PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 30
PRE – FEASIBILITY REPORT
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 31
INDEX
1.1 EXECUTIVE SUMMARY ......................................................................................................................... 34
1.2 SALIENT FEATURES OF THE PROJECT ............................................................................................ 34
1.3 PROPOSED PLANNING ......................................................................................................................... 40
2.0 INTRODUCTION OF THE PROJECT/ BACKGROUND INFORMATION .................................... 41
2.1 IDENTIFICATION OF PROJECT AND PROJECT PROPONENT ................................................... 41
2.2 BRIEF DESCRIPTION OF NATURE OF THE PROJECT .................................................................. 42
2.3 NEED FOR THE PROJECT AND ITS IMPORTANCE TO THE COUNTRY AND OR REGION . 42
2.4 DEMAND - SUPPLY GAP ....................................................................................................................... 42
2.5 IMPORTS VS. INDIGENOUS PRODUCTION ..................................................................................... 43
2.6 EXPORT POSSIBILITY ........................................................................................................................... 43
2.7 DOMESTIC/ EXPORT MARKETS ........................................................................................................ 43
2.8 EMPLOYMENT GENERATION (DIRECT AND INDIRECT) DUE TO THE PROJECT .............. 43
2.8.1 DIRECT EMPLOYMENT ....................................................................................................................................... 43
2.8.2 INDIRECT EMPLOYMENT ................................................................................................................................. 43
3.0 PROJECT DESCRIPTION ....................................................................................................................... 44
3.1 TYPE OF PROJECT INCLUDING INTERLINKED AND INTERDEPENDENT PROJECTS, IF
ANY. ............................................................................................................................................................ 44
3.2 LOCATION (MAP SHOWING GENERAL LOCATION, SPECIFIC LOCATION, AND PROJECT
BOUNDARY AND PROJECT SITE LAYOUT) WITH COORDINATES. ........................................ 44
3.3 DETAILS OF ALTERNATE SITES CONSIDERED AND THE BASIS OF SELECTING THE
PROPOSED SITE, PARTICULARLY THE ENVIRONMENTAL CONSIDERATIONS GIVEN
INTO SHOULD BE HIGHLIGHTED. .................................................................................................... 44
3.4 SIZE OR MAGNITUDE OF OPERATION ............................................................................................ 44
3.5 RAW MATERIAL (Quantity and Source), PRODUCT AND MODE OF TRANSPORT ............ 45
3.9 QUANTITY OF WASTES TO BE GENERATED (LIQUID AND SOLID) AND SCHEME FOR
THEIR MANAGEMENT/ DISPOSAL. ............................................................................................... 179
3.9.1 SOLID ....................................................................................................................................................................... 179
3.9.2 WASTE WATER.................................................................................................................................................... 180
3.10 SCHEMATIC REPRESENTATIONS OF THE FEASIBILITY DRAWING WHICH GIVE
INFORMATION OF EIA PURPOSE ................................................................................................... 188
4.0 SITE ANALYSIS ..................................................................................................................................... 189
4.1 CONNECTIVITY .................................................................................................................................... 189
4.2 LAND FORM, LAND USE AND LAND OWNERSHIP .................................................................... 189
4.2.1 LANDFORM ........................................................................................................................................................... 189
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 32
4.2.2 LAND USE ............................................................................................................................................................... 189
4.2.3 LAND OWNERSHIP ............................................................................................................................................ 189
4.3 TOPOGRAPHY (ALONG WITH MAP) ........................................................................................................ 190
4.4 EXISTING LAND USE PATTERN .. ................................................................................................... 190
4.5 EXISTING INFRASTRUCTURE ......................................................................................................... 190
4.5.1 BASIC AMENITIES ............................................................................................................................................. 191
4.6 SOIL CLASSIFICATION ....................................................................................................................... 191
4.7 CLIMATE ................................................................................................................................................ 191
4.8 SOCIAL INFRASTRUCTURE AVAILABLE ...................................................................................... 191
5.0 PLANNING BRIEF ................................................................................................................................ 191
5.1 PLANNING CONCEPT .. ....................................................................................................................... 191
5.2 POPULATION PROJECTION ............................................................................................................. 192
5.3 LAND USE PLANNING (BREAKUP ALONG WITH GREEN BELT ETC.) ................................. 192
5.4 ASSESSMENT OF INFRASTRUCTURE DEMAND (PHYSICAL AND SOCIAL) ....................... 193
5.5 AMENITIES/ FACILITIES ................................................................................................................... 193
6.0 PROPOSED INFRASTRUCTURE ...................................................................................................... 193
6.1 INDUSTRIAL AREA (PROCESSING AREA) ................................................................................... 193
6.2 RESIDENTIAL AREA (NON PROCESSING AREA) ............................................................................... 193
6.3 GREEN BELT ......................................................................................................................................... 193
6.4 SOCIAL INFRASTRUCTURE .............................................................................................................. 193
6.5 CONNECTIVITY (TRAFFIC AND TRANSPORTATION ROAD/ RAIL/ METRO/WATER
WAYS ETC.) ........................................................................................................................................... 194
6.6 DRINKING WATER MANAGEMENT (SOURCE AND SUPPLY OF WATER) ......................... 194
6.7 SEWERAGE SYSTEM ........................................................................................................................... 194
6.8 INDUSTRIAL WASTE MANAGEMENT ........................................................................................... 194
6.9 SOLID WASTE MANAGEMENT ........................................................................................................ 194
6.10 POWER REQUIREMENT AND SUPPLY/ SOURCE ...................................................................... 194
7.0 REHABILITATION AND RESETTLEMENT (R & R PLAN) ........................................................ 194
7.1 POLICY TO BE ADOPTED .................................................................................................................. 194
8.0 PROJECT SCHEDULE AND COST ESTIMATES ............................................................................. 195
8.1 LIKELY DATE OF START OF CONSTRUCTION AND LIKELY DATE OF COMPLETION . .. 195
8.2 ESTIMATED PROJECT COST ALONG WITH ANALYSIS IN TERMS OF ECONOMIC
VIABILITY OF THE PROJECT. .......................................................................................................... 195
9.0 ANALYSIS OF PROPOSAL .................................................................................................................. 195
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 33
9.1 FINANCIAL AND SOCIAL BENEFITS WITH SPECIAL EMPHASIS ON THE BENEFITS TO
THE LOCAL PEOPLE INCLUDING TRIBAL POPULATION, IF ANY, IN THE AREA. ........... 195
10.0 CONCLUSION......................................................................................................................................... 181
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 34
1.0 EXECUTIVE SUMMARY
1.1 EXECUTIVE SUMMARY
Lepro Herbals Private Limited was incorporated on 17th November 1991 and was set up on
17.04.1992 under the Companies Act 1956 and has been synonymous to Herbal Extracts
and their Purified derivatives in India located at Village - Jattipur, GT Road, Tehsil –
Samalkha, District - Panipat, Haryana.
The proposed expansion and change in product mix is for production capacity from
120kg/day to tune of 141kg/day. The total land area acquired by the unit is 33,254Sq.m.
The conversion of land for the industrial land use (CLU) has been done from Senior Town
Planner, Rohtak vide letter no.-Memo no. STP(R)/P.R.-I(3/5823 dated 29.11.2010. Copy is
enclosed as Annexure- XIII
The existing capital investment till 31.03.2017 is 3,537.98 Lacs by Lepro Herbals Pvt. Ltd.
The proposed expansion is expected to be to the tune of 870.00 Lacs in a phased manner
over a period of 5 years. Total project cost after expansion is 4407.98Lacs.
The existing products Herbal Extract & Its purified derivatives do not attract EIA Notification
2006 and its subsequent amendments thereafter as the products are simple herbal extract
and does not involve any synthesis. Now the expansion phase proposes semi synthesis in a
few products which attract the EIA Notification.
As per EIA Notification, published in Gazette of India, Extraordinary Part-II, Section-3, sub-
section (ii) of Ministry of Environment & Forest dated 14.09.2006 & subsequent
amendments, the proposed expansion and change in product mix of existing herbal extracts
and their purified derivatives for manufacturing of herbal extracts and active
pharmaceuticals ingredients falls in Activity 5(f), Category-A of “List of Projects or Activities
Requiring Prior Environmental Clearance”. As per the above notification, project will have to
obtain environmental clearance from MOEF&CC as the project falls on non notified
industrial plot with land is duly converted for industrial use.
1.2 SALIENT FEATURES OF THE PROJECT
Particulars Details
Coordinates NW NE
Latitude 290 17’57.22” N Latitude 290 17’57.16” N
Longitude 76 059’53.70” E Longitude 76 0 59’58.49” E
SE SW
Latitude 290 17’53.26” N Latitude 290 17’53.38” N
Longitude 77 00’1.34” E Longitude 76 059’44.14” E
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 35
Toposheet No. 53C/15, 53G/3
Existing Production
Capacity
PURE HERBAL PRODUCTS MANUFACTURED IN THE FACTORY
S.
No
Product Raw Material
( Herb)
Annual
Quantity of
Herb used for
Extraction
( Tons )
Quantity of Final
Product
(Kg/Annum )
1. Boswellia
Seratta Extract Boswelia Gum
10 1000
2. Sambrani
Extract 1000
3. Coleus 97% Coleus Roots 80 200
4.
Selina Extract
Japanese
Atractylodes 60
200
5. Andographolide Kalmeg 5 100
6.
Anogessius
Anogessius
Seeds 3
200
7. Passiflora
Extract
Passiflora
Leaves 5
1000
8. Titrated Extract
of Centella
Centella
Leaves 250
4000
9. Valerian
Officinalis
Extract
Valerian Roots
13
4000
10. 18 Beta
Glyhetitinic Acid
Glycrrihizia
Glabra
50 500
11. Enoxolone 400 4000
12. De
Glycrrhizinated
Liquorice ( DGL
)
40
1000
13. Di Potassium
Glycrrhizinate
( DPG )
10
1000
14. Ammonium
Glycrrhizinate 74
2500
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 36
( MAG )
15. Acetyl
Glycrrhitinic
Acid (AGA)
550
-
8500
16. Glabradin ( 20
% ) 500
17. Glabradin ( 40
% )
18. Glabradin ( 60
% )
19. Glabradin ( 97
% )
20. Gingerol Ginger Roots 2 200
21. Escin Horse Chest
Nut
125 2500
22. Horse Chest Nut
Extract 4
500
23. Nutmeglignum Nutmeg Seeds 8 300
24.
Ruscogenin
Butchers
Broom 20
100
25. Euphorbia
Prostrata
Ethanolic dry
Extract
Euphorbia
Prostrata 30
1000
26. Humulus
Lupulus
Humulus
lupulus 0.5
100
27. Hydro tyrasol Olive leaves 6.5 100
28. Policosanol Sugar can
wax(Mud) 1
100
29. Tobacco
Absolute
Tobacco
absolute crude -
200
Total 1747 34,800
Proposed production
Capacity
PURE HERBAL PRODUCTS TO BE MANUFACTURED IN THE FACTORY
S.
No
Product Raw Material
( Herb)
Annual
Quantity of
Herb used for
Extraction (
Quantity of Final
Product
(Kg/Annum )
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 37
Tons )
1. Turmeric Extact Turmeric
Roots 2 500
2. Pomegranate
Extract
Pomegranate
Peels 2 500
3. Grape Seed
Extract
Grape Seeds 2 400
4. Nicotine Tobacco Dust 125 1000
5. Nicotine
Polacrilex
0 500
6. Pygeum Extract Prunus
Africana 20 100
7. Milk Thistle
Extract
Cardace Seeds 10 500
8. Red Clover
Extract
Red Clover 2 200
9. Nicotine Di
Hydrate Di
Tartrate
Tobacco Dust
0 500
10. TOTAL 163 4200
SEMI SYNTHETIC PRODUCTS PROPOSED TO BE MANUFACTURED IN THE
FACTORY
1. Hyoscine Butyl
Bromide
Dubosia
Leaves
In house
800
2. Hyoscine
Hydrobromide 100
3. Hyoscamine
Sulfate 50
4. Atropine Sulfate 700
5. Cimetropium
Bromide 50
6. Met
Scopolamine
Bromide 100
7. Homa Tropine
Methyl Bromide
Tropine 1
100
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 38
8. Reserpine Rauwolfia
Vomitoria 30
100
Total 31 2000
Estimated project cost Project Cost Amount (In Lacs)
Existing 3,537.98
Proposed 870.00 (Expansion)
Total 4407.98
Man Power Man Power in
Nos
Existing Proposed
198 34 (Expansion)
Total 232
Elevation Highest –237MSL; Lowest 232MSL.
Land use S.No Particulars Exiting
Area
(SQM)
Proposed
Area
(SQM)
Total
Area
(SQM)
Percentage
(%)
1 Buildings / Office /
Warehouses /QC/R&D /
Workshop/ DG Room
/Manufacturing
plants/ETP/RO
Plant/Boiler
18163 1400 19,563 58.83
2 Paved area/
Roads/corridors/parking
4569 301 4,870 14.64
3 Green belt 6700 -- 6,700 20.15
4 Open area 3822 -1701 2,121 6.38
TOTAL 33,254 -- 33,254 100%
Nearest Habitation/
Town
Jattipur-500m (E)
Nearest Airport Delhi International Airport –81.50 Km, S
Nearest Highway S. No. Particulars Connectivity Distance (m) Direction
(From Project Boundary)
1. NH-1 20m W S
2. SH-16 7.15 Km NW SW
Source: All distances are taken with respect to Google Earth.
Nearest railway track
from project boundary
Railway station - 2.59 Km, NNW
Power supply The unit has a total connected load of 810 kVA which is being supplied Haryana
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 39
State Electricity Board
Existing D.G. Sets
500 kVA (3 Nos)
320 kVA (1No)
Proposed DG Set
No additional DG set is proposed.
Nearest Dispensary and
Govt. Hospital
Govt. Dispensary, Jattipur-632m E
Nearest Educational
facility
Govt. School Jattipur -645m E
Water demand ,supply
and Waste water
generation after
expansion with product
mix
Description Water
Consumption
KLD
Waste Water
Generation (KLD)
Effluent Treatment
& disposal facility
Domestic use
Domestic 9 6 To STP (Cap.15KLD)
Industrial Use
Process 18 16 To ETP (Cap.35KLD)
followed by ZLD
Cooling tower 43 (15 KL Fresh
make up water
+ 28 KL treated
water)
5 To ETP followed by
RO for further use in
process
Boiler 30 4
RO reject 8 4 For flushing after
treatment
4 To ETP followed by
RO for further use in
cooling tower.
Horticulture /
Green Area
Development
10 --
Fresh Water
Demand
80
Recycled water 28
Total water
consumption
108
Source: Existing bore well.
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 40
Nearest tourist places None within the 10 km radius of the project site
Defense installations None within the 10 km radius of the project site
Archeological Features None within the 10 km radius of the project site
Ecological sensitive
zones
None within the 10 km radius of the project site
Nearest Forests None within the 10 km radius of the project site
Nearest streams/
rivers/ water bodies
(from project
boundary) Source: All distances are taken with respect to Google Earth.
S. No. Particulars Distance (Km) Direction
(From Project Boundary)
1. Western Yamuna canal 3.7 W
Seismic zone As per the 2002 Bureau of Indian Standards (BIS) seismic zone map of India, the
region comes under Zone-III. This zone is called the Moderate Zone and covers
areas liable to MSK VIII.
1.3 PROPOSED PLANNING
Company : Lepro Herbals Pvt. Ltd.
Project Cost : Rs. 870.0Lacs
Production : As given below:-
PURE HERBAL PRODUCTS TO BE MANUFACTURED IN THE FACTORY
S.
No
Product Raw Material
( Herb)
Annual Quantity of Herb
used for Extraction
( Tons )
Quantity of Final
Product
(Kg/Annum )
1. Turmeric Extact Turmeric Roots 2 500
2. Pomegranate Extract Pomegranate
Peels 2 500
3. Grape Seed Extract Grape Seeds 2 400
4. Nicotine Tobacco Dust 125 1000
5. Nicotine Polacrilex 0 500
6. Pygeum Extract Prunus Africana 20 100
7. Milk Thistle Extract Cardace Seeds 10 500
8. Red Clover Extract Red Clover 2 200
9. Nicotine Di Hydrate Di
Tartrate
Tobacco Dust 0 500
10. TOTAL 163 4200
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 41
SEMI SYNTHETIC PRODUCTS PROPOSED TO BE MANUFACTURED IN THE FACTORY
1. Hyoscine Butyl Bromide Dubosia Leaves
In house
800
2. Hyoscine Hydrobromide 100
3. Hyoscamine Sulfate 50
4. Atropine Sulfate 700
5. Cimetropium Bromide 50
6. Met Scopolamine
Bromide 100
7. Homa Tropine Methyl
Bromide
Tropine 1
100
8. Reserpine Rauwolfia
Vomitoria 30
100
Total 31 2000
2.0 INTRODUCTION OF THE PROJECT/ BACKGROUND INFORMATION
2.1 IDENTIFICATION OF PROJECT AND PROJECT PROPONENT
Lepro Herbals Private Limited was incorporated on 17th November 1991 and was set up on
17.04.1992 under the Companies Act 1956 and has been synonymous to Herbal Extracts
and their Purified derivatives in India located at Village - Jattipur, GT Road, Tehsil –
Samalkha, District - Panipat, Haryana.
The proposed expansion and change in product mix is for production capacity from
9MT/day to tune of 36MT/day. The total land area acquired by the unit is 33,158Sq.m. The
conversion of land for the industrial land use (CLU) has been done from Senior Town
Planner, Rohtak vide letter no.-Memo no. STP(R)/P.R.-I(3/5823 dated 29.11.2010. Copy is
enclosed as Annexure- XIII
The existing capital investment till 31.03.2017 is 3,537.98 Lacs by Lepro Herbals Pvt. Ltd.
The proposed expansion is expected to be to the tune of 870.00 Lacs in a phased manner
over a period of 5 years. Total project cost after expansion is 4407.98Lacs.
Name and address of
the Applicant
Lepro Herbals Pvt. Ltd.
