pistoiaalliance.org

Ramesh Durvasula, Ph.D.Communications Officer, Pistoia AllianceDirector, Chemistry Informatics, BMS

BioIT World 2010

The Pistoia Alliance

A Construct for Pre-competitive Collaboration and Open Innovation

Agenda

• Origins of Pistoia– History– Industry Drivers– Technology Trends

• Scope and Operations of Pistoia– Mission, Membership, Governance– Projects and Deliverables

• Discussion

Industry Driver: Externalization

DA

TA C

RO

BIO

CR

OC

HE

M C

RO

PHA

RM

ASelectivelyIntegrated

Model

Fully InternalModel

Cost pressures, disruptive technologies, and other forces often drive business processes to be externalized.

Emerging Net-centric PharmaProcesses

PHARMA1

CRO2

CRO1

CRO3

PHARMA2

PHARMA3

CRO4

Inconsistent Semantics degrade Effective Communication

A

B

C

The result from our proprietary assay is “B”

But we only record numbers in our assays!!

PHARMA

CRO

Image/quote from Abdul-Malik Shakir

Greater Challenge: Unknown Semantic Collisions

Revealing assumptions is an essential component of effective communication.

Opportunity: Changing Tech Landscape

More Robust Technologies• Web 2.0 / 3.0• Services-Oriented Architecture• Software-as-a-Service• Open Source Initiatives

More Robust External Content• Publicly available chem and bio sources• Richer literature content• Academic Sources of Tools and Data

The Path Forward:Standardize, Simplify, Centralize

• Standardize our interfaces and messages

• Simplify our cross-industry architectures and support models

• Centralize services to reap economies of scale and scope

Background—How it all started

• In Pistoia, Italy

• Meeting of GSK, AZ, Pfizer and Novartis—identified similar challenges and frustrations in discovery informatics

9

Pistoia Mission

• The Mission– Pistoia will standardize and streamline data

interchange in life science R&D.• The Method

– Precompetitive collaboration between life science, academia, and commercial partners.

• The Result– Standardization will drive down the cost of data

exchange, cloud computing, and process outsourcing.• The Benefit

– Informatics organizations can streamline commodity services, and focus investment on innovation in R&D.

Benefits of Pistoia

• R&D Organizations– Optimized investments

• e.g. reduction of redundant investments across industry– Increased agility to leverage global R&D

• Rapid integration, streamlined data interchange and analysis

• Informatics Solution Providers– New markets and business models– Reduced cost-of-entry to markets– Reduction of customized solutions, leading to

higher margins

Pistoia Membership

updated: April 2010

Pre-competitive Space in the Technology Lifecycle

Precompetitive SpaceOpportunities for Standards

Legacy

Commodity

Mainstream

Innovation

Experiment

Crossing the Chasm

• Pistoia is the BRIDGE to cross the chasm to a more agile pre-competitive environment

STANDARDIZE SIMPLIFY CENTRALIZE

PISTOIA MEMBERS SUPPLIERS

Learn from Other Industries

Transportation

Geospatial

Automotive

ClinicalRetail

Banking

Healthcare

16

Phase III

Scope of Pistoia Efforts

Phase ILead OptLead IDHit IDTarget ID

Which Target? Which Compound?Which Disease?What Biomarkers?

Disease AssociationBioprocess AssocDruggability‘On Target’ Safety RiskValidation ToolsCompetitive PositionVariant Selection…

DMPK Properties?BioAssay DevelopmentActivity-Dose studies?‘Off Target’ Safety Risk?Synthesis routes?Competitive Position?…

CD positioning?Safety Biomarkers?Efficacy Biomarkers?…

Genome/Genetic Data

Sequence Data

Expression Data

Genome/Genetic Data

Pathway Data

Patent Data

Pharmacology Data

Literature Data

Structural Data

Phase II

17

Pistoia Standards Process

Technical & Standards Teams

Governance & Strategy Board

Operational Team

Life ScienceCommunity

Governance & Operations

Software and Service Providers

Pharma/BioTech/Agro

Not for Profit (e.g. IMI, EBI)

propose,comment

publish

coordinate

Pistoia Working Groups

Current, Active Pistoia Projects

• Semantic Enrichment of Scientific Literature– An open knowledge brokering framework standard which will

reduce the costs of integration from disparate sources.

