PICOPLUS - drshumailakhan.com€¦ · TRT (THERMAL RELAXATION TIME) Time that takes for an object...

PICOPLUS

Product Management

Marketing Department

Power and Versatility for Advanced Treatment and Mastery Over Difficult Cases

CURRENT TREATMENTS

Unwanted Tattoo & Benign pigmented Lesions

What were the laser treatment choices so far?

For the past 20 years, Q-switched lasers with nanosecond pulse duration have been available:

• Q-switched Nd:YAG (1064 nm & 532 nm) • Q-switched Alexandrite (755 nm) • Q-switched Ruby (694 nm)

WHAT LIMIT EFFICACY OF CURRENT TXTS?

Epidermal Pigmented Lesions

• Color density - sometimes too light • Precise setting - limited fluence settings • Side effects - high risk for PIH

Dermal Pigmented Lesions

• Depth of penetration - deep • Lack of power - less clearance • Thermal damage - nanosecond, truly selective? • Sessions - requires many sessions • Pain - painful even with anesthetic creams • Side effects - recalcitrant, recurrence, hyper- and hypo-,

mottled hyperpigmentation

WHAT LIMIT EFFICACY OF CURRENT TXTS?

Tattoo Removal

• Colors - not black always

• Particle size - small to large conglomerations

• Ink composition - various, unknown, unidentified

• Location / Depth - various, shallow, deep

• Efficacy - not always 100 %

• Sessions - requires many sessions

• Side effects - scarring, PIH

TRT (THERMAL RELAXATION TIME)

Time that takes for an object to cool down to half of its increased temperature gap from its initial temperature.

It is a rule that a smaller object cools faster than a larger object of the same material and shape which means that the smaller target has a shorter thermal relaxation time.

SELECTIVE PHOTOTHERMOLYSIS

“Selective absorption of light pulses by pigmented target (specific chromopore) such as blood vessels, pigmented cells, and tattoo ink particles to achieve selective thermally mediated injury” RR Anderson et al, Science 220:524, 1983


Wavelength that is absorbed by the target. Pulse Width that is less than or equal to cooling: Thermal Relaxation Time (TRT). Energy that will enable to target to reach the damaging temperature.


Thermal diffusion

Non-Selective Selective

1. Wavelength

2. Pulse width

3. Energy


Short-pulsed Laser

Melanin or ink particles Explosion Absorption and

drainage by human immune system

Macrophage


Dendritic Processes

[Before Laser Toning]

[After Laser Toning]

Source: Journal of Electron Microscopy, 2011; 60: 11–18

A low fluence Q-switched Nd:YAG laser modifies the 3D structure of melanocyte and ultrastructure of melanosome by subcellular-selective photothermolysis

CASE DISCUSSION

?

CASE DISCUSSION

NEXT TO SELECTIVE PHOTOTHERMOLYSIS

Laser

Photoacoustic Waves

Laser Pulse Absorption Thermal

Expansion Acoustic Waves

Photomechanical (Photoacoustic)

• Stress Relaxation Time (SRT)



Source: Physical characteristics and biological effects of laser-induced stress waves -A. G. Doukas Ultrasound in Med. & Biol., Vol. 22, No. 2, pp. 151-164. 1996



Ultrafast time-resolved imaging of stress transient and cavitation from short pulsed laser irradiated melanin particles Charles P. Lin and Michael W. Kelly, Weliman Laboratories of Photomedicine, PIE Vol. 2391


70 ns, Er:YAG, 700 um, 2.8 J/cm2, Water ablation, Shock wave picture (Schlieren photographs )


200 us, Er:YAG, 2.3 mm, 20 J/cm2, Human skin, Shock wave picture (Schlieren photographs )

After 22.4 us After 40 us


Stress confinement time

= D(Target Size) / Speed of sound in medium

If the laser pulse duration < SRT

Increased Photomechanical effect!


