Anti-Aging Skin Care Regimen

Effective Products - Effective Delivery - Effective Sun Care 01

Basic skin structureThe problem: skin aging The solution: skin regeneration by Derma-Lucia productsHow: the mechanism of Derma-Lucia

- Neuro-peptides innovation: Neo-Endorphins andcaffeic acid

- NP-7 peptide complex and Hyaluronan function- Nano-Biotechnology innovation: Deeper penetration

Phyto Stem cell inductionSummary: Uniqueness of Derma-Lucia formulasWhy Derma-Lucia Core Products?The Complete Derma-Lucia Regimen

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Dermis

Hypodermis

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Epidermis (5 layers)

Fibroblasts are embedded in the

ECM (extracellular matrix)

Skin stem cells

Epidermis

Hypodermis

Dermis

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Epidermis

Hypodermis

De

rmis

H2OH2O

H2O

H2O

H2OH2O

H2OH2O

H2O

H2O

• Dermis layer is build of

fibroblasts

embedded in the ECM

(extracellular matrix)

• Fibroblasts secrete ECM-

building molecules:

– Collagen

– Elastin

– Hyaluronan

• Stem cells

found in the dermis are

important to replenish the

aging fibroblasts

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The skin is closely associated with the nervous system

Skin cells contain receptors that can be activated by various stimuli such as chemical signals secreted by the brain and nerve cells, endocrine organs and immune system or the mechanical stimuli such as touch

Skin function is under the tight control of neuronal, endocrine and immune systems

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Roosterman D et al. Physiol Rev 2006;86:1309-1379

Neuro-peptides are secreted from the nerve cells

Skin cells respond to the stimulation by neuro-peptides

Neuro-peptides bind to specific receptors present in skin cells and activate gene expression programs

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Roosterman D et al. Physiol Rev 2006;86:1309-1379

(The Anti-Aging Agents)

• Neo-Endorphins belong to neuro-peptides and their function is to promote the wound healing and tissue repair in the damaged skin.

• This unique function lies at the basis of the anti-wrinkle effect of

neo-endorphins on the aged skin.

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(Stimulate Stem Cells and Fibroblasts)

Neo-endorphins

• Neo-endorphins bind to

the receptors in skin cells

• Upon binding to the

receptors, signaling

cascades are induced that

lead to gene expression

programs ultimately

stimulating cell

proliferation, survival and

activity

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• Functional neuro-peptides that stimulate stem cells and

fibroblasts

• Active stem cells that replenish the pool of fibroblasts

• Active fibroblasts that secrete ECM components:

– Collagen provides plumpness and rigidity

– Elastin ensures elasticity and resilience

– Hyaluronan facilitates water retention and skin hydration

To maintain the youthful skin appearance the following

factors are essential:

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(What Happens in the Aged Skin?)

H2O H2O

H2O

H2O

H2O

H2O

H2O

H2O

H2OH2OAbundance of neuro-peptides that

stimulate stem cells and activate

fibroblasts (production of the ECM

components providing rigidity and

elasticity) and plenty of water

molecules to ensure hydration.

Young skin

Aged skin

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Lowered neuro-peptides production,

loss of stem cells and the fibroblasts

activity, (hence lowering the collagen

and elastin secretion) and further

loss of hyaluronan production results

in the reduced elasticity and

hydration.

(Stem Cells and Fibroblasts in The Aged Skin)

The pool of stem cells

in the aged skin is exhausted .

These stem cells are less efficient in dividing, proliferating and differentiating into new fibroblasts.

As a consequence, less fibroblasts.

are available to produce ECM components.

Stem cells and fibroblasts in the aged skin are either sluggish or not active.

It is essential to supply neuro-peptides that will activate stem cells and fibroblasts to propagate skin regeneration mechanism.

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(How to Regenerate Matured Skin?)

1. By supplying the unique pool of

neuro-peptides that will activate

skin stem cells and fibroblasts =>

fibroblasts renewal complemented

by wound healing process

2. By restoring collagen and elastin

production => Skin elasticity and

resilience restoration

3. By increasing water retention with

hyaluronan groups

4. By incorporating Nanoparticles to

enhance stability and deeper

delivery of the active ingredients

5. By plant callus –phyto stem cell

induction to work synergistically

Why Derma-Lucia?

Derma-Lucia unique formula provides a solution for skin

regeneration.

