Pre-Feasibility Report M/s. Satellite Pharmaceuticals Pvt. Ltd. Plot No.: B-40, MIDC Paithan, Taluka-Paithan, District-Aurangabad, Maharashtra
April 2017
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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Table of Contents
1. Executive Summary .......................................................................................................... 3
2. Introduction of the Project ............................................................................................... 5
I. Identification of project and project proponent: ............................................................... 5
II. Nature of the project. .................................................................................................... 5
III. Need of the Project and its importance to the country and or region .................................. 5
IV. Demand-Supply Gap ...................................................................................................... 6
V. Imports vs. Indigenous Production .................................................................................. 7
VI. Export Possibility ........................................................................................................... 7
VII. Employment Generation (Direct & Indirect) due to the project ........................................... 7
3. Project Description .......................................................................................................... 8
I. Type of Project including interlinked and interdependent projects ...................................... 8
II. Location of Project ........................................................................................................ 8
III. Details of Alternate Site ............................................................................................... 11
IV. Size or Magnitude of operation ..................................................................................... 11
V. Project Description with process details ......................................................................... 12
VI. Raw Material Required ................................................................................................ 35
VII. List of Plant Machineries .............................................................................................. 35
VIII. Resource optimization/recycling and reuse .................................................................... 36
IX. Auxiliary Requirement ................................................................................................. 36
X. Waste Generation & Management ................................................................................ 36
XI. Schematic representations of the feasibility drawing which give information of EIA purpose.
37
4. Site Analysis .................................................................................................................. 38
I. Connectivity ............................................................................................................... 38
II. Land Form, Land Use & Land ownership ......................................................................... 38
III. Topography ................................................................................................................ 38
IV. Existing Land use pattern ............................................................................................. 38
V. Existing Infrastructure .................................................................................................. 38
VI. Soil Classification ......................................................................................................... 39
VII. Climate data from secondary sources ............................................................................ 39
5. PLANNING BRIEF ............................................................................................................ 41
I. Planning Concept ........................................................................................................ 41
II. Population Projection .................................................................................................. 41
III. Land use Planning........................................................................................................ 41
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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IV. Assessment of Infrastructure Demand ........................................................................... 41
V. Amenities/Facilities ..................................................................................................... 41
6. Proposed Infrastructure ................................................................................................. 42
I. Industrial Area ............................................................................................................ 42
II. Residential Area .......................................................................................................... 42
III. Green Belt .................................................................................................................. 42
IV. Social Infrastructure .................................................................................................... 42
V. Connectivity ............................................................................................................... 42
VI. Drinking Water ............................................................................................................ 42
VII. Sewerage System ........................................................................................................ 42
VIII. Industrial Waste Management ...................................................................................... 42
IX. Solid Waste Management ............................................................................................ 42
X. Power Requirement ..................................................................................................... 43
7. Rehabilitation and Resettlement (R & R) Plan ................................................................... 43
8. Project Schedule & Cost Estimates .................................................................................. 43
I. Likely date to start of Construction & likely date of completion ........................................ 43
II. Estimated Project Cost ................................................................................................. 43
9. Analysis of Proposal ....................................................................................................... 43
I. Financial & Social Benefits ............................................................................................ 43
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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1. Executive Summary
M/s. Satellite Pharmaceuticals Pvt. Ltd. existing synthetic organic chemical
manufacturing industry located at Plot No. B-40, MIDC Paithan, District-Aurangabad,
Maharashtra currently involving in chemical manufacturing Sodium Chloride,
Ammonium Chloride & Potassium Chloride which are used in cough formulation as
expectorant . Now, said industry propose for expansion with respect to
manufacturing of 15 type of intermediates chemicals which will be useful in
pharmaceutical industry. M/s. Satellite Pharmaceuticals Pvt. Ltd. having total plot area
6840 Sq.M. & total built up Area 1570.39 Sq.M. vide MIDC sanction letter no.
DB/2231/ of 2009 dated 24/12/2009. For expansion purpose no any additional
construction activity will be involved.
In existing plant, three types chemicals viz. Ammonium Chloride, Potassium Chloride
& Sodium Chloride are going to manufacturing with valid consent from Maharashtra
Pollution Control Board (MPCB) vide letter no. MPCB-16/161000823
MPCB/ROA/ABD/E-25/98/O/C-749/633/2016 dated 24/10/2016 & further
amendment vide letter no. MPCB/ROA/Amend/196/2017 dated 06/03/2017. These
products are used in preparation of formulations having expectorant action.
For proposed expansion activity involves manufacturing of 15 types of intermediates
chemicals. As per the EIA Notification 2006 & amendments thereof, for manufacturing
of Bulk Drugs & Intermediates chemicals requires Environment Clearance under the
category 5(f).
