Pre-Feasibility Report - Welcome to...

Cadila Healthcare Limited 0

Pre-Feasibility Report


1. INTRODUCTION

M/s. Cadila Healthcare Limited proposes to manufacture Bulk Drugs at Masar

Block No –1162-1164, 1171-1174, 1181-1183 and Kanzat Block No –1115-

1120, 1122, 1126, 1159-70, 1207, Masar-Kanzat, Tehsil: Padra, Dist.

Vadodara.

2. COST OF PROJECT

The estimated cost of the project for the proposed project is estimated around

Rs. 200 crores. Out of this around Rs. 11.38 crores will be invested for

pollution control measures.

3. PRODUCTION CAPACITY

Production capacity is prescribe below:

List of products

Sr.

No.

List of product Quantity

(MTPM)

Quantity

(MTPA)

1 Acotiamide hydrochloride

20 240

2 Agomelatine

3 Anagrelide Mono hydrochloride

Monohydrate

4 Anastrozole

5 Apixaban

6 Apomorphine HCl

7 Apremilast

8 Aripiprazole

9 Atenolol

10 Atomoxetine HCl

11 Trazodone

12 Atorvastatin Calcium

20 240

13 Atovaquone

14 Avanafil

15 Azelastine HCl

16 Azilsartan Medoxomil

17 Bisacodyl

18 Bosentan

19 Brexpiprazole

20 Bupropion HCl

21 Buspirone HCl

22 Brivaracetam

23 Canagliflozin

24 Candesartan Cilexetil


25 Carvedilol

26 Clindamycin

27 Clonidine

28 Clopidogrel Bisulphate/ besylate

20 240

29 Colestipol Hydrochloride

30 Cinacalcet HCl

31 Dapagliflozin

32 Darunavir

33 Desloratadine

34 Desvenlafaxine succinate

35 Dimethyl Fumarate

36 Donepezil HCl

37 Duloxetine Hydrochloride

38 EdoxabanTosylate Monohydrate

39 Eltrombopagolamine

40 Empagliflozin

41 Entecavir

42 Escitalopram Oxalate

43 Esomeprazole Magnesium

44 Ethacrynic acid

20 240

45 Etoricoxib

46 Famotidine

47 Fingolimod

48 Flibanserin

49 Fluconazole

50 Fosphenytoin Sodium

51 Gabapentine

52 Glimepiride

53 Hydrochlorothiazide

54 Hyoscyamine Sulfate

55 Ivabradine Hydrochloride

56 Levomilnacipran

57 Hydroxychloroquine sulfate

20 240

58 Lamotrigine

59 Lansoprazole Sulphide

60 Ledipasvir

61 Letrozole

62 Levofloxacin Hemihydrate

63 Linagliptine

64 Loratidine

65 Lorcaserin HCl

66 Losartan Potassium


67 Lurasidone hydrochloride

68 Macitentan

69 Meloxicam

70 Mesalamine

20 240

71 Metoprolol succinate

72 Midodrine HCl

73 Mirabegron

74 Nicronadil

75 Olmesartane

76 Omeprazole / Omeprazole Magnesium

77 Pantoprazole Sodium

78 Paroxetine Hydrochloride

79 Phenteramin

80 Pramipexole Dihydro Mono Hydrate

81 Pregabalin

20 240

82 Propefenone

83 Polmacoxib

84 Quetiapine Hemifumarate

85 Ranolazine

86 Rasagilinebesylate

87 Risperidone

88 Rivastigmine

89 Roflumilast

90 Rosuvastatin calcium

91 Rosuvastatin ethanol amine

92 Sacubitril Valsartan Trisodium

93 Saroglitazar

94 Saxagliptin

95 Setraline Hydrochloride

96 Sildenafil citrate

97 Silidosin

98 Sitagliptin phosphate

Anhydroous/Besylate

99 Sparfloxacin

100 Tamsulosin HCl

101 Tebipenem pivoxil

102 Telapvir

103 Telmisartan

104 Tenegliptin

105 Amlodipine Beyslate

25 300 106 Etodolac

107 Tirofiban HCl


108 Tofacitinib Citrate

109 Tolvaptan

110 Topiramate

111 Tramadol Hydrochloride

112 UDCA (India Market)

113 Valdecoxib

114 Valsartan

115 Venlafaxine Hydrochloride

116 Vilazodone hydrochloride

117 Vildagliptin

118 Vortioxetine Hydrobromide

119 Warfarin sodium clathrate

120 Ziprasidone HCl

121 Azathioprine

10 120

122 Febuxosate

123 Lacosamide

124 Refaximin

125 Tolperison

126 Udenafil

127 R&D Products /Pilot Plant

batches/Development Batches 2 24

TOTAL 177 2124


4. List of Raw Materials

Sr.

No.

List of Product List of Raw Material Quantity

(MT/MT)

1. Acotiamide HCl 2,4,5-Trimethoxy Benzoic acid 0.870

Toluene 0.380

Thionyl Chloride 1.200

DMF 0.590

Ethyl 2-Amino Thiazole-4-carboxylate 0.520

Pyridine HCl 0.620

Pyridine 0.550

Acetic acid 6.990

N,N Diiso propyl ethylene diamine 1.460

MDC 0.660

Ethyl acetate 0.210

Isopropanol 3.160

IPA-HCl 0.830

Ethanol 4.000

2. Agomelatine 7-methoxy naphthyl acetic acid 1.160

Methylene dichloride 0.560

Thionyl chloride 0.760

Aqueous ammonia 0.980

Trifluoro acetic anhydride 2.580

Tetrahydrofuran 0.300

Methanol 0.380

Raney Nickel 0.200

Ammonia 0.350

Hydrogen 0.050

Hyflow 0.200

Pyridine 2.910

Acetyl chloride 0.660

3. Anagrelide

Monohydrochloride

Monohydrate

2,3 dichloro-6-Benzonitryl derivative 2.000

Bf3 etharate 1.480

Hydrochloric acid 2.800

Sodium Borohydride 1.200

Ethyl acetate-HCl 2.920


Ethyl acetate 0.900

Ethyl bromo acetate 0.920

Catalyst 0.240

Sodium carbonate 0.700

NN DMF 2.000

Isopropyl alcohol 0.050

Stannous Chloride 0.520

Con. HCl 1.000

Sodium hydroxide 0.500


Cyclizing agent 0.800

Toluene 0.080

Triethyl amine 0.800

Ethyl alcohol 0.250

Activated Charcoal 0.160

Celite 0.400

4. Anastrazole 4-Amino-1,2,4-triazole 0.310

Isopropanol 0.230

3,5-Dicyanotertramethyl-alpha-bromo

Toluene 1.300

Sodium Nitrite 0.500

HCl 1.000

Toluene 0.520

Cyclohexane 0.390

Ethyl acetate 0.130

5. Apixaban MNDP 0.570

CMPHEA 0.580

TEA 0.400

Ethyl acetate 0.500


HCl 0.300

Iron Powder 0.570

Ammonium chloride 0.300

Methanol 0.820

MDC 0.200

cyclohexane 0.030

Hyflow 0.580

Ammonia gas 1.600

5-CVC 0.820

TEA 0.640

NaOH 0.370

DMAc 1.220

activated carbon 0.060

DMSO 5.280

6. Apomorphine

Hydrochloride

Morphine HCl 1.250

Ammonia 0.400

Phosphoric acid 5.460

Phosphorus pentoxide 1.770

Sodium Sulphate 10.000

Isopropyl Acetate 2.000

Sodium meta bisulfite 6.000

IPA HCl 2.400

Isopropyl Acetate 2.200

Ethanol 0.500

7. Appremilast 3-Nitrophthalic acid 0.370

(S)-1-(3-ethoxy-4-methoxyphenyl)-2- 0.250


(methyl sulfonyl)-ethan-1-amine [(S)-

EMME]

