Peng Wei - University of Texas School of Public Health

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Curriculum Vitae of Peng Wei

Department of Biostatistics and Human Genetics Center

School of Public Health

University of Texas Health Science Center at Houston

1200 Pressler Street, RAS E-817

Houston, TX 77030

Phone: (713) 500- 9565 Fax: (713) 500-9530

Email: [email protected]

EDUCATION

2009 PhD, Biostatistics, University of Minnesota, Minneapolis, MN, USA

2006 MS, Biostatistics, University of Minnesota, Minneapolis, MN, USA

2004 BS, Statistics, School of Mathematical Sciences, Peking University, China

PROFESSIONAL EXPERIENCE

Associate Professor with tenure

September 2015 – present

Department of Biostatistics and Human Genetics Center, School of Public Health, University

of Texas Health Science Center at Houston

Tenure-track Assistant Professor

July 2009 – August 2015

Department of Biostatistics and Human Genetics Center, School of Public Health, University

of Texas Health Science Center at Houston

Research Assistant

2005 – 2009

Division of Biostatistics, School of Public Health, University of Minnesota

2005 – 2008

Department of Medicine, Medical School, University of Minnesota

2004 – 2005

Coordinating Centers for Biometric Research (CCBR), University of Minnesota

Teaching Assistant

2004 – 2005

Division of Biostatistics, School of Public Health, University of Minnesota

Summer Intern, 2007 Amgen, Inc.

HONORS, AWARDS AND FELLOWSHIPS

2011 Travel Award to the Fourth IMS (International Institute of Mathematical Statistics)

and ISBA (International Society for Bayesian Analysis) Joint Meeting Park City, Utah

2010 PRIME Award for New Investigators School of Public Health, University of Texas

Health Science Center at Houston

2010 Travel Award to ENAR Workshop for Junior Researchers

2009 Jacob E. Bearman Student Achievement Award Division of Biostatistics, University

of Minnesota

2009 ENAR Distinguished Student Paper Award The International Biometric Society

(IBS)/ Eastern North American Region (ENAR)

2008-2009 Doctoral Dissertation Fellowship University of Minnesota Graduate School

2006 Outstanding Research Assistant Division of Biostatistics, University of Minnesota

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2004 New Student Fellowship Division of Biostatistics, University of Minnesota

2004 Outstanding Graduate Peking University, Beijing, China

PEER REVIEWED PUBLICATIONS

Wei’s graduate student; *: First or co-first Author; #: Corresponding or co-corresponding author.

1. Cao, Y., Maxwell, T.J., Wei, P.# (2015) A family-based joint test for mean and variance

heterogeneity for quantitative traits. Annals of Human Genetics, 79:46-56. [PMCID:

PMC4275359].

2. Pan, W.#, Kwak, I.Y., Wei, P.# (2015) A powerful pathway-based adaptive test for genetic

association with common or rare variants. American Journal of Human Genetics,

97(1):86-98. [PMCID: PMC4572508].

3. Wei, P.*, Yang, Y.*, Guo, X., Hei, N., Lai, S., Assassi, S., Liu, M., Tan, F., Zhou, X. (2015)

Integrative studies of scleroderma-associated genetic and environmental factors with

fibroblasts identify polymorphisms of TNFAIP3 in association with MMP expression.

Arthritis & Rheumatology (in press).

4. Dong, C.*, Wei, P.*, Jian, X., Gibbs, R.A., Boerwinkle, E., Wang, K., Liu, X. (2015)

Comparison and integration of deleteriousness prediction methods for nonsynonymous SNVs

in whole exome sequencing studies. Human Molecular Genetics, 24:2125-2137. [PMCID:

PMC4375422].

5. Wang, Y., Li, D., Wei, P.# (2015) Powerful Tukey's one-degree-of-freedom test for detecting

gene-gene and gene-environment interactions. Cancer Informatics, 14(Suppl 2):209–218.

[PMCID: PMC4459566].

6. Kim, T., Wei, P.# (2015) Incorporating ENCODE information into association analysis of

whole genome sequencing data. BMC Proceedings (in press).

7. Pan, W.#, Chen, Y.M., Wei, P.# (2015) Testing for polygenic effects in genome-wide

association studies. Genetic Epidemiology, 39:306-316. [PMCID: PMC4406854].

8. Ware, R.R., Davis, B.R., Schultz, W.H., Brown, R.C., Aygun, B., Sarnaik, S., Odam, I., Fuh,

B., George, A., Owen, W., Luchtman-Jones, L., Rogers, Z.R., Hilliard, L., Gauger, C.,

Piccone, C., Lee, M.T., Kwiatkowski, J.L., Jackson, S., Miller, S.T., Roberts, C., Heeney,

M.M., Kalfa, T.A., Nelson, S., Imran, H., Nottage, K., Alvarez, O., Rhodes, M., Thompson,

A.A., Rothman, J.A., Helton, K.J., Roberts, D., Coleman, J., Bonner, M.J., Kutlar, A., Patel,

N., Wood, J., Piller, L., Wei, P., Luden, J., Mortier, N.A., Stuber, S.E., Luban, N.L.C., Cohen,

A.R., Pressel, S., Adams, R.J. (2015) Hydroxycarbamide versus chronic transfusion for

maintenance of transcranial doppler flow velocities in children with sickle cell

anaemia—TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre,

open-label, phase 3, non-inferiority trial. The Lancet (in press).

