FLORJAT- 30

• Montajat- The First Company in the World to Formulate Florjat- 30

• Do a Complete Pharmacokinetic Profile

• Papers Accepted for Publication in International Journals e.g. JVPT, and AJVR

• Product Sales Turnover- More than USD 1 Million in 2006

• Drug of Choice for Salmonella, Pasteurella and E. coli

FLORJAT- 30

• Primarily for Poultry Birds (Can be Effectively Used in Mammalian Neonatal Scour)

• The Latest 3rd Generation Broad- Spectrum Antibacterial Agent

• Exclusively for Veterinary Use

• Primarily Bacteriostatic Agent (Bactericidal at higher dosage)

• Binds to 50s Ribosome, Thus Arresting Protein Synthesis

• Contains Fluorine Atom- Prevents Plasmid Mediated Resistance

• Lacks a Nitro Group- Does Not Cause Aplastic Anemia in Humans

• No Bone Marrow Suppression (Not Reported)

FLORJAT- 30

FLORJAT- 30

Semi- logarthimic Plasma Concentration time profile of Florjat- 30 following single dose (30 mg.kg-1) oral

administration in poultry

PHARMACOKINETIC PATH

0.1

1.0

10.0

0 5 10 15 20 25

A

Observed

Predicted

FLORJAT- 30

Conclusion: The time for plasma concentration above 1 μg/ml is more than 24 hours. Therefore, Florjat- 30 should be given at a dosage of 30mg/kg to be repeated every 24 hours following oral administration.

PHARMACOKINETIC PARAMETERS-

Parameters Units Animal No. Mean±SE

I II III IV V VI

Ka h-1 1.57 1.77 1.58 0.77 2.44 2.03 1.69±0.22

Ke h-1 0.109 0.157 0.065 0.144 0.069 0.122 0.11±.01

t1/2 Ka h 0.44 0.39 0.436 0.890 0.283 0.341 0.46±.08

t1/2 Ke h 6.34 4.93 10.564 4.785 10.018 5.682 7.05±1.05

AUC g.mL-1.h 90.77 82.05 116.82 113.37 122.28 85.57 101.81±7.19

CL/F mL.kg-1.h-1 0.33 0.36 0.25 0.26 0.24 0.35 0.29±0.02

Tmax h 1.88 1.50 2.09 2.45 1.34 1.45 1.78±0.17

Cmax μg.mL-1 8.129 9.26 6.68 11.18 7.62 8.72 8.59±0.63

Vd/F L.kg-1 3.03 2.32 3.59 1.83 3.57 2.87 2.86±0.28

FLORJAT- 30

Sl No. Organ Conc. (mcg/g)

24 hrs 72 hr 96 hrs

1. Liver0.034±0.002

ND ND

2. Heart0.094±0.005

0.05±0.006 ND

3. Intestine0.026±0.003

0.048±0.030 ND

4. Spleen0.134±0.005

0.079±0.003 ND

5. Lung ND ND ND

6. kidney ND ND ND

7. Muscles ND ND ND

ND – not detectable

Tissue concentration (µg/g) of Florjat- 30 oral solution following multiple (5) dose (30 mg/kg) oral administration in

poultry

WITHDRAWAL PERIOD-

FLORJAT- 30

LD50 of Florfenicol in poultry is 1333.52 mg.kg-1.

LD 50, IM (Poultry Birds)-

S.No.