Acetic Acid 0.380

IPA 0.100

10% Palladium Charcoal 0.300

Ethyl Acetate 0.300

Dichloromethane 0.040

Acetyl chloride 0.500

Potassium Carbonate 0.200

Methanol 0.060

Sodium Bicarbonate 0.300

THF 0.050


Isopropyl Alcohol 0.050

Acetone 0.900

8. Apriprazole 7-Hydroxy-3,4-Dihydrocarbostyryl 0.650

1,4 Dibromo butane 3.450

Potassium carbonate 0.600

Acetone 0.240


Charcoal 0.240

Ethyl acetate 0.060

Cyclohexane 0.130

1-(2,3-Dichlorophenyl) piperazine HCl 1.150


Methanol 0.800

IPA HCl 0.960

Sodium hydroxide solution 0.250

Ethanol 0.280

9. Atenolol 4-Hydroxy Phenyl Acetamide 0.520

Sodium Hydroxide 0.490

Epichlorohydrin 0.630

Isopropyl amine 5.020

TEBAC 0.020


Celite 0.180

Activated charcoal 0.060

10. Atomoxetine HCl N,N-dimethyl-3-phenyl-3-hydroxy-3-

propyl amine 1.040



Acetone 0.300


2-Methyl phenol 0.250


Toluene 0.400



Phenyl chloroformate 0.730


Potassium hydroxide 0.230

Methanol 0.080

Oxalic acid 0.260

Liq. Ammonia 1.080

n-Butyl acetate 3.920

L-(+)-Mandelic acid 0.250


Ethyl acetate 0.180

IPA-HCl 0.150

11. Trazodone TVA-Chloro propyl phenyl piperazine 0.910

TVA-Triazolo pyridine 0.410


IPA 0.620

HCl 0.670

Methanol 0.280

12. Atorvastatin Calcium Isopropyl alcohol 0.500

Z/E Compound 1.000

p-floro Benzaldehyde 0.450


Toluene 0.250

Raney Ni 0.300

H2 (g) 0.200

NH3 (g) 1.200

Methanol 1.980

Hyflow 0.500

Pivalic acid 0.110

THF 0.100

Cyclohexane 0.110

Sodium bicarbonate 0.080

1N HCl 1.590


Di isopropyl ether 0.090

Calcium chloride 0.140

13. Atovaquone 4-(4-chlorophenyl)cyclohexane-

carboxylic acid 0.830

2-chloro-1,4-nepthaquinone 0.660

Silver Nitrite 0.170

Ammonium persulphate 1.590

Acetonitrile 6.230

MDC 0.710

Charcoal 0.100

Hyflow 0.920

KoH 0.650


Methanol 0.350

HCl 2.050

Xylene 0.200

Acetone 0.500

14. Avanafil Acid compound (KSM-I) 0.900

ANK-KSM-II 0.570

EDC HCl 0.530

HOBT 0.030

Tri ethyl amine 0.300

DMF 0.180


15. Azelastine HCl Sodium Hydroxide 1.210

ATA-02 1.000

2-(2-Chloroethyl)-1-methyl

pyrrolodone Hydrochloride 0.730

Toluene 3.080

Charcoal 0.010

Acetone 0.230

HCl 0.190

Acetonitrile 0.200

16. Azilsartan

Medoxomil

OTBN 1.000

Sodium Ethoxide 1.900

Hydroxyl amine Hydrochloride 1.870

DMSO 4.720

ECF 0.620

TEA 0.670

MDC 0.170

HCl 0.020

DMF 5.310

DBDMH 1.130

AIBN 0.040

Ethyl acetate 0.110

Cyclo Hexane 0.300

2-Etoxy benzimidazole 7-carboxylic

acid methyl ester 0.020

Methanol 0.100


Toluene 0.030

MMA 0.350

p-Toluene sulfonyl Chloride 0.620


Acetone 0.110

17. Bisacodyl Toluene 0.250

HCl gas 0.020

Phenol 2.250

Pyridine 2-aldehyde 1.250


Sodium carbonate sol 0.630

Methanol 0.400

Acetic acid 1.750

Acetic anhydride 0.460

18. Bosentan 2-Methoxy phenol 0.640

2-Chloro dimethyl malonate 0.920

Methanol 0.420

sodium metal 1.100

Toluene 0.370

1 % NaOH 0.630

2-pyrimidine imidamide 0.770

HCl 8.660

Acetonitrile 0.100

POCl3 0.050

MDC 0.320

Saturated Sodium bicarbonate 1.000

Sulphonamide 0.770

DMSO 0.240

Ethyl acetate 0.480

Ethylene glycol 0.140

19. Brexpiprazole 1-(benzo[b]thiophen-4-yl)piperazine

Hydrochloride (KSM-I) 0.730

1,4-dibromobutane 0.650


Methanol 0.120

Toluene 0.400

7-Hydroxy quinolinone (KSM-II) 0.650


Dimethyl formamide 0.240

THF 0.220

20. Bupropion HCl 3-Chloropropiophenone 0.150

Liquid Bromine 0.150


Sodium Thiosulphate 0.040

Celite 0.010

Tertiary Butyl amine 0.650

Iso Propyl Alcohol 0.370

IPA: HCl 0.060

Charcoal 0.010

Celite 0.010

21. Buspirone HCl 2-(piperazin-1-yl) pyrimidine 0.420

1,4-dibromo butane 0.160


Dimethyl Formamide 0.050

HCl 0.030



8-azaspirol[4.5]decane-7,9 dione

(1,2,3,4-tetra methylene glutamide) 0.450

n-butyl acetate 0.550

22. Brivaracetam S-+-2-phenylglycinol 0.450

Diethyl Carbonate 0.160


Ethyl acetate 1.640

Pivaloyl chloride 0.330

n-Valeric acid 0.660



Conc. HCl 0.610

1M NaHMDS 1.230

Tert-butyl bromo acetate 0.880


Cyclohexane 0.040

Hydrogen peroxide (30%) 0.470

Lithium Hyrdroxide monohydrate 0.640

Sodium sulfite 0.170


Toluene 1.760

S-(-)-α-Methyl benzyl amine 0.580

Toluene 0.200


Toluene 0.620

Ethyl chloro formate 0.180



Methanol 0.060

Trifluoro acetic acid 1.000

HBr 0.330

(S)-2-Aminobutyramide hydrochloride 0.200


TEA 0.330

Ethanol 0.200

Sodium Chloride 0.150

Sodium sulfate 0.130

n-Heptane 0.380

THF 0.230

Potassium-tert butoxide 0.080


Ethyl acetate 0.450

Isopropyl acetate 0.160

23. Canagliflozin CGA-02 0.950

CGA-03 1.140

THF 0.140


n-Butyl lithium 0.060

Methane Sulfonic acid 0.670

Methanol 0.320

Toluene 0.910


n-heptane 2.770


TMSCl 0.280

MDC 4.960

NMM 0.030

NaH2PO4.2H2O 0.500

Sodium Sulfate 0.210

Hyflow 0.860

BF3 Etherate 1.200

Triethyl silane 0.880

BHT 0.070


Ethyl acetate 0.480


Hyflow 0.300

Beta cyclodextrin 0.290

isopropyl acetate 0.470

MTBE 4.020

Ethanol 0.220

L-proline 0.370

24. Candesartan

Cilexetil

CN-13 1.000

Cilexetil 0.350


DMSO 2.500

Pivalic acid 0.240

Methanol 8.500

MDC 8.720

P.W. 4.100


Ethanol 0.170

Cyclohexone 0.220

25. Carvedilol 4-(2,3-Epoxy)-9H-Carbazole 0.063

2-(2-2-Methoxyphenoxy) Ethyl Amine 0.045


Salicylic acid 0.036

Ethyl Acetate 0.044

Caustic Flakes Soda 0.008

Hyflow Super cell 0.003

Activated Carbon 0.012

26. Clindamycin Lincomycin HCl 1.110

Chloroform 1.420


DMF 0.030