9. Yu, B., Li, A.H., Muzny, D., Veeraraghavan, N., de Vries, P., Bis, J.C., Alexander, D.,

Morrison, A.C., Dehghan, A., Psaty, B.M., Gibbs, R., Wei, P.*, Boerwinkle, E. (2015)

Association of Rare Loss-Of-Function Alleles in HAL, Serum Histidine Levels and Incident

Coronary Heart Disease. Circulation Cardiovascular Genetics, 8:351-355. (*senior author).


10. Xu, L., Tang, H., Chen, D.W., El-Naggar, A.K., Wei, P.*, Sturgis, E.M. (2015)

Genome-Wide Association Study Identifies Common Genetic Variants Associated with

Salivary Gland Carcinoma and its Subtypes. Cancer, 121(14):2367-74. (*senior author).

[PMC in process].

11. Xu, L., Tang, H., El-Naggar, A.K., Wei, P.*, Sturgis, E.M. (2015) Genetic variants in DNA

double-strand break repair genes and susceptibility to salivary gland carcinoma: a

case-control study. PLoS ONE, 10(6):e0128753. (*senior author). [PMCID: PMC4452711].

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12. Schick, U.M., Auer, P.L., Bis, J.C., Lin, H., Wei, P., Pankratz, N., Lange, L.A., Brody, J.,

Stitziel, N.O, Kim, D.S., Carlson, C.S., Fornage, M., Haessler, J., Hsu, L., Jackson, R.D.,

Kooperberg, C., Leal, S.M., Psaty, B.M., Boerwinkle, E., Tracy, R., Ardissino, D., Shah, S.,

Willer, C., Loos, R., Melander, O., McPherson, R., Hovingh, K., Reilly, M., Watkins, H.,

Direlli, D., Fontanillas, F., Chaseman, D.I., Gabriel, S.B., Gibbs, R., Nickerson, D.A.,

Kathiresan, S., Peters, U., Dupuis, J., Wilson, J.G., Rich, S.S., Morrison, A.C., Benjamin,

E.J., Gross, M.D., Reiner, A.P. (2015) Association of Exome Sequences with Plasma

C-reactive Protein levels in >9,000 Participants. Human Molecular Genetics, 24:559-571.


13. Liu, X., White, S., Peng, B., Johnson, A., Brody, J., Li, A., Huang, Z., Carroll, A., Wei, P.,

Gibbs, R., Klein, R., Boerwinkle, E. (2015) WGSA: an annotation pipeline for human

genome sequencing studies. Journal of Medical Genetics (in press).

14. Wei, P.#, Tang, H., Li, D. (2014) Functional logistic regression approach to detecting gene by

longitudinal environmental exposure interaction in a case-control study. Genetic

Epidemiology, 38(7):638-651. [PMCID: PMC4189963].

15. Cao, Y.*, Wei, P.*, Bailey, M., Kauwe, J.S.K., Maxwell, T.J. (2014) A versatile omnibus

test for detecting mean and variance heterogeneity. Genetic Epidemiology, 38:51-59.


16. Tang, H., Wei, P., Duell, E.J., Risch, H.A., Olson, S.H., Bueno-de-Mesquita, H.B., Gallinger,

S., Holly, E.A., Petersen, G., Bracci, P.M., McWilliams, R.R., Jenab, M., Riboli, E.,

Tjønneland, A., Boutron-Ruault, M.C., Kaaks, R., Trichopoulos, D., Panico, S., Sund, M.,

Peeters, P.H., Khaw, K., Amos, C.I., Li, D. (2014) Genes-environment interactions in

obesity- and diabetes-associated pancreatic cancer risk: A GWAS data analysis. Cancer

Epidemiology, Biomarkers & Prevention, 23:98-106. [PMCID: PMC3947145].

17. Tang, H., Wei, P., Duell, E.J., Risch, H.A., Olson, S.H., Bueno-de-Mesquita, H.B., Gallinger,

S., Holly, E.A., Petersen, G., Bracci, P.M., McWilliams, R.R., Jenab, M., Riboli, E.,

Tjønneland, A., Boutron-Ruault, M.C., Kaaks, R., Trichopoulos, D., Panico, S., Sund, M.,

Peeters, P.H., Khaw, K., Amos, C.I., Li, D. (2014) Axonal guidance signaling pathway

interacting with smoking in modifying the risk of pancreatic cancer: A gene and

pathway-based interaction analysis of GWAS data. Carcinogenesis, 35:1039-1045. [PMCID:

PMC4004205].

18. Pan, W.#, Kim, J., Zhang, Y., Shen, X. Wei, P.# (2014) A powerful and adaptive association

test for rare variants. Genetics, 197:1081-1095. [PMCID: PMC4125385].

19. Zhang, C., Sturgis, E., Zheng, H., Song, X., Wei, P., Jin, L., Li, C., Wei, Q., Li, G. (2014)

Genetic variants in TNF-α promoter are predictors of recurrence in patients with squamous

cell carcinoma of oropharynx after definitive radiotherapy. International Journal of Cancer,

134(8):1907-1915. [PMCID: PMC3947426].

20. Yang, Y.*, Wei, P.*, Guo, X., Zhou, D., Assassi, S., Zhou, X. (2013) Impact of age and

autoantibody status on the gene expression of scleroderma fibroblasts in response to silica

stimulation. European Journal of Inflammation, 11:631-639. [PMCID: PMC4244759].

21. Grimes, C., Hwang, L.Y., Wei, P., Shah, D., Volcik, K., Brown, E.L. (2013) Differentially

regulated gene expression associated with Hepatitis C viral clearance. Journal of General

Virology, 94:534-542. [PMCID: PMC3709607].

