Pro activ with plant sterols

Becelpro.activwith plantsterols.Clinicallyprovento lowercholesterol.

Becel pro.activ HCP brochure 4_Layout 1 28/09/2011 15:12 Page 1

Contents

02 Introduction03 Diet and lifestyle play a key role

in reducing risk of cardiovasculardisease

04 International dietary guidelinesrecommend plant sterol

05 Plant sterols - occur naturally ineveryday foods

06 Plant sterols - proven dose-response reduction of LDLcholesterol

07 Plant sterols - reducingcholesterol absorption in the gut

08 Plant sterols - effective incombination with Statins

09 Plant sterols - effective acrosspopulations

10 Actively Lowering Cholesterol11 Optimum Intake of 2g/day12 Every day consumption of plant

sterols delivers sustained benefit13 Plant Sterols Safety14 A cost effective solution XXX15 Supporting Patient Compliance16 FAQs17 References18 Facts about Becel pro.activ foods


Globally, cardiovascular disease is the leading cause ofmorbidity and mortality, yet about 80% of heart disease andstroke could be prevented by positive lifestyle changes, such aseating a healthy diet, exercise and abstinence from smoking1.

Elevated LDL-cholesterol is widely accepted as one of the majormodifiable risk factors. Both lipid-lowering drugs as well as diethave been shown to be effective in reducing CHD risk.

There are many diet and lifestyle changes that may helpcontrol elevated LDL-cholesterol and therefore help in reducingthe risk of CHD. Dietary recommendations highlight the need tolower serum cholesterol and the important role that diet andlifestyle change must play. They include recommendations forthe use of specific foods with cholesterol-lowering benefitssuch as plant sterols. These additional options can enhance theeffectiveness of a typical healthy diet low in saturated fat andcontrolled in energy intake.

Becel pro.activ foods contain plant sterol in many humanstudies it has been shown that plant sterols significantly lowertotal and LDL-cholesterol.

Combined with other diet and lifestyle changes plant sterol-enriched foods can contribute to increasing the effectiveness ofdiet in lowering cholesterol and offer a valuable addition toreduce CHD risk.

This brochure contains information on plant sterols and Becelpro.activ for health care professionals.

0302

Elevated LDL-cholesterol is widely accepted as a key modifiablerisk factor for coronary heart disease (CHD), the main form ofCVD, yet more than half the population in most Westerncountries has cholesterol levels higher than desirable5.

Many dietary factors affect LDL-cholesterol levels. Makingpositive dietary changes including replacing saturated fats withpolyunsaturated fats and keeping intakes of trans fats to aminimum are well known to lower LDL-cholesterol6.

However, the single most effective way to lower LDL-cholesterol with dietary change7 is to include plant sterols orstanols. Eating 2-2.5 g of plant sterols daily can lower LDL-cholesterol by up to 15% when combined with the move to ahealthy diet and lifestyle†.

As heart disease has multiple risk factors, more than one mayneed to be improved to reduce the overall risk.

† Consumption of plant sterols in the range of 1.5-2.4g per day can lower LDL-cholesterol from 7-10% in2-3 weeks. The effect can be increased to 15% when combined with the move to a healthy diet andlifestyle.

Diet and lifestyle factors and their effect on LDL-cholesterol levels

* Calculated assuming a baseline LDL-cholesterol level of 3.5 mmol/L and assuming that 5 energy% from saturated fatty acids are replaced by anisocaloric amount of carbohydrates (Mensink et al, Am J Clin Nutr 2003)12 ** In case of overweight or obesity ***Calculated assuming a baselineLDL-cholesterol level of 3.5 mmol/L and assuming that 5 energy% from carbohydrates are replaced by an isocaloric amount of polyunsaturatedfatty acids (Mensink et al, Am J Clin Nutr 2003)12

Diet and lifestyle playa key role in reducingrisk of cardiovasculardisease Introduction

