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Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

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Treatment outcome according to tumor RAS mutation status in CRYSTAL study patients with metastatic colorectal cancer (mCRC) randomized to FOLFIRI with/without cetuximab. Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting. - PowerPoint PPT Presentation
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Treatment outcome according to tumor RAS mutation status in CRYSTAL study patients with metastatic colorectal cancer (mCRC) randomized to FOLFIRI with/without cetuximab Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting
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Page 1: Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Treatment outcome according to tumor RAS mutation status in CRYSTAL study patients with metastatic colorectal cancer (mCRC) randomized to FOLFIRI with/without cetuximab

Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Page 2: Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Disclosure Information<br />Relationships Relevant to this Session

Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Page 3: Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

CRYSTAL study design

Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Page 4: Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Background

Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Page 5: Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

RAS mutation analysis: BEAMing

Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Page 6: Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

RAS mutation analysis: BEAMing

Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Page 7: Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Study profile

Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Page 8: Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Other RAS mutations: CRYSTAL

Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Page 9: Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Other RAS mutations: first-line studies

Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Page 10: Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Comparison of RAS subgroups: <br />efficacy

Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Page 11: Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Baseline characteristics

Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Page 12: Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Efficacy: RAS subgroups

Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Page 13: Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Efficacy: RAS subgroups

Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Page 14: Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Progression-free survival

Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Page 15: Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Progression-free survival

Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Page 16: Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Overall survival

Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Page 17: Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Overall survival

Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Page 18: Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Efficacy: RAS subgroups

Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Page 19: Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Safety: grade 3/4 adverse events

Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Page 20: Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Conclusions

Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Page 21: Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

Acknowledgments

Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting


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