Potential anti-bacterial agents: Montmorillonite Clay catalyzed synthesis of novel 2-(3, 5-substituted-1H-pyrazol-1-yl)-3-substituted quinolones and their in-silico molecular docking studies Pasupala Pavan, R. Subashini*, K. R. Ethiraj and Fazlur-Rahman Nawaz Khan*
Supplementary files
Fig. 1: GC-MS spectrum of 1-(3-(1,3-dioxolan-2yl)-8-methylquinolin-2-yl)hydrazine, 2e
N NHNH2
O
O
C13H15N3O2Exact Mass: 245.12
Electronic Supplementary Material (ESI) for RSC Advances.This journal is © The Royal Society of Chemistry 2014
Fig. 2: 1H NMR spectrum of 1-(3-(1,3-dioxolan-2yl)-8-methylquinolin-2-yl)hydrazine, 2e
N NHNH2
O
O
-CH2-CH2
-NH2
-CHAr-H
-NH
-CH3
Fig. 3: 13C NMR spectrum of 1-(3-(1,3-dioxolan-2yl)-8-methylquinolin-2-yl)hydrazine, 2e
N NHNH2
O
O
-CH3
-CH2-CH2
-CH
Ar-C
Fig. 5:1H-NMR spectrum of 2-pyrazoloquinoline-3-carbaldehyde, 4
N N
O
N
C16H15N3O
3-CH3
-CH-CHO
Ar-H
Fig. 6:13C-NMR spectrum of 2-pyrazoloquinoline-3-carbaldehyde, 4
N N
O
N
C16H15N3O
3-CH3
Ar-C
-CHC=O
Fig. 7: 1H-NMR- spectrum 2-(3,5-dimethyl-1H-pyrazol-1-yl)-3-(1,3-dioxolan-2-yl)quinoline,
N N
O
O
N
H3C
CH3
C17H17N3O2
2-CH3
-CH2-CH22-CH
Ar-H
5a Fig. 8: 13C-NMR- spectrum 2-(3,5-dimethyl-1H-pyrazol-1-yl)-3-(1,3-dioxolan-2-yl)quinoline, 5a
N N
O
O
N
H3C
CH3
C17H17N3O2
2-CH3
CH2-CH2
Ar-C
Fig. 10: 1H-NMR- spectrum of 3-(1,3-dioxolan-2-yl)-2-(3-methyl-5-phenyl-1H-pyrazol-1-yl)quinolone, 5b
Fig. 11: 13C-NMR- spectrum of 3-(1,3-dioxolan-2-yl)-2-(3-methyl-5-phenyl-1H-pyrazol-1-yl)quinolone, 5b
Fig. 14: 1H-NMR- spectrum of 2-(3,5-dimethyl-1H-pyrazol-1-yl)-3-(1,3-dioxolan-2-yl)-7-methylquinoline, 5d
Fig. 15: 13C-NMR- spectrum of 2-(3,5-dimethyl-1H-pyrazol-1-yl)-3-(1,3-dioxolan-2-yl)-7-methylquinoline, 5d
Fig. 16: HRMS-spectrum2-(3, 5-dimethyl-1H-pyrazol-1-yl )-3-(1, 3-dioxolan-2-yl)-7-methyl quinoline, 5d
Fig. 17: HRMS-spectrum3-(1,3-dioxolan-2-yl)-7-methyl-2-(3-methyl-5-phenyl-1H-pyrazol-1-yl)quinoline, 5e
Fig. 18: 1H-NMR- spectrum of 2-(3,5-dimethyl-1H-pyrazol-1-yl)-3-(1,3-dioxolan-2-yl)-7,8-dimethylquinoline, 5f
Fig. 19: 13C-NMR- spectrum of 2-(3,5-dimethyl-1H-pyrazol-1-yl)-3-(1,3-dioxolan-2-yl)-7,8-dimethylquinoline, 5f
Fig. 20: HRMS-spectrum2-(3,5-dimethyl-1H-pyrazol-1-yl)-3-(1,3-dioxolan-2-yl)-7,8-dimethylquinoline, 5f