Principles of cleft lip and palate formation

Ahmed Abdulwahab (1330095)Firas Ahmed Saadallah(1330074)

• Genetics factor Chromosomal, Single gene,Multifactorial – oral clefts, Mitochondrial

• SyndromesTreacher Collins SyndromeHardikar syndromeFetal alcohol syndrome

• Environmental factors

Maternal smoking or tobacco exposureViral infectionsPoor nutritionCertain Medicinal drugsTeratogens like

PREDISPOSING FACTORS

High maternal age

Diabetes

Toxemia

Reduced blood supply

Folic acid deficiency

Radiations

FEEDING PROBLEMS

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