Approximate Recommendation

Component Dose or change reduction in in case of elevatedin intake/habit LDL-cholesterol LDL-C levels/increased

levels CVD risk

Plant sterols -2g per day -10% consume 2g per day

Saturated fatty acids -5% of total reduce intake to(SAFA) energy intake -5%* <7% of total energy(reduction in intake)

Dietary cholesterol Reduce intake to -5% reduce intake to(reduction in intake) <200mg a day <200mg a day

Body weight (loss)** -5 kg -5%** lose~10% body weight**

Viscous dietary 5-10g per day -5% increase intake tofibres 10g per day

PUFA +5% of total -3%*** consume up to 10%energy intake of total energy


There is a continuous dose-response relationship between theintake of plant sterols and their effect on LDL-cholesterollevels21,22. The more plant sterol consumed, the greater thereduction in LDL-cholesterol up to about 2-2.5g plant sterol perday. Intakes above 2.5g/day are not recommended as thisprovides little further benefit7.

The effect of plant sterols on LDL-cholesterol levels7

Since the late 1980s, Unilever, in collaboration with manyindependent scientific investigators, has extensively researchedthe cholesterol-lowering properties of plant sterols. There areover 40 clinical studies published in peer reviewed journals,proving the cholesterol-lowering efficacy of Becel pro.activfoods.

For more information about specific studies and products seewww.proactivscience.com [Insert new HCP website addresswhen launched]

Plant sterols should be consumed as part of a healthy diet.

plant sterols (grams per day)

0

-5

-10

-15

LDL-cholesterol low

ering

% re

duction

0.5 1 1.5 2 2.5 3 3.5

95% confidence interval

Plant sterols -proven dose-responsereduction of LDLcholesterol

The effects of plant sterols on cholesterol absorption

Without plant sterols With plant sterols

Plant sterols partially block the absorption of cholesterolfrom the gut, significantly lowering blood cholesterol levels

Plant sterols -reducing cholesterolabsorption in the gut

The key benefit of plant sterols lies in their ability to reduce theabsorption of cholesterol from the gut into the blood stream.Cholesterol is an essential building block in the human bodyand plays a key role in maintaining cell membranes. It isnaturally produced in the liver but is also delivered throughfoods containing cholesterol in the diet. As a part of normalmetabolism, cholesterol in the gut mixes with bile salts,lecithin and triglycerides to form micelles. Micelles then delivercholesterol to the cells lining the gut wall where the cholesterolis re-packaged and released into the bloodstream.

Plant sterols have a similar chemical structure to cholesterol. It

Cholesterol

More cholesterolabsorbed =

higher bloodcholesterol levels

Plant Sterols

Less cholesterolabsorbed =lower cholesterollevels

is thought that when plant sterols reach the gut they displacecholesterol from the micelles23. In this way, less cholesterolreaches the lining of the gut wall in a form that can beabsorbed.

Consuming 2g of plant sterols a day reduces the absorption ofcholesterol by 30-40%24. The cholesterol that is notincorporated into the micelles is then excreted (along withvirtually all the plant sterols). In this way, cholesterol isremoved from the body. Subsequently, levels of LDL cholesterolare lowered but HDL-cholesterol and triglyceride levels remainunaffected.

0504

Optimal Little furtherintake benefit


Plant sterols are found naturally in everyday foods likevegetable oils, nuts,seeds, grain products, fruit and vegetables.The average daily intake of plant sterols from regular foods isabout 0.3g per day. Western populations consume 0.15-0.31gplant sterols perday14,15,16. Diets that contain plant sterol-richfoods in abundance, such as vegetarian diets, provide 0.6gplant sterols per day17.

The optimal intake of plant sterols for significant cholesterollowering is 2-2.5g/day. To reach this recommended intake, verylarge quantities of regular foods would need to be consumed.

The quantity of regular foods required to provide2g plant sterols18,19,20

*where each individual item weighs 100g.

