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Preliminary Program Falk Symposium 192 IBD 2014: Thinking Out of the Box May 30 – 31, 2014 Le Palais des Congrès de Paris Paris, France Application for CME credits submitted
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Preliminary Program

Falk Symposium 192

IBD 2014:Thinking Out of the Box

May 30 – 31, 2014Le Palais des Congrès de ParisParis, France

Application for CME credits submitted

3

Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4

Scientific Program. . . . . . . . . . . . . . . . . . . . . . . . . . 6

Posters. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10

List of Speakers, Moderators and Scientific Organizers . . . . . . . . . . . . . . . . . . . . . . . . 11

Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15

CME credits for the Falk Symposium 192 have been applied for at the European Union of Medical Specialists (UEMS) – European Board of Gastroenterology (EBG). The number of credits awarded will be printed in the final program.

4

Preface

Dear Colleagues,

Significant scientific progress has been made in recent years in the etiopathogenesis of inflammatory bowel diseases (IBD) that has changed or will shortly change the current management of IBD.

The relevance of well-established IBD therapies has been critically re-evaluated under criteria of evidence-based medicine approaches and new therapeutic strategies have emerged. New therapeutic options are assessed in an increasing number of clinical trials and include alternative immunomodulatory approaches, biologics, probiotics, worm eggs, lecithins, cell-based therapies and others. The clinical relevance of these new modalities is still difficult to assess, as physicians have only limited experience with these modalities beyond clinical trials, where patients are highly selected and do often not represent the general IBD population. The availability of more treatment options results in even more different treatment algorithms including various sequences of medical or surgical approaches.

This symposium aims to critically discuss established and emerging new concepts in the management of IBD reflecting the recent advancements. Controversial problems, emerging new treatment options, new therapeutic strategies and a view outside our current pathways and look across our own horizon will be addressed. Difficult therapeutic situations will be critically analyzed and discussed. The program is designed to provide opportunities for discussion, and a lively interaction between the speakers, moderators and the audience is expected.

Axel Dignass

Chairman of the Scientific Committee

5

Registration:Thursday, May 29, 201416.00 – 21.00 hat the congress offi ce

Scientifi c Organization:M. Allez, Paris (France)S. Danese, Rozzano (Italy)A. Dignass, Frankfurt (Germany)P. Marteau, Paris (France)

Congress Venue:Le Palais des Congrès de Paris2 Place de la Porte Maillot75853 Paris Cedex 1France

Information:Prof. Dr. Axel DignassInnere Medizin IAgaplesion Markus KrankenhausWilhelm-Epstein-Str. 460431 FrankfurtGermanyTelephone: +49 (0)69/9533-2201Telefax: +49 (0)69/9533-2291E-Mail: [email protected]

Offi cial Language:English.Simultaneous translation into French.

Posters:For details see page 10.

Publication Date of the Final Program: May 2014

The fi nal program will be available on the homepage www.falkfoundation.org one week before.

Falk Symposium 192

IBD 2014:Thinking Out of the Box

May 30 – 31, 2014Le Palais des Congrès de ParisParis, France

6

Friday, May 30, 2014

9.00 Welcome A. Dignass, Frankfurt

Session I Environment and the flora in IBD: Partners in crime?

Chair: W. Kruis, Cologne; P. Marteau, Paris

9.10 What have we learnt about the role of environment B. Moum, and natural course of IBD in the new millennium? Oslo 20 year follow-up of the IBSEN Cohort

9.30 Probiotics and Antibiotics H. Sokol, Paris

9.50 Fecal transplantation in IBD J. Raes, Brussels

10.10 Flora manipulation through diet and modified J. M. Rhodes, bacteria Liverpool

10.30 Coffee break with poster session

Session II Fibrosis in IBD

Chair: P. L. Lakatos, Budapest; G. Rogler, Zurich

11.00 Mechanisms and models for intestinal fibrosis T. Torres Pizarro, Cleveland

11.20 Clinical Management of intestinal stenosis: G. van Assche, Pro: Conservative endoscopic and medical treatment Leuven

