SCIENCE publishes each Friday, except the last Fridayof the year, and is mailed on issue date. Personneladvertising is accepted only with the understanding thatthe advertiser does not discriminate among applicantson the basis of race, sex, religion, age, color, nationalorigin, handicap, or sexual preference. SCIENCE re-serves the right, in its discretion, to decline to publishadvertisements submitted to it.

UNE CLASSIFIED ADVERTISEMENTSDEADUNE: Thursday, 10 a.m., 2 weeks prior to issuedate. Advertising is accepted only in writing.POLICIES: All classified ads will be edited and typesetaccording to SCIENCE style guidelines. NO ABBREVIA-TIONS. Any deadline for applications stated in ad mustbe at least 2 weeks after date of issue in which adappears.CLASSIFICATION: SCIENCE publishes line classifiedads under the following headings: Positions Open,Employment Agencies, Fellowships, SituationsWanted, Courses and Training, Meetings, Announce-ments, and Marketplae. Advertisers should specifyclassification desired; however, SCIENCE reserves theright to decline classification requests which it believesmay be misleading to readers.RATE: $41 per line, $410 minimum, per week. One lineequals 52 characters and spaces; centered headingsequal 32 characters and spaces per line. No charge foruse of blind box number. No agency commission for adsless than 40 lines. No cash discount. Prepayment re-quired for all foreign ads. Purchase orders required forall other advertising.To ESTIMATE ad cost, structure ad copy on a 52-

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For rates, deadlines, and other information about frac-tional display ads (1/6 page and larger) and all Market-place listings of available products and services, con-tact:

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RESPONSES TO EMPLOYMENT ADSApplicants should read Positions Open ads carefully inorder to submit all required material when responding,and should especially check for any stated deadline forreceipt of applications.SCIENCE encourages applicants for positions to investi-gate employment laws, nondiscrimination policies, visarequirements, and cultural differences in the countryadvertising for employees.To reply to a blind box ad, address correspondence to:

Box (give number)SCIENCE Clmlfied Advertising1333 H Stret, NW, Room 940

Washington, DC 20005

POSITIONS OPEN

Entry level ASSISTANT PROFESSOR positionavailable now at Pennsylvania State University College ofMedicine in Hershey to join multidisciplinary group inmicrobiology/immunology and medicine/hematology/oncology/infectious disease involved in basic HIV re-search and AIDS clinical trials. M.D. or Ph.D. withbackground in molecular biology and demonstrated ex-pertise in HIV detection techniques required. Sendcurriculum vitae to: M. Elaine Eyster, M.D., DivisionofHematology, The Milton S. Hershey Medical Cen-ter, P.O. Box 850, Hershgy, PA 17033, by 31 March1990. An Equal Opportunity/Affirmative Action E,nployer.Women and minorities are encouraged to apply.

TRENTON STATE COLLEGEASSISTANT PROFESSOR

CELL BIOLOGISTTrenton State College (TSC) seeks candidates recently

trained in cell biology to represent this discipline in astrong undergraduate program. Teaching introductoryand advanced courses, the latter involving light andelectron microscopic techniques. Oversight of a modemlight and electron microscope facility is also required.Tenure track, Ph.D. required. Applications will com-mence 1 April 1990. Credentials and curriculurn vitaeshould be sent to: Dr. Albert F. Eble, Trenton StateCollege, Department of Biology, Hillwood Lakes,CN 4700,Trenton, NJ 08650-4700. To enrich edu-cation through diversity, TSC is an Affirmative Action/Equal Opportunity Employer.

ASSISTANT OR ASSOCIATE PROFESSOR,BIOLOGY. Tenure-track position available 19 August1990 primarily teaching biology for nonmajors. Doctor-ate required; computer-assisted instruction and grantproposal writing experience important; specialty to com-plement current faculty desirable. Send letter of applica-tion, curriculum vitae, all graduate/undergraduate tran-scripts, and three letters of recommendation by 22 April1990 to: James Schlough, Biology Dcpartmcnt, Uni-vcrsity of WLsconsi-Whitewater, Whitcwatcr, WI53190. UW-Whitewater is an Afirmative Action/Equal Op-portunity Employer.

The Departnent of Biology at Morehouse Collegeinvites applcations for a tenure-track position at tASSISTANT/ASSOCIATE PROFESSOR level foran environmental biologist. Applicants must hold aPh.D. in either ecology or environmental science. Teach-ing responsibilities will include a general course inecology for seniors and a topics course in environmentalbiology for juniors and seniors. Faculty members areexpected to maintain active research programs whichinvolve undergraduate and graduate students. Closingdate: 12 May 1990 or until suitabk candidates are found.Applicants should submit their curriculum vitae, gradu-ate school academic transcript, and a statement of teach-ing and research goals, and arrange to have three lettersof recommendation sent to: Dr. J. K Haynes, Chair-man, Department of Biology, Morchouse College,830 Westview Drivc, S.W., Atanta, GA 30314. AnEqual Opportunity/Affirmative Action Employer.

UNIVERSITY OF OKLAHOMACOLLEGE OF MEDICINE

DEPARTMENT OF ANATOMICAL SCIENCESTenure-track positions are available at the ASSIST-

ANT/ASSOCIATE PROFESSOR level. Teaching re-sponsibilities compnse mstruction m gross anatomy orhistology to medical, dental, and graduate students.Candidates should possess a Ph.D., M.D., D.D.S., orequivalent degree and have postdoctoral research experi-ence. Applications are encouraged from candidates withexperience in current departmental programs in cell and/or developmental biology or neurobio[ogy. Expertise inmolecular biology techniques is desirable. Starting datesare negotiable.Curriculum vitae and names of three references should

be directed to:Search Committee

Department of Anatomical SciencesCollege of Medicine

University of Oklahoma Health Sciences CenterP.O. Box 26901

Oklahoma City, OK 73190Closing date for applications is 31 July 1990.We are an Equal Opportunity/Afirmative Action Employer.

POSITIONS OPEN

ASSISTANT PROFESSOR, EAR RESEARCH.Tenure-track position for neuroscientist with researchinterests in auditory or vestibular mechanisms. Musthave 2 years of postdoctoral experience and ability toestablish independent research program. Duties includeresearch training for residents. Joint appointment inbasic science department. Send curriculum vitae, state-ment of research objectives, and three references to: Dr.S. J. Wetmore, Chair, Otolaryngology, West VirginiaUniversity Medical Center, Morgantown, WV26506. Affirmative Action/Equal Opportunity Employer.

Search Reopened. A tenure-track appointment at theASSISTANT PROFESSOR level is available as ofSeptember 1990. Qualifications include a Ph.D. andpostdoctoral experience. The successful candidate will beexpected to teach undergraduate courses in celi biology,developmental biology or genetics, and general biology,and graduate courses in his/her area of expertise andparticipate in our genetic engineering option. Trainingof graduate students at the M.S. level and the ability todevelop a fundable research program are expected. Pleasesend your curriculum vitae, reprints, statement of careergoals and research plans, and the names and addresses ofthree references to: Southern Illinois University atEdwardsvile (SIUE), BiologyDeprtment, Box1651, Edwardsville, IL 62026-1651, Attention:Search Committee. Search will continue until positionis filled. SIUE is an Affirmative Action Employer.

Several tenure-track positions are available at the AS-SISTANT AND ASSOCIATE PROFESSOR levelsin the Department of Cellular and Molecular Physiologyat Harvard Medical School. The department is es 1auyinterested in studies at the cellular and molecular level onthe following research topics: receptors, hormones, sig-nal transduction, and cell motility. Successful candidatesare expected to develop a strong independent researchprogram and to participate in teaching medical andgraduate students. The department is acquiring newlyrenovated facilities and is undergoing substantial expan-sion. Send curriculum vitae, a brief description offutureresearch, and names of three referees to: Search Com-mittee, Deatent of Celiular and Molecular Physi-ology, Harvard Medical School, 25 Shattuck Street,Boston, MA 02115.

ASSOCIATE OR FULL PROFESSORThe Departrnent of Cell and Molecular Biology,

School of Medicine, Medical College of Georgia, seeksan immunologist for a tenure-track appointment as asso-ciate/full professor. The successful candidate should havean established, independently funded research programapplying modem molecular/cell biological approaches tothe study of the immune response. The posinon requiresactive participation in teaching graduate and medicalstudents. Send curriculum vitae, a brief statement ofresearch interests, a copy of two recent publications, andnames and addresses of three references to: Dr. David F.Lapp, Chairman, Search Committee, Department ofCelf and Molecular Biology, Medical College ofGeorgia, Augusta, GA 30912-2100. Preference willbe given to applications received by 15 April 1990. AnEqual Opportunity/Affirmative Action Employer. Females andminorities are encouraged to apply.

ASSOCIATE OR FULL PROFESSORDEPARTMENT OF GEOGRAPHY

Applications are invited for the position ofassociate orfull professor in the Department of Geography, Collegeof Natural Resources, Utah State University. Potentialcandidates for this tenure-track, academic year positionshould have a Ph.D. in geography or closely related fieldand an established record of scholarship in remote sens-ing and GIS with applications in natural resources. Thesuccessful candidate will be cxpected to help develop amultidisciplinary institute (center) for remote sensingand GIS, assist in the development of graduate andresearch programs in geography, and teach remote sens-ing/GIS. He/she should have demonstrated effectivencssin administration, extension experience related to landmanagement agencies, and a willingness to engagc ininternational cooperative efforts. Interested individualsare requested to send curriculum vitae and names offourreferees to: Cliff Craig, Chair of the Search Commit-tee, Department of graphy, Utah State Universi-ty, Logan, Utah 84322-5240. Application deadline isI April 1990 or until a suitable caicfdate is found. UtahState University is an Affirmative Action/Equal Opportunityand IRCA Employer.

SCIENCE, VOL. 247

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Research

Opportunities in

Pfizer Cental Research has several immediateopenings for research assistants within our ex-panding Department ofImmunology and Infec-tious Diseases. You will join multidisciplinaryproject teams engaged in research to discovernovel therapies for a variety of inflammatory,pulmonary and autoimmune diseases. All posi-tions require a BS or MS degree or theequivalent, plus relevant expenence.

Molecular ImmunologistYou will study drug therapy for immunologicaldisorders byconductingin vitr analyses ofdrugaction on the expression of genes in immunecells. Experience with Northerns and basicrecombinant DNA techniques as well as cellculture is required. Ability to work independent-ly and to summarize andcommunicate results ef-fectively is also expected.Inflammation ScientistYou will develop and apply newin vivo modelsin the discovery ofnew treatments for inflam-matory diseases such as rheumatoid arthritis.Familiaritywith ecosanoid and cytDkine biology,as well as strong written and orl communica-tions skills and computer expenence desired.InmmunologistUsing both in vivo and in vitro techniques, youwill study the immune response to infectiousagents. The successful candidate will have ex-perience in one or more ofthe following areas:tissue culture, molecular immunology,lymphokine assays, antibody purifica- riAtion and lymphocyte functional assays.

Pulmonary BiologistYou will participate in a project designed toevaluate the efficacy of novel compounds onpulmonary diseases, using in vivo techniques.Experience developing aerosol drug deliverysystems and measuring the mechanics ofrespi-tion would be helpful.Inlam on Cell BiologistYou will be involved witi a team investigating themechanisms ofrectrutment and activation ofin-flammatory cells in pulmonary diseases. Rele-vant expenence with in vivo models, tissueculture or immunologic methods is desired.

Pfizer's stimulating research environment pro-vides the opportunty to mteract with scientistsfrom several disciplines. In addition, Pfizer of-fers a competitivecompensation/benefit packageand provides generous relocation assistance toour southeastern Connecticut shoreline com-munity. Please send a resume indicatng positionof interest, a description of your research ex-perience, andnamesofthree references to: Mrs.Lorraine C. Corr, Personnel Supervisor, PfizerCentral Research, EasternPoint Road, Groton,CT 06340. An equal opportunity employer.

POSITIONS OPEN

ASSISTANT/ASSOCIATE PROFESSOR. Onelong-term tenure-track faculty position. Begin late Au-gust 1990. Ph.D. required, some teaching experience inanatomy/physiology. Expected to teach upper and lowerdivision courses, conduct research with undergraduatebiology majors, and develop innovative nonsciencecourses. Liberal arts environment. Some possibilities ofgraduate teaching. Letter stating interests, completeresume, transcripts, and three letters of reference dueprior to 21 April 1990 to: Sister John Karen Frei,Associate Vice President, Academic Hcalth ScienccCcnter, Barry University, Miami Shores, FL 33161.

ASSISTANT PROFESSORRESEARCH TRACK

Physiology and Biophysics, University of SouthernCalifornia (USC) Medical School in Los Angeles. Re-quires Ph.D. and/or M.D. Individual with broad experi-ence in metabolism to join group studying regulation ofmetabolic function at various levels oforganization frompopulation studies to cellular level. Experience withcomputer modeling essential; candidates with experiencein gerontology will be preferred. Two years of postdoc-toral experience required. Send curriculum vitae andnames of three individuals from whom references may beobtained to: Dr. Richard N. Bergman, Department ofPhysiology and Biophysics, USC Medical School,1333 San Pablo Street, Los Angeles, CA 90033.Application deadline: 1 April 1990. USC is an EqualOpportunity Employer.

The Department of Biology at Morehouse Collegeinvites applications for a tenure-track position at theASSISTANT/ASSOCIATE PROFESSOR level foran anatomist/developmental biologist to begin in Sep-tember 1990. Applicants must hold a Ph.D. degree ineither anatomy, developmental biology, or cell biologyand must be proficient in the use of the electron micro-scope. Teaching responsibilities will include an inverte-brate and vertebrate anatomy course for sophomores andan embryology course for juniors and seniors. Facultymembers are expected to maintain active research pro-grams which involve undergraduate and graduate stu-dents. Closing date: 12 May 1990 or until suitablecandidates are found. Applicants should submit theircurriculum vitae, graduate school academic transcript,and a statement of teaching and research goals, andarrange to have three letters of recommendation sent to:Dr. J. K. Haynes, Chairman, Department of Biology,Morehouse College, 830 Westview Drive, S.W., At-lanta, GA 30314. An Equal Opportunity/Affirmative Ac-tion Employer.