Authorized Signatory
Sunil Malik
Vice –President Supply Chain management
G.T. road, Village - Jattipur, Tehsil - Samalkha, District- Panipat, Haryana - 132 101
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 42
2.2 NATURE OF THE PROJECT
Lepro Herbals Private Limited, Panipat, Haryana proposes expansion and change in the
product mix for manufacturing of herbal extracts and active pharmaceuticals ingredients.
The proposed expansion with change in product mix is planned in existing plant area of 33,
254Sq.m. No additional land is required.
2.3 NEED FOR THE PROJECT AND ITS IMPORTANCE TO THE COUNTRY AND OR REGION
India is a developing country with varied geographical locations resulting in climate change.
Changing climate and changing lifestyles of people globally is resulting in many varied types
of diseases and disorders which is effecting people globally. Throat infection), asthma, and
lifestyle diseases like Cholesterol, Heart diseases, constipation, diabetes etc are very
common phenomena. Few other reasons like stored water, uncovered litter, dirty places,
unhealthy living habits, unhealthy eating habits, pollution, water contamination and more
require medicines. Thus, the proposed production contributes in prevention, cure and
recovery of ailments and diseases. Drug manufacturing units produces lifesaving drugs
which helps the patients recover faster and result in no medicinal side effects. Phyto APIs
are a preferred option for varied ailments as they are plant extracts and have no Toxic effect
and are regarded SAFE.
2.4 DEMAND - SUPPLY GAP
By 2050, it is expected that India will be the most populous country with an estimated
population of 1.6 billion. By 2025, it is being viewed that 189 million Indians will be 60 or
older up from about 63 million in year 2004. This projection indicates the demand for
pharmaceutical drugs will rise in coming years.
Herbal Extract & their Purified Derivatives, Bulk Drugs & its Intermediates will be
manufactured largely comprising of anticancer, anti-parasitic, anti-inflammatory, laxatives &
pain reliever drugs. Treatment of various regular and life style diseases like chronic disease,
acute pain, congestive heart failure, type 2 diabetes, constipation, osteoarthritis, and
management of hypertension.
The industry is working in the field of Herbal Extract and their Purified Derivatives to fulfill
the ever increasing international demand of “safe“medicines.
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 43
2.5 IMPORTS VS. INDIGENOUS PRODUCTION
There will be Indigenous production in the entire activity. As most of the products are herbal
and majority of all the raw material demand is being met from domestic market only but few
specific herbs is being imported owing to specific geographic locations.
The pharmaceutical industry in India meets around 70% of the country's demand for bulk
drugs, drug intermediates, pharmaceutical formulations, chemicals, tablets, capsules, orals
and injectable.
2.6 EXPORT POSSIBILITY
The product is prospecting exports.
2.7 DOMESTIC/ EXPORT MARKETS
Indian drug industry is well developed for the manufacture of many bulk drugs. At present
India is self sufficient and technologically at par with the best in the world. Indian pharma
industry is unit wise small and in fact many units are in small scale sector. Almost 55% of
the domestic production is contributed by small scale units. Production during 1990-91 was
reported to be 750 tons.
2.8 EMPLOYMENT GENERATION (DIRECT AND INDIRECT) DUE TO THE PROJECT
2.8.1 DIRECT EMPLOYMENT
Presently the work force of this unit is 198. Highly qualified and trained manpower is
required for running operations in the plant which are already available. Regular trainings
are imparted to personnel to keep them updated with the requirements of process. An
increase of 34 manpower is proposed with the expansion in a phased manner.
2.8.2 INDIRECT EMPLOYMENT
Increase in supporting industries such as packaging, printing etc.
Increase in Supply chain
Increase in Distribution Channel both- National and International
Carrier goods
Government of India Taxes
Minor increase in telecommunication, couriers etc.
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 44
3.0 PROJECT DESCRIPTION
3.1 TYPE OF PROJECT INCLUDING INTERLINKED AND INTERDEPENDENT PROJECTS, IF
ANY.
No interlinked project. Proposed expansion and change of product mix is planned from
120kg/day to 141kg/Day in area of 33, 254Sq.m. Sq.m. in existing plant premises. No
additional land is required.
3.2 LOCATION (MAP SHOWING GENERAL LOCATION, SPECIFIC LOCATION, AND PROJECT
BOUNDARY AND PROJECT SITE LAYOUT) WITH COORDINATES.
It is located at G.T. Road, Village- Jattipur, Tehsil Samalkha, District- Panipat, Haryana. The
project site falls in Survey of India Toposheet No. 53C/15, 53G/3..
The geographical location with respect to boundary pillars of the project are:-
Table 2: Geographical Position of the Boundary Pillars
NW NE
Latitude 290 17’57.22” N Latitude 290 17’57.16” N
Longitude 76 059’53.70” E Longitude 76 0 59’58.49” E
SE SW
Latitude 290 17’53.26” N Latitude 290 17’53.38” N
Longitude 77 00’1.34” E Longitude 76 059’44.14” E
The map showing location of the project site is enclosed as Annexure – XII.
3.3 DETAILS OF ALTERNATE SITES CONSIDERED AND THE BASIS OF SELECTING THE
PROPOSED SITE, PARTICULARLY THE ENVIRONMENTAL CONSIDERATIONS GIVEN
INTO SHOULD BE HIGHLIGHTED.
No alternative site was examined as the proposed expansion and change in product mix is
coming within the existing premises.
3.4 SIZE OR MAGNITUDE OF OPERATION
The size and magnitude of the project area is as given below:-
Table 3: Size or Magnitude
S. No. Particulars Details
1. Area 33,254 Sq.m.
2. Production (After expansion and
change in product mix)
The proposed production capacity is 141kg/day
3. Total Man Power (Nos.) 232Nos.( Existing -198, Proposed -34)
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 45
3.5 RAW MATERIAL (Quantity and Source), PRODUCT AND MODE OF TRANSPORT
RAW MATERIAL SOURCING AND STORAGE
Lepro Herbals dependence on agriculture and its produce is complete and total. All the
products of the company which command sustained high demand are produced from
agriculture and herbs. The raw materials /starting herbs used in the extraction and
production of the above listed extracts under reference and report are to be sourced
indigenously from various parts of the country as these harmonize topographically and
geographically.
The unit has 3 very large warehouses located on the premises which are used for the storage
of herbs. Being an agricultural produce with specific time of sourcing, the storage gains even
more importance for continuous supply of end product to the market.
WHO- GOOD MANUFACTURING PRACTICES and their standard protocols for WAREHOUSING
are adhered to focused heavily of safety and pest free storage.
MANUFACTURING PROCESS AND MATERIAL BALANCE OF THE COMPANYS PRODUCTS
The standardized extraction and purification process is detailed below in a flow chart with
option for minor variations which would be product specific. As it has been specified in the
point No 1.7 where all the products manufactured have been listed. The manufacturing
process and material balance with Raw Material details are appended below in detail.
A. PURE HERBAL PRODUCTS MANUFACTURED IN THE FACTORY
1. Boswellia Extract
Boswellia serrata (gum)
RRRRRRRRRRROOTroots
Extraction
Boswellia Extract
Molecular Formula: C30H46O4
Molecular Weight: 470.68
MOLECULAR WEIGHT
Boswellia Extract
Molecular Formula: C32H48O5
Molecular Weight: 512.731 g/mol
MOLECULAR WEIGHT
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 46
Brief description of the manufacturing process:
Boswellia extract is produced by extraction from Boswellia serrata gum. The extract has been
further purified by Phase exchange to give Boswellia extract.
List of Raw Materials:
Name of Raw Material Storage at the site
Boswellia serrata gum Warehouse
MDC Solvent Storage Tanks
Methanol Solvent Storage Tanks
Caustic potash Store
Hydro Chloric acid Solvent Storage Tanks
MATERIAL BALANCES SHEETS FOR BOSWELLIA EXTRACT
STAGE-1, STAGE-2
S. No. Raw Material Input/Kg of Product (Kg)
1 Boswellia serrata gum 800
2 Methanol 12000
Total: 12800
Sr. No. Output/Kg of product (Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Methanol Concentrated syrup - - 400 0 400
2 Methanol - 60 11540 - 11600
3 Exhaust herb - - - 800 800
4 Third party mixed solvent - - - -
Total: - - - - 12800
STAGE-3 & STAGE-4
Sr. No. Raw Material Input/Kg of Product (Kg)
1 Methanol Concentrated syrup 400
2 Caustic potash 50
3 Water 1000
6 MDC 2400
Total: 3850
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 47
1 Aqueous layer of material - 1200 0 1200
2 MDC residue - - - 250 250
3 MDC - 50 2350 - 2400
4 Water - - - - -
5 Third party mixed solvent - - - - -
Total: - 3850
STAGE-5 & STAGE-6
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Methanol Concentrated syrup 1200
2 HCl 75
3 MDC 2660
4 Methanol 480
Total: 4415
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Boswellia Extract - 150 0 150
2 MDC - 50 2610 - 2660
3 Methanol - 30 450 - 480
4 Exhaust aqueous layer 1125 - - - 1125
5 Third party mixed solvent - - - - -
Total: - 4415
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 48
Figure – 1: Raw Material, Material Balance and process flow chart of Boswellia Extract
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 49
2. Sumbrani Extract
Brief description of the manufacturing process:
Sambrani extract is produced by extraction from Boswellia serrata gum. The extract has been
further purified by Phase exchange to give Sambrani extract.
List of Raw Materials:
Name of Raw Material Storage at the site
1. Boswellia serrata gum Warehouse
2. MDC Solvent Storage Tanks
3. Methanol Solvent Storage Tanks
4. Caustic potash Store
5. Hydro Chloric acid Solvent Storage Tanks
MATERIAL BALANCES SHEETS FOR SAMBRANI EXTRACT:
STAGE-1, STAGE-2
Sr. No. Raw Material Input/Kg of Product (Kg)
1 Boswellia serrata gum 800
2 Methanol 12000
Total: 12800
Sr. No. Output/Kg of product (Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Methanol Concentrated syrup - - 400 0 400
2 Methanol - 60 11540 - 11600
Boswellia serrata (gum)
RRRRRRRRRRROOTroots
Extraction
Sambrani Extract
Molecular Formula: C30H46O4
Molecular Weight: 470.68
MOLECULAR WEIGHT
Sambrani Extract
Molecular Formula: C32H48O5
Molecular Weight: 512.731 g/mol
MOLECULAR WEIGHT
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 50
3 Exhaust herb - - - 800 800
4 Third party mixed solvent - - - -
Total: - - - - 12800
STAGE-3 & STAGE-4
Sr. No. Raw Material Input/Kg of Product (Kg)
1 Methanol Concentrated syrup 400
2 Caustic potash 50
3 Water 1000
6 MDC 2400
Total: 3850
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Aqueous layer of material - 1200 0 1200
2 MDC residue - - - 250 250
3 MDC - 50 2350 - 2400
4 Water - - - - -
5 Third party mixed solvent - - - - -
Total: - 3850
STAGE-5 & STAGE-6
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Methanol Concentrated syrup 1200
2 HCl 75
3 MDC 2660
4 Methanol 480
Total: 4415
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Sumbrani Extract - 150 0 150
2 MDC - 50 2610 - 2660
3 Methanol - 30 450 - 480
4 Exhaust aqueous layer 1125 - - - 1125
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 51
5 Third party mixed solvent - - - - -
Total: - 4415
Figure – 2: Raw Material, Material Balance and process flow chart of Sumbrani Extract
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 52
3. Coleus 97%
Brief description of the manufacturing process:
Coleus Extract is extracted from coleus roots and is further undergo concentration, phase
exchange, lixivation, 1st Toluene lixivation , Column Purification ,2ND toluene lixivation,
Purification & lixivation and final column purification and crystallization to give coleus
extract 97%.
List of Raw Materials:
Name of Raw Material Source Storage at the site
6. Coleus roots Warehouse
7. Methanol B.K.Sales Solvent Storage Tanks
8. Water In House Water system
9. Methylene chloride B.K.Sales Solvent Storage Tanks
10. Hexane Pon pore Warehouse
11. Toluene Pon pore Warehouse
12. Activated alumina Real Chemsys Warehouse
13. Ethyl acetate Jubliant life sciences Warehouse
14. Chloroform B.K.Sales Solvent Storage Tanks
MATERIAL BALANCES SHEETS FOR COLEUS EXTRACT
STAGE - 1 & 2
S. No. Raw Material Input/Kg of Product(Kg)
1 Coleus roots 10000
2 Methanol 76800
COLEUS FORSKLII ROOTS Extraction
COLEUS EXTRACT AS FORSKOLIN Molecular Formula: C22H34O7
Molecular Weight: 410.51
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 53
Total: 86800
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Coleus syrup - - 5000 - 5000
2 Exhaust Herbs - - - 10000 10000
3 Third party mixed
solvent
4800
67000
71800
Total: 86,800
STAGE - 3
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Coleus syrup 5000
2 water 1000
3 Methylene Chloride 11704
Total: 17704
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 concentrated
syrup
- - 700 - 700
2 Aq. Layer 5300 - - 0 5300
3 Third party mixed
solvent
1064
10640
11704
Total: 17,704
STAGE - 04-06
Sr. No. Raw Material Input/Kg of Product(Kg)
1 concentrated syrup 700
2 Hexane 693
3 Toluene 430
Total: 1823
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Dry material - - 100 600 700
2 Hexane 64 629 0 693
3 Toluene 29 401 430
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
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APRIL’2018 54
3 Third party mixed
solvent
0 0
0
Total: 1,823
STAGE - 07-09
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Dry material 100
2 Activated alumina 450
2 Ethyl acetate 5400
3 Toluene 129
Total: 6079
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Dry material - - 35 65 100
2 Ethyl acetate 50 5350 0 5400
3 Toluene 13 116 129
4 Activated alumina 450 450
5 Third party mixed
solvent
0 0
0
Total: 6,079
STAGE - 10-13
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Dry material 35
2 Activated alumina 100
3 Ethyl acetate 1260
4 Hexane 726
5 chloroform 1350
Total: 3471
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Dry material
(Final)
- - 25 10 35
2 Ethyl acetate 60 1200 0 1260
3 Chloroform 40 1310 1350
4 Hexane 50 676 726
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 55
5 Activated alumina 100 100
6 Third party mixed
solvent
0 0
0
Total: 3,471
Figure – 3: Raw Material, Material Balance and process flow chart of Coleus 97%
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 56
4. Selina Extract
Brief description of the manufacturing process:
Selina Extract is extracted from the Japanese Atractylodes roots and is further purified through
Phase Exchange, Column Chromatography and Purification.
List of Raw Materials:
Name of Raw Material Source Storage at the site
Japanese Atractylodes Namyana Herb Warehouse
Methanol B. K. Sales corporation Solvent Storage Tanks
Hexane V.S. Interchem Pvt Ltd Solvent Storage Tanks
Ethyl acetate Jubilant life sciences Ltd Solvent Storage Tanks
Silica gel (200-400) Swambe chemicals Warehouse
MATERIAL BALANCES SHEETS FOR SELINA EXTRACT:
STAGE-1
Sr. No. Raw Material Input/Kg of Product (Kg)
1 Japanese Atractylodes roots 10000
2 Methanol 100000
Total: 110000
Sr. No. Output/Kg of product (Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Concentrate Syrup - - 4800 - 4800
2 Exhaust Herb - - - 10000 10000
3 Methanol - 100 95100 - 95200
Total: - 110000
Japanese Atractylodes Roots
Selina Extract Molecular Formula: C15H22O
Molecular Weight: 218.34
Extraction & Purification
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
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APRIL’2018 57
STAGE-2
Sr. No. Raw Material Input/Kg of Product (Kg)
1 Concentrate Syrup 4800
2 Hexane 7920
Total: 12720
Sr. No. Output/Kg of product (Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Syrup 4080 - 720 - 4800
2 Hexane - 92 7828 - 7920
Total: - 12720
STAGE-3
Sr. No. Raw Material Input/Kg of Product (Kg)
1 Syrup 720
2 Hexane 7920
3 Ethyl acetate 300
Total: 8940
Sr. No. Output/Kg of product (Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Syrup 510 - 210 - 720
2 Hexane - 92 7828 - 7920
3 Ethyl acetate - 50 250 - 300
Total: - 8940
STAGE-4
Sr. No. Raw Material Input/Kg of Product (Kg)
1 Syrup 210
2 Hexane 19800
3 Ethyl acetate 500
4 Silica Gel(200-400) 400
Total: 20910
Sr. No. Output/Kg of product (Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Syrup 150 - 60 - 210
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
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APRIL’2018 58
2 Hexane - 100 19700 - 19800
3 Ethyl acetate - 60 440 - 500
4 Silica Gel(200-400) - - - 400 400
Total: 20910
STAGE-5
Sr. No. Raw Material Input/Kg of Product (Kg)
1 Syrup 60
Total: 60
Sr. No. Output/Kg of product (Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Selina Extract 28 32 - 60
Total: 28 32 - 60
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
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ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 59
Figure – 4: Raw Material, Material Balance and process flow chart of Selina Extract
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
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ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 60
5. Andographolide
Brief description of the manufacturing process:
Andrographolide is extracted from the leaves of Kalmegh and is further purified through
Lixiviation.
