Plasma Med # 1 1st International Conference on Plasma Medicine

Corpus Christi, TXOctober 15-18, 2007

Plasma Med # 1 1st International Conference on Plasma Medicine

Corpus Christi, TXOctober 15-18, 2007

Plasma – Foundation for a New Revolution in Healthcare

Plasma – Foundation for a New Revolution in Healthcare

Richard M. Satava, MD FACSProfessor of Surgery

University of Washington

and

Senior Science AdvisorUS Army Medical Research and Materiel Command

Richard M. Satava, MD FACSProfessor of Surgery

University of Washington

and

Senior Science AdvisorUS Army Medical Research and Materiel Command

Presenter Disclosure Slide*Presenter Disclosure Slide*

Richard M. Satava, MD FACS

METI, Inc

Preimera BC/BS

InTouch Technologies, Inc

Karl Storz

Stryker

SimuLab

US Surgical

* There will be no discussion of any products from these companies

“The Future is not what it used to be”

….Yogi Berra

“The Future is not what it used to be”

….Yogi Berra

Disruptive Visions

“The Future is here …

. . . it’s the Information Age”

“The Future is here …

. . . it’s the Information Age”

Current Visions

New technologies that are emerging from Information Age discoveries are changing our basic approach in all areas of medicine

. . . EXAMPLES

New technologies that are emerging from Information Age discoveries are changing our basic approach in all areas of medicine

. . . EXAMPLES

Fundamental Concept

Total Integration of Surgical Care

Courtesy of Joel Jensen, SRI International, Menlo Park, CA

Minimally Invasive& Open Surgery

Pre-operative planningSurgical Rehearsal

Intra-operative navigation

Remote Surgery

Simulation & TrainingPre-operative Warmup

Demonstration of Phase 1

Operating Room with no People

SRI International, Menlo Park, CA January, 2007

“TriCorder” Point-of-care noninvasive therapy

High Intensity Focused Ultrasound for

Non-invasive Acoustic hemostasis

HIFU

Courtesy Larry Crum, Univ Washington Applied Physics Lab

Mechanics to energy

Courtesy Larry Crum, Univ Washington Applied Physics Lab2003

From tissue and instruments

to

Information and energy*

From tissue and instruments

to

Information and energy*

* “The Information Age is about changing from objects and atoms to bits & bytes”Nicholas Negroponte “Being Digital” - 1995

The Fundamental Changes

Perceived Needs for Plasma in Medicine

• Infections disease treatment (eg leishmanaisis )

• Hemorrhage control

• Sterilize equipment/supplies

• Continuous sterilize surgical instruments*

• Drug delivery and activation*

• Cell signaling and regulation*

Infections Disease Treatment

Live/dead before and after treatment

Determine efficacy of inactivation of parasites

20-second treatment: near-complete promastigote inactivation

0.00E+00

1.00E+08

2.00E+08

3.00E+08

4.00E+08

5.00E+08

Pro

mas

tig

ote

co

nce

ntr

acti

on

(1/

ml)

Before treatment 3.48E+08 2.36E+07 3.72E+08

Plasma-treated 8.40E+06 3.80E+08 3.89E+08

alive: dead: total:

Insure safety of other cells and tissues

Leishmanaisis

Hemorrhage Control

Primary hemorrhage control

Wound debridement and stablization

“Electronic dressing” ?

Sterilization

Equipment and supplies

Continuous instrument sterilization

Working at the Cellular Level

Drug delivery and/or activation

Cell signaling and regulation

Cold Spring Harbor Laboratory, Long Island, NY

Femtosecond Laser(1 x 10 –15 sec)

Time of Flight Spectroscopy

Cellular opto-poration

Los Alamos National Labs, Los Alamos NM

Surgical console for cellular surgery

Courtesy Prof Jaydev Desai, Drexel Univ, Philadelphia, PA 2005

Surgical console for cellular surgery

Courtesy Prof Jaydev Desai, Drexel Univ, Philadelphia, PA 2005

Motion Commands

Fig. 2. Top: Fluorescent micrograph of the actin cytoskeleton of an engineered striated muscle cell. Bottom: AFM-acquired topographical map. Wrinkles and lines along the diagonals of the 30 micron square are actin stress fibers under the lipid membrane surface.

Fig. 3. Schematic illustrating the technique for functionalizing AFM tips to identify specific molecules on the cell surface during raster scanning.

Fig. 4. Nanoincision by electroporation. (A) The AFM cantilever is positioned above a region of interest in the cell. (B) Electrical current is injected through the cantilever tip, causing the formation of a nanometer scale pore in the membrane, thru which the AFM tip can be dropped, or other instrumentation attached to the tip, prior to the membrane resealing.

New Surgical Tools

Courtesy Prof Kit Parker, MD, Harvard Univ, Boston, MA 2005

Atomic Force Microscope ManipulatorFemtosecond Lasers

This is what we need . . . . . . but what else can you imagine?

• Infections disease treatment (eg leishmanaisis )

• Hemorrhage control

• Sterilize equipment/supplies

• Continuous sterilize surgical instruments*

• Drug delivery and activation*

• Cell signaling and regulation*

The Future

…….is full of surprises and unintended consequences