Crea

ted b

y SY

MBI

OSE

- D.

Cab

rol -

J. Da

vid –

All R

ight

s Res

erve

d

AVENE CENTER34260 Avène-les-Bains – FrancePhone: +33 (0)4 67 23 41 87Fax: +33 (0)4 67 23 44 71www.avenecenter.comwww.eau-thermale-avene.com

POST-CANCER HYDROTHERAPY TREATMENT GUIDE

Practical InformationA Make an appointment with one of the doctors in the Hydrotherapy Center for your arrival medical consultation and prescription of your treatment course

Please contact Avene center to obtain updated list of doctors by phone at +33 (0)4 67 23 41 87 or Website www.avenecenter.com

- Provide medical information to the doctor before arrival- Contact your local Social Health insurance for reimbursement possiblities

2 Book your accommodation

The hotel and residential complex is here to accommodate you on-site. Phone number: +33 (0)4 67 23 44 45E-mail: val.dorb@pierre-fabre.com Other accommodations can be offered by the Avène Tourism OfficePhone number: +33 (0)4 67 23 43 38 or Website www.avene-orb-gavezon.com

3 Confirm your treatment registration

On the Website www.avenecenter.com, “Book my cure”, by post or by phone: +33 (0)4 67 23 41 87You will receive confirmation of your booking.

4 Organize your transport to Avène

Shuttle bus, Taxi, Car rental, please contact Avene center for more informationPhone number +33 (0)4 67 23 41 87 or Website www.avenecenter.comMore detailled information or assistance by contacting Avène Center team.

Certified in dermatology

POST-CANCER HYDROTHERAPY TREATMENT GUIDE 3

It all began around the age of enlightenment, in about a century which enlightened the world by means of its ideals as summarised by Condorcet: Reason, Humanity, Tolerance, etc. and which is still the motto of the Avène Hydrotherapy Center today.In 1736, the Marquis of Rocozels had a horse with a skin condition which was persistent and unpleasant. He followed his instinct which told him to drink water from the nearby spring every day and to bathe his entire body in it. A few days later, the news of his complete cure qualified as the “miracle of Avène water” spread throughout the region. The doctors of Montpellier and Paris, alerted, sent their first patients.They were not novices; the Faculty of Medicine of Montpellier had been founded in 1220, which makes it the oldest faculty of medicine in existence in the world…All of them confirmed the efficacy of Avène Thermal Water and recommended its use to the point such that in 1874, the National Academy of Medicine declared it a “Source of Public Interest”.

In 1975, Pierre Fabre, a tireless pharmacist and innovator was fascinated by this “sleeping beauty”. He decided to begin in-depth scientific studies in order to evaluate the potential properties and to understand its mode of action. Because even though the center is forgotten, its thermal spring water has not lost any of its qualities.

The many studies that have been conducted and the benefits observed by patients who have gone for hydrotherapy treatment at Avène Center provide a resounding confirmation. Avène Thermal Spring water is indeed a source of soothing water, the prefer-red spring for sensitive, damaged and fragile skin.

The Center, moreover, is the first Hydrotherapy Center specialised in dermatology to receive the certification “HACCP Aquacert Therma-lism” (in 2010 and renewed in 2013). The approach undertaken by the Avène Hydrotherapy Center to improve the quality of care, to ensure health safety and to provide satisfaction to their patients is therefore rewarded.

First hydrotherapy center in 2015 to receive a dis-tinction and recommendation by AFPRAL (French Association for the Prevention of Allergies, member of the European Foundation of Allergy). [Declared of public utility by the government (illegible)]

A Hydrotherapy Center with a rich history

POST-CANCER HYDROTHERAPY TREATMENT GUIDE 5

Founded before the 12th century, the village of Avène is nestled in the Orb valley, in the Haut-Lan-guedoc Regional Nature Park.Covered by woods and forests, this large park, 26,000 hectares, is carefully protected in an ideal setting for rest and relaxation. Its spectacular geographic location, the beautiful countryside, the lush vegetation, gorgeous sun-shine and the proximity of the Mediterranean all help make it a rare and precious paradise. The area is dotted with tiny old villages, full of his-toric charm and cultural heritage.In these beautiful surroundings, we find the implu-vium, the huge receptacle into which rainwater has flown for centuries, trickling down to eventually be-come our water source. This impluvium is the beginning of the Avène Spring Water’s underground journey. It is thought to take over 50 years to reach the source and to acquire all of its qualities and unique composition. The total sum of this knowledge

explains the soothing and anti-irritant properties of Avène Thermal Spring Water. They have been reported in several international scientific publications.