List of Raw Materials:
Name of Raw Material Source Storage at the site
Kalmegh leaves - Warehouse
Ethyl Acetate Jubilant life sciences Ltd Solvent Storage Tanks
Hexane V.S. Interchem Pvt Ltd Solvent Storage Tanks
Denatured Spirit Ashoka distillery Solvent Storage Tanks
MATERIAL BALANCES SHEETS FOR ANDROGRAPHOLIDE:
STAGE-1 & STAGE-2
S. No. Raw Material Input/Kg of Product (Kg)
1 Kalmegh Leaves 600
2 Ethyl Acetate 5000
Total: 5600
Sr. No. Output/Kg of product (Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Concentrate Syrup - - 40 - 40
2 Exhaust Herb - - - 600 600
3 Ethyl Acetate - 60 4900 - 4960
Total: - 5600
Kalmegh leaves Extraction & Lixiviation
Andrographolide
Molecular Formula: C20H30O5
Molecular Weight: 350.46
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
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STAGE-3
S. No. Raw Material Input/Kg of Product (Kg)
1 Concentrate syrup 40
2 Hexane 300
Total: 340
Sr. No. Output/Kg of product (Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Material 25 - 15 - 40
2 Hexane - 25 275 - 300
Total: - 340
STAGE-4
S. No. Raw Material Input/Kg of Product (Kg)
1 Material 15
2 Denatured Sprit 300
3 Decamax 5
Total: 320
Sr. No. Output/Kg of product (Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Andrographolide - - 13 7 20
2 Denatured Spirit - 25 275 - 300
Total: - 20 293 7 320
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 62
Figure – 5: Raw Material, Material Balance and process flow chart of Andographolide
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
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ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 63
6. Anogeissus
Brief description of the manufacturing process:
Anogeissus is produced by extraction from Anogeissus Leiocarpus bark. The extract has been
further purified by Column purification to give Anogeissus.
List of Raw Materials:
Name of Raw Material Storage at the site
Anogeissus Leiocarpus bark Warehouse
Methanol Solvent Storage Tanks
Silica gel Store
Ethyl acetate Solvent Storage Tanks
MATERIAL BALANCES SHEETS FOR ANOGEISSUS:
STAGE-1
S. No. Raw Material Input/Kg of Product(Kg)
1 Anogeissus Leocarpus bark 800
2 Methanol 19200
Total: 20000
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Concentrated syrup - - 320 0 320
2 Methanol - 100 18780 - 18880
3
Exhaust herb - - 800 800
Anogeissus Leocarpus bark
RRRRRRRRRRROOTroots
Extraction
Anogeissus
Molecular Formula: Molecular Weight:
MOLECULAR WEIGHT
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
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APRIL’2018 64
Total: - 20000
STAGE-2
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Concentrated syrup 320
2 Silica gel 700
3 Methanol 4500
4 Ethyl acetate 18000
Total: 23520
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Anogeissuse - 64 0 64
2 Methanol - 50 4450 0 4500
3 Ethyl acetate - 100 17900 - 18000
4 Solid waste - 956 956
Total: - 23520
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 65
Figure – 6: Raw Material, Material Balance and process flow chart of Anogeissus
7. Passiflora Extract
Passiflora leaves Extraction
Passion Flower dry extract (Active ingredients Isobitexin) Molecular Formula: C21H20O10
Molecular Weight: 432.38 g/mol
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 66
Brief description of the manufacturing process:
Passion Flower dry extract is extracted from the Passiflora Leaves and is standardized with
maltodextin
List of Raw Materials:
Name of Raw Material Source Storage at the site
Passiflora Leaves V.R Pusalkar Warehouse
Acetone V.S.Interchem pvt Ltd Solvent Storage Tanks
Hexane V.S.Interchem pvt Ltd Solvent Storage Tanks
Maltodextin Aristio chemicals Warehouse
Silicon dioxide BS Mehra & Sons Warehouse
MATERIAL BALANCES SHEETS FOR PASSION FLORA DRY EXTRACT
STAGE-1 & STAGE-2
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Passiflora Leaves 1800
2 Methanol 20000
Total: 21800
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Concentrate syrup -- -- 300 -- 300
2 Husk -- -- -- 1800 1800
3 Acetone 100 19600 -- 19700
Total: 21800
STAGE-3 & STAGE-4
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Concentrate syrup 300
2 Hexane 600
Total: 900
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Syrup 150 -- 150 -- 300
2 Hexane -- 50 550 -- 600
Total: 900
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 67
STAGE-5 & STAGE-6
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Syrup 150
2 Maltodextin 150
3 Silicon dioxide 10
Total: 310
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Passiflora flora dry extract -- 16 294 -- 310
Total: 310
Figure – 7: Raw Material, Material Balance and process flow chart of Anogeissus
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 68
8. Titrated Extract of Centella
Brief description of the manufacturing process:
Titrated extract of Centella Asiatica is extracted from the leaves of Centella Asiatica and is
further purified through Phase Exchange & Crystallization.
List of Raw Materials:
Name of Raw Material Storage at the site
Centella Asiatica Leaves Warehouse
Methanol Solvent Storage Tanks
MATERIAL BALANCES SHEETS FOR TITRATED EXTRACT OF CENTELLA ASIATICA :
STAGE-1 & STAGE-2
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Centella Asiatica leaves 3000
2 Methanol 15680
3 Water 8400
Total: 27080
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
Centella Asiatica Leaves Extraction
Titrated extract of Centella Asiatica
Asiaticoside Molecular Formula: C48H78O19
Molecular Weight: 959.133
Madecassic acid
Molecular Formula: C30H48O6
Molecular Weight: 504.708
Asiatic acid
Molecular Formula: C30H48O5
Molecular Weight: 488.7
+ +
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 69
1 Concentrate Syrup - - 4000 - 4000
2 Exhaust Herb - - - 3000 3000
3 Methanol - 80 15000 - 15080
4 Water 400 - 4600 - 5000
Total: - 27080
STAGE-3
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Concentrate Syrup 4000
2 Chloroform 9000
Total: 13000
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Syrup - - 4000+100
=4100
- 4100
2 Chloroform - 100 8800 - 8900
Total: 13000
STAGE-4 (For Asiaticoside)
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Syrup 4000
2 Sodium Bicarbonate 250
3 Butanol 12000
4 Water 4800
Total: 21050
Sr. No. Output/Kg of product (Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Asiaticoside Crude 3800 - 200 - 4000
2 Sodium Bicarbonate 250 - - - 250
3 Butanol - 80 11920 - 12000
4 Water 4800 - - - 4800
Total: 21050
STAGE-5 (For Asiaticoside)
Sr. No. Raw Material Input/Kg of Product(Kg)
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 70
1 Asiaticoside Crude 200
2 Methanol 400
3 Water 500
4 HCL 3
Total: 1103
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Material - 143 900+60 - 1103
2 Methanol - - - - -
3 Water - - - - -
4 HCL - - - - -
Total: - 1103
Remarks:- 900 ltr Use for hydrolysis to produce Genin.
STAGE-5
Sr. No. Raw Material Input/Kg of Product (Kg)
1 Material 60
2 Methanol 720
3 Activated Carbon ICP-20 3
4 Decamax 3
5 Water 100
Total: 886
Sr. No. Output/Kg of product (Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Material 20 - 40 - 60
2 Methanol - 40 680 - 720
3 Activated Carbon ICP-20 - - - 3 3
4 Decamax - - - 3 3
5 Water - 30 70 - 100
Total: 886
STAGE-6
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Material 40
2 Methanol 500
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 71
3 Activated Carbon ICP-20 3
4 Decamax 3
5 Water 50
Total: 596
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Asiaticoside Pure 8 - 32 - 32
2 Methanol - 20 480 - 500
3 Activated Carbon ICP-20 - - - 3 3
4 Decamax - - - 3 3
5 Water - 15 35 - 50
Total: 596
STAGE-7(For Genin)
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Material taken from Stage 2 100
2 Acetone 500
3 Water 150
Total: 750
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Genin Crude 50 - 50 - 100
2 Acetone 100 40 360 - 500
3 Water 75 - 75 - 150
Total: 750
STAGE-8 (For Genin)
Sr. No. Raw Material Input/Kg of Product (Kg)
1 Genin Crude 50
2 Chloroform 750
3 Methanol 330
4 Water 400
5 Caustic Potash 10
6 HCL 20
Total: 1560
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 72
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Material 20 - 30 - 50
2 Chloroform - 75 675 - 750
3 Methanol 100 30 200 - 330
4 Water 350 50 - - 400
5 Caustic Potash 10 - - - 10
6 HCL 20 - - - 20
Total: 1560
STAGE-9 (For Genin)
Sr. No. Raw Material Input/Kg of Product (Kg)
1 Material 30
2 Acetone 60
3 Methanol 60
Total: 150
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Material 5 - 25 - 30
2 Acetone - 30 30 - 60
3 Methanol - 30 30 - 60
Total: 150
STAGE-10 (For Genin)
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Material 25
2 Acetone 50
3 Methanol 200
4 Activated Carbon ICP-20 5
5 Decamax 5
Total: 285
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Genin Pure 10 - 15 - 25
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 73
2 Acetone - 20 30 - 50
3 Methanol - 20 180 - 200
4 Activated Carbon ICP-20 - - - 5 5
5 Decamax - - - 5 5
Total: 285
Figure – 8: Raw Material, Material Balance and process flow chart of Titrated Extract of
Centella
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 74
9. Valerian Officinalis Extract
Brief description of the manufacturing process:
Valerian Dry extract is extracted from the valerian roots.
List of Raw Materials:
Name of Raw Material Source Storage at the site
Valerian roots VNK BV Warehouse
MDC Paras Polymer Pvt Ltd Solvent Storage Tanks
Denatured spirit Ashoka distillary Solvent Storage Tanks
Maltodextrin Aristio chemicals Pvt Ltd Warehouse
Silicon Dioxide B. S. Mehra Sons Pvt Ltd Warehouse
MATERIAL BALANCES SHEETS FOR VALERIAN DRY EXTRACT:
STAGE-1 & STAGE-2
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Valerian Roots 650
2 Ethanol 540
3 MDC 5985
Total: 7175
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Concentrate syrup - - 45 - 45
2 Exhausted Herb - - - 650 650
3 Ethanol - 56 480 - 536
4 MDC - 85.7 5858.3 - 5931.8
Total: 7175
Valerian Roots Extraction
Valerinic acid (Valerian dry Extract) Molecular Formula: C15H22O2
Molecular Weight: 234.334
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 75
STAGE-3
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Concentrate syrup 45
2 Maltodextrin 175
3 Silicon Dioxide 11
Total: 231
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Valerian Dry Extract 26 205 - 231
2 Maltodextrin - - - - -
3 Silicon Dioxide - - - - -
Total: - - 231
Figure – 9: Raw Material, Material Balance and process flow chart of Valerian Officinalis
Extract
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 76
10. 18- Beta Glyhetitinic Acid
Brief description of the manufacturing process:
18β Glycyrrhetinic acid is a Pentacyclic triterpenoid derivative obtained from the hydrolysis of
acetyl Glycyrrhetinic acid. It is further purified by crystallization.
List of Raw Materials:
Name of Raw Material Source Storage at the site
Acetyl Glycyrrhetinic acid In House Intermediate Storage room
Methanol B. K. Sales corporation Solvent Storage Tanks
Caustic Potash Aristio chemicals Warehouse
Hydrochloric acid Chaudhary chemical industries Warehouse
Water In House Water System
Toluene Pon pure chemical India Pvt Ltd Solvent Storage Tanks
Activated Carbon Jacobi Virmani brothers Warehouse
Hyflow M/S Gem Corpochem Pvt Ltd Warehouse
MATERIAL BALANCES SHEETS FOR 18Β GLYCYRRHETINIC ACID :
STAGE-1
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Acetyl Glycyrrhetinic acid 300
2 Methanol 2400
3 Caustic Potash 120
4 Hydrochloric acid 240
5 Water 2700
Hydrolysis
18β Glycyrrhetinic acid Molecular Formula: C30H46O4
Molecular Weight: 470.68
Acetyl Glycyrrhetinic acid Molecular Formula: C32H48O5 Molecular Weight: 512
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 77
Total: 5760
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Crude 18β Glycyrrhetinic
acid
- - 240 60 300
2 Methanol - 80 2320 - 2400
3 Water 3060 - - - 3060
Total: 5760
STAGE-2 & 3
Sr. No. Raw Material Input/Kg of Product (Kg)
1 Crude 18β Glycyrrhetinic acid 240
2 Methanol 2912
3 Toluene 2476.8
4 Activated Carbon 22
5 Hyflow 9
6 Water 1800
Total: 7459.8
Sr. No. Output/Kg of product (Kg)
Total Product Liquid
effluent
Air Emission Recovery Solid
Waste
1 18β Glycyrrhetinic acid - - 195 45 240
2 Methanol - 72 2840 - 2912
3 Activated carbon +
Hyflow
- - 31 31
4 Toluene - 59.6 2417.2 - 2476.8
5 Water 1800 - - 1800
Total: 1800 131.6 5452.2 76 7459.8
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 78
Figure – 10: Raw Material, Material Balance and process flow chart of 18- Beta Glyhetitinic
Acid
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 79
11. Enoxolone
Brief description of the manufacturing process:
Enoxolone is a Pentacyclic triterpenoid derivative obtained from the hydrolysis of acetyl
Glycyrrhetinic acid. It is further purified by crystallization.
List of Raw Materials:
Name of Raw Material Source Storage at the site
Acetyl Glycyrrhetinic acid In House Intermediate Storage room
Methanol B. K. Sales corporation Solvent Storage Tanks
Caustic Potash Aristio chemicals Warehouse
Hydrochloric acid Chaudhary chemical industries Warehouse
Water In House Water System
Toluene Pon pure chemical India Pvt Ltd Solvent Storage Tanks
Activated Carbon Jacobi Virmani brothers Warehouse
Hyflow M/S Gem Corpochem Pvt Ltd Warehouse
MATERIAL BALANCES SHEETS FOR ENOXOLONE:
STAGE-1
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Acetyl Glycyrrhetinic acid 300
2 Methanol 2400
3 Caustic Potash 120
4 Hydrochloric acid 240
5 Water 2700
Hydrolysis
Enoxolone Molecular Formula: C30H46O4
Molecular Weight: 470.68
Acetyl Glycyrrhetinic acid Molecular Formula: C32H48O5 Molecular Weight: 512
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 80
Total: 5760
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Crude Enoxolone - - 240 60 300
2 Methanol - 80 2320 - 2400
3 Water 3060 - - - 3060
Total: 5760
STAGE-2 & 3
Sr. No. Raw Material Input/Kg of Product (Kg)
1 Crude Enoxolone 240
2 Methanol 2912
3 Toluene 2476.8
4 Activated Carbon 22
5 Hyflow 9
6 Water 1800
Total: 7459.8
Sr. No. Output/Kg of product (Kg)
Total Product Liquid
effluent
Air Emission Recovery Solid
Waste
1 Enoxlone - - 195 45 240
2 Methanol - 72 2840 - 2912
3 Activated carbon +
Hyflow
- - 31 31
4 Toluene - 59.6 2417.2 - 2476.8
5 Water 1800 - - 1800
Total: 1800 131.6 5452.2 76 7459.8
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 81
Figure – 11: Raw Material, Material Balance and process flow chart of Enoxolone
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 82
12. De Glycrrhizinated Liquorice ( DGL)
Brief description of the manufacturing process:
Glycyrrhizic acid is extracted from the Glycyrrhizia Glabra and is further undergo acidification &
basification to make De Glycyrrhizinated liquorice.
List of Raw Materials:
Name of Raw Material Source Storage at the site
Glycyrrhizia Glabra Herbs Warehouse
Water Water System
Ammonia solution Warehouse
Simethicone Warehouse
Sulphuric acid Warehouse
MATERIAL BALANCES SHEETS FOR DE GLYCYRRHIZINATED LIQUORICE
STAGE-1 & STAGE-2
Sr. No. Raw Material Input/Kg of Product (Kg)
1 Glycyrrhizia Glabra 2100
2 Water 21800
3 Ammonia Solution 192
4 Simethicone 9
Total: 24,101
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1. Glycyrrhizic Acid (Syrup) - - 4000 - 4000
2. Exhaust Herbs - - - 2100 2100
3. Water 601 100 17300 - 18001
4. Third party mixed solvent
Total: 24,101
STAGE- 03-04
Glycyrrhiza Glabra Extraction
De glycyrrhinated liquorice Molecular Formula: Molecular Weight:
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 83
Sr. No. Raw Material Input/Kg of Product(Kg)
1. Glycyrrhizic Acid (Syrup) 4000
2. Sulphuric acid 160
3. water 160
4. Ammonia Solution 400
Total: 4720
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 De Glycyrrhizinated
liquorice
- - 50 1200 1250
5 Sulphuric acid - - - -- -
6 Water - - - 2900 2900
7 Third party mixed
solvent
570 - - - 570
Total: 4720
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 84
Figure – 12: Raw Material, Material Balance and process flow chart of De Glycrrhizinated
Liquorice ( DGL )
13. Di Potassium Glycrrhizinate ( DPG )
Mono ammonium
Glycyrrhizzinate Chemical
modification
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 85
Brief description of the manufacturing process:
Dipotassium Glycyrrhizzinate is made from the Mono ammonium Glycyrrhizzinate.
List of Raw Materials:
Name of Raw Material Source Storage at the site
Mono ammonium
Glycyrrhizzinate
In house Warehouse
Methanol B K sales Warehouse
Potassium hydroxide Aristio chemicals Warehouse
Water In House
MATERIAL BALANCES SHEETS FOR DIPOTASSIUM GLYCYRRHIZZINATE
STAGE-1 & STAGE-2
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Mono ammonium Glycyrrhizzinate 100
2 Methanol 520
3 Water 400
3 Potassium hydroxide 15.5
4 Carbon 10.0
5 Hyflow 10.0
Total: 1055.5
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Dipotassium Glycyrrhizzinate 100 100
2 Methanol 20 500 520
3 Water 50 350 400
4 Carbon+hyflow 35.5 35.5
Total: 1055.5
Product Dipotassium Glycyrrhizzinate
Molecular Formula : C42H60K2O16
Molecular Weight: 899.123 g/mol
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 86
Figure – 13: Raw Material, Material Balance and process flow chart of Di Potassium
Glycrrhizinate ( DPG )
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 87
14. Ammonium Glycrrhizinate ( MAG )
Brief description of the manufacturing process:
Crude Glycyrrhizic Acid is produced by extraction from Glycyrrhiza Glabra herb . The extract
has been further purified by Precipitaion to give Crude Glycyrrhizic Acid and further
crystallized to give AGBP/EP.