Table No. 1 : Production Details
Sr.No. Name of Chemical Quantity
EXISTING PRODUCTION DETAILS
1. Ammonium Chloride 11 MT/M
2. Sodium Chloride 11 MT/M
3. Potassium Chloride 11 MT/M
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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PROPOSED PRODUCTION DETAILS
1. Benzhydrol 250 MT/Yr
2. 2-(2 bromoethyl) benzaldeyde 3 MT/Yr
3. Cinnamyl alcohol 56 MT/Yr
4. Diethyl amine salicylate 60 MT/Yr
5. Ethyl triphenyl phosphonium bromide 18 MT/Yr
6. Isosorbide 36 MT/Yr
7. Bromo methyl cyano biphenyl 17 MT/Yr
8. Isosorbide-2-acetate 20 MT/Yr
9. Tetrabutyl ammonium bromide 117 MT/Yr
10. Isatoic anhydride 58 MT/Yr
11. Tri-o-tolyl phosphine 11 MT/Yr
12. Meta chloro propiophenone 25 MT/Yr
13. 3-Chloro-4-N-morpholino 1,2,5
thiadiazole
4 MT/Yr
14. 4-methoxy propiophenone 99 MT/Yr
15. Anethole 58 MT/Yr
With reference to Environment & Social safety point of view, proposed manufacturing
activity involves manufacturing of organic chemicals which will be used as
intermediate in active bulk drug manufacturing industry. Project site is located within
Maharashtra Industrial Development Corporation (MIDC) Paithan, thus industrial
activity is permitted. Following studies are recommended Environment Impact
Assessment (EIA), Environment Management Plan (EMP), Disaster Management Plan
(DMP), Risk & Hazards study, Solid waste management, Hazardous waste storage,
disposal will be studied & followed.
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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2. Introduction of the Project
I. Identification of project and project proponent:
M/s. Satellite Pharmaceuticals Pvt. Ltd. an existing synthetic organic chemical industry
located at Plot No. B-40, MIDC Paithan, District-Aurangabad, Maharashtra. Industry is
involving chemical manufacturing activity without drug manufacturing. Now, said
industry propose for expansion with respect to manufacturing of 15 type of Bulk Drugs
Intermediates which will be useful in pharmaceutical industry. They are used as an
intermediate of API belonging to antihistaminic, antidepressants , antihypertensive
and CNS stimulant.
Project proponent is Dr. Kedar Sinari, having M.Pharm and Ph. D (Tech) degree from
the prestigious ICT, Mumbai. He is the technical director of this company and has over
13 years experience working in pharma companies in India and abroad.
II. Nature of the project.
Proposed expansion activity involves manufacturing of 15 types of intermediate bulk
drugs chemicals. Manufacturing process involves series of chemical reactions from the
raw material to get final products. These final products will be useful in the bulk drug
pharmaceutical industry as a starting material to manufacture API (Active
Pharaceutical Ingredient).
III. Need of the Project and its importance to the country and or region
Now a day’s rate of human health diseases are increasing rapidly, medical treatment
with the help of drugs/medicines is a common practices in which, medicines/drugs
plays the important role in recover the health & control the diseases. Pharmaceuticals
industries required raw material in the form of synthetic chemicals, bulk drugs,
intermediates to prepare final products as a medicine. Bulk drugs interemdiates are
the active raw materials used in drug that are useful as therapeutic agents. Therefore,
proposed manufacturing of various Bulk Drugs & Intermediates has importance.
Many pharma companies enjoy success largely because their major operations are
based in Maharashtra. The government support received by the industry has been
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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substantial and the presence of a pragmatic and stable state government has been
one of the main reasons the state has managed to remain a principal destination for
all pharma companies whether Indian or MNC. Maharashtra has been a hub for the
pharma industry, both in terms of manufacturing as well as supply of materials.
Aurangabad industrial belt occupies 40% of chemical producing industries for pharma
and other industries. In view of future market demand it is best opportunity to set up
a business in Aurangabad which may lead to employment generation to local youth
and economical upliftment of Paithan region.
IV. Demand-Supply Gap
The Indian pharmaceutical industry is the world's second-largest by volume and is
likely to lead the manufacturing sector of India. Several Government and private
sector projects with huge amount of investments have been initiated but could not
attend the speed of development for the need of good quality material. Over the last
decade, there has been a sizeable growth in Pharmaceutical sector both in small,
medium and large scale units. This has given rise to many small and medium scale
units to manufacture pharmaceutical intermediate. The ever growing requirements of
India, due to higher population and various diseases indicated the need for the growth
of this industry. Thus there is a gap in demand and supply. Our efforts of generating
products, by-products, downstream products and recycling - reprocessing are indeed
needed. With multinational pharmaceutical companies enhancing their presence in
India, the long-term prospects of the pharmaceutical industry seem fairly bright.
Indian agro sector demand is increasing to improve productivity and to deal with
attack of various types of pests etc. The intermediates proposed will substitute
imports.
The food industry demand for preservative is increasing as multinational companies
are shifting manufacturing base in India. But the impact of some factors on the
industry's growth remains to be seen.