PHOTOTHERMAL PHOTOMECHANICAL (PHOTOACOUSTIC)

Nanosecond Pulse Duration (ns) Picosecond Pulse Duration (ps)

Thermal Relaxation Time (TRT) Stress Relaxation Time (SRT)

Therefore, we need shorter picosecond pulse duration.

DIFFERENT PULSE DURATIONS

• 1 second (s) = 1/1 (s) = 1 (s)

• 1 millisecond (ms) = 1/1,000 (s) = 10-3 (s)

• 1 microsecond (us) = 1/1,000,000 (s) = 10-6 (s)

• 1 nanosecond (ns) = 1/1,000,000,000 (s) = 10-9 (s)

• 1 picosecond (ps) = 1/1,000,000,000,000 (s) = 10-12 (s)

• 1 femtosecond (fs) = 1/1,000,000,000,000,000 (s) = 10-15 (s) • 1 attosecond (as) = 1/1,000,000,000,000,000,000 (s) = 10-18 (s)

NANO VS. PICO

Nanosecond (10-9 second) vs. Picosecond (10-12 second)

Peak Power

Time

Peak Power (W) = Energy (J) / Pulse Duration (s)

5 nanosecond

550 picosecond

NANO VS. PICO

Nanosecond (10-9 second) Picosecond (10-12 second)

Traditional Lasers PICOPLUS

NANO VS. PICO

Nanosecond (10-9 second) Picosecond (10-12 second)

Traditional Lasers PICOPLUS

No further improvement

Requires much less sessions

Requires multiples sessions sometimes over a year

CURRENT QS LASERS

PICOSECOND LASERS

Completely removed

NANO VS. PICO

No further improvement

Requires much less sessions

Requires multiples sessions sometimes over a year

CURRENT QS LASERS

PICOSECOND LASERS

Completely removed

NANO VS. PICO

LITERATURE REVIEWS

• Prinz et al. (2004) studied 74 patients.

• Treated with 755, 1064, 532 nm

• 14 pts (19 %): > 95 % lightening • 23 pts (31 %): 76 – 95 % lightening • 21 pts (28 %): 51 – 75 % lightening • 16 pts (22 %): < 50 % lightening

• 1 to 10 sessions during 1 to 6 months

Click here for original paper

Source: British Journal of Dermatology 2004; 150: 245–251.

Prinz et al. (2004).pdf

LITERATURE REVIEWS

• Bencini et. al. (2012) studied 352

patients. • Treated with QS 755, 1064, 532

nm

• 47.2 % of pts reached successful clearance after 10 sessions

• 74.8 % of pts reached successful clearance after 15 sessions


Source: Arch Dermatol/Vol 145 (no.12), Dec 2012

Bencini et. al. (2012) .pdf

LITERATURE REVIEWS


• Herd et. al. (1999) studied on 6 tattooed guinea pigs.

• Ti:Sapphire (experimental laboratory setting) 795 nm, 500 ps

• Alexandrite 752 nm (candela), 50 ns

• 6 tattoos per pig (tattooed five months ago) [3 split-tattoos] Treated by T:Sapphire and Alexandrite at 75 mJ [3 tattoos] Untreated as control

• Biopsy at baseline, 11 and 16 weeks after single

session

• Greater clearance on Ti:Sapphire side

Source: Journal of the American Academy of Dermatology, April 1999

Herd et. al. (1999).pdf

LITERATURE REVIEWS

• Picosecond is more effective than nanosecond.

• Inertial confinement time for tattoo ink particle is 1 ns.


LITERATURE REVIEWS

PS PS PS PS

PS PS

• Ti:Sapphire side (500 ps) has better clearance.


LITERATURE REVIEWS

• Ross et. al. (1988) compared a 1064 nm picosecond laser to a 1064 nm nanosecond laser on 16 subjects.

