Date post: | 18-Jan-2016 |
Category: |
Documents |
Upload: | roxanne-simon |
View: | 217 times |
Download: | 0 times |
PMCY 4200-Pharmaceutical Sciences II
Arthur G. Roberts
Résumé
• General Skills– Pharmacokinetics/Pharmacodynamics (PKPD)
Calculations• Computer Skills– PKPD software: Phoenix WinNonLin
Pharmwiki
Class Facebook
Optional
Don’t Need to Memorize
Will Be Provided
Beginning of Each Chapter: Tells you what you need to know
End of Chapter: Problems for Students
End of Book: Answers
Other
• Undergraduate vs. Graduate (MS)• Extra points– 1 point• Mistakes in the lectures and other materials• Contradict myself• Spelling errors for drugs or enzymes
– 0.5 point• Serious grammatical errors
• Information is Cummulative
Undergraduate vs. Masters
• Undergraduate– Multiple choice and Fill-in– Straight-forward math problems- Excel worksheet
(“Plug and Chug”)• Masters– All the undergraduate stuff +– Problems from the back of the Chapters– Pheonix WinNonLin project
Phoenix WinNonLin• Industry standard for Pharmacokinetic and
Pharmacodynamic Modeling- Something to put on your résumé.
MS Students: Phoenix WinNonLin Project Goals (Due next week)
• Get login and password at end of class.• Go to www.pharmwiki.org for Phoenix
instructions Download and install Microsoft Remote Desktop
• Put a folder link on your remote desktop to your computer
• Get Phoenix licensing to work.• You will show me at the end of class next week
that you can do it.
Teaching Style
THERAPEUTIC RELAVENCELecture #1
• Pharmacon• Pharmacokinetics• How the body handles a drug over time
• Pharmacodynamics• How the drug affects the body over time
• [Drug] in the blood plasma• Red blood cell count• Level of pain relief• Drug removal rate in the urine• Absorption rate in the stomach• Tumor reduction level
Plateaus
Warfarin
Time Delays: Administration vs. Response
Time Delays: Fraction of LeukocytesPaclitaxel
Pharmacokinetic Variability
Pharmacodynamic Variability
Nonadherence
3-6 Years 6-7 Years 0.5-2
Phase I
5,000-10,000
250 51
Phase 2 Phase 3
Find
Tar
gets
Discovery Preclinical Clinical
Volunteers
20-100
100-500
1,000-5,000
FDA Scale-up
Market
Innovation.org and DiMasi, et al. 2003*Inflation Adjusted
$420 million* $585 million* Total= >$1 billion
Industrial Perspective
Industrial Perspective