The fate of industrialization depends on the proper and effective conjugation of large
and medium/small scale industries each supporting each other in their requirement
to bridge the gap between demand and supply. In order to be competitive in the global
market this synergy between large & medium/small scale industries is a prerogative.
Therefore considering the above, large companies do require the help of small units
to support them by giving them quality products at lesser price.
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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V. Imports vs. Indigenous Production
Today’s Indian market going to be export intermediate chemicals for active
pharmaceutical industries.
VI. Export Possibility
Proposed industry is small scale industry so whatever products will produce it will
sell to local market only.
VII. Employment Generation (Direct & Indirect) due to the project
There will be no employment generation due to proposed industrial expansion.
Industry is being operated since 10 years and existing manpower will be efficient for
proposed product change.
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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3. Project Description
I. Type of Project including interlinked and interdependent projects
M/s. Satellite Pharmaceuticals Pvt. Ltd., is proposing for expansion with respect to
manufacturing of 15 type of intermediate synthetic organic chemicals. Does not
interlink with any project.
II. Location of Project
M/s. Satellite Pharmaceuticals Pvt. Ltd. ia an existing synthetic organic industry
located at Plot No. B-40, MIDC Paithan, District-Aurangabad, Maharashtra. Location
Map of the Project site is shown in Figure No. 1. & 2 . Project site is located 36 km at
South direction from Aurangabad city & 7 km at North direction from Paithan town.
Geographical location of industry is 19°32'35.08"N, 75°23'14.30"E with elevation of
470 m from mean sea level. Project site is spread in to 6840 Sq. M area within MIDC –
Paithan. Project site marked on Paithan MIDC layout plan is shown in Figure No.3. For
expansion purpose no additional plot or construction activity will be required.
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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M/s. Satellite Pharmaceuticals Pvt. Ltd.
at Plot No. B-40, MIDC Paithan, District-
Aurangabad, Maharashtra
Figure No. 1 : Location of Project Site
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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Figure No. 2 : Google Imagery of Project Site
Figure No. 3 : Paithan MIDC Layout Plan
Latitude : 19°32'35.62"N
Longitude: 75°23'12.11"E
Latitude : 19°32'33.85"N
Longitude: 75°23'12.48"E
Latitude : 19°32'36.39"N
Longitude: 75°23'16.10"E
Latitude : 19°32'34.56"N
Longitude: 75°23'16.48"E
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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III. Details of Alternate Site
It is the expansion of existing industry though alternate site not examined or
considered.
IV. Size or Magnitude of operation
Size & Magnitude of operation is presented below table
Table No. 2: Production Details
Sr.No. Name of Chemical Quantity
EXISTING PRODUCTION DETAILS
1. Ammonium Chloride 11 MT/M
2. Sodium Chloride 11 MT/M
3. Potassium Chloride 11 MT/M
PROPOSED PRODUCTION DETAILS
1. Benzhydrol 250 MT/Yr
2. 2-(2 bromoethyl) benzaldeyde 3 MT/Yr
3. Cinnamyl alcohol 56 MT/Yr
4. Diethyl amine salicylate 60 MT/Yr
5. Ethyl triphenyl phosphonium bromide 18 MT/Yr
6. Isosorbide 36 MT/Yr
7. Bromo methyl cyano biphenyl 17 MT/Yr
8. Isosorbide-2-acetate 20 MT/Yr
9. Tetrabutyl ammonium bromide 117 MT/Yr
10. Isatoic anhydride 58 MT/Yr
11. Tri-o-tolyl phosphine 11 MT/Yr
1. Meta chloro propiophenone 25 MT/Yr
2. 3-Chloro-4-N-morpholino 1,2,5 thiadiazole 4 MT/Yr
3. 4-methoxy propiophenone 99 MT/Yr
4. Anethole 58 MT/Yr
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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V. Project Description with process details
I. BENZHYDROL
Chemical Reaction :
O
H2/Ni/NaOH
OH
C13H12OExact Mass: 184.09Mol. Wt.: 184.23
C13H10OExact Mass: 182.07Mol. Wt.: 182.22
Benzophenone Benzhydrol
CH3OH,
CH3COOH
Product: Benzhydrol( CAS NO : 91-01-0)
Process description:
Step one: Benzophenone is dissolved in calculated amount of methanol at room
temperature. To this, sodium hydroxide solution is added followed by Raney nickel catalyst.
Then hydrogen gas is purged in to the reactor and solution is stirred till reaction is over.
Step Two: The catalyst is filtered through Nutche filter and then methanol is removed by
distillation.
Step two: Calculated amount of water and acetic acid is added and organic layer so
obtained is concentrated is unloaded in trays for natural cooling for solidification. The
solidified product is then milled to obtain Benzhydrol .