CELL BIOLOGIST/GENETICIST/BIOCHEMIST

New faculty position, Natural Science and Mathemat-ics (NSM) Department, Trinity College ofVermont, fallof 1990. Teaching duties: 12 contact hours per week inupper and lower division courses (including newcourses). Advising, committee work, research encour-aged. Trinity uses long-term contracts instead of tenure.Salary depends on rank and qualifications; Ph.D. re-quired. Applications (curriculum vitae, graduate tran-scrpt, reference letter addressing teaching, and names,addresses, and telephone numbers of two to three refer-ences) should be submitted to: John F. Heinbokel,Chair, NSM Department, Trinity College, 208 Col-chester Avenue, Burlington, VT 05401. Applicationsaccepted until position filled. Women and minority candi-dates are especially encouraged to apply. Affirmative Action!Equal Opportunity Employer.

CONSERVATION BIOLOGIST. The Departmentof Biological Sciences at Florida Institute of Technoloinvites applications from individuals with strong researchcredentials in ecological systems and dynamics withemphasis on biodiversity or experience in remote sens-ing. The candidate will be expected to develop an activeresearch program with demonstrated potential for extra-mural funding, direct M.S. and Ph.D. students, partici-pate in teaching, and cooprate with faculty in relatedareas of conservation biology. Ph.D. and 2 years ofpostdoctoral experience essential. Position is available forfall of 1990, pending approval. Rank is open and salarywill be commensurate with qualifications and experience.Send curriculum vitae, a concise plan for future research,and names of three references to: Dr. G. N. Wells,Head, Department of Biological Sciences, 150 WestUnivcrsity Boulevard, Melbournc, FL 32901-6988.Equal Opportunity/Affirmative Action Employer.

1248

CHAIR, DEPARTMENT OF PHYSIOLOGYThe Kirksville College of Osteopathic Medicine is

seeking application or nomination of an establishedinvestigator to fill the position of chairperson of theDepartment of Physiology. The candidate should have aPh.D., a record of research in physiology which iscurrently active and funded, leadership qualities, and aninterest in the education of medical students. Pleasesubmit curriculum vitae and names and addresses ofthree references to: Dr. Lex Towns, Chairman, Physi-ology Search COmmnitee, Kirksville College ofOsteo-

pahcMedicine, Kirkssville, MO 63501. Candidatesshould apply by 15 April 1990. Equal OpportunityEmployer.

CHAIR, DEPARTMENT OF PSYCHIATRYAND HEALTH BEHAVIOR. The School of Medi-cine, Medical College of Georgia, is seeking a chair forthe Department of Psychiatry and Health Behavior. Thedepartment has a research orientation with 64 faculty andseven affiliated facilities. The department is currentlyundergoing expansion, and recruitment of new facultywill be a major function of the new chair. Candidatesmust possess demonstrated skills in research teaching,patient care, and administration. Please send nomina-tions and inquiries by 30 April 1990 to: Don W. King,M.D., Department of Neurology, Medical College ofGeorgia, Augusta, GA 30912. Equal Opportunity/Af-firmative Action Employer.

CHAIRPERSONDEPARTMENT OF MICROBIOLOGY

State University of New York (SUNY) at Buffaloannounces the search for the chair of the Department ofMicrobiology in the School of Medicine and BiomedicalSciences. The department has 20 full-time faculty posi-tions and occupies over 30,000 square feet ofspace in themedical schoo campus. The department offers courses inmicrobiology and immunology for students of medicineand dentistry as well as for graduate and undergraduatestudents. The research program of the department isdiverse and excels in many areas of immunology, host-pathogen interactions, and molecular biology. The de-partment offers unique opportunities for growth anddevelopment. The candidate should possess an outstand-ing national and international reputation as an investiga-tor in microbiology, immunology, or molecular biologyand should be experienced in teaching and administra-tion. Persons interested in this position should sendcurriculum vitae, a description of research activities andadministrative experience, and the names of three refer-ences to the Chairman of the Search Commnittee: PearayL. Ogra, M.D., Department of Pediatrics, Children'sHospital, 219 Bryant Street, Buffalo, NY 14222.Telephone: 716-878-7587. FAX: 716-878-7631. Allmaterials should be received by 30 June 1990. SUNY isan Equal Opportunity/Affirmative Action Employer.

DIRECTORCOOPERATIVE INSTITUTE FOR MARINE

AND ATMOSPHERIC STUDIESThe University of Miami's Rosenstiel School of Ma-

rine and Atmospheric Science seeks a director for theCooperative Institute of Marine and Atrnospheric Stud-ies (CIMAS). CIMAS was established in 1977 to providea formal mechanism for scientific collaboration betweenthe Rosenstiel School and the National Oceanographicand Atmospheric Administration (NOAA), particularlythe Atlantic Oceanographic and Meteorological Labora-tories and the Southeast Fisheries Center. It is currentlyfocused on aspects of ocean physics which impact onchmatic processes and systems and on the large-scalemarine ecology of fish and crustaceans. Increasing em-phasis will be placed on the physical and biologicalcomponents of"Global Change." The CIMAS director isa tenured faculty member of the University of Miami'sRosenstiel School. Applicants should have a distin-guished record of research in an oceanographic/atmo-spheric speciality and experience in scientific projectmanagement and be qualified for full professor rank intheir specialty.

Applications should be sent to: Dr. Bmce R. Rosen-dahl, Dean and Weeks Chair, Rosenstiel School ofMarine and Atnospheric Science, 4600 RickenbackerCauseway, Miami, FL 33149.

The University of Miami is an Equal OpportunityEmployer.

The Texas College of Osteopathic Medicine is nowaccepting applications for CHAIRMAN OF THE DE-PARTMENT OF ANATOMYAND CELL BIOLO-GY. The department currently has 12 faculty memberswhose research covers a wide variety of areas. Viablecandidates should have an established research program,teaching experience (preferably medical), and demon-strated managerial skifls. Applications must be receivedby 1 June 1990, and accompanied by curriculum vitaeand a list of three individuals who may be contacted asreferences. Applications should be sent to:

Dr. Paul F. CookChairman, Anatomy Search Committee

Department of Microbiology and ImmunologyTexas College of Osteopathic Medicine

3500 Camp Bowie BoulevardFort Worth, TX 76107-2690

Texas College ofOsteopathic Medicine is an Equal Opportu-nity/Afirmative Action Employer.DIRECTOR OF FACULTY DEVELOPMENTBiomedical scientist with strong interest and experi-

ence in teaching to set up and conduct a faculty develop-ment program for both basic science and clinical faculty.Faculty appointment available in Division of Educationand Medical Humanities with possible joint appointmentin appropriate basic science department. Formal creden-tials in faculty development not mandatory but outstand-ing teaching and interpersonal skills essential. Inquiriesor applications with curriculum vitae should be directedto: Clinton H. Toewe II, M.D., Associate Dean forEducational Affairs, Eastern Virginia Medical School,P.O. Box 1980, Norfolk, VA 23501.

EVOLUTIONARY/ECOLOGICAILPOPULATION BIOLOGIST

A temporary position starting fall of 1990 in theBiology Department of the University of Rochester. APh.D. is required. Participate in undergraduate andgraduate teaching in one or more ofthe above areas. Theappointment will either be for 1 year with full-timeteaching responsibilities, or 2 years with half-time teach-ing and half-time research responsibilities. The latteroption depends upon the successful negotiation of half-time postdoctoral support from one of the followingfaculty: J. Jacnike, J. Werren, or C.-I. Wu. Please send by9 April 1990 curriculum vitae, a letter detailing teachingexperence and/or areas of expertise, research interests,and the names of three referees to: Barry G . Hall,Department of Biology, Hutchison Hail, Universityof Rochester, Rochester, NY 14627. The University ofRochester is an Equal Opportunity/Afirmative Action Em-ployer.

EXTENSION AGRICULTURAL ENGINEERASSISTANT PROFESSOREXTENSION/RESEARCHDEPARTMENT OF

AGRICULTURAL ENGINEERINGUNIVERSITY OF MINNESOTA

The Department of Agricultural Engineering, Univer-sity of Minnesota, is seeking candidates for an assistantprofessor, extension/research (12-month, tenure-track)position. Responsibilities include leadership and coordi-nation ofprograms in livestock housing (pnmarily dairy)education for the Minnesota Extension Service. Thisposition will include an applied research component.Required: Ph.D. in agricultural engineering or relatedengmeering field at date ofappointment. Desired: educa-tion in some of the following areas related to livestockhousing: environmental control of livestock systems,waste collection and storage, structural design and build-ing material selection, farmstead layout, reed handlingand milking systems, neutral-to-ground voltage, animalcomfort and behavior, and safety of people and animals.Demonstrated effective teaching, speaking, and writingskills. Experience in livestock housing and extensioneducation. Send letter of application, including curricu-lum vitae; a one-page summary of career goals in thecontext of the position; college transcripts; and names,addresses, and telephone numbers of three professionalreferences by 30 Aeril 1990 to: Dr. G. R. Foster,Department of Agricultural Engineerng, Universityof Minnesota, St. Paul, MN 55108.

The University of Minnesota is an Equal OpportunityEducator and Employer and specifically invites and encouragesapplications from women and minorities.

SCIENCE, VOL. 247

POSITIONS OPEN POSITIONS OPEN

ImmuLogic is a growing company with laboratoriesin Cambridge, Massachusetts and Palo Alto,

California, dedicated to the creation of novel therapeutic and diagnostic products tomodulate and monitor the human immune system. We employ state-of-the-art tech-niques and proprietary knowledge in immunology, biochemistry and molecularbiology to develop products in the vaccine, allergy and autoimmune disease areas.We collaborate with world leaders in the pharmaceutical industry and in academicinstitutions and are already recognized as a leading force among companies focusingin immunology. We are currently adding to the outstanding scientific team at ourresearch facility in Palo Alto, California.

IMMUNOLOGIST FORAUTOIMMUNE DISEASESRESEARCHWill investigate cellular immune responsesassociated with autoimmune disorders concen-trating on the isolation and study of T cellpopulations involved in specific diseases.Strong background in cellular immunology isrequired, preferably with experience in thehuman T cell area. Interest in study of theconsequences of T cell activation (e.g., cytokineprofile) will be advantageous. 2-6 years'postdoctoral experience with strong record ofachievement is required.BIOCHEMIST FORAUTOIMMUNE DISEASESRESEARCHWill investigate fhe interaction between HLAproteins and antigenic peptides and developassay systems to monitor this interaction andinvestigate the structural requirements for binding.Biochemistry/Chemistry background andresearch experience with cell surface receptorsand/or ligand binding desired. Understandingof relationship between protein structure andfunction and 2-6 years' postdoctoral experiencewith strong record of achievement is required.CHEMIST FORAUTOIMMUNE DISEASESRESEARCHWill investigate the structural requirements forHLA protein-antigenic peptide binding via thesynthesis/design of peptides and peptidomimeticdrugs which interact with HLA proteins. Involvesboth peptide and medicinal chemistry techniques.Requires experience with computer-assisteddrug design/molecular modeling technologies.Medicinal chemistry background, includingexperience with peptide synthesis/design, and2-6 years' postdoctoral experience with strongrecord of achievement also required.

RESEARCH ASSISTANTSIASSOCIATES IN PEPTIDE/PROTEIN CHEMISTRYIndividuals with experience in peptide synthesisand design, protein purification or ligandbinding assays are required for several positions.A minimum of a Bachelor's degree plus twoyears of relevant laboratory experience arerequired, although more senior individuals are

strongly encouraged to apply. These positionsoffer strong career opportunities with growingindependence and responsibility for well-trained and experienced scientists.

ImmuLogic provides an outstandingworking environment and state-of-the-artlaboratory facilities. We have a first-rate support network of academicadvisors and collaborators, an activepostdoctoral program, and we supportand encourage the publication ofimportant research findings. ImmuLogicoffers competitive salaries and benefitsas well as equity participation throughan incentive stock option program.

Please send curriculum vitae and list of publica-tions to: ImmuLogic PharmaceuticalCorporation, 855 California Avenue,Palo Alto, California 94304, ATTN:Human Resources Department.

IMMULOGICPharmaceutical Corporotion

Equal Opportunity Employer.

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00r,

Bone PhysiologistSyntex eamed its worldwide reputation as a superior,forward-looking health care and pharmaceutical companythrough years of applied research and progressivedevel-opment. As we continue to grow, we offerthe followingoutstanding opportunityfor a motivated staff-level scientistat our San Francisco Bay Area research headquarters.The ideal candidate will be responsible for designingand conducting in vivo models of osteoporosis and bonedegradative disease to support on-going and plannedsynthetic peptide programs. This would involve super-vising technical staff. You will also conduct basic studiesto explore the endogenous mediators of bone growth/resorption.Requirements include a PhD in Physiology or equivalent,and 4+ years of full-time post PhD research. Experiencewith techniques of bone assessment such as histomorpho-metry are necessary. Dual photon densitometry experi-ence is desirable.Syntex offers a competitive salary and benefits package ina pleasant campus environment. For immediate consid-eration, please send your resume to: Syntex, ProfessionalStaffing, Dept. KH/SM-R, 3401 Hiliview Avenue, PaloAlto, CA 94304. Syntex is an equal opportunity employer.

- I=NT

Research MicrobiologistBiochemist

An opening is available in the Microbial Physiology Depart-ment of the Infectious Disease Research Section at LederleLaboratories for a Research Microbiologist/Biochemist with aPh.D. and 2-5 years' postdoctoral experience.