• Experimental laboratory setting; [Split-tattoo part 1] 1064 nm (10 mJ), 1.4 mm, 0.65 J/cm2, 35 ps [Split-tattoo part 2] 1064 nm (10 mJ), 1.4 mm, 0.65 J/cm2, 10 ns [Split-tattoo part 3] 1064 nm (392 mJ), 2.5 mm, 8.0 J/cm2, 10 ns

• 4 treatments at 4 week intervals

• 12 pts (75 %) shows pico-side showed better

clearance. • However, nano in part3 was better. So need

high-energy picosecond.


Source: Arch Dermatology / Vol 134, Feb, 1998

Ross et. al. (1988) .pdf

LITERATURE REVIEWS

• Ave. tattoo particles is 40 nm. • TRT is assumed less than 1 ns.

• Thermal confinement is achieved with a 35 ps.

Source: Arch Dermatology / Vol 134, Feb, 1998 < 타투 입자 TEM 영상>

LITERATURE REVIEWS

• Pre: electron-dense • Post: mixture of electron-dense and

electron-lucent with lamellations • Pre: uniform • Post: enlarged “bubblelike”

particles mixed with apparently unaltered particles.


LITERATURE REVIEWS

• Conventional high-fluence ns shows better result than low-fluence ps, therefore need high-energy ps device.


LITERATURE REVIEWS

• Diameter of melanosome is 1 um. • TRT of melanosome is 50 to 500 ns.

• Diameter of tattoo is 40 nm.

Source: Atlas of Cosmetic Surgery, 2nd Edition

LITERATURE REVIEWS

• 1-um melanosome has TRT ranging from 0.5 to 1 us.

• 0.5-um melanosome has TRT of 0.25 us.

NANO VS. PICO

Courtesy of S.B. Cho, MD, South Korea, Comparison between nano- and pico-second on tissue phantom

Tissue Phantom Experiment Setting

Original tissue phantom

Injection of tattoo ink

Tissue phantom with tattoo ink

NANO VS. PICO


Laser Beam (1064 nm)

Tissue Phantom Experiment Setting

NANO VS. PICO


5 nanoseconds 750 picoseconds

4 mm, 4.8 J/cm2, 1 pass 4 mm, 4.8 J/cm2, 1 pass

Less tattoo particles are shattered.

More tattoo particles are shattered.

Horizontal View Horizontal View

NANO VS. PICO


5 ns, 7 mm, 1.5 J/cm2, 5 passes [Initial 5 passes]

750 ps, 7 mm, 1.5 J/cm2, 5 passes [Initial 5 passes]

No further break-ups of tattoo inks even after more shots.

Tattoo inks are broken up further.


5 ns, 7 mm, 1.5 J/cm2, 10 passes [Additional 5 passes]

750 ps, 7 mm, 1.5 J/cm2, 10 passes [Additional 5 passes]



NANO VS. PICO


However, we couldn’t see significant difference at low fluence such as 1.5 J/cm2. So decided to repeat at higher fluene setting (See next slide)

750 ps, 7 mm, 1.5 J/cm2, 5 passes [Initial 5 passes]

Tattoo inks are broken up further.

750 picoseconds

750 ps, 7 mm, 1.5 J/cm2, 10 passes [Additional 5 passes]

Horizontal View

Horizontal View

NANO VS. PICO


5 nanoseconds + 5 nanoseconds

5 nanoseconds + 750 picoseconds

5 ns, 4 mm, 4.8 J/cm2, 5 passes 5 ns, 4 mm, 4.8 J/cm2, 5 passes

5 ns, 4 mm, 4.8 J/cm2, 5 passes 750 ps, 4 mm, 4.8 J/cm2, 5 passes

Less tattoo particles are shattered.

Almost all tattoo particles are shattered.