22. Jin, L., Sturgis, E., Zhang, Y., Huang, Z., Wei, P., Guo, W., Wang, Z., Wei, Q., Song, X, Li, G.

(2013) Genetic variants in p53-related genes confer susceptibility to second primary

malignancy in patients with index squamous cell carcinoma of head and neck.

Carcinogenesis, 34(7):1551-1557. [PMCID: PMC3697893].

23. Chen, Y., Luo, S., Chu, H, Wei, P. (2013) Bayesian inference on risk differences: an

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application to multivariate meta-analysis of adverse events in clinical trials. Statistics in

Biopharmaceutical Research, 5:142-155. [PMCID: PMC3706106].

24. Johnsen, J.M., Auer, P.L., Morrison, A.C., Jiao, S., Wei, P., Fox, K., Carlson, C.S, Smith, N.,

Boerwinkle, E., Kooperberg, C., Nickerson, D., Rich, S.S., Green, D., Peters, U., Cushman,

M., Reiner, A. (2013) Common and rare VWF coding variants, von Willebrand factor levels,

and factor VIII levels in African Americans: the NHLBI exome sequencing project. Blood,

122:590-597. [PMCID: PMC3724194].

25. Nischal, H., Sun, H., Wang, Y., Ford, D.A., Cao, Y., Wei, P., Teng, B.B. (2013) Long-term

expression of apolipoprotein B mRNA-specific hammerhead ribozyme via scAAV8.2 vector

inhibits atherosclerosis in mice. Molecular Therapy - Nucleic Acids, 2, e125. [PMCID:

PMC4027429].

26. Wei, P.*, Tang, H*, Li, D. (2012) Insights into pancreatic cancer etiology from pathway

analysis of genome-wide association study data. PLoS ONE, 7:e46887. [PMCID:

PMC3464266].

27. Wei, P.#, Pan, W. (2012) Bayesian joint modeling of multiple gene networks and diverse

genomic data to identify target genes of a transcription factor. The Annals of Applied

Statistics, 6:334-355. [PMCID:PMC3298193]

28. Wei, P.#, Liu, X. Fu,Y.X. (2011) Incorporating predicted functions of nonsynonymous

variants into gene-based analysis of exome sequencing data: a comparative study. BMC

Proceedings, 5:S20. [PMCID: PMC3287855]

29. Chen, G.K.*, Wei, P.*, DeStefano, A.L. (2011) Incorporating biological information into

association studies of sequencing data. Genetic Epidemiology, 35:S29-S34. [PMCID:

PMC3635488].

30. Wei, P.*, Milbauer, L.C.*, Enenstein, J.*, Nguyen, J., Pan, W., Hebbel, R.P. (2011)

Differential endothelial cell gene expression by African Americans versus Caucasian

Americans: a possible contribution to health disparity in vascular disease and cancer. BMC

Medicine, 9:2. [PMCID: PMC3029215].

31. Wei, P.#, Pan, W. (2010) Network-based genomic discovery: application and comparison of

Markov random field models. Journal of the Royal Statistical Society: Series C (Applied

Statistics), 59:105-125. [PMCID: PMC3046412].

32. Enenstein, J., Milbauer, L., Domingo, E., Wells, A., Roney, M., Kiley, J., Wei, P., Hebbel,

R.P. (2010) Proinflammatory phenotype with imbalance of KLF2 and RELA: risk of

childhood stroke with sickle cell anemia. American Journal of Hematology, 85:18-23.

33. John, R., Panch, S., Harbe, J., Wei, P., Solovey, A., Hebbel, R. (2009) Activation of

endothelial and coagulation systems in left ventricular assist device recipients. The Annals of

Thoracic Surgery, 88:1171-1179.

34. Wei, P., Pan, W. (2008) Incorporating gene networks into statistical tests for genomic data

via a spatially correlated mixture model. Bioinformatics, 24(3):404-411.

35. Wei, P., Pan, W. (2008) Incorporating gene functions into regression analysis of

DNA-protein binding data and gene expression data to construct transcriptional networks.

IEEE/ACM Transactions on Computational Biology and Bioinformatics, 5(3):401-415.

36. Milbauer, L.C.*, Wei, P.*, Enenstein, J.*, Jiang, A.*, Hillery, C.A., Scott, J.P., Nelson, S.C.,

Bodempudi, V., Topper, J.N., Yang, R.B., Hirsch, B., Pan, W., Hebbel, R.P. (2008) Genetic

endothelial systems biology of sickle stroke risk. Blood, 111(7):3872-3879. (*contributed

equally). [PMCID: PMC2275038].

37. Pan, W., Wei, P., Khodursky, A. (2008) A parametric joint model of DNA-Protein binding,

gene expression and DNA sequence data to detect target genes of a transcription factor.

Pacific Symposium on Biocomputing (PSB) 2008:465-476.

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38. Li, N., Wu, B., Wei, P., Xie, B., Xie, Y., Xiao, G., Pan, W. (2007) Functional group-based

linkage analysis of gene expression trait loci. BMC Proceedings 2007, 1(Suppl 1):S117.

39. Huang, D., Wei, P., Pan,W. (2006) Combining gene annotations and gene expression data in

model-based clustering: weighted method. OMICS: A journal of Integrative Biology,

10(1):28-39.

SELECTED MANUSCRIPTS UNDER REVIEW/REVISION

Wei’s graduate student; *: First or co-first Author; #: Corresponding or co-corresponding author.

