Current Treatment Options for Epilepsy:

Neonate to Young Adult

Gregory B. Sharp, M.D.Chief of Pediatric Neurology

University of Arkansas For Medical Sciences

Medical Director, Neuroscience Center of Excellence

“Epsilepsee” in Arkansaw

Big Se izure

Little Seizure

“Grandma Seizure” vs. “Petit Mal Seizure”

“Mini-Mall”

Seizure Classification

Partial (Focal) Primary Generalized

Simple Complex

May secondarily generalize

Absence Myoclonic Atonic Convulsive

Tonic

Clonic

Tonic-clonic

Clonic-tonic-clonic

Partial Onset Seizure – Left Temporal

Generalized Onset Seizure Generalized Onset Seizure

FP1-F7

F7-T5

T5-O1

FP1-F3

F3-P3

P3-O1

Fp2-F4

F4-P4

P4-O2

Fp2-F8

F8-T6

T6-O2

1 sec

50 µV

Neonatal Seizures: Bilateral Foci

HypsarrhythmiaFp1-F3

F3-C3

C3-P3

P3-O1

Fp2-F4

F4-C4

C4-P4

P4-O2

Fp1-F7

F7-T3

T3-T5

T5-O1

Fp2-F8

F8-T4

T4-T6

T6-O2

1 sec 50 µV

Electrodecremental Seizure

MRI: Tuberous Sclerosis

Subependymal nodules Hamartoma

Bilateral Centrotemporal Spikes

Fp1-F3

F3-C3

C3-P3

P3-O1

fp2=f4

F4-C4

C4-P4

P4-o21 sec

50 µV

Absence: 3 Hz Spike and Wave

Myoclonic Seizure and Polyspike Wave

Jerk Jerk