NANO VS. PICO



5 ns, 4 mm, 4.8 J/cm2, 1 pass 750 ps, 4 mm, 4.8 J/cm2, 1 pass

Vertical View Vertical View

Videotaped by ultrahigh-speed digital camera (Phantom v2512 model)

HighSpeed-nanosec.mp4

HighSpeed-picosec.mp4

NANO VS. PICO



5 ns, 4 mm, 4.8 J/cm2, 1 pass 750 ps, 4 mm, 4.8 J/cm2, 1 pass


NANO VS. PICO

Na

no

se

co

nd

la

se

r

(4J/c

m2)

Pic

ose

co

nd

la

se

r

(2J/c

m2)

Nan

ose

con

d la

ser

(4

J/cm

2)

Pic

ose

con

d la

ser

(2J/

cm2)

Courtesy of K.H. Kim, PhD. South Korea, PoHang Univ. of Science and Technology

Before After

NANO VS. PICO


Nan

ose

con

d la

ser

(4

J/cm

2)

Pic

ose

con

d la

ser

(2J/

cm2)

Before After

NANO VS. PICO

Na

no

se

co

nd

la

se

r

(4J/c

m2)

Pic

ose

co

nd

la

se

r

(2J/c

m2)


[Picosecond, 0.5 J/cm2]

Day 2 Day 65

[Nanosecond, 1.0 J/cm2]

Day 2 Day 65

FEEDBACKS OF PS LASER USERS

•Better and fast results (less sessions)

•Better skin reaction

• Less pain and scarring

• Less downtime

• Less side effects

•Able to treat recalcitrant cases


Nanosecond laser Picosecond laser

5-10 ns : Q-Switch Nd:YAG 50-100 ns : Q-Switch Alexandrite 20-50 ns : Q-switch Ruby

750 ps : picosecond Alexandrite 350-750 ps : picosecond Nd:YAG

Photoacoustic effect : significant Photoacoustic effect : more significant

More thermal effect - heats transferred to pigment and surrounding tissues

Less thermal effect - less painful - less post treatment erythema

Weaker mechanical fragmentation - but, not insufficient to conventional use - needs more energy than pico laser

Stronger mechanical fragmentation - can treat with lower energy

Governed by thermal relaxation time Mainly governed by stress relaxation time (mechanical stress)


• Limitations on current 532 nm picosecond

• Fluence parameters are not reduced as 1:1 proportional to the decrease of pulse duration. (e.g. Fluence setting is usually 1/2 or 1/3 of the fluence setting in nano device.)

• Still require multiple wavelengths

LIMITATIONS ON CURRENT 532 NM PICOSECOND

PICOPLUS 532 nm, 2.3 mm

57 choices (w/ min. 0.02 interval)

0.24 J/cm2

(10 mJ) 7.2 J/cm2

(299 mJ)

Fluence Range (J/cm2)

0.50 1.50 2.50

0.60 1.60

0.70 1.70

0.80 1.80

0.90 1.90

1.00 2.00

1.10 2.10

1.20 2.20

1.30 2.30

1.40 2.40

Competitor 532 nm, 2.0 mm

21 choices (w/ min. 0.1 interval)

0.50 J/cm2

(16 mJ) 2.50 J/cm2

(79 mJ)

Fluence Range (J/cm2)

0.24 0.50 1.00 2.00 4.00 6.00

0.26 0.55 1.10 2.20 4.20 6.20

0.28 0.60 1.20 2.40 4.40 6.40

0.30 0.65 1.30 2.60 4.60 6.60

0.32 0.70 1.40 2.80 4.80 6.80

0.34 0.75 1.50 3.00 5.00 7.00

0.36 0.80 1.60 3.20 5.20 7.20

0.38 0.85 1.70 3.40 5.40

0.40 0.90 1.80 3.60 5.60

0.45 0.95 1.90 3.80 5.80

PICOPLUS SPOT SIZE (mm) 0.9 1.5 2.3 3.3 4.3 5.3 6.5 8.0 9.0 n/a

Competitor SPOT SIZE (mm) 1 2 3 4 5 6 7 8 9 10

PICOPLUS Max. Fluence (J/cm2) 45.00 17.00 7.20 3.40 2.00 1.30 0.90 0.60 0.45 n/a

PICOPLUS Min. Fluence (J/cm2) 1.60 0.60 0.24 0.12 0.07 0.05 0.03 0.02 0.02 n/a

Competitor Max. Fluence (J/cm2) n/a 6.25 2.80 1.60 1.00 0.72 0.52 0.40 0.32 0.25

Competitor Min. Fluence (J/cm2) n/a 3.25 1.40 0.80 0.50 0.36 0.26 0.20 0.16 0.13

LIMITATIONS ON CURRENT 532 NM PICOSECOND

TREATMENT PARAMETER CHANGE

Nanosecond (10-9 second)