11.40 Clinical Management of intestinal stenosis: A. D’Hoore, Pro: Surgical treatment Leuven

12.00 New therapeutic avenues for treatment of fibrosis: G. Rogler, Can we learn from other diseases? Zurich

12.20 Lunch break with poster session

7

Friday, May 30, 2014

Session III Cell-based therapies

Chair: J. Panés, Barcelona; W. Reinisch, Vienna

14.00 Cardiac Stem cell transplantation – A. M. Zeiher, What can we learn from the cardiologist? Frankfurt

14.20 Hematopoetic stem cell transplantation M. Allez, Paris

14.50 Mesenchymal stem cell transplantation L. Egan, Galway

15.10 Immune cell therapy to treat IBD J.-F. Colombel, New York

15.30 Coffee break with poster session

Special Lecture Chair: M. Allez, Paris; S. Danese, Rozzano

16.00 Cytokines for IBD: Past, present and future S. Schreiber, Kiel

Session IV New therapies or new therapeutic strategies in IBD?

Chair: B. Siegmund, Berlin; C. J. van der Woude, Rotterdam

16.30 Trichiuris suis ova, lecithin and other fancy molecules J. Schölmerich, Frankfurt

16.50 New drugs on the horizon for IBD B. E. Sands, New York

17.10 Treat the lesions or treat the symptoms? G. D’Haens, New treatment algorithms Amsterdam

17.30 The clinical studies that should be performed in IBD J. Panés, Barcelona

17.50 End of afternoon session

8

Saturday, May 31, 2014 Session V

Best use of biologics in 2014 Chair: Y. Bouhnik, Clichy; F. Magro, Porto

9.00 Starting and stopping anti-TNF drugs R. Panaccione, Calgary

9.20 Can anti-TNF therapy change the course of disease? A. Sturm, Berlin

9.40 Biosimilars: Are they bioequivalent? F. Gomollón, Zaragoza

10.00 Tailoring treatment to the individual patient: W. J. Sandborn, Drug monitoring La Jolla

10.20 Coffee break with poster session

Session VI Current role of immunosuppressants in IBD

Chair: L. Beaugerie, Paris; H. Tilg, Innsbruck

10.50 Optimal treatment of early CD and UC E. Louis, Liège

11.10 Treatment of established CD and UC – J. Cosnes, Still a role for Aza Paris

11.30 Special situations: Perianal disease and S. Ghosh, postoperative period Calgary

Special Lecture Chair: A. Dignass, Frankfurt; P. Marteau, Paris

11.50 Integrating omics: The future in IBD? C. Fiocchi, Cleveland

12.20 Lunch break with poster session

9

Saturday, May 31, 2014 Session VII

The complicated IBD patient: Clinical case marathon

Chair: W. A. Bemelman, Amsterdam; L. Peyrin-Biroulet, Nancy

13.20 Presentation of Poster Prizes A. Dignass, Frankfurt

13.30 Tandem talk: A patient with Crohn’s disease and F. Carbonnel, intra-abdominal infection (abscess): The place and Le Kremlin Bicetre timing of biologics and surgery W. A. Bemelman, Amsterdam13.55 Tandem Talk: Refractory distal ulcerative colitis – Is always proctocolectomy necessary?

Pro: Proctocolectomy A. Spinelli, Rozzano

Con: Proctocolectomy E. F. Stange, Stuttgart

14.20 Previous cancer and/or lymphoma in patients with refractory IBD:

Pro: Anti-TNF or immunosuppressive treatment D. Laharie, Pessac

Con: Anti-TNF or immunosuppressive treatment G. Mantzaris, Athens

14.45 Refractory pouchitis: Probiotics, immunosuppressive I. Dotan, therapy or pouch removal? Tel Aviv

15.10 Closing Remarks P. Marteau, Paris

15.20 End of afternoon session

10

Poster SessionPosters will be exhibited on May 30-31, 2014 in the Le Palais des Congrès de Paris. The authors will be in attendance during coffee and lunch breaks on both days.