List of Raw Materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
Glycyrrhizia Glabra Herbs Karoma Investment Pvt Ltd Warehouse
Water In House Water System
Ammonia solution Flurorides & Chemicals (India) Warehouse
Simethicone Spectrum chemiclas Warehouse
Hydrochloric acid Chaudhary chemical industries Warehouse
Acetic acid Jubilant life sciences Ltd Warehouse
Denatured Sprit Ashoka distillery Solvent Storage Tanks
Activated Carbon Virmani brothers Warehouse
Hyflow M/S Gem Corpochem Pvt Ltd Warehouse
Methanol B. K. Sales corporation Solvent Storage Tanks
MATERIAL BALANCES SHEETS FOR
STAGE-1 & 2
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Glycyrrhiza Glabra herb 3250
2
METHANOL 21840
3 Water 11700
Glabra herb
RRRRRRRRRRROOTroots
Extraction
1. AMMONIUM
GLYCYRRHIZINATE
Molecular Formula: Molecular Weight:
MOLECULAR WEIGHT
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 88
4 Sulphuric acid 178
Total: 36968
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Precipitate - 650 -- 650
2 Methanol - 100 21740 - 21840
3
Exhaust herb - 3250 3250
4
Sulphuric acid 178 - - - 178
3 WATER - 11050 11050
Total: - 36968
STAGE-3 & 4
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Precipitate 650
2 Ammonia solution 35
3 water 650
Total: 1335
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Dry material - 385 0 385
2 Water 915 - 915
3 Ammonia - 35 - 35
Total: - - 1335
STAGE-5
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Dry Material 385
2 Acetic acid 346.5
3 Methanol 105.6
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 89
Total: 837.10
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Dry Crude material 305.8 - 79.2 0 385
2 Acetic acid 346.5 - - - 346.5
3 Methanol 52.8 - 52.8 - 105.6
Total: 705.1 132 - 837.10
STAGE-6
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Dry Crude Material 79.2
2 Ethanol 858
3 Carbon 8.8
4 Hyflow 4.4
Total: 950.4
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Final material 35.2 - 44 0 79.2
2 Ethanol - 32 826 - 858
3 Carbon - - - 8.8 8.8
4 Hyflow - - - 4.4 4.4
Total: 35.2 132 770 13.2 950.4
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 90
Figure – 14: Raw Material, Material Balance and process flow chart of Ammonium
Glycrrhizinate ( MAG )
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 91
15. Acetyl Glycrrhitinic Acid (AGA)
Brief description of the manufacturing process:
Glycyrrhizic acid is extracted from the Glycyrrhizia Glabra and is further undergo Hydrolysis,
Acetylation, Toluene Methanol Treatment & methanol treatment to make Acetyl Glycyrrhetinic
Acid.
List of Raw Materials:
Name of Raw Material Source Storage at the site
Glycyrrhizia Glabra Herbs Karoma Investment Pvt Ltd Warehouse
Water In House Water System
Ammonia solution Flurorides & Chemicals (India) Warehouse
Simethicone Spectrum chemiclas Warehouse
Hydrochloric acid Chaudhary chemical industries Warehouse
Acetic acid Jubilant life sciences Ltd Warehouse
Sulphuric acid Chaudhary chemical industries Warehouse
Chloroform B. K. Sales corporation Solvent Storage Tanks
Toluene Pon pure chemical India Pvt Ltd Warehouse
Methanol B. K. Sales corporation Solvent Storage Tanks
MATERIAL BALANCES SHEETS FOR ACETYL GLYCYRRHETINIC ACID
STAGE-1 & STAGE-2
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Glycyrrhizia Glabra 2250
2 Water 21800
3 Ammonia Solution 192
Glycyrrhiza glabra roots Extraction
ACETYL GLYCYRRHETINIC ACID Molecular Formula: C32H48O5
Molecular Weight: 512.731
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 92
4 Simethicone 9.00
Total: 24,251
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1. Glycyrrhizic Acid (Syrup) - - 4000 - 4000
2. Exhaust Herbs - - - 2250 2250
3. Water - 17400 - 17400
4. Third party mixed solvent 601 601
Total: 601 21400 2250 24,251
STAGE- 03-04
Sr. No. Raw Material Input/Kg of Product(Kg)
1. Glycyrrhizic Acid (Syrup) 4000
2. Hydrochloric acid 650
3. Acetic acid 228
4. Sulphuric acid 57
5. chloroform 2595
6. Water 2600
Total: 10130
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 AGA CRUDE - - 91 109 200
2 Chloroform - 65 2530 - 2595
3 Hydrochloric acid 650 - - - 650
4 Acetic acid 228 - - - 228
5 Sulphuric acid 57 - - 57
6 Water 6400 - - - 6400
7 Third party mixed solvent - - - -
Total: 7335 65 2621 109 10130
STAGE-
05-07
Sr. No. Raw Material Input/Kg of Product(Kg)
1 AGA Crude 91
2 Toluene 683
3 Methanol 788
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 93
Total: 1562
Sr. No.
Output/Kg of product(Kg)
Total Product
Liquid
effluent
Air
Emission Recovery
Solid
Waste
1 AGA PURE - - 36.5 54.5 91
2 Toluene - 75 608 - 683
3 Methanol 106 682 788
4 Third party mixed
solvent - - - - -
Total: 181 1326.5 54.5 1562
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 94
Figure – 15: Raw Material, Material Balance and process flow chart of Acetyl Glycrrhitinic
Acid (AGA)
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 95
16. Glabradin ( 20 % )
Brief description of the manufacturing process:
Glabridin 40% is produced by extraction from roots of Glycyrrhiza glabra roots. The extract has
been further purified by column chromatography, lixivation to give glabridin20%..
List of Raw Materials:
Name of Raw Material Source Storage at the site
Glycyrrhiza Glabra roots Polygon Warehouse
MDC Paras polymers Solvent Storage Tanks
Chloroform B.K.Sales Solvent Storage Tanks
Methanol B.K.Sales Solvent Storage Tanks
Denatured Spirit Ashoka Distillary Solvent Storage Tanks
Toluene Pon Pure chemicals Ware house
HP20 RESIN Chromatography world Ware house
MATERIAL BALANCES SHEETS FOR GLABRIDIN 20%:
STAGE-1, STAGE-2& STAGE-3
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Glycyrrhiza Glabra herb 3000
2 MDC 49875
Total: 52875
Sr. No. Output/Kg of product(Kg) Total
Product Liquid Air Recovery Solid
Glycyrrhiza glabra roots
RRRRRRRRRRROOTroots
Extraction
Glabridin 20%
Molecular Formula: C20H20O4
Molecular Weight: 324.38
MOLECULAR WEIGHT
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 96
effluent Emission Waste
1 MDC dry material - - 60 60
2 MDC - 90 49725 - 49815
Exhaust Herb - 3000 3000
3
4 Third party mixed
solvent
- -
Total: 52875
STAGE-4 & STAGE-5
Sr. No. Raw Material Input/Kg of Product(Kg)
1 MDC dry material 60
2 Methanol 3600
3 Chloroform 3000
4 Water 1470
Total: 8130
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air Emission Recovery Solid
Waste
1 Chloroform dry
material
- 18 18
2 Methanol 80 3520 3600
3 Chloroform - 60 2940 - 3000
4 Water 1470 - - 1470
5 Exhaust residue - 0 42 42
6 Third party mixed
solvent
Total: 8130
STAGE-06
Sr. No. Raw Material Input/Kg of Product(Kg)
1 After toluene dry material 18
2 After column dry material 0
3 Denatured spirit 172.8
Total: 190.8
Sr. No. Output/Kg of product(Kg) Total
Product Liquid effluent Air
Emission
Recovery Solid
Waste
1 Final - - 16.5 - 16.5
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 97
material
2 Denatured
spirit
- 46.8 126 - 172.8
3 Waste
residue
1.5 1.5
4 Third party
mixed
solvent
Total: 190.8
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 98
Figure – 16 Raw Material, Material Balance and process flow chart of Glabradin ( 20 % )
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 99
17. Glabradin ( 40 % )
Brief description of the manufacturing process:
Glabridin 40% is produced by extraction from roots of Glycyrrhiza glabra roots. The extract has
been further purified by column chromatography, lixivation to give glabridin 40%..
List of Raw Materials:
Name of Raw Material Source Storage at the site
Glycyrrhiza Glabra roots Polygon Warehouse
MDC Paras polymers Solvent Storage Tanks
Chloroform B.K.Sales Solvent Storage Tanks
Methanol B.K.Sales Solvent Storage Tanks
Denatured Spirit Ashoka Distillary Solvent Storage Tanks
Toluene Pon Pure chemicals Ware house
HP20 RESIN Chromatography world Ware house
Hexane Real Chemsys Ware house
Ethyl acetate Jubliant lifesciences Ware house
MATERIAL BALANCES SHEETS FOR GLABRIDIN 40%:
STAGE-1, STAGE-2& STAGE-3
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Glycyrrhiza Glabra herb 7400
2 MDC 119700
Total: 127100
Sr. No. Output/Kg of product(Kg) Total
Glycyrrhiza glabra roots
RRRRRRRRRRROOTroots
Extraction
Glabridin 40%
Molecular Formula: C20H20O4
Molecular Weight: 324.38
MOLECULAR WEIGHT
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 100
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 MDC dry
material
- - 160 160
2 MDC - 134 119406 - 119540
Exhaust
Herb
- 7400 7400
3
4 Third party
mixed
solvent
- -
Total: 127100
STAGE-4 & STAGE-5
Sr. No. Raw Material Input/Kg of Product(Kg)
1 MDC dry material 160
2 Methanol 9250
3 Chloroform 7950
4 Water 3885
Total: 21245
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Chloroform
dry material
- 60 60
2 Methanol 60 9190 9250
3 Chloroform - 80 7870 - 7950
4 Water 3885 - - - 3885
5 Exhaust
residue
- 0 100 100
6 Third party
mixed
solvent
Total: 21245
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 101
Figure – 17: Raw Material, Material Balance and process flow chart of Glabradin ( 40 % )
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 102
18. Glabradin ( 60 % )
Brief description of the manufacturing process:
Glabridin 60% is produced by extraction from roots of Glycyrrhiza glabra roots. The extract has
been further purified by column chromatography, lixivation to give glabridin 60%..
List of Raw Materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
Glycyrrhiza Glabra roots Polygon Warehouse
MDC Paras polymers Solvent Storage Tanks
Chloroform B.K.Sales Solvent Storage Tanks
Methanol B.K.Sales Solvent Storage Tanks
Denatured Spirit Ashoka Distillary Solvent Storage Tanks
Toluene Pon Pure chemicals Ware house
HP20 RESIN Chromatography world Ware house
Hexane Real Chemsys Ware house
Ethyl acetate Jubliant lifesciences Ware house
MATERIAL BALANCES SHEETS FOR GLABRIDIN 60%:
STAGE-1, STAGE-2& STAGE-3
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Glycyrrhiza Glabra herb 8400
2 MDC 139650
Total: 148050
Sr. No. Output/Kg of product(Kg) Total
Glycyrrhiza glabra roots
RRRRRRRRRRROOTroots
Extraction
Glabridin 60%
Molecular Formula: C20H20O4
Molecular Weight: 324.38
MOLECULAR WEIGHT
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 103
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 MDC dry material - - 180 180
2 MDC - 80 139390 - 139470
Exhaust Herb - 8400 8400
3
4 Third party mixed
solvent
- -
Total: 148050
STAGE-4 & STAGE-5
Sr. No. Raw Material Input/Kg of Product(Kg)
1 MDC dry material 180
2 Methanol 10800
3 Chloroform 9000
4 Water 4410
Total: 24390
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Chloroform dry
material
- 60 60
2 Methanol - 100 10700 - 10800
3 Chloroform - 50 8950 - 9000
4 Water 4410 - - 4410
5 Exhaust residue - 0 120 120
6 Third party mixed
solvent
Total: 24390
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 104
Figure – 18: Raw Material, Material Balance and process flow chart of Glabradin ( 60 % )
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 105
19. Glabradin ( 97 % )
Brief description of the manufacturing process:
Glabridin 97% is produced by extraction from roots of Glycyrrhiza glabra roots. The extract has
been further purified by column chromatography, lixivation and final crystallization to give
glabridin 97%..
List of Raw Materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
Glycyrrhiza Glabra roots Polygon Warehouse
MDC Paras polymers Solvent Storage Tanks
Chloroform B.K.Sales Solvent Storage Tanks
Methanol B.K.Sales Solvent Storage Tanks
Denatured Spirit Ashoka Distillary Solvent Storage Tanks
Toluene Pon Pure chemicals Ware house
HP20 RESIN Chromatography world Ware house
Hexane Real Chemsys Ware house
Ethyl acetate Jubliant lifesciences Ware house
MATERIAL BALANCES SHEETS FOR GLABRIDIN 97%:
STAGE-1, STAGE-2& STAGE-3
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Glycyrrhiza Glabra herb 9000
2 MDC 146300
Total: 155300
Glycyrrhiza glabra roots
RRRRRRRRRRROOTroots
Extraction
Glabridin 97%
Molecular Formula: C20H20O4
Molecular Weight: 324.38
MOLECULAR WEIGHT
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 106
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 MDC dry material - - 180 180
2 MDC - 411 145709 - 146120
3
Exhaust Herb - 9000
4 Third party mixed solvent - -
Total: 155300
STAGE-4 & STAGE-5
Sr. No. Raw Material Input/Kg of Product(Kg)
1 MDC dry material 180
2 Methanol 10800
3 Chloroform 9000
4 Water 4410
Total: 24390
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Chloroform dry material - 60 60
2 Methanol - 80 10720 - 10800
3 Chloroform - 100 8900 - 9000
4 Water 4410 - - 4410
5 Exhaust residue - 0 120 120
6 Third party mixed solvent
Total: 24390
STAGE-6
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Chloroform dry material 60
2 Hexane 1929.6
3 Ethyl acetate 540
Total: 2529.6
Sr. No. Output/Kg of product(Kg) Total
Product Liquid Air Recovery Solid
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 107
effluent Emission Waste
1 Hexane: ethyl acetate
dry material)
- 40 - 40
2 Hexane - 68 1861.6 - 1929.6
3 Ethyl Acetate - 80 460 - 540
4 Exhaust Residue - - - 20 20
5 Third party mixed solvent - - -
Total: 2529.6
STAGE-07
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Hexane ethyl acetate dry material 40
2 Toluene 120.4
Total: 160.4
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Dry material after Hot
toluene
- 8 - 8
2 Toluene - 20.4 100 - 120.4
3 Exhaust residue 32 32
4 Third party mixed solvent
Total: 160.4
STAGE-08
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Hot toluene dry material 8
2 Denatured spirit 64
Total: 72
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Final material - - 5.3 - 5.3
2 Denatured spirit - 10 54 - 64
3 Waste residue 2.7 2.7
4 Third party mixed solvent
Total: 72
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 108
Figure – 19: Raw Material, Material Balance and process flow chart of Glabradin ( 97 % )
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 109
20. Gingerol
Brief description of the manufacturing process:
Gingerol is produced by extraction from ginger. The extract has been further purified by Phase
exchange to give Gingerol.
List of Raw Materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
Ginger Warehouse
Hexane V.S. InterchemPvt Ltd Solvent Storage Tanks
Denatured spirit Ashoka distillery Solvent Storage Tanks
MATERIAL BALANCES SHEETS FOR GINGEROL:
STAGE-1, STAGE-2
Sr. No. Raw Material Input/Kg of Product (Kg)
1 Ginger 800
2 Hexane 12800
Total: 13600
Sr. No. Output/Kg of product (Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Concentrated syrup - - 100 - 100
2 Hexane - 300 12400 - 12700
3 Exhaust herb - - - 800 800
Total: - 300 12500 800 13600
STAGE-3 & STAGE-4
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Concentrated syrup 100
2 Denatured spirit 120
Ginger Extraction
Gingerol
Molecular Formula: C17H26O4
Molecular Weight: 294.38
MOLECULAR WEIGHT
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 110
Total: 220
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Gingerol - 27 - 27
2 Denatured spirit - 50 70 - 120
3 Exhaust aqueous layer 73 - - - 73
Total: 73 50 97 - 220
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 111
Figure – 20: Raw Material, Material Balance and process flow chart of Gingerol
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 112
21. Escin
Brief description of the manufacturing process:
Escin is extracted from the Horse Chestnut Seed and is further purified through Carbon
treatment, Crystallization and Methanol Treatment.
List of Raw Materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
Horse Chestnut Seed Hansraj Traders Warehouse
Methanol B. K. Sales corporation Solvent Storage Tanks
Activated carbon ICP-20 Brilex Chemicals Solvent Storage Tanks
Decamax M/S Ecokrin Hygine Pvt Ltd Warehouse
Hydrochloric acid Chaudhary chemical industries Warehouse
Activated carbon Global Global adsorbent warehouse
MATERIAL BALANCES SHEETS FOR VALERIAN DRY EXTRACT:
STAGE-1
Sr. No. Raw Material Input/Kg of Product (Kg)
1 Horse Chestnut Seed 4000
2 Methanol 48000
Total: 52000
Sr. No. Output/Kg of product (Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Concentrate syrup - - 4000 - 4000
2 Exhausted Herb - - - 4000 4000
3 Methanol - 100 43900 - 44000
Total: - 52000
STAGE-2
Sr. No. Raw Material Input/Kg of Product(Kg)
Horse Chestnut Seed Extraction & Purification
Escin Molecular Formula: C 55 H 86 O 24
Molecular Weight: 1131.27
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 113
1 Concentrate syrup 4000
2 Methanol 1440
3 Water 2000
4 Hydrochloric acid 60
5 Activated carbon ICP-20 30
6 Decamax 30
Total: 7560
Sr. No. Output/Kg of product (Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Crude Escin - 100 - 100
2 Methanol - 76 3764 - 3840
3 Water 1560 - 2000 - 3560
4 Activated carbon +
Decamax
- - - 60 60
Total: 7560
STAGE-3
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Crude Escin 100
2 Methanol 1000
3 Global activated carbon 15
4 Decamax 3
Total: 1118
Sr. No. Output/Kg of product (Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Escin - - 80 - 80
2 Methanol - 100 900 - 1000
3 Activated carbon +
Decamax
- - - 38 38
Total: - 1118
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 114
Figure – 21: Raw Material, Material Balance and process flow chart of Escin
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 115
22. Horse Chest Nut Extract
Brief description of the manufacturing process:
Horse chestnut extract is extracted from the Horse chest nut seed and is standardized with
maltodextin.