Plant sterols -occur naturally ineveryday foods

425tomatoes*

210carrots*

150apples*

83oranges*

70slices of

wholemealbread*

11cups of

peanuts*

2g plant sterols =

The optimum intake of plant sterols is 2-2.5g daily. This can beachieved by either eating three portions from a combination ofthe Becel pro.activ spreads, milk drink or yoghurt, or with the‘one-a-day’ yoghurt mini-drink (3 portions in one). Consumingmore than this doesn’t provide an additional cholesterol-lowering benefit.

For optimum benefit, Becel pro.activ foods should be consumedas part of a healthy diet and lifestyle.

It is recommended that plant sterols are consumed every dayfor continued cholesterol-lowering effects; if plant sterol-enriched foods are not consumed, the cholesterol-loweringeffect is lost.

Plant sterol-enriched foods significantly lower cholesterolwhether they are consumed once a day or over a number ofoccasions throughout the day. For maximum effect, Becelpro.activ foods should be consumed with a meal.

Optimum Intakeof 2g/day

0807

Continued use of Becel pro.activ

0%

10%Cholesterol reductio

n

TIME 3 weeks 6 weeksEach portion of becel pro.activ contains plant sterols to actively lowercholesterol. To get the best effect, continue eating the recommendedamount of Becel pro.activ everyday to keep your cholesterol level down.

stop using pro.activ

continueduse ofpro.activ


The International Atherosclerosis Society2, the US NationalCholesterol Education Program (NCEP), and many nationalorganisations including American Heart Association, HeartFoundation Australia, Dutch Heart Foundation, Finnish NutritionAssociation, Finnish Medical Society, Spanish AtherosclerosisSociety and Nutrition Foundation of Italy have all includedplant sterols in their dietary recommendations for cholesterolmanagement.

Both national and international dietary guidelines for theprevention of CHD now recommend the inclusion of 2g plantsterols per day for cholesterol lowering.

Plant sterols are natural components of a normal diet. Thesafety of consuming high intakes of plant sterols to lowercholesterol has been studied extensively since the 1950s andreviewed by independent experts and regulatory authoritiesinternationally.

In 2000, Becel pro.activ was the first spread to fully complywith the European Union Novel Foods legislation. It has beenapproved as safe by independent authorities in The EuropeanUnion, Norway, Switzerland, The United States, Australia, NewZealand, South Africa, Brazil, Israel, Iceland and Japan.

In 2004, the Becel range was extended following EuropeanUnion Novel Foods approval of plant sterol-enriched milk drink,yoghurt and ‘one-a-day’ yoghurt mini-drink.

Unilever’s continuing post-launch monitoring programmeconfirms that Becel pro.activ is being consumed by the correcttarget group and there is no evidence of over-consumption oradverse health effects34.

Consuming plant sterol-enriched foods could reduce healthcarecosts. Plant sterol-enriched foods significantly lowercholesterol and have the potential to provide substantialsavings in healthcare costs. Estimates based on the cost andoutcomes associated with suffering from a myocardialinfarction in the UK predicted annual savings of approximately£87 million / €130 million13.

International Atherosclerosis Society guidelinesfor prevention of heart disease

Internationaldietary guidelinesrecommend plantsterols Plant Sterols Safety

Therapeutic modifications towards a heart healthy diet

l reduce saturated fats to <7% of total energyl keep intakes of trans fatty acids lowl maintain intake of omega-3 fatty acids

- linolenic acid to at least 1% of total energy [2-3 g/day]- fish oil supplements for high risk patients optional

[EPA+DHA of 1 g/dayl reduce dietary cholesterol to <200 mg/dayl increase viscous fibre, if possible to 10 g/dayl consume at least 5 servings of fruits and vegetables dailyl ensure adequate intake of folic acid (400-1000 mg/day)l avoid excess intake of alcohol: no more than 20-30 g/day (men)

or 10-20 g/day (women)l consider adding plant stanol/sterols (2 g/day) for elevatedLDL-cholesterol

Ref: International Athersclerosis Society Executive BoardHarmonised Clinical Guidelines on Prevention of Athersclerosis Vascular disease, March 2003

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Plant sterol-enriched foods significantly lower cholesterol inpeople:• following both ‘typical’ and low fat diets• on lipid-lowering medications such as statins and fibrates• with elevated blood cholesterol levels• with type II diabetes• with familial hypercholesterolaemia

People with type II diabetes and familialhypercholesterolaemia (FH)

It has been shown that plant sterols lower LDL-cholesterollevels in people with type II diabetes28 and in children andadults with FH29.