MDC 0.080

Ethanol 1.400

HCl 4.660

Charcoal 0.010

Acetone 0.060

27. Clonidine 2,6-Dichloro Aniline 1.170

Ammonium thiocyanate 1.100

Trifluoro acetic acid 2.480

Toluene 0.750

TEA 1.470

Ethyl acetate 0.380

Isopropanol 0.500

Methyl Iodide 0.620

Acetone 0.070

Cyclohexane 0.990

Ethylene diamine 3.700

DMSO 1.870

28. Clopidogrel

Bisulphate/ besylate

2-CPG 0.830

Methanol 0.310

thionyl chloride 0.250

toluene 1.580

Liquid ammonia 2.030

acetone 0.440

L(+) tartaric acid 0.720

15% NaCl solution 2.790

K2HPO4 0.620

acetonitrile 0.180

Ethyl acetate 2.990

HCl solution 0.650

Sulfuric acid 0.270

Charcoal 0.090

29. Colestipol

Hydrochloride

Diethyl enteric amine 0.830

Sodium dodecyl benzene sulphonate 0.020

Toluene 0.130


NaOH solution 0.430

30. Cinacalcet HCl R--1-Napthalen-1-yl)ethylamine 0.550

4-(3-(trifluoro methyl ethyl)

phenyl)butane-2-one 0.650

Titanium(IV) isoperoxide 0.880



Pd/C 0.040


Ethanol 5.070

HCl 0.170

31. Dapagliflozin DGA-Ethoxy benzyl 0.860


n-BuLi(23% in hexane) 0.820

Methane sulphonic acid 0.650

DGA-Glucono Lactone (KSM-2) 0.210

Methanol 3.750

sodium bi carbonate 0.510

n-heptane 0.170

charcoal 0.090

MDC 0.210

Sodium chloride solution 0.520

Triethyl silane 0.730

Boronitriflouride diethyl ether 1.210

ethyl acetate 1.860

Sodium chloride 0.330

Hyflow 0.560

MTBE 0.380

DIPE 0.570

Butanediol for seeding 0.010

1,2 Butanediol 0.870


32. Darunavir Methanol 0.070

KSM-1 (BOC-07) 0.110

con HCl 0.410

Sodium carbonate solution 0.360



KSM-02 0.630

Ethyl Acetate 0.390

10% Pd/c 0.120


33. Desloratadine Loratadine 1.000

Ethyl Chloroformate 0.490

Toluene 0.160


Methanol 0.330

34. Desvenlafaxine

Succinate

venlafaxine 5.320

PEG-400 3.740

Sodium thiophenolate 6.330

H3PO4 2.400

n-Heptane 3.750

Liquid Ammonia 0.660

Succinic acid 0.380

Acetone 0.350


35. Dimethyl Fumerate Fumaric Acid 1.000

Methanol 3.000


36. Donepzil HCl 5,6-Dimethoxy 1- indanone 0.660


1-Benzyl 4-piperidine carboxaldehyde 0.830

sodium methoxide solution 0.040

Methanol 1.980


IPA HCl 0.130

Diisopropyl ether 3.550

DNZ 1.130

5% NaOH solution 0.560

Methanol 0.980

Acetic acid 4.720

10% Palladium on charcoal 0.020

Hyflow 0.200

Liquor ammonia 1.500

5% Acetic acid solution 3.400

5% NaCl solution 1.100


37. Duloxetine HCl 2-Acetyl Thiophene 0.640

Pera formaldehyde 0.180

Dimethyl amine Hydrochloride 0.500

IPA 0.170

Conc. HCl 0.030


NaOH 0.230

Methanol 0.090

1-Fluoro Naphthol 0.540

KOH 0.320

DMSO 1.550

Toluene 0.900

Hyflow 0.130

Triethyl Amine 0.440

Phenyl Chloroformate 0.600

K2CO3 1.350

L(-)DBTA 0.680

Ethanol 0.440

NaOH 0.110

MDC 0.410

38. Edoxaban Tosylate

Monohydrate

ACO 0.900

CPA 0.700

TEA 0.070

DMAc 4.250



IPA HCl 2.320

TPC 0.540

DIPEA 0.060

TBTU 0.730

MDC 0.070


Hyflow 0.170

Ethanol 0.730

PTSA.H2O 0.280


39. Eltrombopagalamine Sodium Nitrite solution 0.420

sulphuric acid 1.020

4-chloro 2-bromo phenol 1.010

Methanol 0.080

potassium carbonate 0.910

Benzyl Chloride 0.770

DMF 0.090

3 carboxy phenyl boronic acid 0.550


Palladium tetrakis triphenylphosphine 0.050

toluene 0.160

HCl 3.940

Palladium carbon 0.100

Acetone 8.130

Acetic acid 2.300

3,4-dimethylphenyl hydrazine HCl 0.600

Sodium acetate 0.280

Ethyl aceto aetate 0.450

MDC 0.080

Sodium bicarbonate solution 0.290


Amino biphenyl 3.600

ELA- KSM-3 1.200

Sodium Nitrite 0.600


Ethanol 2.580

THF 0.050

Ethanol amine 0.060

40. Empagliflozin Dichloromethane 1.040

4-bromo 1- chloro 2-(4-

ethoxybenzyl)benzene 0.800

boron tri bromide 0.390

Triethyl chloride 0.700

triethyl amine 0.360

MTBE 0.200

EMA-Trityl 1.700



Methanol 0.550

Methane sulfonic acid 1.320


Heptane 0.120

Toluene 1.000

Ethyl Acetate 0.710

Acetonitrile 0.300

Boron Trifluoride.Et2O 0.710

Triethysilane 0.640

Methyl Ethyl Ketone 4.330

Methyl tertiary butyl ether 1.380

Cyclohexane 0.110

EMA-Condensed Phenol 0.500

EMA-Tosylate 0.500

Cesium Carbonate 0.450

N,N-dimethyl formamide 0.190



Ethanol 0.150

L-Proline 0.750

41. Entecavir

Monohydrate

Entecavir KSM 1.820

Boron trichloride 1.660

MDC 0.220

Methanol 0.400

Ethyl acetate 0.290

NaOH 0.360


Hyflow 0.200

42. Escitalopram

Oxalate


CDO-Hydrobromide 1.810

Dichloro Methane 0.810


(+)DI-tolyl tartaric acid 0.820

Methylene Chloride 0.590


Methane Sulphonyl chloride 0.190


Oxalic acid 0.130

Acetone 0.400

43. Esomeprazole

Magnesium

chloro compound (NRD-17) 0.680

methanol 0.680

mercapto compound 0.570

NaOH flakes 0.280

MDC 0.200

Ethyl acetate 0.450


Diethyl-L-tartarate 1.300

Titanium Isopropoxide 0.880

Diiso propyl ethylamine 0.030

Cumene Hydroperoxide 1.040

Isooctane 0.110

10 % NH3 Solution 1.350

30% HCl Solution 0.990

MDC 0.480

44. Ethacrynic Acid 2,3-Dichlorophenol 1.110


Dimethyl sulfate 3.010


n-Butyryl chloride 1.390

Anhy. Aluminum chloride 3.480

HCl Solution (3.0%) 3.310

Diisopropylether 0.230

N,N-Dimethyl formamide 1.400

Ethyl chloro acetate 0.460


Ethyl 2-(4-Butyryl-2,3-

Dichlorophenoxy) acetate (Stage-3) 1.000


Methanol 0.620

Dimethyl amine hydrochloride 0.580

Paraformaldehyde 0.220

Acetic acid 0.100


Toluene 0.500


Celite 0.180

45. Etoricoxib Chloro acetic acid 0.380


Hexafluoro phosphoric acid 1.170

1-(6-Methyl-3-pyridinyl)