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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Process Flow Chart with Batchwise Raw Material Requirement:
II. 2-(2-Bromoethyl)- Benzaldeyde
Chemical Reaction :
OH
H3PO4, HCl,CH3COOH
CHO
Br
O
(HCHO)n
isochroman
2(2'-bromoethyl)benzaldehyde
C8H10OExact Mass: 122.07Mol. Wt.: 122.16
Product: 2- (2- bromoethyl) benzaldehyde (CAS no:22901-09-3)
Phenethyl alcohol
C9H10OExact Mass: 134.07Mol. Wt.: 134.18
Dichloromethane
C9H9BrOExact Mass: 211.98Mol. Wt.: 213.07
Br2
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Process description:
Step one: Phenethyl alcohol is dissolved in calculated amount of dichloromethane
at room temperature. To this, 85% phosphoric acid, paraformaldehyde, acetic
acid and hydrochloric acid is added and solution is stirred till reaction is over.
Calculated amount of Dichloromethane and water is added, layer separation is
done. Organic dichloromethane layer is separated and washed with sodium
bicarbonate solution. Organic dichloromethane layer is dried over sodium
sulphate and used as such in the next step for bromination.
Step two: To the organic dichloromethane layer, calculated amount of bromine
dissolved in dichloromethane is added and stirred. Then after reaction is over,
dichloromethane is removed by atmospheric distillation. The liquid obtained after
distillation is crude 2-(2-bromoethyl) bromobenzaldehyde.
Step three: The crude product is added to aqueous sodium metabisulfite solution
containing isopropyl alcohol. Dichloromethane is then added and the solid
obtained is centrifuged to obtain powder of metabisulfite adduct of the final
product.
Step four: The metabisulfite adduct is dissolved in calculated amount of water
and sodium carbonate is added to it. The organic product obtained is extracted in
dichloromethane and the dichloromethane layer is washed with water, dried and
concentrated to obtain 2- 2-bromoethyl benzaldehyde as yellow liquid.
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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Process Flow Chart with Batchwise Raw Material Requirement:
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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III. Cinnamyl alcohol
Chemical Reaction :
CHO
C9H8OExact Mass: 132.06Mol. Wt.: 132.16
NaBH4
BH4NaExact Mass: 38.03Mol. Wt.: 37.83
CH30H
CH2OH
C9H10OExact Mass: 134.07Mol. Wt.: 134.18
Cinnamic aldehyde Cinnamyl alcohol
Process Description:
➢ Cinnamic aldehyde is dissolved in calculated amount of methanol at room
temperature. To this, sodium borohydride dissolved in sodium hydroxide solution
is added slowly.
➢ The reaction is maintained till all Cinnamic aldehyde is consumed.
➢ Methanol is removed by distillation and water is added to the reaction mixture
➢ Acetic acid is then added to neutralize the reaction.
➢ Lower aqueous layer is removed which goes to MEE ETP .
➢ Organic upper layer is taken up for vacuum distillation to obtain pure Cinnamyl
alcohol.
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Process Flow Chart with Batchwise Raw Material Requirement
IV. Diethyl Amine Salicylate
Chemical Reaction :
OH
COOH
C7H6O3
Exact Mass: 138.03Mol. Wt.: 138.12
OH
COOH
HN
C11H17NO3
Exact Mass: 211.12Mol. Wt.: 211.26
Salicylic acid Diethyl amine salicylate
HN
Toluene
C4H11NExact Mass: 73.09Mol. Wt.: 73.14
Process Description:
➢ Calculated amount of toluene is taken to which calculated amount of salicylic
acid is added.
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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➢ Then the reaction mass is cooled and calculated amount of diethyl amine is
added slowly.
➢ The reaction mass is stirred till reaction is over.
➢ Then the desired product precipitates out.
➢ The product obtained is centrifuged and dried.
Process Flow Chart with Batchwise Raw Material Requirement
V. Ethyl Triphenyl Phosphonium Bromide
Chemical Reaction :
P
C18H15PExact Mass: 262.09Mol. Wt.: 262.29
C2H5BrExact Mass: 107.96Mol. Wt.: 108.97
Toluene
P
Br
C20H20BrPExact Mass: 370.05Mol. Wt.: 371.25
Triphenyl phosphineEthyl triphenyl phosphonium bromide
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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Process Description:
➢ Calculated amount of triphenyl phosphine is dissolved in toluene and ethyl
bromide is added and reaction is stirred till the reaction is over.
➢ The reaction mass is centrifuged to obtain triphenyl phosphonium bromide
powder which is washed with toluene.
➢ The Mother liquor obtained after centrifuge is distilled to recover toluene which
is again used in the next batch.
➢ The residue obtained after distillation is reused in the next batch.
Process Flow Chart with Batchwise Raw Material Requirement
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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VI. Isosorbide
Chemical Reaction:
HO
OH
OH
OH
OH
OH
C6H14O6
Exact Mass: 182.08Mol. Wt.: 182.17
sorbitol
SO3H
C7H8O3SExact Mass: 172.02
Mol. Wt.: 172.2
O
OH
O
H
HHO
C6H10O4
Exact Mass: 146.06Mol. Wt.: 146.14
isosorbide
Process Description:
➢ Calculated amount of 70% sorbitol is taken to which para toluene sulfonic acid is
added.
