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Thursday, October 30, 2014
“The Future of Drug Discovery:
Challenges, Risks, and Rewards”
Dr. Richard Connell, VP of Ext. Research Solutions, Pfizer
Dr. Jeff Zablocki, Senior Director, Gilead Sciences
Thursday, November 6, 2014
“Cannabis Chemistry 201”
Dr. Christopher Hudalla, Chief Scientific Officer, ProVerde
Laboratories
Dr. Jeff Kiplinger, President & CEO, Averica Discovery Services
10/22/2014
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“Planet of Viruses”
This ACS Webinar is co-produced with the National Chemistry Week 2014
www.acs.org/acswebinars Recordings will be available to ACS members after three weeks
Beth Hamelin Chemist, Centers for Disease
Control and Prevention
Carl Zimmer New York Times Journalist and Author,
Fellow, Yale University
10/22/2014
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A Planet of Viruses
Carl Zimmer
American Chemical Society Webinar,
October 23, 2014
nbcnews.com
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http://news.nationalgeographic.com news.nationalgeographic.com/news/2014/09/140925-mapping-the-spread-of-ebola/
As of October 14: 8914 cases, 4447 deaths (CDC)
Ebolavirus
cdc.gov
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Ebola virus (blue) emerging from an infected cell
(yellow)
NIAID flic.kr/p/o15Y5n
First documented in 1976; 2998 deaths
in all Ebola outbreaks before 2014.
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Franquet's Epauletted Bat
(Epomops franqueti)
Photo by Jakob Fahr
inaturalist.org/taxa/40804-
Epomops-franqueti
Olival and Hayman, Viruses 2014, 6(4), 1759-1788;
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Ebola: 7,445 deaths ever
Area proportional to number of deaths
Ebola: 7,445 deaths ever
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Influenza: over 250,000 deaths per year
HIV: 1.6 million deaths per year
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Smallpox: ~ 5 million deaths
per year in the 20th century
Where do viruses come from?
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From Zimmer,
The Tangled
Bank (Second
Edition)
Faria et al Science 3 October 2014: 346:56-61
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Cave of Crystals, Mexico
Erik K. Veland http://www.flickr.com/photos/16346469@N00/437201319
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https://picasaweb.google.com/zichali
Vostok
http://www.flickr.com/photos/nsf_beta/4514670771/
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Yau et al, PNAS 2011 108:15 6163-6168
Our inner ecology
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How many viruses are there?
How many viruses are there?
Answer: 10000000000000000000000000000000
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200,000,000
light years
Distance: Hendrix, Advances in
Virus Research 2005 64:1
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Time to surrender?
Smallpox
World Health Organization Pharaoh Ramses V
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Edward Jenner
Wikipedia
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Rabies: 69,000 deaths a year
Lankester et al Science 2014 345:1562-1564
web.stanford.edu/virus
Lankester et al Science 2014 345:1562-1564
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Get ahead of the next outbreak
Guinea deforestation
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http://elifesciences.org/content/3/e04395
The Real Hot Zone
Use viruses as
medical tools
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Tree-top Disease
Bill Tyne
http://www.flickr.com/photos/85265584@N00/
2288300863
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ent.iastate.edu/dept/faculty/bonningb/fil
es/images/baculovirus.jpg
See Hoover et al, Science 2011 333:1401
Baculovirus
From Tree-top Disease to Flu Vaccine
Flublok (Protein Sciences)
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Use viruses to fight other diseases
David Vetter, a boy with
X-linked severe combined immunodeficiency
Murine Leukemia Virus
MicrobeWiki
See Hacein-Bey-Abina et al N Engl J Med 2014; 371:1407-1417
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Gene therapy
See Hacein-Bey-Abina et al N Engl J Med 2014; 371:1407-1417
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For more
information, visit
carlzimmer.com