2-[4-(methyl sulfonyl)

phenyl]ethanone

1.000

Potassium butoxide 0.400


46. Famotidine Methanol 0.070

Caustic flakes 0.750

Isothiourea HCl 1.170

Propionamide derivative 1.040

Acetic acid 0.380

Ammonia gas 0.180

charcoal 0.080

Celite 0.040



47. Fingolimod Iodo Compound 1.250

Diethyl acetamidomalonate 1.650

Sodium hydride 0.300

Dimethyl Formamide 0.680

Diiso propyl ether 0.260

Trifluoroacetic acid 2.270

Triethylsilane 0.730



Dipothydrogen Phosphate 2.720

Ethanol 0.400

Ethyl acetate 0.220

Lithium Hydroxide 0.600

Methanol 0.260

Acetonitrile 1.280

Ethereal HCl 2.700

48. Flibanserin Orthophenylene diamine 1.000

Ethyl acetoacetate 1.320

KOH (85%) 1.100

Acetic acid 1.660

Methanol 0.300

Mix. Xylene 0.180

1,2-dichloro ethane 3.480


TBAB 0.020

Toluene 3.260

FSK-pip.deriv. 0.950

DMF 0.150

KI 0.060

FSK-alkene 1.000

IPA HCl 1.770

IPA 0.260


MDC 0.210

49. Fluconazole CT Base 1.400

TMSI 1.400

IPA 0.150

KOH 1.000

1:2:4 Triazole 0.700

MDC 0.280

Hydrose 0.010

Carbon 0.140

Hyflow 0.300

Acetone 0.650

Ethyl acetate 0.750


Methanol 1.390

50. Fosphenytoin

Sodium

Sodium phonytoin 1.000

HCl 0.700

K2CO3 0.010

HCHO 0.500

SDS 1.440


DMF 0.020

NaHCO3 0.400

EtOAC 1.030


Hexane 0.650

Phosphorus Trichloride 0.710

Benzyl Alcohol 1.110

dimethyl aniline 1.250

Benzene 0.160

brine Solution 1.300

Ammonia Solution 0.780

Carbon tetra chloride 0.860

NaOH solution 2.180

Silver nitrate 0.560

Nitric Acid 0.110

Toluene 0.220


Potassium Carbonate Solution 2.600

51. Gabapentine Gaba Mesylate 4.000


HCl 1.500

Methanol 0.190

Acetone 0.170

Dichloro methane 0.200

Ethyl amine 0.800

Celite 0.010

Charcoal 0.010

52. Glimepiride Triethyle Amine 0.330

4 MCH amine hydrochloride 0.430

Carbamate pure 1.000

Toluene 1.310

Dilute HCl 0.400

Caustic soda Pallets 0.120

Methanol 1.770

53. Hydrochlorothiazide caustic soda 1.630

sulfonamide 6.420

carbon 0.110

sulphuric acid 0.110

54. Hyoscyamine Toluene 0.250


Sulfate Ethyl phenyl acetate 0.710

Sodium Hydride 0.390

Acetic acid 0.780

Tropine 0.550

Ethyl formate 0.960





Dibenzoyl-L-tartaric acid monohydrate 1.450

Ethanol 0.440


Hyflow 0.330

acetone 0.450

Hyoscyamine Sulfate 0.010

sulfuric acid 0.200

55. Ivabradine HCl S(+)benzo cyclo butene 0.830

Bromo chloro propane 3.750

K2CO3 0.820

HCl 2.500

MDC 1.270

NH3 1.660

ID-B 0.560

DMSO 2.410

Pot. Tert. Butoxide 0.320

Ethyl acetate 0.150

Aceto nitrite 0.230

IPA HCl 1.630

56. Levomilnacipran Toluene 1.820

aluminium chloride 0.620

Dimethyl amine 0.710

Lactone compund 0.680

HCl 0.200

DMF 0.070


Potassium Phthallamide 0.940

Cyclohexane 1.270

IPA 0.080

Monomethyl amine 1.500

( R)' Mandelic acid 0.560

LEA Mandelate salt 0.010

ethyl acetate 0.310

MDC 0.350

NaOH Solution 0.260

IPA-HCl 0.070

57. Hydroxychloroquino 4,7-DCQ 1.250


ne Sulfate HNDA 1.060

Sod. Carbonate 0.620

Pot. Iodide 0.050

Ethyl acetate 0.280

Aq. NH4)2SO4 soln. 5.370

Gl. Acetic acid 0.330

Charcoal 0.060

Celite 0.190

Toluene 0.200

IPA 0.050

58. Lamotrigine AGB 1.100

2,3 dichloro benzyl cyanide 1.100

Sulphuric acid 3.300

NaOH Flakes 0.310

40% NaOH solution 0.770

Methanol 1.250

Acetic acid 4.460



Isopropanol 0.120

59. Lansoprazole

Sulphide

LN-01 0.780

methanol 3.980

2-Mercaptobenzimidazole (LN-02) 0.430


Sodium thiosulphate 0.270


MDC 7.670

m-Chloroperbenzoic acid 0.820

Dilute Acetic acid 0.420

MDC 3.250

IPA 5.670

liquid ammonia 0.600


Potassium Hydroxide 0.270

Acetic acid 0.140

60. Ledipasvir LSA KSM-01 0.760

LSA KSM-02 0.740

K2CO3 0.390

Pd Tetrakis 0.030

1,4-dioxane 5.930

Acetone 7.280

Methanol 0.080


IPA-HCl 3.020

MDC 0.600

Moc-L-Valine 0.540


EDC-HCl 0.590

HOBt 0.430

DIPEA 0.050

Dimethyl foramide 0.220

Ethyl Acetate 0.370

Acetone 0.260

Na2CO3 0.920

Sodium Sulphate 0.100


Copovidone 0.750

Methanol 0.560

61. Letrozole 4-Bromo methyl Benzonitrile 1.170

1,2,4-triazole 0.450


Methylene chloride 0.130

di isopropyl ether 0.210


4-Fluoro Benzonitrile 0.840

DMSO 5.370

potassium-t-butoxide 0.960

Toluene 0.310

Acetone 0.130

62. Levofloxacin

Hemihydrate

Absolute alcohol 6.000

DMSO 3.800

Levo acid 0.950

N-methyl piperazin 0.330

Tri ethyl amine 0.340

IPA 0.180

Ethanol 1.240

Liq. Ammonia 1.250

Acetic acid 0.750

63. Linagliptine BMP 0.080

2 bromo butyne 0.530

DIPEA 0.550

DMF 0.150

BMQ 0.640

Sodium Carbonate 0.350

NMP 0.270

Ethanol 0.220

acetic acid 0.030

R-BOC3-AP 0.440


DMSO 1.500

TFA 2.500

MDC 0.600

64. Loratidine 3CPAN 0.660


Sodium Methoxide 1.080

Methyl nicotinate 0.660

HCl 0.680

Acetic acid 0.140


liquid ammonia 0.970

Toluene 0.430

hydrazine hydrate 0.470


MEG 1.000

MDC 0.250

Acetic acid 0.940

H2O2 1.500

THF 0.170

Mg 0.120

Iodine 0.020

N-M4CPB 0.740

EDB 0.010

HCl 1.530

NaOH 0.720

HF 0.120

BF3 gas 0.060

KOH 0.760

ECF 0.720

TEA 0.770

NaHCO3 Solution 2.340

Acetonitrile 0.170

charcoal 0.080

Hyflow 0.100

65. Lorcaeserin HCl Dichloromethane 0.350


4-chloro phenyl acetic acid 0.780

DMF 0.110

Phosphorous pentachloride 1.460

1-amino 2-propanol 0.520



Sodium borohydride 0.270

LLA-Chloro amide 1.170

BF3 etharate 1.350

HCl 1.180

Aqueous NaOH Solution 0.820

Toluene 0.240

1,2 Dichlorobenzene 2.290

Aluminium chloride 1.860

Chloro amine 1.500


Ethyl acetate 0.200


Methyl ethyl ketone 1.800

L(+) tartaric acid 0.640


66. Losartan Potassium Ortho tolyl benzonitrile 1.510

Triethyl amine HCl 2.180

Xylene 0.250

Toluene 0.370