Picosecond (10-12 second)

5 ns 750 ps 6.6 times decrease

1.2 J/cm2 0.6 J/cm2 2 times

decrease

Therefore, we need pico laser with high energy output!

WIDE-RANGE OF FLUENCE OPTIONS

Is high-powered laser only solution? Q) What about low-powered laser? Q) What about precise fluence setting?



1 mm 2 mm 3 mm 4 mm 5 mm 6 mm 7 mm 8 mm 9 mm 10 mm

100.00 24.00 11.00 6.40 4.00 2.80 2.00 1.60 1.20 1.00

6.40 1.60 0.70 0.40 0.26 0.18 0.13 0.10 0.08 0.07

n/a 12.50 5.50 3.20 2.00 1.40 1.00 0.80 0.65 0.50

n/a 5.50 2.50 1.40 0.90 0.60 0.45 0.35 0.25 0.20

PICOPLUS Max. Fluence (J/cm2)

PICOPLUS Min. Fluence (J/cm2)

Competitor Max. Fluence (J/cm2)

Competitor Min. Fluence (J/cm2)

0.01

0.10

1.00

10.00

100.00

1 2 3 4 5 6 7 8 9 10

PICOPLUS Max. Fluence (J/cm2)

PICOPLUS Min. Fluence (J/cm2)


450 ps, 400 mJ vs. 550 ps, 800 mJ

• Peak Power = 0.89 Gw • Fluence @ 8 mm = 0.8 J/cm2

• Peak Power = 1.45 Gw • Fluence @ 8 mm = 1.6 J/cm2

8 mm spot 8 mm spot

STILL REQUIRES MULTIPLE WAVELENGTHS

STILL REQUIRES MULTIPLE WAVELENGTHS

532 nm

1064 nm (and all)

Two-wavelengths only (1064, 532 nm)

Four-wavelengths (1064, 532, 595, 660 nm)

595 nm

660 nm

532 nm

1064 nm (and all)

NANO VS. PICO

Other Picosecond Lasers PICOPLUS

NANO VS. PICO

Other Picosecond Lasers PICOPLUS

Shorter pulse duration

High & Low Energy

Multiple wavelengths

SOLUTIONS

Close to QS More than two Picosecond

SPECIFICATION

• Nd:YAG

• 1064, 532, 595, 660 nm

• 550 ps & 2 ns & P-PTP

• Max. 800 mJ

• Max. 10 mm

• Max. 10 Hz

SPECIFICATION

DESCRIPTION SPECIFICATION Medium Nd:YAG

Wavelength/ Pulse Width/ Max. Energy

1064 nm 800 mJ @ 550 ps

800 mJ @ 2 ns

1064 nm P-PTP 800 mJ @ 550 ps + 550 ps

532 nm 300 mJ @ 550 ps

300 mJ @ 2 ns

595 nm 110 mJ @ 550 ps

110 mJ @ 2 ns

660 nm 90 mJ @ 550 ps

90 mJ @ 2 ns

Handpiece

Zoom (1064 nm, 532 nm)

1064 nm: 1, 2, 3, 4, 5, 6 mm 532 nm: 0.9, 1.5, 2.3, 3.3, 4.3, 5.3 mm

Pico Toning Collimated (1064 nm, 532 nm)

1064 nm: 6, 7, 8, 9, 10 mm 532 nm: 4.3, 5.3, 6.5, 8.0, 9.0 mm

Gold Toning+ (595 nm)

2, 5 mm

RuVY Touch+ (660 nm)

2, 3 mm

Focused Dots (1064 nm)