Call for PostersPlease submit your poster abstract before January 31, 2014. Only one-page abstracts not exceeding 300 words, written in English and saved in Microsoft Word format will be accepted.

Abstracts must be submitted via our Internet Abstract Submission System (http://www.falkfoundation.org/poster) where further information regarding the submission format and the submission process is available.

The abstracts will be selected by the scientific organizers, preference being given to those thematically related to one of the sessions of the program.

The accepted abstracts will be printed and distributed to the participants of the congress together with the documents of the meeting.

The authors will receive notification about acceptance and further instructions in February 2014.

Contact address for further information on the poster session:

Falk Foundation e. V. Congress Department Leinenweberstr. 5 79108 Freiburg (Germany) Telephone: +49 (0)761/1514-0 Telefax: +49 (0)761/1514-359 Web address for submitting poster abstracts: http://www.falkfoundation.org/poster

For the first author of an accepted poster, expenses for accommodation (May 29 – June 1, 2014) and fees for the scientific program and evening activities will be covered during the Falk Symposium 192. Travel expenses will not be covered.

Poster PrizesThree prizes will be awarded for the best presentations. Prize winners will be presented with a certificate and prize money for € 1.500,-, € 1.000,- and € 500,- respectively. Travel expenses will be covered additionally for the first author of prize winning posters.

11

List of Speakers, Moderators and Scientific Organizers

Prof. Dr. Matthieu AllezHôpital Saint-LouisService de Gastroentérologie1 Ave. C. Vellefaux75010 [email protected]

Prof. Dr. Gert van AsscheUniversity ZiekenhuisGasthuisbergGastro-entérologieHerestraat 493000 [email protected]

Prof. Dr. Laurent BeaugerieHôpital Saint AntoineDepartment of Gastroenterology184, Rue du Faubourg St.-Antoine75571 [email protected]

Prof. Dr. Willem A. BemelmanAcademic Medical CenterMeibergdreef 91105 AZ AmsterdamThe [email protected]

Prof. Dr. Yoram BouhnikHôpital BeaujonUniversité Paris VIIDept. of Gastroenterology100 bd général Leclerc92110 [email protected]

Prof. Dr. Franck CarbonnelCHU de BicêtreUniversité Paris SudService d‘Hépatogastroentérologi78 rue du Général Leclerc94275 Le Kremlin [email protected]

Prof. Dr. Jean-Frederic ColombelProfessor of MedicineMount Sinai School of MedicineGastroenterology & HepatologyOne Gustave L. Levy PlaceNew York NY [email protected]

Prof. Dr. Jacques CosnesHôpital Saint AntoineService de Gastroentérologie& Nutrition du Prof. Gendre184, Rue du Faubourg St.-Antoine75571 [email protected]

Dr. Silvio DaneseIstituto Clinico Humanitas IRCCSIRCCS in GastroenterologyVia Manzoni, 5620089 [email protected]

Prof. Dr. Geert D‘HaensAcademic Medical CenterAfdeling MDL C2-112Meibergdreef 91105 AZ AmsterdamThe [email protected]

Prof. Dr. André D‘HooreUniversity ZiekenhuisGasthuisbergDept. Abdominal SurgeryHerestraat 493000 [email protected]

12

Prof. Dr. Axel DignassInnere Medizin IAgaplesion Markus KrankenhausWilhelm-Epstein-Str. 460431 FrankfurtGermany [email protected]

Dr. Iris DotanTel Aviv Medical CenterIchilov HospitalDepartment of Gastroenterology6, Weizman Street64239 Tel [email protected]

Prof. Dr. Laurence EganNational University of IrelandDepartment of Pharmacology& [email protected]

Claudio Fiocchi, M.D.Professor of MedicineThe Cleveland Clinic FoundationPathobiology / NC 209500 Euclid AvenueCleveland OH [email protected]

Prof. Dr. Subrata GhoshUniversity of CalgaryFoothills HospitalDepartment of Gastroenterology1403 29th St. NWCalgary AB T2N [email protected]

Dr. Fernando GomollónHospital Clinico UniversitarioLosano BlesaAvenida San Juan Bosco 1550009 [email protected]

