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Presentazione di PowerPoint - Dipartimento di Chimica e ... · Laboratorio di Chimica e Biologia di...

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Gruppo Prof. Anna Maria Papini e Prof. Paolo Rovero Unità di ricerca interdipartimentale Laboratorio di Chimica e Biologia di Peptidi e Proteine Email: [email protected], [email protected] www.peptlab.eu Purification of biomolecules , peptides, proteins Screening and biological characterization Autism Spectrum Disorders In Collaboration with: AUTOIMMUNE MEDIATE DISEASES Department of Pharmaceutical and Toxicological Chemistry, University of Naples ‘‘Federico II’’ (A. Carotenuto, E. Novellino) Department of Pharmaceutical Sciences, University of Salerno (AM. D’Ursi) Toscana Biomarkers Srl, Siena (MC. Alcaro) Istituto di Ricovero e Cura a Carattere Scientifico, Fondazione Santa Lucia, Neuroimmunology Unit (L Battistini, G Borsellino) Department of Neurological Sciences and Vision, University of Verona, Ospedale Policlinico (G.B. Rossi, B. Bonetti, L. Lovato) Laboratory of BioMolecules, UPMC- CNRS-ENS, Paris (F. Burlina, S Lavielle) Institut de Chimie Moleculaire (ICMUB, UMR CNRS 5260), University of Burgundy (S. Jugè) University of Milan Clinical Immunology, Humanitas Clinical and Research Center and University of California (C. Selmi) CNR ISTM, Padova (P.Traldi) University of Padova, Department of Sci. Med. & Chirurg. (A. Lapolla) Laboratory for Translational Research, Harvard Medical School and Department of Medicine, Brigham and Women’s Hospital, Boston (M. Chorev) Neurologie, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, and LINC, Université de Strasbourg-CNRS (J.de Seze and É. Trifilieff) MIT Massachusetts Institute of Technology (B. Imperiali) METABOLIC DISORDERS and AUTISM SPECTRUM DISORDERS Child Neuropsychiatry Unit, University Hospital AOUS of Siena (J. Hayke) Neonatal Intensive Care Unit, University Hospital AOUS of Siena (C. De Felice) Clinical Physiology Institute (IFC-CNR), National Research Council of Italy, Lecce Section, & Division of Neonatology, Perrino Hospital (Giuseppe Latini) Clinica Pediatrica e Dipartimento età evolutiva, University Hospital of Parma, Italy (S. Bernasconi, ME. Street) Bracco Foundation (E.Grossi) CULTURAL HERITAGE Chemistry Department University of Florence (L Dei, M.Potenza, L. Rosi) Earth Sciences Department University of Siena (A. Atrei, E. Gaggelli, I. Memmi, N. Marchettini, D. Valensin, G. Valensin) MOLECULAR STRUCTURES TO TARGETING TUMOR CELLS European Institute of Oncology Optimized strategies for the synthesis of bio molecules PeptLab Metabolic disorders This infrastructure is characterized by a strong know-how in organic and medicinal chemistry, in chemical biology, in synthesis as well as purification of small biomolecules, peptides, proteins and molecular and biological characterization Multi-disciplinary technology platform for research in life science Molecular structures to targeting tumor cells Microwave Synthesizer Explorer S Class (CEM) for organic synthesis Automated microwave peptide synthesizer Liberty (CEM) Multiple-Peptide Automatic Synthesizer APEX 396 (Advanced ChemTech) Ultra Fast HPLC + ESI-MS AktaBasic Liquid Chromatography System (GE Healthcare) for protein purification ACQUITY™ UPLC system (Waters) coupled with a Micromass® Q-Tof MICROTM mass spectrometer (Waters) equipped with an ESI source FACS per analisi di cellule Biacore T100 (GE Healthcare) EspiKem S.r.l. c/o Polo Scientifico Via Ugo Schiff n.6 Tel: 055 4573724 Fax: 055 4573584 e - mail: [email protected] ESPIKEM S.R.L. EspiKem Srl is a Contract Research Organization, founded in 2003 as a spin-off of the University of Florence, specialized in the field of design, synthesis, purification and characterization of peptides (also from natural sources) and their analogues of biomedical interest. TECHNOLOGY TRANSFER TOSCANA BIOMARKERS S.R.L. Toscana Biomarkers S.r.l. is a research and development company dedicated to the discovery and validation of new tests for diagnosis and follow-up of autoimmune diseases. Cultural Heritage Cosmeceutical peptides Autoimmune mediate diseases As a proof-of-concept we started organising two Research Units: PeptLab@UCP, a platform of the University of Cergy-Pontoise, located in the Laboratory of Chemical Biology EA4505 of the Department of Chemistry of the University of Cergy-Pontoise (France); PeptLab@Unifi, located in the Department of Chemistry "Ugo Schiff" and the Department NEUROFARBA (Department of Neurosciences, Psychology, Drug Research and Child Health) of the University of Florence (Italy)
Transcript
Page 1: Presentazione di PowerPoint - Dipartimento di Chimica e ... · Laboratorio di Chimica e Biologia di Peptidi e Proteine Email: annamaria.papini@unifi.it, paolo.rovero@unifi.it Purification