The successful candidate will join an exciting multidisciplinarygroup involved in the search for novel bioactive natural pro-ducts. The ideal candidate should have a thorough educationand training in microbial physiology and biochemistry withexperience in intermediary metabolism and/or biosynthesisof secondary metabolites. Research will involve microbialfermentation exploiting current technology to generate newbiosynthetic products with pharmaceutical application.

Lederle Laboratories is located on a 580-acre campus inRockland County, which is 25 miles north of New York City.We offer a competitive starting salary and excellent benefits.For immediate consideration, send your resume with salaryrequirements to: Professional Employment Office, Dept. MG.,Lederle Laboratories, N. Middletown Road, Pearl River, NY10965. An Equal Opportunity Employer m/f.

POSITION AVAILABLEDIRECTOR, MEDICATIONS DEVELOPMENT DIVISION

NATIONAL INSTITUTE ON DRUG ABUSEALCOHOL, DRUG ABUSE, AND MENTAL HEALTH ADMINISTRATION

PUBLIC HEALTH SERVICEDEPARTMENT OF HEALTH AND HUMAN SERVICES

The Alcohol, Drug Abuse, and Mental Health Administration invites nominations and applications for the position of Director, MedicationsDevelopment Division, National Institute on Drug Abuse.This is a Senior Executive Service position in the career civil service, with an annual salary range of $71,200 to $79,200. Physicians mayalso be eligible for a Physicians' Comparability Allowance of up to $20,000 per year. The position is located in Rockville, Maryland.The Director, Medications Development Division provides programmatic, administrative, and general management of the five branches of theDivision: the Biometrics Research Branch, the Clinical Trials Branch, the Regulatory Affairs Branch, the Chemistry and Pharmaceutics ResearchBranch, and the Pharmacology and Toxicology Branch. The Director is also responsible for coordinating the activities and medications developmentrequirements of the three ADAMHA Institutes into the scientific and management activities of the Division and maintains close contact withdesignated medications development staff at the National Institute on Alcoholism and Alcohol Abuse and the National Institute of Mental Health.The Director is also responsible for maintaining close working relationships with senior staff at the Food and Drug Administration on mattersrelating to operational and scientific procedures involved in medications development as well as the development of policy affecting ADAMHA'sprograms. Additionally, the Director provides authoritative advice and consultation to senior agency officials on a wide range of matters pertainingto the treatment of brain and behavior disorders and the pharmacological evaluation of new treatment agents.Minimum qualifications requirements include a degree of Doctor of Medicine, Doctor of Osteopathy, or a bachelor's degree or higher degreein an academic field related to the health sciences pertinent to the work of the position. Candidates must demonstrate evidence of progressivelyresponsible experience in managing large, complex science/research programs in the biomedical/behavioral areas; supervising or collaboratingwith senior-level scientists in academia, private industry, or the Federal Government; extensive current knowledge of research methodologyin the biomedical, behavioral, pharmacological, or clinical sciences in areas relevant to drug abuse.Further information about the position and qualifications requirements may be obtained by contacting Ms. Leslie Everheart at (301) 443-5030.An SF 171 (Application for Federal Employment) accompanied by a current curriculum vitae and bibliography should be submitted to Ms.Everheart at the Division of Personnel Management, Alcohol, Drug Abuse, and Mental Health Administration, 5600 Fishers Lane, Room 15C-26,Rockville, Maryland 20857. Complete Application material (including the SF 171) must be postmarked by the closing date of April 30, 1990.Resumes are not acceptable for entrance into the Senior Executive Service.Applications from women and minority group members are encouraged.

THE ALCOHOL, DRUG ABUSE, AND MENTAL HEALTH ADMINISTRATION IS AN EQUAL OPPORTUNITY EMPLOYER

In our NMR - labs at the Central Research Units ofHoffmann - La Roche & Co., Ltd., at Basel, Switzerland, apermanent position is available for an

NMR expert_

A suitable candidate should have state of the art training inhigh resolution 2D NMR and preferably also some experiencein working with macromolecules. The successful applicantwill have the opportunity to work on a Bruker AM 500spectrometer and to engage in computer assisted molecularmodeling. The major activities are the structural elucidationof bio-macromolecules and the further developmenVimple-mentation of novel multipulse NMR technology. The scien-tific environment offers collaboration possibilities with thegroups for X-ray Crystallography, Biophysics, MolecularModeling and Molecular Biology.

Interested candidates are invited to send their applicationwith a curriculum vitae to our Personnel Department quotingreference Science 19/90/WA.

F. Hoffmann-La Roche Ltd, CH-4002 Basle

OHIO5/i0su PRESIDENTrThe Board of Trustees of The Ohio State University

invites nominations and applications for the position ofPresident.

The University seeks a President who can lead ittoward its goal of enhancing its position as a preeminentpublic university with land-grant missions of research,teaching, and service. The President must be able toprovide innovative and creative leadership in the devel-opment and implementation of a strategic plan for theUniversity and to communicate this vision persuasivelyto the University community, government leaders, andthe people of Ohio and the nation.

The President of the University must hold an earneddoctorate or its equivalent, be respected by the academiccommunity as a nationally recognized leader, and haveanoutstanding record of scholarly achievement. The suc-cessfulcandidate mustbe cognizant ofand sensitive to theaspirations and interests of all members of a multiculturaluniversity community and be dedicated to, and prefera-bly have a record of achievement in, an effective programfor affirmative action. The President must be able todelegate responsibility and to work effectively with astrong and vital system of shared governance. She or heshould foster an environment in which students, scholars,staff, and administrators of distinction can be attracted tothe University. In addition, the President must be able toestablish and promote favorable relationships with otherconstituencies including alumni, business, industry, andgovernment. Above all, the President must exhibit thehighest standards of intellectual, personal, and profes-sional integrity.

TheOhio State University is a comprehensive and di-verse academic institution with more than 58,000 stu-dents, 4,000 faculty, 10,000 staff members, and an operat-ing budget in excess of one billion dollars. It is committedto its land-grant tradition and to excellence in all of its en-deavors. The University provides instruction at under-graduate, graduate, and professional levels and reachesout to the broader community through its colleges, com-prehensive medical complex, multidisciplinary researchcenters and institutes, and extension services.

The University is committed to a forceful affirmativeaction plan for faculty, staff, and students; is implement-ing a campus-wide undergraduate curriculum revisionemphasizing a strong general education component; andis completing a highly successful fundraising campaign.

In sum, The University will select a decisive and vig-orous individual to lead The Ohio State University intothe era of global interdependence. The Search Committeewill begin the screening of candidates on April 2,1990,although nominations and expressions of interest willcontinue to be received until the position is filled. Pleasesend nominations and application materials to:

The Ohio State University Presidential SearchWilliam J. Bowen

Heidrick and Struggles, Inc.125 South Wacker Drive

Suite 2800Chicago, IL 60606-4590

The Ohio State University is an Equal Opportunity,Affirmative Action Employer.

Dean of the College of MedicineState University of New York

Health Science Center at BrooklynThe Health Science Center at Brooklyn (formerly Down-

state Medical Center) is seeking nominations and applicationsfor the position of Dean of the College of Medicine. The Deanhas the primary responsibility for the direction and developmentof the College's academic programs, for the development of itsfaculty resources, and for the maintenance ofstandards ofexcel-lence in research, teaching, and service.

The College of Medicine has a full time faculty of 460and a student body of approximately 870 medical students and750 residents and fellows. The faculty maintains an activeresearch program which is supported by growing external fund-ing. The financial resources available to the Center, the Collegeof Medicine, and its faculty, exceed $200 million.

The College is located on the Health Science Center cam-pus in central Brooklyn, in close proximity to the Center's 372-bed teaching hospital, the University Hospital of Brooklyn, andto Kings County Hospital Center, New York City's largest publichospital. The College also maintains major affiations withseven local voluntary teaching hospitals. The Health ScienceCenter has embarked on a major capital program, with a newHealth Science Education Building scheduled to open next yearand a multi-year program for a complete renovation of facultylaboratories and offices about to begin,

The College seeks a dynamic and visionary academicleader with a commitment to excellence in education, research,and patient care. Candidates must possess an M.D. or Ph.D. andbe qualified for the rank of Professor, and should have a recordof significant accomplishment in scholarly activity and aca-demic administration.

Applications and nominations should include a cur-riculum vitae and at least three references, and may be submittedfor confidential review by the Search Committee to: Eugene B.Feigelson, BED., Professor and Chairman, Department ofPsychiatry, Chair, Search Committee, Box #1203, SUNYHealth Science Center at Brooklyn, 450 Clarkson Avenue,Brooklyn, New York 11203.

State University of New YorkI HEALTH SCIENCE CENTER AT BROOKLYN

EO/AA Employer DMC#CO320

;I1-

POSITIONS OPEN

ADMINISTRATIVE OFFICER. The DepartmentofChemistry at Washington University in St. Louis seeksan experienced individual for a major administrativeposition with fiscal planning and oversight responsibil-ities, management of a 26-member support staff, andadministrative support of undergraduate and graduateprograms. Demonstrated administrative skills essential.Advanced degree in chemistry or related area required,doctorate preferred. Women and minority candidates areencouraged to apply. Send resume and have three letters ofreference sent directly to: Professor Joseph J. H. Acker-man, Chair, Department of Chemistry, Campus Box1134, Washington University, One Brookings Drive,St. Louis, MO 63130-4899.

Applications should be received by 16 April 1990 toensure full consideration. Washington University is an EqualOpportunity/Afinnative Action Employer. Employment Eligi-bility Verification required upon hire.

MACARTHUR FOUNDATIONPROGRAM OFFICER. The MacArthur Founda-

tion invites applications for the position of programofficer in its ealth program. The program supportscollaborative research on mental health and human devel-opment and activities which strengthen the policy pro-cess, facilitate knowledge dissemination, and foster col-laboration. A program officer participates in the plan-ning, development, and oversight of all program activi-ties. Applicants must have a doctorate (Ph.D., M.D.), 10years of professional experience, and a track record ofresearch related to mental health and/or human develop-ment. Selection criteria include breadth of knowledgeand perspective, interest in the application of researchresults, and demonstrated capacity to work collaborative-ly. Telephone inquiries will not be accepted. Applicantsshould send curriculum vitae and letter of interest by 27March 1990 to: Coordinator, Search Committee,Hcalth Program, MacArthur Foundation, 140 SouthDearborn Street, Suite 700, Chicago, IL 60603.

TheJohn D. and Catherine T. MacArthur Foundation is anEqual Opportunity Employer.

TENURE-TRACK FACULTY POSITIONCOASTAL PLANT ECOLOGIST

Tenure-track position in coastal plant ecology forASSOCIATE PROFESSOR/PROFESSOR begin-ning fall of 1990, pending final approval. Experience invegetation at the land-sea margin (estuaries, marine-influenced wetlands) and a history of successful interdis-ciplinary collaboration in heterogeneous and landscape-scale systems is desirable. Candidates should have pnorteaching experience, nationally recognized research, andsuccess generating grants and contracts. Teaching re-sponsibilities include a graduate level course in theirspeciality and another in coastal management issues. Willwork cooperatively with 15 other faculty with interests incoastal ecology, looded soils, fisheries, and biologicaloceanography. The appointment will be joint with theCoastal Ecology Institute. Salary commensurate withnational standards for rank and experience. Applicationsshould be received by 15 April 1990, but will remainopen until suitable candidate is found. Submit applica-tion letter, names of three references, resume, and copiesof five recent reprints to: RI Eugene Turner, Chair-man, Department of Marine Sciences, Center forWetand Resources, Louisiana State University(LSU), Baton Rouge, LA 70803. LSU is an EqualOpportunity Employer.

JUNIOR FACULTY POSITIONMATERIALS DEPARTMENT

UNIVERSITY OF CALIFORNIASANTA BARBARA

MACROMOLECULAR MATERIALSA tenure-track position is offered in the general area of

the science and engineenng ofmacromolecular materials.A Ph.D. or equivalent degree, along with a strongbackground in the physics and/or chemistry of polymers,surfactants, or colloids is required. Applications shouldbe received before 1 May 1990 and addressed to:Professor Philip Pincus, Head of Search Committee

Materials DepartmentEngineer II, Boom 1361

University of California, Santa BarbaraSanta Barbara, CA 93106

The University of Califomia is an Equal Opportunity/Affirmative Action Employer. Proof of U.S. citizenship oreligibility for U.S. employment will be required prior toemployment (Immigration Reform and Control Act of 1986).

BIOLOGY FACULTY POSITIONSFROSTBURG STATE UNIVERSITY (FSU)* BOTANIST. One-year, full-time, contractual posi-

tion (without benefits). Teach two plant morphologycourses (covering algae, fungi, bryophytes, vascularplants) and introductory biology course, coordinate in-troductory labs, including weekly meetings, and super-vise graduate assistants. Ph.D. and evidence of ability tosupervise graduate student teaching in laboratories pre-ferred. Inquiries to: Dr. James Perry, 301-689-4173.* PLANT TAXONOMIST. Full-time, tenure-track,

assistant professor (pending expected vacancy). Teachplant taxonomy, denology, and participate in introduc-tory biology. Ph.D. and knowledge of eastern NorthAmerican flora required. Knowledge of tropical floradesirable. Broad background in botany preferred. Re-search encouraged. Inquiries to: Dr. Wayne Yoder, 301-689-4177.* VERTEBRATE BIOLOGIST. Full-time, tenure-

track, assistant professor. Teach courses in ornithology,wildlife techniques, and general ecology. May participatein other vertebrate zoology courses. Ph.D. required.Participation in International Institute for RenewableNatural Resources (emphasis southern Africa/CentralAmerica) desirable. Research encouraged. Broad trainingin vertebrate zoology preferred. Inquiries to: Dr. RonBarry, 301-689-4167.FSU is part of the University of Maryland System and

offers B.S. and M.S. in biology, wildlife, and fisheriesmanagement for approximately 250 majors; new M.S. inconservation biology is being developed.For each position above, send letter of interest, curric-

ulum vitae, graduate and undergraduate transcripts, andnames, addresses, and telephone numbers of three refer-ences by 23 March 1990 to: Mr. C. Douglas Schmidt,Director of Personnel Services, Frostburg State Uni-versity, Frostburg, MD 21532. Afirmative Action/EqualOpportunity Employer.

