Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies
for Biomedical Engineering and Environment Science
PT-BMES 2014
Date September 12-15 2014
Venue Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
No 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
Website httppt-bmeswebnodetw
1
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Contents
Contents 1
Preface 2
Information 3
Committee 4
List of Session Chairperson 5
List of Invited Speaker 6
Organizer 7
Co-Organizer 7
Map 8
Program 9
Invited Speaker 11
Poster Paper 45
Ministry of Science and Technology (MOST) paper 48
2
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Preface
The aim of Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering
and Environmental Sciences (PT-BMES) is to create starting points of collaborations between
Taiwanese and Japanese researchers on various fields of science and engineering for biomedical and
environmental technologies Through this symposium it is hoped that researchers from both sides
can co-develop new technologies to solve biomedical and environmental problems which have
definitely become the most important issues in both Taiwan and Japan societies Despite the
importance the development of the science and technologies contains a difficulty due to the needs of
interdisciplinary collaboration among multiple academic fields such as nanotechnology
biotechnology chemical engineering medical science pharmaceutical science etc Furthermore the
establishment of future collaborative works in advanced biomedical and environmental technologies
will be keystones for the scientific development of the entire Asia The symposia between them must
be fruitful for the development of the academic field in both Taiwan and Japan which contribute
greatly to the Asian societies This symposium co-organized by the Department of Biomedical
Engineering and Environmental Sciences National Tsing Hua University and the Department of
Materials Science and Technology Tokyo University of Science will be held on September 12
(Friday) to 15 (Monday) 2014 on the campus of the National Tsing Hua University at Hsinchu and
National Center of Traditional Art at I-Lan Taiwan
The objective of this symposium is the promotion of interdisciplinary research for biomedical
and environmental science and technologies both in Taiwan and Japan along with the
intercommunication among the graduate students of both countries to build a foundation stone for the
future collaboration among the scientists in Japan and Taiwan and all Asian countries in future
Representing the organizing committee members we thank to the keynote and invited speakers
and welcome all of the participants to join these symposia to promote fruitful tie-up of Asian
countries
PT-BMES 2014 Organizing Chairs
Prof Chi-Shiun Chiang Prof Kohei Soga
3
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Information
Date September 12-15 2014
Venue Department of Biomedical Engineering and Environmental Sciences National Tsing
Hua University No 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
Website httppt-bmeswebnodetw
Notice for Presenting Authors The full poster abstract download will be available on Sept
12th 2014 on symposium website The attendee are recommended to download the PDF file to
your computer or your pad device
ABSTRACT SUBMISSION
Poster sessions
bull Session A Biomaterials
bull Session B Biomedical Imaging
bull Session C Science and Technology for Environment amp Energy
4
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Committee
Organizing Chair Prof Chi-Shiun Chiang Chairman BMES NTHU Taiwan
Organizing Co-Chair Prof Kohei SOGA PTRC TUS Japan
Symposium Secretariat Prof Shang-Hsiu Hu BMES NTHU Taiwan
Local Organizing Committee Prof Ruey-An Doong NTHU Taiwan
Prof Hsin-Cheng Chiu NTHU Taiwan
Prof Chih-Kuang Yeh NTHU Taiwan
Prof Yu-Fen Huang NTHU Taiwan
Dr Wen-Hsuan Chiang NTHU Taiwan
Prof Tzu-Wei Wang NTHU Taiwan
Prof Chien-Wen Chang NTHU Taiwan
Prof Yuh-Chang Sun NTHU Taiwan
Prof Fu-Nien Wang NTHU Taiwan
Prof Hsu-Hsia Peng NTHU Taiwan
Contact Prof Shang-Hsiu Hu NTHU Taiwan
Email address shhumxnthuedutw
5
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
List of Session Chairperson
Session A Biomaterials Prof Ryo Ishihara (石原量 ) (Professor Dept of Materials Science and Technology Tokyo
University of Science Japan)
Prof Hsin-Cheng Chiu (邱信程) (Professor Dept of Biomedical Engineering and Environmental
Sciences National Tsing Hua University)
Session B Biomedical Imaging Prof Chih-Kuang Yeh (葉秩光) (Professor Dept of Biomedical Engineering and Environmental
Sciences National Tsing Hua University)
Prof Kohei Soga (曽我公平) (Professor Dept of Materials Science and Technology Tokyo
University of Science Japan)
Session C Science and Technology for Environment amp Energy Prof Yu-Fen Huang (黃郁棻) (Professor Dept of Biomedical Engineering and Environmental
Sciences National Tsing Hua University)
Prof Keishi Nishio ( 西 尾 圭 史 ) (Professor Dept of Materials Science and Technology
University of Tsukuba)
6
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
List of Invited Speaker
Session A Biomaterials Prof Yung Chang (張雍) (Professor Dept of Chemical Engineering Chung Yuan University)
Prof Yutaka Ikeda (池田豊) (Professor Dept of Mater Sci University of Tsukuba Japan)
Prof Tzu-Wei Wang (王子威) (Professor Dept of Materials Science and Engineering National
Tsing Hua University)
Prof Ryo Ishihara (石原量) (Assistant Professor Dept of Materials Science and Technology
University of Tsukuba Japan)
Dr Wen-Hsuan Chiang (姜文軒) (Assistant Researcher Dept of Biomedical Engineering and
Environmental Sciences National Tsing Hua University)
Session B Biomedical Imaging Prof Hao-Li Liu (劉浩澧) (Dept of Electrical Engineering Chang Gung University Taiwan)
Dr Ichio Aoki (青木伊知男) (Molecular Imagining Center National Institute of Radiological
Sciences Japan)
Prof Meng-Lin Li (李夢麟) (Associate Professor Dept of Electrical Engineering National Tsing
Hua University)
Prof Tomoko Masaike (政池知子) (Associate Professor Tokyo University of Science Japan)
Prof Chih-Chung Huang(黃執中 ) (Assistant Professor Dept of Biomedical Engineering
National Cheng Kung University)
Prof Masao Kamimura ( 上村真生 ) (Assistant Professor Dept of Materials Science and
Technology University of Tsukuba Japan)
Session C Science and Technology for Environment amp Energy Prof Keishi Nishio (西尾圭史 ) (Professor Dept of Materials Science and Technology
University of Tsukuba)
Prof Hsing-Cheng Hsi (席行正) (Associate Professor Graduate Institute of Environmental
Engineering National Taiwan University)
Prof Kenjiro Fujimoto(藤本憲次郎 )(Department of Pure and Applied Chemistry Tokyo
University of Science)
Prof Fu-Hsiang Ko (柯富祥) (Professor Institute of Nanotechnology National Chiao Tung
University)
Prof Naoto Kitamura (北村尚斗 ) (Associate Professor Department of Pure and Applied
Chemistry Tokyo University of Science)
Prof Zong-Hong Lin (林宗宏 ) (Assistant Professor Institute of Biomedical Engineering
National Tsing Hua University)
7
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Organizer
Department of Biomedical Engineering and Environmental Sciences (BMES)
National Tsing HuaUniversity (NTHU) Taiwan
清華大學 生醫工程與環境科學系
Department of Materials Science and Technologies
Tokyo University of Science (TUS) Japan
東京理科大學 材料科學與技術系
Co-Organizer
Engineering and Technology Promotion Center
National Science Council (NSC) Taiwan
國家科學委員會 工程科技推展中心
College of Nuclear Science
National Tsing Hua Univeristy (NTHU) Taiwan
清華大學 原子科學院
8
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Map
9
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Program
September 12 (Fri) 2014
Time Agenda Speaker
1900~2100 Welcome and Opening Ceremony (Hall of Fame)
September 13 (Sat) 2014 Place NTHU BMES
Time Agenda Speaker
0830~0900 Registration (Entrance Hall NTHU BMES)
0900~0915 Opening Remarks Symposium Chairs
Session A Biomaterials Moderator Hsin-Cheng Chiu (NTHU) Ryo Ishihara (TUS)
0915~0945 Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes (Keynote)
Prof Yung Chang張
雍
0945~1015 Chemical Modifications for the Developments of Next Generation
