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REAL-TIME ACCESS TO CLEAN DATA FOR THE ENTIRE PROJECT TEAM + The Preclarus ® central lab databse, PPD Laboratories’ proprietary laboratory information system, creates a single, web-based global database that eliminates the need for integration of regional datasets + Central lab dashboards summarize integrated data to facilitate project oversight from start to finish + The Preclarus lab data portal, investigator site portal and a mobile app provide secure, real-time access to studywide data ONE GLOBAL DATABASE PPD OF HALLMARKS + Single global database allows PPD Laboratories to test regionally and combine data globally + Inherently combinable data so results accurately reflect biological variation + Real-time data cleansing saves hundreds of hours at the end of the trial + 10 globally validated platforms + Unique Global Laboratory Assay Standardization Survey (GLASS) verifies accuracy and global standardization SERVICES Helping clients understand the safety and efficacy of their drug in patients Data file to project team Test results to investigator for patient management Patient specimens sent to lab Diagnosis and treatment per protocol Patient care adjusted per test results and trial protocol INCLUSION TESTING + Initial testing for patient acceptance into trial + Baseline chemistry, urinalysis and hematology + Drugs of abuse screening + Infectious disease, biomarkers or other screening tests where appropriate SAFETY & EFFICACY TESTING + Status of bodily functions via routine chemistry, urinalysis and/or hematology + Status of disease state utilizing protocol-specific testing + Adverse event monitoring per protocol EXPLORATORY BIOMARKER STUDIES + Not typically used for patient management + Include various ‘omics methodologies (e.g., genomics, proteomics, metabolomics) CENTRAL LAB + Multiple visits per trial protocol + Data and samples collected to measure the effects of the drug in the patient PATIENT INVESTIGATOR CLIENT Visit one to conclusion of trial CENTRAL LAB 5 Weeks from final protocol to kits on site 4 Regional locations 3 Sites building custom kits 2 Million+ samples tested per year 1 Global Database ©2020 PPD, Inc. All rights reserved. FACTS THE MINISTRY OF HEALTH SINGAPORE GOVERNMENT OF CHINA Central Lab PPD ® LABORATORIES HELPING DELIVER LIFE-CHANGING THERAPIES