Suitability of Becel pro.activ for specific dietaryneeds (adapt locally)

** contains artificial sweeteners: yoghurt contains sucralose and acesulfame K, and mini-drink containssucralose.

Plant sterols -effective acrosspopulations

Becel Spreads Milk ‘One-a-day’pro.activ (all drink Yoghurt yoghurt

suitable for: variants) mini-drink

Low fat diet Yes Yes Yes YesOvo-lacto

vegetarians Yes Yes Yes Yes

Vegans No No No NoDiabetic Diet Yes Yes Yes** Yes**

Dairy/milk free No No No No

Coeliac/gluten free Yes Yes Yes Yes

Lactoseintolerance No No No No

Nut free Yes Yes Yes YesHalal diet No No No No

Kosher diet No No No No

Plant sterols -effective incombinationwith Statins

Clinical evidence shows that eating plant sterol-enriched foods,in combination with statins, can have a greater cholesterol-lowering effect than statins alone1.

Cumulative benefits

A combination of statins, plant sterols and diet and lifestylechanges can work together to help patients achieve targets forcholesterol reduction3. They work in different ways andtherefore the effect of each is additive:

• Statins reduce LDL cholesterol levels by an average of 25%4. • Moving to a healthy diet and lifestyle can lower cholesterol by

5%; and • Including a plant sterol-enriched spread can help lower it by a

further 7-10%*

This combination of statins and plant sterols can lead to agreater reduction in cholesterol levels than doubling the statindose which has been shown to achieve just a 6% furtherreduction6.

Becel pro.activ may be a useful adjunct to statins and fibrates,offering additional cholesterol-lowering benefits27. However,dietary approaches should not be a substitute for lipid-loweringmedications and vice versa. If people are taking statins and/orfibrates and consuming plant sterol-enriched foods as part of aheart healthy diet, the dosage of medication may need to beadjusted.

% LD

L cho

lest

erol

low

erin

g

0

10

20

30

40

Scholle et al, 2009

Complementary cholesterol loweringeffects of plant sterols with statins

Statins

Diet and lifestyle

Plant Sterols

Statins

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Real People,Real Results

Supporting PatientCompliance

One of the biggest challenges facing any health interventionrequiring individual behaviour change is the waning ofindividual commitment and enthusiasm, leading to relapse.

The expert team behind Flora pro.activ recognise the need forongoing support for patients aiming to lower cholesterolthrough diet and lifestyle modifications. As well as a range ofpatient materials available to kick-start the intervention, wehave therefore launched a cutting-edge new consumer websitecommitted to giving inspiration and encouragement to stickwith a cholesterol-lowering regime, in a way that’s friendly andaccessible for consumers. Using real people’s stories as a basis,it makes it easier for your patients to see how they can make along-term change that’s good for their cholesterol. Visit ourpro.activ website to see inspiring stories, recipes, and exerciseand diet tips from people who have seen great results with florapro.activ.

A powerful clinical evidence base for plant sterols is thecornerstone for the becel pro.activ product range, but we allknow that it’s real results in the real world for your patientsthat count.

1000s of real people have successfully lowered theircholesterol with becel pro.activ, Their stories are available onthe becel website, as a source of inspiration for others who arelooking to make dietary changes to reduce cholesterol.

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What are plant sterols?Plant sterols are naturally occurring substances that are foundin everyday foods like fruits and vegetables, vegetable oils andnuts and grains. Plant sterols have a chemical structure similarto that of cholesterol. They play the same stabilising role inplant cell membranes as cholesterol does in our cells’membranes.