Trityl chloride 2.380


Methanol 0.110

Sodium azide 1.270

Benzoyl peroxide 1.380

Chloroform 0.120

Dimethyl dibromo 0.910


Hyflow super cell 1.270

Caustic soda 0.290

TBAI (Catalyst) 0.020


Carbon 0.370

Acetic acid 0.110

Ethyl acetate 0.070


Acetonitrile 0.070

67. Lurasidone

hydrochloride

LNK- KSM-01 0.980

LNK- KSM-02 0.630

Sodium carbonate- 0.850

Toluene 0.130

LNK KSM-03 0.520

potassium carbonate 0.450

Xylene 0.080

Methanol 0.090

IPA HCl 0.820

68. Macitentan 5-(4-Bromophenyl)-4,6-dichloro

pyrimidine (KSM-02) 0.800

Potassium (N-Propyl sulfonyl) amide

(KSM-01) 1.160

N,N Dimethyl Formamide 4.180

Acetic Acid 0.920

Ethylene glycol 2.640

potassium tert-butoxide 1.240

acetic acid 0.860

Methanol 4.660

Sulfolane 1.040


Sodium hydride (55% in mineral oil) 0.420

2-Chloro-5-bromo pyrimidine (KSM-

03) 0.800

isopropyl alcohol 0.240

Toluene 0.070

ethyl acetate 0.180

Activated carbon 0.220

Celite 0.120

69. Meloxicam Inter-A3 1.110

Inter-A5 0.510

Mix - xylene 0.200

NaOH 0.150

Acetic Acid 0.870

MeOH 1.860

DMF 0.060

Toluene 0.160

Methanol 0.060

70. Mesalamine NaOH 1.060

2 chloro 5 nitro benzoic 1.050

HCl 4.500

5 Nitro Salicylic acid 0.300


Raney Nickel 0.150

Hydrazine hydrate 0.350

Sodium hydrosulphide 0.010



71. Metoprolol Succinate 4-(2-Methoxyethyl) phenol 0.650



Ethyl Acetate 0.160

Isopropyl Amine 1.050

IPA 0.100

Acetone 0.140

Succinic Acid 0.200

72. Midodrine

Hydrochloride

1,4 Dimethoxy benzene 1.330

chloroacetyl chloride 1.330

Aluminium chloride 2.990


Sodium azide 2.460



Acetone 0.120


Reducing agent 0.860



Tetra hydro furan 0.110

Toluene 0.150


Boc-NH glycine 1.930

Dehydrating agent 2.330

HCl 2.190

sodium bicarbonate 0.200

Ethyl acetate 0.140

Celite 0.660

73. Mirabegron (R )-2 Hydroxy-2-phenyl acetic acid 0.580

2-(4-nitrophenyl) ethane amine HCl 0.770


DMF 0.180

1-hydroxy benzotriazole (HoBt) 0.050

EDC. HCl 0.770

ethyl acetate 0.220

1 M HCl solution 1.890

20% K2CO3 solution 0.890

Toluene 0.130

1,3 dimethyl - imidazolidinone 3.650

THF 0.170

Methanol 0.460

1M Borane THF solution 1.840

HCl 0.930

30% K2CO3 Solution 0.520

Pd/c 0.120

DIPE 0.150

2-(2 aminothiazol-4-yl) acetic acid 0.470

NaOH solution 0.400

74. Nicorandil Methyl Nicotinate 1.000

Mono ethanol amine 0.530

Acetone 0.150

Nitric acid 3.000

caustic soda 0.860

HCl 0.530

Hyflow 0.100

Charcoal 0.240

MDC 0.080

75. Olmesartane 4-(1- hydroxy 1- methylethyl)- 2

propyl H-imidazole- 5 carboxylic acid 1.250

4-(chloromethyl)-5-methyl-2-oxo-1,3

dioxolane 1.870

ethyl acetate 0.120

K2CO3 0.850

DIPE 0.240

5-(4-(bromomethyl) [1,1-biphenyl]-2- 2.200


yl]-2-(triphenyl methyl)-2H-tetrazole

methanol 0.300

MDC 0.440

15% NaCl 2.370

IPA 0.380

30% HCl 0.260

THF 0.110

n-butanol 0.310

76. Omeprazole

Magnesium

Omeprazol API 0.950

NaOH 0.120

MgCl2 0.310

77. Pantoprazole

Sodium

KSM-14 0.660

NaOH 0.370

IPA 0.540

Sodium Hypochlorite 2.680

Acetone 1.290

78. Paroxetine

Hydrochloride

Triethyl Amine 0.090

Toluene 0.140

(-)-Alcohol 0.120

Methane Sulfonyl Chloride 0.080


Methanol 0.030

Sesamol 0.060

Dimethyle Sulfoxide 0.580

Phenoxy Chloroformate 0.080


Isopropanol 0.110



Acetone 3.030

79. Phenteramin Acetic acid 2.500

NaCN 1.750

Sulfuric acid 1.620

Dimethyl benzyl carbinol 1.000

HCl 1.000

MDC 0.150

FeSO4 Solution 0.010

Ethyl acetate 3.500


Dry HCl 2.200

80. Pramipexole Dihydro

Mono Hydrate

Trans-4-amino cyclo hexanol 0.490

Phthalic anhydride 0.690

p-Toluene sulfonic acid 0.010

Toluene 1.660

Ethyl acetate 1.640

Chromium trioxide.2H2O 0.390



Acetone 0.220

IPA 0.540

Celite 0.200


Ethanol 2.130

Bromine 0.950

Thio urea 0.600

Mono methyl amine(40% w/w) 2.080

L(+)-Tartaric acid 0.950


Potassium bicarbonate 0.770

n-Propyl Bromide 0.690




IPA-HCl (15%) 1.540

81. Pregabalin MDC 0.110

Isovaleraldehyde 0.410

Di methyl malonate 0.740

Morpholine 0.080

Acetic Acid 0.070


NaHCO3 Solution 1.240

Hyflow 0.240

Ethanol 1.000

NaCN 0.200

Hexane 0.110

Acetic acid 0.270

Dimethyl sulfonide 3.680

NaCl 0.380

Methyl tertiary butyl ether 0.310

MeOH 3.390

KOH 0.790

Raney Nickel 0.410

Acetic acid 0.840

Liq. NH3 0.310

IPA 0.690

L(+) mandelic acid 2.480

THF 0.280

82. Propefenone O-Hydroxy acetophenone 0.760

Benzaldehyde 2.140


Conc. HCl acid (30%) 0.870

Hexane 2.910

Palladium charcoal 0.110


Methanol 0.330

Acetone 0.580

Epichlorohydrine 1.690



Charcoal 0.030

Propyl amine 0.110

HCl 0.620

83. Polmacoxib 4(3-bromo-5,5-dimethyl-4-oxo-4,5-

dihydrofuran-2-

yl)benzenesulfonamide

0.600

3-fluorophenyl) boronic acid 0.300

Toluene 0.030

Ethanol 0.040

Palladium tetrakis 0.400

84. Quetiapine

Hemifumerate

Dibenzo(B,F)[1,4] 1.100

POCl2 0.900

DMA 0.410

Toluene 0.300

Hexane 0.240

Piperazine 1.300

Xylene 0.070

30% HCl 1.150

Ethyl Acetate 0.250

25% NaOH Solution 0.370

2-Choro ethoxy ethanol 0.500

Na2CO3 1.500

Ethanol 0.160

DMF 0.130

Flmeric Acid 0.270

THF 5.000

85. Ranolazine Chloro Acetyl Chloride 0.110

2,6 Xylidine 0.100

sodium Bicarbonate 0.110

Acetone 0.060

Piperazine 2.140

methanol 0.150

Toluene 0.350

Hexane 0.120

HCl 0.370

Iso propyl alcohol 0.180


caustic soda 0.330

Guiacol 0.800

Carbon + Celite 0.120

86. Rasagiline Beyslate 1-Indanone 0.940


Hydroxylamine Hydrochloride 0.540

Methanol 0.920


Ammonia (gas) 0.570

Raney Nickel 0.250

Hyflow 0.180


5% Hydrochloric acid 0.830

40% Sodium Hydroxide 1.120


87. Risperidone Pyrimidine HCl 1.310

