National Office • 1821 University Ave W, Ste S256 • St. Paul, MN 55104-2897 • Phone: (800) 541-5454 • (651) 917-6256 Fax: (651) 917-1835 • E-mail: [email protected]• Web site: www.myasthenia.org Myasthenia Gravis Foundation M/SAB AGENDA October 6, 2007 Room: Hoover Marriott Wardman Park Hotel, Washington, DC 7:30 – 8:30 am (Executive Committee) 11:30 am – 1:00 pm (full board) Call to Order Pascuzzi Introductions/Attendance Pascuzzi Adjustment to Agenda Pascuzzi New/Current Officers Pascuzzi Approval of April 30, 2007 meeting minutes Pascuzzi New members Ted Michael Burns, MD Jonathan Katz, MD Lorne Zinman, MD MGFA Award in honor of John Newsom-Davis Pascuzzi State of the Foundation/Research Agenda Schulhof Research Update Committee Reports Scientific Program Committee Wolfe Professional & Public Information Committee Pascuzzi Research & Grants Committee Meriggioli Viets Fellowship Committee Penn Information Technology Committee Ruff Clinical Research Standards Committee Wolfe Old Business MGFA M/SAB members Review membership roster Barohn ew members
Transcript
National Office • 1821 University Ave W, Ste S256 • St. Paul, MN 55104-2897 • Phone: (800) 541-5454 • (651) 917-6256
Marriott Wardman Park Hotel, Washington, DC 7:30 – 8:30 am (Executive Committee)
11:30 am – 1:00 pm (full board)
Call to Order Pascuzzi Introductions/Attendance Pascuzzi
Adjustment to Agenda Pascuzzi New/Current Officers Pascuzzi Approval of April 30, 2007 meeting minutes Pascuzzi New members
Ted Michael Burns, MD Jonathan Katz, MD Lorne Zinman, MD
MGFA Award in honor of John Newsom-Davis Pascuzzi State of the Foundation/Research Agenda Schulhof
Research Update
Committee Reports
Scientific Program Committee Wolfe Professional & Public Information Committee Pascuzzi Research & Grants Committee Meriggioli Viets Fellowship Committee Penn Information Technology Committee Ruff Clinical Research Standards Committee Wolfe
Old Business MGFA M/SAB members Review membership roster Barohn
ew members
Myasthenia Gravis Foundation M/SAB
Minutes April 30, 2007 Boston Mass
11:30 am – 1:00 pm
Call to Order Introductions/Attendance (Pascuzzi, Barohn, Drachman, Kaminski, Richman, Weiss, Kissel, Sanders, Massey, Daroff, Pourmand, Weinberg, Goldstein, Ruff, Mozaffar) Approval of October 7, 2006 meeting minutes: approved Pascuzzi State of the Foundation Pascuzzi 1) Current MGFA Board leadership headed by new Chair Sam Schuhof (Esther Land has
completed her tenure as Chair). The lay board has significant new membership and strong leadership and the dynamics of the board appear to be favorable.
2) Administration (Jan Golden, Mat Spaan, and staff) provide a solid administrative infrastructure for accomplishing the goals of the MGFA
3) Chapter membership appears stable at this juncture. 4) Recent annual MGFA meeting in Washington well attended and given superb reviews by
attendees. 5) Financial status of the MGFA has taken an important new direction. Main new development is
the successful acquisition of large gifts. Names and locations of the 5 major gifts in the past year were announced. Cummings Research Endowment – California; William Vargas – Ohio; Doreen Kearschner – Cleveland, Ohio; Florence Munro – Toronto, Canada; Kenneth Hess – Lansing, Michigan. Most significant is the Cummings gift of approximately $4 million (gifted to serve as a basis endowment the interest of which is to fund research over the long-term).
6) MGFA leadership is supportive of funding proposals as recommended by the MSAB. 7) At the request of the MSAB the MGFA board approved the establishment of $50K and call for
proposals to fund a planning grant for clinical trial(s) of mycophenolate.
Research Update Pascuzzi/Barohn
MGFA will fund 3 new Osserman fellowship this year as well as another second-year fellowship (4 stipends in total) as well as three Viets. Implications of the Cummings gift and the intent to grow the endowment were discussed. MGFA leadership is supportive of funding proposals as recommended by the MSAB and requesting a list of research goals and projects for targeted fundraising. CellCept Study Group activities summarized. This committee (Sanders, Meriggioli, Barohn, Massey, Pascuzzi, Howard, Siddiqi) has explored the implications and meaning of the 2 recently completed controlled trials of mycophenolate in MG. The group has explored new/different models for a clinical trial in order to clarify the role of this drug in the treatment of MG. Several potential models have been drafted and discussed. The committee believes that it is important to design a new trial for mycophenolate in MG. At the request of the MSAB the MGFA board approved the establishment of $50K and call for proposals to fund a planning
National Office • 1821 University Ave W, Ste S256 • St. Paul, MN 55104-2897 • Phone: (800) 541-5454 • (651) 917-6256
grant for clinical trial(s) of mycophenolate. Rick Barohn emphasized the importance of maintaining a commitment to basic research but also developing a more robust emphasis on support for clinical research by the MGFA. While the MGFA will not have sufficient resources to fund clinical trials it should have (with its new and growing research endowment) sufficient resources to fund planning grants and pilot proposals in the clinical arena. Some modification of the research committee structure and function is likely in order to optimally manage the basic and also the clinical research activities.
Committee Reports Scientific Program Committee: Dr Merrigioli and Dr Wolfe will coordinate planning for the October 2007 Scientific session in Washington DC in conjunction with the ANA meeting. 11th International Meeting update: Kaminski/Barohn Outstanding 3-day program in place for May 14-16 Chicago with advance registration exceeding expectations. The MSAB salutes the extensive efforts and skills of Drs Barohn and Kaminski for creating and realizing such a magnificent program.
Professional & Public Information Committee Pascuzzi Updated version of Medications and Myasthenia Gravis (A Reference for Health Care Professionals) completed and posted on the MGFA website January 2007. CellCept statements (based on results of the two controlled trials) prepared and posted on website and in MGFA newsletter. Subcommittee assigned to review, update, correct old and new website literature and documents includes Dr. Pourmand, Dr. Engstrom, and Dr. Arnaudo. Dr. Chip Howard has submitted the major work entitled Myasthenia Gravis: A Manuel for the Health Care Provider (Professional Manual). It is going through review prior to posting and dissemination. Research & Grants Committee Drachman Nine solid proposals for the Osserman fellowships. Three recommended for funding. One project from last year recommended for funding for a second year (Dr. Wu). See Dr. Drachman’s written report for details.
Viets Fellowship Committee Pascuzzi for Penn Two applications thus far for 2007. Both will likely be funded. Clinical Research Standards Committee Phillips No report at this time. MSAB EC considering a modification of this committee and its charge.
Nomination committee. Convened December 2006 in Durham and recommended slate for new officers beginning October 2007 is as follows. Chair: Dr. Richard Barohn Vice-Chair: Dr. Henry Kaminski Secretary: Dr. Gil Wolfe Assistant Secretary: Dr. Matthew Merrigioli Immediate Past Chair: Dr. Robert Pascuzzi
MGFA M/SAB membership Review of membership roster in progress Barohn
New member nomination: Bashar Katirji, M.D., F.A.C.P. from Case Western reserve. Proposed by Dr. Daroff. Second by Dr. Kaminski. CV reviewed and discussed. MSAB by unanimous vote elects Dr. Katiriji to the MSAB.
New Business
Centers of Excellence (committee to explore the establishment of COE for MG program) Research 5-10 year strategic plan (committee to develop an outline of appropriate goals/targets for basic and clinical research, prioritization, and estimation of necessary resources. CellCept Proposal Funding (see above) Rahman Pourmand was named “Doctor of the Year” by the MGFA at its annual meeting earlier this month in Washington DC. The entire MSAB salutes Dr. Pourmand.