40. Cao, Y., Rajan, S.S., Wei, P.# (2015) Mendelian randomization analysis of a time-varying

exposure for binary disease outcomes using functional data analysis methods. Under review.

41. Xu, G., Lin, L., Wei, P., Pan, W. (2015) An adaptive two-sample test for high-dimensional

means. Revision under review.

42. Li, D., Tang, H., Wei, P., Wolff, R., Hassan, M.M. (2015) Heterocyclic Amine Exposure and

Risk of Pancreatic Cancer: A Large Case-Control Study. Under review.

43. Li, G., Sun, Y., Sturgis, E., Wei, P., Song, X., Lei, D., Wei, Q., Zheng, H. (2015) Site

disparities in apoptotic variants as predictors of risk for second primary malignancy in

patients with squamous cell carcinoma of the head and neck. Under review.

44. Pankratz, N., Wei, P., Brody, J.A., Chen, M.H., de Vries, P.S., Huffman, J.E., Auer, P.L.,

Boerwinkle, E., Cushman, M., de Maat, M.P.M., Folsom, A.R., Franco, O.H., Gibbs, R.A.,

Haagenson K.K., Hofman, A., Johnsen, J.M., Kovar, C.L., Kraaij, R., McKnight, B., Metcalf,

G.A., Muzny, D., Psaty, B.M., Tang, W., Uitterlinden, A.G., van Rooij, J.G.J., Veeraraghavan,

N., Dehghan, A., O’Donnell, C.J., Reiner, A.P., Smith, N.L., and Morrison, A.C. (2015)

Whole exome sequencing of 14,000 individuals identifies novel rare variation associated

with hemostatic factors. Under revision.

GRANT SUPPORT

Current Grant Support

Title: Genetic Susceptibility and Risk Model for Pancreatic Cancer

Funding Source: NIH/NCI (R01 CA169122)

Role: Principal Investigator (30% effort)

Duration: 9/17/2013 – 5/31/2017

Total direct cost: $ 858,148 + indirect cost

Title: Association Analysis of Rare Variants with Sequencing Data

Funding Source: NIH/NHLBI (R01 HL116720)


Multiple PI: Peng Wei/Wei Pan

Duration: 9/1/2013 – 5/31/2016

Total direct cost: $ 842,220 + indirect cost

Title: Genome-wide Gene-by-Smoking Interaction Analysis of Pulmonary Function



Multiple PI: Peng Wei/Alanna C. Morrison

Duration: 12/15/2014-11/30/2017

Total direct cost: $300,000 + indirect cost

Title: Using Biomedical Knowledge to Identify Plausible Signals for Pharmacovigilance

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Funding Source: NIH/NLM (R01 LM011563)

Role: Co-Investigator (5% effort)

Principal Investigator: Trevor Cohen

Duration: 9/1/2013 – 8/31/2016

Title: An Integrated Genetic and Epigenetic Approach to Cerebral Small Vessel Disease

Funding Source: NIH/NINDS (R01 NS087541)


Multiple PI: Myriam Fornage/Eric Boerwinkle

Duration: 4/1/2014-3/31/2018

Title: Impact of Amino Acid Variants and Interactions on Lipid Profiles and Incident CHD



Principal Investigator: Taylor Maxwell

Duration: 6/1/2012-12/31/2015

Title: Inflammatory Response miRNAs Predict HPV-associated Oropharyngeal Cancer

Outcome

Funding Source: NIH/NCI (R03CA186261)

Role: Subcontract PI

Principal Investigator: Guojun Li (UT MD Anderson Cancer Center)

Duration: 4/1/2015 – 3/31/2017

Completed Grant Support

Title: Systems Biology and Network Approaches to Dissecting Complex Diseases

Funding Source: University of Texas School of Public Health (PRIME award)

Role: Principal Investigator

Duration: 9/1/2010 – 8/31/2011

Total cost: $24,852

Title: Statistical Methods for Finding Missing Heritability


Role: Co-investigator (5% effort)

Principal Investigator: Momiao Xiong

Duration: 1/10/2011 – 12/31/2014

Title: Building on GWAS for NHLBI-Disease: The CHARGE Consortium

Funding Source: NIH (RC2 HL102419)


Principal Investigator: Eric Boerwinkle

Duration: 10/1/2011 – 9/30/2012

Title: Genetics of Hypertensive Associated Treatments (GENHAT)



Principal Investigator: Charles E .Ford

Duration: 7/1/2010 – 8/31/2012

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Title: TCD with Transfusions Changing to Hydroxyurea (TWiTCH) Phase III Clinical Trial



Principal Investigator: Barry Davis

Duration: 9/1/2011-03/31/2015

Title: Statistical Methods for Genomic and Proteomic Data


Role: Research Assistant

Principal Investigator: Wei Pan

Duration: 1/10/2005 – 6/30/2009

Title: Genetic Heterogeneity in Endothelial Gene Expression

Funding Source: NIH/NHLBI (P01 HL076540-050004)

Role: Research Assistant

Principal Investigator: Robert P Hebbel

Duration: 8/31/2005 -8/29/2008

PRESENTATIONS

Invited Presentations

1. “Network-based Mixture Models for Genomic Data”. Department of Biostatistics seminar

series, Vanderbilt University, Nashville, TN. September 9, 2008.

2. “Network-based Mixture Models for Genomic Discovery” Department of Biostatistics

seminar series, University of North Carolina, Chapel Hill. February 9, 2009.

3. “Network-based Mixture Models for Genomic Discovery” Division of Biostatistics seminar

series, University of Minnesota, Twin Cities. Minneapolis, MN. February 18, 2009.

