AlPure' Anibodies to a ns rowth fadbr ando>ncogene pro we ppoduced In sheep, g nh
upepti4esUse d.chromatogri p yantio ' +wbich are inonospecific and
non-specifc readlois.&i . ~~~~~~-AnonIltoh B 06'8''itocince Ic. now odei
0 3ssR-a p21 ffNx' Atio
0.'';--UIU- p21 AIN.m bbd
.'$ 0 -.,;PAIu. nbd
m jaw -,A
AfflPure"AnUbodies are valuable research tools forcetstwo in e fields of TGF-s aoncoanesaon B ioes c nt top ing a coiitinu-
ous source 01 lcal reagents to tfie cancer-relted_~searh communitr is stengthened by our n
3 4 tcid~~Imsncreasedihuanreoue and ourrn~orgtt of woi*ng _ lt
Ckrb No, 124 an RemiSO Sere Cerd
m
Triton BiosaciencsAnId~iiuy~ SbuSOCyA y of Shdl CO -alio.
Actiuug so of b rgontsfwnm Tu4rr 4,erai,* TRiin-
Whqlzhlst
mnethod deivrputt pno~t0nd ewui
Well to begin with, you won't compromisehigh sample load with poor resolution. Infact, our way gives you 10 times greaterload and also 10 times better resolution- at the same time!Sounds too good? Just try advanced
electrofocusing by using Immobilinre. It'sthe only system available that lets youimmobilize the pH gradient within thegel, puts an end to drift, cuts out conduc-tivity gaps and gives you infinite stability.Look up J. Biochem. Biophys Methods
8 (1983) 157-172, and find out how pre-parative electrofocusing separates proteinsin quantities of up to 1 gram - completelyfree from low molecular weight conta-minants. Better still, just fill in thecoupon and get all the facts. Or try it
straight away, and I'll see that we giveyou an attractive discount on your firstorder.
Please send me your new brochure onThe Immobiline System for analyticaland preparative electrofocusing.
Please send me your latest catalogueon Quality Chemicals for electro-phoresis and electrofocusing.
O Please call me.
Name
Company/Institution
DepartmentAddress
L-i~~~~~~~~:
7hE INCEN7iVE GROUPLKB-Produkter AB, Box 305, S-161 26 Bromma, Sweden. Tel. + 46(8)98 00 40, telex 10492
Antwerp (03) 218 93 35 Athens-Middle East +30 (1) 894 73 96 Copenhagen (01) 29 50 44 Hongkong (852) 5-555555London (01) 657 88 22 Lucerne (041) 57 44 57 Madras (044) 45 28 74 -Moscow (095) 256-9002 Munich (089) 85 830
Paris (06) 928 65 07 * Rome (06) 39 90 33* Stockholm (08) 98 00 40 * Tokyo (03) 293-5141 Turku (021) 678111Vienna +43 (222) 92 16 07 Washington (301) 963 3200 Zoetermeer (079) 3192 01
Over 60 qualified representatives throughout the world.
Circle No. 34 on Readers' Service Card
Newstandards of
vibration isolation
ICRO-g®systems
* Standard Post-Mount Isolators combined with Series 76 Honeycomb Tops achieveexceptional levels of attenuation and damping.
* Gimbal Piston isolators attenuate both vertical and horizontal vibration in a singlecompact module. Wide range of load ratings.
* New Series 76 honeycomb core tops offer superior damping, rigidity and structuralintegrity.
* Standard sizes to 4' x 12'; top thickness 2", 4", 8" and 12".
Technical Manufacturing Corporation15 Centennial Drive, Peabody, Massachusetts 01960
,t Telephone: 617-53246330 * Telex: 951408
DAMO(DqtyaEootd by4
S- c OoseOnc Oa4ne O.Oenc
ww_BawoidMa..o0N
l"l'l1lTl7P+ a T r~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~VLVvT
1.5 Hz 2.5 5 10 20 40
Circle No. 88 on Readers' Service Card
REF-IlComputerizes your REFERENCES
and prepares your BIBLIOGRAPHIESo Maintains a data base of referencesO Searches for any combination ot authors, years of pubikation,
reterence title (or any words in the title), and topics coveredby the reference
O Formats bibliographies exactly as you want themO Alphabetizes references 0 Menu driven dialogueO Abbreviates journal titles O Compact storage tormatO Runs on any video terminal El 20 lines of comments for
and printer each reference
IBM PC/XT/AT, MS-DOS, CP/M 80 ... 1 00
RT-1 1, TSX-Plus, RSX-1 1, P/OS ...... $2500
VAX/VMS (native mode) .......... 35000
MAUAL $15"ANY
M ANUAL
& DEMO 0m322 Prospect Ave., Hartford, CT 06106(203) 247-8500Connecticut residents add 72%% sales tax.
PUBLICA;ICAiQUAITY
CHARTS ANDGRAPHS
from your IBM PC, XT, ATand HP or compatible plotter
Wp.T C amwmow
S
I 0-
AlS;d .0
* Error Bars * Smooth lines,Clean diagonals * MovableLabels * Log and Semi-log scales* and more...Load data from Keyboard or disk,any ASCII or DIF file (includingLOTUS 123)This and other new microcomputertools for the scientist. Cal! or writefor our FREE catalog.