Next Meeting October 6, 2007
Marriott Wardman Park, Hotel, Washington DC Adjournment Minutes respectfully submitted by Robert Pascuzzi Adjournment
CURRICULUM VITAE
Ted Michael Burns, M.D. Personal Data: Date of birth: September 2, 1966 Married, 3 children Current address: 1943 Lewis Mountain Road Charlottesville, VA 22903 434-296-1136
University of Virginia Department of Neurology PO Box 800394 Charlottesville, VA 22908 (434) 982-0170
Education: Undergraduate: 5/89 B.A. University of Kansas, Lawrence KS, Biological Sciences Medical School: 5/94 M.D. University of Kansas, School of Medicine
Post Graduate Training:
06/94 – 07/95 Internship, Medicine, University of Kansas Medical Center 07/95 – 07/98 Residency, Neurology, University of Virginia 07/98 – 07/99 Fellowship, Neuromuscular Disease and Electromyography, University of
Virginia 07/99 – 09/00 Fellowship, Peripheral Nerve Disease, Mayo Clinic, Rochester, Minnesota
Academic Appointments: 7/06 – present Associate Professor, University of Virginia, Dept of Neurology 11/02 – 6/06 Assistant Professor, University of Virginia, Dept of Neurology 07/04 – present Residency Program Director, University of Virginia, Dept of Neurology 11/02 – 6/04 Associate Residency Program Director, Dept of Neurology 12/02 – present Member, University of Virginia Graduate Medical Education Committee Other Employment Pertaining to Current Professional Appointments: 07/05 – present Director, Electromyography Laboratory, University of Virginia Previous Employment 09/00 – 11/02 Senior Staff Neurologist, Lahey Clinic, Burlington, MA 12/00 – 11/02 Director, Autonomic Laboratory, Lahey Clinic 05/01 – 11/02 Consulting Staff, Children’s Hospital, Boston MA Certification and Licensure: 1994 Diplomate – National Board of Medical Examiners 1996 Licensed by the Virginia Board of Medicine to practice Medicine & Surgery.
1999 Diplomate of Neurology American Board of Psychiatry and Neurology 2002 Added Qualifications in Clinical Neurophysiology, American Board of Psychiatry
and Neurology 2003 Neuromuscular Pathology in Nerve Pathology, AAN committee on
Neuromuscular Pathology 2007 American Board of Electrodiagnostic Medicine (ABEM)
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Honors and Awards: 2006 Master Educator Award, University of Virginia School of Medicine. Awarded
annually by the University of Virginia Graduate Medical Education to two faculty of the School of Medicine.
2005 Dean’s Teaching Award of Excellence, University of Virginia School of
Medicine. Awarded annually to 6 – 7 faculty of the School of Medicine. 2005 Elected Member, Academy of Distinguished Educators, University of Virginia
School of Medicine 2005 Invited to participate in the 2006 Leadership in Academic Medicine sponsored by
the University of Virginia School of Medicine 2005 Selected, Best Doctors in America 2004 Excellence in Teaching Award, Department of Neurology, University of Virginia,
annual award presented by the neurology residents
1997 James Q. Miller Teaching Award, Department of Neurology, University of Virginia, for teaching excellence
1993 Alpha Omega Alpha, Kansas Alpha Chapter. Professional Affiliations 1994 – present American Academy of Neurology 2002 – present American Academy of Neuromuscular and Electrodiagnostic Medicine 2002 – present Virginia Neurological Society 2003 – present American Board of Psychiatry and Neurology, Clinical Neurophysiology
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Lectures and Symposiums (outside UVA) 04/30/07 Boston, MA. American Academy of Neurology annual meeting.
“Guillain-Barre Syndrome”. 12/12/06 Washington, DC. NINDS Enhancing Clinical Research Awareness in
Residency Training Workshop. “Incentives for Clinical Research Initiative”.
09/21/06 Indianapolis, Indiana. Indiana University. “An approach to the evaulation
of neuropathy.” Neurology Resident and Fellow conference. 09/21/06 Indianapolis, Indiana. Indiana University. Neurology Grand Rounds,
Clinicopathological Conference: An HIV (+) patient with gradually progressive weakness.
09/13/06 Durham, North Carolina. Duke University. “An approach to the evaluation
of neuropathy.” Neuromuscular Conference. 05/04/06 Rochester, Minnesota. Mayo Clinic, Neuromuscular Disease Symposium
in honor of Dr. Peter J. Dyck and Dr. Andrew G. Engel. Lecturer: “The Natural History and Outcome of 57 Cases of Limb Sarcoidosis Neuropathy.”
09/21/05 Monterey, California. American Academy of Neuromuscular and
Electrodiagnostic Medicine (AANEM, formerly AAEM) annual scientific meeting. Case presentation: “Patient with Novel Myelin Protein Zero Mutation causing Unusual Clinical Presentation”. Challenging Neuromuscular and Electrodiagnostic Cases Dinner Seminar.
07/26/05 Harrisonburg, Virginia. An introduction to the evaluation and management
of polyneuropathies and mononeuropathies, Rockingham Memorial Hospital, Continuing Medical Education Program,
04/05 Miami, Florida. American Academy of Neurology annual meeting; co-chair of Scientific Session S42, EMG and Neuromuscular Disorders.
11/04 Savannah, Georgia. American Academy of Electrodiagnostic Medicine
annual scientific meeting. Lecturer: “Clinical Aspects of Autonomic Neuropathies”. Diagnosis and Treatment of Autonomic Neuropathy Symposium.
3/21/03 Wintergreen, Virginia. Neurology Residency Program annual educational
retreat. Invited speaker: “Life after Residency”.
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National and State Committees & Councils 08/06 – present Member, Steering Committee, NINDS Enhancing Clinical Research
Awareness in Residency Training Workshop 07/06 – present Member, Medical Advisory Board and Board of Trustees, Myasthenia
Gravis Foundation, Virginia & West Virginia Chapter 06/06 – present Chair, AANEM Podcast Editorial Board 06/06 – present Member, AANEM Website CME committee 2005 – present Member, Muscle Study Group 2003 – present Member, Neurophysiology Section of American Academy of Neurology 05/03 – 06/06 American Academy of Neuromuscular and Electrodiagnostic Medicine
(AANEM), Workshop Committee 02/04 – present American Board of Psychiatry and Neurology, Clinical Neurophysiology
Committee 08/03 – present American Board of Psychiatry and Neurology, Neurology Recertification
Committee School, University, UVA Hospitals, Departments Committees & Councils 01/07 – present Member, UVA Education subcommittee for Graduate Medical Education 09/06 – present Member, Appreciative Inquiry Leadership Team, University of Virginia
School of Medicine 09/05 – present Member, LCME subcommittee for Evaluation of Program Effectiveness,
Educational Program for the MD Degree 08/04 – present Member, Education Curriculum Advisory Committee for Neurology
Clerkship 07/04 – present Chair, Education Curriculum Committee for Neurology Program 07/04 – present Member, University of Virginia, Graduate Medical Education Committee
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Other Teaching and Professional Activities 09/21/06 Visiting Professor, Indiana University Neurology Department 0/6/06 – present Editor-in-chief, “AANEM presents Nerve and Muscle Junction” Podcast 07/05 – present Program Director, Neurology Residency Program 01/03 – 06/05 Associate Program Director, Neurology Program Papers Published or in Press Peer-reviewed publications: (asterick indicates that Dr. Burns is corresponding author; underlined name indicates trainee under Dr. Burns’s supervision) 1. Burns TM, Clough JA, Klein RM, Wood GW, Berman NEJ. Developmental regulation of
cytokine expression in the mouse brain. Growth Factors 1993;9:253-258. 2. Burns TM, Juel VJ, Sanders DB, Phillips LP. Neuroendocrine lung tumors and disorders of
the neuromuscular junction. Neurology 1999;52:1490-1491. 3. Burns TM, Juel VJ, Hess CE, Phillips LH. Motor neuron disease and serum monoclonal
proteins: poor response to treatment of the paraproteinemia. J Clin Neuromusc Dis 2000;2:70-72.
4. Burns TM, Lawn NC, Low PA, Camilleri M, Wijdicks EFM. Adynamic ileus in severe
positive sensory symptoms as endpoints in diabetic neuropathy trials. J Neurol Sci 2001;189:3-5.
7. Burns TM, Taly A, O’Brien PC. Dyck PJ. Clinical versus quantitative vibration assessment:
improving clinical performance. J Periph Nerv System 2002;7:112-117.
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8. Klein CJ, Dyck PJB, Friedenberg SM, Burns TM, Windebank AJ, Dyck PJ. Inflammation and neuropathic attacks in hereditary brachial plexus neuropathy. J Neurol Neurosurg Psych 2002;73:45-51.