Prof. Dr. Wolfgang KruisInnere MedizinEvang. Krankenhaus KalkBuchforststr. 251103 Kö[email protected]

Prof. Dr. David LaharieHôpital Haut-Lévêque1 avenue Magellan33604 Pessac [email protected]

Prof. Dr. Peter L. LakatosSemmelweis UniversityMedical SchoolI Department of MedicineKoranyi u. 2/a1083 BudapestHungarylakatos.peter_laszlo@ med.semmelweis-univ.hu

Prof. Dr. Edouard LouisC.H.U. Sart TilmanGastroentérologieDomain du Sart Tilman4000 Liè[email protected]

Dr. Fernando MagroHospital de S. JoaoServico de GastroenterologiaAv. Prof. Hernani Monteiro4200-319 [email protected]

Prof. Dr. Gerassimos MantzarisEvangelismos HospitalDept. of Gastroenterology45-47, Ipsilantou str.106 75 [email protected]

13

Prof. Dr. Philippe MarteauLariboisiere HôpitalService d‘Hepato-Gastroenterologie2, rue Ambroise Paré75010 [email protected]

Prof. Dr. Bjorn MoumAker University HospitalDivision of GastroenterologyTrondheimsveien 2350514 [email protected]

Prof. Dr. Remo PanaccioneUniversity of CalgaryInflammatory Bowel DiseaseClinic, Room 6D30, TRW Building3280 Hospital Drive N.W.Calgary AB T2N [email protected]

Prof. Dr. Julián PanésHospital Clinico y ProvincialUniversidad de BarcelonaInflammatory Bowel Disease Unitc/ Villarroel no. 17008036 [email protected]

Prof. Dr. Laurent Peyrin-BirouletHôpitaux de BraboisC.H.U. de NancyDept. of Hepato-GastroenterologyAllee du Morvan54511 [email protected]

Prof. Dr. Jeroen RaesBioinformatics and (eco-)systems biologyDepartment of Structural BiologyVIB - Vrije Universiteit BrusselPleinlaan 21050 [email protected]

Prof. Dr. Walter ReinischMedizinische Universität WienGastroenterologie/HepatologieWähringer Gürtel 18-201090 [email protected]

Prof. Dr. Jonathan M. RhodesDepartment of GastroenterologyFaculty of Health and Life SciencesUniversity of LiverpoolDuncan BuildingDaulby StreetLiverpool L69 3GAGreat [email protected]

Prof. Dr.Dr. Gerhard RoglerUniversitätsspital ZürichKlinik für Gastroenterologie& HepatologieRämistrasse 1008091 Zü[email protected]

William J. Sandborn, M.D.Professor of MedicineUCSD School of MedicineDivision of GastroenterologyBuilding UC 303, Room 2209500 Gilman DriveLa Jolla CA [email protected]

Bruce E. Sands, M.D.Professor of MedicineMount Sinai School of MedicineDepartment of GastroenterologyOne Gustave L. Levy PlaceNew York NY [email protected]

14

Prof. Dr. Jürgen SchölmerichKlinikum der Johann WolfgangGoethe-Universität FrankfurtTheodor-Stern-Kai 760596 [email protected]

Prof. Dr. Stefan SchreiberInnere Medizin IUniversitätsklinikumSchleswig-Holstein, Campus KielArnold-Heller-Straße 3 (Haus 6)24105 [email protected]

Prof. Dr. Britta SiegmundGastroenterologieCharité UniversitätsmedizinCampus Benjamin Franklin (CBF)Hindenburgdamm 3012203 [email protected]

Dr. Harry SokolGastroenterology and Nutrition departmentSaint-Antoine Hospital184, rue du faubourg Saint-Antoine75571 Paris cedex [email protected]

Prof. Dr. Antonio SpinelliUnità Operativa di Chirurgia Generale IIIIstituto Clinico HumanitasVia A. Manzoni, 5620089 [email protected]

Prof. Dr. Eduard F. StangeInnere Medizin IRobert-Bosch-KrankenhausAuerbachstr. 11070376 [email protected]

