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PLATELET RICH PLASMAPlasma Kaya Trombosit (PKT)
disusun untuk memenuhi tugas mata kuliah Biokimia Dasar
Pengampu : Edhana Sahiratmad!a" dr#" Ph#D
Program Magister Ilmu $edokteran Dasar
%akultas $edokteran &ni'ersitas Pad!ad!aran
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(hat is PRP)
Platelet Rich Plasma (PRP) isblood plasma that has been
enriched with platelets
PRP is simply whole blood that iscentrifuged to create an increasedconcentration of platelets with or
without WBCs
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Platelet Ri*h Plasma
frasi plasma darah dengan onsentrasitrombosit !"# ali di atas nilai normal(onsentrasi trombosit pada whole blood)
adar trombosit normal dalam darahberisar antara $#%&%%%' dan !#%&%%%'
plasma aya trombosit mengandung$&%%%&%%% trombosit' pada *olume # mlplasma
Plasma Kaya Trombosit (PKT)
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(hat+s So Spe*ial A,out Platelets)
+ platelets contain granules that store
large numbers of ,growth factors
+ alpha granules released (acti*ated)
when platelets aggregate and adhere
to a site of in-ury or inflammation+ listing of other growth factors.
interleuin"$/ tumor necrosis factor/
transforming growth factor/ insulin
growth factor and more
+ it is the a*ti'ation o- platelets andrelease o- the 'arious gro.th
-a*tors that makes them spe*ial
and is the ke to enhan*ing tissue
repair and healing/
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plasma aya trombosit mengandung 0 ma*am gro.th-a*tordan adar growth in i*o tetap ter!aga setelah
dilauan pembuatan plasma aya trombosit
konsentrasi trom,osit dalam PKT dapat meningkat12dari adar trombosit di dalam darah sehingga adar
gro.th -a*tor di dalam plasma aya trombosit -ugameningkat 12 ecuali 012"$
tingginya onsentrasi trombosit dan berbagai fatorpertumbuhan di dalamnya membuat PKT
diman-aatkan pada ,anak *a,ang ilmu kedokteran
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Platelet Ri*h Plasma Biolog
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(hat Do These 3ro.th %a*tors Do)
directional mo*ement in response to a chemical
stimulus
chemota3is
significant increase in cellular reproduction acti*ity
cell proliferation
performance enhancing
possibly e*en a systemic effect
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The Primar 3ro.th %a*tors Role
in So-t Tissue Healing and Repair
P412
5 polypeptide chains
6B/ BB and 66 types(6B in human platelets)
stored in alpha
granules in platelets receptors are found intendon/ cartilage/syno*ium andelsewhere
T12 beta
polypeptide/ multiplechains/ T12 beta"$most studied form
found in platelets/bone/ cartilage 7macrophages
receptors are uni*ersalin cells throughout thebody
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immediate
(within # minutes) second messenger stimulation
inflammatory response
early
(!%min to 8 hours) 9"R:6 stimulation/ protein synthesis chemota3is (draws cells to the area)
late (8"58 hours) fibroblast mitosis
E--e*t o- T3%45 on Tissues
actually inhibits cell growth
more of a modulator of cell growth/differentiation
*ery important in wound repair
E--e*t o- PD3% on Tissues
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E--e*t o- Platelet 3ro.th %a*tors on Tissues
it appears that through a comple3series of biochemical and cellular
e*ents
these growth factors cause a rapidand sustained increase in the number
of fibroblasts in an area and thenthrough a poorly understood
interaction among factors modulatescellular acti*ity
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PRP IS 67T/
;tem Cells9;Cs
ipocytes
Bone 9arrow