9. Burns TM, Russell JA, LaChance DH, Jones HR. Oculobulbar involvement is typical with
Lambert-Eaton myasthenic syndrome. Annals Neurol 2003;53:270-273. 10. Burns TM, Ryan M, Darras BT, Jones HR. Current therapeutic strategies for patients with
polyneuropathy secondary to inherited metabolic disorders. Mayo Clinic Proceedings 2003;78:858-868.
11. Burns TM. Neurosarcoidosis. Arch Neurol 2003;60:1166-1168. 12. Burns TM, Jones HR, Phillips LH, Bugawan TL, Erlich HA, Lennon VA. Clinically
Disparate Stiff-person syndrome with GAD65 Autoantibodies in a Father and Daughter. Neurology 2003;61:1291-1293.
13. Cameron CL, Kang PB, Burns TM, Darras BT, Jones HR. Multifocal Slowing of Nerve
following successful bariatric surgery. Case report and review of the literature. J Neurosurg 2006:105;631-635.
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22. McFarland NR, Login IS, Vernon S, Burns TM*. Clinical improvement following corticosteroids and azathioprine in GAD65-associated cerebellar ataxia. Neurology 2006;67:1308-1309.
23. Burns JM, Mauermann ML, Burns TM*. An easy approach to the evaluation of neuropathy.
J Family Practice; 2006;55:853-861. 24. Dimberg EL, Crowe SE, Trugman JM, Swerdlow RH, Lopes MBS, Bourne D, Burns TM*.
Fatal encephalitis in a patient with refractory celiac disease presenting with myorhythmia and carpal spasm. Movement Disorders 2007;22:407-411.
25. Burns TM*. The forecast for podcasts: Sunny skies but not necessarily with clear visibility.
Neurology 2007;68:E19-20. Invited Reviews or Editorials: 1. Burns TM. Vasculitic Neuropathy. Continuum. Lifelong Learning in Neurology.
2003;9:146-159.
2. Burns TM. A Step Forward for Stiff Persons. Lancet 2005;365:1365-1367. 3. Dimberg E, Burns TM*. Management of common neurologic conditions in sports. Clinics in
4 Burns TM, Phillips LH, Jones HR. Stiff person syndrome does not always occur with maternal passive transfer of GAD65 antibodies (letter). Neurology 2005;64:399-400.
Book Reviews: 1 Burns TM. Book review of “Atlas of Neuromuscular Diseases: A Practical Guideline”.
Journal of Neuro-ophthalmology 2007; in press. Editorial Responsibilities: Guest Editor, “Neuromuscular Disorders: Evaluation and Management” issue of Seminars in
Neurology, 2007, in progress. Member, Editorial Board, The Journal of Neurodegeneration and Regeneration. Prime National Publishing, Boston, MA. Consultant, “Body: The Complete Human”, National Geographic, 2007; in progress. Associate Editor, Netter’s Neurology. 1st edition. Icon Learning Systems, 2005. Section Editor: Plexopathies, Neuromuscular Transmission Disorders Ad hoc reviewer: Muscle & Nerve, Clinical Neuropharmacology, Neurology, Lancet, Lancet Neurology, Critical Car, Archives of Neurology, Nature Clinical Practice Neurology, Neuropathology and Applied Neurobiology
Chapters: 1. Burns TM, Dyck PJB. Treatment of Vasculitic Neuropathy, in Johnson RT, Griffin JW
(eds): Current Therapy in Neurologic Diseases. 6th edition. Mosby-Year Book, Inc, 2001. p. 390-394.
Demyelinating Polyradiculoneuropathy, in Jones HR, Darras B, DeVivo DC (eds): Neuromuscular Disorders of Infancy, Childhood and Adolescence. Butterworth-Heinemann, 2002. p. 445-468.
2. Burns TM. Inherited Neuropathies with Known Metabolic Derangement, in Noseworthy JH
(ed): Neurological Therapeutics: Principles and Practice, Martin Dunitz, 2003. p. 2166 – 2180.
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3. Burns TM, Darras B, Jones HR. Pediatric Peripheral Neuropathy, in Dyck PJ, Thomas PK (eds): Peripheral Neuropathy. 4th edition. Saunders, 2005. in press.
4. Burns TM. Mechanisms of Acute and Chronic Compression Neuropathy, in Dyck PJ,
Thomas PK (eds): Peripheral Neuropathy. 4th edition. Saunders, 2005. in press. 5. Burns TM, Russell JM. Overview of Peripheral Nerve Disease, in Jones HR (ed): Netter’s
Neurology. 1st edition. Icon Learning Systems, 2005. 6. Burns TM, Jones HR. Brachial Plexus and Brachial Plexopathies, in Jones HR (ed): Netter’s
and Chronic Inflammatory Demyelinating Polyradiculoneuropathy, in Jones HR (ed): Netter’s Neurology. 1st edition. Icon Learning Systems, 2005.
8. Burns TM, Jones HR. Lambert-Eaton Myasthenic Syndrome, in Jones HR (ed): Netter’s
Neurology. 1st edition. Icon Learning Systems, 2005. 9. Burns TM, Ryan MJ, Jones HR. Myasthenia Gravis, in Jones HR (ed): Netter’s Neurology.
1st edition. Icon Learning Systems, 2005. 10. Burns TM, Ryan MJ. Lumbosacral Plexopathies, in Jones HR (ed): Netter’s Neurology. 1st
edition. Icon Learning Systems, 2005. 11. Ryan MJ, Burns TM, Russell JA, Jones HR. Multifocal Neuropathies, in Jones HR (ed):
Netter’s Neurology. 1st edition. Icon Learning Systems, 2005. 12. Burns TM, Srinivasin J, Russell JA. Disorders of the Autonomic Nervous System, in Jones
HR (ed): Netter’s Neurology. 1st edition. Icon Learning Systems, 2005. 13. Burns TM, Jones HR. Stiff-person syndrome, in Jones HR (ed): Netter’s Neurology. 1st
edition. Icon Learning Systems, 2005. 14. Burns TM, Bradshaw D, Kuntz N. Clinical Neurophysiology of Pediatric Polyneuropathies.
In Holmes G, Moshe, Jones HR: Clinical Neurophysiology of Infants, Children and Adolescents. Butterworth-Heinemann, 2005, pp 645 - 686.
15. Ryan M, Burns TM, Kuntz N. Autonomic Testing in Childhood. In Holmes G, Moshe, Jones
HR: Clinical Neurophysiology of Infants, Children and Adolescents, Butterworth-Heinemann, 2005, pp. 687 - 712.
16. Dimberg E, Burns TM. Inherited Neuropathies with Known Metabolic Derangement, in
Noseworthy JH (ed): Neurological Therapeutics: Principles and Practice. 2nd edition. Martin Dunitz, 2005, in press.
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17. Lockman J, Burns TM. Stiff-person Syndrome, in Johnson RT, Griffin JW (eds): Current Therapy in Neurologic Diseases. 9th edition; 2007; in press.
Abstracts: 1. Burns TM, Clough JA, De M, Berman NEJ, Klein RM, Wood GM. Cytokine gene
expression in the developing brain. Neuroscience Abstracts 1991;17:45. 2. Klein RM, Burns TM, Clough JA, Wood GW, De M, Berman NEJ. Differential expression
of cytokines during mouse brain development. J Neuroimmunol Supplement 1991;1:62.
3. Burns TM, Clough J, Berman NEJ, Wood GW, Klein RM. Expression of transforming growth factor-beta (TGF-B) in the developing and adult brain of the mouse. Anat Rec 1992; 232:51A.
4. Clough JA, Burns TM, De S, Wood GW, Berman NEJ, Choudhuri R, Klein R. Expression
of cytokine gene products in the mouse brain during development. Molecular Biol Cell 1992;3:A357.
5. Burns TM, Lawn NC, Low PA, Camilleri M, Wijdicks EFM. Adynamic ileus in severe
Guillain-Barre syndrome. Neurology 2000;54:A162 6. Kraljevic TK, Burns TM, Juel VC. Pregnancy and exacerbation of peripheral neuropathy in
Charcot-Marie-Tooth disease. American Academy Electrodiagnostic Medicine, 2000, Philadelphia, PA.