FACULTY POSITION. Available immediately. Ap-plications are sought for an ASSISTANT PROFES-SOR to join a research program in one of the followingNK cell areas; cellular receptors and stimulus/transduc-tion mechanisms, regulation by cytokines, ontogenicdevelopment. Applicants must have a demonstrated abili-ty to conduct high-quality research and have at least 3years of experience. Curriculum vitae, bibliography, andthe names of three references should be sent to: Chief,Section ofNatural Immunity, Box 18, The Universityof Texas, M. D. Anderson Cancer Center, 1515Holcombe Boulevard, Houston, TX 77030. We are anEqual Opportunity/Afirmative Action Employer.

FACULTY POSITION, PHARMACOLOGYAND TOXICOLOGY. The Department ofPharmacol-ogv and Toxicology at the University of MississippiMedical Center invites applicants for a tenure-track posi-tion as ASSISTANT OR ASSOCIATE PROFES-SOR in pharmacology and toxicology. A Ph.D. or M.D.with postdoctoral research experience is required. Thesuccessful candidate will be expected to develop or havean independent, competitively funded research program.Applicants with experience in all areas of pharmacolo$yand/or toxicology are urged to apply; however, specialconsideration wi be given to those with experience inone of the following areas: drug metabolism (molecularbiology), renal pharnacology/toxicology, teratology,morphology/immuno-histochemistry, and endocrnepharmacology. Applications including curriculum vitae,outline of future research plans, and the names andaddresses of three references should be sent to: Dr. I. K.Ho, Professor and Chairnan, Department of Phar-macology and Toxicology, University of MississippiMedical Center, 2500 North State Street, Jackson,MS 39216-4505. The University of Mississippi MedicalCenter is an Equal Opportunity Employer, M/F/H/V.

GENETICISTWabash College, a private liberal arts college for men,

invites applications for a one-semester position in genet-ics. Teaching responsibilities include team-teaching asophomore genetics course and a seminar course in anarea of the candidate's choice. Applicants who havecompleted the Ph.D. or Ph.D. candidtes will be consid-ered. Salary is competitive. Applicants should submit aresume and three letters of recommemdation to: DavidT. Krohne, Department of Biology, Wabash College,Crawfordsville, IN 47933 by 23 March 1990. Womenand minorities are especially encouraged to apply. WabashCollege is an Equal Opportunity Employer.

BIOCHEMISTRY/MOLECULAR BIOLOGYMEHARRY MEDICAL COLLEGE

FACULTYPOSMONS are available in 1990 in theDepartment of Biochemistry at the level of assistant orassociate professor for well-trained or experienced candi-dates in the following areas: (i) molecular biology ofeukaryotic systems, (ii) membrane biochemistry or mo-lecular biology ofsignal transduction, and (iii) regulatoryaspects of cellular and/or metabolic biochemistry. Suc-cessful applicants will be expected to develop and/ormaintain a funded research program of high quality, toparticipate in the graduate and professional (medical,dental, and allied health) school teaching programs oftheDepartment, and to interact with institutional programsin neuroscience and cell/molecular biology. Applicantsshould send curriculum vitae, names of four individualswho may be contacted for reference, and a summary ofpotential research projects to: Ifeanyi J. Arinze, Ph.D.,Chairnan, Department of Biochemistry, MeharryMedical College, Nashville, TN 37208. Meharry Medi-cal College is an Equal Opportunity/Afirmative Action Em-ployer.

FACULTY POSMONSSECTION OF IMMUNOBIOLOGY

YALE UNIVERSITYThe Section of Immunobiology is building a multidis-

ciplinary group working on basic problems in immuno-biology and seeks applicants for several faculty positionsat the level of ASSISTANT PROFESSOR Qualifiedapplicants in all areas of mammalian gene expression andsignal transduction are invited to apply. We are particu-larly interested in candidates in the areas oftranscription-al regulation and transmembrane signal transduction.Candidates would be expected to develop an indepen-dent research program and to participate in departmentalteaching. Candidates should submit curriculum vitaewith a summary of present and future research interests,and request that three letters ofrecommendation be sent.Applications should be received at the address below nolater than 15 April 1990.

Dr. Richard FlavellChairman, Section of ImmunobiologyYale University School of Medicine

310 Cedar Street, 424 FMBP.O. Box 3333

New Haven, CT 06510An Equal Opportunity/Affirmative Action Employer.Women and minority candidates are encouraged to apply.

FACULTY POSITION IN PHARMACOLOGYUNIVERSITY OF CALIFORNIA, IRVINEApplications are invited for a tenured or tenure-track

position in pharmacology. Qualifications include an out-standing record of research accomplishment in an area ofpharmacology with long-term growth potential, com-mitment to teaching, and a Ph.D. (or M.D., or both) inpharmacology or related field. Level of appointment andsalary will be commensurate with achievement and expe-rience. Curriculum vitae, references, and a summnary ofresearch interests should be sent by 30 April 1990 to:Dr. Larry Stein, Chairman, Department of Pharma-cology, College ofMedicine, Umversity ofCalifornia,Irvine, CA 92717. An Afirmative Action/Equal Opportu-nity Employer.

A JUNIOR FACULTY POSITION is available inthe Oncology Division of the Beth Israel Hospital,Harvard Medical School, to work on a program studyingthe mechanism of genetic instability m neoplasia. Thespecific project is to construct genetically modified vec-tors that are transcriptionally inert, and insert thesevectors into appropriate test systems in which the report-ed genes are activated by DNA rearrangements.The successful candidate must have a Ph.D. degree and

have a minimum of 2 years of pre- or postdoctoralexperience in the molecular analysis of neoplastic cells.He/she must have strong self-motsvation andhave shownthe capability ofdeveloping new techniques and/or assaysystems as documented by thesis research and/or publica-tions in peer-reviewed scientific journals.

Salary: $30,000 per annum. Interested applicantsshould send two copies of resumes to: MassachusettsDepartment of Employment and Training, SpecialPrograms, 19 Staniford Street, Boston, MA 02114and refer to Job Order #00284. Women and minorityapplicants are encouraged to apply; hospital is an Equal Oppor-tunity Employer.

SCIENCE, VOL. 247I252

POSITIONS OPEN POSITIONS OPEN

Postdoctoral Research FellowshipsThe Parke-Davis Pharmaceutical Research Division of Wamer- Applicants should have a Ph.D. in Organic or Medicinal ChemisLambert has initiated a multidisciplinary postdoctoral research pro- or related discipline, with a strong synthetic background. Expgram which will provide excellent opportunities to conduct basic ence with molecular modeling techniques is desirable, but not i

studies in areas of potential therapeutic utility. The following Fellow- sential.ships are currently available: Fellowship K

Fellwshi FelwsiFellowshi p F Neurophysiology of Dopaminergic SystemsNeurotransmiffer Release and/or Using extracellular and intracellular electrophysiological recordElctrphysiology of Dopamine Systems techniques in both whole animals and in in-vitro brain slices,The Fellow will be appointed within the Neurosciences Section to Fellow will investigate the effects of dopamine and dopamine;investigate the neurochemistry/physiology of dopaminergic neuro- onists on indices of dopamine autoreceptor and dopamine pctransmission. Autoreceptor and peptide regulation of transmission synaptic receptor function.is of' major interest, but the Fellow will be given wide latitude in Applicants should have a Ph.D. in a Neuroscience related areaachoosing research activities and methodological approaches. experience with electrophysiological techniques.Candidates will be trained as necessary but should have a Ph.D Fwith background in one or more of the following: electrophysiology; Fellowship LHPLC, in-vitro release, microdialysis or in-vivo voftammetry. Regulatin of Oxygen Radical Production

Fellowship G This Fellow will work in the Immunopathology Department invitigating the regulation of oxygen radical production by phagoc)Endothelin Biology/Cardiovascular Biochemisry cells. Research will involve biochemical characterization of sigThe Fellow will work in the Cellular and Molecular Group of the Car- transduction processes required for this response.diovascular Section. This project will involve assessment of cellular/ Applicants should have a Ph.D. in Biochemistry, Cell Biology ormolecular mechanisms underlying the cardiovascular physiology of ative field. Relevant experience is desirable.endothelin. Regulation of endothelin processing in various tissuesin normal and pathological models will be explored using conven- Fellowship Mtional (e.g., protein/enzyme purification) and/or molecular tech-niques (e.g., gene expression). Lymphocyte Subpopubaon Functons In-VroApplicants should have a Ph.D. in Pharmacology, Physiology or Bi- The Fellow will work in the Immunopathology Section of the Iochemistry with extensive experience in one or more of the follow- partment of Experimental Therapy. The project is designed toing: prohormone processing, post-translational modification of pep- plore the immunological basis for immune deficiency associatides, protein/enzyme purification and characterization, enzyme/re- with the congenital deficit in the enzyme purne nucleoside phceptor systems, recombinant DNA technologies and tissue culture. phorylase (PNP). The fellow will study the effects of PNP inhibitceptr sytem, reombiantDNA echnlogesad tisuecuftre.

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Fellowship HAtherosderosis PharnacologyThe Fellow will work in Atherosclerosis Pharmacology to study therole of fatty acid binding protein on the synthesis and secretion oftriglyceride-rich lipoproteins. The studies will focus on modulabtionof expression of hepatic FABP in transfected cells. The successfulcandidate will possess a Ph.D. in Biochemistry, Cell Biology, Mo-lecular Biology or a relevant field. Experience in fatty acid metab-olism, protein isolation or lipoprotein synthesis is required. A knowl-edge of molecular techniques would be an added advantage.

Fellowship ISyntesis and Sbt ure-Actvty Relaionships ofSigma UgandsSee description for Fellowship J

Fellowship JExploraon of the NMDA Receptor Complex throughMolecular Modeling and the Synthesis ofSite-Directed AntagonistsTwo fellowships in CNS chemistry are immediately available. Usingexisting computer assisted molecular models of the aforementionedreceptor sites, the Fellow will design and synthesize specific ligandsas potential CNS agents. An important objective of this research isto enhance the sophistication of the current molecular models tobetter define the receptors of interest. Biological screens are inplace for rapid feedback of in-vitro and in-vivo activity.

PARKE-

Ull FllbtUWll1zl1IUliltY tSIItI9Ull fdAPFIWb1VII,16_YLUbUr1V P1UUUk;UU1, tiliuother functional aspects of human and/or murine lymphocyte sub-populations.Applicants should have a Ph.D. in Immunology and experienceworking with separated lymphocyte subpopulations.

Fellowship NCaplary HPLC, Capiary Electphoresis/Mass SpectrometryUsing mass spectrometric detection, the Fellow will implementmodern capillary separation methods (capillary electrophoresis,capillary HPLC). These techniques will be applied to basic neuro-science investigations and to the characterization of synthetic pep-tides and biosynthetic products.Applicants should have Ph.D. in Analytical or Bioanalytical Chem-istry and experience in HPLC/MS. A background in capillary elec-trophoresis or microdialysis would be helpful.

All appointments are for one year, renewable for a second year.Compensation includes $32,000 annual salary with relocation ex-penses and an attractive benefits package. Our modern researchfacilities are located adjacent to the University of Michigan in an out-standing living and working environment.Send letter of application with curriculum vitae and names of threereferences to Jack Moyer, Human Resources, Parke-DavisResearch Division, Warner-Lambert Company, 2800 PlymouthRoad, Ann Arbor, Ml 48105. Please indicate the Fellowship youare applying for. "Smoke-Free Work Environment".

DAVlIS "Equal Opportunity In Action"

A DIVISION OF WAIWUE/

LAAWEI8

I

POSITIONS OPEN

MEDICAL FACULTY POSMONSSix new positions: PROFESSOR OF MICROBI-

OLOGY, ASSISTANT/ASSOCIATE PROFESSOROF PHARMACOLOGY, ASSISTANT/ASSO-CIATE PROFESSOROF PHYSIOLOGY, ASSIST-ANT/ASSOCIATE PROFESSOR OF PATHOLO-GY, SENIOR RESEARCH SCIENTIST, andANATOMY. All except the research scientist are tenuretrack. The microbiology position is for a medical parasi-tologist. The anatomy position is for any r andrequires at least 2 years of teaching experience in grossanatomy or neuroanatomy with preference for candidateswith research in the areas of ultrastructural histochemis-try, cell-extracellular interactions, or neural development.Thc pharrnacology and physiology positions requlrepostdoctoral experience with preference for candidateswith medical school teaching and research experience.The pathology position includes general, systemic, andclinical pathology lectures and direction of clinical labo-ratory with preference for strong background in clinicalpathology. The research scientist position is for a bio-chemical endocrinologist who can run a clinical diagnos-tic laboratory. Send resumr and names of three referencesto: Robert Ritter, Ph.D., Associate Dean for BasicSciences, College ofOsteopathic Medicinc ofOklaho-ma State University (COM-OSU), 1111 West 17th,Tulsa, OK 74107-1898. Positions will be filled on orafter 1 July 1990. Application deadline is 15 April 1990,except for anatomy and pathology, which are 15 May1990. Please specify which position you are applying for.COM-OSU is an Equal Opportunity/Afirmative ActionEmployer.

FACULTY APPOINTMENTYALE UNIVERSITY

SCHOOL OF MEDICINEThe Department of Anesthesiology invites applica-

tions from Ph.D. or M.D. candidates for an appointmentat the ASSISTANT OR ASSOCIATE PROFESSORlevel. Suitably qualified candidates will be eligible for ajoint appointment in the Department of Pharmacology,and will be encouraged to develop association with thecardiobiology program of the Yale Center for MolecularMedicine.

Candidates should have specific training in biochemi-cal,pharmacology and/or molecular biology as applied tothe vascular system. Demonstrated interest m signaltransduction mechanisms in the vessel wall or cell-cellcommunication will be particularly attractive.