How do plant sterols lower cholesterol?Plant sterols partly block (inhibit) the absorption/uptake ofcholesterol from the gut. This results in a reduction in bloodLDL cholesterol with no effect on HDL cholesterol ortriglycerides.

What is the difference between plant sterols andplant stanols (found in Benecol)?Both have similar chemical structures and differ by only onechemical bond. Plant stanols are the hydrogenated form ofsterols, lacking the double bond. Plant sterols are naturallyoccurring substances that are found in everyday foods likefruits and vegetables, vegetable oils, nuts and grains. We useplant sterols extracted from vegetable oils, such as sunflowerseed, rape seed or soy bean and tall oil from pine trees.Independent clinical studies demonstrate that sterols andstanols are equally effective in terms of their cholesterol-lowering potential and play an important role in foodsproviding heart health benefits.

How safe are plant sterols?Plant sterols are safe – they are naturally occurring in the dietat low levels. To achieve substantial reduction in cholesterollevels we have increased the daily intake of plant sterols byaround five times. We are satisfied that they are safe at this

level too. Their safety has been supported by a large amount ofdata, including high dosage studies in different groups andlong-term studies which measured the key safety parameters.In addition, the safety of plant sterols has been reviewed bymany regulatory bodies around the world including theEuropean Union.

Are plant sterol enriched foods suitable forpregnant and breastfeeding women, and childrenunder five?Plant sterols are considered as safe cholesterol-loweringingredients. However, we do not recommend plant sterolenriched foods for children and breast-feeding or pregnantwomen, as these groups have specific nutritional needs andlowering cholesterol is not normally a priority for them. Thenutritional needs of children, breast-feeding or pregnantwomen are better met by regular Becel or regular milk andyoghurt.

How is pro.activ different from other Becelproducts?Becel pro.activ cholesterol products are specifically designedfor people who want to actively lower their LDL cholesterolthrough dietary change.

All Becel pro.activ cholesterol foods are enriched with plantsterols which are clinically proven to significantly lowercholesterol as part of a healthy diet and lifestyle.

Other products in the Becel range are not enriched with plantsterols and are not intended to actively lower cholesterol,rather they are designed to contribute to a heart healthy dietbecause they are high in polyunsaturated fat, significantlylower in saturated fat than butter and less than 1% trans fat.

FAQs

1 World Health Organisation (WHO). Diet, nutrition and the prevention of chronicdiseases. Report of a joint WHO/FAO Expert Consultation. WHO Technical Report Series916. Geneva, 2003.

2 International Atherosclerosis Society Executive Board, Harmonised Clinical Guidelineson Prevention of Atherosclerotic Vascular Disease. March 2003.

3 National Cholesterol Education Program. Executive summary of the third report of theNational Cholesterol Education Program (NCEP) expert panel on detection, evaluationand treatment of high blood cholesterol in adults (adult treatment panel III). JAMA2001; 285: 2486-2497.

4 Grundy SM, Cleeman JI, Merz CN, Brewer HB Jr, Clark LT, Hunninghake DB, Pasternak RC,Smith SC Jr, Stone NJ; for the Coordinating Committee of the National CholesterolEducation Program. Implication of recent clinical trials for the National CholesterolEducation Program Adult Treatment Panel III guidelines. Circulation 2004; 110: 227-239.

5 Tolonen H, Keil U, Ferrario M, Evans A. Prevalence, awareness and treatment ofhypercholesterolaemia in 32 populations: results from the WHO MONICA Project. Int JEpidemiol 2005; 34(1): 181-192.

6 Clarke R, Frost C, Collins R, Appleby P, Peto R. Dietary lipids and blood cholesterol:quantitative meta-analysis of metabolic ward studies. BMJ 1997; 314(7074): 112-117.