Gruppo Prof. Anna Maria Papini e Prof. Paolo Rovero

Unità di ricerca interdipartimentaleLaboratorio di Chimica e Biologia di Peptidi e Proteine

Email: [email protected], [email protected]

Purification of biomolecules, peptides,

proteins

Screening and

biological

characterization

Autism Spectrum

Disorders

In Collaboration with:

AUTOIMMUNE MEDIATE DISEASES

Department of Pharmaceutical and Toxicological Chemistry, University of Naples ‘‘Federico II’’ (A. Carotenuto, E. Novellino)Department of Pharmaceutical Sciences, University of Salerno (AM. D’Ursi)Toscana Biomarkers Srl, Siena (MC. Alcaro)Istituto di Ricovero e Cura a Carattere Scientifico, Fondazione Santa Lucia, Neuroimmunology Unit (L Battistini, G Borsellino)Department of Neurological Sciences and Vision, University of Verona, Ospedale Policlinico (G.B. Rossi, B. Bonetti, L. Lovato)Laboratory of BioMolecules, UPMC- CNRS-ENS, Paris (F. Burlina, S Lavielle)Institut de Chimie Moleculaire (ICMUB, UMR CNRS 5260), University of Burgundy (S. Jugè)University of Milan Clinical Immunology, Humanitas Clinical and Research Center and University of California (C. Selmi)CNR ISTM, Padova (P.Traldi)University of Padova, Department of Sci. Med. & Chirurg. (A. Lapolla)Laboratory for Translational Research, Harvard Medical School and Department of Medicine, Brigham and Women’s Hospital, Boston (M. Chorev)Neurologie, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, and LINC, Université de Strasbourg-CNRS (J.de Seze and É. Trifilieff)MIT Massachusetts Institute of Technology (B. Imperiali)

METABOLIC DISORDERS and AUTISM SPECTRUM DISORDERS

Child Neuropsychiatry Unit, University Hospital AOUS of Siena (J. Hayke)Neonatal Intensive Care Unit, University Hospital AOUS of Siena (C. De Felice)Clinical Physiology Institute (IFC-CNR), National Research Council of Italy, Lecce Section, & Division of Neonatology, Perrino Hospital (Giuseppe Latini)Clinica Pediatrica e Dipartimento età evolutiva, University Hospital of Parma, Italy (S. Bernasconi, ME. Street) Bracco Foundation (E.Grossi)

CULTURAL HERITAGE

Chemistry Department University of Florence (L Dei, M.Potenza, L. Rosi)Earth Sciences Department University of Siena (A. Atrei, E. Gaggelli, I. Memmi, N. Marchettini, D. Valensin, G. Valensin)

MOLECULAR STRUCTURES TO TARGETING TUMOR CELLSEuropean Institute of Oncology

Optimized strategies for the

synthesis of bio molecules

PeptLab

Metabolic

disorders

This infrastructure is characterized by a strong know-how in organic and medicinal chemistry, in

chemical biology, in synthesis as well as purification of small biomolecules, peptides, proteins and

molecular and biological characterization

Multi-disciplinary technology

platform for research in

life science

Molecular structures to

targeting tumor cells

Microwave Synthesizer Explorer S Class (CEM) for organic synthesis

Automated microwave peptide synthesizer Liberty (CEM)

Multiple-Peptide Automatic Synthesizer APEX 396 (Advanced

ChemTech)

Ultra Fast HPLC + ESI-MS

AktaBasic Liquid Chromatography System

(GE Healthcare) for protein purification

ACQUITY™ UPLC system (Waters) coupled with aMicromass® Q-Tof MICROTM mass spectrometer(Waters) equipped with an ESI source

FACS per analisi di cellule

Biacore T100 (GE Healthcare)

EspiKem S.r.l.

c/o Polo Scientifico

Via Ugo Schiff n.6

Tel: 055 4573724

Fax: 055 4573584

e-mail: [email protected]

ESPIKEM S.R.L.EspiKem Srl is a Contract Research Organization, founded in2003 as a spin-off of the University of Florence, specialized inthe field of design, synthesis, purification andcharacterization of peptides (also from natural sources) andtheir analogues of biomedical interest.

TECHNOLOGY TRANSFER

TOSCANA BIOMARKERS S.R.L.Toscana Biomarkers S.r.l. is aresearch and development companydedicated to the discovery andvalidation of new tests for diagnosisand follow-up of autoimmunediseases.

Cultural

Heritage

Cosmeceutical

peptides

Autoimmune

mediate

diseases

As a proof-of-concept we started organising two Research Units:PeptLab@UCP, a platform of the University of Cergy-Pontoise, located in the Laboratory of Chemical Biology EA4505 of the Department of

Chemistry of the University of Cergy-Pontoise (France);PeptLab@Unifi, located in the Department of Chemistry "Ugo Schiff" and the Department NEUROFARBA (Department of Neurosciences,

Psychology, Drug Research and Child Health) of the University of Florence (Italy)

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