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GROUP 3
Andika Razzanur 1218011014 Asep Setya Rini 1218011023 Eduard 1218011042 Gheavani Legowo12180110!
"uzai#ah 12180110$2 %arina &e''ova 121801108! &i(o A'drin Avesina 121801111 Sartika Sa)tri 121801113* Se+a Riandini121801113$ Si'vi ,iroatu' Aini 1218011143 Ste-hani Gista L 121801110 .sa zsa /eryana 12180111** Anasthasia / A 12180111*8
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LEAR&&G 5E67ES
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"9:ERSE&S779
"ypersensitivity re-ers to e;(essive<undesira'e rea(tions produ(ed y
the nor#a' i##une syste#= "ypersensitivity rea(tions re>uire a
pre?sensitized @i##une state o- the
host=
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"9:ERSE&S779
TYPE 1 TYPE 2 TYPE 3 TYPE 4
gE ediated
6'assi( A''ergy
gGBgediated
r( 'ysis
gG ediated
##une(o#p'e;Cisease
7 (e''
Ce'ayed 7ype
"ypersensitivity
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S9S7E6 LD:DSER97"EA7SDS @SLE
6hroni( #u'tisyste# ina##atorydisease
Asso(iated with anor#a'ities o-i##une syste# Resu'ts -ro# intera(tions a#ong
geneti(< hor#ona'< environ#enta'< andi##uno'ogi( -a(tors
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&6CE&6E
SLE aFe(ts 2 to 8 persons per 100
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:A7":"9SLG9
Autoi##une rea(tions dire(tedagainst (onstituents o- (e''nu('eus< C&A
Antiody response re'ated to and
7 (e'' hypera(tivity
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6L&6AL A&/ES7A7&
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CERA7LG6A&/ES7A7&
SA& &E6%
CE/R79
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us(u'oske'eta'
:o'yarthra'gia with #orning stiFness
ArthritisSwan ne(k )ngers
D'nar deviation
Su'u;ation with hyper'a;ity o- Hoints
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6ardiopu'#onary 7a(hypnea
:'eurisy
Cysrhyth#ias
A((e'erated 6AC
:eri(arditis
Rena' Lupus nephritis
Ranging -ro# #i'd proteinuria tog'o#eru'onephritis
:ri#ary goa' in treat#ent is s'owing theprogression
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&ervous syste#
Genera'izedB-o(a' seizures
:eriphera' neuropathy
6ognitive dys-un(tionCisorientatione#ory de)(its:sy(hiatri( sy#pto#s
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"EA7LG6
/or#ation o- antiodies against 'ood (e''sAne#ia
Leukopenia 7hro#o(ytopenia
6oagu'opathy
Anti?phospho'ipid antiody syndro#e
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CAG&S76 S7DCES
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CAG&S76 7ES7
66 -or he#ato'ogi( pro'e#s
DA -or 'upus nephritis
I?rays o- aFe(ted Hoints
6hest ;?ray -or pu'#onarypro'e#s
E6G -or (ardia( pro'e#s
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A&AGEE&7 A&C 7REA7E&7
Crug therapy&SACs
Anti#a'aria' drugsSteroid?sparing drugs
6orti(osteroids
##unosuppressive
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A(ute interventiononitor weight and J
6o''e(t 24?hour urine sa#p'eAssess neuro'ogi(a' status
E;p'ain nature o- disease
:rovide support
A#u'atory and ho#e (are
Reiterate that adheren(e to treat#ent doesnot ne(essari'y ha't progression
ini#ize e;posure to pre(ipitating -a(tors K-atigue< sun< stress< in-e(tion< drugs
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SYNDROME
severe e;pression o- erythe#a#u'ti-or#e
invo'ves the skin and the #u(ous#e#ranesora'< nasa'< eye< vagina'< urethra'< G< and
'ower respiratory tra(t #u(ous #e#ranes potentia' -or severe #oridity and even
death=
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E79LG
n-e(tion
Crug?indu(ed
a'ignan(y?re'ated
6o''agen vas(u'ar disease diopathi(
2?0 o- (ases
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Haynes, B.F. and Fau!, ".S. #2$$1% D!s&'de's &( )*e!++une sys)e+. n P'!!-es &( n)e'na Med!!ne
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:athophysio'ogy
&ot (o#p'ete'y understood
Epide#io'ogy 0=4?1=2 (ases per #i''ion per year
a'e?to?-e#a'e ratio is 2M1
6au(asian predo#inan(e has een reported
orta'ity rate M 3?1 @or 30
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A&/ES7A7&
S0!n Erythe#atous #a(u'es e;tending over
the -a(e ne(k< trunk and e;tre#ities
Eyes :eriorita' redness and swe''ing=
M&u)*Mswe''ing o- the 'ipsJ #i'd u'(eration=
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*es)M
('ear good air entry i'atera''y
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CAG&S76
Skin iopsy
"istopato'ogy
'ood tests
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7REA7E&7
supportive re#ova' o- the oFending agent rep'a(e#ent o- uid 'osses
si#i'ar to urn vi(ti#s ana'gesi(s a'' drugs started within the past #onth
shou'd e dis(ontinued avoid Si'vadene @si'ver su'-adiazine
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7REA7E&7
7he ro'e o- (orti(osteroids in S5S and 7E& is high'y(ontroversia' ased on a review o- the 'iterature< there does not appear to e
a (onsensus on the use o- steroids in the treat#ent o- S5S and 7E&
Asepti( te(hni>ue to avoid in-e(tion Dse o- adhesive #ateria'< oint#ents< and (rea#s shou'd eavoided :atients shou'd e (overed in a ('ean white sheet
Ceride#ent o- ne(roti( tissue #ay e ne(essary
:rophy'a(ti( antiioti( therapy is no 'onger given 6rossrea(tivity with the drug that initiated the 7E& the risk o- se'e(ting -or resistant organis#s