Drugs (Keynote)
Prof Yutaka Ikeda
池田豊
1015~1045 Electrospun Composite Nanofibers with Staged Release of Multiple
Angiogenic Growth Factors for Chronic Wound Healing (Keynote)
Prof Tzu-Wei Wang
王子威
1045~1110 Break
1110~1140 Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip
toward Point-of-Care Diagnosis (invited)
Prof Ryo Ishihara石
原量
1140~1210 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and
Imaging Applications (Invited)
Dr Wen-Hsuan
Chiang姜文軒
1200~1330 Lunch
Session B Biomedical Imaging Moderator Chih-Kuang Yeh (NTHU) Kohei Soga (TUS)
1320~1400 Focused-Ultrasound Brain-Drug Delivery Approach and
Application (Keynote)
Prof Hao-Li Liu劉
浩澧
1400~1440 Responsive and Theranostic Nano-Contrast Agents for Preclinical
MR Imaging (Keynote)
Dr Ichio Aoki青木
伊知男
1440~1510 Observation of Single-Molecule Enzymes through Probes under the
Optical Microscope (Keynote)
Prof Tomoko
Masaike政池知子
1510~1630 Break
1630~1710 Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing
SPIO Nanoparticles Ultrasonically (Invited)
Prof Meng-Lin Li
李夢麟
1710~1740 High resolution ultrasound elastography for medical applications
(Invited)
Prof Chih-Chung
Huang黃執中
1740~1810 Biofunctional Polymers for Application of Ceramic Nanoparticles
for Fluorescence Bioimaging (Invited)
Prof Masao
Kamimura上村真生
1900~ Banquet (合口味)
10
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
September 14 (Sun) 2014 Place NTHU BMES
Time Agenda Speaker
0845~0900 Registration
Session C Science and Technology for Environment amp Energy
Moderator Yu-Fen Huang (NTHU) Keishi Nishio (TUS)
0900~0930 Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed
Tungsten Oxide Thin Films for Hydrogen Gas Sensor (Keynote)
Prof Keishi Nishio
西尾圭史
0930~1000 Control of low-concentration gaseous mercury from stationary
sources via adsorption and oxidation (Keynote)
Prof Hsing-Cheng
His席行正
1000~1030 High-Throughput Functional Materials Exploration by
Combinatorial WetDry Process (Keynote)
Prof Kenjiro
Fujimoto藤本憲次
郎
1030~1050 Break
1050~1120 Facile Manufacturing on Energy-efficient Devices with Flexibility
and Antireflection (Invited)
Prof Fu-Hsiang Ko
柯富祥
1120~1150 Proton Distribution and Dynamics in BaZrO3-Based Proton
Conductor for Solid Oxide Fuel Cell (Invited)
Prof Naoto
Kitamura北村尚斗
1150~1220 Harvesting Water Energy by a Sequential Contact-Electrification and
Electrostatic-Induction Process (Invited)
Prof Zong-Hong
Lin林宗宏
1210~1330 Lunch
Poster Session
1330~1530 Poster Session
1600~1800 Move to I-Lan
1800~2000 Luodong Night Market
2000 National Center for Traditional Art I-Lan (宜蘭傳藝)
September 15 (Mon) 2014 Place I-Lan
Time Agenda Speaker
0700~0800 Breakfast
0845~0910 Closing Remarks
(National Center for Traditional Art I-Lan)
0910~1500 Visit National Center for Traditional Art
1150~1330 Lunch
1530 Move to Taipei Railway Station or Hsinchu
11
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker
Invited Speaker A-1 Prof Yung Chang
Distinguished Professor
Department of Chemical Engineering
Deputy Director RampD Center for Membrane Technology
Chung Yuan Christian University
Address Jhong-Li Taoyuan 320 Taiwan
TEL (886) 265-4122
FAX (886) 265-4190
Education 2004 PhD Chemical Engineering National Taiwan University Taiwan 2000 MS Chemical Engineering National Taiwan University Taiwan 1998 BS Chemical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013-present Deputy Director RampD Center for Membrane Technology Chung Yuan Christian
University 2013-present Distinguished Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2013-present Professor Department of Chemical Engineering Chung Yuan Christian University
Taiwan 2009-2013 Associate Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2006-2009 Assistant Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2005-2006 Postdoctoral Fellow Chemical Engineering University of Washington USA 2004-2005 Postdoctoral Fellow Chemical Engineering National Taiwan University Taiwan
Honor and awards (2010~) 2010 Yung Investigator Award of Chemical Engineering (Taiwan Institute of Chemical Engineers) 2010 Yung Investigator Award of Materials on Regenerative Medicine (National Health Research
Institutes Taiwan) 2011 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan) 2011 Outstanding Research Award of Chemical Engineering (LCY Chemical Corp) 2012 NSC Wu Da-Yu Award (National science council Taiwan) 2012 NSC Outstanding AcademicIndustrial Cooperation Award (National science council) 2013 Yung Investigator Award of Polymer Science (Taiwan Institute of Polymer Science) 2013 JCS The Distinguished Lectureship Award Biomaterial Research (Japan Chemical Society) 2013 Ukraine International Invention Exhibition Gold Medal (Ukraine Invention Society) 2014 Pittsburgh International Invention Exhibition Gold Medal (USA Invention Society) 2014 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan)
12
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-1 Sep 13 2014 (Sat) 0915-0945 at NTHU BMES R120
Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes
Chung Yuan
RampD Center for Membrane Technology and Department of Chemical Engineering Christian
University Chung-Li Taoyuan 320 Taiwan
Zwitterionic polymeric interface resisting the adsorption of plasma proteins is important in the
development of blood-contacting biomaterials in such applications as blood collection devices
antithrombogenic implants hemodialysis membranes drug-delivery carriers and diagnostic
biosensors Previous studies showed that the control of surface charge neutrality is important for a
zwitterionic surface with effective protein-resistant properties Importantly it was further reported
that the mixed-charge formulation in self-assembled monolayers copolymer hydrogels and
polymeric brushes provide a new avenue to achieve nonfouling surfaces with the prevention of
nonspecific protein adsorption if the charge balance can be well controlled This talk will cover three
major studies
Bio-inert nature of biomimetic zwitterionicpseudozwitterionic structures
Blood-Inert
Surfaces via ion-pair anchoring of zwitterionic copolymer brushes in human whole blood Surface
zwitterionization of membrenaes in novel biomedical applications
[1] Chang Y Liao SC Higuchi A Ruaan RC Chu CW Chen WY A highly stable nonbiofouling surface with
well-packed grafted zwitterionic polysulfobetaine for plasma protein repulsion Langmuir 2008245453-58
[2] Chiag YC Chang Y Higuchi A Chen WY Ruaan RC Sulfobetaine-grafted poly(vinylidene fluroride) ultrafiltration
membranes exhibit excellent antifouling property Journal of Membrane Science 2009339151-9
[3] Chang Y Yandi W Chen WY Shih YJ Yang CC Chang Y Ling QD Higuchi A Tunable bioadhesive copolymer
hydrogels of thermoresponsive poly(N-isopropyl acrylamide) containing zwitterionic polysulfobetaine
Biomacromolecules 2010111101-10
[4] Chang Y Chang WJ Shih YJ Wei TC Hsiue GH Zwitterionic sulfobetaine-grafted poly(vinylidene fluoride)
membrane with improved blood compatibility via atmospheric plasma-induced surface copolymerization ACS Appl
Mater Interfaces 201131228-37
[5] Shih YJ Chang Y Deratani A Damien Q Schizophrenic hemocompatible copolymers via switchable
thermoresponsive transition of nonioniczwitterionic block self-assembly in human blood Biomacromolecules
2012132849minus58
[6] Chang Y Shih YJ Lai CJ Kung HH Jiang S Ion-pair anchoring of self-assembled zwitterionic copolymer surfaces
with highly controlled blood compatibility Advanced Functional Materials 2013231100-10
13
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-2 Dr Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences
University of Tsukuba
Address Tennoudai 1-1-1 Tsukuba Ibaraki 305-8573 Japan
E-mailikedaimstsukubaacjp
Education March 1999 B S in Faculty of Engineering Kyoto University March 2001 MS in Graduate School of Engineering Department of Synthetic Chemistry and
Biological Chemistry Kyoto University March 2004 PhD in School of Engineering The University of Tokyo
Professional Experience 2004~2006 Advanced industrial science and technology (AIST) 2006~2008 Cytopathfinder Inc 2008~to date University of Tsukuba