Send applications by 15 April 1990 with statement ofinterests to: C. Norman Gillis, Ph.D., Professor ofAnesthesiology and Pharmacology, Yale UniversitySchool of Medicne, 333 Cedar Street, New Haven,CT 06510.

Yale University is an Affirmative Action Employer andprovides Equal Opportunities to all applicants.

RESEARCH FACULTY MEMBERThe Department of Biological Chemistry at the Uni-

versity of Texas Health Science Center at Houston,Dental Branch, has an opening for a research facultymember (nontenure track) at the INSTRUCTOR orASSISTANT PROFESSOR level. Duties involve col-laborative research on the protein chemistry and/or mo-lecular biology of bone proteins. A Ph.D. or a relatedfield and 2 years of postdoctoral experience in biochemis-try are required. Additional qualifications such as abackgrod in protein characterization and recombinantDNA research are helpful. Send curriculum vitae andnames and addresses of three references to: Dr. WilliamT. Butler, Chairman, Department of BiologicalChemistry, University of Tcxas Dcntal Branch, P.O.Box 20068, Houston, TX 77225. The University ofTexas Health Science Center at Houston is an Equal Opportu-nity Employer. Women and minorities are encouraged to apply.

HISTOLOGY/ELECTRON MICROSCOPY. Im-mediate opening for histology technician with skills inelectron microscopy in a neuroendocrinology laboratory.Responsibilities include assisting with stereotaxic sur-gery, perfusing specimens, and running immunocy-tochemistry for localization of hypothalamic peptides.Experience in transmission electron microscopy withexpertise in thin sectioning required. Training in immu-nocytochemistry will be provided. Please contact: IleneGranstein, Human Resources, Tufts University, 200Harrison Avenue, Boston, MA 02111. Telphone:617-956-6600. Affirmative Action/Equal OpportunityEmployer.

1254

MOLECULAR BIOLOGISTGYNECOLOGIC ONCOLOGY/CMS BIOLOGY

NORTHWESTERN UNIVERSITYMEDICAL SCHOOL

Applications are invited for a tenure-track facultyposition at the ASSISTANT PROFESSOR level withprimary appointment in the Section of GynecologicOncology within the Department of Obstetrics andGynecology (OB/GYN) and secondary appointment inthe Department of Cell, Molecular, and Structural(CMS) Biology at the Northwestern University MedicalSchool. Applicants should have a Ph.D. degree andpostdoctoral training in molecular biology relating to thestudy ofmalignant diseases. We are seeking an individualwho will develop an independent, basic molecular biolo-gy research program in gynecologic oncology, collabo-rate with other members of the Department ofOB/GYNand CMS Biology and the cancer center on projectsinvestigating human malignancy, and participate in med-ical student and graduate teaching programs of bothdepartments.

Applicants should send curriculum vitae, a brief de-scnption of previous and future research and teachinginterests, reprints of significant published work or pre-prints of manuscripts in press, and at least three letters ofrecommendation to: John R. Lurain, M.D., Head,Section of Gynecologic Oncology, Department ofObstetrics and Gynecology, Northwestern UniversityMedical School, 333 East Superior Street, Chicago,IL 60611.

Northwestern University is an Equal Opportunity/Afirma-tive Acion Employer and invites applicationsfrom all qualifiedindividuals.

MOLECULAR GENETICS POSMONS. Anopening is available in our Animal Biology ResearchCenter in Athens, Ohio, for a molecular geneticist experi-enced in gene construction and mammalian gene expres-sion. Duties include independent research and oversightof a molecular analysis program identifying transgenicanimals. A Ph.D. and postdoctoral training are required.There are also openings for B.S./M.S. level RE-

SEARCH ASSISTANTS experienced in mammaliangene transfer and microinjection technology. Please sendcurriculum vitae and the names of three references to:Dr. Carl A. Pinkert, Director, Animal Biology Re-search Center, DNX, One President Strat, Athens,OH 45701.

MOLECULAR FOREST GENETICIST/BIOL-OGIST. ASSOCIATE/FULL PROFESSOR of mo-lecular genetics/biology, tenure track. Candidates areexpected to establish a research program to supplementmultidisciplinary team focused on using molecar toolsfor improvement of southern pine. The program isexpected to use recombinant DNA and gene transfertechnology to elucidate and manipulate genes of eco-nomic importance. Financial/staff supprt associatedwith position. New plant molecular biology facilityavailable 1993. Ph.D. in biochemistry, forestry, genetics,or related field required. Significant research accomplish-ments and ability to use innovative approaches andtechniques in research, secure extramural funding, andwork with a team are essential. Salary commensuratewith experience. Submit application letter, includingstatement of current research direction, resume, andthree professional references to: Dr. Ronald J. Newton,Chair Search Committee, Department of Forest Sci-ence, Texas A&M University, College Station, TX,77843-2135.

MOLECULAR PARASITOLOGY. Applicationsare invited for an appointment by 1 July 190 in theDivision ofGeographic Medicine, Case Western ReserveUniversity, Cleveland, Ohio, at the level of RE-SEARCH ASSOCIATE with salary dependent onqualifications and prior experience. This position will bepart of a large multi-investigator group studying thepathogenic mechanisms and human host immune re-sponse to the protozoan Entamoeba histolytica with thelong-term goal of developing an efficacious subunitvaccine. A successful candidate will have a Ph.D. or M.D.degree, extensive experience with molecular biologytechniques, and have completed a relevant postdoctoralfellowship. There is an opportunity for a future tenure-track position dependent on performance. Interestedindividuals should send curricuum vitae complete withreferences to: Jonathan I. Ravdin, M.D., Departmentof Medicine, University Hospitals of Cleveland,Cleveland, OH 44106.

NEUROBIOLOGY FACULTY POSITION. TheDepartment of Biological Sciences, University of Mary-land Batlimore County (UMBC), invites applicationsfrom neurobiologists with research interests that employbiochemical/molecular biological approaches to the studyof neural systems. Applicants must have a Ph.D. andpostdoctoral experience. The position is currently openat the ASSISTANT PROFESSOR level, but candi-dates with exceptional qualifications and prior academicexperience will be considered for appointment at a higherrank. We seek individuals capable of developing anindependent research proga and ofcontributing to thedepartment's instructional program, teaching at both theundergraduate and graduate levels. Doctoral degrees areoffered in biological sciences and in molecular and cellbiology. Salaries are competitive, and start-up funds andfacilities are excellent. We are particularly interested incandidates who employ contemporary molecular meth-ods to study physiological aspects of nervous systemfunction. Apphicants should submit curriculum vitae,summary of current and future research interests, andnames, addresses, and telephone numbers of three refer-ences. Applications should7 be submitted by 6 April 1990to: Dr. Phillip G. Sokolove, Chair, NeurobiologySearch Committee, Department of Biological Sci-ences, UMBC, Baltimore, MD 21228. UMBC is anEqual Opportunity Employer.

INVERTEBRATEPHYSIOLOGIST

Harbor Branch Oceanographic Institution (HBOI) isseeking to fill an entry-level position on the residentscientific staffof the Division ofMarine Sciences. Strongpreference will be given to scientists with interests in thecomparative physiology or physiological ecology of ma-rine invertebrates. Applicants should have postdoctoralexperience. HBOI offers unique research opportunitiesusmg its research vessels and Johnson-Sea Link submer-sibles. The chosen candidate is expected to aggressivelypursue external research funding. Send letter outliningresearch background and current research interests, to-gether with curriculum vitae and names of three refer-ences, to: K. J. Eckelbarger, Director, Division ofMarine Sciences, Harbor Branch Oceanographic In-stitution, 5600 Old Dixie Highway, Fort Pierce, FL34946. Application deadline: 1 May 1990. Harbor Branch(Ceanographic Institution is an Equal Opportunity/AfirmativeAcion Employer.

PHYSIOLOGISTASSISTANT OR ASSOCIATE PROFESSOR

Starting during 1990. Requirements: postdoctoral re-search experience in one or more of the following areas,as applied to respiratory physiology and disease: neuro-physiology, growth and adaptation, muscle physiology,or mechanics. Position entails independent research andcollaboration with colleagues studying respiration atlevels from molecular through organ systems to popula-tions as well as teaching and supervision of graduatestudents and postdoctoral fellows. Send curriculum vitae,names of three references, and best one or two publica-tions to: Robert B. Banzett, Ph.D., Department ofEnvironmental Science and Physiology, HarvardSchool of Public Health, 665 Huntington Avenue,Boston, MA 02115. We encourage applicationsfrom womenand minorities.

PHYSIOLOGY AND BIOPHYSICSApplications are invited for two tenure-leading faculty

positions at the ASSISTANTORASSOCIATE PRO-FESSOR levels in the Department of Physiology andBiophysics. These positions will be available 1 July 1990.Research areas ofinterest include endotheial cell-smoothmuscle interactions, cardiovascular ion channels, andmembrane transport. In addition to carrying out anactive research program, the candidate will be expectedto participate in the teaching programs ofthe departmentwhich include graduate, medical and allied health stu-dents. A competitive salary and set-up funds are avail-able. Interested applicants should send current curricu-lum vitae and the names of three references by 30 April1990 to:

Irving H. Zucker, Ph.D., ChairmanDepartment of Physiology and BiophysicsUniversity of Nebraska College of edicine

42nd and Dewey AvenueOmaha, NE 68105

The University of Nebraska is an Equal Opportunity!Affirmative Action Employer.

SCIENCE, VOL. 247

POSITIONS OPENPOSITIONS OPEN

FROM INDIVWUAL STRENGTHSCOME COLLECTIVE SUCCESS.

bromeiad. In a ramfrest, this elegant

epihyt poviesfoodfor insectaxnd "smal

animals nourished by micro-orgniss clletedin the

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that, tgte,Maintain the overall

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mentorganizto-h LW. Johso

Pharmaceuticl Resac histitue (PRI).__The reasonbhind tis initiative is simple.or Johnson & Johnson totinue atewold's health care r t-l r, we mustmake a firm and fo snt in theareas of drug discovery and development.And we're doimg this by pooling the mindsand resources of Ortho Phamacetical Co-poration R&D, CIag I aonal ResarCenter, McNeil Phamutical R&D, OrthoBiotech R&D and Johno & JohnsoBiotecnology Cent.Together, we have the s h and mass tomt the alle Of today's c itiveresearch envronmen And by eng teformidable chal s, we mill establish RI asone of the wrld's lead icalR&D compaies. To do this, we're contin-uallys entryh senior kvel candi-dates t join us at one of our several sites inthe following fields: pharmacy, biology,bichmistry, toxcology, iunogy, chem-istry, microbiology,phamclg, pathoog, staitc, nurinand medicine. Send your resume tao: SeliDept SC-309, RW. Johndo PharmaceudcalResearch nitute P.O. Box 300, Raritan, NJ08869-0602.An Equal Oppornity Employer mi/f.

R.W. IOHNSON

PHARMACEUTICALRESEARCHINSTITUTE

La Jolla ZurichSpring House Raritan Toronto

RESEARCH SCIENTISTCELL BIOLOGY

Amgen has emerged as an industry leader in the discovery and developmentof human therapeutic products through the application of biotechnology. Ourcontinued growth has created an opportunity for a Ph.D. level scientist todevelop programs for the functional analysis of growth factors and receptors.The successful candidate will also participate in collaborative research effortsfor the isolation and expression of novel factors with therapeutic potential.

Candidates for this position must have a Ph.D. in mammalian cellular physiol-ogy or somatic cell genetics and a minimum of 2 years' post-doctoral experi-ence in cellular regulation by extracellular/intracellular factors andtransmembrane signaling mechanisms. Familiarity with cloning, cell sortingand isolation of metabolic and drug resistant mutants in various cell lines isessential. Experience in developing ligand-receptor assays is desirable.

Amgen is committed to maintaining an environment that encourages scien-tific excellence and creativity. We offer an excellent compensation andbenefits package, including equity opportunities. If you share our dedicationto the future of biotechnology and would like to be a part of a company thatplaces a high priority on its human resources, please send a C.V., in confi-dence, to:

AMGEN, INC.Recruitment, Dept. #514Amgen CenterThousand OaksCA 91320-1789

EqualA

Opportunity

Employer

POSITIONS OPEN

POSTDOCTORAL POSITION. To study the mo-lecular mechanism of a virus fusion reaction. Experiencein molecular biology, protein biochemistry, and/or virol-ogv is desirable. Available spring/fall of 1990. Please sendcurriculum vitae and names of three references to: Dr.Margaret Kielian, Department ofCell Biology, AlbertEinstein College of Medicine, 1300 Morris Park Ave-nue, Bronx, NY 10461. An Equal Opportunity Employer.POSTDOCTORAL POSITION. For 2 years in

alcohol research available July 1990. Studies include thehormonal regulation of ethanol metabolism in primaryhepatocyte culture and the effects of ethanol on pyridinedinucleotides and ADP-ribosylation in hepatocytes. U.S.citizen or permanent resident. Send letter of application andcurriculum vitae to: Esteban Mezey, M.D. Professor ofMedicine, The Johns Hopkins University, Hunt. 415,725 North Wolfe Street, Baltimore, MD 21205.POSTDOCTORAL POSMIION. To study the neu-

rophysiology of nucleus accumbens neurons in vivo andin vitro. Projects include regulation of activity by mono-amine receptors and the effects of neuroleptics and drugsof abuse on receptor-mediated responses. Expenence mintracellular or extracellular recording preerable butother qualified candidates will be considered. Salarycompetitive and commensurate with experience. Sendcurriculum vitae and three letters of reference to: Dr.Francis J. VWhite, Department of Psychiatry, WayneState University School ofMedicine, Lafayette Clinic,951 East Lafayette, Detroit, MI 48207. Wayne StateUniversity is an Equal Opportunity/Ajfirmative Action Employer.POSTDOCTORAL POSITION. In woody plant

molecular genetics. Several projects available immediate-ly for individual with molecular genetics background towork with an interdisciplinary team investigating theresponse of Populus genotypes to environmental stresses.Ph.D. and strong background in woody plant molecularbiology required; quantitative genetics and stress physi-ology desirable. U citizen; 2-year appointment; salary:$29,890 per year. Send curriculum vitae and threereferences to: W. J. Rietveld, Forestr Sciences Labo-ratory, East Campus-University of Nebraska at Lin-coln, Lincoln, NEt 68583-0822.