7.4 mm x 7.4 mm

Pulse Rate

1064 nm Max. 10 Hz

532 nm Max. 10 Hz (≤ 40 mJ), Max. 5 Hz (>40 mJ)

595 nm Max. 5 Hz

660 nm Max. 2 Hz

FEATURES Articulated Arm

Foot Switch

Built-in storage (for handpieces and goggles)

GUI Touch Screen

Power Switch

Weight (kg): 142 Dimension (mm): 483(W) X 1078(L) X 1119(H)

Calibration Port

Handpiece

Emergency Switch

FEATURES – GUI

FEATURES

• Zoom Handpiece

• Pico Toning Collimated Handpiece

• Gold Toning+ Handpiece

• RuVY Touch+ Handpiece

• Focused Dots Handpiece

FEATURES

Zoom Handpiece 1, 2, 3, 4, 5, 6 mm @ 1064 nm 0.9, 1.5, 2.3, 3.3, 4.3, 5.3 mm @ 532 nm Auto-detection: detects both handpiece and spot

sizes

Clinical Uses : used for below indications at 1064 nm 1. Black and dark tattoos 2. Dermal pigmented lesions (Nevus of

Ota, ABNOM, etc.)

Clinical Uses : used for below indications at 532 nm 1. Red tattoos 2. Epidermal pigmented lesions

(freckles, SK, etc.)

FEATURES

Pico Toning Collimated Handpiece 6, 7, 8, 9, 10 mm @ 1064 nm 4.3, 5.3, 6.5, 8.0, 9.0 mm @ 532 nm Auto-detection: detects both handpiece and spot

sizes

Clinical Uses : used for below indications at 1064 nm 1. Black and dark tattoos 2. Dermal pigmented lesions

(melasma, Nevus of Ota, ABNOM, etc.)

Clinical Uses : used for below indications at 532 nm 1. Red tattoos 2. Epidermal pigmented lesions


FEATURES

Gold Toning+ Handpiece 2, 5 mm @ 595 nm Separate tips for each spot size Auto-detection: detects handpiece only (spot sizes

are manually selected)

Clinical Uses : used for below indications at 595 nm 1. Colored Tattoos (sky blue) 2. Post-acne erythema, inflammatory

acne, facial flushing, rosacea

FEATURES

RuVY Touch+ Handpiece 2, 3 mm @ 660 nm Auto-detection: detects handpiece only (spot sizes

are manually selected)

Clinical Uses : used for below indications at 660 nm 1. Colored Tattoos (green) 2. Epidermal pigmented lesions


FEATURES

1064 nm Focused Dots Handpiece 7.4 mm X 7.4 mm @1064 nm 81 micro-focused spots (diameter of 100 um each) Auto-detection: detects handpiece (spot size is

fixed)

Clinical Uses : used for below indications at 1064 nm 1. Final Resurfacing 2. Skin rejuvenation (Cold Rejuvenation) 3. Fine wrinkles 4. Scars

FEATURES

Highly-focused photoacoustic waves creates focused layers creating LIOBs (Laser Induced Optical Breakdowns) in tissue phantom.

Vertical View

FEATURES


750 ps, 7.4 mm, 1.1 J/cm2 (600 mJ),

1 pass


COMPARISONS

Focused Dots Handpiece

Single pass Source: Lutronic R&D

COMPARISONS


Multi-passes Source: Lutronic R&D

COMPARISONS


Multi-passes Source: Lutronic R&D

FEATURES

Focus Toning

Baseline After 4th Tx

CLINICAL PHOTOS

Acne Scars (by Focus Toning)

Permitted for marketing use

Normal View

CLINICAL PHOTOS



Depression


CLINICAL PHOTOS



Wrinkles


CLINICAL PHOTOS



Melanin


CLINICAL PHOTOS



Hemoglobin


CLINICAL PHOTOS



Normal View


CLINICAL PHOTOS



Depression


CLINICAL PHOTOS



Wrinkles


CLINICAL PHOTOS



Melanin


CLINICAL PHOTOS



Hemoglobin


CLINICAL PHOTOS



Normal View

Baseline After 2nd Tx

CLINICAL PHOTOS



Depression


CLINICAL PHOTOS



Wrinkles


FEATURES

Precise Parameter (Fluence) Setting

Reason to have ‘jog & shuttle’