Selected Publication (2010~) Y Ikeda J Katamachi H Kawasaki Y Nagasaki Novel protein PEGylation chemistry via glutalaldehydefunctionalized PEG Bioconjugate Chemistry 24 1824-1827 (2013) Y Ikeda D Kubota Y Nagasaki Design of sugar-oligonucleotide conjugates installed gold nanoparticle for effective delivery to hepatic parenchymal cells Colloid and Polymer Science 291 2959-2964 Y Ikeda H Kawasaki S Ichinohe Y Nagasaki Facile solid-phase synthesis of a highly stable poly(ethylene glycol)-oligonucleotide conjugate Journal of Materials Chemistry B 1 529-535(2013) Y Ikeda T Jomura U Horiuchi J Saeki K Yoshimoto T Ikeya Y Nagasaki Long-term survival and functional maintenance of hepatocytes by using a microfabricated cell array Colloid and Surface B Biointerface 97 97-100 2012 Y Ikeda Y Nagasaki PEGylation Technology in Nanomedicine Advances in Polymer Science 247 115-140 2012 Y Ikeda R Suzuki T Yoshitomi Y Nagasaki Novel oligonucleotide carrier possessing reactive oxygen species scavenging ability Macromolecular Bioscience 2011 11 344-351 Y Ikeda D Kubota Y Nagasaki Simple solid-phase synthesis and biological properties of carbohydrate-oligonucleotide conjugates modified at the 3rsquo terminus Bioconjugate Chem 2010 21 1685-1690
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Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-2 Sep 13 2014 (Sat) 0945-1015 at NTHU BMES R120
Chemical Modifications for the Developments of Next Generation Drugs
Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences University of
Tsukuba
Controlling of biodistribution and PKPD is a key issue for the development of drugsVariety of
technologies have been reported to improve those properties Those technologies include
nanoparticle formulation and PEGylation technology In my presentation I will show recent
chemical modification technologies which we developed to improve PKPD and distribution of
drugs
A novel chemistry for the PEGylated protein with a high activity
Several PEGylated proteins have been approved as therapeutic drugs In many cases PEGylated
protein has been synthesized by the conjugation reaction between PEG possessing activated ester and
amine(s) in the protein This reaction however often causes inactivation of PEGylated proteins In
this report we present a novel chemistry which enables the PEGylation of proteins under the mild
reaction condition PEGylated lysozyme prepared by the method developed increased the biological
activity of the PEGylated lysozyme more than 20 times compared with the PEGylated lysozyme
prepared by the conventional method
Design and development of novel hypoxically activated prodrugs
Tumor hypoxia is well known to promote mutagenesis invasiveness and to be associated with a
worse prognosis Although the treatment of the tumor hypoxia has been highly demanded resistance
to radiotherapy and anticancer chemotherapy have been serious problems The object of this study
was the development of hypoxically activated prodrugs which accumulate and act on cells at hypoxic
region of tumor Several conventional anti-cancer drugs including doxorubicin gemcitabine and 5FU
have been modified with 2-nitro imidazole derivative This modification enabled inactivation of drug
to reduce adverse effects under the normoxia condition and selective activation of prodrug under the
hypoxic condition
15
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-3 Prof Tzu-Wei Wang
Associate Professor
Department of Materials Science and Engineering and Institute of Biomedical
Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013
Office Delta Teaching Building R434
TEL +886-3-5715131 ext 33856
Email twwangmxnthuedutw Education 2006 PhD Institute of Biomedical Engineering National Taiwan University Taiwan
Professional Experience 2013 ndashpresent Associate Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2009 -2013 Assistant Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2007-2009 Postdoctoral Research Fellow Tissue Engineering Laboratories of Brigham and Womenrsquos
Hospital Harvard Medical School USA
Honor and awards (2009~) Young Plenary Award 2013 TERMIS-AP Symposium Shanghai China (2013) The 9th National Innovation Award Academic Research Category by Institute for Biotechnology and Medicine Industry Taiwan (2012) Young Investigator Award International Symposium of Materials on Regenerative Medicine Taiwan (2012 ISOMRM) Young Investigator Award 5th World Congress on Bioengineering the World Association for Chinese Biomedical Engineers Taiwan (WACBE 2011)
Selected Publication (2012~) Yang CS Wu HC Sun JS Hsiao HM Wang TW Thermo-induced shape memory PEG-PCL copolymer as dual drug-eluting biodegradable stent ACS Appl Mater Interfaces 2013 5 (21) 10985ndash10994 Yeh PH Sun JS Wu HC Hwang LH Wang TW Stimuli-responsive HA-PEI nanoparticles encapsulating endostatin plasmid for stem cell gene therapy RSC Advances 2013 3 (31) 12922 - 12932 Chen YY Wu HC Sun JS Dong GC Wang TW Injectable and thermoresponsive self-assembled nanocomposite hydrogel for long-term anticancer drug delivery Langmuir 201329(11)3721-3729 Cheng TY Wu HC Chang WH Huang MY Lee CH Wang TW Self-assembling functionalized nanopeptides for immediate hemostasis and accelerative liver tissue regeneration Nanoscale 2013 5 (7) 2734 - 2744 Chang YJ Tsai CJ Tseng FG Chen TJ Wang TW Micropatterned Stretching System for the Investigation of Mechanical Tension on Neural Stem Cells Behavior Nanomedicine Nanotechnology Biology and Medicine 20139345-355 Cheng TY Chen MH Chang WH Huang MY Wang TW Neural stem cells encapsulated in a functionalized self-assembling peptide hydrogel for brain tissue engineering Biomaterials 2013 34(8)2005-2016 Goh JH Wu HC Chen MH Chen MY Chang SC Wang TW Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages Acta Biomaterialia 20139(2)5170-5180 Huang YJ Wu HC Tai NH Wang TW Carbon Nanotube Rope with Electrical Stimulation Promotes the Differentiation and Maturity of Neural Stem Cells Small 20128(18) 2869ndash2877
16
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-3 Sep 13 2014 (Sat) 1015-1045 at NTHU BMES R120
Electrospun Composite Nanofibers with Staged Release of Multiple Angiogenic Growth Factors for Chronic Wound Healing
Tzu-Wei Wang
Department of Materials Science and Engineering and Institute of Biomedical Engineering National
Tsing Hua University
The objective of this research study is to develop collagen (Col) and hyaluronic acid (HA)
inter-stacking nanofibrous skin equivalent substitute with programmable release of multiple
angiogenic growth factors (VEGF PDGF bFGF and EGF) either directly embedded in the
nanofibers or encapsulated in the gelatin nanoparticles (GN) by electrospinning technology The
delivery of EGF and bFGF in early stage is expected to accelerate epithelialization and vasculature
sprouting while release of PDGF and VEGF in late stage is aimed for the induction of blood vessels
maturation The physiochemical characterizations report that the Col-HA-GN nanofibrous membrane
possesses mechanical property similar to human native skin The design of particle-in-fiber structure
allows growth factors for slow controlled release up to one month Cultured on biodegradable
Col-HA membrane with four kinds of growth factors (Col-HA w4GF) endothelial cells not only
increase in growth rate but also form better network of thread-like tubular structure Therapeutic
effect of Col-HA w4GF membrane on STZ-induced diabetic rats reveal accelerated wound closure
rate elevated collagen deposition and enhanced mature vessels by Massonrsquos trichrome stain and
immunohistochemical analysis respectively From the above the electrospun Col-HA-GN composite
nanofibrous skin substitute with stage-wise release pattern of multiple angiogenic factors could be a
promising bioengineered construct for the chronic wound healing in skin tissue regeneration
17
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-4 Assistant Prof Ryo Ishihara
Assistant Professor
Department of Materials Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
Tokyo University of Science Research Building 9th floor