ACTION THEMATIQUE ET INCITATIVESUR PROGRAMME ET EQUIPE (ATIPE)

Call for offers: artificial synthesized RNAs, structure-function andactivity on the expression of the genetic message.

Application deadline (20 copies): March 31st 1990

The aim of the present ATIPE, proposed by the Life Science CNRS Department, in association with other Scientific Departments(Chemistry, Mathematics, Basic Physics, Applied Physics for the Engineer) are mainly to promote new research groups on the abovecited topics.The goals of the long-term actions (at least three years) are the following:1. Help post-doctoral investigators wishing to master the concepts and techniques in the concerned scientific fields, with, at the end

of the program, the real possibility to be recruited by CNRS.

2. Integrate statutary and non statutary investigators in already established laboratories. In order to achieve the selected programs,the host laboratories will receive specific financial and technical support from CNRS.

The present action is not directed at scientific groups working for a long time on the subject. They are well known by CNRS and

already receive or will receive appropriate support.Scientific topics of the program:1. Preparation of synthetic RNAs

- studies of new methodologies to better prepare synthons required for the production of RNA- preparation of modified RNAs.

2. Structural and functional studies of the artificial synthesized RNAs.- secondary and tertiary structures- reactivity- catalytic activity- stability and biodisponibility

3. Modulation of the genetic expression by synthetic antisens RNAs.- replication- splicing- translation- reverse transcription and encapsidation.

Modalities of application:This action is addressed to post-doctoral Investigators with 1-2 years experience already recruited or not by CNRS, willing to acquirea high level training in one of the concerned topics. They must propose a training-schedule and, if selected, will be supported byATIPE. Their cursus will be followed regularly by the Scientific Committee. At the end of the training program, their recruitment byCNRS will be considered prioritary, in concertation with CNRS National Committee.

Candidacies, written in french or english, will be sent under the form of a declaration of intent (brief description of scientific

background and proposed scientific program). Standard application forms will be available at CNRS: Mrs Ariel Gille, PHONE:

33.1.47.53.10.40 and in the applications should be addressed to Mrs Ariel Gille: CNRS, 15, Quai Anatole France, 75700Paris -France).

D6partement des Sciences de la Vie du CNRS15, quai Anatole France. 75700 PARIS-FRANCE

T6l: (1).47.53.15.15

POSTDOCTORALPOSITION

Position available for an individualwith a Ph.D. in cell biology, biochem-istry, or physiology with experience incell culture. The successful applicantwill be involved in research into themolecular mechanisms throughwhich physical forces, generated dur-ing cellular deformation, influencecellular biochemistry. Research willfocus on the molecular structures in-volved in regulation of mechanically-sensitive adenylate cyclase and Na+/H+ antiporter activities during volumeexpansion and compression, as wellas during cell spreading followingextracellular matrix attachment.Competitive salary and fringe benefitsare available. Please send CV andthree names or letters of reference to:

Dr. Peter A. WatsonWeis Center for Research

Gelsinger ClinicDanville, PA 17822

Equal Opportunity Employer M/F/HN

Geisinger

POSITIONS OPEN

POSTDOCTORAL POSMON. Available imme-diately for fibroblast growth factor receptor biochemis-try. Analysis of functional epitopes on FGF-R by mono-clonal antibodies. FGF-R signal transduction. Coronaryangogenesis. Send curriculum vitae and names of threereferences to: M. E. Schelling, Program in Geneticsand Cell Biology, Washington State University(WSU), Pullman, WA 99164 4234. WSU is an EqualOpportunity/Affirmative Action Educator and Employer. Pro-tected group members are encouraged to apply.

POSTDOCTORAL POSMIION. Available imme-diately to study the mechanism(s) ofcytolytic and noncy-tolytic functions, the receptor structure, and ontogeny ofNK cells. Candidates with experience in NK cell areashould send curriculum vitae and the names of threereferences to: Chief, Section of Natural Immunity,Box 18, The University of Texas, M. D. AndersonCancer Center, 1515 Holcombe Boulevard, Hous-ton, TX 77030. We are an Equal Opportunity/AffirmativeAction Employer.

POSTDOCTORAL POSITION. To study electro-physiology ofserotonin receptor activation m vitro in rathippocampal slices. Opportunity to interact with otherdepartmental investigators who use a variety ofbiochem-ical, anatomical, and molecular approaches to studsignal transduction. Experience with mtracellular record-ing desirable. Availabe immecdiately. Contact: Dr. J.Goldfarb, Departent of Pharmacology, Box 1215,The Mount Sinai School ofMedicine, One Gustave L.LIvy Place, New York, NY 10029-6574. An EqualOpportunity Employer.

POSTDOCTORAL POSMONBiochemist/molecular biologist wanted to study the

relation of sphingolipids to myeloid/macrophage devel-opment. The project involves identification of novelsphingolipids and characterization of enzymes involvedin their metabolism. Salary: $30,000. Send curriculumvitae and addresses of two references to: Dr. RichardKolesnick, Mcmorial Sloan-Kettering Cancer Center,1275 York Avenue, New York, NY 10021.

AQUATIC ECOLOGIST. A 1.5-year POSTDOC-TORAL POSMON is available in May 1990 to studyfactors affecting the distribution offishes in Lake Tahoe,California. SCUBA certification required. Additionally,the individual will teach aquatic ecology for one to twoquarters at Utah State University. Sendletter, curriculumvitae, and names, addresses, and telephone numbers ofthree references to: Dr. W. A. Wurtsbaugh, Depart-ment ofFisheries and Wildlife, Utah State University,Logan, UT 84322-5210. Telephone: 801-750-2584.

POSTDOCTORAL RESEARCH POSMON.Immediate opening in research laboratory involved instudying cytokine expression in the "wasted" mousemodel. Experience in molecular biology or immunologypreferred. Send r6sum6 to: Dr. G. R. Libertin, LoyolaUniversity Chicago, 2160 South First Avenue, May-wood, IL 60153. Loyola University is an AffinnativeAction/Equal Opportunity Employer.

POSTDOCTORAL POSMONS. Two positionsavailable to study angiogenesis in the ovary, utilizingPCR, DNA sequencing, and other modem moleculartechniques to analyze the expression of angiogenic fac-tors, both known and novel, by ovarian cells. Training incellular physiology, biochemistry, or molecular biologydesirable. Available I Ma and 1 July 1990. To apply,send curriculum vitae to: D. Robert D. Koos, DePart-ment of Physiology, University of Maryland Schoolof Medicine, 655 West Baltimore Street, Baltimore,MD 21201. Call 301-328-8033 for additional inforna-tion. Equal Opportunity/Affirmative Action Employer.POSTDOCTORAL POSMON. Available irnme-

diately in protein biochemistry. Research focus on char-acterization of sperm membrane proteins and investiga-tion ofsperm development at the molecular level. Strongemphasis will be placed on isolation of protcins ofinterest. Candidate should have a Ph.D. or equivalent inprotein biochemistry. Cytogam, a rapidly growing bio-technology company, offers competitive salary and bene-fits, and Ihe opportunity for significant contribution tothe organization. Applicants should send a r6sume, re-ptints of publications, and three references to: Dr. Marc

Besman, Cytogam, Inc., 3498 North San MarcosPlace, Suite 7, Chandler, AZ 85224. Equal OpportunityEmployer.

9 MARCH I990

The Merrell Dow Research InstituteDistinguished Discoveries, Distinctive Careers

Innovative science and drug discovery are the goals of the Merreil Dow Research Institute. Incardiovascular diseases, CNS pharmacology, tumor biology, inflammatory diseases andmetabolic diseases, we are advancing the state of the science through Research Discovery, DrugDevelopment and Medical Research. Work with other eminent scientists at Merrell Dow in acreative environment which encourages original research, publications and collaborations. Thenew facilities are well equipped with state-of-the-art technology. Challenging opportunities arecurrently available for the following:

PROTEIN PHOSPHORYLATION BIOCHEMISTWe have a challenging career opportunity for a Senior Research Biochemist to conduct researchdirected toward an understanding of the role of protein phosphorylation and protein kinases in receptorfunction and cellular processes. The preferred candidate should have a broad background with 5-10years experience beyond the Ph. D. degree. Familiarity with the isolation and assay of various kinasesand the ability to identify specific phosphoprotein substrates and the consequences of phosphoryla-tion on protein functions would be added advantages. The position includes responsibility for a multi-ple disciplinary research program related to therapeutic targets in the cardiovascular, CNS and cellbiochemistry groups. The person should have strong communication skills with a track record ofpublishing in peer-reviewed journals. (Job Code RU)

SENIOR RESEARCH IMMUNOLOGIST-CELLULAR IMMUNOLOGY

This position entails basic mechanistic studies of antitumor and antiviral immune respones, in vitroand in vivo, with the intention to identify novel targets and therapies. Applicants must have a Ph.D.in immunology with 2-5 years postdoctoral training, excellent communication skills, and a record ofaccomplishments as evidenced by recent publications. Experience regarding the regulation of lym-phocyte surface antigen/receptor expression and function at the molecular or cellular level would bedesirable. The successful candidate will be expected to establish an independent and collaborative-type research effort in basic immunologyNirology within an existing group of cell biologists. (Job CodeTLB)

SENIOR RESEARCH MOLECULAR BIOLOGIST-RECOMBINANT DNA/PROYTEIN TECHNOLOGY

We seek an experienced investigator skilled in the design, development and manipulation of variousprokaryotic and eukaryotic gene expression systems for research scale recombinant protein produc-tion. Expression systems of interest include bacteria, yeast, baculovirus, mammalian cells andoocytes. Specifications require a Ph.D. with a minimum of 2-5 years experienye beyond postdoctoraltraining in gene cloning, sequencing, synthesis and construction of expression vectors. Excellent oraland written communication skills are required. The successful candidate will complement a groupof protein and biophysical chemists and must be able to function as an integral team member to solveproblems in protein chemistry of therapeutic interest. (Job Code ADC)

SENIOR RESEARCH PHARMACOLOGISTWe have an immediate opening in Pharmacological Sciences for a scientist to conduct researchdirected toward new therapeutic approaches for different cardiovascular disorders. The individualwould be expected to carry out studies in isolated tissues, cultured cells and in vivo models, examin-ing endogenous vasoactive agents for their roles in normal and pathological processes andcharacterizing new pharmacological agents. They would be part of a multidisciplinary research staffwhere development of the individual scientist and collaboration is encouraged. The individual shouldhave a Ph.D. degree and postdoctoral experience in isolated tissue pharmacology. (Job Code RCD)

We offer excellent compensation, comprehensive benefits including relocation assistance, thethe opportunity to contribute significantly to our ongoing achievement. To find out more aboutyour advantages with MDRI, please send your resume, Indicating position of Interest to:Personnel Services Manager.

Merrell DowMERRELL DOW RESEARCH INSTITUTE

2110 East Galbraith RoadCincinnati, OH 45215

Equal Opportunity Employer M/F/H/V

THE

SCIENCE

RECRUITMENT

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NOW YOU CAN SEE YOURAD IN SCiENCE FOUR DAYSAFTER SUBMISSION

Scientific Recruiters can now advertisepositions almost as soon as the needarises. Instead of reserving space a monthor more in advance, you can now placeyour ad four days before the magazinemailing date. SCiENCE iS mailed on thecover date.

Film (right-reading, emulsion face down)or full camera ready art and insertionorder must reach: SCiENCE, Short CloseDesk, 1515 Broadway, New York, NY10036 by NOON Mondays (except forlegal holidays when material must reachNew York by Noon Fridays). Becausespace is limited, the four-day close pagewill be reserved on a first-come, first-served basis, at a 15% premium. 1/4 and/2 page ads only.

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For further information, telephone Ed.Keller, Recruitment Advertising Manager,or Donna Rivera, Production Manager atSCiENCE : 212-730-1050, or write to:SCiENCE, 1515 Broadway, NY, NY 10036.

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Research AssociateGenentech, Inc., a leader in the field ofbiothnolog has anexcellent opportunity for aReah Associate.In this posidon, you will be responsible for the daily manage-ment, operation and maintenance of a fluore ce activatedcell sorting facility. Tis involves operat both Coulter and BDequipment, perfonming 1-5 color analysis with either singie,dual or triple laser excitation and involvement in the develop-ment and application ofnew tehnologies. To qual, you willhave 5+ years' experience in flow cytometry and a thoroughknowledge ofcomputer technology, electronics/optics(desirable) and cell culture.Genentech, Inc. offers an excellent salary and benefits packagcoupled with the opportunity to make a significant contributionto our organizaon. For consideration, please send yourresume to Yvonne Davino, Human Resources Dept. GR,Genentech, Inc., 460 Point San Bruno Blvd., South SanFrancisco, CA 94080. We actively support and promoteaffirmative action and equal employment opportunity. Womenand minorities are encouraged to apply.

On&.

,On&

NEUROSCIENCEBAYLOR COLLEGE OF MEDICINEThe Division of Neuroscience at Baylor College ofMedicine, a free standing basic science division, isrecruiting faculty members with research interests inneural systems, sensory processing and cortical func-tion and development. The goal of our recruiting is toestablish a critical mass of independent junior andsenior investigators with shared interests. Individualsin this group will be part of the Division of Neurosci-ence, joining other faculty with research programstaking molecular, biochemical, biophysical, or theoret-ical approaches to related problems in Neuroscience.Although these new faculty will become part of anactive graduate and post-graduate training programand will teach at the graduate level, they will devotethe vast majority of their efforts to the execution of avigorous, independent research program. Applicantsshould send a curriculum vitae, a statement of re-search interests, and the names of four references to:

James W. PatrickDivision of Neuroscience,

Baylor College of Medicine,One Baylor Plaza,

Houston, Texas 77030.