Group Dose(mg.kg-1) Log dose

Dead Dead % Corrected Probit

1 I 1250 3.097 0/4 0 6.25 3.46

2 II 1275 3.106 1/4 25 25 4.33

3 III 1300 3.114 1/4 25 25 4.33

4 IV 1325 3.122 2/4 50 50 5.00

5 V 1350 3.130 3/4 75 75 5.67

6 VI 1375 3.138 4/4 100 93.75 6.57

FLORJAT- 30

Bioavailability (Poultry Birds)-

• 96%

Usage Recommendations-• 30mg/ kg bw, Once Daily in Continuous Drinking

Water*

• 1ml per 3 lit. of Drinking Water, continuously for 5 days (depending upon the water consumption)

Florjat 30%

Packs Available-• 1000ml

• 5000ml

Micojat- L

• Latest Mycoplasmicidal Drug- Tilmicosin

• Highly effective on-

– Mycoplasma gallisepticum

– M. synoviae

• Enhances Cellular Immunity

MICOJAT

MICOJAT

The MIC requirement for Mycoplasma gallisepticum is 0.0125 µg/ml. From the above graphs, it is evident that Tilmicosin is highly effective in treating or preventing Mycoplasma at the recommended dosage (Jordan and Horrocks, 1996)

Medication Program

Day

Treatment*

% MortalityLesion scoreVaccination

Treatment after vaccination

*Day 1-3 Micojat, Erythromycin, Tylosin and EnrofloxacinDay 23,24,25 Micojat, Erythromycin, Tylosin and Enrofloxacin

1-3 23-25 32 35

* Fax report

* Fax report

* Fax report

RECOMMENDED USAGE-• 15-20 mg/kg body weight

• 3ml MICOJAT per 10 liter of drinking water

• Preventive Schedule-– Days 1,2 3– Days 24, 25, 26 (Days 20, 21, 22 for grow- outs @ Day 35)– Better results along with Florjat 30 (given on Days 13, 14,

15)

MICOJAT

PACK AVAILABLE- 120ml

Other Leading Products-

PRODUCT COMPOSITION INDICATIONS ADMINISTRATION PACKING

ACARICIDE

DIAZIN 600 Diazinon 600mg/ ml EC Fly repellent 1- 2ml/ ltr water 250ml, 1000ml

ANTIMICROBIAL AGENTS

COLIJAT WSP Colistin sulphate 10MIU/ gm Salmonellosis and Colibacillosis Oral; 1g/ 20 liters. 1kg

GEDOJAT WSP Gentamicin 100mg, Doxycycline 100mg/ g All bacterial infections and Mycoplasmosis Oral; 1g/ 2 liters, sid 1kg

NEOJAT WSP Neomycin (as sulphate) 100% w/w All gram -ve bacterial infections 230g/ MT feed 1kg, 25kg

NEOSIN WSP Tylosin 700mg, Neomycin 300 mg All bacterial infections and Mycoplasmosis Oral; 1g/ 2 liters, sid 1kg

RYTHROCOL WSP Erythromycin 200mg, Colistin 500,000IU/ gm All bacterial infections Oral; 1g/ 4ltrs, sid 1kg

SPECTOLIN WSPLincomycin 333 mg; Spectinomycin 667mg/ 1.5gm

All bacterial infections and Mycoplasmosis Oral; 0.75g/ltr, sid 150gm

ANTIPARASITIC AGENTS

NICLOX liq. Niclosamide 75g, Oxibendazole 10g/ ltr Roundworms, and Tapeworms Oral; 1ml/kg bw, single dose 1ltr

ANTICOCCIDIAL DRUGS

COXURIL liq. Toltrazuril 25mg/ ml Coccidiosis 7mg/ kg bw; sid, 2 days 100ml, 1Ltr

MONCOX liq. Amprolium 250mg/ ml Coccidiosis 1ml/ ltr water; for 5- 7 days 1 Ltr

Other Leading Products-

PRODUCT COMPOSITION INDICATIONS ADMINISTRATION PACKING

SUPPORTIVES

ANTOX Liq. Organic acids, Fe, Live yeast, Prebiotics (MOS) Toxin Binder, Acidifier, Probiotic, Prebiotic Oral; 1ml/ ltr 1Ltr

BROMODIL liq. Bromhexine hydrochloride BP 15mg; Chlorpheniramine Maleate BP 10mg; Mint Extract/ ml