4. “Network-based Mixture Models for Genomic Discovery” Department of Global

Biostatistics and Epidemiology, Amgen, Inc., Seattle, WA. February 26, 2009.

5. “Network-based Mixture Models for Genomic Discovery” Division of Biostatistics seminar

series, University of Texas School of Public Health. Houston, TX. March 6, 2009.

6. “Statistical Methods for Systems Biology and Network Analysis” Human Genetics Center

seminar series, University of Texas School of Public Health, Houston, TX. March 29, 2010.

7. “Bayesian Joint Modeling of Multiple Gene Networks and Diverse Genomic Data to Identify

Target Genes a Transcription Factor” The Joint Statistical Meetings (JSM) 2010, Vancouver,

BC, Canada. July 31-August 5, 2010.

8. “Bayesian Joint Modeling of Multiple Gene Networks and Diverse Genomic Data” Division

of Quantitative Sciences seminar series, The University of Texas MD Anderson Cancer

Center, Houston, TX. September 22, 2010.

9. “Network-Based Bayesian Variable Selection Approach to Genome-Wide Association

Studies Data” SRCOS (Southern Regional Council on Statistics) Summer Research

Conference, McCormick, SC. June 7, 2011

10. “Network-based Bayesian Variable Selection Approach to Genome-wide Association Studies

Data” The Joint Statistical Meetings (JSM) 2011, Miami, FL. July 31-August 4, 2011.

11. “Network-Based Bayesian Variable Selection Approach to Genome-Wide Association

Studies Data” Department of Statistics seminar series, Texas A&M University (TAMU),

College Station. November 10, 2011.

12. “Bayesian Joint Modeling of Multiple Gene Networks and Diverse Genomic Data” Division

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of Biostatistics seminar series, University of Texas School of Public Health. Houston, TX.

March 20, 2012.

13. “Statistical methods for genome-wide evaluation of gene expression regulation mechanisms

using TCGA data” The Joint Statistical Meetings (JSM) 2012, San Diego, CA. July

28-August 2, 2012.

14. “Some New Statistical Methods for Detecting Gene by Environment Interactions” Human

Genetics Center seminar series, University of Texas School of Public Health, Houston, TX.

November 26, 2012.

15. “A Versatile Omnibus Test for Detecting Mean and Variance Heterogeneity for Quantitative

Traits”- invited session on “Statistical Methods in Dissecting Complex Traits”. ICSA

Applied Statistics Symposium/ISBS International Symposium on Biopharmaceutical

Statistics Joint Meeting, Bethesda, MD. June 9-12, 2013.

16. “Paradigm of genetic risk prediction: variable selection or mixed model” The Joint Statistical

Meetings (JSM) 2013, Montreal, Quebec, Canada. August 3-8, 2013.

17. “Functional Data Analysis Approach to Detecting Gene-Environment Interactions” Division

of Biostatistics seminar series, University of Texas School of Public Health. Houston, TX.

October 18, 2013.

18. “Novel Statistical Method for Detecting Gene by Longitudinal Environmental Exposure

Interaction with Application to Pancreatic Center” NIH National Cancer Institute (NCI)

Division of Cancer Control and Populations Sciences 2014 New Grantee Workshop.

Rockville, MD. January 6-7, 2014.

19. “Novel Statistical Methods for Gene-Environment Interactions with Application to

Pancreatic Center” (Invited Lecture) Pancreatic Cancer Case Control Consortium (PanC4)

Investigator Meeting, Johns Hopkins University, Baltimore, MD. March 20, 2014.


Pancreatic Center” Division of Biostatistics seminar series, Department of Clinical Sciences,

University of Texas Southwestern Medical Center, Dallas, TX. April 17, 2014.


Pancreatic Center” Statistics Colloquium, Department of Mathematical Sciences, University

of Texas at Dallas, TX. April 18, 2014.

22. Discussant in the session “Recent advances in Big Data analysis using cloud computing”

(sponsored by the ASA Biometrics Section) The Joint Statistical Meetings (JSM) 2014,

Boston, MA, August 2 - 7, 2014.

23. “Functional Logistic Regression Approach to Detecting Gene by Longitudinal

Environmental Exposure Interaction” Department of Statistical Science seminar series,

Southern Methodist University (SMU), Dallas, TX, September 19th, 2014.

24. “Using longitudinal exposures and phenotypes in GxE studies” Invited speaker at NIH

workshop “Continuing Challenges and New Opportunities for Gene-Environment Interaction

Studies of Complex Diseases”, San Diego, CA, October 17-18, 2014.

25. “Testing for polygenic effects in genome-wide association studies: a case study of Big Data

problem in genetics” Department of Biostatistics seminar series, University of Texas School

of Public Health. Houston, TX. February 6th, 2015.

26. “Novel statistical methods for detecting gene-environment interactions” Dartmouth College,

Hanover, NH, March 9th, 2015.

27. “Novel statistical methods for detecting gene-environment interactions” Department of

Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, March

23rd, 2015.

28. “Functional data analysis approaches to detecting gene-environment interactions” The Joint

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Statistical Meetings (JSM) 2015, Seattle, WA, August 9 - 13, 2015.

29. “Leveraging longitudinal and biological information in genetic epidemiology research”

Human Genetics Center seminar series, University of Texas School of Public Health,

Houston, TX. October 26, 2015.

30. “Functional data analysis approaches to causal inference in observational studies” Statistics

Seminar, University of Houston, Houston, Texas. November 6, 2015.