7. Burns TM, Taly A, O’Brien PC, Dyck PJ. Clinical versus the quantitative vibration
assessment: Pitch the tuning fork or improve the physician’s performance. Neurology 2001:3:Suppl: 207A. abstract.
8. Burns TM, Taly A, O’Brien PC, Dyck PJ. Clinical versus the quantitative vibration
assessment: Pitch the tuning fork or improve the physician’s performance. Peripheral Nerve Society, 2001, Tyrol, Austria.
9. Quijano-Roy S, Burns TM, Jones HR, Darras BT. Childhood CIDP: The Children’s Hospital
of Boston experience. Peripheral Nerve Society, 2001, Tyrol, Austria. 10. Klein CJ, Burns TM, Dyck PJB, Friedenberg SM, Dyck PJ. Mechanistic insights and biopsy
evidence for an immune-inflammatory component in hereditary brachial neuropathy. J Peripheral Nerve Society 2001;6:153, Tyrol, Austria.
11. Quijano-Roy S, Burns TM, Jones HR. Successful intravenous immunoglobulin treatment of
severe sensorimotor polyneuropathy associated with Sjogren’s syndrome. Boston Society of Neurology and Psychiatry, 2001, Boston, MA.
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12. Burns TM, Jones HR, Phillips LH, Lennon VL. Familial Stiff-Man Syndrome (SMS) with GAD65 antibody. Annals Neurol 2001;50:S52.
13. Burns TM, Dyck PJB, Auger RG, Aksamit A, Dyck PJ. Clinical features and natural history
of limb sarcoid neuropathy. Neurol 2002;58:A68. 14. Quijano-Roy S, Burns TM, Jones HR. Successful intravenous immunoglobulin treatment of
severe sensorimotor polyneuropathy associated with Sjogren’s syndrome. 7th International Congress of the World Muscle Society, October 2002. Rotterdam, The Netherlands.
15. Burns TM, Dyck PJB, Aksamit A, Dyck PJ. The diagnostically informative clinical features
of limb sarcoid neuropathy: A review of 57 cases. J Peripheral Nervous System 2005;10:S13. 16. Dyck PJB, O’Brien PC, Bosch EP, Grant I, Burns TM, Windebank AJ, Haubenschild,
Peterson D, Norell J, Capelle SK, Lodermeier KA, Dyck PJ. Results of a controlled trial of IV methylprednisolone in diabetic lumbosacral radiculoplexus neuropathy (DLRPN): A preliminary indication of efficacy. J Peripheral Nervous System 2005;10:S21.
and outcome of 57 cases. Mayo Clinic Neuromuscular Disease Symposium in honor of Dr. Peter J. Dyck and Dr. Andrew G. Engel. May 2006.
18. Dyck PJB, O’Brien PC, Bosch EP, Grant I, Burns TM, Windebank AJ, Klein CJ,
Haubenschild, Peterson D, Norell J, Capelle SK, Lodermeier KA, Dyck PJ. The multi-center double-blind controlled trial of IV methylprednisolone in diabetic lumbosacral radiculoplexus neuropathy. Mayo Clinic Neuromuscular Disease Symposium in honor of Dr. Peter J. Dyck and Dr. Andrew G. Engel. May 2006.
19. Pasnoor M., Wolfe G., Nations S., Trivedi J., Barohn R., Herbelin L., McVey A., Kissel J.,
Walsh R., Amato A., Mozaffar T., Hungs M., Chui L., Goldstein J., Novella S., Burns TM., Phillips L., Claussen G., Oh S. Clinical findings in MuSK-antibody positive myasthenia gravis. Presented at the 59th annual meeting of the American Academy of Neurology, May 2007, Boston, MA.
20. Burns TM, Conaway M, Sanders DB and The Muscle Study Group. Effect of quality-of-life
on from impairment of various regional domains affect in myasthenia gravis: MSG Cellcept trial experience. The 11th International Conference on Myasthenia Gravis and Related Disorders. May 2007, Chicago, Il.
21. Pasnoor M., Wolfe G., Nations S., Trivedi J.,Young A, Barohn R., Herbelin L., McVey A.,
Kissel J., Walsh R., Amato A., Mozaffar T., Hungs M., Chui L., Goldstein J., Novella S., Burns TM., Phillips L., Claussen G., Bertorini T, Oh S. Clinical findings in MuSK-antibody positive myasthenia gravis. The 11th International Conference on Myasthenia Gravis and Related Disorders. May 2007, Chicago, Il.
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Myasthenia Gravis Foundation M/SAB
Nomination for Membership to the MGFA MSAB, Jonathan Katz, MD I wish to second the nomination of Jonathan Katz, MD to be elected to the MGFA MSAB. Dr. Barohn is submitting the primary nomination. Dr. Katz is well-known as a neuromuscular authority and is active within the neuromuscular section of the AAN. He is among the foremost thought-leaders on the use of IVIg in neuromuscular diseases including MG and has taken a central role in working with various health care agencies and organizations in an effort to optimize patient care issues (including access) with regard to IVIg. His impact on the MGFA will be immediate in that the IVIg situation is increasingly complex problematic for many patients and treating physicians. Sincerely Robert M Pascuzzi MD
Chair of the MGFA MSAB Department of Neurology Emerson Hall 125 545 Barnhill Drive Indiana University School of Medicine Indianapolis, IN 46202 USA Telephone: 317/274-4455 E-mail: [email protected]
National Office • 1821 University Ave W, Ste S256 • St. Paul, MN 55104-2897 • Phone: (800) 541-5454 • (651) 917-6256
California Pacific Medical Center 2324 Sacramento Street, Suite 111
San Francisco, CA 94115
Curriculum Vitae PERSONAL: Born: May 14, 1962, Mount Vernon, NY Married: Lucy Parke George Children: Sarah, born January 25, 1995 Hannah, born August 28, 1999 Home Address: 1450 Mills Court Menlo Park, CA 94025 (650) 322-0240 Work Address:
Department of Neurology California Pacific Medical Center 2324 Sacramento Street, Suite 111 San Francisco, CA 94115 Phone: (415) 600-3604 Fax: (415) 673-5184
Cell: (650) 255-1210 EDUCATION AND TRAINING: The Johns Hopkins University Baltimore, MD 1980-1984 B.A. Tulane University School of Medicine New Orleans, LA 1984-1988 M.D. The Miriam Hospital, Brown University Providence, RI 1988-1989 Medical Internship University of Washington Seattle, WA 1989-1992 Resident in Neurology University of Texas, Southwestern Medical Center
Dallas, TX 1993-1994 Fellow in Neuromuscular Diseases
APPOINTMENTS: Director, Neuromuscular Clinic
California Pacific Medical Center Forbes Norris ALS-MDA Clinic
San Francisco, CA
4/2005 - present
Associate Professor Stanford University School of Medicine
Palo Alto, CA 7/04
Assistant Professor Stanford University School of Medicine
Palo Alto, CA 3/97- 6/04
Chairman, Pharmacy and Therapeutics Committee
Palo Alto VA Medical Center Palo Alto, CA 10/99-1/2004
Assistant Professor University of Texas, Southwestern Medical Center
Dallas, TX 1995
Clinical Instructor in Neurology University of Texas, Southwestern Medical Center
Dallas, TX 1994-1995
Jonathan Katz MD, CV, Page 2 of 11
Director EMG Lab Palo Alto VA Medical Center Palo Alto, CA
3/1997-3/2005
Neuromuscular Disease Clinic Stanford University Medical Center
Palo Alto, CA 3/1997-3/2005
Attending Physician Muscular Dystrophy Clinic
Stanford University Palo Alto CA 3/1997-3/2005
Attending Physician Palo Alto VA Medical Center Palo Alto CA 3/1997-3/2005
Director, Neurology Medical Student Course, Palo Alto VA
Palo Alto VA Medical Center Palo Alto CA 3/1997-3/2005
CURRENT CLINICAL DUTIES: Director, Neuromuscular Program, California Pacific Medical Center ALSA Clinic Director, Forbes-Norris MDA/ALS Research Center OTHER WORK EXPERIENCE: Neurologist Private Practice Pacific Grove, CA 1/96-1/97 MEDICAL LICENSURE: California A54410, since 9-1995 Texas J4874, expired 8-31-95 (moved) Washington 0029006, expired 5-14-94 (moved) BOARDS CERTIFICATION: American Board of Psychiatry and Neurology Specialty of Neurology, certificate # 39821 7/94 Added qualifications in clinical neurophysiology 6/96-6/06 (allowed to expire, intentionally) PROFESSIONAL ORGANIZATIONS: American Academy of Neurology, active member 1991-
California State Myasthenia Gravis Association 9/99-present Medical Advisory Board Guillain-Barre Foundation International. Medical Advisory 2004-present Board. FACULTY ORGANIZATIONS: Stanford University Medical School Faculty Senate
Senator 1998-2002 AWARDS: Lisia Forno award for outstanding teacher Department of Neurology, Stanford University SOM 2000-2001 CONSULTING:
Jonathan Katz MD, CV, Page 3 of 11
Blue Cross of California Consultant for IVIg usage for CIDP 4/2007-present Crescent Healthcare Consultant for administering IVIg database 4/2007-present Knowledge Industries, San Jose, CA 6/98- 8/2001 Medical consultant, Bayes Net development AskRed.com 1/00-9/2000 Consultant, Scientific Advisory Board
Diagnostic reasoning and Bayes Net development
AD HOC JOURNAL REVIEW: 1) Neurology 2) Muscle and Nerve 3) Archives of Neurology 4) Annals of Neurology 5) Lancet 6) Journal of Neurology 7) Neuromuscular Disorders ABSTRACTS: 8) Katz JS, Barohn RJ. Inclusion body myositis: Clinical and histological changes with
corticosteroid therapy. Journal of Child Neurology 1994; 9:204. 9) Katz JS, Ridings LW, Bryan WW, Jackson CE, Barohn RJ. The natural history of multifocal
motor neuropathy. Journal of Child Neurology 1994; 9:207-8.
