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Petiveria alliacea L. Extract for the Treatment of
Gastroesophageal Reflux Disease
Edwin J. Alvarado
Petiveria alliacea L.
Petiveria alliacea L., also known as Anamú or garlic weed, is a very influential plant in traditional medicine.
Proved to possess antibacterial1 and analgesic2 properties, among others.
Both contribute to the plant’s reputation for calming GERD symptoms.
Question/Problem
Can the extract from the Petiveria alliacea L. affect the stomach’s pH or, more ideally, the stomach’s acid irrigation?
Hypothesis
If the contents of the stomach are irrigated with the plant’s extract, the pH levels of the acid will increase, inhibiting the stomach’s acid irrigation over a long term exposition, sparing damage to the organs involved.
Chemical Experiment
Prepare a solution of HCl, KCl and NaCl, among others, add consecutive doses of extract and record pH.
To determine if extract acts as a buffer solution.
If true, determine buffer region.
In Vivo Experiment
Organism: Mice / Rats
Quantity: 20 per group (80 in total)
Variables: Presence of extract in ingestion
Presence of acid promoters
Prowess over time
Period: 4 weeks
Experimental Groups
Group A
P. alliacea extract
No acid promoter foods
Group B
P. alliacea extract
Acid promoter foods
Group C
No P. alliacea extract
Acid promoter foods
Control Group
Group D (NEGATIVE CONTROL)
No P. alliacea extract
No acid promoter foods
Methodology
Strict, standardized diets, varying only aforementioned factors.
After each week, collect five specimens from each group and extract stomach contents.
Analyze pH, acid concentration, gastric component concentration.
Interpret results.
Objectives
To determine if the extract “neutralizes” the stomach’s pH and in what capacity.
To determine if the extract affects the stomach’s acid irrigation and in what capacity.
To determine efficiency, if any, in abnormal stomach conditions.
To determine the efficiency, if any, of short term treatment versus long term.
Goal
Provide those afflicted with GERD an alternative treatment that both relieves pain and controls the disease
References
1. Kim S, Kubic R, Musah RA. Antibacterial and antifungal activity of sulfur-containing compounds from Petiveria Alliacea L. 2005. Available from: http://www.sciencedirect.com. Accessed: 2012 June 21.
2. Lopes-Martins RAB, Pegoraro DH, Woisky R, Penna SC, Sertié JAA. The anti-Inflammatory and analgesic effects of a crude extract of Petiveria Alliacea L. (Phytolaccaceae). 2004. Available from: http://www.sciencedirect.com. Accessed: 2012 June 21.
Thank you all for your time and consideration.
Are there any questions, comments or suggestions?