List of Raw Materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
15. Horse chest nut seed Hans raj Warehouse
16. Methanol B K sales Solvent Storage Tanks
17. Water In House
18. Maltodextrin Aristio chemicals Warehouse
19. Silicon dioxide BS Mehra & Sons Warehouse
MATERIAL BALANCES SHEETS FOR HORSE CHEST NUT DRY EXTRACT
STAGE-1 & STAGE-2
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Horse chest nut seed 12800
2 Methanol 133120
Total: 145920
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Horse chest nut Soft mass 2300 2300
2 Exhaust herb -- 11350 11350
2 Methanol -- 150 132120 132270
Horse chest nut seed
Extraction
Horse chest nut dry extract (Active ingredients as ESCIN) Molecular Formula: C55H86O24
Molecular Weight: 1,131.27 g·mol−1
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 116
Total: 145920
STAGE-3 & STAGE-4
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Horse chest nut Soft mass 2300
2 Water 1600
3 Maltodextin 54
4 Silicon dioxide 15
Total: 3959
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Horse chest nut dry extract 1505 1505
2 Methanol 50 800 -- 850
3 Water 1600 -- 1600
4 Maltodextin -- --
5 Silicon dioxide -- -- --
Total: 3959
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 117
Figure – 22: Raw Material, Material Balance and process flow chart of Horse Chest Nut
Extract
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 118
23. Nutmeglignum
Brief description of the manufacturing process:
Nutmeglignin Extract is extracted from the Nutmeg seeds and is further purified through Column
Chromatography and Crystallization.
List of Raw Materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
20. Nut Meg seeds Namyang herb Warehouse
21. Methanol B. K. Sales corporation Solvent Storage Tanks
22. Hexane V.S. Interchem Pvt Ltd Solvent Storage Tanks
23. Ethyl acetate Jubilant life sciences Ltd Solvent Storage Tanks
24. Silica Gel(200-400) Swambe chemicals Warehouse
25. Activated Carbon Brilex Chemicals Warehouse
26. Decamex M/S Ecokrin Hygine Pvt Ltd Warehouse
MATERIAL BALANCES SHEETS FOR NUT MEG EXTRACT:
STAGE-1 & STAGE-2
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Nutmeg seeds 775
2 Methanol 8000
Total: 8775
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Concentrate Syrup - - 200 - 200
Nutmeg seeds Extraction & Purification
Nutmeglignan Molecular formula C20H24O4 Molecular weight 328.408 g/mol
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 119
2 Exhaust Herb - - - 775 775
3 Methanol - 50 7750 - 7800
Total: - 8775
STAGE-3
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Syrup 200
2 Hexane 19800
3 Ethyl acetate 500
4 Silica Gel(200-400) 600
Total: 21100
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Syrup 150 - 50 - 200
2 Hexane - 100 19700 - 19800
3 Ethyl acetate - 60 440 - 500
4 Silica Gel(200-400) - - - 600 400
Total: 21100
STAGE-4
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Syrup 50
2 Hexane 330
3 Activated Carbon 5
4 Decamax 5
Total: 390
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 NutMeglignan 15 7 28 - 50
2 Hexane - 30 300 - 330
3 Activated Carbon - - - 5 5
4 Decamex - - - 5 5
Total: 390
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 120
Figure – 23: Raw Material, Material Balance and process flow chart of Nutmeglignum
24. Ruscogenin
Butcther’s Brooms Extraction
RUSCOGENINS AS NEORUSCOGENIN
Molecular Formula: C27H40O4
Molecular Weight: 428.604 RUSCOGENIN
Molecular Formula: C27H42O4
Molecular Weight: 430.629
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 121
Brief description of the manufacturing process:
Ruscogenin is extracted from the leaves of Butcther’s Brooms and is further purified through
Phase Exchange,Column Purification & Crystallization.
List of Raw Materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
Butcther’s Brooms Roots Enco Meyve Ticaret ltd Warehouse
Methanol B.K Sales Solvent Storage Tanks
N-Butanol Radient polycan Warehouse
MDC B. K. Sales corporation Solvent Storage Tanks
Hydrochloric acid Chaudhary chemical industries Warehouse
Potassium Hydroxide Aristio chemicals Warehouse
Activated carbon Virmani brothers Warehouse
Silica gel REAL CHEMSYS Warehouse
Sodium Hydroxide Aristio chemicals Warehouse
MATERIAL BALANCES SHEETS FOR RUSCOGENIN:
STAGE-1 & STAGE-2
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Butcther’s Brooms 500
2 Methanol 6400
3 Water 1600
4 Caustic Potash 200
Total: 8700
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Concentrate Syrup - - 800 - 800
2 Exhaust Herb - - - 500 500
3 Methanol - 50 6350 - 6400
4 Water 200 800 - 1000
Total: - 8700
STAGE-3
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Concentrate Syrup 800
2 Butanol 3000
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 122
3 HCL 250
Total: 4050
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Material 950 - 100 - 1050
2 Butanol 100 50 2850 - 3000
Total: - 4050
STAGE-4
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Material 100
2 HCL 100
3 Butanol 1000
4 Caustic Potash 50
5 Water 100
Total: 1350
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Material 340 - 60 - 400
2 Butanol - 50 900 - 950
Total: 340 50 960 - 1350
STAGE-5
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Material 60
2 Methanol 300
3 Water 700
4 MDC 1300
Total: 2360
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Material 1010 - 50 - 1060
2 Methanol - - - - -
3 Water 100 1200 - 1300
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 123
4 HCL - - - - -
Total: - 2360
STAGE-6
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Material 50
2 MDC 1500
3 Methanol 50
4 Silica Gel(200-400) 150
Total: 1600
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Material - - 5 - 5
2 MDC - 100 1400 - 1500
3 Methanol - 10 40 - 50
4 Silica Gel(200-400) - - - 195 195
Total: - 1750
STAGE-6
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Material 5
2 Methanol 40
3 Activated Carbon ICP-20 .250
4 Decamax .250
5 Water 10
Total: 55.5
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Ruscogenin 2 - 3 - 5
2 Methanol - 10 30 - 40
3 Activated Carbon ICP-20 - - - .250 .250
4 Decamax - - - .250 .250
5 Water 2 8 - 10
Total: 55.5
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 124
Figure – 24: Raw Material, Material Balance and process flow chart of Ruscogenin
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 125
25. Euphorbia Prostrata Ethanolic dry Extract
Brief description of the manufacturing process:
Euphorbia Prostrata Ethanolic Liquid Extract is extracted from the Euphorbia Prostrata leaves
and is further purified through Phase Exchange.
List of Raw Materials
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
Euphorbia Prostrata leaves Panacea Biotec limited Warehouse
Denatured Spirit Ashoka distillary Solvent Storage Tanks
Hexane V.S. Interchem Pvt Ltd Solvent Storage Tanks
Ethyl Acetate Jubilant life sciences Ltd Solvent Storage Tanks
MATERIAL BALANCES SHEETS
STAGE-1 & STAGE-2
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Euphorbia Prostrata leaves 600
2 Denatured Spirit 12000
Total: 12600
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Concentrate Syrup - - 600 - 600
2 Exhaust Herb - - - 600 600
3 Denatured Spirit - 100 11300 - 11400
Total: - 100 11900 600 12600
Euphorbia Prostrata
leaves
Extraction
Euphorbia Prostrata Dry Extract
(Apigenin 7-O-glucoside)
Molecular formula: C21H20O10 Molecular weight: 432.38
Euphorbia Prostrata Dry Extract (Gallic acid)
Molecular formula: C7H6O5 Molecular weight: 170.12
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 126
STAGE-3
Sr. No. Raw Material Input/Kg of Product (Kg)
1 Concentrate syrup 600
2 Hexane 2400
3 Ethyl Acetate 10000
Total: 13000
Sr. No. Output/Kg of product (Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Euphorbia Prostrata Dry
Extract
580 - 20 - 600
2 Hexane - 50 2350 - 2400
3 Ethyl Acetate - 50 9950 - 10000
Total: - 13000
Figure – 25: Raw Material, Material Balance and process of flow chart f Euphorbia
Prostrata Ethanolic dry Extract
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 127
26. Humulus Lupulus
Brief description of the manufacturing process:
Humulus lupulus dry extractis extracted from the Humulus Lupulusand is standardized with
Lactose.
List of Raw Materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
Humulus lupulus Warehouse
Ethanol Ashoka Distillery Solvent Storage Tanks
Water In House
Lactose Alchem Solvent Storage Tanks
Silicon dioxide BS Mehra & Sons Warehouse
MATERIAL BALANCES SHEETS FOR HUMULUS LUPLUS DRY EXTRACT
STAGE-1 & STAGE-2
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Humulus Lupulus 100
2 Ethanol 1025
3 Water 1800
Total: 2925
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Humulus lupulus soft mass 25 25
2 Exhaust herb 100 100
Humulus lupulus Extraction
Humulus lupulus dry extract (Active ingredient is Rutoside) Molecular Formula: C27H30O16
Molecular Weight: 610.52 g·mol−1
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 128
3 Ethanol 50 950 1000
4 Water 200 1600 1800
Total: 2925
STAGE-3& STAGE-4
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Humulus lupulus soft mass 25
2 Methyline chloride 40
Total: 65
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Humulus lupulus dry residue 17 -- 17
2 Methyline chloride 8 40 48
Total: 65
STAGE-5& STAGE-6
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Humulus lupulus dry residue 17
2 Lactose 5
3 Silicon dioxide 0.5
Total: 22.5
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Humulus lupulus dry extract 0.5 22.0 22.5
Total:
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 129
Figure – 26: Raw Material, Material Balance and process of Humulus Lupulus
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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27. Hydro tyrasol
Brief description of the manufacturing process:
Oleuropein is extracted from the olives leaves and is further undergoing concentration, phase
exchange, Hydrolysis, column purification to make hydroxytyrosol.
List of Raw Materials:
NAME OF RAW MATERIAL STORAGE AT THE SITE
Olives leaves Warehouse
Water Water System
Methanol Solvent Storage Tanks
Methylene Chloride Solvent Storage Tanks
Hydrochloric acid Warehouse
Sodium Hydroxide Warehouse
Ethyl Acetate Warehouse
Hexane Warehouse
Silica Gel Warehouse
MATERIAL BALANCES SHEETS FOR HYDROXYTYROSOL
STAGE-1 & 2
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Olives leaves 4500
2 Water 6750
3 Methanol 48600
Total: 59,850
Sr. No. Output/Kg of product(Kg) Total
Olive leaves
Extraction & Purification
Hydroxytyrosol Molecular Formula: C8H10O3
Molecular Weight: 154.17
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Concentrated Syrup - - 6500 - 6500
2 Exhaust Herbs - - - 4500 4500
3 Third party mixed
solvent 0 100 48750 - 48850
Total:
59,850
STAGE-3 & 4
Sr. No. Raw Material Input/Kg of Product(Kg)
1. Concentrated syrup 6500
2. Methylene chloride 12970
3. Hydrochloric acid 780
4. Sodium hydroxide 500
5. Ethyl acetate 16200
6. Water 500
Total: 37,450
Sr. No. Output/Kg of product (Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Crude Hydroxytyrosol 6250 - 250 0 6500
2 Methylene chloride - 70 12900 0 12970
3 Hydrochloric acid 780 0 0 0 780
4 Sodium hydroxide 500 0 0 0 500
5 Ethyl acetate 0 50 16150 0 16200
6 Water 500 0 0 0 500
7 Third party mixed
solvent
0 0 0 0 0
Total: 37,450
STAGE-5
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Crude hydroxytyrosol 250
2 Methanol 250
3 Silica gel 1000
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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4 Hexane 9900
5 Ethyl acetate 31500
Total: 42,900
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Hydroxytyrosol 0 - 70 180 250
2 Methanol - 20 230 0 250
3 Hexane 0 75 9825 0 9900
4 Silica gel 0 0 0 1000 1000
5 Ethyl acetate 0 75 31425 0 31500
6 Third party mixed
solvent
0 0 0 0 0
Total: 42,900
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Figure – 27: Raw Material, Material Balance and process of Hydro tyrasol
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Sugar can wax(Mud)
r RRRRRRRRRRROOTroots
Extraction
Policosanol
Molecular Formula: C28H58O
Molecular Weight: 410.771 g/mol
MOLECULAR WEIGHT
28. Policosanol
Brief description of the manufacturing process:
Tobacco absolute is produced by extraction from
sugarcane mud.
List of Raw Materials:
NAME OF RAW MATERIAL STORAGE AT THE SITE
sugarcane mud Warehouse
1. MEK(Methyl Ethyl ketone) Solvent Storage Tanks
2. Decamex store
3. Methanol Solvent Storage Tanks
MATERIAL BALANCES SHEETS FOR BOSWELLIA DRY EXTRACT
STAGE-1
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Sugarcane mud 20
2 MEK 240
Total: 260
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 1st crystallized material - - 6 0 6
2 MEK - 40 200 - 240
03 Exhaust residue - - 14 14
Total: - 40 206 14 260
STAGE-2
Sr. No. Raw Material Input/Kg of Product(Kg)
1 1st crystallized material 6
2 Methanol 240
3 Decamex 3
Total: 249
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Methanol treated dry material - - 4 0 4
2 methanol - 5 235 - 240
03 Exhaust residue - - 5 5
Total: - 5 239 5 249
STAGE-3 & stage -04
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Methanol treated dry material 6
2 MEK 80
Total: 86
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Methanol treated dry material - - 2.5 0 2.5
2 methanol - 10 70 - 80
03 Exhaust residue - - 3.5 3.5
Total: - 10 72.5 3.5 86
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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APRIL’2018 136
Figure – 28: Raw Material, Material Balance and process of Policosanol
29. Tobacco Absolute
Tobacco absolute crude
r RRRRRRRRRRROOTroots Extraction
Tobacco absolute Molecular Formula: Molecular Weight:
MOLECULAR WEIGHT
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Brief description of the manufacturing process:
Tobacco absolute is produced by extraction from Tobacco absolute crude .
List of Raw Materials:
NAME OF RAW MATERIAL STORAGE AT THE SITE
Tobacco absolute crude Warehouse
4. Propylene Glycol Solvent Storage Tanks
5. Decamex store
MATERIAL BALANCES SHEETS FOR TOBACCO ABSOLUTE:
STAGE-1, STAGE-2
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Tobacco absolute crude 18
2 Decamex 6
3 Propylene Glycol 540
Total: 564
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Tobacco absolute light - - 18 0 18
2 Propylene Glycol - 30 510 - 540
03 Decamex - - 6 6
Total: - 564
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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APRIL’2018 138
Figure – 29: Raw Material, Material Balance and process of Tobacco Absolute
B. PURE HERBAL PRODUCTS PROPOSED TO BE MANUFACTURED IN THE FACTORY
1. Turmeric Extract
Brief description of the manufacturing process:
Turmeric extract is obtained after extracting ground raw Turmeric, filtered and concentrated to
desired softmass.
List of Raw Materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE
SITE
Raw Turmeric Darshan Drug House. Delhi Warehouse
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Rice Husk Mahabir Warehouse
Reverse Osmosis Water(R. O. Water) In-house Water System
Ethanol DCM Shriram, Storage Tank
MATERIAL BALANCES SHEETS FOR TURMERIC EXTRACT:
STAGE-1: Extraction
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Raw Turmeric 5
2 Water 5
3 Rice Husk 1
4 Ethanol 95
Total: 106
Sr. No. Output/Kg of product(Kg) Total
Product Liquid effluent Air Emission Recovery Solid Waste
1 Raw Turmeric - - - 5 5
2 Water - - - - 0
3 Rice Husk - - - 1.0 1
4 Ethanol - 4.0 91 - 95
Total: 0 4.0 91 6.0 101
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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APRIL’2018 140
Figure – 30: Raw Material, Material Balance and process of Turmeric Extract
2. Pomegranate Extract
Brief description of the manufacturing process:
Pomegranate extract is obtained after extracting ground Pomegranate peels, filtered,
concentrated and dried. The dried powder is milled & sifted.
List of Raw Materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
Pomegranate Peels Darshan Drug House. Warehouse
Rice Husk Mahabir Warehouse
Reverse Osmosis Water(R. O. Water) In-house Water System
Ethanol - Storage Tank
MATERIAL BALANCES SHEETS FOR POMEGRANATE EXTRACT:
STAGE-1:
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Sr. No. Raw Material Input/Kg of Product(Kg)
1 Pomegranate Peel 5
2 Water 10
3 Rice Husk 1
4 Ethanol 90
Total: 106
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Pomegranate Peel - - - 5 5
2 Water 10 - - - 10
3 Rice Husk - - - 1.0 1
4 Ethanol - 4.0 86 - 90
Total 0 4.0 86 6.0 106
Figure – 31: Raw Material, Material Balance and process of Pomegranate Extract
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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APRIL’2018 142
3. Grape Seed Extract
Brief description of the manufacturing process:
Grape Seed Phytozome is made from the Grape Seed extract & Lecimulthin dissolution & drying.
List of Raw Materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
Grape Seed extract In House Warehouse
Lecimulthin Warehouse
Denatured sprit Ashoka distillery Solvent Storage Tanks
Ethyl Acetate Jubilant life sciences Ltd Solvent Storage Tanks
MATERIAL BALANCES SHEETS FOR GRAPE SEED EXTRACT
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Grape Seed extract 25
2 Lecimulthin 50
3 Ethyl Acetate 225
4 Denatured Sprit 40
Total: 340
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Grape Seed Phytozome - - 70 5 75
2 Ethyl acetate - 75 150 - 225
3 Denatured Sprit 20 20 40
Total: - 30 305 5 340
Grape Seed Extract Dissolution & drying
Grape Seed Phytozome
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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APRIL’2018 143
Figure – 32: Raw Material, Material Balance and process of Grape Seed Extract
4. Nicotine Ditartrate Dihydrate.
Brief description of the manufacturing process:
Nicotine API which is manufactured in-house as described earlier is treated with L(+)-
Tartaric Acid & Tartaric Acid. This resulting reaction mass is filtered, and then concentrated.