JANDEL SCIENTIFIC2656 Bridgeway, Sausalito, CA 94965
800-874-1888 (outside CA)415-331-3022 (inside CA)
Circle No. 83 on Readers' Service Card
Science, Arms Control
National SecurityThis pressing issue for all scientists is thefocal point of these new titles from AAAS:
THE VERIFICATION CHALLENGE: Problems and
Promise of Strategic Nuclear Arms Control Verifica-
tion, by Richard A. Scribner, Theodore J. Ralston,and William D. Metz. Available November 1985, ca.
200pp., $15*.STRATEGIC NUCLEAR ARMS CONTROL VERIFICA-
TION TERMS AND CONCEPTS: A Glossary, byRichard A. Scribner and Kenneth N. Luongo. AAAS
(1985) 48pp., $2.50*.STRATEGIC NUCLEAR ARMS CONTROL VERIFICA-
TION:An Annotated Bibliography, 1977-1984, byRichard A. Scribner and Robert Travis Scott. AAAS
(1985) ca. 108pp., $7.50*.
THE STRATEGIC DEFENSE INITIATIVE: SomeArms Control Implications, by Jeffrey Boutwell and
Richard A. Scribner. AAAS (1985) 48pp.. $2.50*.
To order, write to: Committee on Science, Arms
Control, and National Security, AAAS, 1333 H Street,
NW, Washington, DC 20005.
(* Please add $1.50 postage and handling per order. Allow
4-6 weeks for delivery. AAAS members receive a 20 percentdiscount on listed prices.)
Circle No. 17 on Readers' Service Card
S-4'4,-P4 Spo:*
.
THE FIFTH ANNUAL CONGRESS FOR
HYBRIDOMA RESEARCHJANUARY 26 - 29, 1986
BALTIMORE CONVENTION CENTER, BALTIMORE, MARYLANDCo-Chair7nen:
Zenon Steplewsid, The Wistar Institute, Philadelphia, PA*Hilary Koptoski, The Wistar Institute, Philadelphia, PA*Joseph Dave, Washington University, St. Louis, MOKeynote Speaker: Mark Dais, Stanford Unhiery, Stanford, CA Title: T-cell Receptor Gene Structure and Function.
are planning six Wbrking Group Meetings on "Murne Monoclonal Antibodies Arailable for Clinical Application". These Group Meetings will be restricted to 20participants each in the follocing fields:
Group A: Immunohistological Diagnosis Group D: Immunotherapy of Solid TumorsLeader: 1 Schlom, NCI, Bethesda, MD Leader: A Houghton, Sloan Kettering Cancer Center, New brk, NYRepporteur: M. Nut, Laboratoro Di Immunologia, Rome, Italy Repporteur: S. Ferrone, New Ybrk Medical College, Valhalla, NYGroup B: Radiolmmunoscintigraphy Group E: Immunotherapy of Leukemia and LymphomaLeader: J.-F Chatl, Center Rene Gauducheau, Nartes, France Leader: J. Ritz, Dana Farber Cancer Institute, Boston, MARepporteur: 1 Poe, Victoria Hospital, Ontario, Canada Repporteur: K Foon, University of Michigan, Ann Arbor, MlGroup C: Antigens Shed by Tumor Cells Group F: ImmunoconjugatesLeader: R. Bast, Duke University, Durham, NC Leader: K. Krolick, University of Texas, San Antonio, TXRepporteur: l-Y Douillard, Center Rene Gauducheau, Nantes, France Repporteur: l Fulton, Southwestern Medical School, Dallas, TXIt is our intent to select participants acft4fy invohed in the above listed research for in-depth discussion of progress made recentlyThe entire day of Monday, January 27, 1986 will be avilable for these group discussions. The consensus reached by the groups will be presented by the Repporteurstothe whole Congress and results of these discussions will be published in Hybridoma.Investigators interested in participating in Group Meetings should send a short summary to Dr. Ralph Reisfeld, Scripps Clinic and Research Foundation, 10666 NorthTorrey Pines Road, La Jolla, California 92037 b November 30, 1985.Workshop lbpics & Chairmen:HUMAN REPERIOIRE and AUTOIMMUNE DISEASE MONOCLONAL ANTIBODIES in DISSECTING NORMAL and MALIGNANT STEM CELLS
A. Notdns, NIH, Bethesda, MD. 1. Bernstein, Fred Hutchinson Cancer Center, Seattle, WA.GENETIC PROBES ISOTYPE SWITCH VARIANTS IN ANALYSIS of ANTIBODY FUNCTION
JlD. Capra, University of Teas, Dallas, TX. M. Scharff, Albert Einstein College of Medicine, New Ybrk, NY
Poster Sessions: TECHNOLOGICAL ADVANCES IN HYBRIDOMA RESEARCH
Participants are invited to submit abstrats for the poster sessions. These abstracts will be reviewed up until the time of the meeting; however,only those accepted by Nov. 15 will be published In the loumnal, Hybridoma. Contact Dr. Zenon Steplewski (215) 898-3924.