11) Wolfe, GI, Katz JS, Bryan WW, and Barohn, RJ. Clinical features of primary lateral sclerosis.
Journal of Child Neurology 1995; 10:167. 12) Wolfe GI, Katz JS, Bryan WW, Wyans Jr. FH, and Barohn RJ. Antibodies in idiopathic
polyneuropathy and motor neuron disease. American Academy of Electrodiagnostic Medicine September 1995, Montreal.
13) Katz JS, Wolfe GI, Amato AA, Jackson CE, and Barohn RJ. Multifocal Motor Neuropathy: Is
conduction block a necessary feature. American Academy of Neurology. Neurology 1996;46:A234.
14) Amato AA, Gronseth GS, Jackson CE, Wolfe GI, Katz JS, Bryan WW, and Barohn RJ.
Inclusion-body myositis: Pattern of weakness and clinical features and evidence supporting the diagnosis of probable inclusion-body myositis. Neurology 1996;46:A486
15) Katz, JS, Bryan WW, Wolfe GI, Barohn RJ. The interpretation of acetylcholine receptor
antibodies in the Lambert-Eaton myasthenic syndrome. Neurology 1997;48:A64. 16) Katz JS, Bryan WW, Barohn RJ. “Bulbospinal muscular atrophy in adults without mutation on
the X-chromosome”. Journal of Child Neurology, 1997;12:
Multifocal acquired motor axonopathy. Neurology 2001;56:A397. 21) Katz JS, Amato AA, Barohn RJ. The Phenotype, Bayes Rule, and the Diagnosis of CIDP and
Diabetic Amyotrophy in Diabetic Patients. Presented in Denver, AAN 2002 22) Agosta, J. M. and Jonathan S. Katz, “The use of Evidence Conflict to extend Diagnostic Models”.
Information Refinement and Revision for Decision Making: Modeling for Diagnostics, Prognostics, and Prediction, Papers from the 2002 American Academy of Artificial Intelligence Spring Symposium, AAAI Technical Report SS-02-03, p.9.
23) Jonathan Katz, Palo Alto, CA, Richard Barohn, Kansas City, KS, Thomas Rando, Palo Alto, CA,
Carlayne Jackson, Matthew Wicklund, San Antonio, TX, David Saperstein, Kansas City, KS, Anthony Amato, Boston, MA. Distal muscular Dystrophy Affecting the Calves with Onset after Ate 30; Not Due to Dyferlinopathy. Neurology 2003; 60; A391.
24) Patrick M. Grogan, Stanford, CA, David Saperstein, Richard J. Barohn, Kansas City, KS, Yuen
So, Jonathan S. Katz, Stanford, CA. Nerve Conduction Studies in Clinically Defined Diabetic Amyotrophy. Neurology 2003; 60; A488.
25) Michelle Jorden, Palo Alto, CA, Richard J. Barohn, Kansas City, KS, Patrick Grogan, Greg
Nelson, Stanford, CA, Jonathan S. Katz, Palo Alto, CA. The Interpretation of Persistently Elevated Creatine Kinase Levels Following Discontinuation of Statin Drugs. Error! Not a valid link..
26) David S. Saperstein, Patrick M. Grogan, San Antonio, TX, Christopher Milford, April L. McVey,
Gil I. Wolfe, Sharon P. Nations, Dallas, TX, Laura L. Herbelin, Richard J. Barohn, Barry Skikne, Kansas City, KS, Hannes Vogel, Jonathan S. Katz, Palo Alto, CA Myeloneuropathy in the Setting of Myelodysplastic Syndrome Neurology 2004; 62; A196.
27) Diagnostic Criteria for Peripheral Neuropathies Using a Bayesian Network Truc P. Nguyen,
Jonathan S. Katz, Stanford, CA Neurology 2004; 62; A222. 28) Driving Ability in Neuropathy Patients S. Charles Cho, Sei-Gyung Kim, Anil Rama, San Jose,
CA, Jonathan Katz, Yuen T. So, Stanford, CA Neurology 2004; 62; A223-224. 29) Motor Nerve Ratios Distinguish Patients with Multifocal Motor Neuropathy from Amyotrophic
Lateral Sclerosis Kenneth C. Gorson, Jonathan S. Katz, Hocine Tighiouart, David Gershfield, Palo Alto, CA, Allan H. Ropper, Boston, MA Neurology 2004; 62; A378.
30) Outcome in Multifocal Motor Neuropathy: What Is the Risk of Developing Weakness in New
Nerve Distributions over Time? Jonathan S. Katz, Palo Alto, CA, Gil I. Wolfe, Dallas, TX, Kenneth C. Gorson, Boston, MA Neurology 2004; 62; A495.
Jonathan Katz MD, CV, Page 5 of 11
PRESENTATIONS: 1) Carrell-Krusen Symposium. "The natural history of multifocal motor neuropathy". Dallas, TX
1994. 2) Carrell-Krusen Symposium: "Case presentation: multifocal motor neuropathy
with symmetrical stocking and glove sensory loss". Dallas, TX 1994. 3) Carrell-Krusen Symposium: "The dropped head syndrome". Dallas, TX 1994. 4) American Academy of Neurology, Neuromuscular Dinner Seminar: "Isolated neck extensor
myopathy". Seattle, WA 1995. 5) American Academy of Neurology, Neuromuscular Dinner Seminar: "Adrenomyeloneuropathy".
Seattle, WA 1995. 6) Carrell-Krusen Symposium, February 1996 “Acetylcholine receptors and the Lambert-Eaton
atrophy” Dallas, TX. 8) American Academy of Neurology, 1998 Neuromuscular dinner seminar: “The spectrum
neuronopathy in sicca complex” Minneapolis, MN. 9) American Academy of Neurology, Neuromuscular after dinner seminar, 1999: “Brachial
amyotrophic diplegia (BAD).” 10) American Academy of Neurology, Neuromuscular after dinner seminar, 2000: “Multinodular
polymyosits.” 11) American Academy of Neurology, Neuromuscular after dinner seminar, 2001: “Idiopathic
Biphrenic neuropathy” 12) American Academy of Neurology, Neuromuscular after dinner seminar, 2001: “Diabetic
amyotrophy causing bilateral phrenic neuropathies” 13) American Academy of Artificial Intelligence, Spring Symposioium, 2002: “The Use of Evidence
Conflict to Extend Diagnostic Models.” Stanford University, Palo Alto, CA. INVITED LECTURES: 1) Grand Rounds, Stanford University Department of Neurosciences. December 1997: “Antibodies
in the evaluation of peripheral neuropathies” 2) Grand Rounds, Stanford University Department of Neurosciences. March 1998: “Clinically
guided electrodiagnosis: efficiencies and failures” 3) Stanford Symposium. November 1998: “Autoantibodies against peripheral nerve” 4) Grand Rounds. University of California, San Diego Medical Center. July 2000. “DADS
neuropathy.” 5) Grand Rounds. Stanford University. May 2000. “DADS neuropathy.”
