?

• immune cellscytokines

• cytokineshypothalamus

anorexia

• anorexialow food & fluid intake

Anorexia &

Muscle Wasting

The end! Thanks for listening!