Baylor College of Medicine is an Equal OpportunitylAffirmative Action Employer I .

CellularToxicologistPharmaceutical Research

The Parke-Davis Pharmaceutical Research Division ofWarner-Lambert, a world leader in pharmaceutical develop-ment, has an immediate opening in the Toxicology Departmentfor a scientist to conduct cellular toxicology studies to supportdrugs in development and to explore in-vitro alternatives to an-imal testing.Qualifications for the position include a Ph.D. with two or moreyears of relevant experience. This individual should have broad-based culture experience in one or more areas, (e.g.: primarycell culture, cell line maintenance, human tissue studies, tissueslice/organ culture) coupled with experience in the assessmentof cellular toxicity. The ideal candidate would be a self-directedindividual who is willing to work in a collaborative environmentand who has demonstrated the ability to design and initiate newprojects and carry them through to completion.Join the exciting research and development team at Parke-Davis and enjoy outstanding compensation and environment.Our modern facilities are located adjacent to The University ofMichigan. Interested, qualified applicants should send their cur-riculum vitae and names of three references in confidence to:Ms. S. Hultquist, Human Resources Department, Parke-Davis, Research Division, Warner-Lambert, 2800 PlymouthRoad, P.O. Box 1047, Ann Arbor, Ml 48106-1047. "Smoke-Free Work Environment""Equal Opportunity in Action"

PARKE-DAVISA DIVISION OF

Abbott Laboratories' Pharmaceutical Products Division is continuing to lead the way in the development and manufactureof anti-infective, cardiovascular and anti-convulsant/neurological products. Supported by a significant investment to R&D, twicethe industry standard, we perform renowned clinical studies, and maintain a variety of specialized labs featuring advanced developmentaltechnologies. Our extensive technical resources create a superior environment for those who would like to make a significantpersonal and professional commitment.

MACROMOLECULAR CRYSTALLOGRAPHY ASSOCIATESThe Computer Assisted Molecular Design group is expanding its protein crystallography laboratory to support Discovery

Projects. This group is dedicated to the discovery of potent new pharmaceutical agents by combining x-ray crystallography andmolecular graphics with energy and molecular dynamics calculations. Rational drug design also plays a major role in our researchstrategy and methodology. Your involvement with Abbott's crystallography group will include research into a number of structuraltargets related to the areas of neurosciences, immunosciences, and inflammatory, cardiovascular, bacterial and viral diseases. TheProtein Crystallography Laboratory is equipped with two Rigaku 12 kw rotating anode x-ray generators, a Rigaku high speeddiffractometer, and a Nicolet-Xentronics area detector, as well as state-of-the-art computing and graphics facilities.

Postdoctorates-The selected individuals need a Ph.D. in macromolecular crystallography or a related field. Experiencein protein biochemistry is desirable.

Research Associates-The ideal candidates will have an M.S. or a B.S. and research experience in protein purification andbiochemical characterization. Experience in areas related to protein crystallography, particularly in the areas of crystallization, heavyatom derivative preparation, data collection by film, diffractometry, or area detector methods are desired.

Abbott is located in an attractive suburban area approximately 30 miles north of Chicago. We provide competitive compensationand benefits, including a profit sharing and a stock retirement plan. For immediate consideration, please send your resume withsalary requirements to: Patricia Handy, Corporate Placement, Job #7623, Abbott Laboratories, One Abbott Park Rd.,Abbott Park, IL 60064. Abbott is an Affirmative Action Employer.

ABBOTT LABORATORIESQualityHealth CareWorldwide

1888-1990

SENIOR SCIENTISTPOSITIONS

Department of DrugsThe American Medical Association, one of the nation's leading advocatesof better public health, is currently seeking two Senior Scientists to joinour challenging, progressive Department of Drugs.The successful candidates will review and evaluate pertinent literature,consult with various experts, and organize and present acquired medicalknowledge for the AMA's Drua Evaluations. Additional responsibilitieswill include: serving as an AMA topical resource professional; represen-ting the Department of Drugs at national meetings; and aiding in thedevelopment of AMA drug legislation positions.Candidates for both positions must have an M.D. or Ph.D. in pharma-cology (or related biomedical science) or PharmD degree.Knowledge/training/experience in generalpharmacology is essential.Individuals with a background in cardiovascular/renal pharmacologyor metabolic diseases/endocrinology or infectious diseases are of par-ticular interest. Publication and professional experience in academic,governmental, or industrial pharmacology is highly desired.Qualified candidates should find Senior Scientist positions in the AMA'sDepartment of Drugs to be excellent alternative career opportunitiesto traditional laboratory research or patient care environments.In addition to the challenge of these positions, the AMA offers a com-petitive compensation/benefit package and national visibility.Please send resume and salary history to:

Div. of Placement,Dept. PP/SDB-1690, NIAMERICAN MEDICALASSOCIATION, °535 N. Dearborn Street,Chicago, IL 60610. -\,Equal Opportunity Employer. \ c

I

POSITIONS OPEN

POSTDOCTORAL POSMON. The MicrobialBiochemistry and Genetics Department of the MedicalResearch Division of American Cyanamid Company hasan immediate opening for a postdoctoral researcher tostudy the tetracycline efflux pump of E. coli, whichconfers resistance to tetracycline. The position is for 2years, with a possible extension for a third year. Candi-dates should have a strong background in moleculargenetics and/or biochemistry. The Medical ResearchDivision is located at Lederle Laboratories, 25 milesnorth ofNew York City. We offer a competitive startingsalary and excellent benefits. Interested candidates maysubmit curriculum vitae and the names of three refer-ences to: Professional Employment Office, Depart-ment IC, Lederle Laboratories, North MiddletownRoad, Pearl River, NY 10965. An Equal OpportunityEmployer, MIF.

POSTDOCTORAL POSITION(S). Available indiabetes-related research to study signal transduction ofinsulin secretion including intracelifular calcium, phos-pholipid-derived mediators, protein phosphorylation,and cellular mechanisms of cytokines. Experience inbiochemistry or cell biology desirable. Salary based onNIH scale. U.S. citizenship required. Send curriculum vitaeand names of three references to: Dr. Michael L.McDaniel, Department of Pathology, Box 8118,Washington University School of Medicine, 660South Euclid Avenue, St. Louis, MO 63110. Tele-phone: 314-362-7435.

Ph.D. IN BIOCHEMISTRYA Ph.D. in biochemistry is being recruited to develop

a basic research laboratory in the Department of Urolo-gy. Preference will be given to applicants who haveexperience in cancer research. Level of appointrnent andsalary will be commensurate with expenence. Interestedindividuals are invited to submit curriculum vitae andthree letters of reference to: Dr. Jerry Sulivan, Profes-sor and Chairman, Department of Urology, Louisi-ana State University Medical School, 1542 TulancAvenue, New Orleans, LA 70112.

Equal Opportunity/Afirmative Action Employer.

POSTDOCTORAL POSITIONITHEORETI-CAL BIOPHYSICAL CHEMISTRY. To participatein developing and applying molecular dynamics methodin crystallographic refinement of biomolecules, and tostudy protein-DNA interactions in collaboration withtheoretical chemists and experimental molecular biolo-gists in the department. Knowledge in crystallography,molecular dynamics, molecular orbital calculationsFORTRAN programming, and computational work areadvantageous, but candidates with different backgroundswill be considered. We are equipped with good comput-ing facilities including CONVEX C-220, Silicon Graph-ics 4D/240, Silicon Graphics workstations, and access tosupercomputers. Please send r6sume and two letters ofrecommendation to: Dr. Chung F. Wong, Departmentof Physiology and Biophysics, Box 1218. The MountSinai School of Medicine, New York, NY 10029-6574. Affinmative Action/Equal Opportunity Employer.

RESEARCH ASSOCIATES. Available immediatelyin the areas of protein biochemistry, molecular biology,and cell culture. Candidates should have a B.S. degreewith at least 2 years ofrelevant experience or M.S. degreein life sciences. Demonstrated ability for independentwork and effective communication is expected. Cytogam,a rapidly growing biotechnology company, offers com-petive salary and benefits, and the opportunity forsignificant contribution to the organization. Applicantsshould send a resume and three references to: Dr. MarcJ. Besman, Cytogam, Inc., 3498 North San MarcosPlace, Suite 7, Chandler, AZ 85224. Equal OpportunityEmployer.

CARBOHYDRATE CHEMISTRY OF TUMOR-ASSOCIATED MUCINS, POSTDOCTORAI/RE-SEARCH ASSOCIATE. To isolate and/or synthesizespecific oligosaccharide/glycopeptide structures frommucins for structural charactenzation and immunochem-ical correlations. Experience in synthetic organic chemis-try and analytic carbohydrate chemistry useful. Pleasesend curriculum vitae and the names of three referencesto: Dr. David Gold, Center for Molecular Medicineand Immunology, University ofMedicine and Dentis-try ofNew Jersey (UMDNJ), 1 Brace Street, Newark,NJ 07103.

POSTDOCTORAL RESEARCH ASSOCIATEA position is available at the Biophysics Department,

Roswell Park Cancer Institute, for a person with a Ph.D.in peptide chemistry/chemistry. Experience in design andsynthesis (by solution and solid-phase method) of a-helical and immunologically active peptides, in theirpurification (by HPLC) and in their characterization ofpeptides is essential. Experience in crystallization, x-rayanalysis, NMR, and immunological studies is desirable.Salary: $22,000 per year. Send curriculum vitae to: Dr.H. Box, Biophysics Departmcnt, Roswell Park Can-cer Institute, Elm and Carlton Streets, Buffalo, NY14263. Roswell Park is an Equal Opportunity/AffirmativeAction Employer.

POSTDOCTORAL RESEARCH ASSOCIATE.Directed mutagenesis study of the role of amino acidresidues at an enzyme active site. Candidates for aposition in this project should have research experiencem enzymology or biophysical chemistry. For recentpublished work by the group, see J. Biol. Chem. 264,9391 (1989), and 265, 2740 (1990). Training will beprovided in obtaining rate constants for ligand bindingand release, interconversion of conformers, and catalysis.Methods for the study oftransient state kinetics as well assteady state kinetics will be included. Starting salary:$22,000 or higher depending on relevant experience. Toapply send curriculum vitae and three references to: Dr.R L. Blakley, Department of Biochemical and Clini-cal Pharmacology, St. Jude Children's Research Hospital, 332 Nort Lauderdale, Memphis, TN 38101.An Equal Opportunity Employer.

RESEARCH ASSOCIATE. Loyola University Chi-cago, Department of Pathology, seeks a research asso-ciate to work on tissues for research purposes. Requiredis a familiarity with electron microscopic and immuno-histochemical techniques: processing of tissues, cuttingof sections (semithin and ultrathin), staining of sections,photography, use of electron microscope, cutting oftrozen sections, immunofluorescence labeling. Desired isexperience in research and familiarity in handling smalllaboratory animals. Send curriculum vitae an threereferences to: Dr. Maria M. Picken, Departmt ofPathokogy, Loyola Unity Medical Center, 2160South First Av , Maywood, IL 60153. Loyola Uni-versity is an Affirmative Action/Equal Opportunity Employer.

RESEARCH ASSOCIATE (postdoctoral) in molec-ular parasitology. The successful candidate will partici-pate in an NIH-funded project studying the molecularbasis of antigenic variation in the protozoan parasite,Giardia lamblia. Research experience in molecular biologyis preferred, but other backgrounds will be considered.Ph.D., M.D., or equivalent degree is required. Salary iscommensurate with experience. The review of applica-tions will continue until position is filled. Plcase respondwith curriculum vitae and three referees to: RodneyAdam, M.D., Infectous Disease Section, Universityof Arizona College of Medicine, 1501 North Camp-bell, Tucson, AZ 85724. The University ofArizona is anEqual Opportunity/Afirmative Action Employer. Women andminorities are encouraged to apply.

RESEARCH INSTRUCTORS, POSTDOCTOR-AL FELLOWS, AND TECHNICIANS. Availableimmediately for well-funded new initiative. Genomicproject involving novel tumor suppressor and its genewhich is especially significant in cancers of blacks; nucle-ar structure/function, DNA repair, and cell cycle progres-sion. Laboratory is located in pleasant Georgetownenvironment, considerable interaction with nearby NIH.Cloning expericnce required. Applications from minoritiesare encouraged. Salaries will be commensurate with experi-ence. LABORATORY ADMINISTRATOR also re-quired. Contact: Dr. Mark Smulson, Department ofBiochemistry and Molecular Biology, orgetownUniversity School of Medicine, Washington, DC20007. Telephone 202-687-1718.

ASSISTANT SPECIALIST (annual salary range$29,136 to $33,372). Duties are to conduct rescarch onthe mechanism of bovine papilloma virus replication,including development of in vitro BPV replication;cloning and cxpression ofproteins involved in replicationand their regulation; and characterization of the proteinfactors, etc. Ph.D. in biochemistry. Job site and interviewwill be at Berkeley, California. Send this ad and yourresum6 to: Job #WS 12611, P.O. Box 9560, Sacra-mento, CA 95823-0560, no later than 24 March 1990.

The Environmental Research Laboratory of the Unit-ed States Environmental Protection Agency (USEPA) inGulf Breeze, Florida, invites applications for three posi-tions:* SUPERVISORY RESEARCH PATHOBIOL-

OGIST, GM- 14 ($50,342 to $65,444), who will serve aschief of the Pathobiology Branch, take an active role inthe development ofa new center for marine and estuarinedisease research, and develop an active research programappropriate to the mission of the branch.* RESEARCH MICROBIAL ECOLOGIST, GM-

13 ($42,601 to $55,381) to GM-14 ($50,342 to$65,444), who will serve as matrix manager for theEnvironmental Protection Agency Biotechnology RiskAssessment Program and conduct research in an area ofaquatic microbial ecology.