➢ The reaction mass is heated to remove water from the reaction.
➢ Then the reaction mass is cooled and then sodium bicarbonate solution is added
for neutralization.
➢ Then water is removed from the reaction mass by heating under vacuum.
➢ Then isosorbide is obtained by distillation under vacuum
Process Flow Chart with Batchwise Raw Material Requirement
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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VII. Isosorbide-2-acetate
Chemical Reaction:
O
OH
O
H
HHO
C6H10O4
Exact Mass: 146.06Mol. Wt.: 146.14
isosorbide
(CH3CO)2O
C4H6O3
Exact Mass: 102.03Mol. Wt.: 102.09
O
OH
O
H
HH3COCO
C8H12O5
Exact Mass: 188.07Mol. Wt.: 188.18
isosorbide -2- acetate
Process description:
➢ Calculated amount of isosorbide is taken to which sodium acetate is added.
➢ Then calculated amount of acetic anhydride is added
➢ The reaction mass heated and then acetic acid formed in the reaction is distilled
out
➢ Then distillation is continued under vacuum and isosorbide -2- acetate is distilled
under vacuum at 200 to 220 degree.
Process Flow Chart with Batchwise Raw Material Requirement
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VIII. Bromo Methyl Cyano Biphenyl
Chemical Reaction:
CN
C14H14
Exact Mass: 182.11Mol. Wt.: 182.26
Br2
MDC, H2O2
AIBNCN
Br
C14H10BrNExact Mass: 271Mol. Wt.: 272.14
2-cyano-4-methyl biphenyl 4-bromo methyl cyano biphenyl
Process Flow Chart with Raw Material Requirement
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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IX. Tetrabutyl Ammonium Bromide
Chemical Reaction:
N
C12H27NExact Mass: 185.21Mol. Wt.: 185.35
Br
C4H9BrExact Mass: 135.99
Mol. Wt.: 137.02
N
Br
C16H36BrNExact Mass: 321.2Mol. Wt.: 322.37
Tr-n-butyl amine tetra butyl ammonium bromide
Process description:
➢ Calculated amount of acetonitrile is taken to which calculated amount of tri-n-
butyl amine is added.
➢ Then calculated amount of n-butyl bromide is added slowly.
➢ The reaction mass is heated till reaction is over.
➢ Then calculated amount of ethyl acetate is added and then acetonitrile and other
volatiles are distilled out.
➢ The reaction mass is cooled and product obtained is centrifuged and dried to
obtain tetra n-butyl ammonium bromide.
Process Flow Chart with Batchwise Raw Material Requirement
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X. Isatoic Anhydride
Chemical Reaction:
NH
O
O
C8H5NO2
Exact Mass: 147.03Mol. Wt.: 147.13
NaOH/ Cl2
NH
O
O
O
C8H5NO3
Exact Mass: 163.03Mol. Wt.: 163.13
PhthalimideIsatoic anhydride
Process description:
➢ Calculated amount of ice and sodium hydroxide solution is taken.
➢ Chlorine gas is purged till reaction is over.
➢ The solution obtained is sodium hypochlorite solution. This solution is used for
next step
➢ In next step, calculated amount of phthalimide is taken to which water is added.
➢ To the reaction mass, sodium hydroxide solution is added.
➢ Then the reaction mass is cooled and then sodium hypochlorite solution prepared
above is added.
➢ Then after reaction is over, hydrochloric acid is added to neutralize the reaction.
➢ The solid obtained is centrifuged and dried to obtain isatoic anhydride.
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Process Flow Chart with Batchwise Raw Material Requirement
XI. Tri-O-Tolyl Phosphine
Chemical Reaction:
Cl
C7H7ClExact Mass: 126.02
Mol. Wt.: 126.58
Mg/THF
PCl3
Cl3PExact Mass: 135.88Mol. Wt.: 137.33
P
C21H21PExact Mass: 304.14Mol. Wt.: 304.37
O-chloro toluene
Tri-ortho tolyl phosphine
Process description:
➢ Calculated amount of magnesium and dry tetrahydofuran is taken is taken to which
small amount of o-chloro toluene is added for initiation.
➢ Then remaining amount of o-chloro toluene is added slowly.
➢ Then phosphorous trichloride in toluene is added to the reaction mass.
➢ Stirring is continued till reaction is over.
➢ Then the reaction mass is quenched in water containing hydrochloric acid.
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➢ The product obtained is centrifuged to obtain crude tri-o-tolyl phosphine.
➢ The product is then recrystallized using calculated amount of isopropyl alcohol.
➢ The product obtained is centrifuged and dried to obtain final pure tri-o-tolyl
phosphine.
Process Flow Chart with Batchwise Raw Material Requirement
XII. Meta Chloro Propiophenone
Chemical Reaction:
O
C9H10OExact Mass: 134.07Mol. Wt.: 134.18
AlCl3Exact Mass: 131.89Mol. Wt.: 133.34
Cl2Exact Mass: 69.94Mol. Wt.: 70.91
O
Cl
C9H9ClOExact Mass: 168.03Mol. Wt.: 168.62
Propiophenone 3-chloro propiophenone
Process description:
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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➢ Calculated amount of propiophenone is taken to which calculated amount of
Ethylene dichloride is added.