The concentrated syrup is dissolved in R.O. water and crystallized in Ethanol. The crystallized
material is centrifuged and dried to form Nicotine Ditartrate Dihydrate.
Nicotine Ditartrate Dihydrate Molecular Formula: C180H26N2O12.2H2O Molecular Weight: 498.4
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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List of Raw Materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
Nicotine In-house Warehouse
Absolute Alcohol (Ethanol) Daurala Sugar Solvent Storage Tanks
Methanol B. K. Sales Solvent Storage Tanks
Reverse Osmosis Water In-house Water System
Tartaric Acid Aristo Chemicals Warehouse
MATERIAL BALANCES SHEETS FOR NICOTINE DITARTRATE DIHYDRATE:
S. No. Raw Material Input/Kg of Product(Kg)
1 Nicotine Final 7
2 Methanol 70
3 Tartaric Acid 12
4 Ethanol 60
5 Water 15
Total: 164
S. No Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Nicotine Ditartrate Dihydrate - - 18 - 18
2 Methanol 20 5 45 - 70
3 Tartaric Acid - - - - -
4 Ethanol 10 10 - - 20
5 RO Water 15 - - - 15
6 Mixed Solvent - - 41 - 41
Total: 45 15 104 164
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Figure – 33: Raw Material, Material Balance and process of Nicotine Ditartrate Dihydrate.
5. Nicotine Polacrilex
Brief description of the manufacturing process:
Nicotine API which is manufactured in-house as described in the earlier section is treated
with Amberlite IRP-64 Resin. This nicotine-resin complex is further washed with acetone and
treated with ethanol & glycerol to form Nicotine Polacrilex, also known as Nicotine Resinate.
Nicotine Polacrilex/Resinate Molecular Formula: C10H14N2 x (C10H10C4H6O2)Y
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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List of Raw Materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
Nicotine In-house Warehouse
Acetone Pon Pure Chemical Solvent Storage Tanks
Amberlite IRP-64 Resin Virmani Brothers Warehouse
Absolute Alcohol (Ethanol) Daurala Sugar Solvent Storage Tanks
Glycerol Real Chemsys Warehouse
Reverse Osmosis Water In-house Water System
MATERIAL BALANCES SHEETS FOR NICOTINE POLACRILEX
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Nicotine Final 10
2 Acetone 600
3 Amberlite Resin 50
4 Ethanol 500
5 Water 2000
6 Glycerol 30
Total: 3190
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Nicotine Polacrilex - - 60 - 60
2 Acetone 15 10 575 - 600
3 Amberlite Resin - - - - -
4 Ethanol 10 10 480 - 500
5 Glycerol - - - 20 20
6 RO Water 1950 50 - - 2000
7 Mixed solvent - - 10 - 10
Total 1975 70 1125 20 3190
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Figure – 34: Raw Material, Material Balance and process of Nicotine Polacrilex
6. Pygeum Extract
Brief description of the manufacturing process:
Pygeum Extract is manufactured by extraction of Pygeum bark using Methylene Chloride.
List of Raw Materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
1. Pygeum Bark World Botanical Warehouse
2. Methylene chloride B. K. Sales Solvent Storage Tanks
MATERIAL BALANCES SHEETS FOR PYGEUM EXTRACT
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Pygeum Africana Bark 2,000
2 Methylene Di Chloride 20000
Total: 22000
Sr. No. Output/Kg of product(Kg) Total
Product Liquid effluent Air
Emission
Recovery Solid
Waste
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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1 Pygeum Extract - - 10 - 10
2 Pygeum Africana Bark - - - 1990 1990
3 Methylene Di Chloride 40 50 19910 - 20000
Total: 40 50 19920 1990 22000
Figure – 35: Raw Material, Material Balance and process of Pygeum Extract
7. Milk Thistle Extract
IUPAC Name:
(2S,3R)-3,5,7-trihydroxy-2-[(2S,3S)-3-(4-
hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-
2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-
dihydrochromen-4-one.
Molecular Formula: C25H22O10
CAS Registry Number: 22888-70-6
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Briefdescription of the manufacturing process:
Silymarin is extracted from the Cardus marianum seeds and is further purified through Column
Phase exchange, Concentration, filtration and thermo vacuum drying.
List of Raw Materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
Cardus marianumSeeds
Herbar SP.Z.O, Poland.
PharmekoLettland, Madona
Latvia
Warehouse
Rice Husk Mahabir, Sai Traders Warehouse
Reverse Osmosis Water(R. O.
Water)
In-house Water System
Acetone B K Sales, Real Chemsys, Ghaziabad Storage Tank
Hexane Real Chemsys, Ghaziabad Storage Tank
1. Ethanol DCM Shriram, Storage Tank
MATERIAL BALANCES SHEETS FOR SILYMARIN/MILK THISTLE DRY EXTRACT:
STAGE-1: Extraction & Purification
Sr. No. Raw Material Input/Kg of Product(Kg)
1. Cardus marianum seeds 20
2. RO Water 8
3. Rice Husk 5
4. Acetone 300
5. Hexane 10
6. Ethanol 20
Total: 363
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Cardus marianum seeds - - - 20 20
2 RO Water - - 8 - 8
3 Rice Husk 5 5
4 Acetone 45 255 300
5 Hexane 1 9 10
6 Ethanol 2 18 20
Total: 363
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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APRIL’2018 150
Figure – 36: Raw Material, Material Balance and process of Milk Thistle Extract
8. Red Clover Extract
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Brief description of the manufacturing process:
Red clover is extracted from Red clover herb and purified via solvent washing,
List of Raw Materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
Red Clover Herb Darshan Drug House Warehouse
Rice Husk Mahabir Warehouse
Reverse Osmosis Water(R. O.
Water)
In-house Water System
Methanol B K Sales Storage Tank
Hydrochloric Acid Ganpati Chemicals, Karni Chemicals Warehouse
Ammonia Solution Ganpati Chemicals, Karni Chemicals Warehouse
Calcium Chloride Adhunik Warehouse
MATERIAL BALANCES SHEETS FOR RED CLOVER EXTRACT
STAGE: Extraction
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Red Clover Herb 20
2 Rice Husk 5
3 Ethanol 140
4 Water 60
Total: 225
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Red Clover Herb - - - 20 20
2 Rice Husk - - - 5 5
3 Ethanol - 4 136 - 136
4 Water 15 - 45 - 60
Total: 15 4 181 25 225
STAGE: Purification up to Drying
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Hexane 10
Total: 10
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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1 Hexane - 1 9.0 - 10
Total: 0 1 9.0 - 10
Figure – 37: Raw Material, Material Balance and process of Red clover
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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9. Nicotine Di Hydrate Di Tartrate
Brief description of the manufacturing process:
Nicotine API which is manufactured in-house as described earlier is treated with L(+)- Tartaric
Acid & Tartaric Acid. This resulting reaction mass is filtered, and then concentrated. The
concentrated syrup is dissolved in R.O. water and crystallized in Ethanol. The crystallized
material is centrifuged and dried to form Nicotine Ditartrate Dihydrate.
List of Raw Materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
Nicotine In-house Warehouse
Absolute Alcohol (Ethanol) Daurala Sugar Solvent Storage Tanks
Methanol B. K. Sales Solvent Storage Tanks
Reverse Osmosis Water In-house Water System
Tartaric Acid Aristo Chemicals Warehouse
MATERIAL BALANCES SHEETS FOR NICOTINE DITARTRATE DIHYDRATE:
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Nicotine Final 7
2 Methanol 70
3 Tartaric Acid 12
4 Ethanol 60
5 Water 15
Total: 164
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Nicotine Ditartrate Dihydrate - - 18 - 18
2 Methanol 20 5 45 - 70
3 Tartaric Acid - - - - -
Nicotine Ditartrate Dihydrate Molecular Formula: C180H26N2O12.2H2O Molecular Weight: 498.4
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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4 Ethanol 10 10 - - 20
5 RO Water 15 - - - 15
6 Mixed Solvent - - 41 - 41
Total: 45 15 104 164
Figure – 38: Raw Material, Material Balance and process of Nicotine Di Hydrate Di Tartrate
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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C. SEMI SYNTHETIC PRODUCTS PROPOSED TO BE MANUFACTURED IN THE FACTORY
1. Hyoscine Butyl Bromide
Brief description of the manufacturing process
Duboisia leaves are extracted with mixture of Chloroform and Methanol to produce Hyoscine
Syrup which is reacted with Hydrobromic Acid to produce Hyoscine Hydrobromide. Hyoscine
DuboisiaLeaves
Hyoscine Butylbromide Molecular Formula: C21H30BrNO4 Molecular Weight: 440.4
n-Butylbromide
reaction
Hyoscine Molecular Formula: C17H21NO4
Molecular Weight: 303.35
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Hydrobromide is basified to form pure Hyoscine syrup, which is treated with n-butylbromide to
make Hyoscine butylbromide. It is further purified by crystallization and washing to produce
Hyoscine Butylbromide API.
List of Raw Materials
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
DuboisiaLeaves Twin Multiflora Warehouse
Acetonitrile Bharat Jyoti Solvent Storage Tanks
Activated Carbon Brilex Chemicals Warehouse
Ammonia Solution Karni Chemicals, Ganpati Warehouse
n-Butylbromide Neogen Chemicals Limited Warehouse
Hydrobromic Acid Neogen Chemicals Limited Warehouse
HyfloSupercel (Filter aid) Gem Corporation Warehouse
Methanol B. K. Sales Solvent Storage Tanks
Methylene Chloride B. K. Sales Solvent Storage Tanks
Purified Water in bulk In-house Water System
Reverse Osmosis Water
(R. O. Water)
In-house Water System
MATERIAL BALANCE SHEETS FOR HYOSCINE BUTYLBROMIDE:
Stage-1: Extraction
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Duboisia Leaves 40.00 kg
2 Rice Husk 10.00 kg
3 Methanol 54 liters
4 Chloroform 540 liters
5 Soda ash 0.80 kg
6 R.O. water 2 liters
Total:
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Duboisia Leaves - - - 45 45.0
2 Rice Husk - - - 12.0 12.0
3 Methanol - 2.0 58.0 - 60.0
4 Chloroform - 30.0 570.0 - 600.0
5 Soda ash - - - 0.9 0.9
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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6 R.O. water 2.0 - - - 2.0
Total: 2.0 32.0 628.0 57.9 719.9
STAGE-2: HHBr crude
Sr. No. Raw Material Input/Kg of Product(Kg)
1 R.O. water 75 liters
2 Hydrochloric Acid 1.5 liters
3 Methylene Chloride 150 liters
4 Ammonia Solution 1.1 liters
5 Hydrobromic Acid 0.500 liters
6 Methanol 20 liters
Total: 248.1
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 R.O. water 75.0 - - - 75.0
2 Hydrochloric Acid 1.5 - - - 1.5
3 Methylene Chloride - 8.0 142.0 - 150.0
4 Ammonia Solution 1.1 - - - 1.1
5 Hydrobromic Acid 1.1 - - - -
6 Methanol - 2.0 18.0 - 20.0
Total: 77.6 10.0 160.0 0 248.1
Stage-3: Hyoscine Syrup Formation
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Hyoscine Hydrobromide crude 1.4
2 Liquid Ammonia 0.6
3 MDC 5.0
4 Water 4.0
Total: 11.0
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Hyoscine Hydrobromide crude - - - - 1.4
2 MDC - 0.5 4.5 - 5.0
4 Water 4.0 - - - 4.0
5 Liquid Ammonia 0.6 - - - 0.6
Total: 4.6 0.5 4.5 0 11.0
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Stage-4: HBBr crude Formation
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Hyoscine Syrup 1.1
2 Acetonitrile 1.1
3 Butyl bromide 1.1
4 Methanol 4.0
Total: 7.3
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Hyoscine Syrup - - - - 1.1
2 Acetonitrile - - - - 0
3 Butyl bromide - - - - 0
4 Methanol - - - - 0
5 Third party mixed solvent 6.2 - - - 6.2
Total: 6.2 0 0 0 7.3
Stage-5: Final HBBr API
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Hyoscine butyl bromide(crude) 1.1
2 Methanol 8.0
3 Carbon 0.1
Total: 9.2
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Hyoscine Butyl bromide(API) - - - - -
2 Methanol - 0.5 7.5 - 8.0
3 Carbon - - - 0.1 0.1
Total: 0 0.5 7.5 0.1 8.1
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Figure – 39: Raw Material, Material Balance and process of Hyoscine Butyl Bromide
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Hyoscine Molecular Formula: C17H21NO4
Molecular Weight: 303.35 Hyoscine Molecular Formula: C17H21NO4
Molecular Weight: 303.35
Hyoscine Hydrobromide Molecular Formula: C17H21NO4. HBr Molecular Weight: 384.4 Hyoscine Hydrobromide Molecular Formula: C17H21NO4. HBr Molecular Weight: 384.4
ExtractionE
xtraction
Hydrobromic Acid
ReactionHydrobrom
ic Acid Reaction
2. Hyoscine Hydrobromide
Brief description of the manufacturing process
Hyoscine Hydrobromide is basified to form pure Hyoscine syrup, which is treated with n-
butylbromide to make Hyoscine butylbromide. It is further purified by crystallization and
washing to produce Hyoscine Butylbromide API.
List of Raw Materials
Name of Raw Material Source Storage at the site
1. DuboisiaLeaves Twin Multiflora Warehouse
2. Acetonitrile Bharat Jyoti Solvent Storage Tanks
3. Activated Carbon Brilex Chemicals Warehouse
4. Ammonia Solution Karni Chemicals, Ganpati Warehouse
5. n-Butylbromide Neogen Chemicals Limited Warehouse
6. Hydrobromic Acid Neogen Chemicals Limited Warehouse
7. HyfloSupercel (Filter aid) Gem Corporation Warehouse
8. Methanol B. K. Sales Solvent Storage Tanks
9. Methylene Chloride B. K. Sales Solvent Storage Tanks
10. Purified Water in bulk In-house Water System
11. Reverse Osmosis Water
(R. O. Water)
In-house Water System
Stage-1: Hyoscine Syrup Formation
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Sr. No. Raw Material Input/Kg of Product(Kg)
1 Hyoscine Hydrobromide crude 1.4
2 Liquid Ammonia 0.6
3 MDC 5.0
4 Water 4.0
Total: 11.0
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Hyoscine Hydrobromide crude - - - - 1.4
2 MDC - 0.5 4.5 - 5.0
4 Water 4.0 - - - 4.0
5 Liquid Ammonia 0.6 - - - 0.6
Total: 4.6 0.5 4.5 0 11.0
Stage-2: HBBr crude Formation
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Hyoscine Syrup 1.1
2 Acetonitrile 1.1
3 Butyl bromide 1.1
4 Methanol 4.0
Total: 7.3
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Hyoscine Syrup - - - - 1.1
2 Acetonitrile - - - - 0
3 Butyl bromide - - - - 0
4 Methanol - - - - 0
5 Third party mixed solvent 6.2 - - - 6.2
Total: 6.2 0 0 0 7.3
Stage-3: Final HBBr API
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Hyoscine butyl bromide(crude) 1.1
2 Methanol 8.0
3 Carbon 0.1
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Total: 9.2
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Hyoscine Butyl bromide(API) - - - - -
2 Methanol - 0.5 7.5 - 8.0
3 Carbon - - - 0.1 0.1
Total: 0 0.5 7.5 0.1 8.1
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Figure – 40.: Raw Material, Material Balance and process of Hyoscine Hydrobromide
3. Hyoscamine Sulfate
Hyoscyamine Hyoscyaminesulphate
List of Raw Materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
Hyoscamine Crude In-house Warehouse
Sulfuric Acid Choudhary Chemicals Warehouse
Acetone V.S. Interchem Private Limited Solvent Storage Tanks
Distilled Water In-house Water System
Sulphuric Acid Super Acid Warehouse
MATERIAL BALANCE FOR HYOSCAMINE SULPHATE:
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Hyoscamine Crude 6
2 Sulfuric acid 1.3
3 Water 11.7
3 Acetone 142
Total: 161
Sr. No. Output/MT of product Total
Product Liquid
effluent
Air
Emission
Recovery Solid Waste
1 Hyoscamine
Sulfate
1.2 0.2 6 - 7.4
2 Sulfuric acid 0.3 - - - 0.3
3 Water 11.3 - - - 11.3
4 Acetone 20 2.0 120 - 142
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Total: 34.8 0.2 126 - 161
Figure – 41.: Raw Material, Material Balance and process of Hyoscamine Sulfate
4. Atropine Sulfate
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Brief description of the manufacturing process:
Hyoscyamine is extracted from Duboisia Leaves. It is further purified through phase exchange,
concentration, crystallization, column chromatography, concentration, re-crystallization,
filtration & vacuum drying. The pure Hyoscyamine is racemized into Atropine and further
purified, crystallized & dried. The dry atropine is reacted with Sulfuric acid, purified crystallized,
filtered & dry to get Atropine Sulfate.
List of Raw Materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE
SITE
Duboisia Leaves Queensland Botanicals Pty Ltd., Warehouse
Rice Husk Sai Traders,Mahavir Trading Company, ARS
Paddy Husk (P) Ltd Warehouse
Methanol B. K. Sales corporation, Warehouse
Chloroform Ganpati Chemical Co. Storage Tank
Soda ash M/S Syndic India, Warehouse
Reverse Osmosis Water (R. O.
Water)
In House Water System
Hydrochloric Acid
Ganpati chemicals, A.G Gasochem Pvt.