* RESEARCH MICROBIOLOGIST, GS-13($42,601 to $55,381), to conduct research dealing withthe degradation of xenobiotic chemicals by microbialcommunities and the development of biological treat-ment strategies applicable to the bioremediation of haz-ardous wastes.Send all inquiries for application packages by 13 April

1990 to:USEPA

Human Resources OfficeP.O. Box 98516

Las Vegas, NV 89193-8516Applicants must be United States citizens. The USEPA is

an Equal Opportunity Employer.

RESEARCH CHEMIST. To conduct research onlubricant additives for replacement in automotive/indus-trial oils; design equipment and develop processes toevaluate additives and functions and test possible replace-ments; design, plan layout, and oversee workers engagedin constructing, controlling, and improving equipment;design equipment to control movement, storage, andpackaging of additives; analyze operating procedures,equipment, and machinery functions to reduce process-ing time and cost; determine most efective arrangementofunit operations accounting for process requirements,economic evaluation, operator effectiveness, and physicaland health hazards; perform tests and take measurementsthroughout production stages to determine degree ofcontrol over variables (condensers, kilns, tanks, andboilers); design and plan measurement and control sys-tem based on data collected in laboratory experiments;conduct research in Fourier transform infra-red spectros-copy and calorimetric analysis. Ph.D. in physical organicchemistry required as well as 2 years of experience in joboffered or 2 years of experience as research associate.Must have conducted academic research in energy-relat-ed chemical processes as evidenced by publication in aprofessional journal. Must have completed at least onecourse each in molecular spectroscopy and polymerstability. Experience with functional tide of postdoctoralresearch associate acceptabk. Experience must have in-cluded at least 1 year each in Fourier transform infra-redspectroscopy and calorimetric analysis; 40 hours perweek, 9:00 a.m. to 5:00 p.m., $45,400 per year. Sendr6sume to: Illinois Department ofEmployment Secur-ity, 401 South State-3 South, Chicago, IL 60605,Attention: Joan Sykstus, Rcference #1104-S. Employ-er-paid ad.

The cancer center of a university in northeastern Ohiois secking a RESE1ARCH INSTRUCTOR to cloneand characterize eukaryotic cell lines deficient in pyridinenucleotide and poly (adenosine diphosphate ribose) me-tabolism. The individual will also be responsible forconducting research on the physiologic effects of poly(adenosine diphosphate ribose) polymerase deficiencyand its relationship to cancer chemotherapy resistancemechanisms. Ph.D. in physics or biophysics is required.No experience required in above duties, but applicantswill qualify with 3 years of postdoctoral research experi-ence in mutagenesis, cell biology, mutant cell selection,and techniques required to stud-y pynrdine nucleotide andpoly (adenosine diphosphate ribose) metabolism; 37½2hours per week (8:30 a.m. to 5:00 p.m.), Monday toFriday, $25,000 per year. Must have proofoflegal authorityto work permanently in the United States. Send duplicatecopies of r6sum6, list of publications, and three recentreprints (no calls) to: C. Bussard,JO # 1084516, OhioBureau of Employment Serviccs, P.O. Box 1618,Columbus, OH43216.An Equal Opportunity/Affirmative Action Employer.

SCIENCE, VOL. 247I260

POSITIONS OPEN POSITIONS OPEN

IRTANT PRIVATE PHARMACEUTICALRESEARCH CENTER

(close to PARIS, West)is recruiting an

'VESTIGATORor its pharmacology unit

working on:

diabetesThe candidate we seek should haveexperience in biochemical, physiolo-gical and endocrinological techniques,and have a formation as a PhD,3rd cycle or equivalent.

Interested applicants should submittheir C. V. to PUBLIVAL/202827 Route des Gardes92190 MEUDON (FRANCE).

National Institutes of HealthPublic Health Service

Department of Health and Human Services

The National Institutes of Health (NIH) invites nominations andapplications for the position of Associate Director for DiseasePrevention. This is a Civil Service position in the Senior ExecutiveService (SES), with a salary ranging from the ES-1 to ES-4 paylevel per annum. The person selected may be eligible forPhysician's Comparability Allowance ranging $5,000 to $20,000per year. A one year probationary period must be served by theindividual selected if not currently in the Senior Executive Service.The Associate Director for Disease Prevention provides

leadership and coordination of biomedical programs that seek toimprove the Nation's health through research, research training,and the exchange of knowledge as these activities relate todisease prevention, effects of nutrition on health and progression ofdisease, and medical applications of biomedical research.

For more information, contact Dr. Paul Thibault at (301) 496-6521. The following forms are required: Application for FederalEmployment (SF-171) accompanied by a current curriculum vitaeand bibliography. These must be submitted to:

Dr. Paul Thibault Ltk_ lA4National Institutes of HealthOffice of the Director PersonnelBuilding 31, Room 1C-239000 Rockville Pike HEtESBethesda, Maryland 20892

Applications must be postmarked no later than April 9, 1990.

Selection for this position will be based solely on merit, with no discrimination fornon-merit reasons such as race, color, religion, sex, national origin, politics, maritalstatus, physical handicap, age, or membership or non-membership in an employee

organization.

NIH is an Equal Opportunity Employer

IMMUNOLOGISTS

Ph.D.SangStat Medical is a dynamic and growing companyin the field of organ transplantation diagnostics andtherapeutics, located south of San Francisco. Currentopenings exist as follows:

Immunochemists to develop novel immunoassays.

Cellular immunologists to study novel therapeuticapproaches to immunosuppression.

The successful candidates must have a Ph.D. inImmunology, Cell biology, Biochemistry or relateddiscipline and at least 2 years post-doctoral experiencewith a substantial record of productive research.

This is a unique opportunity for outstanding individuals togrow quickly with a young company. SangStat Medicaloffers an excellent compensation and benefits package,including significant equity participation through stockoptions.

Please send a c.v. including references, in confidence,to: SangStat Medical, Human Resources, 3603Haven Ave., Suite D, Menlo Park, CA 94025.

SangStat Medical

RESEARCH COORDINATOR A position isavailable to participate in a research program to investi-gate visibility degradation throughout the national parksystem. Primary duties will revolve around data anafysis,exercising and developing detenrinistic and receptormodels, and graphically depicting model results. Devel-opment of analytical and graphic computer proceduresare a necessary component ofthesc responsibilhtes. Quali-fications: a minimum of a master of science in physicalscience discipline with a strong mathematical and statisti-cal background are required. A demonstrated knowledgeof VAX/VMS, VAX Fortran, MSDOS and statisticalpackages such as SAS and SPSS are highly desirable.Preference will be given to candidates with work experi-ence in the tasks identified in the description section.Application deadline: 30 March 1990. Salary commensu-rate with qualifications. Submit letter of applications andr6sume to: Professor Thomas H. Vonderhaar, Direc-tor, Cooperative Institute for Research in the Atmo-spherc (C ), Foothills Campus, Ft. Collins, CO80523. Telephonc: 303-491-8448.

RESEARCH SCIENTISTAn opening exists for a Ph.D. with a minimum of 2

years of laboratory exPerience in the development oflyophilized products. Experience in designing formula-tions for optimal lyophilization of antibody-based radio-pharmaccuticals required as well as experience with novelanalytical methodologies for characterizing product be-havior during lyophilization. Salary is $42,000 per year.State-of-the-art research and development facilities pro-vided. Send your curriculum vitae with a list of publica-tions to: Ihe Philadelphia Job Bank, 444 North 3rdStreet, 3rd Floor, IP iJdelphia, PA 19123. Responsesmust incude Job Order Number #4304914. We are anEqual Opportunity/Affirmative Action Employer.

RESEARCH SCIENTIST. Available immediately inprotein biochemistry. Research emphasis on character-ization of mcmbrane proteins. Multidisciplinary ap-proach to investigation of sperm biochemistry is re-quired. Candidate should have a Ph.D. with 2 years ofpostdoctoral experience and a strong r back-ground in protein biochemistry. Excellent communica-tion skills and demonstrated problem-solving abilities arerequired. Cytogam, a rapidly growing biotechnologycompany developing applications in the field of repro-ductive biology, ofers competitive salary and benefits,and the opportunity for significant contribution to theorganization.Applicants should send curriculum vitae,reprints of publications, and three references to: Dr.Marc J. Besman, Cytogam, Inc., 3498 North SanMarcos Place, Suite 7, Chandler, AZ 85224. EqualOpportunity Employer.

SENIOR SCIENTISTMOLECULAR BIOLOGIST

Ph.D. in molecular biology, immunology, or biochem-istry with 2 to 3 years of postdoctoral experience.Experience in cDNA library construction and screening,protein structure, function studies, and receptor doning/characterization.For immediate consideration, send your resume indi-

cating salary history and position to:Director

Institute of Primate ResearchP.O. Box 24481, Karen

NairobiKenya

Emory University is an Afirmative Action/Equal Opportu-nity Employer.TOXICOLOGIST. Technical Assessment Systems,

Inc. (TAS), a scientific consulting firm specializing inrisk assessment of chemicals in food, water, and theenvironment, offers oppornmities fur highly motivated,self-starting toxicologists with industriarand/or regula-tory expenence. The position involves management oftoxicology and risk assessment projects, monitoring stud-ies, and providing regulatory compliance assistance tointernational clients. Successful candidates will have anadvanced degree and a proven record of accomplishmentin the field of toxicology. Excellent communication andorganizational skills required. Familiarity with GLPsand FIFRA guidelines and regulations desirabk. TASoffers a competitive salary and benefits package. Pleasesend rdsumd and salary history to: Alan Katz, TechnicalAssessment Systems, Inc., The Flour Mill, 1000 Po-tomac Street,-N.W., Washington, DC 20007. We arean Equal Opportunity Employer.

POSTDOCTORAL FELLOW. Position open tostudy systemic and renal hemodynamics and chanzes invasoactive humoral substances before and after rtereddivalent ion nutrition. Ph.D. in physiology or phanna-cology required. Position is for 2 years ofsupport; salaryis negotiable. Closing date: 1 May 1990. Submit curricu-lum vitae to: Edward T. Zawada, Jr., M.D., Professorand Chairman, University ofSouth Dakota, School ofMedicne, P.O. Box 5046, Sioux Falls, SD 57117-5046. Afirmative Action/Equal Opporunity Employer.

POSTDOCTORAL FELLOW. Three-year positionavailable 1 May 1990 to do structure-function analysesfor an enzyme which confers bacterial drug resistance.Prefer individual with background in Protein biochemis-try and expertise in standard molecular biological tech-niques. Previous experience with site-directed mutagene-sis useful but not required. Send curriculum vitae andthree letters of reference to: Dr. Michael H. Perlin,Department of Biology, University of Louisville,Louisvillc, KY 40292. The University of Louisville is anEqual Opportunity Employer.

POSTDOCTORAL FELLOWSHIP. The Rein-gold ECG Center, Cardiology Section, at NorthwesternUniversity Medical School is seeking a candidate whowill study the cffects of inotropic agents on cardiaccellular electrophysiology and intracellular calcium tran-sients (using indo-1 fluorescence). M.D. and/or Ph.D.required; experience with cellular electrophysiologicaltechniques preferred. Se;id curriculum vitae and threeletters of reference to: Dr. J. Andrew Wasserstrom,Reingold ECG Center, Northwestern UniversityMedical School, 303 East Chicago Avenue, Chicago,IL 60611. An Equal Opportunity/Affirmative Action Em-ployer. Employment eligibility verification required upon hire.

POSTDOCTORAL FELLOWSHIP. Molecularneurobiology in the Departments of Neurology andBiological Chemiistry to study S100 gene expression,glial:neuronal differentiation, and control ofglial-specificgene expression. Candidates for this NIH-funded, 3-yearposition should have a Ph.D. and experience with molec-ular biological techniques, preferably including DNasefootprinting and DNA/protein interaction assays. Posi-tion available spring of 1990. Send r6sume to: DanaHilt, Department of Neurology, University of Mary-land School of Medicine, 22 South Greene Street,Baltimore, MD 21201. The University ofMaryland is anEqual Opportunity Employer.

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COURSES AND TRAINING

TRAINING IN ESR SPECTROSCOPYThe National Biomedical ESR Center offers a 2-week

intense trainin in ESR spectroscopy. The programsponsored by 4IH, is designed to provide ands-onopportunities in many advanced ESR techniques forgraduate students and faculty members who have at leastsome previous experience working with ESR. The awardincludes travel expenses up to $500. Send a letter andone-page research plan (student applicants should in-lude a letter from graduate adviser) to: Dr. Ching-San

Lai, National Biomedical ESR Center, Medicaf Col-lege of Wisconsin, 8701 Watertown Plank Road,Milwaukee, WI 53226. Telephone: 414-266-4051.Equal Opportunity/Afirmative Action Employer, M/F/H.

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Operon Technologies, Inc.Operon Technolegies is a leading manufacturer of syntheticDNA. serving over 500 laboratories worldwide. Let us meetyour DNA needs with economical pricing, rapid turnaroundand an unconditional guarantee.Custom synthesized DNA: 1 umole scale at $5 per base.$25 set-up fee per sequence. Economical prices forpurification and larger scales. Stock primers and linkersat $50 for 1 OD.1000 Atlantic Ave., Suite 108. Alameda. CA 945011-800-688-2248 Tel 415 865-8644 Fax 415 865-5255

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SCIENCE, VOL. 247

POSITIONS OPEN

BUILDING A NEW LAB?Let the free Science product information ser-vice put you in touch with the vendors whoseproducts you will need.

Simply write us a letter stating the specificsabout your proposed lab and we will do therest. Write to:

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On May 9,1990, you'll have anunprecedented opportunity to dis-cuss the latest advances in proteincharacterization with three of themost prominent figures in thefield: Dr. Csaba Horvath of YaleUniversity, Dr. William Hancock ofGenentech, and Dr. Rod Levine ofNIH. Topics include characteriza-tion of biological molecules by

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