A beautifully preserved environment

WHAT HAS LONG BEEN KNOWN…

Avène Thermal Spring Water has a unique mineral content which is constant and qualitatively balanced.

• A low mineral content: dry residue 266 mg/litre. • Calcium bicarbonate and magnesium profile. • Calcium/magnesium ratio equal to 2. • Rich is silicates and trace elements. • A neutral pH: 7.5.

This specific mineral composition is an important factor for the pro-perties of Avène Thermal Spring Water.

…AND THAT RECENT DISCOVERIES HAVE TAUGHT US.

Our researchers in corporation with the Oceanographic Observa-tory of Banyuls-sur-Mer have demonstrated the existence of other active substances in the Thermal Spring Water which result from an original microflora called the “aqua. dolomiae” and comprise the biological signature of Avène Thermal Spring Water.

A Rare Spring Water with a dual signature…

Volume 25 Supplement 1 February 2011www.jeadv.com

EADVEUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (www.eadv.org)

JEADVJournal of the European Academy of Dermatology and Venereology

ISSN 0926-9959/1468-3083 (Online)

2009 Impact Factor:

2.787

Evidence-based Efficacyof Avène Thermal

Spring Water

47 3603

jdv_25_s1_oc.qxp 12/15/2010 11:32 AM Page 1

Proo

fs

38 39N° 44 - 2012 - ATOPIEDERMON° 44 - 2012 - ATOPIEDERMO CUS

ATOPIE DERMO CUS CUS CUS CUS CUS CUS CUS CUS CUS CUS CUS CUS CUS CUS CUS CUS CUS CUS CUS ATOPIEDERMO CUS CUS CUS CUS CUS CUS CUS CUS CUS CUS CUS CUS CUS CUS CUS CUS CUS CUS CUS CUS CUS

RésultatsL’application du baume Trixéra+ Sélectiose® sur épiderme reconstruit a stimulé la néosynthèse par les kératinocytes des différents lipides et précurseurs de li pides étudiés. Cet effet était supérieur à celui observé avec le témoin positif et le produit concurrent (Fig. 2). La quantification de la néosynthèse lipidique a permis de démontrer que cette stimulation était significativement supérieure à l’activité basale observée sur les épidermes non-traités (Fig. 3). La synthèse des acides gras estérifiés a été augmentée de manière particuliè-rement importante par une application préalable de Trixéra+ Sélectiose® (Fig. 4). Pour toutes les espèces lipidiques étudiés, Trixéra+ Sélectiose® s’est montré supérieur au concurrent (Fig. 3 et 4).

900

800

700

600

500

400

300

200

100

0

acides gras estérifiés

% s

ynth

èse

lipid

ique

ACTIVITE BASALE

*** p

POST-CANCER HYDROTHERAPY TREATMENT GUIDE 7

Today the diagnosis of cancer is synonymous with increasingly effective treatments (traditional surgery, radiological surgery, endoscopic surgery, radiotherapy, conventional chemotherapy, targeted therapy, immunotherapy, etc.).

These effective treatments enable increasingly long remissions under good conditions, but they also generate side effects, in particular, involving the skin, hair and nails.

Better understanding and controlling these side effects is essential to diminish their impact and to be able to continue to take advantage of the full efficacy of cancer treatments with upmost serenity.

You will no longer feel the same and you will experience the need to reconcile your body image and yourself.

In addition to the surgery itself, or even breast reconstruction which can leave unsightly or painful scars, cancer treatments often leave their “mark”. Three types of treatment can be differentiated:

M RADIOTHERAPY

Even when focused on the tumour, it can damage the skin. Radiation due to powerful x-rays can cause radio-dermatitis (skin burns) that are bothersome even though they are little intense and do not last.

M TRADITIONAL CHEMOTHERAPIES

Designed to inhibit the growth of tumour cells, they can also produce their effects on other cells, such as cells of the skin and hair, etc. So many bothersome side effects, but always temporary.

M NEW TARGETED THERAPIES

In order to produce an effect on all of the cells globally as traditional chemotherapies do, targeted therapies specifically target a problem or a discomfort presenting a precise anomaly and specific to the disease which affects it. Even targeted therapies can cause side effects.

Effective but demanding treatments

POST-CANCER HYDROTHERAPY TREATMENT GUIDE 9

“What is happiness?