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(Active Components Lead to Skin Restoration)

• Alpha-neo-endorphin

• Caffeoyl-alpha-neo-endorphin

• Caffeoyl-Tripeptide

• Caffeoyl-Octapeptide

• Caffeoyl-Decapeptide

Neuro-peptides used in Derma-Lucia formula include a carefully-balanced combination of:

1. Regeneration =>

Neo-endorphin complex together with caffeic acid stimulate and activate skin stem cells and fibroblasts propagating skin restoration.

2. Elasticity and resilience =>collagen and elastinproduction+enhancement through NP-7 peptide complex function.

3. Hydration => water retention by Hyaluronan group,supplemented with phyto stem cell –plant cell callus.

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(Neo-Endorphins+ Caffeic Acid Restore Skin Integrity)

Neo-endorphins• Neo-endorphins act most

efficient when combined with

caffeic acid.

• Stem Cells serve as a

source for generating new

active fibroblasts.

• Active fibroblasts secrete

ECM components more

efficiently.

• Caffeic acid protects

metabolically active cells

from oxidative damage.

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(Neo-Endorphins Initiate Signaling Events)

Neo-endorphins

1) Neo-endorphin binding to its

receptor =>

2) Triggers the activation of

biochemical signaling events

that include protein

phosphorylation, protein

conformational changes and

protein subcellular relocation

=>

3) Leading to gene regulation

processes in the cell nucleus.

Mechanism of neo-endorphin

action:

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(Restoring Elasticity and Resilience)

Caffeoyl Tripeptide-1

Octapeptide-4

Decapeptide-7

Pentapeptide-19

Oligopeptide-28

Acetyl Hexapeptide-22

Acetyl Hexapeptide-8

NP-7 peptide complex

contains:

1. Regeneration => Neo-endorphin complex together with caffeic acid stimulate and activate skin stem cells and fibroblasts propagating skin restoration

2. Elasticity and resilience =>collagen and elastinproduction+enhancement through NP-7 peptide complex function

3. Hydration => water retention by Hyaluronan group + Phyto stem cells

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(Restoring Hydration)

Hyaluronan group

belongs to GAGs

(glycosamin-glycans, the

sugars).

Hyaluronan can retain the

amount of water 1000

times of its weight.

1. Regeneration => Neo-endorphin complex together with caffeic acid stimulate and activate skin stem cells and fibroblasts propagating skin restoration

2. Elasticity and resilience =>collagen and elastinproduction+enhancement through NP-7 peptide complex function

3. Hydration => water retention by Hyaluronan group + Phyto stem cell

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(Through Derma –Lucia Innovations)

Anti-Aging and Anti-Wrinkle

regimen of Derma-Lucia

relies on the unique formula

combining several active

groups, each of which is

responsible for a distinct

action towards skin

regeneration

- Fibroblasts

renewal

- Wound healing

process

- Anti-oxidant

protection

Collagen and

elastin

restoration

Hydration

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(Derma –Lucia Innovation)

Skinrestored

Wound healing effect enhanced by the roller treatment

Nanoparticle encapsulation; proprietary vitamin and herbal complex, plant stem cells, natural oils

Neo-Endorphin Complex with various peptide

groups provide most effective anti-inflammatory,

anti-wrinkle and anti-oxidant effect

NP-7 Peptide complex

Hyaluronangroups

Collagen and elastin Restoration + hydration

Rapid cell renewal

Anti-oxidants

Stem cell proliferation

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Roller massaging provides physical stimulation to prepare the skin surface.

Roller introduces epidermal micro-puncturespreparing the skin for efficient response to the Derma-Lucia treatment.

Roller application enhances the wound healing process, providing a more efficient delivery conduit

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• Neuropeptide stimulation…… through => stem cell division/proliferation, wound healing process, anti-oxidant protection, anti-inflammatory and anti-wrinkle effect.

• NP7-peptide complex induced collagen and elastin restoration => plumpness

• Phyto Stem Cells – plant callus induction

• Hyaluronan-mediated hydration => smoothness and anti-wrinkle effect.

• Proprietary technological driven processing steps for deeper penetration.

• Nano-Particles Innovation to achieve maximum stability of the active components for further absorption

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1. Super Aqua Toner Prep

2. Anti-Wrinkle Serum

3. Restorative Wrinkle & Eye treatment

4. Super Aqua Emulsion

5. Double Nourishing Sealer

Core Products:

Why Derma-Lucia Core Products?

Patented proprietary anti-aging actives currently not available in America / Europe

One of the highest active concentrations… working synergistically togetherUnique actives developed specific for anti-aging R & D, one of its kind.Infusion of Phyto stem cells –plant cell callusAnti-Aging Regimen combining Effective (Products + Delivery +Sun protection)

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