Prof. Dr. Andreas SturmInnere MedizinKrankenhaus WaldfriedeArgentinische Allee 4014163 [email protected]

Prof. Dr. Herbert TilgUniversitätsklinik InnsbruckInnere Medizin IAnichstr. 356020 [email protected]

Theresa Torres Pizarro, M.D.Associate Professor Case Western Reserve University5129 WRB10900 Euclid AveCleveland, OH [email protected]

Prof. Dr. C. Janneke van der WoudeErasmus Medical CenterAfd. Gastroenterologie´s-Gravenijkwal 2303015 CE RotterdamThe [email protected]

Prof. Dr. Andreas M. ZeiherInnere Medizin IIIKlinikum der Johann WolfgangGoethe-Universität FrankfurtTheodor-Stern-Kai 760596 [email protected]

15

General InformationPrior to the opening of the congress

Falk Foundation e. V. Telephone: +49 (0)761/1514-0Congress Department Telefax: +49 (0)761/1514-359Leinenweberstr. 5 E-mail: [email protected] Freiburg (Germany)

Congress OfficeDuring Falk Symposium 192

Le Palais des Congrès de Paris Telephone: +49 (0)175/7795327 2 Place de la Porte Maillot75853 Paris Cedex 1France

Opening Hours:Thursday, May 29, 2014 16.00 – 21.00 hFriday, May 30, 2014 8.00 – 18.00 hSaturday, May 31, 2014 8.30 – 15.00 h

Congress FeesScientific program of the Falk Symposium 192 € 200,–Students and residents € 100,–

* * * OR * * *

Day ticket € 120,–Students and residents € 60,–

Employees of pharmaceutical companies and their guestsFalk Symposium 192 € 600,-

The congress fees include:- Welcome Evening on May 29, 2014- Refreshments during coffee breaks- Lunch on May 30 and 31, 2014- A copy of the abstract volume

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RegistrationCongress registrations must reach the Falk Foundation e. V. by March 31, 2014 at the latest. Congress fees may be paid by cheque payable to the Falk Foundation e. V. or by bank transfer to Volksbank Freiburg e. G., Germany, Bank No. 680 900 00, Account No. 145 2010, IBAN DE33 6809 0000 0001 4520 10, BIC Genode 61 FR1. Please mark bank transfers with “Falk Symposium 192”.To ensure correct registration, participants are asked to send in their registration and the fee remittance together.After receipt of registration form, each participant will be provided with confirmation of his registration. On presentation of this confirmation at the Congress Office in London participants will receive the congress folder containing name badges, admission tickets and the abstract volume.In the event of registration cancellations, a handling fee of € 20,– will be deducted from the refund. All participants will receive a written confirmation of attendance at the end of the meeting.

Admission to Scientific EventsFor admission to scientific events your name badge should be clearly visible.

Congress ReportThe official congress report of the Falk Symposium 192 “IBD 2014: Thinking Out of the Box” will be published in English in the second half of 2014 by Karger, Switzerland. Orders for this book at a reduced subscription price of € 35,- can be placed at the Congress Office during the congress in Paris.

Congress Short ReportThe congress short report of the Falk Symposium 192 “IBD 2014: Thinking Out of the Box” will be published by the Falk Foundation e.V. with number FSR 192 in the second half of 2014.

AirportsOrly, 40 minsRoissy Charles de Gaulle, 40 mins

RailwaysGare du Nord, Gare de l‘Est, 30 minsGare Saint-Lazare, 20 minsGare Montparnasse, 30 minsGare de Lyon & d‘Austerlitz, 30 mins

SubwayLignes / Lines: 1. RER CStation / Stop: Porte Maillot

Directions to Le Palais des Congrès de Paris

Le Palais desCongrès de Paris

General Information:

FALK FOUNDATION e.V.Leinenweberstr. 579108 FreiburgGermany

Congress DepartmentTelephone: +49(0)761/1514-0Telefax: +49(0)761/1514-359E-mail: [email protected]

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