TEL +81-3-5876-1415
FAX +81-3-5876-1415
Education 2012 PhD Department of Applied Chemistry and Biotechnology Chiba University Japan 2008 MS Department of Materials Technology Chiba University Japan 2006 BS Department of Materials Technology Chiba University Japan
Professional Experience 2014 ndashpresent Assistant Professor Department of Materials Science and Technology Tokyo
University of Science 2012 ndash2014 Postdoctral Researcher Bioengineering Laboratory RIKEN
Honor and awards Department chairmanlsquos award from Chiba University (2012)
Selected Publication (2010~) Simple Method for High-Density Impregnation of Aliquat 336 onto Porous Sheet and Binding Performance of Resulting Sheet for Palladium Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota Sep Sci Technol 49154-159 (2014) Effect of Dose on Mole Percentage of Polymer Brush and Root Grafted onto Porous Polyethylene Sheet by Radiation-Induced Graft Polymerization R Ishihara S Uchiyama H Ikezawa S Yamada H Hirota D Umeno K Saito Ind Eng Chem Res 5212582-12586 (2013) Determination of Mole Percentages of Brush and Root of Polymer Chain Grafted onto Porous Sheet S Uchiyama R Ishihara D Umeno K Saito S Yamada H Hirota S Asai J Chem Eng Japan 46414-419 (2013) Crosslinked-chelating Porous Sheet with High Dynamic Binding Capacity of Metal Ions G Wada R Ishihara K Miyoshi D Umeno K Saito S Yamada H Hirota Solv Extr Ion Exch 31210-220 (2013) Dependence of Lanthanide-Ion Binding Performance on HDEHP Concentration in HDEHP Impregnation to Porous Sheet R Ishihara S Asai S Otosaka S Yamada H Hirota K Miyoshi D Umeno K Saito Solv Extr Ion Exch 30171-180 (2012) Impregnation of TOPO onto Hydrophobic-Ligand-Containing Porous Sheet and Its Adsorptionelution Performance of Bismuth Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota React Funct Polym 70986-990 (2010)
18
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-4 Sep 13 2014 (Sat) 1110-1140 at NTHU BMES R120
Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip toward Point-of-Care Diagnosis
Ryo Ishihara Kazuo Hosokawa Mizuo Maeda
Bioengineering Laboratory RIKEN
MicroRNAs (miRNAs) are short and non-protein-coding single-stranded RNAs and have shown great promise for
cancer diagnosis Some miRNAs circulate in human body fluid with extremely low concentrations and its expression
profiling can detect and classify cancers in the human body [1] Point-of-care (POC) diagnosis requires short detection
time small required sample volume and portability of the device In various miRNA detection methods microfluidic
chip meets the requirements except the portability Hence we used our power-free pump-free microfluidic chip driven
by energy that is stored in degased PDMS to overcome those drawbacks which eliminates the need for external power
sources for fluid pumping [2] The pump-free pumping method is essential for microfluidic chip-based POC diagnosis In
our laboratory rapid and sensitive singleplex miRNA detection with laminar flow-assisted dendritic amplification (LFDA)
[3] on the pump-free microfluidic chip has been developed [4] In this study rapid and sensitive multiplex miRNA
detection on the pump-free microfluidic chip was demonstrated
Pump-free microchip for multiplex miRNA detection was prepared as follows First the PDMS part with a pair of
Y-shaped microchannels with 100 μm in width and 25 μm in height was fabricated Second three parallel-line-shaped
probe DNAs were patterned onto a glass surface Third the PDMS channels were attached onto the glass plate Finally
the chip was degassed in a vacuum chamber After the chip preparation target miRNAs were detected following three
steps (1) blocking (2) sandwich hybridization of the target miRNAs and biotinylated probe DNAs and (3) signal
amplification by LFDA MiR-16 miR-21-5p and miR-500a-3p were used as target miRNAs since they are known as
cancer biomarkers [5-7] Fluorescence signals were captured by CCD camera and analyzed by the software (ImageJ)
Bright lines appeared at the expected positions they appeared only on the areas with the respective probe DNA in which
the target miRNAs had been supplied These data prove that the LFDA successfully took place in a target
sequence-dependent manner Calibration curves were plotted from the fluorescence signals The data points of the
calibration curve were fitted with the four-parameter logistic function and limit-of-detections (LODs) were evaluated by
the 3σ criterion LODs of the miR-16 miR-21-5p and miR-500a-3p were 68 fM 15 pM and 150 fM respectively The
LODs are on the same order of magnitude as concentrations of miRNA in blood Multiplex detection was verified from
correspondence between the calibration curves of single and multiplex The required sample volume was 05 microL and
assay time was 20 min Because most of the existing methods take more than a few hours the rapidness small required
sample volume and portability of the device are ideal advantages for POC diagnosis
References
[1] PS Mitchell et al PNAS 105 (2008) 10513 [2] K Hosokawa et al Lab Chip 4 (2004) 181 [3] K Hosokawa et al Anal
Chem 79 (2007) 6000 [4] H Arata et al PLoS ONE 7 (2012) e48329 [5] MJ Lodes et al PLoS ONE 4 (2009) e6229
[6] Y Toiyama et al J Natl Cancer Inst 105 (2013) 849 [7] Y Yamamoto et al Biomarkers 14 (2009) 529
19
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-5 Dr Wen-Hsuan Chiang
Assistant Researcher
Department of Biomedical Engineering and Environmental Sciences
National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
TEL (886) 3-571-5131 ext 35576
Education 2009 PhD Department of Chemical Engineering National Chung Hsing University Taiwan Thesis Supervisor Professor Hsin-Cheng Chiu 2002 BS Department of Chemical Engineering Tatung University Taiwan Professional Experience 2013 ndashpresent Assistant Researcher Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University 2010 ndash2012 Postdoctoral Fellow Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
Areas of Research Expertise Biomaterials Smart Amphiphilic Copolymers Multifunctional Nanocarriers for Cancer Therapy and Imaging Nano Science and Interfacial Engineering
Selected Publication (2010~) Wen-Hsuan Chiang Wen-Chia Huang Ming-Yin Shen Che-Hsu Wang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Dual-Layered Nanogel-Coated Hollow LipidPolypeptide Conjugate Assemblies for Potential pH-Triggered Intracellular Drug Release PLOS ONE 2014 9 1-11 Wen-Hsuan Chiang Wen-Chia Huang Chien-Wen Chang Ming-Yin Shen Zong-Fu Shih Yi-Fong Huang Sung-Chyr Lin Hsin-Cheng Chiu Functionalized Polymersomes with Outlayered Polyelectrolyte Gels for Potential Tumor-Targeted Delivery of Multimodal Therapies and MR Imaging Journal of Controlled Release 2013 168 280-288 Wen-Hsuan Chiang Viet Thang Ho Hsin-Hung Chen Wen-Chia Huang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Superparamagnetic Hollow Hybrid Nanogels as a Potential Guidable Vehicle System of Stimuli-Mediated MR Imaging and Multiple Cancer Therapeutics Langmuir 2013 29 6434-6443 Wen-Hsuan Chiang Viet Thang Ho Wen-Chia Huang Yi-Fong Huang Chorng-Shyan Chern Hsin-Cheng Chiu Dual Stimuli-Responsive Polymeric Hollow Nanogels Designed as Carriers for Intracellular Triggered Drug Release Langmuir 2012 28 15056-15064 Yi-Fong HuangDagger Wen-Hsuan ChiangDagger Pei-Ling Tsai Chorng-Shyan Chern Hsin-Cheng Chiu Novel Hybrid Vesicles Co-Assembled from Cationic Lipid and PAAc-g-mPEG with pH-Triggered Transmembrane Channels for Controlled Drug Release Chemical Communications 2011 47 10978-10980
20
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-5 Sep 13 2014 (Sat) 1140-1210 at NTHU BMES R120 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and Imaging
Applications
Wen-Hsuan Chiang
Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
In order to promote therapeutic efficacy and minimize side effect equipping these nanocarriers with the
capability of controlling drug release in response to an appropriate stimulus is essentially required Acidic pH
as an internal stimulus is particular appealing because of the mildly acid pH encountered in tumor tissues and