Jonathan Katz MD, CV, Page 6 of 11
6) Grand rounds. University of Texas, Southwestern Medical center. May 2000: “ DADS neuropathy.”
7) Grand Rounds. University of Oregon. “Neuro-logic: Thoughts on disease categorization and
triage.” October 2000. 8) Grand Rounds. University of Kansas Medical Center. “DADS neuropathy,” March 2001 9) Grand Rounds. SUNY Upstate. “DADS neuropathy,” May 2001. 10) Grand Rounds NYU Medical Center. “DADS neuropathy,” May 2001. 11) Grand Rounds Ohio University Department of Neurology, “DADS neuropathy,” October 2001 12) Grand Rounds, Henry Ford Medical Center, Detroit MI, “A Bayesian Approach to Neuropathies”
November 2001 13) Grand Rounds, Stanford University Medical Center, “Analysis of a Case Using Bayesian
Networks and the Literature: Statin Induced Rhabdomyolysis or Polymyositis,” November 2001 14) California Neurological Association, “Analysis of Current CIDP Criteria” January 15, 2002. 15) Grand Rounds, University of Kansas Department of Neurology, “From ALS to BAD: Using
Bayes Rule to Know When to Update Medical Literature” March 2002 16) California Mysthenia Gravis Association Meeting. September 20, 2002. Clinical Aspects of
Autoimmune Diseases of the Peripheral Nervous System. 17) Grand Rounds, Columbia University Department of Neurology. Critical Analysis of Current CIDP
Criteria. October 6, 2002. New York, NY. 18) Guillain Barre Syndrome Foundation: 7th International Symposium. Invited speaker. November
22, 2002. Manhattan Beach, CA 19) San Francisco Neurology Association. Approach to Neuropathy. March 19, 2004. 20) California Pacific Medical Center Grand Rounds. Muscle Pain. Cramps, Statins, Fibromyalgia.
June 5, 2007. COURSES: 1) Course director: Variants of chronic
demyelinating polyneuropathies. Breakfast Seminar
American Academy of Neurology
2000-2002
2) Medical modeling workshop: A clinician’s approach to Bayesian networks
Stanford University, Dept. Engineering
February 7, 2001
3) Course director: Common and Uncommon Phenoypes in Neuromuscular Disease.
American Academy of Neurology
2003-2007
4) Course Participant: Neuromuscular Therapy Seminar: Treatment of CIDP
symmetric neuropathy. Neurology. 2000 ;54:615-20. 15) Hsia AW, Isaac K, Katz JS. Cauda equina syndrome from intradiscal electrothermal therapy
Neurology. 2000;55:320.
Jonathan Katz MD, CV, Page 8 of 11
16) Richardson S, Lopez F, Rojas S, Cho S, Holodniy M, Herndier B, Katz J. Multinodular polymyositis in a patient with human immunodeficiency and hepatitis C virus coinfection. Muscle Nerve 2001;24:433-437.
17) Saperstein DS, Katz JS, Amato AA, Barohn RJ Review: The clinical spectrum of chronic
acquired demyelinating polyneuropathies. Muscle Nerve 2001 ;24:311-24. Review. 18) Mendell JR, Barohn RJ, Freimer ML, et al. Randomized controlled trial of IVIg in untreated
chronic inflammatory demyelinating polyradiculoneuropathy. Neurology. 2001;56:445-449. 19) Katz JS, Saperstein DS. Asymmetric Acquired Demyelinating Polyneuropathies: MMN and
MADSAM. Current treatment options in neurology. 2001;3:119-125. 20) Katz JS, Barohn RJ. Update on the evaluation and treatment of autoimmune neuromuscular
disorders. Current treatment in myasthenia gravis. Rehab Clinics of North America. 2001; 12:381-389.
Herbelin LL, McVey AL, Katz JS. Myopathy with Skeletal Asymmetry and Hemidiaphragm Elevation is caused by mutations in the myotubularin gene. Neurology 2005; 64:1638-40.
Jonathan Katz MD, CV, Page 9 of 11
33) Lin PT, Andersson PB, Distad BJ, Barohn RJ, Cho SC, So YT, Katz JS. Bilateral isolated phrenic neuropathy causing painless bilateral diaphragmatic paralysis. Neurology. 2005 Nov 8;65(9):1499-501.
34) Grogan PM, Saperstein DS, Barohn RJ, So YT, Katz JS Electrodiagnostic Findings in Diabetic
Proximal Neuropathies. Muscle Nerve, submitted. Text book chapters: 1) Katz JS, Bryan WW, and Barohn, RJ. Infectious and granulomatous neuropathy. In: Samuels M
et al., eds. Office Practice of Neurology. New York: Churchill and Livingstone, 1996: 516-522. 2) Katz JS, Barohn RJ. Parapinous myopathies: Dropped head syndrome and bent spine syndromes.
In Katirji B et al. eds. Neuromuscular disorders in clinical practice. 2002 Boston, MA Butterworth-Heinemann: p 1181-1186.
3) Nations S, Katz JS, Barohn RJ. Infectious and granulomatous neuropathy. In: Samuels M et al.,
eds. Office Practice of Neurology [2nd ed.]. New York: Churchill and Livingstone, 2003: 597-604. 4) Saperstein DS, Amato AA, Katz JS, Barohn RJ. Immune-mediated Polyneuropathies. In:
L. Ed. In press. 6) Grogan P, Katz JS. Peripheral Neuropathy and Endocrine Disease. In: Handbook of peripheral
neuropathy. Bromberg M and Smith G Eds. Marcel-Dekker, New York NY. In press 7) Grogan PM, Katz JS. Vasculitic Neuropathy. In: Lynn DJ, Rae-Grant A, Newton HB, eds. The 5-
Minute Neurology Consult. Philadelphia: Lippincott Williams & Wilkins, in press. Website Development and Development of Criteria for CIDP: 1) Primary website developer and project participant. CIDP Validation Project Website. Case
sharing, voting, consensus tool for CIDP Validation Research Group. http://cidpvalidation.umaryland.edu/ . In this project, 13 world experts in CIDP discuss and use a statistical approach to analyze approximately 300 neuropathy cases to develop criteria for the diagnosis of CIDP.
2) IVIg usage criteria for Blue Cross of California and Wellpoint network Letters: 1) Katz JS, Wolfe GI, Bryan WW, Burns DK, Fleckenstein JW, and Barohn RJ. The differential
diagnosis of isolated neck extensor weakness and isolated neck extensor myopathy. Reply from the authors. Neurology 1997;48:550-551.
2) Katz JS, Wolfe GI, Bryan WW, Jackson CE, Amato AA, and Barohn RJ. Electrodiagnostic
findings in multifocal motor neuropathy. Reply from the authors. Neurology 1998;50:1936-7. 3) Martín Nogués, Josep Gamez, Agustin Codina, Carlos Cervera, Jonathan S. Katz, David S.
Saperstein, and Richard J. Barohn. Brachial amyotrophic diplegia. Neurology 2000 54: 2354-2357
Jonathan Katz MD, CV, Page 10 of 11
4) F. Todd Wetzel, Amie W. Hsia, Kathryn Isaac, and Jonathan S. Katz. Cauda equina syndrome
from intradiscal electrothermal therapy Neurology 2001 56: 1607 5) Daniel L. Menkes, Amitabha Ghosh, Michael Donaghy, Jonathan S. Katz, Richard J. Barohn,
David S. Saperstein, and Anthony A. Amato Axonal multifocal neuropathy without conduction block or other features of demyelination. Neurology 2002 59: 1666-1667.
Research/Research Opportunities: Basic Sciences Studies: ß-methylamino-L-alanine (BMAA) in the Hair. Sponsor: Investigator Initiated, start 2006 – ongoing (SI). Collection of Data and Biomaterial for repository Banking to Facilitate Research into the Etiology of ALS and related Motor Neuron Diseases. Sponsor: NIH;2006-ongoing (SI). Resequencing the variable Human Genome to Discover New Genes in ALS. Sponsor: MDA, 2005 (SI). Immunophenotypic Analysis, Viral Sequencing and the Use of Human Macrophages from Patients with Amyotrophic Lateral Sclerosis (ALS) and Alzheimer’s Disease (AD) in the Development of a Murine Model of ALS. Sponsor: National Cancer Institute, 2004-2005 (SI). Guillain-Barre Foundation, Philadelphia, PA.