FEATURES

Aiming Beam

• Automatically adjusted according to spot sizes selected • Only works at 1064 nm and 532 nm

1 mm 6 mm 10 mm

FEATURES

Peak Power

Time

550 ps

800 mJ

Tissue Reaction

Time

PICO Mode

• single powerful picosecond pulse

FEATURES

NANO Mode

• Two consecutively delivered picosecond pulses, recognized by tissue as single 2-ns pulse.

Tissue Reaction

Time

Peak Power

Time

550 ps 550 ps

900 ps

800 mJ

400 mJ 400 mJ

FEATURES

2 ns in PICOPLUS vs 2 ns in Traditional Way

• Both create different tissue reactions.

Tissue Reaction

Time

Tissue Reaction

Time

VS.

2 ns in PICOPLUS 2 ns in Traditional Way

FEATURES

P-PTP Mode (Pico Pulse-to-Pulse Mode) • Two consecutively delivered picosecond pulses but with sufficient interval

time between pulses for tissue to cool, resulting in more mild tissue reaction while delivering the same amount of energy.

Peak Power

Time

550 ps 550 ps 90 µs interval

400 mJ 400 mJ 800 mJ

Tissue Reaction

Time

INDICATIONS

• Tattoo (inc. colored) • Melasma • PIH • Nevus of Ota • ABNOM • Lentigo • Freckles • Seborrheic Keratosis • Final Resurfacing • Skin Rejuvenation (Cold Rejuvenation) • Post-acne erythema • Inflammatory acne • Facial flushing • Rosacea

INDICATIONS

CLINICAL PHOTOS

Tattoo (Black) – Immediate Skin Reaction

Nanosecond

Picosecond


CLINICAL PHOTOS

Tattoo (Black)

Before

(not fresh)

After 1st session

Courtesy of G.S. Lee, MD, South Korea


CLINICAL PHOTOS

Tattoo (Black)

Before

(not fresh)



After 2nd session

CLINICAL PHOTOS

Tattoo (Black)

Before

(not fresh)



After 3rd session

CLINICAL PHOTOS

Tattoo (Black)

Before After 2 sessions



CLINICAL PHOTOS

Tattoo (Black)




CLINICAL PHOTOS

Tattoo (Red)


with 1064 nm (L) and 532 nm (R)



CLINICAL PHOTOS

Freckles

Before After 1 session

(with 532 nm) Courtesy of G.S. Lee, MD, South Korea


CLINICAL PHOTOS

Freckles

Before After 1 session

(with 532 nm) Courtesy of G.S. Lee, MD, South Korea


HIGHLIGHTS OF PICOPLUS (1)

• Four high-powered wavelengths

• Still with sufficient and stable high and low energy output

• Widely-ranged fluence

• Precisely controllable fluence (jog & shuttle)

• 5 Handpieces (including Focus Dots Handpiece) • Dual pulse duration: pico and nano

• Built-in storage

HIGHLIGHTS OF PICOPLUS (2)

• Clear resistant tattoos and recalcitrant pigmented lesions (e.g. Café-au-Lait, Nevus of Ota, ABNOM, Nevus Spilus, Blue Nevus, etc.)

• Reduces number of sessions for tattoos and pigmented lesions.

• Always better results than nano.

• Protects epidermis even at higher fluence parameters

• 532 nm at picosecond is good choice for epidermal pigmented lesions.

• Provides prices control especially at 532 nm

• Both hypo- and hyperpigmentation at nano. Only hyper-pigmentation at pico.

• Less post-treatment pain sensation and thermal accumulation

• 1064 Focused Dots HP for final resurfacing is good!

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