7 Katan MB, Grundy SM, Jones P, Law M, Miettinen T, Paoletti R; Stresa WorkshopParticipants. Efficacy and safety of plant stanols and sterols in the management ofblood cholesterol levels. Mayo Clin Proc 2003 Aug; 78(8): 965-978. Review.

8 Recommendations from the International Atherosclerosis Society, 2003, and NCEP ATPIII, Circulation, 2002 (except for soya protein: FDA recommendation, federal register,1999).

9 Federal Drug Administration. Food labelling: Health Claims; Soya Protein and Coronaryheart Disease; Final Rule. Federal register 1999; 64(206):57699-57733.

10 Jenkins DJA, Kendall CWC, Axelson M, Augustin LSA, Vuksan V. Viscous and nonviscousfibres, nonabsorbable and low glycaemic index carbohydrates, blood lipids andcoronary heart disease. Curr Opin Lipidol 2000;11:49-56.

11 Harland JI, Haffner TA. Systematic review, meta analysis and regression of randomizedcontrolled trials reporting an association between an intake of circa 25g soya proteinper day and blood cholesterol. Atherosclerosis 2008; doi:10.1016/j. atherosclerosis.2008/04.006.

12 Mensink RP, Zock PL, Kester ADM, Katan B. Effects of dietary fatty acids andcarbohydrates on the ratio of serum total to HDL-cholesterol and on serum lipids andapolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr 2003;77: 1146-55.

13 Phillips C, Belsey J, Schindler J. Flora pro.activ: a clinical and financial impact analysis. JMed Econ 2000; 3: 61-76.

14 Normen AL, Brants HA, Voorrips LE, Andersson HA, van den Brandt PA, Goldbohm RA.Plant sterol intakes and colorectal cancer risk in the Netherlands Cohort Study on Dietand Cancer. Am J Clin Nutr 2001;74(1):141-148.

15 Andersson SW, Skinner J, Ellegard L, Welch AA, Bingham S, Mulligan A, Andersson H,Khaw KT. Intake of dietary plant sterols is inversely related to serum cholesterolconcentration in men and women in the EPIC Norfolk population: a cross-sectionalstudy. Eur J Clin Nutr 2004;58(10):1378-1385.

16 Valsa LM, Lemstrom A, Ovaskainen ML, Lampi AM, Toivo J, Korhonen T, Piironen V.Estimation of plant sterol and cholesterol intake in Finland: quality of new values andtheir effect on intake. Br J Nutr 2004;92(4):671-678(8).

17 Vuoristo M, Miettinen TA. Absorption, metabolism, and serum concentrations ofcholesterol in vegetarians: effects of cholesterol feeding. Am J Clin Nutr1994;59(6):1325-1331.

18 Normen L, Johnsson M, Andersson H, van Gameran Y, Dutta P. Plant sterols invegetables and fruits commonly consumed in Sweden. Eur J Nutr 1999;38:84-89.

19 Normen L, Bryngelsson S, Johnsson M, Evheden P et al. They phytosterol content ofsome cereal foods commonly consumed in Sweden and in the Netherlands. J FoodComp Analysis 2002;15(6):693-704.

20 Weihrauch JL, Gardner JM. Sterol content of foods of plant origin. J Am Diet Assoc1978;73(1):39-47.

21 Law M. Plant sterol and stanol margarines and health. BMJ 2000;320:861-864.22 Hendriks HF, Weststrate JA, Van Vliet T, Meijer GW. Spreads enriched with three

different levels of vegetable oil sterols and the degree of cholesterol lowering innormocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr1999;53:319-327.

23 Trautwein EA, Duchateau GSMJE, Lin YG, Mel’nikov SM, Molhuizen HOF, Ntanios FY.Proposed mechanisms of cholesterol-lowering action of plant sterols. Eur J Lipid SciTech 2003; 105: 171-185.

24 Tikkanen MJ, Hogstrom P, Tuomilehto J et al. Effect of a diet based on low-fat foodsenriched with nonesterified plant sterols and mineral nutrients on serum cholesterol.Am J Cardiol 2001; 88:1157-1162.