the intracellular compartments such as endosomes and lysosomes Therefore the pH-responsive drug carriers
have been extensively developed for improving intracellular drug delivery To realize the pH-responsive drug
release we adopted a simple approach to design the lipidPEG-containing complex vesicles with pH-triggered
transmembrane channels as a chemotherapy drug doxorubicin (DOX) delivery carrier In this study the
complex vesicles were attained by spontaneous co-assembly of poly(acrylic acid)-g-poly(monomethoxy
ethylene glycol) (PAAc-g-mPEG) with a cationic lipid didodecyldimethylammonium bromide (DDAB) in
aqueous phase of pH 89 via electrostatic interactions Through the formation of unionized AAc-rich
transmembrance channels of complex vesicles in weak acidic environments the acid-triggered rapid drug
release can be achieved
On the other hand for simultaneously monitoring disease progression and biological response after
treatments we developed a novel tumor-targeting polymersome system capable of delivering magnetic
resonance imaging (MRI) and chemotherapy The DOX-loaded magnetic polymersomes were first attained by
the self-assembly of lipid-containing copolymer poly(AAc-co-distearin acrylate) in aqueous solution
containing citric acid-coated superparamagnetic iron oxide nanoparticles (SPIONs) and followed by DOX
loading via electrostatic attraction To further functionalize these vesicles with superior in vivo colloidal
stability pH-tunable drug release and active tumor-targeting chitosan and poly( -glutamic
acid-co- -glutamyl oxysuccinimide)-g-PEG-folate (FA) were deposited in sequence onto the assembly outer
surfaces The interfacial nanogel layers via electrostatic interactions and in-situ covalent cross-linking were
thus produced Triggerable release of the encapsulated DOX was governed by dual external stimuli pH and
temperature When these theranostic NCPs were effectively internalized by HeLa cells via FA
receptor-mediated endocytosis and then exposed to high frequency magnetic fields (HFMF) the combined
effects of both pH and magnetic hyperthermia-triggered drug release and thermo-therapy resulted in greater
cytotoxicity than the treatment by DOX alone By virtue of the SPION clustering effect in the assembly inner
aqueous compartments the SPIONDOX-loaded NCPs displayed an r2 relaxivity value higher than Resovist
a commercial SPION-based T2 contrast agent The high magnetic relaxivity of the tumor-targeting NCPs
coupled with their enhanced cellular uptake considerably promoted the MRI contrast of targeted cancer cells
These results demonstrate the great potential of the FA-decorated SPIONDOX-loaded NCPs as an advanced
cancer theranostic nanodevice
21
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-1 Prof Hao-Li Liu Professor and Director
Department of Electrical Engineering
Chang Gung University
Phone +886-3-2118800 ext 5677
Fax +886-3-2118026
E-mail haoliliumailcguedutw
Education 2003 PhD National Taiwan University Taipei TAIWAN 1998 M S National Taiwan University Taipei TAIWAN 1996 B S National Taipei University of Technology TAIWAN
Professional Experience 2012-present Director Dept of Electrical Engineering Chang Gung Univ Taiwan 2011-present Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2008 Associate Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2005 ndash2008 Assistant Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2004 ndash2005 Research Fellow Department of Radiology Brigham amp Womenrsquos Hospital Harvard Medical School MA USA
Honor and awards (2009~) 2013 Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) 2013 The 2013 Frederick Lizzi Award International Society of Therapeutic Ultrasound 2011 Distinguished Tech-Coop Award (長庚大學優良教師技合獎) Chang-Gung University 2011 Wu Ta-You Memorial Award (吳大猷先生紀念獎) National Science Council Taiwan 2011 2010 Distinguished Research Award (長庚大學優良教師研究獎) Chang-Gung University
Selected Publication (2010~) HW Yang MY Hua TL Hwang KJ Lin CY Huang RY Tsai CCM Ma PH Hsu SP Wey PW Hsu PY Chen YC Huang YJ Lu TC Yen LY Feng CW Lin HL Liu KC Wei Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide Advanced Materials Vol 25 No 26 pp3605-3611 2013 HL Liu CH Fan CY Ting and CK Yeh Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors Theranostics Vol 4 No 4 pp432-444 2014 KC Wei PC Chu HYJ Wang CY Huang PY Chen HC Tsai YJ Lu IC Tseng PY Lee TC Yen and HL Liu Focused Ultrasound-induced BloodndashBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment A Preclinical Study PLoS ONE Vol 8 No 3 pp e58995 2013 P-H Hsu K-C Wei C-Y Huang C-J Wen T-C Yen C-L Liu Y-T Lin J-C Chen C-R Shen and H-L Liu Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound PLoS ONE Vol 8 No 2 pp e57682 2013 H-L Liu M-Y Hua H-W Yang C-Y Huang P-C Chu J-S Wua I-C Tseng J-J Wang T-C Yen P-Y Chen and K-C Wei ldquoMagnetic resonance monitoring of focused ultrasoundmagnetic nanoparticle targeting delivery of therapeutic agents to the brainrdquo Proceedings of National Academy of Science USA Vol 107 No 34 pp15205-15210 2010 H-L Liu M-Y Hua P-Y Chen P-C Chu C-H Pan H-W Yang C-Y Huang J-J Wang T-C Yen and K-C Wei ldquoBloodndashBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatmentrdquo Radiology Vol 255 No 2 pp 415-425 2010 H-L Liu Y-Y Wai P-H Hsu L-A Lyu J-S Wu C-R Shen J-C Chen T-C Yen and J-J Wang ldquoIn Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Bloodndashbrain Barrier with Focused Ultrasound A Magnetic Resonance Imaging Studyrdquo Journal of Cerebral Blood Flow amp Metabolism Vol 30 pp 168-177 2010
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
1
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Contents
Contents 1
Preface 2
Information 3
Committee 4
List of Session Chairperson 5
List of Invited Speaker 6
Organizer 7
Co-Organizer 7
Map 8
Program 9
Invited Speaker 11
Poster Paper 45
Ministry of Science and Technology (MOST) paper 48
2
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Preface
The aim of Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering
and Environmental Sciences (PT-BMES) is to create starting points of collaborations between
Taiwanese and Japanese researchers on various fields of science and engineering for biomedical and
environmental technologies Through this symposium it is hoped that researchers from both sides
can co-develop new technologies to solve biomedical and environmental problems which have
definitely become the most important issues in both Taiwan and Japan societies Despite the
importance the development of the science and technologies contains a difficulty due to the needs of
interdisciplinary collaboration among multiple academic fields such as nanotechnology
biotechnology chemical engineering medical science pharmaceutical science etc Furthermore the
establishment of future collaborative works in advanced biomedical and environmental technologies
will be keystones for the scientific development of the entire Asia The symposia between them must
be fruitful for the development of the academic field in both Taiwan and Japan which contribute
greatly to the Asian societies This symposium co-organized by the Department of Biomedical
Engineering and Environmental Sciences National Tsing Hua University and the Department of
Materials Science and Technology Tokyo University of Science will be held on September 12
(Friday) to 15 (Monday) 2014 on the campus of the National Tsing Hua University at Hsinchu and
National Center of Traditional Art at I-Lan Taiwan
The objective of this symposium is the promotion of interdisciplinary research for biomedical
and environmental science and technologies both in Taiwan and Japan along with the
intercommunication among the graduate students of both countries to build a foundation stone for the
future collaboration among the scientists in Japan and Taiwan and all Asian countries in future
Representing the organizing committee members we thank to the keynote and invited speakers
and welcome all of the participants to join these symposia to promote fruitful tie-up of Asian
countries
PT-BMES 2014 Organizing Chairs