Benzisoxazole 1.090


Potassium Iodide 0.160

Toluene 0.070

Acetone 2.010

Methanol 0.060

Celite 0.100


88. Rivastigmine (S)-3-(1-(dimethyl

amino)ethyl)phenol 1.360

S-(+) Camphor sulphonic acid 1.900

Methanol 0.220

Ethyl acetate 0.230

sodium carbonate solution 0.020

(KSM – 02) 0.640

sodium hydride 0.570

toluene 0.960

89. Roflumilast 3-(cyclopropylmethoxy)-4-(difluoro

methoxy) benzaldehyde 1.030

Sodium Chloride (80%) 0.480

Acetic Acid 0.260

Sulphamic Acid 0.410


Toluene 0.130

Hexane 0.140

4-amino 3,5-dichloro pyridine 0.600

Sodium hydride (60%) 5.680


10% HCl 3.140

MIDC 4.200

Saturated NaHCO3 Solution 1.500

MgSO4 (anhydrous) 0.100

IPA 0.130

90. Rosuvastatin NRSC DMP Ester 1.170


Calcium RO Aldehyde 0.710

Potassium tert Butoxide 0.270

THF 0.070

Acetic Acid 0.070


Ethyl acetate 0.090

Charcoal 0.110

Hyflow 0.500

Methanol 0.490

Hexane 0.140

Toluene 0.110

Acetonitrile 0.040

HF (48% Aq.) 0.100

DIPE 0.060

NaHCO3 0.330

NaCl 0.780

THF 0.220

MlOH 0.980

DEMBO 0.160

NaBH4 0.050

Cyclohexane 0.240

NaOH 0.250


t-Butyl Amine 0.500

2N HCl 1.700

MDC 0.100

CaCl2 0.020

BHT 0.020

91. Rosuvastatin

Ethanol Amine

Rosuvastatin condensed (RO-118) 1.000

HCl acid 0.560

Methanol 0.170

NaOH 0.200

Charcoal 0.500

Hyflow 0.500

ethyl acetate 0.510

Toluene 0.400

Sodium sulphate 0.500

Mono ethanol 0.120

92. Sacubitril Valsartan

Trisodium

(2R,4S) PA 1.200

HCl 2.000


Absolute Ethanol 4.070


Toluene 0.160

DIPE 0.390

Acetonitrile 0.110


succinic anhydride 0.300

DMAP 0.040

TEA 0.730

DCM 1.430

NaOH 0.092

Methanol 0.130

MeOH 0.240

Valsartan 0.480

EtOAc 0.250

cyclohexane 1.450

93. Saroglitazar Hydroxy Compound 0.570

Mesylate Compound 0.850


Cyclohexane 0.120


18-Crown-6-ether 0.020


Alkaline Charcoal 0.050



Ethanol 0.090

MTBE 0.190

HCl 0.310

Celite 0.050



n-Heptane 0.170

n-Butyl acetate 0.060

Magnesium acetate tetrahydrate 0.510

Magnesium sulfate (anhydrous) 0.200


94. Saxagliptin DIPEA 0.960

Acetonitrile 1.600

ethyl acetate 1.230

KSM-1 0.790

KSM-2 1.100

HOBt 0.500

EDC 0.710

2N HCl 0.770

IPA 1.740

Brine 0.950

KHCO3 1.300

Methanol 0.100

Ethyl nicotinate 0.950

TFAA 0.420

tetra methyl ethylene amide 0.170


seeding 0.010

MDC 0.180

NaOH 0.420

K2CO3 1.880

NaCl 0.760

EtoAc 0.180

95. Sertraline

Hydrochloride

Tetralone 1.000

Methanol 0.440

Mono methyl mine 0.500

Toluene sulfonic acid 0.020

Methylene dichloride 0.420


Acetic acid 0.150

Caustic soda flakes 0.510

Isopropanol Hydrochloride 1.690

Ethanol 4.520

D (-) mandelic acid 0.760

Hyflow super cell bed 0.790

Ethyl acetate 0.160

96. Sildenafil Citrate 1 - Methyl-3n- propyl pyrazole 5-

carboxylic acid 1.030

Oleum (65%) 0.750

nitric acid 0.400


Acetone 4.510

Aq. NH3 solution (20% w/w) 1.090

stannous chloride 1.350

ethanol 2.360

NaoH solution (20%) 1.020

MDC 0.970

MgSO4 1.680

DIPE 0.300

2-ethoxy benzoyl Chloride 1.190


Methanol 0.110

HCl 1.320

ethyl acetate 0.710

hexane 0.280

NaOH solution (40%) 0.290

H2O2 1.460

Sat. NaHCO3 Solution 1.380

Sat. NaCl Solution 1.950

chlorosulfonic acid 0.310

Na2SO4 solution 0.400

N-Methyl piperazine 0.270

dimethyl formamide 0.100


97. Silidosin Silidosin Amine 2.250

Silodosin Bromo compound 2.050

Na2CO3 0.940

Ethanol 0.330

t-Dibutyl dicarbonate 1.250

MDC 0.520

5N NaOH 0.250

30% H2O2 0.120

DMSO 0.110

3 Bromo propanol 0.750

98. Sitagliptine

phosphate

Anhydrous/

Besylate

(3R)-3-[1,1-dimethyl

ethoxycarbonyl)amino-4-(2,4,5-

trifluro phenyl) butanoic acid

1.720

3-(trifluromethyl)-5,6,7,8-tetrahydro-

1,2,4-triazole [4,3 -alpha]pyrazine 1.350

EDC 1.180

HOBT 0.860


Methanolic HCl 1.250

99. Sparfloxacin Spar acid 1.000

Piperazine comp. 0.500


Acetonitrile 0.100

Con. HCl 0.040



Celite 0.120

100. Tamsulosin HCl R-(-)- Tamsulosin Amine 1.210

Tamsulosin Bromo compound 1.210

KHCO3 0.740

IPA 0.210

IPA-HCl 5.130

Acetonitrile 0.180

NaOH 1.880

Celite 0.180

Charcoal 0.060

Conc. HCl 1.640

Methanol 0.150

Celite 0.160

101. Tebipenem Pivoxil Compound 25 0.570

Acetone 0.150

Chloroform 0.200

Diiso propyl ethyl amine 0.110

4-Nitrobenzyl(1R,5S,6S)-2-(diphenyl

phosphoryloxy)-6-[(R)-1-

hydroxyethyl]-1-methylcarbapen-2-

1.800


em-3-carboxylate

Ethyl acetate 0.420

Saturated Sodium chloride solution 0.200


Phosphate buffer 1.600

Zinc powder 0.400


Pivalic acid iodomethyl ester1 0.670


102. Telapvir DMF 0.350

Pyrazine carboxylic acid 0.390

CDI 0.510

KSM-02 1.230


MDC 1.110

HCl 1.850

Toluene 0.420

EDC HCl 0.720

HOBt hydrate 0.260

Sodium bromide (15%) 0.620

sodium bicarbonate 2.320

TEMPO 0.010

sodium hypochlorite 3.000

ethyl acetate 0.200

103. Telmisartan SM1 0.740

SM2 0.730

Potassium butoxide 0.230

Ethyl acetate 0.230

DMSO 0.100

104. Tenegliptin Boc Piperazine 0.800

Diketene 0.320

DMF 0.240

ethyl acetate 0.690

Brine 2.400

ethanol 0.120

phenyl hydrazine 2.880

MSA 0.370

Pyridine 1.410

Phosphorus oxychloride 0.530

HCl 2.040

Na2CO3 2.680


trifluroacetic acid 0.850

Diethyl ether 1.600

chloroform 1.600

Thiazolidine 0.510


DMF 0.240

HOBT 2.960

EDC.HCl 1.120

Triethylamine 1.530

sulfur trioxide pyridine complex 1.740

Dimethyl sulfoxide 1.060

KSM-1 1.000

KSM-2 1.000

acetic acid 0.400

sodium triacetoxy borohydride 0.980

1,2 dichloro ethane 0.940

Methanol 0.150

chloroform 1.500

1,4 dioxane 1.000

105. Amlodipine Besylate Phthalic Anhydride 0.780

Mono Ethanol Amine 0.320

Xylene 0.210

ethyl 4-chloro acetoacetate 0.080

