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10/10/18 1 Physical Cell Biology Lecture 14:DNA and random walks DNA: Phillips, Chapter 8,, Pollard chapter 7-9 Levels of Abstraction Microtubule DNA Polyethylene
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Physical Cell BiologyLecture 14:DNA and random walks
DNA: Phillips, Chapter 8,, Pollard chapter 7-9
Levels of AbstractionMicrotubuleDNA
Polyethylene
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Molecules as chains of small units
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Polymer configuration as a random walk
Distribution of End to End Distances
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Radii of Gyration for Different Chromosomes
Persistence Length
Figure from : Liverpool, T.B., “Active gels: where polymer physics meets cytoskeletal dynamics” Philosophical Transactions of the Royal Society – A, 364(1849), 2006, p. 3335-3355
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DNA and persistence length scales
Single Molecule Mechanics
AFM
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Force extension experiments
Optical trap/tweezers
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Magnetic tweezers
Pipette based force measurements
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