➢ The reaction mass is chilled and calculated amount of aluminium chloride is
added to it.
➢ Then chlorine gas is purged into the reaction mass under chilled conditions.
➢ After reaction is over, the reaction mass is quenched in cold water containing
HCl.
➢ The organic layer is removed and washed with sodium bicarbonate solution for
neutralization.
➢ Then ethylene dichloride is recovered by distillation to obtain crude 3-chloro
propiophenone which is vacuum distilled to obtain pure 3-chloro
propiophenone.
Process Flow Chart with Batchwise Raw Material Requirement
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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XIII. 3-Chloro,4-N-Morpholino, 1,2,5 Thiadiazole
Chemical Reaction:
H2N
NH2.2HCl
Ethylene diamine dihydrochloride
N
NS
Cl
Cl
O NH
N
NS
Cl
N O
3,4-dichloro-1,2,5-thiadiazole
3-chloro-4-(N-morpholino)- 1,2,5-thiadiazole
C2H10Cl2N2
Exact Mass: 132.02Mol. Wt.: 133.02
Cl2S2Exact Mass: 133.88
Mol. Wt.: 135.04
Cl2Exact Mass: 69.94
Mol. Wt.: 70.91
C2Cl2N2SExact Mass: 153.92
Mol. Wt.: 155.01
C4H9NOExact Mass: 87.07
Mol. Wt.: 87.12
C6H8ClN3OSExact Mass: 205.01
Mol. Wt.: 205.67
Process description:
Step one:
➢ Ethylene diamine dihydrochloride is dissolved in Dimethyl formamide.
➢ The solution is stirred and sulfur monochloride is added.
➢ Then solution is cooled and chlorine gas is purged in the reaction mixture till the
reaction is over.
➢ Then water is added and stirred.
➢ Organic layer is taken up for vacuum distillation.
➢ 3,4-dichloro thiadiazole which gets distilled is obtained as yellow liquid .
Step two:
➢ 3,4 dichloro thiadiazole obtained in first step is dissolved in calculated amount of
morpholine.
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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➢ The reaction is heated for 2 hours till reaction is complete.
➢ Then the reaction mass is cooled and Hydrochloric acid is added .
➢ After addition , solid precipitates which is filtered and dried to obtain 3- chloro-4-N-
morpholino 1,2,5- thiadiazole.
Process Flow Chart with Batchwise Raw Material Requirement
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
Page 32 of 43
XIV. 4-Methoxy Propiophenone
Chemical Reaction:
OCH3
C7H8OExact Mass: 108.06
Mol. Wt.: 108.14
(CH3CH2CO)2O
C6H10O3
Exact Mass: 130.06Mol. Wt.: 130.14
OCH3
O
C10H12O2
Exact Mass: 164.08Mol. Wt.: 164.2Anisole
4-methoxy propiophenone
Process description:
➢ Calculated amount of anisole and propionic anhydride is taken.
➢ Then calculated amount of zeolite catalyst is added slowly.
➢ Then reaction is refluxed till reaction is over
➢ The excess anisole and propionic acid formed is distilled and anisole is reused in
next batch.
➢ Then 4-methoxy propiophenone is distilled under vacuum.
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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Process Flow Chart with Batchwise Raw Material Requirement
XV. Anethole
Chemical Reaction:
OCH3
O
C10H12O2
Exact Mass: 164.08Mol. Wt.: 164.2
4-methoxy propiophenone
Ni/ H2
or NaBH4
OCH3
HO
C10H14O2
Exact Mass: 166.1Mol. Wt.: 166.22
KHSO4
HKO4SExact Mass: 135.92Mol. Wt.: 136.17
OCH3
C10H12OExact Mass: 148.09
Mol. Wt.: 148.2
Anethole
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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Process Description:
➢ Calculated amount of 4-mehoxy propiophenone is taken in methanol.
➢ Then the reaction mass is hydrogenated using hydrogen and raney nickel as catalyst
or using sodium borohydride
➢ After reaction is over, the catalyst is filtered and solvent is removed to obtain the
reduced product.
➢ This reduced product is treated with potassium hydrogen sulfate and mineral oil.
➢ The reaction is refluxed and distilled to obtain anethole as clear liquid.
Process Flow Chart with Batchwise Raw Material Requirement
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
Page 35 of 43
VI. Raw Material Required
Batchwise raw material requirement is detailed out in process flow chart presented in
Section 3 of V.