Toluene 0.050

acetic acid 0.290

sodium hydride 0.040

methanol 0.040

Morpholine 0.040

O-chloro Benzaldehyde 0.320

Methanol 0.270

3-Methyl Amino Crotonate 1.000

Mono methyl amine 4.000

Benzene sulphonic acid 0.660


Ethyl acetate 0.280

106. Etodolac Ethyl tryptophol 0.620


Methyl 3-oxopentanoate 0.430

Boron trifluoride etherate 0.030


10 % Brine solution 1.870

Methanol 0.080

Isopropanol 0.100


Cyclohexane 0.270


107. Tirofiban HCl L-Tyrosin 0.800


Methanol 1.330


ACN 0.110


Pyridine 1.470

1-butane sulfonyl chloride 1.380

MDC 0.200

Potassium bi carbonate 0.940

Hyflow 0.230

Carbon 0.230

Toluene 1.470

u-Picoline 0.840

n-Butyl lithium 0.930

THF 1.170

Bromo chloro Propane 1.490

Ethyl acetate 0.290

Brine Solution 0.500


IPA 0.080

Oxalic Acid 1.520

DMSO 5.730

KOH 0.740

Int. A 1.000

KI 0.010

NaOH Solution 3.050

Pa/C 0.500

Acetic Acid 1.220

H2 0.540

HCl 0.420

108. Toficitinab Citrate Acetone 2.080

PTSCI 0.650

TFA-KSM-1 0.470

K2CO3 1.470

TFA-KSM-2 1.000

NaOH 2.960

HCl 2.530

Methanol 0.580

Pd/c 0.030

MDC 3.130

Cyclohexane 0.080

THF 1.250

DBU 0.100

ECA 0.560

MeOH 0.980

citric acid 0.600

ethanol 0.100


109. Tolvaptan 2-methyl-4-nitro benzoic acid 1.960


advanced intermediate (TIK 06) 1.780


N,N-Dimethyl acetamide 5.280

Toluene 0.400

Stannous chloride dehydrate 1.810

HCl 2.500

Methanol 0.660

Caustic solution 1.760

MDC 0.130

Ethyl acetate 0.200

O-toluic acid 0.820

Potasium bicarbonate 1.140

Sodiium borohydride 0.100

Acetic acid 0.710


110. Topiramate Sulfuryl Chloride 0.510

o-xylene 0.060

Diacetone Fructose 0.680

Pyridine 0.170

ammonia gas 0.070

Citric acid 1.710

1,4 Dioxane 2.560

n-Hexane 0.040

Ethanol 0.300

charcoal 0.010

Celite 0.010

111 Tramadol HCl Toluene 0.260



THF 0.120

Mg-T 0.140

m-Bromo anisole 1.090

Iodine 0.010

Ammonium Chloride 1.080

Salicylic Acid 0.130

IPA 0.080

Acetone 0.100

Hyflow 0.110

Charcoal 0.050

IPA. HCl 0.040

112 UDCA (India

Market)

7-KLCA 1.000

Raney Nickel 0.500


isopropyl alcohol 0.220

HCl 0.550

triethyl amine 0.350

2-Butanone 2.550

HCl 0.580


113 Valdecoxib VLD-II 0.830

N-Butyl lithium 1.050


Diisopropyl amine 1.160

Tetra hydro furan 0.150


Ethyl acetate 0.080

Toluene 0.170

Chloro sulfonic acid 2.410

Liquid NH3 2.160


SDS 0.070

Celite 0.100


114 Valsartan 4'-Bromo methyl 0.890

(L) Valine methyl ester HCl 0.570

K2CO3 0.680

DMF 0.100

Toluene 0.370

15% Brine 2.500

Valeroyl chloride 0.500

TEA 0.680

DCM 0.250

HCl 2.540

8% NaHCO3 solution 3.220

Na2SO4 solution 0.160

Tributyl tinchloride 0.520

Sodium azide 0.530

Xylene 0.220

Celite 0.840


NaNO2 1.200

Na2CO3 solution 0.350

NaOH 0.680

115. Venlafaxine HCl n-heptane 0.100

NaOH 0.670

t-BuOH 0.440

PMPA 0.800

Toluene 0.180

Cyclohexane 0.590

Acetic Acid 0.960

MDC 0.150

MeOH 0.180

Raney Nickel 0.650

Hyflow 0.860

HCHO 1.130


HCOOH 1.070

HCl solution 0.670

CHCl3 1.270

NaOH 0.790

CHCl3 0.190

MEK 0.190

Charcoal 0.100

IPA HCl 0.860

IPA 0.220

116. Vilazodone HCl VLA-KSM01 0.750

VLA-KSM02 0.750

Diso propyl ethyl amine 0.600

DMSO 7.500

Acetone 0.150


117. Vildagliptin Prolinamide 1.480

Chloro acetyl chloride 1.350

THF 0.410


TFAA 1.200

Ethyl acetate 0.160

Amino adamantanol 0.010

K2CO3 0.380

MTBE 0.160

118. Vortioxetine

Hydrobromide

2,4-Dimethyl thiophenol 0.600

1-Chloro-2-nitrobenzene 0.720

DMF 0.150

Methanol 0.450

HH 0.860

Raney Ni 0.180

Ethyl acetate 0.710

Hyflow super cell 0.180

n-Butanol 0.090

K2CO3 1.780

BCA 0.660

KI 0.020

NH4OH 1.470

NaCl 0.430

Aqueous HBr 1.620

EtOAc 0.120

MDC 0.120

HPMC 0.270

119. Warfarin Sodium

Clathrate

4-Hydroxy coumarin 0.650

Benzylidiene acetone 0.770

TEBAC 0.080

Toluene 0.030


Isopropanol 0.680

NaOH 0.180

Charcoal 0.020

Celite 0.100

120. Ziprasidone HCl 6-Chloro-5 -(2-Chloroethyl) Oxindole 0.820

3-(1-Piperazinyl)-1,2-benzisothiazole 1.090


Acetic acid 2.360

Iso propanol 0.180

Ziprasidone Base Crude 1.190


Dimethoxide Sulfoxide 1.540

Celite 0.130


HCl 0.500

Iso propyl Alcohol 0.790

121. Azathioprine 6MP 0.060

CMNI 0.060

NH3 solution 0.300

Acetone 0.030

HCl 0.060

122. Febuxosate 4-Hydroxy 3-nitrobenzaldehyde 1.140

Hydroxyl amine 0.570

sodium formate 0.820

Formic acid 2.980

Thioacetamide 1.070

DMF 0.190

2N NaOH 1.530

Ethanol 0.100

Ethay 2-chloro acetoacetate 0.790

DMF 0.270

K2CO3 2.130

Isobutyl bromide 1.840

Ethyl acetate 0.300

NaCl solution 1.440

Pd/c 0.230

Methanol 0.220

Hyflow 0.040

NaNO2 0.530

HCl 1.500

CuCN 1.730

KCN 1.110

123. Lacosamide D-Sarine 1.180

Acetonitrile 0.250


BOC-Anhydried 1.950


HCl 3.810

Ethyl acetate 1.920

N-Hexane 0.100

Toluene 0.350

TBAB 0.080

Aqueous NaOH 3.480

Dimethyl sulfate 2.890


Citric acid 1.810

N-Methyl morpholine 0.540

Isobutyl chloroformate 0.730

Benzyl amine 0.600

NaHCO3 solution 0.920


Diso propyl ether 0.270

124. Refaximin RFM 1.100

Ethanol 0.220

RFM Z 0.010

125. Tolperisone Anhy.AlCl3 0.110

Toluene 2.370

Propionic anhydride 0.050

HCl 2.650

NaHCO3 1.150

IPA HCl 0.080

Piperidine HCl 1.000

Parafomaldehyde 0.190

n-Butanol 0.610

Ethyl Acetate 0.150

NaOH 0.270

Hyflow 0.060

126. Udenafil DCM 1.080

KSM-01 0.830

Chlorosulphonic acid 1.330

sodium sulfate 0.830

Sodium bicarbonate solution 1.250

Acetone 0.330

KSM-02 1.660

Methanol 1.000


5. MANUFACTURING PROCESS

Please refer Annexure-II of Form No. 1 for process description, chemical reaction &

mass balance of all products.