Ltd, Ganpati chemicals Company, Sunil Kumar &
Brother, Shri karni Chemicals,
Warehouse
Methylene Chloride V.S. InterchemPvt Ltd, B. K. Sales corporation,
Paras Polymer Pvt. Ltd. Storage Tank
Ammonia Solution Ganpati chemicals Corporation, Shri kArni
Chemicals Warehouse
Toluene V.S. InterchemPvt Ltd, B. K. Sales corporation,
Paras Polymer Pvt. Ltd. Warehouse
Hexane V.S. InterchemPvt Ltd, B. K. Sales corporation,
Paras Polymer Pvt. Ltd. Warehouse
Alumina Oxide Dessica Chemicals, Real Chemsys. Warehouse
Acetone V.S. InterchemPvt Ltd, B. K. Sales corporation,
Paras Polymer Pvt. Ltd. Warehouse
Hiflo Gem Corporation Warehouse
Sulfuric Acid Karni Chemicals, Ganpati Chemicals Warehouse
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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MATERIAL BALANCES SHEETS FOR HYOSCYAMINE:
STAGE-1: Extraction
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Duboisia Leaves 2500 kg
2 Rice Husk 625 kg
3 Methanol 3000 L
4 Chloroform 30000 L
5 Soda ash 45 kg
6 R.O. water 500L
Total: 36670
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Duboisia Leaves - - - 2500 2500
2 Rice Husk - - - 625 625
3 Methanol - 50 2950 - 3000
4 Chloroform - 500 29500 - 30000
5 Soda ash 20 - - 25 45
6 R.O. water 500 - - - 500
Total: 520 550 32450 3150 36670
STAGE-2 Semi Purification
Sr. No. Raw Material Input/Kg of Product(Kg)
1 R.O. water 3000 liters
2 Hydrochloric Acid 75 liters
3 Methylene Chloride 2000 liters
4 Ammonia Solution 150 liters
5 Methanol 800 liters
6 Toluene 120 liters
7 Hexane 2 liters
Total: 6147
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 R.O. water 3000 - - - 3000
2 Hydrochloric Acid 75 - - - 75
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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3 Methylene Chloride - 100 1900 - 2000
4 Ammonia Solution 150 - - - 150
5 Methanol - 40 760 - 800
6 Toluene - 3 117 - 120
7 Hexane - 0.2 1.8 - 2.0
Total: 3225 143.2 2778.8 0 6147
STAGE-3: Final Purification
Sr. No. Raw Material Input/Kg of Product(Kg)
Hyoscyamine 1.0
Methylene Chloride 100 liters
1. Alumina 30 kg
Toluene 30liters
Acetone 30 liters
Hiflo Supercell 0.4 kg
Triethyl amine 1.2 liters
Chloroform 3.0 liters
R O Water 3.0 liters
Activated Carbon 0.1
Total: 198.6
Sr. No. Output/Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Hyoscyamine - 5 95 - 100
2 Methylene Chloride - - - 30 30
3 Alumina - 1 29 - 30
4 Toluene - 1 14 - 15
5 Acetone 1.5 28.5 30
6 Hiflo Supercell 0.4 0.4
7 Triethyl amine - 0.2 1.0 1.2
8 Chloroform 0.2 2.8 3.0
9 R O Water 3.0 3.0
10 Activated Carbon 0.1 0.1
Total: 3 8.9 170.3 30.5 198.6
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Figure – 42.: Raw Material, Material Balance and process of Atropine Sulfate
5. Cimetropium Bromide
Hyoscine Cimetropium Bromide
List of Raw Materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
Hyoscine Syrup In-house Warehouse
Cyclopropyle methyl bromide Unisynaxis Laboratories
Private Limited,
Warehouse
Acetonitrile V.S. Interchem Private
Limited
Solvent Storage Tanks
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Methylene Di Chloride V.S. Interchem Private
Limited
Solvent Storage Tanks
Ethyl Alcohol DCM, Daurala Solvent Storage Tanks
Distilled Water In-house Water System
Methanol B. K. Sales Solvent Storage Tanks
MATERIALS BALANCE FOR CIMETROPIUM BROMIDE:
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Hyoscine syrup 021
2 Cyclopropyle methyl bromide 046
3 MDC 452
4 Acetonitrile 110
5 Methyl alcohol 115
6 Ethyl alcohol 032
776
Total:
Sr. No. Output/MT of product Remark
Product Liquid effluent Air
Emission
Recovery Solid
Waste
1 Cimetropium Methyl
Bromide
15 - 16 - 31
2 MDC 02+6 20 430 - 458
3 Acetonitrile 5+10 5 100 - 120
4 Ethanol - 5 - - 5
5 Third party mixed solvent - - - - 162
Total: 38+162 30 546 776
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Figure – 43: Raw Material, Material Balance and process of Cimetropium Bromide
6. Methscopolamine Bromide
Hyoscine Hydrobromide Methscopolamine Bromide
(Natural origin) Quarternary salt formation on nitrogen. Minor change
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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List of raw materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
Hyoscine Hydrobromide Crude In-house Warehouse
Methyl Bromide Unisynaxis Laboratories Private
Limited,
Warehouse
Acetonitrile V.S. Interchem Private Limited Solvent Storage Tanks
Ethanol DCM, Daurala Warehouse
Methylene Chloride B. K. Sales Solvent Storage Tanks
Distilled Water In-house Water System
MATERIAL BALANCE FORMETHESCOPLAMINE BROMIDE
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Hyosine Hydro Bromide (crude) 12
2 Methyl Bromide 30
3 Acetonitrile (ACN) 23.6
4 Ethanol 65.1
5 Water 107.5
6 MDC 399
Total: 637.2
Sr. No. Output/ Kg of product(Kg) Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Methescoplamine Bromide 3.7 - 7.2 - 10.9
2 Ethanol - 5 - - 5
3 Water 107.5+2.5 - - - 110
4 MDC - 19 380 - 399
5 Third party mixed solvent - - - - 112.3
Total: 113.7 14 387.2 - 637.2
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Figure – 44: Raw Material, Material Balance and process of Methscopolamine Bromide
7. Homa Tropine Methyl Bromide
Homatropine HomatropineMethylbromide
(Natural origin) Quarternary salt formation on nitrogen. Minor change
List of Raw Materials
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
Mandelic Acid Warehouse
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Acetyl Chloride Warehouse
Acetone V.S. Interchem Private Limited Solvent Storage Tanks
Thionyl Chloride Warehouse
Tropine In House Warehouse
Distilled Water In-house Water System
Ethanol DCM, Daurala Solvent Storage Tanks
Ethyl Alcohol B. K. Sales Solvent Storage Tanks
Reverse Osmosis Water In-house Water System
MATERIALS BALANCE FOR HOMATROPINE METHYL BROMIDE
Sr.
No.
Raw Material Input/Kg of Product(Kg)
1 Mandelic acid 5
2 Acetyl chloride 7.7
3 Thionyl chloride 11.5
4 Tropine 4.2
5 MDC 320
6 Water 56
7 Acetone 88.6
8 Methyl Bromide 26
9 Ethanol 23.7
- - -
Total: 542.7
Sr.
No.
Output/MT of product Remark
Product Liquid effluent Air
Emission
Recovery Solid
Waste
1 Homatropine Methyl
Bromide (Pure)
3.2+1.8 - 6 - 11
2 MDC - 15 300 - 315
3 Water 56+15 - - - 71
4 Acetone - 3.6 80 - 83.6
5 Third party mixed solvent 62.1 - 62.1
Total: 138.1 18.6 386 - 542.7
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Figure – 45: Raw Material, Material Balance and process of Homa Tropine Methyl Bromide
8. Reserpine
Brief description of the manufacturing process:
Reserpine is extracted through Rauwolfia Vomitoria roots through Methanolic Extraction.
The extract is further purified via Phase Exchange, Crystallization and Column
Chromatography to produce Reserpine API.
Rauwolfia
Vomitoria roots
Extraction &
Purification
Reserpine Molecular Formula: C33H40N2O9
Molecular Weight: 608.68
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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List of Raw Materials:
NAME OF RAW MATERIAL SOURCE STORAGE AT THE SITE
Rauwolfia Vomitoria World Botanical Warehouse
Absolute Alcohol (Ethanol) Daurala Sugar Solvent Storage Tanks
Alumina oxide neutral Real Chemsys Warehouse
Ammonia Solution Fluorides Warehouse
n-Butanol Radiant Warehouse
Methanol B. K. Sales Solvent Storage Tanks
Methylene chloride B. K. Sales Solvent Storage Tanks
Reverse Osmosis Water
(R. O. Water)
In-house Water System
Silica Gel (60-120 Mesh) Real Chemsys Warehouse
Toluene V. S. Interchem Private Limited Solvent Storage Tanks
MATERIAL BALANCE SHEETS FOR RESERPINE:
STAGE-01
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Rauwolfia powder 4000
2 Husk 400
3 Methanol 31680
4 Toluene 6069
Total 42149
Sr. No. Output/MT of product Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Syrup - - 350 - 350
2 Exhausted powder with husk - - - 4400 4400
3 Methanol 1580 1600 28500 - 31680
4 Toluene 309 260 5150 - 5719
Total 1889 1860 34000 4400 42149
STAGE-02
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Syrup 350
2 Ethanol 572
Total 922
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Sr. No. Output/MT of product Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Reserpine(crude) - - 35 - 31
2 Ethanol 50 52 470 - 572
3 Toluene 39 280 - 319
Total 50 91 781 - 922
STAGE-03
Sr. No. Raw Material Input/Kg of Product(Kg)
1 Reserpine(crude) 35
2 MDC 2190
3 Ethanol 280
4 Butanol 195
5 Water 210
Total 2910
Sr. No. Output/MT of product Total
Product Liquid
effluent
Air
Emission
Recovery Solid
Waste
1 Reserpine 8 - 27 - 35
2 MDC - 220 1970 - 2190
3 Ethanol 60 20 200 - 280
4 Butanol 60 15 120 - 195
5 Water 210 - - - 210
Total 338 255 2317 - 2910
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Figure – 46: Raw Material, Material Balance and process of Reserpine
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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3.9 QUANTITY OF WASTES TO BE GENERATED (LIQUID AND SOLID) AND SCHEME FOR
THEIR MANAGEMENT/ DISPOSAL.
3.9.1 SOLID
Solid Waste Generation
Hazardous waste generation
S
No.
Hazardous
waste
description
Category
as per
HWMR
Rules
Existing
Quantity
per annum
proposed
Quantity
per annum
Total
per
annum
Unit Method of
Disposal
1 ETP Sludge 34.3 2400 600 3000 Kg
It will be sent to
GEPIL site at
Faridabad for
treatment and
disposal
2 Used Oils and
Spent Oil
5.1 & 5.2 1000 - 1000 Lit
3 Process residue
and waste
process oil
28.1 20000 10000 30000 Kg
4 Off
Specification
product
28.3 100 100 200 Kg
5 Expiry Drugs/
Medicines
28.4 100 100 200 Kg
6 Spent Solvent 28.6 12000 6000 18000 LTR
7 Spent Carbon 28.3 450 250 700 Kg
8 Empty Barrels
and Containers
33.1 300 150 450 Nos
Particulars Existing Proposed
Total
Treatment/ disposal
Herbal extract left over
(TPA)
1650 150 1800 100% used in Husk fired boiler
Municipal Solid Waste
(Kg/ day)
99 17 116 It is being sent to Sent to Municipal corporation,
Panipat. For proposed capacity the same practice
will be follow.
Husk Ash 500 -- 500
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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3.9.2 WATER REQUIREMENT AND WASTE WATER GENERATION
The present water requirements for the existing facility are 74 KLD. As there is an increase in
the production capacity post this expansion the total water requirement as detailed earlier
also would increase to 100 KLD after the installation of the ZLD system.
Existing Water consumption & Waste water generation details
Description Water Consumption
KLD
Waste Water
Generation
(KLD)
Effluent
Treatment &
disposal facility
Domestic use
Domestic 5 2 To STP (10KLD)
Industrial Use
a) Process 13 11 To ETP (25KLD)
b) Cooling tower 24 4
To ETP(25KLD)
c) Boiler/RO 25 3
d) Floor washing and
equipment washing
7 7
Fresh water
consumption
74 27
* Source: Existing bore well.
After expansion with change in water mix one-time water requirement is 120 KLD. Daily fresh
water requirement is 100 KLD and 20 KLD water will be recycled.
Proposed Water Demand and Waste Water generation
The water demand for proposed expansion and change in product mix is given in the flow chart
below:
Description Water Consumption
KLD
Waste Water
Generation (KLD)
Effluent
Treatment
& disposal
facility
Domestic use
Domestic 9 6 To STP (Cap.15KLD)
Industrial Use
Process 18 16 To ETP (Cap.35KLD)
followed by ZLD
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Cooling tower 43 (15 KL Fresh
make up water + 28
KL treated water)
5 To ETP followed by RO
for further use in process
Boiler 30 4
RO reject 8 4 For flushing after
treatment
4 To ETP followed by RO
for further use in cooling
tower.
Horticulture / Green Area
Development
10 --
Fresh Water Demand 80
Recycled water 28
Total water consumption 108
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Waste Water16 KL
2 KL
Process
Loss
RO Reject
The one time water demand will be 108 KLD. Daily fresh water demand - 80 KLD and the recycled water - 28 KLD
R.O. / DM Plant 80 KL
Boiler 51 KL (30 KL Fresh make up water + 21 KL Condensate Recovery
water)
Cooling Tower 43 KL (15 KL Fresh make up water + 28
KL treated water)
Domestic 9 KL
70 % Condensate
Recovery (21 KL)
Process 18 KL
R.O. Reject 8 KL
Reused in Horticulture (Green Area 6700 m2 area)
10 KL To be reused for
CT 23 KL
MEE 06 KL
R.O. Plant 29 KL
R.O. Permeate23K
L
5KL To be
reused for CT
Blow Down 4 KL
Blow Down 5 KL
Evaporation loss 38 KL
ETP 16+4+4+5= 29 KL
Floor Washing 4
KL
Consumption 3 KL
STP 4 + 6 = 10 KL
Dry Sludge 10 Kg
For Flushing
4 KL
10.0 Kg Solid
Waste – Use as
Manure
Sent GEPIL-Faridabad
for Disposal
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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A. ETP
The discharge design of the effluent is based on a capacity of 35 KLPD.
Table : Influent characteristics
S. No. Parameters Value Unit
1 COD 5000- 8000 mg/l
2 BOD 300- 350 mg/l
3 TSS 125- 180 mg/l
4 pH 6.0- 9.0
5 OIL & GREASE 5- 10 mg/l
Table: Treated Effluent Characteristics
S. No. Parameters Value Unit
1 COD <250 mg/l
2 BOD <100 mg/l
3 TSS <100 mg/l
4 pH 5.5 to 9.0
The detailed design of the ETP is as under
ETP DESIGN
The details of ETP operations
1. Equalization Tank (ET)
Receive the various liquid effluents generated by the process into ET via bar screen
chamber and oil & grease trap.
Start the aerator in effluent continuously.
Pump the collected and equalized effluent to the next stage of Flocculation System No-
1. (FSN-1) in regulated fashion.
Draw a sample of effluent each day.
Ensure that water level indication mark above the fourth level from the top is always
visible. Adjust the outflow from tank accordingly.
When level goes below fourth level from top, stop pumping. Resume when the level
touches the fourth level mark from top.
Allow boiler blow down water in Equalization tank to keep the water warm.
2 Flocculation Systems No. 1-1 (FSN-1):-
Prepare chemical solutions in dosing tanks.
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Start the dosing of coagulant & flocculants in flocculation system no. 1.
Allow the effluent freely flow from the primary settling tank.
Add 50-200 PPM Microflock-90 solution to FSN-1 (1.0 liter Micro flock added to 200
liter water) continuously as a trickle over 12 Hrs. Maintain continuous additions round
the clock.
Add 10-30 PPM ferric chloride to FSN-1 (0.5 Kg ferric chloride in 200 liter water)
continuously as a trickle over 12 Hrs. Maintain continuous additions round the clock.
Let the tank over flow by gravity to the next stage of Primary Settling Tank (PST).
Start the sludge pump of primary settling tank.
Store the primary treated effluent in intermediate storage tank.
Start to pump the effluent in USAB for biological treatment.
3 Up-Flow Anaerobic Sludge Blanket (UASB)
Allow the effluent in USAB for biological treatment.
Prepare nutrient solution in dosing drum & start the dosing of DAP in intermediate
storage tank.
Maintain D.O. level less than 0.2 mg/l, alkalinity 1000-5000mg/l &COD:N:P::250 :5 : 1 .
Feed effluent from UASB to first stage aeration tank.
Monitor the temperature in the outflow effluent. It should not exceed 37 0C. Preferably
33-370C.
Collect sample from UASB outlets daily.
4. Filter Press No-1 (FP-1) 5. Aeration Tank No-1 (AT-1)
Receive effluent on a continuous basis.
Run the air blower to continuously purge air in the effluent.
Dose Micro flock-90 (1 liter micro flock-90 in 100 liter water) at a trickle over 12 hours
at the AT-1 over flow line Maintain continuous additions round the clock if required.
Draw a sample of slurry periodically.
Add 500 gmsgud in the tank as & when required to maintain MLSS
Modify sludge wasting frequency so as to have mixed liquor suspended solids (MLSS)
at 2500 to 5000 PPM.
6. Clarifier No-1 (CF-1)
Receive the effluent in the drum located in the center of CF-1.
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Run the scrapper on a continuous basis. The sludge is pumped for recirculation from
CF-1 to AT-1 continuously.
Allow the clarified effluent to overflow into outlet launder for onward flow to Aeration
Tank No-2 (AT-2).
Periodically clean the outlet launder for foam and floating mass.
At every 6 hrs interval waste 0.55 kl of settled sludge from the clarifier bottom is
pumped to the sludge sump in PST. Before wasting stop recirculation from CF-1 to AT-
1 for about 15 minutes.
Draw a sample of clarified over flowing effluent daily.
7. Aeration Tank No-2 (AT-2)
Receive effluent on a continuous basis.
Run the air blower to continuously purge air into the effluent through fine bubble air
diffusers.
If required, spray the effluent over the liquid surface to arrest foaming.