VII. List of Plant Machineries
Details of plant equipment’s are presented in Table No. 3
Table No. 3: Details of plant equipment’s
PARTICULAR POWER PARTICULAR POWER
Lab Instruments 7.5 HP Air Compressor 2 HP
Lab Vacuum Pump 1 HP Scrubber No. 1 2 HP
Reactor No.1 5 HP Scrubber No. 2 2 HP
Reactor No. 2 5 HP Scrubber No. 3 2 HP
Reactor No. 3 5 HP Scrubber No. 4 2 HP
Reactor No. 4 5 HP High vacuum distillation Unit 5 HP
Reactor No. 5 5 HP Glass flask No. 1 0.5 HP
Reactor No. 6 5 HP Glass flask No. 2 0.5 HP
Reactor No. 7 5 HP Glass flask No. 3 0.5 HP
Reactor No. 8 5 HP Glass flask No. 4 0.5 HP
Centrifuge No. 1 7.5 HP Glass flask No. 5 0.5 HP
Centrifuge No. 2 7.5 HP Glass flask No. 6 0.5 HP
Centrifuge No. 3 7.5 HP Air Handling Unit (AHU) 5 HP
Centrifuge No. 4 7.5 HP ETP 23.45 HP
Centrifuge No. 5 7.5 HP Lighting Load 2.6 HP
Dryer No. 1 5 HP FAN 1.25 HP
Dryer No. 2 5 HP AC 2 HP
Nutch filter 2 HP
Sparkler filter No. 1 1 HP
Sparkler filter No. 2 1 HP
Pressure filter No. 3 1 HP
Pressure filter No. 4 1 HP
Multimill No. 1 3 HP
Multimill No. 2 3 HP
Boiler No. 1 5 HP
Boiler No. 2 5 HP
Chilling Plant 40 HP
Cooling Tower 15 HP
Vacuum Pump Watering No. 1 5 HP
Vacuum Pump Watering No. 2 5 HP
Water Pump 3 HP
High Vacuum Pump 5 HP
Softener Pump 1 HP
Filter Pump No. 1 2 HP
Filter Pump No. 2 2 HP
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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Filter Pump No. 3 2 HP
Vacuum Pump Oil ring 5 HP
VIII. Resource optimization/recycling and reuse
Proposed expansion is related to change in products only. Existing resource such as
infrastructure, equipment’s and manpower will be used in proposed expansion.
Industry is in practice to recycle & reuse waste water for gardening. The same practice
will be adopted in proposed expansion also.
IX. Auxiliary Requirement
Details of auxiliary requirement & it source are presented below
Table No. 4: Details of Auxiliary
Sr.No. Auxiliary Requirement Source
1. Water 12 CMD MIDC
2. Power 95 kVA MSEDCL
3. DG Set 50 kW Solar Energy
4. Cooling Tower
5. Boiler
X. Waste Generation & Management
Construction Phase: There is no construction in proposed expansion hence no solid
waste generation.
Operation Phase: Domestic waste would be generated in the form of dry waste 9
kg/day & 3 kg/day of wet waste. It will be collected at designated place and
disposed-off through authorized vendor.
Commercial Waste : Wooden box, raw chemical plastic drum etc. would be disposed
off through authorized vendor.
Industrial Waste: Hazardous waste will be sent to CHWTSDF facility and non-
hazardous waste will be recycled through authorized vendor.
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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XI. Schematic representations of the feasibility drawing which give information of EIA
purpose.
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4. Site Analysis
I. Connectivity
The project site is in MIDC-Paithan, well connected through road, railway, and airport.
Nearest highway is SH-30 i.e. Aurangabad to Paithan which is about 0.7km from the
project site. Nearest Railway station & Airport is in Aurangabad which is at 36km
(Aerial) from project site.
II. Land Form, Land Use & Land ownership
Project site is spread in to 6840 Sq.M. area. Industry is located in notified industrial
MIDC area. Land use is for industrial activity only and land ownership is of MIDC and
taken on lease in the name of M/s. Satellite Pharmaceuticals Pvt. Ltd.
III. Topography
M/s. Satellite Pharmaceuticals Pvt. Ltd. is already established unit and located in MIDC
area. Topography of developed site is flat. For expansion purpose, no any additional
land or construction activity required.
IV. Existing Land use pattern
Land is already developed for industrial purpose. Total plot area of M/s. Satellite
Pharmaceuticals Pvt. Ltd is 6840 Sq.M. Site is located in well-developed Paithan MIDC
area. Surrounding area is already developed for industrial purpose.
V. Existing Infrastructure
Project site is having existing MIDC’s infrastructure such as road, water supply,
electricity etc., other societal infrastructure around proximity of project site is
presented in Table No. 5.
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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Table No. 5.: Societal infrastructure
Particular Name Distance from
project site
(Km)
Direction
from project
site
Airport Aurangabad 36 N
Railway Station Aurangabad 36 N
Highway Aurangabad-Paithan (SH-
30)
0.7 W
Industrial area Paithan MIDC 0.0 within
Fire Station Paithan MIDC Fire station 0.9 SW
Waluj MIDC Fire station 35 NW
Hospital Bhujbal Hospital 0.8 W
Dhanwantari Hospital 0.9 SW
Police station Paithan Police Station 8.0 S
Tourist Places Paithan 6.0 S
Settlement Mudhalwadi 1.3 SE
VI. Soil Classification
The most important soils of the district are the black clay soils on plains interspersed
with occasional stretches of shallow soils on ridges. In the north, the soils are shallow
and poor and in the south they are deep and fertile and particularly so in the Godavari
valley. They are all derived from Deccan trap. The soils can be classified as light,
medium and heavy according to the depth, texture and location.