Mucolytic expectorant; bronchodialator; anti- histaminic agent

Oral; 1ml/ 3lit. 1Ltr

ELECTROJAT NaCl 124g, Trisodium citrate dihydrate 103g, KCl 52g, Vitamin C 120g, Glucose qs/ kg

Electrolyte Anti-Heat Stress Oral; 4.5gm/ltr 100gm, 1kg

MONDIUR Methenamine 950mg, Vit B1 8 mg, Vit B2 1mg, Vit K3 2mg/ gm

As diuretic Oral;1ml/ ltr 1kg

MONSEL Liq. Vitamin E 20g, Selenium 360mg/ ltr Supplement, Immunostimulant, Mastitis prevention Oral; 1ml/ 2ltrs 1Ltr

VITAMINS

B–K-CHOLJATVit.B1 10 mg, Vit.B2 4.5mg, Vit.B6 10mg, Vit.B12 5µg, Vit.PP 50mg, Vit.K3 10mg, Choline 50mg, Ca- D Pantothenate 50mg, Folic acid 2mg/g

Laying performance Oral; 1g/ 2ltrs 1 kg

MONTA- C Vitamin C 100% w/w Stress, Immunomodulation Oral; 1g/ 8ltrs 1kg

MONTA- K Vitamin K3 (MSB) 100% Coccidiosis, cannibalism Oral; 1g/ 2400 chicks 1kg

MONTA.3 liq. Vit.A 1,00,000IU, Vit.D3 20,000 IU, Vit. E 20mg/ml Supplement, Heat stress Oral; 1g/ 2ltrs 1Ltr

MONVIT- L liq. Vit. A, D3, E, C, K, B- complex, Ca, and Amino Acids General deficiency, to improve FCR, Stress Oral; 1ml/ltr 1Ltr

Other Leading Products-

PRODUCT COMPOSITION INDICATIONS ADMINISTRATION PACKING

FEED ADDITIVES

AFLABOND HSCAS with organic acids Toxin Binder, Mold Inhibitor, and Mold Killer 500g/ MT feed 25kgs

CHOLJAT Choline chloride 50% and 60% Enhanced Laying Performance As required 25kgs

DICLACOX Diclazuril 0.5% granular Coccidiosis Prevention 200g/ MT feed 25kgs

FLAVOJAT Flavomycin 8% granular Non- absorbable Antibiotic Growth Promoter 100g/ MT feed 25kgs

L- LYSINE L- Lysine HCl source Lysine supplementation As required 25kgs

MADURAJAT Maduramicin ammonium 1% granular Coccidiosis Prevention 500g/ MT feed 25kgs

MONENCOX Monensin 20 % granular Coccidiosis Prevention 450- 550g/ MT 25kgs

PELCON Silicate based compounds Pellet Binder (silicate based; non- lignin) 2kg/ MT 25kgs

PHYTOPHOS Phytase 5000 FTU/ g Phosphorus supplementation 100g/ MT feed 25kgs

PROBAC- BMD Bacitracin Methylene Disalicylate 10% granular Growth Promoter, Necrotic enteritis 200g/ MT feed 25kgs

ROBECOX Robenidine 6.66% granular Coccidiosis Prevention 450- 550g/ MT 25kgs

SALINOCOX Salinomycin Sodium 12% granular Coccidiosis Prevention 500g/ MT feed 25kgs

ZINBAC Zinc Bacitracin 10% granular Non- absorbable Antibiotic Growth Promoter 500g/ MT feed 25kgs

Thanks…

Dr. Puneet AgrawalMarketing Manager

For more information, please contact us at:

Montajat Veterinary Pharmaceuticals Co. Ltd.

2nd Industrial City, Dammam 31491, Kingdom of Saudi Arabia

Tel: +966- 812 3221, Fax: +966- 812 3112, e- mail: info@montajat.biz

Web: www.montajat.biz