Come here and this is will be

the first impression

that one has…”

Evelyne, patient at Avène

Everything here is designed to erase and to cushion trying times which follow surgery, chemotherapy or radiotherapy. Thermal spring water hydrotherapy is carefully planned so that your treatment is perfectly appropriate for your own case. Thermal water baths, hydro-massage showers, filiform showers and sprays, emollient cream wraps or soothing compresses with Avène Thermal Spring Water enable your skin to regain its comfort and feeling of well-being.

Oral mucus membrane conditions receive specific care with Avène Thermal Spring Water.

So many privileged moments which enable Avène Thermal Spring Water to gently circulate its soothing anti-irritant and softening properties.

Always on a “custom-made” basis and depending on your concerns or your plans, you will also have many workshops available for you:

A workshop on how to apply make-up, to teach the techniques of applying make-up to hide scars, but also to regain a luminous colour, beautiful eyebrows and a “revitalised” face.

- Dermo-cosmetic advice, knowing the proper ways for appropriate skin care to help it regain its suppleness and comfort.

- Appropriate exercises under the supervision of a physiotherapist to re-invigorate one’s body and improve mobility of the arms.

- Areas to meet people, moderated by a clinical psychologist, this is a place where people meet, listen and where each one can freely express, share his/her own experience.

- Dietary advice, by a pharmacist with a degree in medical dietetics, in order to help you follow an appropriate diet after treatment.

A significant improvement in beneficial effects on the skin thanks to hydrotherapy.

A clinical study conducted at the Center demonstrates the significant benefit of Avène thermal water therapy (patients who used thermal spring water therapy versus those who did not).

This study made it possible to demonstrate a significant improvement in Quality of Life, but also in the principal signs of skin discomfort such as dry skin, itching and indurated skin.

In addition in improvement in skin quality, an improvement in residual oedema is also observed and a significant impact on bodily image.

Benefits of avène hydrotherapy aftercancer treatment confirmed

“At Avène, there is a certain fragrance

of humanity. We all have our own body

envelope and Avène offers us a human

envelope. We wish to thank all of these

persons with smiling faces, and who provide

soothing types of care.”

Sophie, a patient at Avène Hydrotherapy Center

• A randomised controlled trial involving 6 hospital centres at the Avène Hydrotherapy Center on 68 female patients in complete remission. • Inclusion 1 to 5 weeks after treatment of breast cancer by Surgery/Chemotherapy/ Radiotherapy or by Chemotherapy/Surgery/Radio-therapy

-10

-30

-50

-70

-90

PruritusDry skin Skin induration

Spring Water Patients (35)

Non-Spring Water Patients (33)

NCI CTCAE specific scale (Criteria evolution)

POST-CANCER HYDROTHERAPY TREATMENT GUIDE11

While following a hydrotherapy treatment is engaging, it nevertheless allows you a certain amount of free time. And it would be a shame to go to Avène Center and be limited to the village, as charming as it may be. Because in fact it is full of precious charm, that of a bygone era. It exudes calm, soothing, like the Spring, its neighbour. But the soothing effect thus adds to the pleasure of discovery. Between two massages or two baths, everything is designed to entertain you, to delight you, to fascinate you and to help you to relax. Choose your favourite pass time. You can improve your backhand or your fore-hand stroke, the tennis court is within reach of your tennis racket. Your new friends invite you to join them and to play? The bowling alley and the mini-golf are within walking distance in the park. “It’s more fun to compete”… If you want to walk, all alone, as a couple or in a group ? Over 300 km of well indicated random trails await you. The best guides will be there for you…what scenery you will see!

And why not try your hand at trout fishing, this old dream that wells up in you…The clear water of the Orb River is at your feet and we have fishing rods for you! Golfer? In Lamalou, take advantage of a 9 hole golf course which is there for you with a true spectacle of greenery. Climber? You can attack the Mount Espinouse and the Escandorgue, whose name so well illustrates the south. And if you are surprised by a small gastronomical curiosity, think of the Roquefort caves, which no longer need any explanation and the wines of the nearby Hérault region. If you have a passion for exploring historical treasures, you can visit the Abbey of Sylvanès or the Cathar castles. Moving vestiges of the past, concentrated between Carcassone, Perpignan and Narbonne…

At the margin of the treatment: Discovering, Learning, Enjoying oneself

Finally, if you want to admire a pure masterpiece of modern civil engineering, then cross the Millau road bridge. As everyone who visits it says, the spectacular view will take your breath away.