VII. Climate data from secondary sources
Aurangabad has a semiarid climate. Annual mean temperatures in Aurangabad range
from 17 to 33 °C, with the most comfortable time to visit in the winter – October to
February. The highest maximum temperature ever recorded was 46 °C (114 °F) on 25
May 1905. The lowest recorded temperature was 2 °C (36 °F) on 2 February 1911. In
the cold season, the district is sometimes affected by cold waves in association with
the eastward passage of western disturbances across north India, when the minimum
temperature may drop down to about 2 °C to 4 °C (35.6 °F to 39.2 °F).
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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Most of the rainfall occurs in the monsoon season from June to September.
Thunderstorms occur between November to April. Average annual rainfall is 710 mm.
The city is often cloudy during the monsoon season and the cloud cover may remain
together for days. The daily maximum temperature in the city often drops to around
22 °C due to the cloud cover and heavy rains.
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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5. PLANNING BRIEF
I. Planning Concept
In proposed expansion there will be no construction works involved. Industry is in
operation with chemicals without bulk drug manufacturing. Existing industrial
infrastructures are adequate for proposed expansion. Hence there is no planning in
detailed will be required.
II. Population Projection
Site is located at developed Paithan MIDC area. There is no manpower requirement
in proposed expansion.
III. Land use Planning
Land is already developed for industrial purpose.
IV. Assessment of Infrastructure Demand
Project site is in MIDC area, all infrastructure provided by the MIDC, hence additional
infrastructure demand will be negligible.
V. Amenities/Facilities
In proposed expansion addition 5CMD of effluent treatment plant will be required
followed by Multi Effect Evaporator to achieve Zero Liquid Discharge (ZLD) Scheme.
Plot Area : 6840 .00 Sq.M.
Built-Up Area : 1570.39 Sq.M
Open Area : 2770.00 Sq.M.
Green Belt Area : 2000.00 Sq.M
Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad
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6. Proposed Infrastructure
I. Industrial Area
Project site is in Paithan MIDC area, no additional land or plot will be required for the
expansion purpose.
II. Residential Area
No residential area is involved.
III. Green Belt
Industry is already developed 2000.00 Sq.M. of area as a green belt.
IV. Social Infrastructure
No any additional infrastructure proposed as project is in MIDC
V. Connectivity
As a existing industry situated in Paithan MIDC, Industry is well connected through
highway & internal roads. No new road is proposed.
VI. Drinking Water
Domestic water demand is 2 CMD and there is no additional requirement in proposed
requirement. Source of water is MIDC.
VII. Sewerage System
Existing industry has sewerage system for collection of domestic sewage. That sewage
is treated in septic tank followed by soak pit.
VIII. Industrial Waste Management
Industrial waste segregated as hazardous & non-hazardous. Hazardous waste will be
sent to CHWTSDF and non-hazardous waste will be disposed off through authorized
vendor.
IX. Solid Waste Management
Domestic waste categorized as dry & wet waste. Quantified dry waste 9 kg/day & 3
kg/day of wet waste are being collected at designated place and disposed-off
through authorized vendor.
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X. Power Requirement
Existing power requirement is 95 kVA and connected load is 187 kVA. Source of power
is MIDC/MSEDCL. Client has proposed to install 50 kW solar panel as an alternate
green energy source in proposed expansion.
7. Rehabilitation and Resettlement (R & R) Plan
As a project site is located in Paithan MIDC area there is no applicability of R & R. for
the said project.
8. Project Schedule & Cost Estimates
I. Likely date to start of Construction & likely date of completion
M/s. Satellite Pharmaceuticals Pvt. Ltd, is already existing industry in Paithan MIDC.
For proposed expansion industry does not required any construction activity.
Manufacturing of proposed synthetic organic chemicals process will start after getting
Environment Clearance from Authorities & Consent to Operate from MPCB.
II. Estimated Project Cost
Estimated cost of the project for expansion purpose is ₹. 100 Lakhs . Total cost of the
project after expansion would be ₹. 470 Lakhs (Existing & Proposed).
9. Analysis of Proposal
I. Financial & Social Benefits
M/s. Satellite Pharmaceuticals proposed expansion with respect to manufacturing of
synthetic organic chemicals as Intermediates for bulk drug , which will be used as a
raw material for preparation of various medicines for curing different diseases in social
community & help to maintain healthy life. Thus the project having social benefits in
term of production of raw material for medicines.
In financial point of view, proposed synthetic organic chemicals can be exported to
various countries it will help full to generate revenue & various taxes.