Prof Chi-Shiun Chiang Prof Kohei Soga
3
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Information
Date September 12-15 2014
Venue Department of Biomedical Engineering and Environmental Sciences National Tsing
Hua University No 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
Website httppt-bmeswebnodetw
Notice for Presenting Authors The full poster abstract download will be available on Sept
12th 2014 on symposium website The attendee are recommended to download the PDF file to
your computer or your pad device
ABSTRACT SUBMISSION
Poster sessions
bull Session A Biomaterials
bull Session B Biomedical Imaging
bull Session C Science and Technology for Environment amp Energy
4
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Committee
Organizing Chair Prof Chi-Shiun Chiang Chairman BMES NTHU Taiwan
Organizing Co-Chair Prof Kohei SOGA PTRC TUS Japan
Symposium Secretariat Prof Shang-Hsiu Hu BMES NTHU Taiwan
Local Organizing Committee Prof Ruey-An Doong NTHU Taiwan
Prof Hsin-Cheng Chiu NTHU Taiwan
Prof Chih-Kuang Yeh NTHU Taiwan
Prof Yu-Fen Huang NTHU Taiwan
Dr Wen-Hsuan Chiang NTHU Taiwan
Prof Tzu-Wei Wang NTHU Taiwan
Prof Chien-Wen Chang NTHU Taiwan
Prof Yuh-Chang Sun NTHU Taiwan
Prof Fu-Nien Wang NTHU Taiwan
Prof Hsu-Hsia Peng NTHU Taiwan
Contact Prof Shang-Hsiu Hu NTHU Taiwan
Email address shhumxnthuedutw
5
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
List of Session Chairperson
Session A Biomaterials Prof Ryo Ishihara (石原量 ) (Professor Dept of Materials Science and Technology Tokyo
University of Science Japan)
Prof Hsin-Cheng Chiu (邱信程) (Professor Dept of Biomedical Engineering and Environmental
Sciences National Tsing Hua University)
Session B Biomedical Imaging Prof Chih-Kuang Yeh (葉秩光) (Professor Dept of Biomedical Engineering and Environmental
Sciences National Tsing Hua University)
Prof Kohei Soga (曽我公平) (Professor Dept of Materials Science and Technology Tokyo
University of Science Japan)
Session C Science and Technology for Environment amp Energy Prof Yu-Fen Huang (黃郁棻) (Professor Dept of Biomedical Engineering and Environmental
Sciences National Tsing Hua University)
Prof Keishi Nishio ( 西 尾 圭 史 ) (Professor Dept of Materials Science and Technology
University of Tsukuba)
6
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
List of Invited Speaker
Session A Biomaterials Prof Yung Chang (張雍) (Professor Dept of Chemical Engineering Chung Yuan University)
Prof Yutaka Ikeda (池田豊) (Professor Dept of Mater Sci University of Tsukuba Japan)
Prof Tzu-Wei Wang (王子威) (Professor Dept of Materials Science and Engineering National
Tsing Hua University)
Prof Ryo Ishihara (石原量) (Assistant Professor Dept of Materials Science and Technology
University of Tsukuba Japan)
Dr Wen-Hsuan Chiang (姜文軒) (Assistant Researcher Dept of Biomedical Engineering and
Environmental Sciences National Tsing Hua University)
Session B Biomedical Imaging Prof Hao-Li Liu (劉浩澧) (Dept of Electrical Engineering Chang Gung University Taiwan)
Dr Ichio Aoki (青木伊知男) (Molecular Imagining Center National Institute of Radiological
Sciences Japan)
Prof Meng-Lin Li (李夢麟) (Associate Professor Dept of Electrical Engineering National Tsing
Hua University)
Prof Tomoko Masaike (政池知子) (Associate Professor Tokyo University of Science Japan)
Prof Chih-Chung Huang(黃執中 ) (Assistant Professor Dept of Biomedical Engineering
National Cheng Kung University)
Prof Masao Kamimura ( 上村真生 ) (Assistant Professor Dept of Materials Science and
Technology University of Tsukuba Japan)
Session C Science and Technology for Environment amp Energy Prof Keishi Nishio (西尾圭史 ) (Professor Dept of Materials Science and Technology
University of Tsukuba)
Prof Hsing-Cheng Hsi (席行正) (Associate Professor Graduate Institute of Environmental
Engineering National Taiwan University)
Prof Kenjiro Fujimoto(藤本憲次郎 )(Department of Pure and Applied Chemistry Tokyo
University of Science)
Prof Fu-Hsiang Ko (柯富祥) (Professor Institute of Nanotechnology National Chiao Tung
University)
Prof Naoto Kitamura (北村尚斗 ) (Associate Professor Department of Pure and Applied
Chemistry Tokyo University of Science)
Prof Zong-Hong Lin (林宗宏 ) (Assistant Professor Institute of Biomedical Engineering
National Tsing Hua University)
7
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Organizer
Department of Biomedical Engineering and Environmental Sciences (BMES)
National Tsing HuaUniversity (NTHU) Taiwan
清華大學 生醫工程與環境科學系
Department of Materials Science and Technologies
Tokyo University of Science (TUS) Japan
東京理科大學 材料科學與技術系
Co-Organizer
Engineering and Technology Promotion Center
National Science Council (NSC) Taiwan
國家科學委員會 工程科技推展中心
College of Nuclear Science
National Tsing Hua Univeristy (NTHU) Taiwan
清華大學 原子科學院
8
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Map
9
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Program
September 12 (Fri) 2014
Time Agenda Speaker
1900~2100 Welcome and Opening Ceremony (Hall of Fame)
September 13 (Sat) 2014 Place NTHU BMES
Time Agenda Speaker
0830~0900 Registration (Entrance Hall NTHU BMES)
0900~0915 Opening Remarks Symposium Chairs
Session A Biomaterials Moderator Hsin-Cheng Chiu (NTHU) Ryo Ishihara (TUS)
0915~0945 Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes (Keynote)
Prof Yung Chang張
雍
0945~1015 Chemical Modifications for the Developments of Next Generation
Drugs (Keynote)
Prof Yutaka Ikeda
池田豊
1015~1045 Electrospun Composite Nanofibers with Staged Release of Multiple
Angiogenic Growth Factors for Chronic Wound Healing (Keynote)
Prof Tzu-Wei Wang
王子威
1045~1110 Break
1110~1140 Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip
toward Point-of-Care Diagnosis (invited)
Prof Ryo Ishihara石
原量
1140~1210 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and
Imaging Applications (Invited)
Dr Wen-Hsuan
Chiang姜文軒
1200~1330 Lunch
Session B Biomedical Imaging Moderator Chih-Kuang Yeh (NTHU) Kohei Soga (TUS)
1320~1400 Focused-Ultrasound Brain-Drug Delivery Approach and
Application (Keynote)
Prof Hao-Li Liu劉
浩澧
1400~1440 Responsive and Theranostic Nano-Contrast Agents for Preclinical
MR Imaging (Keynote)
Dr Ichio Aoki青木
伊知男
1440~1510 Observation of Single-Molecule Enzymes through Probes under the
Optical Microscope (Keynote)
Prof Tomoko
Masaike政池知子
1510~1630 Break
1630~1710 Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing
SPIO Nanoparticles Ultrasonically (Invited)
Prof Meng-Lin Li
李夢麟
1710~1740 High resolution ultrasound elastography for medical applications
(Invited)
Prof Chih-Chung
Huang黃執中
1740~1810 Biofunctional Polymers for Application of Ceramic Nanoparticles
for Fluorescence Bioimaging (Invited)
Prof Masao
Kamimura上村真生
1900~ Banquet (合口味)
10
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
September 14 (Sun) 2014 Place NTHU BMES
Time Agenda Speaker
0845~0900 Registration
Session C Science and Technology for Environment amp Energy
Moderator Yu-Fen Huang (NTHU) Keishi Nishio (TUS)
0900~0930 Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed
Tungsten Oxide Thin Films for Hydrogen Gas Sensor (Keynote)
Prof Keishi Nishio
西尾圭史
0930~1000 Control of low-concentration gaseous mercury from stationary
sources via adsorption and oxidation (Keynote)
Prof Hsing-Cheng
His席行正
1000~1030 High-Throughput Functional Materials Exploration by
Combinatorial WetDry Process (Keynote)
Prof Kenjiro
Fujimoto藤本憲次
郎
1030~1050 Break
1050~1120 Facile Manufacturing on Energy-efficient Devices with Flexibility
and Antireflection (Invited)
Prof Fu-Hsiang Ko
柯富祥
1120~1150 Proton Distribution and Dynamics in BaZrO3-Based Proton
Conductor for Solid Oxide Fuel Cell (Invited)
Prof Naoto
Kitamura北村尚斗
1150~1220 Harvesting Water Energy by a Sequential Contact-Electrification and
Electrostatic-Induction Process (Invited)
Prof Zong-Hong
Lin林宗宏
1210~1330 Lunch
Poster Session
1330~1530 Poster Session
1600~1800 Move to I-Lan
1800~2000 Luodong Night Market
2000 National Center for Traditional Art I-Lan (宜蘭傳藝)
September 15 (Mon) 2014 Place I-Lan
Time Agenda Speaker
0700~0800 Breakfast
0845~0910 Closing Remarks
(National Center for Traditional Art I-Lan)
0910~1500 Visit National Center for Traditional Art