Dose Micro flock (1 liter in 100 liter water) as a trickle over 12 hours at the AT-2
overflow launders. Maintain continuous additions round the clock.
Draw sample of the effluent slurry periodically.
Modify sludge wasting frequency so as to maintain mixed liquor suspended solids
(MLSS) at 2500 to 5000 PPM.
8. Clarifier No-2 (CF-2)
Receive the effluent slurry into the drum located in the center of CF-2.
Run the scrapper on a continuous basis. Run recirculation from CF-2 to AT-2 on a
continuous basis.
Periodically clean the outlet launder of CF-2.
At every 6hr. interval waste 0.55 kl of settled sludge from the clarifier bottom with the
aid of pump and transfer it to the sludge sump below TS. Before wasting stop
recirculation from CF-2 to AT-2 for about 15 minutes.
Draw a sample of clarified liquid overflow daily.
9 Holding Tank (HT)
Receive the effluent continuously.
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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Add 25-75kg of activated carbon daily @ 1-3 kg at the interval of one hour round the
clock.
Dose micro flock-90 (1 liter in 100 liter water) as a trickle over 12 hours at the AT-2
overflow launders. Maintain continuous additions round the clock.
Dose ferric chloride (0.3 kg in 200 liter water) as a trickle over 12 hours in holding
tank. Maintain batch additions as & when required.
Run the aerator for proper mixing in holding tank continuously for 5-10 minutes.
Stop the aerator for settling the flocks.
Start the pump to pass supernatant thru activated carbon filter.
Discharge the treated water in lawns.
Start the pump to feed sludge from holding tank to filter press.
DOMESTIC WASTE WATER
The total domestic waste water generated is 10.0 KLD. This quantity of waste water is treated
in properly designed Sewage treatment plant. The details and the schematic flow is appended
below.
SEWAGE TREATMENT PLANT
Process Scheme of Sewage Treatment Plant
Equalization Tank
The raw sewage collected in worker toilet sump thru bar and screen chamber for removal of
coarse and floating matters by trapping them in mesh. The screened sewage is passed through
the equalization tank to homogenize the characteristics by means of air agitation which help in
avoiding shock loading to the downstream process.
Aeration Tank
This homogenized sewage is pumped to aeration tank with the help of sewage transfer pump.
The aeration tank is designed on extended aeration activated sludge process to degrade the
organic matters by means of biological activity. The aeration tank is equipped with membrane
diffusers and blower assembly to provide atmospheric oxygen in to the sewage. The air
blowers are common for aeration process and equalization process.
Clarifier
The treated sewage from the aeration tank is taken in to the clarifier where the biomass is
settled with the help of polymer. The sludge settled in the clarifier is recycled back to the
aeration tank to maintain the desired level of mixed liquor suspended solids in with the help of
the pump.
Sludge Drying Beds
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Excess sludge is disposed of in the sludge drying bed for dewatering of sludge.
Chlorination Tank
The clear supernatant from clarifier is then transferred in to the chlorination tank for
disinfection by sodium hypochlorite added in tank by dosing pump.
Sand Filter
From Chlorination tank the treated effluent is pumped for filtration to the multi-grade filter.
Activated Carbon Filter
The effluent is further passed through the activated carbon polishing unit.
Treated Water Storage Tank
The finally treated water is stored in collection tank and pumped directly to the garden for
irrigation purposes.
Figure – 1: Schematic Flow Diagram of Sewage Treatment Plant
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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3.10 SCHEMATIC REPRESENTATIONS OF THE FEASIBILITY DRAWING WHICH GIVE
INFORMATION OF EIA PURPOSE
Project Concept
Form 1, Pre-feasibility Project Report with Proposed TOR to SEAC
Scoping by EAC (Site visit by sub group of EAC, if necessary)
TOR approved by SEAC EC - rejected by SEIAA on recommendation of SEAC
Draft EIA Report to SPCB
by Project Proponent
Public Consultation process by SPCB
Summary EIA and Form 1 – display
on the Website by SPCB
Proceedings of Public Consultation
Appraisal and Recommendation by SEAC
Display on MoEF&CCWebsite
Display at Panchayat, ZP, DM/DC/
Dy. Com & on the SPCB website
To Proponent for Submission of Final EIA
Report/Supplementary Report to Draft EIA
Approval by SEIAA
Rejected Approved Display on SEIAA Website& Project Proponent Website
Post EC
Monitoring
Submission of half yearly Compliance
Report to MoEF&CC/ RO-MoEF&CC
Display of Compliance Report
on MoEF&CCWebsite
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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4.0 SITE ANALYSIS
4.1 CONNECTIVITY
The site is located in the RIICO industrial area. All the amenities that are required for a stable
industry are available there.
Table 4: Connectivity
Particulars Name Distance, Direction
(From Project Boundary)
National Highway NH-1 20m,W
State Highway SH-16 7.15 Km, NW
Railway Station Diwana 2.59 Km, NNW
Airport Delhi International Airport 81.50 Km, S
4.2 LAND FORM, LAND USE AND LAND OWNERSHIP
4.2.1 LANDFORM
The unit is situated in the non -notified Industrial area. The proposes expansion and change
in product mix is coming within the existing premises. No additional land is required for the
expansion and change in product mix.
4.2.2 LAND USE
The proposed land use of the project is as under.
S.No Particulars Exiting
Area (SQM)
Proposed
Area
(SQM)
Total Area
(SQM)
Percentage
(%)
1 Buildings / Office / Warehouses
/QC/R&D / Workshop/ DG Room
/Manufacturing plants/ETP/RO
Plant/Boiler
18,163 1,400 19,563 58.83
2 Paved area/
Roads/corridors/parking
4,569 301 4,870 14.64
3 Green belt 6,700 -- 6,700 20.15
4 Open area 3,822 -1,701 2,121 6.38
TOTAL 33,254 -- 33,254 100%
4.2.3 LAND OWNERSHIP
The project is situated in non industrial area and duly converted for industrial use.
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
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4.3 TOPOGRAPHY (ALONG WITH MAP)
The topography of the district is flat surfaces with slight slopes running from North East
towards South and South West. It mostly has alluvial deposits which resulted from tectonic
changes effected due to Himalayan ranges. These deposits are composed of layers
originating from alluvial silt and sand. The Western Yamuna canal is exists at 3.72 km in
West direction of the proposed plant. There is no River in the near vicinity of 10 Km.
4.4 EXISTING LAND USE PATTERN (AGRICULTURE, NON-AGRICULTURE, FOREST, WATER
BODIES (INCLUDING AREA UNDER CRZ)), SHORTEST DISTANCES FROM THE
PERIPHERY OF THE PROJECT TO PERIPHERY OF THE FORESTS, NATIONAL PARK,
WILD LIFE SANCTUARY, ECO SENSITIVE AREAS, WATER BODIES (DISTANCE FROM THE
HFL OF THE RIVER), CRZ. IN CASE OF NOTIFIED INDUSTRIAL AREA, A COPY OF THE
GAZETTE NOTIFICATION SHOULD BE GIVEN.
The existing land use pattern is given in point no. 1.2.
4.5 EXISTING INFRASTRUCTURE
The existing project is a Lepro Herbals Private Limited, situated at G.T. Road Village-
Jattipur, Tehsil –Samalkha, Tehsil – Panipat, Haryana.
The land is duly converted (CLU) for Industrial use
Power is supplied almost uninterrupted from HSEB through an independent feeder.
There is availability of semi- skilled/skilled work force from the vicinity.
A. Physical Infrastructure
Physical Infrastructure is an important aspect of a city. It determines the quality of life to a
large extent. Physical Infrastructure deals with.
Water Supply
Electricity
Solid Waste disposal
B. Water supply
The water requirement is being met from existing bore well.
C. Solid Waste & Sanitation
All solid waste will be disposed of to the GEPIL site of Faridabad.
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 191
D. Electricity
The Unit is being fed through an independent feeder from the nearest Haryana State
Electricity Board. The unit has a total connected load of 810 kVA which is being supplied
Haryana State Electricity Board. There is no increase of electricity load envisaged after
expansion and change in product mix.
4.5.1 BASIC AMENITIES
The social infrastructure viz. hospitals, schools, places of worship, community facilities are
available in the study area. Habitation of Jattipur -500m,E is the nearest habitation. The
Location of the project is remote from the urban part of Panipat district but is an urbanizing
developing area.
4.6 SOIL CLASSIFICATION
The district has two types of soils viz-tropical arid brown and arid brown soils (solemnized).
The arid brown soils are found in major parts of the district whereas tropical arid brown
soils are found in north eastern part of the district especially in parts of Bapoli and Panipat
blocks.
4.7 CLIMATE
The climate of the district can be classified as sub tropical and semi arid. The area receives
normal annual rainfall is about 680 mm which is spread over 31 rainy days. 77% of rainfall
occurs during south-west monsoon. The normal annual rainfall of district based on average
of 5 years (2006-2010) has been computed as 591 mm.
4.8 SOCIAL INFRASTRUCTURE AVAILABLE
The well-established social infrastructure like hospitals, temple, community centre, roads,
bridges, telecommunication and others similar are available/ existing within 15 km radius..
5.0 PLANNING BRIEF
5.1 PLANNING CONCEPT (TYPE OF INDUSTRIES, FACILITIES, AND TRANSPORTATIONETC.)
TOWN AND COUNTRY PLANNING/ DEVELOPMENT AUTHORITY CLASSIFICATION.
The Bulk Drugs and Chemical industry is aptly described as the “Life Saving Industry”
signifying the crucial role its products play in alleviating human suffering from diseases and
controlling the various epidemics with pose and endemic danger to human civilization.
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 192
Keeping in view the apparent consumption for pharmaceutical formulations and existing
production capacities in the state and adjoining areas.
5.2 POPULATION PROJECTION
There will be recruitment of additional 34 workers as per requirement in operational phase.
The existing project has employed a work force of 198 workers. Hence the projected
population shall marginally augment by 34 workers only and shall not contribute major
increase in local area population.
5.3 LAND USE PLANNING (BREAKUP ALONG WITH GREEN BELT ETC.)
S.
No
Particulars Exiting
Area (SQM)
Proposed
Area
(SQM)
Total Area
(SQM)
Percentage
(%)
1 Buildings / Office / Warehouses
/QC/R&D / Workshop/ DG Room
/Manufacturing plants/ETP/RO
Plant/Boiler
18,163 1,400 19,563 58.83
2 Paved area/
Roads/corridors/parking
4,569 301 4,870 14.64
3 Green belt 6,700 -- 6,700 20.15
4 Open area 3,822 -1,701 2,121 6.38
TOTAL 33,254 -- 33,254 100%
The existing unit has approximately 20.15% total land area in green belt and plantation. The
remaining greenbelt will be done outside the plant premises boundary in school, panchayt ,
along the road side. The main aim of the green belt development is to improve the ecosystem
to a maximum possible extent by designing the green cover with the same native species.
However, in order to compensate the loss of vegetation, it is suggested to carry out extensive
afforestation program mainly in and around the project area. Appropriate plant species of
different life forms have been suggested in the following table to grow and to re-establish the
vegetation cover and thereby provide habitat for the faunal species. The list of plant species
suggested includes the following criteria:-
Tree species which are well adapted to local environmental setting, tall, bearing larger
canopy cover and leaf area.
Tree species of different size classes (small, medium and larger) were suggested to
maintain the different canopy levels at vertical profile.
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 193
Fruit trees in the selection list would help to attract birds and fruit eating bats which
are locally available.
Wild species were suggested to provide habitat for faunal species, increase the faunal
species diversity and maintain the naturalness.
5.4 ASSESSMENT OF INFRASTRUCTURE DEMAND (PHYSICAL AND SOCIAL)
On the basis of the preliminary site visit, the infrastructure demand in the villages assessed on
the basis of need and priority. The health infrastructure of the study area requires
improvement. The assessment will be identified in the socio economic survey, after the grant
of TOR and will be submitted at the time of final presentation regarding EC.
5.5 AMENITIES/ FACILITIES
As there is no major construction activities to be proposed. However necessary amenities will
be provided if required.
6.0 PROPOSED INFRASTRUCTURE
6.1 INDUSTRIAL AREA (PROCESSING AREA)
The area is very well connected by road network to the site, district headquarter etc. The area
is self sufficient to cater the needs of the project. Hence, no infrastructure is proposed.
6.2 RESIDENTIAL AREA (NON PROCESSING AREA)
No housing facility has been proposed.
6.3 GREEN BELT
The same has been given in point 5.2.
6.4 SOCIAL INFRASTRUCTURE
The existing project is situated at Tehsil –Samalkha, District – Panipat (Haryana). Local
population is employed by the company in the project. Further, indirect means of earnings
have been created in the area of contractual jobs, vehicle driving, shops, construction etc.
Therefore, this project brought a positive impact on the adjoining society. The proponent is
being spent 1% of profit for the development of the area i.e. medical facilities, schools, temples
and other social work. There is well developed social infrastructure in the area; detail has
been tabulated in section – III of Form – 1.
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 194
6.5 CONNECTIVITY (TRAFFIC AND TRANSPORTATION ROAD/ RAIL/ METRO/WATER WAYS
ETC.)
Given in point no. 4.0.
6.6 DRINKING WATER MANAGEMENT (SOURCE AND SUPPLY OF WATER)
Given in point no. 3.8.1.
6.7 SEWERAGE SYSTEM
For the treatment of domestic sewage, STP (10 KLD) has already provided with adequate
capacity in existing plant.
6.8 INDUSTRIAL WASTE MANAGEMENT
The company has already provided ETP (25KLD) for treatment of industrial waste water.
The up gradation of the ETP (35KLD) and the scheme for ZLD is proposed in order to comply
the norms .
6.9 SOLID WASTE MANAGEMENT
The same has been given in point no. 3.9.1.
6.10 POWER REQUIREMENT AND SUPPLY/ SOURCE
The same has been given in point no. 4.5.
7.0 REHABILITATION AND RESETTLEMENT (R & R PLAN) : Not applicable
7.1 POLICY TO BE ADOPTED (CENTRAL/STATE) IN RESPECT OF THE PROJECT AFFECTED
PERSONS INCLUDING HOME OUSTEES, LAND OUSTEES AND LANDLESS LABOUR (A
BRIEF OUTLINE TO BE GIVEN)
Since, it is an existing project and there is no habitation in the unit area, therefore
rehabilitation & resettlement plan is not required/ applicable.
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 195
8.0 PROJECT SCHEDULE AND COST ESTIMATES: Rs. 51.11Cr.
8.1 LIKELY DATE OF START OF CONSTRUCTION AND LIKELY DATE OF COMPLETION (TIME
SCHEDULE FOR THE PROJECT WILL BE GIVEN).
The construction phase in this project is likely to commence in after the obtaining statutory
approval from the concerned departments. In the meanwhile, the changes in the product mix
can be initiated.
8.2 ESTIMATED PROJECT COST ALONG WITH ANALYSIS IN TERMS OF ECONOMIC
VIABILITY OF THE PROJECT.
The expected capital investment for the Proposed expansion with change in product mix
cost is Rs 870Lacs.
9.0 ANALYSIS OF PROPOSAL
9.1 FINANCIAL AND SOCIAL BENEFITS WITH SPECIAL EMPHASIS ON THE BENEFITS TO
THE LOCAL PEOPLE INCLUDING TRIBAL POPULATION, IF ANY, IN THE AREA.
There have been many social benefits from the existing manufacturing operations. The
underlying financial and social benefits envisaged through the existing plant have been
listed as follows:-
Table 10: Financial & Social Benefits
S. No. Activities
1. It aims to provide few additional employments to the local population of the proposed study
area.
Existing Direct employment provided: -198 Approx.
Indirect Employment to locals :- 25 + 25 Approx.
The proposed expansion with change in product mix aims to continue the sustainable social
development. The Project authorities are committed towards fulfilling social responsibility.
As per the Companies Act 2013 , The CSR would be applicable for every company having net
worth of Rs. 500 crore or more, or turnover of Rs. 1000 crore or more or a net profit of Rs. 5
crore or more during a year, such Companies shall be required to ensure that every year at
least 2% of its average net profits during the three immediately preceding financial years is
spent on CSR activities as may be approved and specified by the company. Lepro Herbals
Pvt. Ltd. is not under the threshold limit applicable for mandatory CSR. However, The project
understands its responsibility towards the society and therefore has been undertaking many
projects for sustainable development (few of which are given below).
PROJECT : EXPANSION AND CHANGE IN PRODUCT MIX OF EXISTING HERBAL EXTRACTS AND THEIR PURIFIED DERIVATIVES FOR MANUFACTURING OF HERBAL EXTRACTS AND ACTIVE PHARMACEUTICALS INGREDIENTS
PRE-FEASIBILITY REPORT
APPLICANT : LEPRO HERBALS PVT. LTD
DOCUMENT NO.: EESPL/LHPL/008/EC/Ind./2018-19/431
ENKAY ENVIRO SERVICES PVT. LTD., JAIPUR
APRIL’2018 196
After the analysis of the baseline data generation, socio – economic survey, and the public
hearing, the appropriate sustainable development plan will be contributed on the basis of
need based analysis, projected by the corporation.
The appropriate amount of CSR will be proposed by the Lepro Herbals Private Limited with
its applicability as per the Companies Act, 2013 with an appropriate 2% of the next three
years average annual net profits of the coming years.
10.0 CONCLUSION
Lepro Herbals Pvt. Ltd. proposes expansion with change in the product mix for
manufacturing of herbal extracts and active pharmaceuticals ingredients in existing plant
area of 33,254Sq.m. No additional land is required. The total capital investment till
31.03.2017 of Lepro Herbals Pvt. Ltd. plant of Herbal Extract & Its Purified Products is
3,537.98Lacs. The project is not only contributing to the growth of Indian economy but also
strengthen the socio-economic values/ status in the area. All the latest and environment
friendly technology is adopted. The unit is already adopting all measures like; pollution
control equipments, effective EMP & DMP to prevent harm/ damage to the environment.
Green belt development in & around the area is increase aesthetic value, as tool for effective
pollution mitigate measure, and are also serve as biological indicators for that particular site.
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