Organized by Scherago Associates, Inc., in conjunction with the journal Hybridoma.
REGISTRATION FEES:$400 On-site registration - includes a one year subscription or renewal to the joumal, Hybridoma.$350 ADVANCE REGISTRAI1ON - (Received by Nw. 15) - Includes a one year subscription or renewal
to the joumal, Hybndoma.$ 75 STUDENT REGISrRATION - Student status must be confirmed in writing by department chairman.4-7 registrations received together from same organization $300 each. Includes 4 joumal subscriptions only8-10 registrations received together from same organization $200 each. Includes 4 journal subscrptions only
Larger group rates available upon request.Cancellations must be received in writing by December 19,1985.
Attendance will be limited. Make checks paable to: Scherago Associates, Inc., DNA/HYBRIDOMA S 10-11
Please reserve space(s): Registraton Fee of $ enclosed.O Please send abstact form.
Name
Dept. Organization
Street
City State ZipTelephone: (Retum to: Hybridoma; do Scherago Associats, Inc.
Dept. S-1O-11, 1515 Broadway, New vbrk, NY 10036 * (212) 730-1050
Circle No. 56 on Readers' Service Card 119II OCTOBER 1985
Smith Kline&French Laboratones
Announces
the Fourth in Its Series ofAnnual Research Symposia
Co-Organizers:George Poste and Stanley T. Crooke
New Frontiers in the Study ofGene Functions
April 8-10, 1986
Sheraton Valley Forge HotelValley Forge, Pennsylvania
Tentative Program
J. AlwineR. AxelS. BenkovicM. BirnsteilR. BrinsterG. Felsenfeld
G. FinkM. GellertC. GrossD. HognessL. HoodR. Jaenisch
A. JohnsonG. KhouryP. LederR. PalmiterG. RubinR. Sauer
P. SharpM. ShulmanS. Tilghman.R. TjianR. WeinmanH. Weintraub
For Additional Information and Registration Forms, Contact:
Ms. Buff BiddleSymposium Coordinator
Post Office Box 7929Philadelphia, Pa. 19101
0 =continuity of life A =quest for knowledge FO =resolutionI126
I(NW6O)M
SCIENCE, VOL. 230
0
Most laortorIles report to
otht hey moer rlizd how muchIsaple wore loi l thy us
"'Speed Vac".. .. Th ese of smepleprepartUo is also a big adange-. Ple
your saple in hid tubestorwvis ad un
611SOW v o"IN"S... Me cress cn.amIn
losms,m oping, foaming and s am s
will be concented at the bottom of the tube...
NPLC sample preparation wherea dned, concentrated sample isimportant.ILC sample preparation.., asabove.PHOSPHUID separation byHPLC total evaporation ofAcetonitrie- Water Solvent.INTERFER purification bydialysis and evaporation.TE-CYCUC anti-depressant drugblood levels measured after aseries of extractions andevaporations to dryness.HORMOIE and Enzyme assays.
Circle No. 89 on Readers' Service Card
- -- The Neurosciences Institute Gerald M. Edelman, DirectorW. Maxwell Cowan, Chairman,-_- ___ of the Neurosciences Research Program Scientific Advisory Committee
The Neurosciences Institute announces that its facilities are open to interested scientists for the forth-coming academic year. Located on the campus of The Rockefeller University, the Institute provides opportunitiesfor individuals and small groups to design their own experiments or to develop theoretical constructs within a broadrange of disciplines related to the neurosciences. Although laboratory facilities are not available, convenient arrange-ments can be made for planning and review of experimental and theoretical work. Scientists from several disciplinesmay meet to discuss specific experimental plans; alternatively, facilities can be provided for those already workingin collaborative arrangements. Resources are also available for preparation of scientific reviews or monographs;a publications program is available for interested authors.
Fellows design their own programs and arrange their own schedules. In addition, they are encouragedto invite visitors or hold small conferences with colleagues from other institutions. Housing, travel expenses, andper diem allowances are provided. Periods of stay may range from several days to half a year, during which timeample occasions exist for interactions with other Fellows and visitors to the Institute. Opportunities for Junior Fellowsat the graduate student and postdoctoral levels are available under the sponsorship of Fellows. An expert staff isavailable to aid Fellows and visitors in the use of Institute facilities, which include:
* an extensive neurosciences library* individual office space and conference areas* special computing resources for neural modeling and theoretical work* editorial, bibliographic, and secetarial assistanceProposals for use of the Institute's resources should be made by means of a two- or three-page letter
including a description of scientific or scholarly plans, anticipated length of stay, and any special requirements ofthe proposed program. A Descriptive Guide reviewing the facilities and application procedures in further detail willbe sent upon request.
For further information, write or call Dr. W. Einar Gall, Research Director, The NeurosciencesInstitute, 1230 York Avenue, New York, New York 10021, telephone (212) 570-8975.
II OCTOBER 1985 197