California Pacific Medical Center Principle Investigator. Proposal to Develop and Validate Diagnostic Criteria for Chronic Inflammatory Demyelinating Polyneuropathy. Mona Baumgarten, Ph.D, Carol Koski. MD, David Cornblath, MD, Co-Principal Investigators.
NIH-Studies: Clinical Trial of Ceftriaxone in Subjects with ALS. Sponsor: NIH; 2005-still ongoing (PI). A multi-center, randomized, double-blind, phase II selection trial of combination therapy in 120 subjects with Amyotrophic Lateral Sclerosis (ALS). Sponsor: NIH; 2005-still ongoing (SI). Clinical Trial of High Dose Coenzyme Q10 in ALS Patients. Sponsor: NIH 2004-still ongoing (SI). A multi-center, phase III, randomized, double blind, placebo-controlled, clinical trial of minocycline in 400 subjects with ALS. Sponsor: NIH, Phase III 2003-ongoing (SI). A Trial of Insulin Like Growth Factor – 1 (IGF-1) in the Treatment of Patients with Amyotrophic Lateral Sclerosis (ALS). Sponsor: NIH, Phase III 2003-ongoing. (PI). Clinical Trial of Creatine in Amyotrophic Lateral Sclerosis (ALS). Sponsor: NIH and Avicena Group 2003-ongoing. MDA Sponsored: Web-based Registry. Amyotrophic Lateral Sclerosis Web-based Patient Care Database. 2003, ongoing. Corporate Sponsored:
Jonathan Katz MD, CV, Page 11 of 11
A Double-Blind, Randomized, Placebo – Controlled, Phase 1, Escalating Single Dose Study To Evaluate The Safety, Tolerability And Pharmacokinetics Of AEOL10150 Administered By Subcutaneous Injection In Patients With Amyotrophic Lateral Sclerosis. Sponsor: Aeolus Pharmaceuticals Phase 1 Study: 2004. Phase 2 Study A Double-Blind, Prospective, Randomized Comparison of MitoQ Tablets and Placebo Tablets for the Treatment of Patients with Friedreich Ataxia. Sponsor: Antipodean Pharmaceuticals, start 2006-ongoing (SI). Investigator Initiated Drug Studies: A 30-week, double-blind, placebo-controlled, crossover design study of Donepezil in the treatment of cognitive impairment in patients with Amyotrophic Lateral Sclerosis (ALS) Sponsor: Pfizer 2006-ongoing (PI). Biomarker of Cortical Impairment in Patients with ALS: A 4 Tesla Study. Sponsor: ALSA Grant # 1168 (PI). Past: Stanford Site Principle Investigator. Six Month (26 weeks) Double Blind, Randomized, Clinical Trial of Gentamicin in Duchenne Muscular Dystrophy Subjects with Stop Codon Mutations. Study Principal Investigator: Jerry Mendell. Coordinating Center: Ohio State University. Funded by the NINDS. Stanford Site Principle Investigator. Biogen Idec C-870 Study. Stanford/VA Site Principle Investigator. Funding: Biogen Inc. VPUE Faculty Grant for Undergraduate Research. Creating a belief network for predicting genetic mutations from the clinical phenotype in patients with peripheral neuropathy and developing diagnostic testing in this domain. With: Truc Nguyen, undergraduate student, 2002-3 and 2003-4. Pending: California Pacific Medical Center. Principle Investigator. Thymectomy trial in non-thymomatous Myasthenia Gravis. Primary Principal Investigator: John Newsome-Davis. Coordinating Center: Oxford, England. Funding pending NINDS.
Revised, partially July 2007
CURRICULUM VITAE
LORNE H. ZINMAN, MD, MSc, FRCPC Assistant Professor of Neurology, University of Toronto
Sunnybrook Health Sciences Centre 2075 Bayview Avenue, SCIL – Rm UG26
• University of Toronto (September 2003 – May 2005) Master of Science (Clinical Epidemiology) Department of Health Policy Management and Evaluation
• University of Toronto (July 2003 – June 2005) Clinical and Research Fellowship – Neuromuscular Diseases Division of Neurology Supervisor: Drs. V. Bril and P. O’Connor
• University of Toronto (1998-03) Neurology residency training program
• University of Calgary (1995-98) Doctor of Medicine
• Queen's University (1993-95) Master of Science (Neurobiology) Supervisors: Drs. R.J. Riopelle (Neurology) and D.H. Maurice (Pharmacology)
• University of Toronto (1989-93) Bachelor of Science with Distinction (Human Biology/Physiology) CERTIFICATION:
• 2004 – Certification in Electromyography (EMG) – Canadian Society of Clinical Neurophysiologists
• 2003 – Certification in the specialty of Neurology - Royal College of the Physicians and Surgeons of Canada (RCPSC)
• 1999 – The Medical Council of Canada Qualifying Examination Part II • 1998 – The Medical Council of Canada Qualifying Examination Part I
Updated May 2007 1
EMPLOYMENT HISTORY:
• 2006- – Board of Directors Member, ALS Society of Ontario
• 2005- – Assistant Professor of Medicine (Neurology), University of Toronto
• 2005- – Associate Scientist, Clinical Epidemiology, Sunnybrook Research Institute
• 2005- – Staff Neurologist, Sunnybrook Health Sciences Centre, Toronto
• 2005- – Medical Director, Sunnybrook ALS/Neuromuscular Clinic
• 2005- – Director, Sunnybrook EMG Laboratory
• 2005- – Co-Director, Sunnybrook Neurophysiology Unit
• 2003-05 – Clinical and Research Fellow, Division of Neurology, University of Toronto
• 2002-03 – Chief Neurology Resident, University of Toronto
SCHOLARSHIPS AND AWARDS:
• PAIRO Resident Teaching Award – University of Toronto Recipient (2003) – Resident Teaching Excellence
• American Academy of Neurology Resident Scholarship (2003) – Excellence in Neurology Teaching and Education
• University of Calgary, Joseph Albert Award (1997) – Academic award for elective study
• Queen's University Dean's Award (1994) – Academic excellence in graduate studies
• Queen’s Graduate Award (1994) – Academic excellence in graduate studies
• Queen's University Eldon Boyd Fellowship (1994) – High academic performance and research accomplishments
Updated May 2007 2
• Queen's University, Dept. of Pharmacology Outstanding Teaching Assistant Award (1994) – Elected by undergraduate Life Sciences students
• Graduation with Distinction, University of Toronto (1993)
• University of Toronto T-Holders Academic and Athletic Excellence Award (1992,93) – Academic excellence and participation in University Football
• University of Toronto Rita K. Teetzel In-Course Academic Scholarship (1992)
• Easter Seal Summer Student Research Scholarship (1992)
• Volunteer Service Award - Doctors Hospital, Toronto (1991)
• University of Toronto Varsity Letter (1990) – Participation in University Football
• York University Merit Award (1989) – Declined PROFESSIONAL ORGANIZATIONS: • North Eastern ALS (NEALS) Research Consortium
• Western ALS (WALS) Research Consortium
• American Association of Neuromuscular and Electrodiagnostic
Medicine (AANEM)
• Canadian Society of Clinical Neurophysiologists
• Royal College of Physicians and Surgeons of Canada
• Ontario Medical Association
Updated May 2007 3
RESEARCH PUBLICATIONS: Refereed Manuscripts: S. Xiao, H.S. Pall, E.F. Goodall, T. Kawarai, L.H. Zinman, C. Sato, J.
Robertson, K. Morrison, E. Rogaeva. Genetic Studies of GRN and IFT74 in Amyotrophic Lateral Sclerosis. Neurobiology of Aging March 22, 2007.
L. Zinman, E. Ng and V. Bril. IV Immunoglobulin in Patients with Myasthenia Gravis: A Randomized Controlled Trial. Neurology 68:837-41, 2007.
J. Perry, L. Zinman and N. Laperriere. The Use of Prophylactic Anticonvulsants in Patients with Brain Tumours: A Systematic Review. Current Oncology 13:222-29, 2006.