31. “Statistical methods for leveraging longitudinal data in genetic epidemiology research”

Department of Biostatistics, University of Michigan, Ann Arbor, MI. December 9th, 2015.

Contributed Presentations

32. “Incorporating gene functions into regression analysis of DNA-protein binding data and

gene expression data to construct transcriptional networks”. The International Biometric

Society Eastern North American Region (ENAR) 2007 Spring Meeting, Atlanta, GA. March

11-14, 2007.

33. “Incorporating gene networks into statistical tests for genomic data via a spatially correlated

mixture model”. The International Biometric Society Eastern North American Region

(ENAR) 2008 Spring Meeting, Arlington, VA. March 16-19, 2008.

34. “Incorporating gene networks into statistical tests for genomic data”. The Joint Statistical

Meetings (JSM) 2008, Denver, CO. August 3-7, 2008.

35. “Network-based genomic discovery: application and comparison of Markov random field

models”. (Distinguished Student Paper Award) The International Biometric Society Eastern

North American Region (ENAR) 2009 Spring Meeting, San Antonio, TX. March 15-18,

2009.

36. “Bayesian Joint Modeling of Multiple Gene Networks and Diverse Genomic Data to Identify

Target Genes a Transcription Factor” The International Biometric Society Eastern North

American Region (ENAR) 2010 Spring Meeting, New Orleans, LA. March 21-24, 2010.

37. “Bayesian Joint Modeling of Multiple Gene Networks and Diverse Genomic Data” The 4th

International IMS (International Institute of Mathematical Statistics) and ISBA

(International Society for Bayesian Analysis) Joint Meeting, Park City, Utah. January 5-7,

2011.

38. “Comparison of functional prediction methods for nonsynonymous SNPs in exome

sequencing-based study of Mendelian diseases” The 12th International Congress of

Human Genetics, Montreal, Quebec, Canada. October 11-15, 2011.

39. “Insights into pancreatic cancer etiology from pathway analysis of genome-wide association

study data” The American Society of Human Genetics (ASHG) 2012 Annual Meeting, San

Francisco, CA. November 6-10, 2012.

40. “A versatile omnibus test for detecting mean and variance heterogeneity for quantitative

traits” The International Biometric Society Eastern North American Region (ENAR) 2014

Spring Meeting, Baltimore, MD. March 16-19, 2014.

41. “A novel functional data analysis approach to detecting gene by longitudinal environmental

exposure interaction” WNAR/IMS Conference, Honolulu, HI. June 15-19, 2014.

42. “A novel functional data analysis approach to detecting gene by longitudinal environmental

exposure interaction” International Genetic Epidemiology Society (IGES) Annual Meeting,

Vienna, Austria. August 28-30, 2014.

SELECTED CONFERENCE CONTRIBUTIONS

1. Hebbel, R., Wei, P., Jiang, A., Hillery, C., Scott, J.P., Nelson, S.C., Enenstein, J., Milbauer,

L., Bodempudi, V., Pan, W., Hirsch, B., Topper, J.N., and Yang, R.B. (2007) Genetic

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Influence of the Systems Biology of Sickle Stroke Risk Detected by Endothelial Gene

Expression. The American Society of Hematology (ASH) Annual Meeting Abstracts 2007,

Blood 110(11): Abstract 427.

2. Mahmud, M.A., Wang, J., Wei, P., Thomas, M.S., Belcher, J.D., Vercellotti, G.M., and

Slungaard, A. (2007) The Major Phagocyte Peroxidase-Derived Oxidant, HOSCN

(Hypothiocyanous Acid), Induces Proinflammatory and Cytoprotective Gene Expression in

Endothelium: A Mechanism for Microlocalized Regulation of Inflammation. The American

Society of Hematology (ASH) Annual Meeting Abstracts 2007, Blood 110(11): Abstract

3295.

ACADEMIC SERVICE

Intra-Institutional Service

2011-present Biostatistics Department Representative on the UTSPH Faculty Council

2015-present Member on Faculty Diversity Subcommittee, UTSPH

2013-2015 Member and Chair Search Committee for Biostatistics Faculty in Big Data

2011-present Member on Biostatistics PhD Preliminary Exam Committee, UTSPH

2011 Spring Organizer of the Biostatistics seminar series, UTSPH

2010 Internal Grant Peer Review Panelist University of Texas School of Nursing at

Houston

2006-2007 Student Representative Biostatistics Faculty Meeting, University of Minnesota

Extramural Service

2015 External reviewer Promotion to Associate Professor with tenure, Department of

Mathematical Sciences, The University of Texas at Dallas.

2014 External Grant Reviewer Southern Methodist University, Dallas, TX

2010-2011 Member on University of Houston-Downtown (UHD) Scholars Academy K-20

Development Council

Service to the Profession

2016 Invited Session Organizer of “Statistical challenges and advances in the Precision

Medicine Initiative” (Invited session sponsored by the American Statistical Association

(ASA) Section on Statistics in Epidemiology) The Joint Statistical Meetings (JSM) 2016,

Chicago, IL, July 30-August 4, 2016 (upcoming).

2015 Session Organizer of “Recent advances in statistical methods for genetic study of

complex disease” (Topic-contributed session sponsored by the International Chinese

Statistical Association) The Joint Statistical Meetings (JSM) 2015, Seattle, WA, August 8-13,

2015.

2014 Session Chair of “Methods for statistical genetics” The International Biometric Society

Eastern North American Region (ENAR) 2014 Spring Meeting, Baltimore, MD. March

16-19, 2014.