1150~1330 Lunch
1530 Move to Taipei Railway Station or Hsinchu
11
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker
Invited Speaker A-1 Prof Yung Chang
Distinguished Professor
Department of Chemical Engineering
Deputy Director RampD Center for Membrane Technology
Chung Yuan Christian University
Address Jhong-Li Taoyuan 320 Taiwan
TEL (886) 265-4122
FAX (886) 265-4190
Education 2004 PhD Chemical Engineering National Taiwan University Taiwan 2000 MS Chemical Engineering National Taiwan University Taiwan 1998 BS Chemical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013-present Deputy Director RampD Center for Membrane Technology Chung Yuan Christian
University 2013-present Distinguished Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2013-present Professor Department of Chemical Engineering Chung Yuan Christian University
Taiwan 2009-2013 Associate Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2006-2009 Assistant Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2005-2006 Postdoctoral Fellow Chemical Engineering University of Washington USA 2004-2005 Postdoctoral Fellow Chemical Engineering National Taiwan University Taiwan
Honor and awards (2010~) 2010 Yung Investigator Award of Chemical Engineering (Taiwan Institute of Chemical Engineers) 2010 Yung Investigator Award of Materials on Regenerative Medicine (National Health Research
Institutes Taiwan) 2011 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan) 2011 Outstanding Research Award of Chemical Engineering (LCY Chemical Corp) 2012 NSC Wu Da-Yu Award (National science council Taiwan) 2012 NSC Outstanding AcademicIndustrial Cooperation Award (National science council) 2013 Yung Investigator Award of Polymer Science (Taiwan Institute of Polymer Science) 2013 JCS The Distinguished Lectureship Award Biomaterial Research (Japan Chemical Society) 2013 Ukraine International Invention Exhibition Gold Medal (Ukraine Invention Society) 2014 Pittsburgh International Invention Exhibition Gold Medal (USA Invention Society) 2014 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan)
12
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-1 Sep 13 2014 (Sat) 0915-0945 at NTHU BMES R120
Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes
Chung Yuan
RampD Center for Membrane Technology and Department of Chemical Engineering Christian
University Chung-Li Taoyuan 320 Taiwan
Zwitterionic polymeric interface resisting the adsorption of plasma proteins is important in the
development of blood-contacting biomaterials in such applications as blood collection devices
antithrombogenic implants hemodialysis membranes drug-delivery carriers and diagnostic
biosensors Previous studies showed that the control of surface charge neutrality is important for a
zwitterionic surface with effective protein-resistant properties Importantly it was further reported
that the mixed-charge formulation in self-assembled monolayers copolymer hydrogels and
polymeric brushes provide a new avenue to achieve nonfouling surfaces with the prevention of
nonspecific protein adsorption if the charge balance can be well controlled This talk will cover three
major studies
Bio-inert nature of biomimetic zwitterionicpseudozwitterionic structures
Blood-Inert
Surfaces via ion-pair anchoring of zwitterionic copolymer brushes in human whole blood Surface
zwitterionization of membrenaes in novel biomedical applications
[1] Chang Y Liao SC Higuchi A Ruaan RC Chu CW Chen WY A highly stable nonbiofouling surface with
well-packed grafted zwitterionic polysulfobetaine for plasma protein repulsion Langmuir 2008245453-58
[2] Chiag YC Chang Y Higuchi A Chen WY Ruaan RC Sulfobetaine-grafted poly(vinylidene fluroride) ultrafiltration
membranes exhibit excellent antifouling property Journal of Membrane Science 2009339151-9
[3] Chang Y Yandi W Chen WY Shih YJ Yang CC Chang Y Ling QD Higuchi A Tunable bioadhesive copolymer
hydrogels of thermoresponsive poly(N-isopropyl acrylamide) containing zwitterionic polysulfobetaine
Biomacromolecules 2010111101-10
[4] Chang Y Chang WJ Shih YJ Wei TC Hsiue GH Zwitterionic sulfobetaine-grafted poly(vinylidene fluoride)
membrane with improved blood compatibility via atmospheric plasma-induced surface copolymerization ACS Appl
Mater Interfaces 201131228-37
[5] Shih YJ Chang Y Deratani A Damien Q Schizophrenic hemocompatible copolymers via switchable
thermoresponsive transition of nonioniczwitterionic block self-assembly in human blood Biomacromolecules
2012132849minus58
[6] Chang Y Shih YJ Lai CJ Kung HH Jiang S Ion-pair anchoring of self-assembled zwitterionic copolymer surfaces
with highly controlled blood compatibility Advanced Functional Materials 2013231100-10
13
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-2 Dr Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences
University of Tsukuba
Address Tennoudai 1-1-1 Tsukuba Ibaraki 305-8573 Japan
E-mailikedaimstsukubaacjp
Education March 1999 B S in Faculty of Engineering Kyoto University March 2001 MS in Graduate School of Engineering Department of Synthetic Chemistry and
Biological Chemistry Kyoto University March 2004 PhD in School of Engineering The University of Tokyo
Professional Experience 2004~2006 Advanced industrial science and technology (AIST) 2006~2008 Cytopathfinder Inc 2008~to date University of Tsukuba
Selected Publication (2010~) Y Ikeda J Katamachi H Kawasaki Y Nagasaki Novel protein PEGylation chemistry via glutalaldehydefunctionalized PEG Bioconjugate Chemistry 24 1824-1827 (2013) Y Ikeda D Kubota Y Nagasaki Design of sugar-oligonucleotide conjugates installed gold nanoparticle for effective delivery to hepatic parenchymal cells Colloid and Polymer Science 291 2959-2964 Y Ikeda H Kawasaki S Ichinohe Y Nagasaki Facile solid-phase synthesis of a highly stable poly(ethylene glycol)-oligonucleotide conjugate Journal of Materials Chemistry B 1 529-535(2013) Y Ikeda T Jomura U Horiuchi J Saeki K Yoshimoto T Ikeya Y Nagasaki Long-term survival and functional maintenance of hepatocytes by using a microfabricated cell array Colloid and Surface B Biointerface 97 97-100 2012 Y Ikeda Y Nagasaki PEGylation Technology in Nanomedicine Advances in Polymer Science 247 115-140 2012 Y Ikeda R Suzuki T Yoshitomi Y Nagasaki Novel oligonucleotide carrier possessing reactive oxygen species scavenging ability Macromolecular Bioscience 2011 11 344-351 Y Ikeda D Kubota Y Nagasaki Simple solid-phase synthesis and biological properties of carbohydrate-oligonucleotide conjugates modified at the 3rsquo terminus Bioconjugate Chem 2010 21 1685-1690
14
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-2 Sep 13 2014 (Sat) 0945-1015 at NTHU BMES R120
Chemical Modifications for the Developments of Next Generation Drugs
Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences University of
Tsukuba
Controlling of biodistribution and PKPD is a key issue for the development of drugsVariety of
technologies have been reported to improve those properties Those technologies include
nanoparticle formulation and PEGylation technology In my presentation I will show recent
chemical modification technologies which we developed to improve PKPD and distribution of
drugs
A novel chemistry for the PEGylated protein with a high activity
Several PEGylated proteins have been approved as therapeutic drugs In many cases PEGylated
protein has been synthesized by the conjugation reaction between PEG possessing activated ester and
amine(s) in the protein This reaction however often causes inactivation of PEGylated proteins In
this report we present a novel chemistry which enables the PEGylation of proteins under the mild
reaction condition PEGylated lysozyme prepared by the method developed increased the biological
activity of the PEGylated lysozyme more than 20 times compared with the PEGylated lysozyme
prepared by the conventional method
Design and development of novel hypoxically activated prodrugs
Tumor hypoxia is well known to promote mutagenesis invasiveness and to be associated with a
worse prognosis Although the treatment of the tumor hypoxia has been highly demanded resistance