• Sequence Services– A standard service to provide access to public, private &

commercial data & tools, that will enable scientists to search, store & analyse all their sequence based data in a single web interface.

• ELN Query Service– A query service standard applicable for use with data types

commonly found in electronic lab notebooks

Assertion & Meta Data MgmtTransform / TranslateIntegrator

Service Layer

Corpus 1

ConsumerFirewall

SupplierFirewall

Proprietary Service Broker

MultipleConsumers

SESL: Biomedical Knowledge Service Framework

Db 2

Db 3

Db 4

Corpus 5

Std PublicVocabularies

KnowledgeApplications

TargetDossier

CompoundDossier

DiseaseDossier

ContentSuppliers

Effort required to fit DBs to service layer

BusinessRules

NetworkViz

OpenStds

Common Service Broker

A Production SESL Service

Broker Org #4Broker Org #3Broker Org #2

Corpus 1

ConsumerSide

SupplierSide

Db 2

Assertion & Meta Data Mgmt

Transform / Translate

Integrator

Service Layer Std PublicVocabularies

BusinessRules

Assertion & Meta Data Mgmt

Transform / Translate

Integrator

Service Layer Std PublicVocabularies

BusinessRules

Assertion & Meta Data Mgmt

Transform / Translate

Integrator

Service Layer Std PublicVocabularies

BusinessRules

Assertion & Meta Data Mgmt

Transform / Translate

Integrator

Service Layer Std PublicVocabularies

BusinessRules

Broker Org #1

Db 3

Corpus 4

Corpus 5

Db 6

Db 7

Corpus 8

Corpus 9

Db 10

Db 11

Corpus 12

Corpus 13

Db 14

Db 15

Corpus 16

Disease Dossier

License

Exemplar Application

SESL Mock Up Slide 1

Gene:

Disease: Relationship:

Constraint:

abcAnyDiabetesSpecies: AnyTissue: Any

abc1Gene R’ship Disease

Co-occursSpecies

Diabetes MusEvidencePaper UID:1234

abc1 Up-Reg Diabetes Homo ArrayExpress: XXXabc2 Co-occurs Diabetes Homoabc13 Co-occurs Diabetes Musabc7 Mutation Diabetes Rattusabc1 Co-occurs Diabetes Musabc1 Co-occurs Diabetes Homo

Paper UID:1344Paper UID:1314OMIMI: XXXPaper UID:45643Paper UID:2143

Export to Network View Pivot on Assertion

1234567

abc1 Co-occurs Diabetes Mus Paper UID:12048

SESL Mock Up Slide 2

abc1Gene R’ship Disease

Co-occursSpecies

Diabetes MusSupporting Evidence3

abc7 Mutation Diabetes Rattus 1

Export to Network View Return

1

abc1 Up-Reg Diabetes Homo 13abc1 Co-occurs Diabetes Homo 12

4

abc2 Co-occurs Diabetes Rattus 1abc13 Co-occurs Diabetes Mus 15

6

SESL Mock Up Slide 3

Current SESL Participants

AstraZeneca FundingGSK FundingRoche FundingPfizer FundingUnilever FTEsEuropean Bioinformatics Institute FTEs & HostingOxford University Press ContentNature Publishing Group ContentElsevier ContentRoyal Society of Chemistry Content

If you want to go fast, go alone. If you want to go far, go together.

www.pistoiaalliance.org

Backup Slides

Where We Are

Who we Are: Board of Directors

GSKAZNovartisPfizerLundbeckBMSRoche

AccelrysChemAxonSymyxCambridgeSoftInfosysThomson Reuters

Pistoia Membership Levels

• Core Member ($15,000)– Those organisations wishing to strongly influence the strategy &

direction of the Alliance– Have a majority on the Governance & Strategy Board– Pharma, Life Science, Chemicals/Biologics primary business focus

• Participating Member ($10,000)– Those wishing to influence the technical outcomes– Access to Governance & Strategy Board member openings– Technical & Standards Team voting

• Contributing Member (free)– Technical & Standards Team voting member– Working Group participation – Offer opinions on technical issues

Based around the experiences of: http://www.consortiuminfo.org/