2014 Session Chair of “Frontiers in statistical genetics for complex trait association” The

International Biometric Society Eastern North American Region (ENAR) 2014 Spring

Meeting, Baltimore, MD. March 16-19, 2014.

2014 Session Organizer of “Recent advances in Big Data analysis using cloud computing”

(Topic-contributed session sponsored by the ASA Biometrics Section) The Joint Statistical

Meetings (JSM) 2014, Boston, MA, August 2 - 7, 2014.

2013 Session Organizer of “Recent advances in disease risk prediction methods using

genetic and genomic data” (Topic-contributed session sponsored by ENAR) The Joint

Statistical Meetings (JSM) 2013, Montreal, Quebec, Canada, August 3 - 8, 2013.

11

2012 Member on International Chinese Statistical Association (ICSA) Applied Statistics

Symposium Student Paper Travel Award Committee

2012 Session Chair of “New trends in statistical analysis of biological networks” The

International Biometric Society Eastern North American Region (ENAR) 2012 Spring

Meeting, Washington, DC, April 1-4, 2012.

2012 Session Chair of “eQTL and Causal Analysis in Genomics” The Joint Statistical

Meetings (JSM) 2012, San Diego, CA, July 28-August 2, 2012.

2010 Session Chair of “Next generation sequencing and transcription factor in binding sites”

The International Biometric Society Eastern North American Region (ENAR) 2010 Spring

Meeting, New Orleans, LA.

Grant Reviewer

2015 Reviewer Cancer, Cardiovascular, and Sleep Epidemiology Panel B Study Section,

Center for Scientific Review, NIH

2015 Reviewer UK Medical Research Council (MRC)

2014 External Grant Reviewer Southern Methodist University, Dallas, TX

2010 Internal Grant Peer Review Panelist University of Texas School of Nursing at

Houston

Journal Referee

American Journal of Human Genetics (2013-)

Annals of Applied Statistics (2012-; served twice)

Annals of Human Genetics (2011-)

Biometrics (2010-; served twice)

Bioinformatics (2009- ; served 12 times)

Biostatistics (2014-)

BMC Bioinformatics (2010-)

BMC Genetics (2013-)

BMC Medical Genomics (2010-)

BMC Medical Informatics and Decision Making (2011-)

Briefings in Bioinformatics (2015-)

Cancer Prevention Research (2014-)

Carcinogenesis (2013-; served 3 times)

Computational Statistics and Data Analysis (2008-)

Computers in Biology and Medicine (2013-)

Genetic Epidemiology (2013-; served 4 times)

Heredity (2015-)

Human Genetics (2015-)

International Journal of Data Mining and Bioinformatics (2010-)

Journal of Biometrics and Biostatistics (2010-; served twice)

Journal of the American Medical Association (JAMA) (2008-; served 4 times)

Journal of the American Statistical Association (JASA) (2012-; served twice)

Journal of Medical Genetics (2011-)

Journal of Probability and Statistics (2014-)

Journal of Statistical Planning and Inference (2009-)

Model Assisted Statistics and Applications (2012-)

Nucleic Acids Research (2012-; twice)

PeerJ (2013-)

12

PLoS Computational Biology (2013-)

PLoS ONE (2010-)

Statistical Applications in Genetics and Molecular Biology (2011-)

Statistics and Computing (2013-)

Statistics in Biosciences (2011-; twice)

Statistics in Medicine (2011-; served twice)

TEACHING

University of Texas School of Public Health

Fall 2015 Course: PH1980 - Introduction to Genomics and Bioinformatics

Role: Course Co-instructor (15% effort)

Credits: 3 Enrollment: 16

Spring 2015 Course: PH1911-Theory of Biostatistics II (Statistical Inference)

Role: Course Instructor


Course Evaluation: 4.9/5




















Spring 2012 Course: PH1998 – Intro to Computational Systems Biology

Role: Course Instructor (25% effort)


Course Evaluation: 5/5

Fall 2011 Course: PH1998 – Resampling and Nonparametric Regression

Role: Course Instructor (newly developed course)


Course Evaluation: 5/5





Spring 2011 Course: PH1998-500-Current Issues in Biostatistics

13








University of Minnesota, School of Public Health

Spring 2007 Course: Statistical Learning and Data Mining

Role: Teaching Assistant

Fall 2005 Course: Statistics for Human Genetics and Molecular Biology


Fall 2004 & Summer 2005

Course: Biostatistical Methods I


STUDENT ADVISING AND COMMITTEE MEMBER

University of Texas School of Public Health

Students who have graduated

Student Name Degree Program Duration Role

Ying Wang MS in Biostatistics 2009-2011 Thesis advisor

(Current Position: Research Bioanalyst, University of Texas MD Anderson Cancer Center,

Department of Bioinformatics and Computational Biology)

Wafa F. Taiym MPH in

Epidemiology

2010-2011 Thesis committee

member

Hongwei Tang PhD in Epidemiology 2010-2012 Dissertation committee

member

(Current Position: Postdoctoral Fellow, The University of Texas MD Anderson Cancer

Center)

Henry Xingzhi Song MS in Biostatistics Summer 2010-Fall

2012

Thesis advisor

(Current Position: Institute Research Scientist, The University of Texas MD Anderson Cancer

Center, Applied Cancer Science Institute)

Hong Zhang PhD in Biostatistics 2011-2013 Dissertation committee

chair

(Current Position: The University of Texas MD Anderson Cancer Center)

