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EspondiloartritisClínicaDía 23
Dr. Enrique Soriano Guppy
ABSTRACT NUMBER: 2828
Utility of Fecal Calprotectin Levels for the Diagnosis of Inflammatory Bowel Disease in Patients with SpondylorarthritisMaria Espinosa , Consuelo Ramos Giraldez , Carolina Merino , Belen Ruiz Antoran , Jose Campos , Carmen Barbadillo , Hilda Godoy , Belen Agudo , Yago Gonzalez , Jose Luis Andreu and Jesus Sanz , Rheumatology, H.U. Puerta de Hierro, Madrid, Spain
Methods: • Patients consecutively selected in a Rheumatology
Clinic• Fulfilled ASAS SpA criteria• Did not present digestive symptoms suggestive of
IBD. • Pathological FC cut-off point >50 mg/Kg.• Patients with a positive FC test underwent
ileocolonoscopy
ABSTRACT NUMBER: 2787
−21 HLA-Class I Dimorphism Differentiates Psoriatic Arthritis (PsA) from Psoriasis without Psoriatic Arthritis (PsC)Vinod Chandran , Quan Li , Rohan Machhar , Fatima Abji , Justine Y. Ye , Rajan Nair , Philip Stuart , Katerina Oikonomopoulou , James T. Elder , Dafna D Gladman and Proton Rahman , Rheumatology, University of Toronto
Background/Purpose:. HLA class I educates NK cells through interactions with killer cell Immunoglobulin receptors (KIRs) and by supplying peptides that bind HLA-E site of HLA-E. In ~80% of HLA-B allotypes, methionine at position −21M (21M) is replaced by threonine. Methionine −21 delivers functional peptides, whereas threonine at this position (−21T) does not.
Humans divided into 3 groups:• −21M/M,
M/T, T/T• With
decreasing order of potency of NK CD94/NKG2A+
receptor
Conclusion: The study provides indications for a potential role of NK cells in PsA pathogenesis, as well as provides a genetic marker that differentiates PsA from PsC.
ABSTRACT NUMBER: 2787
−21 HLA-Class I Dimorphism Differentiates Psoriatic Arthritis (PsA) from Psoriasis without Psoriatic Arthritis (PsC)Vinod Chandran , Quan Li , Rohan Machhar , Fatima Abji , Justine Y. Ye , Rajan Nair , Philip Stuart , Katerina Oikonomopoulou , James T. Elder , Dafna D Gladman and Proton Rahman , Rheumatology, University of Toronto
ABSTRACT NUMBER: 2827
Remission Targets and Prevention of Subclinical Atherosclerosis in Psoriatic Arthritis- Which Target Should We Choose?Isaac T. Cheng , Qing Shang , Edmund Kwok Ming Li , Priscilla Wong , Lydia Ho Pui Tam , Tracy Y. Zhu , M Mimi Chang , JW Jack LEE , PW Alex Lee and Lai-Shan Tam , Department ofMedicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong
Conclusion:Achievement of sMDA was associated with protective effect in subclinical atherosclerosis and arterial stiffness progression but not sDAPSA-LDA. Multidimensional domain of disease control is preferable for minimizing CV risk in PsA.
ABSTRACT NUMBER: 2827
Remission Targets and Prevention of Subclinical Atherosclerosis in Psoriatic Arthritis- Which Target Should We Choose?Isaac T. Cheng , Qing Shang , Edmund Kwok Ming Li , Priscilla Wong , Lydia Ho Pui Tam , Tracy Y. Zhu , M Mimi Chang , JW Jack LEE , PW Alex Lee and Lai-Shan Tam , Department ofMedicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong
ABSTRACT NUMBER: 2830
Synovitis in Psoriatic Arthritis and Seronegative Rheumatoid Arthritis: Differential Histological FeaturesStefano Alivernini , Dario Bruno , Anna Laura Fedele , Luca Petricca , Giusy Peluso , Domenico Birra , Barbara Tolusso , Laura Bui , Francesco Federico , Gianfranco Ferraccioli and Elisa Gremese , Division ofRheumatology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Catholic University of the Sacred Heart, Rome, Italy
Conclusion: CD117 and CD138 cells are differentially distributed among PsA and Ab RA. Histological analysis of ST may help to solve the clinical overlap between the two diseases and provides prognostic data about the therapy success.
ABSTRACT NUMBER: 2134
Modifiable Risk Factors and the Development of Psoriatic Arthritis in People with PsoriasisAmelia Green1,2, Gavin Shaddick3, Rachel Charlton1, Julia Snowball1, Alison L Nightingale1, Catherine Smith4, William Tillet1,5 and Neil McHugh1,5, 1Department of Pharmacy and Pharmacology, The University of Bath, Bath, United Kingdom, QA
Background/Purpose: As psoriasis commonly precedes PsA, people with psoriasis provide an important population for studying the effect of modifiable risk factors in the development of PsA.
Results: The base population consisted of 90,189 incident cases of psoriasis (42% males, mean age 51), of which 1409 developed PsAafter the record of their psoriasis diagnosis:
Methods: Incident cases of psoriasis, diagnosed between 1998 and 2014, were identified from the UK Clinical Practice Research Datalink