25 Weststrate JA, Meijer GW. Plant sterol-enriched margarines and reductions in plasmatotal-and LDL-cholesterol concentrations in normocholesterolaemic and mildlyhypercholesterolaemic subjects. Eur J Clin Nutr 1998;52:334-343.

26 Maki KC, Davidson MH, Umporowicz DM, Schaefer EJ, Dicklin MR, Ingram KA, Chen S,McNamara JR, Gebhart BW, Ribaya-Mercado JD, Perrone G, Robins SJ, Franke WC. Lipidresponses to plant-sterol-enriched reduced-fat spreads incorporated into a NationalCholesterol Education Program Step I diet. Am J Clin Nutr 2001; 74: 33-43.

27 Simons LA. Additive effect of plant sterol-ester margarine and cerivastatin in loweringlow-density lipoprotein cholesterol in primary hypercholesterolemia. Am J Cardiol2002; 90:737-740.

28 Lee YM, Haastert B, Scherbaum W, Hauner H. A phytosterol-enriched spread improvesthe lipid profile of subjects with type 2 diabetes mellitus - a randomized controlledtrial under free-living conditions. Eur J Nutr 2003; 42(2): 111-117.

29 Amundsen Å &, Ntanios F, Put N V.d, Ose L. Long-term compliance and changes inplasma lipids, plant sterols and carotenoids in children and parents with FH consumingplant sterol ester-enriched spread. Eur J Clin Nutr 2004; 58(12): 1612-1620.

30 The research was carried out amongst women aged 16-64 years in France, Germany,Belgium and the UK. The research was conducted by TNS via Ncompass OnLineinternational omnibus from 17-20 April 2008. 2,119 interviews were carried out.

31 A healthy balanced diet is defined as one that is typically low in saturated fat, high infruit and vegetables and low in salt.

32 Consuming the optimal 2-2.5g of plant sterols daily typically lowers LDL cholesterol by10% – Katan MB, et al. Mayo Clin Proc 2003 Aug; 78(8): 965-978.

33 Assumes daily intake of three portions of Becel pro.activ foods e.g. two teaspoons ofBecel pro.activ spread, 250ml milk and one pot of yogurt, or, alternatively, one Becelpro.activ mini-drink.

34 Lea LJ and Hepburn PA. Safety evaluation of phytosterol-esters. Part 9:Results of aEuropean post-launch monitoring programme. Food Chem Toxicol 2006;44(18):1213-1222.

Facts about BecelReferences

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Becel pro.activ:Clinically provenin 45 studies

l Becel pro.activ is a range of everyday foods enriched withplant sterols

l Plant sterols lower cholesterol by partially blocking itsabsorption from the gut

l Over 40 clinical studies have proven the LDL-cholesterollowering effect of Becel pro.activ foods

l Advice to consume 2g of plant sterols per day is nowincluded in both international and national dietaryrecommendations for cholesterol management

l Several international health organisations recommend anoptimal daily intake of 2-2.5g plant sterols as part of ahealthy diet

l This can be achieved by consuming 3 portions of Becelpro.activ foods from spreads, milk drink and yoghurt oralternatively (3 portions in 1) with the ‘one-a-day’ yoghurtmini-drink

l Plant sterol-enriched foods have been developed for peoplewho want to actively lower their LDL-cholesterol throughhealthy diet and lifestyle

l Proven to be a safe and effective way to lower cholesterol,Becel pro.activ foods are available in more than 30 countriesworldwide

l Becel pro.activ may be suitable for people with elevatedcholesterol levels, as well as people already takingcholesterol lowering medication such as statins and fibrates,where they can be a useful addition

l Becel pro.activ may be suitable for people with type IIdiabetes and familial hypercholesterolaemia, but may benutritionally inappropriate for pregnant and breast-feedingwomen and children under five

For more information visit [insert new HCP website URL] August 2011

Facts about Becelpro.activ foods

1817


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Pro activ with plant sterols

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