Liang Chen MS in Biostatistics 2010-2013 Academic & Thesis

advisor

Bing Yu PhD in Epidemiology 2011-2013 Dissertation committee

member

(Current Position: Assistant Professor, Department of Epidemiology, Human Genetics, and

Environmental Science, The University of Texas Health Science Center at Houston)

Weihe Zhou MS in Biostatistics 2012-2013 Academic advisor

Saroochi Agarwal PhD in Epidemiology Fall 2012-

Fall 2013

Advisory committee

member

Jing Zhang MPH in Biostatistics 2012-2013 Academic advisor

Junsheng Ma PhD in Biostatistics Spring 2010- Academic advisor

14

Fall 2012

(Current Position: Postdoctoral Fellow, Department of Biostatistics, The University of Texas

MD Anderson Cancer Center)

Min Qiao MS in Biostatistics Fall 2011-Fall

2013

Academic advisor

(Current Position: PhD student, Division of Biostatistics, University of Texas School of

Public Health)

Zheng Wang PhD in Health Policy Spring 2012 -

Spring 2014

Dissertation committee

member

Getie Abeje Zewdie PhD in Biostatistics Fall 2010-

Spring 2014

Academic advisor &


member

Ning Shang PhD in Health

Informatics

Summer 2012-

Fall 2014


member

(Current Position: Postdoctoral Fellow, Columbia University)

Melissa Richard PhD in Epidemiology Summer 2013-

Summer 2014


member

(Current Position: Postdoctoral Fellow, Institute of Molecular Medicine, University of Texas

Health Science Center at Houston)

Nainan Hei MS in Biostatistics Fall 2011-Spring

2014

Academic advisor

Ping Chen MS in Biostatistics Fall 2012-Summer

2014

Academic advisor

John Teke MS in Biostatistics Fall 2012-Summer

2014

Thesis committee

member

Jialing Zhu MS in Biostatistics Fall 2011-

Summer 2014

Academic advisor

E Lin PhD in Biostatistics Fall 2012-

Fall 2014


chair

Caimiao Wei PhD in Biostatistics Fall 2011-

Spring 2015


Chair

Taebeom Kim PhD in Biostatistics Summer 2012-

Fall 2015

Dissertation advisor

(Current Position: Research Statistical Analyst, The University of Texas MD Anderson

Cancer Center, Department of Bioinformatics and Computational Biology)

Yining Du PhD in Biostatistics Spring 2011-

Fall 2015

Academic advisor &


member

Yaping Wang PhD in Biostatistics Spring 2014-

Fall 2015


member

Anqi Jin PhD in Epidemiology Fall 2013-

Fall 2014


member

Khanh Vu PhD in Epidemiology Fall 2013-

Spring 2015


member

Jie Yang MS in Epidemiology Fall 2014-

Spring 2015

Thesis committee

member

Mohammad Lutfur PhD in Biostatistics Fall 2010- Academic advisor &

15

Rahman Spring 2015 Dissertation committee

member

Dung-Yang Lee PhD in Biostatistics Fall 2012-

Spring 2015


member

Dung-Yang Lee PhD in Biostatistics Fall 2012-

Spring 2015


member

Ying Cao PhD in Biostatistics Fall 2013-

Summer 2015


(Current Position: Data Scientist, JPMorgan Chase & Co.)

Shabnam Azadeh PhD in Biostatistics Spring 2014-

Fall 2015


chair

Ying Cao PhD in Biostatistics Fall 2013-

Summer 2015


Li-An Lin PhD in Biostatistics Fall 2011-

Fall 2015

Academic advisor &


member

Yang Yang PhD in Biostatistics Spring 2013-

Fall 2015


(Current Position: Data Scientist, Philips Healthcare)

Jia Sun PhD in Biostatistics Summer 2013-

Fall 2015


member

Xiaoqi Li PhD in Biostatistics Fall 2010-

Fall 2015

Academic advisor &


member

Current Students

Student Name Degree Program Duration Role

Yue-Ming Chen PhD in Biostatistics Fall 2012- Dissertation advisor

(Passed proposal

defense in September

2014; Expected to

graduate in Fall 2015)

Yiding Ma PhD in Biostatistics Fall 2013- Academic advisor &


Tianzhong Yang PhD in Biostatistics Summer 2014- Dissertation advisor

Jing Huang PhD in Biostatistics Spring 2012- Academic advisor &


member; passed

proposal defense in

Summer, 2015

Jessica Sun MS in Biostatistics Summer 2013- Thesis committee

member

Qianghua Xia MS in Biostatistics Fall 2013- Academic advisor

Jihye Kim PhD in Epidemiology Summer 2012- Dissertation committee

member; passed

proposal defense in

January 2015

16

PROFESSIONAL MEMBERSHIP

Member, American Statistical Association (2004 - )

Member, Eastern North American Region (ENAR) / International Biometric Society (2007- )

Member, International Chinese Statistical Association (2011-)

Member, American Society of Human Genetics (2011-)

Member, International Genetic Epidemiology Society (2010-)

RESEARCH INTERESTS

Statistical Genetics and Genomics: gene-environment interaction; risk prediction model;

next-generation sequencing data; SNP-based and sequencing-based genetic association study

of complex disease; rare variants; Mendelian randomization analysis; systems biology;

integrative analysis of genomic and genetic data including gene networks/pathways, gene

expression, ChIP-seq, DNA sequence, and SNP arrays

Bayesian Methods in bioinformatics and genetics

Mixture Models: hidden Markov chain/random field models

Statistical Learning Methods and Applications

Last updated: December 7th, 2015

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Peng Wei - University of Texas School of Public Health

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