Patient Survey Data Results: Reminder Preferences in Patient-Reported Outcomes Studies
Mark WadeDirector, Patient Focused SolutionsAlmac
@AlmacClinTech
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Objectives
Identify the most common reasons why patients can be non-compliant with their patient diaries
Identify reminder modes patients prefer and evaluate reminder strategies preferences and mode feasibility
Plan future implementation of reminders on PROs based on patient preferences and the feasibility of reminder modes
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Keeping Patients Engaged
PROs keep patients
engaged by directly
involving them in patient-centered research
Reminders can be a beneficial
feature of eCOAs which
can keep patients
engaged, while also promoting
optimal compliance
Important to plan an
effective reminder
strategy that would work
best for engaging the patient during
the trial
To identify effective reminder strategies, survey data that focused on patient preferences for reminders in PROs was investigated
• Global sample; N=405 • Included patients who participated in
at least 1 clinical trial with patient diaries in the past 2 years
• Internet-based survey; ~20-30 minutes• Previous diary experiences, preferences, future
suggestions, personal technology behaviors
Patient Preferences in Completing Patient Diaries
To better understand patient preferences when participating in PROs, Almac conducted survey research in 2013
Survey Demographics
48.0%52.0%
Gender
Male
Female
12.6%
64.0%
23.4%
Region
Europe
N. America
Rest of World
N=405
N=405
N=404
32.1%
29.6%
21.2%
17.0%
Age
18-29
30-39
40-49
50+
Patient Compliance Based on Most Recent Clinical Trial
Diary-Use in Most Recent Clinical TrialPatient Compliance with Completing Diaries
• Subjects were asked to report if they were always compliant with patient diaries in their most recent clinical trial
• Compliance is often inflated when self-reported by patients• Compliance is quite low as self-reported by patients, and if
this is inflated, compliance may need some enhancement in clinical trials
46.4%53.6% Non-compliant
Compliant
N=398
Diary-Use in Most Recent Clinical TrialNon-compliance: Demographic
Characteristics
0%
20%
40%
60%
80%
100%
18-29 30-39 40-49 50+
Age
Non-compliant
Compliant
N=398
(p=.07)
0%
20%
40%
60%
80%
100%
PositiveSatisfaction
Dissatisfaction
Patient Satisfaction
Non-compliant
Compliant
N=398
(p=0.001)
Diary-Use in Most Recent Clinical TrialNon-compliance:
Overall satisfaction with diary experience
Diary-Use in Most Recent Clinical TrialNon-compliance: Negative experience factor =
hard to remember
0%
15%
30%
45%
60%
75%
Did Not Select Selected NegativeFactor
Non-compliantCompliant
N=398
(p<.01)(n=317) (n=81)
Diary-Use in Most Recent Clinical TrialReasons for Non-compliance of
Non-compliant Respondents
0%
15%
30%
45%
60%
They Forgot Too Busy DiaryAccess
Other
N=185
Planning for Future PRO TrialsBased on Patient Recommendations
Future Clinical Trials:Helpfulness Ratings of Reminders
for Patient Diaries
0%
15%
30%
45%
60%
75%
90%
High AttractivenessRating (5-7)
Low/OK AttractivenessRating (1-4)
77.2%
22.8%
N=403
0%
15%
30%
45%
60%
75%
90%
Female Male
83.9%71.4%
16.2%28.6%
Gender
High AttractivenessRating (5-7)
Ok/Low AttractivenessRating (1-4)
Future Clinical Trials:Helpfulness Ratings of Reminders
for Patient Diaries
N=403
(p<.01)
Future Clinical Trials:Helpfulness Ratings of Reminders
for Patient Diaries
0%
15%
30%
45%
60%
75%
90%
Did Not Select Selected NegativeFactor
79.0%
56.4%
21.0%
43.6%
Reminders were annoying
High AttractivenessRating (5-7)
Ok/Low AttractivenessRating (1-4)
N=398
(p<.01)
Future Clinical Trials:Preferred Reminders Modes
0%
15%
30%
45%
60%
75% 67.2%
34.3% 32.6%
18.0% 16.1%6.2% 5.7%
0.5%
N=403
Future Clinical Trials:When Patients Want To Be Reminded
to Complete Diary Entries
0%
15%
30%
45%
2.8%
39.2%
25.3%32.3%
0.5%
N=403
Future Clinical Trials:When Patients Want To Be Reminded
to take study meds
0%
15%
30%
45%
5.0%
33.8%
20.6%
5.7%
16.6%
2.5%
15.9%
N=403
Future Clinical Trials:When Patients Want To Be Reminded
of study visits
0%
15%
30%
45%
NOReminder
On day ofappt
1 dayBEFORE
2 daysBEFORE
5.0%
33.8%
20.6%
5.7%
N=403
Future Clinical Trials:When Patients Want To Be Reminded
to collect study samples
0%
15%
30%
45%
60%
NO Reminder 1 day BEFORE 1x on the day 2x on the day
5.5%
53.9%
28.8%
11.9%
N=403
Future Clinical Trials:Patient Suggested Improvements to Enhance
ePRO Experience
0%
15%
30%
45% 34.1%
28.4%27.7%
21.5% 19.8%14.6% 13.3% 12.1%
N=403
Patient Technology Behaviors
Patient Technology Behaviors:Types of Technologies/
Devices Owned by Subjects
0%
15%
30%
45%
60%
75%
90%
Computer SmartPhone
Landline Cell Phonew/
UnlimitedTexting
Tablet Cell Phonew/o
UnlimitedTexting
None
81.2%
60.5%
49.9% 49.4%37.0%
16.8%
1.0%
N=403
Patient Technology Behaviors:Hours Per Day Spent Using a Computer
0%
15%
30%
45%
<=2 hrs 3-5 hrs 6-8 hrs 9-12 hrs >=13 hrs
24.7%
42.0%
16.3%
9.1% 8.0%
N=403
Patient Technology Behaviors:Checking Text Messages vs.
Emails Upon Receipt
0%
15%
30%
45%
60%
Text Messages Emails
52.9%
15.1%
N=403
(p<.0001)
Conclusions
Planning Reminder Strategies Well
With today’s technologies, study design must keep pace with patients’ behaviors and preferences when developing effective
reminder strategies
Results suggest incorporating optimal reminder strategies can positively affect patient experience and compliance
Results show that patients prefer to be reminded
Top non-compliance reason is “forgetting” suggesting that reminders can be helpful in enhancing compliance
Patient preferences for reminders related to diaries and other study tasks should be given careful consideration
Thank you
Mark WadeDirector, Patient Focused SolutionsAlmac@AlmacClinTech
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