L.H. Zinman, P.W. O’Connor, K.E. Dadson, R.C. Leung, M. Ngo, V. Bril. Sensitivity of Repetitive Facial‐Nerve Stimulation in Patients with Myasthenia Gravis. Muscle and Nerve 33:694‐696, 2006.
L.H. Zinman, D. Sutton, E. Ng, P. Nwe, M. Ngo, V. Bril. A Pilot Study to Compare the Use of Excorim Staphylococcal Protein Immunoadsorption System and IVIG in Chronic Inflammatory Demyelinating Polyneuropathy. Transfusion and Apheresis Science 33:317-24, 2005.
L.H. Zinman, V. Bril and B.A. Perkins. Cooling Detection Thresholds
in the Assessment of Diabetic Sensory Polyneuropathy: Comparison of CASE IV and Medoc Instruments. Diabetes Care 27:1674-9, 2004.
L.H. Zinman, M. Ngo, E. Ng, P. Nwe, S. Gogov, S. Skandarajah, V.
Bril. Low-Intensity Laser Therapy for the Treatment of Painful Diabetic Neuropathy. Diabetes Care 27:921-4, 2004.
Black SE, Freedman M. Recognizing the non-Alzheimer’s Dementias: Highlights from the University of Toronto Behavioral Neurology Clinic Day. Geriatrics and Aging 7:53-9, 2004.
Updated May 2007 4
Zinman L.H., Lawrance G., Wang W., Verge V.M.K., Dow K.E., Maurice
D.H., Richardson P.M. and Riopelle R.J. Collaborative and Reciprocal Effects of Ciliary Neurotrophic Factor and Nerve Growth factor on the Neuronal Phenotype of Human Neuroblastoma Cells. J. Neurochem. 70: 1411-20, 1998.
Zinman L.H. Characterization of Choline Acetyltransferase Activity
Regulation by Ciliary Neurotrophic Factor in the LA-N-2 Neuroblastoma Cell Line. Master of Science Thesis. Queen’s University, Kingston, Ontario, 1995.
Updated May 2007 5
Refereed Abstracts and Presentations: L. Zinman. The Effectiveness of IVIG Treatment in Myasthenia Gravis.
Presented at the 11th International Conference on Myasthenia Gravis and Related Disorders, Chicago, Illinois May 16, 2007
L. Zinman. Are Statin Medications Safe in Patients with ALS? Presented at The ALS Society of Canada Annual Research Forum. March 24, 2007.
L. Zinman. ALS Clinical Features and Patient Presentation. Presented at The ALS Society of Canada Annual Research Forum. March 23, 2007.
L. Zinman. Basic Principles and Clinical Utility of EMG in Neuromuscular Diseases. University of Toronto Neurosurgery Resident Rounds. March 9, 2007.
F. Ezerzer, K. Hall, M. Moore, T. Dharas, M. Gawel and L. Zinman. Telepractice: Improving Access to Interdisciplinary Care for People with ALS. The ALS Association Clinical and Leadership Conference, Newport Beach, California January 25‐27, 2007.
L. Zinman. Are Statin Medications Safe in Patient’s with ALS? A Prospective Cohort Study. Presented at the University of Toronto Annual Neuromuscular Day, October 20, 2006.
L.H. Zinman and V. Bril. Comparison of Electrophysiological Studies and Clinical Evaluation as Measures of Treatment Response in Patients with Myasthenia Gravis. Presented at The 28th International Congress of Clinical Neurophysiology, Edinburgh, Scotland, September 10-14, 2006.
L.H. Zinman and V. Bril. Is IVIG an Effective Treatment For Patients with Myasthenia Gravis? Presented at Sunnybrook Neurosciences Rounds, University of Toronto June 8, 2006.
Updated May 2007 6
L.H. Zinman. An Approach to Peripheral Neuropathies. Presented at
Sunnybrook Internal Medicine Resident Rounds, University of Toronto, May 11, 2006.
L.H. Zinman. Diabetic Neuropathy: Update on Diagnosis and Management. Presented at Sunnybrook and Women’s College Endocrinology Grand Rounds, University of Toronto, May 3, 2006.
L.H. Zinman. Neuromuscular Complications of Renal Disease.
Presented at Sunnybrook and Women’s Nephrology Rounds, University of Toronto, January 16, 2006.
L.H. Zinman. EMG and Nerve Conduction Studies for the Diagnosis of
Neuromuscular Diseases: Basic Principles and Interesting Cases. Presented at Sunnybrook and Women’s College Family Medicine Practice Rounds, University of Toronto, November 23, 2005.
L.H. Zinman and V. Bril. The Effectiveness of IVIG in Patients with
Myasthenia Gravis. Presented at the University of Toronto Annual Neuromuscular Day, November 4, 2005.
L.H. Zinman. Neuromuscular Morbidity and Mortality Case Presentation. Presented at the University of Toronto Annual Neuromuscular Day, November 4, 2005.
L.H. Zinman. Diabetic Neuropathy: Diagnosis, Management and Novel Interventions. Presented at Sunnybrook and Women’s College Physiatry Grand Rounds, University of Toronto, October 14, 2005.
L.H. Zinman. ALS and Motor Neuron Diseases. Presented at University of Toronto Neurology Resident Teaching Rounds, September 30, 2005.
L.H. Zinman. Shocking Neuromuscular Cases: Electrodiagnostic Testing in Neurology. Presented at Sunnybrook and Women’s College Medical Grand Rounds, University of Toronto, September 22, 2005.
L.H. Zinman. The Effectiveness of IVIG in Patients with Myasthenia Gravis: A Randomized Clinical Trial. Presented at the University of Toronto J.L. Silversides Day, June 22, 2005.
Updated May 2007 7
L.H. Zinman and V. Bril. IVIG Compared to Placebo in Patients with Myasthenia Gravis: A Randomized Controlled Trial. Presented at the University of Toronto Neuromuscular Academic Day, October 29, 2004.
L. Zinman and V. Bril. Non-Pharmacological Therapy for Painful Diabetic Neuropathy. Presented at the University of Toronto Annual Neuromuscular Day, October 17, 2003.
L.H. Zinman, R. Silver and S.M.H. Alibhai. A Case of Hypoglycemia
and Reversible Dementia In A Young Man. University of Toronto Department of Internal Medicine Case Competition, 2001.
Zinman L.H. and Fletcher W.A. The projection of nasal and temporal
retinal ganglion cells in humans. Presented at the American Academy of Neurology Annual Meeting, Minneapolis, Minnesota; Neurology 50, Supplement 4, A4-5, 1998.
Zinman L.H. and Fletcher W.A. Homonymous hemianopia and the
vertical meridian. Presented at the North American Neuro-Ophthalmology Society 24th annual meeting, Orlando, Florida 1998.
Zinman L.H., Maurice D.H. and Riopelle, R.J. Characterization of
choline acetyltransferase regulation by ciliary neurotrophic factor in the LA-N-2 neuroblastoma cell line. Society for Neuroscience, 20:668 (#286.2), 1994.
Zinman L.H., Verge V.M.K., Maurice D.H. and Riopelle R.J. Ciliary
neurotrophic factor induction of choline acetyltransferase activity, protein levels and gene expression in a human neuroblastoma cell line. Canadian Federation of Biological Societies (#72), 1995.
Lawrance G., Zinman L.H., Verge V., Richardson P. and Riopelle R.
Induction of TrkA by CNTF mediates signalling and differentiation effects of NGF in human neuroblastoma. Neuroscience Network Annual Meeting (#22), 1995.
Zinman L.H., Verge V.M.K., Maurice D.H. and Riopelle, R.J. Ciliary
neurotrophic factor induction of choline acetyltransferase gene expression in a model neuronal cell line Neuroscience Network Annual Meeting (#63), 1995.
Maurice D.H., Riopelle R.J. Inductive influences of CNTF on neuronal gene and phenotype expression. Society for Neuroscience, 21:1053 (#419.17) 1995.
Updated May 2007 9
Zinman L.H., Szekrenyes J. and Cruse P. Sir Marc Ruffer (1859-1917)
and Paleopathology. Canadian Society for the History of Medicine - Annual Conference (Learned Society), Brock University, St. Catharines, Ontario, 1996.