6. DETAILS OF MANPOWER

Total manpower required at all level of plant will be 120 nos.

7. WATER BALANCE

Water balance diagram is given below:


Water Balance Diagram

Water consumption (KLD):1395 KLD

(Fresh: 440 KLD + Recycle: 955* KLD)

Domestic

100

Water treatment

595

595

Water treatment

560 Washing

50 Greenbelt

90

STP

90* Process

470

595

Utilities

450

595

Process

450

595

Scrubber

10

595

Lab

10

595

High COD

175

595

Low COD

310

595

ETP-1

150+310+10+10=480

595

Water retained

RM 35

1

595

Boiler

150

595

Cooling

300

595

ETP-2

15+100+50=165

595

15

595

100

595 50

595

Reject

125

1

595

Reject

110

1

595

RO

400

595

Permeate

320*

595

MEE-2

180

595

Condensate

165*

595

310

595

MEE-1

166

595

Stripping

175

595

Condensate

150

595

ATFD

31

595

RO

480

595

Permeate

380*

595

Reject

100

595

Reject

80

595

Salt 12.0 ton

595

Loss 19

595

Equalization

sump

400

595

Residue

9

595


8. SOURCE OF POLLUTION:

Details of Air Pollution

The main source of emission will be of process emission. Proper stack height and APC

measure will be provided in order to achieve norms prescribed by statutory authority. The

details of stacks are given below:

Sr.

No.

Stack

attached to

Stack

Height

(m)

Fuel Type Fuel

consumption

rate

Stack

Dia.

APCM Probable

pollutants

Flue gas Emission/stack

1. Boiler-1

5 TPH

30 Coal/ white

coal/lignite/

imported coal

20 TPD 0.6 Cyclone

& Bag

Filter

PM <150

mg/NM3

SO2 <100

ppm

NOX <50

ppm

2. Boiler-2

6 TPH

30 Coal/ white

coal/lignite/

imported coal

25 TPD 0.6 Cyclone

& Bag

Filter

3. Boiler-3

12 TPH

30 Coal/ white

coal/lignite/

imported coal

48 TPD 0.6 Cyclone

& Bag

Filter

4. D. G. Set

500 kVA

11 HSD 125 LT/Hr 0.3 --

5. D. G. Set

750 kVA

11 HSD 175 LT/Hr 0.3 --

6. D. G. Set

1000 kVA

(2 nos)

21(Comm

on stack)

HSD 250 LT/Hr

each

0.45 --

Process gas Emission/stack

1 Process

vent-1

21 -- -- 0.3 Water &

Alkali

Scrubber

SO2<45

mg/Nm3

Cl2< 9

mg/Nm3

2 Process

vent-2

21 -- -- 0.3 Water &

Alkali

Scrubber

HCl< 20

mg/Nm3

SO2<45

mg/Nm3

3 Process

vent-3

21 -- -- 0.3 Water &

Alkali

Scrubber

HCl< 20

mg/Nm3

SO2<45

mg/Nm3

4 Process

vent-4

21 -- -- 0.3 Water &

Alkali

Scrubber

HCl< 20

mg/Nm3

SO2<45

mg/Nm3

5 Process

vent-5 21 -- -- 0.3

Water &

Alkali

Scrubber

HCl< 20

mg/Nm3

SO2<45

mg/Nm3

6. Process

vent-6 21 -- -- 0.3

Water &

Alkali

Scrubber

HCl< 20

mg/Nm3

SO2<45

mg/Nm3

7. Process

vent-7 21 -- -- 0.3

Water &

Alkali

Scrubber

HCl< 20

mg/Nm3

SO2<45

mg/Nm3


8. Process

vent-8 21 -- -- 0.3

Water &

Alkali

Scrubber

HCl< 20

mg/Nm3

SO2<45

mg/Nm3

9. Vent of Spin

Flash Dryer

(8 Sets) 11 -- -- 0.3

In built

Cyclone

and Bag

filter

PM<150

mg/Nm3

Source of wastewater

Source of wastewater generation is from process, scrubber, boiler, lab, utility and

washing. Effluent from process will be segregated into 2 streams - high COD &

Low COD. High COD stream will be passed through solvent stripper followed to

MEE 1. Condensate of MEE 1 will be taken on ETP-1 along with stream of low COD,

scrubber and lab will be treated in ETP-1 followed to RO. RO permeate will be

reused and reject will be taken to MEE 2.

Effluent from water treatment, utility and washing will be treated in ETP-2 followed

to RO and then MEE. RO reject will be followed to MEE. ML of MEE-1 & MEE-2 will

be taken to ATFD. Salt from ATFD will be disposed to TSDF site. RO permeate and

MEE condensate will be reused. Domestic wastewater will be treated in in-house

STP and reused for greenbelt.

Source and disposal of Hazardous wastes

There will be 10 types of hazardous waste generation i.e. ETP sludge, MEE salt,

process residue, spent carbon, spent catalyst, spent solvent, distillation residue,

off specification product, date expired product used oil, discarded

containers/liners. Detail of hazardous waste is given below:

Sr.

No.

Type of

Waste

Category

of Waste

Quantity Disposal facility

1. ETP Sludge

+

MEE salt

35.3 200

Mt/Month

250

Mt/Month

Collection, Storage, Transportation &

Disposal at TSDF site.

2. Process

residue/

process sludge

(organic &

Inorganic)

28.1 75

Mt/Month

Collection, Storage, Transportation

and disposal by selling to cement

manufactures for co-processing or

Incinerated at CHWIF.

3. Spent carbon 28.3 75

Mt/Month





4. Spent Catalyst 28.2 0.5

Mt/Month


and by back to supplier for

reactivation or reprocess.


5. Spent solvent 28.6 2500

Mt/Month


and distillation in-house for recovery

of solvent or send it to authorized

distillation facility approved by SPCB.

6. Distillation

Residue

36.1 640

Mt/Month





7. Off

specification

Product

28.4 What so

ever

generated





8. Date expire

Product

28.5 What so

ever

generated





9. Used oil 5.1 30

Kl/Year


and sale to Registered recycler

10. Discarded

Drums

& containers/

Liners

33.1 25000

Nos./Month

15

Mt/Month

Collection, Storage, Transportation,

decontamination and sale to actual

users or vendors.

FUNDS FOR POLLUTION CONTORL MEASURES

The management is quite conscious of its responsibility for maintaining clear

environment adequate funds can be provided for the pollution control measures as

financing part of overall project.

Necessary provision for Environmental management system is in practice.

9. MONITORING FACILITES

Air sampling will be done by outside agency and will be part of practice in future

proposed projects.

10. CONCLUSIONS AND RECOMMENDATIONS

On the basis of information presented in the pre-feasibility report on pollution

control measures and after its implementation, there will be no discharge of

effluent and air emission from the plant beyond the norms specified by the Board

as per the provisions of Air (Prevention and Control of Pollution) Act, 1981 and

Water (Prevention and Control of Pollution) Act, 1974.

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