to radiotherapy and anticancer chemotherapy have been serious problems The object of this study
was the development of hypoxically activated prodrugs which accumulate and act on cells at hypoxic
region of tumor Several conventional anti-cancer drugs including doxorubicin gemcitabine and 5FU
have been modified with 2-nitro imidazole derivative This modification enabled inactivation of drug
to reduce adverse effects under the normoxia condition and selective activation of prodrug under the
hypoxic condition
15
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-3 Prof Tzu-Wei Wang
Associate Professor
Department of Materials Science and Engineering and Institute of Biomedical
Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013
Office Delta Teaching Building R434
TEL +886-3-5715131 ext 33856
Email twwangmxnthuedutw Education 2006 PhD Institute of Biomedical Engineering National Taiwan University Taiwan
Professional Experience 2013 ndashpresent Associate Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2009 -2013 Assistant Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2007-2009 Postdoctoral Research Fellow Tissue Engineering Laboratories of Brigham and Womenrsquos
Hospital Harvard Medical School USA
Honor and awards (2009~) Young Plenary Award 2013 TERMIS-AP Symposium Shanghai China (2013) The 9th National Innovation Award Academic Research Category by Institute for Biotechnology and Medicine Industry Taiwan (2012) Young Investigator Award International Symposium of Materials on Regenerative Medicine Taiwan (2012 ISOMRM) Young Investigator Award 5th World Congress on Bioengineering the World Association for Chinese Biomedical Engineers Taiwan (WACBE 2011)
Selected Publication (2012~) Yang CS Wu HC Sun JS Hsiao HM Wang TW Thermo-induced shape memory PEG-PCL copolymer as dual drug-eluting biodegradable stent ACS Appl Mater Interfaces 2013 5 (21) 10985ndash10994 Yeh PH Sun JS Wu HC Hwang LH Wang TW Stimuli-responsive HA-PEI nanoparticles encapsulating endostatin plasmid for stem cell gene therapy RSC Advances 2013 3 (31) 12922 - 12932 Chen YY Wu HC Sun JS Dong GC Wang TW Injectable and thermoresponsive self-assembled nanocomposite hydrogel for long-term anticancer drug delivery Langmuir 201329(11)3721-3729 Cheng TY Wu HC Chang WH Huang MY Lee CH Wang TW Self-assembling functionalized nanopeptides for immediate hemostasis and accelerative liver tissue regeneration Nanoscale 2013 5 (7) 2734 - 2744 Chang YJ Tsai CJ Tseng FG Chen TJ Wang TW Micropatterned Stretching System for the Investigation of Mechanical Tension on Neural Stem Cells Behavior Nanomedicine Nanotechnology Biology and Medicine 20139345-355 Cheng TY Chen MH Chang WH Huang MY Wang TW Neural stem cells encapsulated in a functionalized self-assembling peptide hydrogel for brain tissue engineering Biomaterials 2013 34(8)2005-2016 Goh JH Wu HC Chen MH Chen MY Chang SC Wang TW Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages Acta Biomaterialia 20139(2)5170-5180 Huang YJ Wu HC Tai NH Wang TW Carbon Nanotube Rope with Electrical Stimulation Promotes the Differentiation and Maturity of Neural Stem Cells Small 20128(18) 2869ndash2877
16
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-3 Sep 13 2014 (Sat) 1015-1045 at NTHU BMES R120
Electrospun Composite Nanofibers with Staged Release of Multiple Angiogenic Growth Factors for Chronic Wound Healing
Tzu-Wei Wang
Department of Materials Science and Engineering and Institute of Biomedical Engineering National
Tsing Hua University
The objective of this research study is to develop collagen (Col) and hyaluronic acid (HA)
inter-stacking nanofibrous skin equivalent substitute with programmable release of multiple
angiogenic growth factors (VEGF PDGF bFGF and EGF) either directly embedded in the
nanofibers or encapsulated in the gelatin nanoparticles (GN) by electrospinning technology The
delivery of EGF and bFGF in early stage is expected to accelerate epithelialization and vasculature
sprouting while release of PDGF and VEGF in late stage is aimed for the induction of blood vessels
maturation The physiochemical characterizations report that the Col-HA-GN nanofibrous membrane
possesses mechanical property similar to human native skin The design of particle-in-fiber structure
allows growth factors for slow controlled release up to one month Cultured on biodegradable
Col-HA membrane with four kinds of growth factors (Col-HA w4GF) endothelial cells not only
increase in growth rate but also form better network of thread-like tubular structure Therapeutic
effect of Col-HA w4GF membrane on STZ-induced diabetic rats reveal accelerated wound closure
rate elevated collagen deposition and enhanced mature vessels by Massonrsquos trichrome stain and
immunohistochemical analysis respectively From the above the electrospun Col-HA-GN composite
nanofibrous skin substitute with stage-wise release pattern of multiple angiogenic factors could be a
promising bioengineered construct for the chronic wound healing in skin tissue regeneration
17
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-4 Assistant Prof Ryo Ishihara
Assistant Professor
Department of Materials Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
Tokyo University of Science Research Building 9th floor
TEL +81-3-5876-1415
FAX +81-3-5876-1415
Education 2012 PhD Department of Applied Chemistry and Biotechnology Chiba University Japan 2008 MS Department of Materials Technology Chiba University Japan 2006 BS Department of Materials Technology Chiba University Japan
Professional Experience 2014 ndashpresent Assistant Professor Department of Materials Science and Technology Tokyo
University of Science 2012 ndash2014 Postdoctral Researcher Bioengineering Laboratory RIKEN
Honor and awards Department chairmanlsquos award from Chiba University (2012)
Selected Publication (2010~) Simple Method for High-Density Impregnation of Aliquat 336 onto Porous Sheet and Binding Performance of Resulting Sheet for Palladium Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota Sep Sci Technol 49154-159 (2014) Effect of Dose on Mole Percentage of Polymer Brush and Root Grafted onto Porous Polyethylene Sheet by Radiation-Induced Graft Polymerization R Ishihara S Uchiyama H Ikezawa S Yamada H Hirota D Umeno K Saito Ind Eng Chem Res 5212582-12586 (2013) Determination of Mole Percentages of Brush and Root of Polymer Chain Grafted onto Porous Sheet S Uchiyama R Ishihara D Umeno K Saito S Yamada H Hirota S Asai J Chem Eng Japan 46414-419 (2013) Crosslinked-chelating Porous Sheet with High Dynamic Binding Capacity of Metal Ions G Wada R Ishihara K Miyoshi D Umeno K Saito S Yamada H Hirota Solv Extr Ion Exch 31210-220 (2013) Dependence of Lanthanide-Ion Binding Performance on HDEHP Concentration in HDEHP Impregnation to Porous Sheet R Ishihara S Asai S Otosaka S Yamada H Hirota K Miyoshi D Umeno K Saito Solv Extr Ion Exch 30171-180 (2012) Impregnation of TOPO onto Hydrophobic-Ligand-Containing Porous Sheet and Its Adsorptionelution Performance of Bismuth Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota React Funct Polym 70986-990 (2010)
18
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-4 Sep 13 2014 (Sat) 1110-1140 at NTHU BMES R120
Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip toward Point-of-Care Diagnosis
Ryo Ishihara Kazuo Hosokawa Mizuo Maeda
Bioengineering Laboratory RIKEN
MicroRNAs (miRNAs) are short and non-protein-coding single-stranded RNAs and have shown great promise for
cancer diagnosis Some miRNAs circulate in human body fluid with extremely low concentrations and its expression
profiling can detect and classify cancers in the human body [1] Point-of-care (POC) diagnosis requires short detection
time small required sample volume and portability of the device In various miRNA detection methods microfluidic
chip meets the requirements except the portability Hence we used our power-free pump-free microfluidic chip driven
by energy that is stored in degased PDMS to overcome those drawbacks which eliminates the need for external power
sources for fluid pumping [2] The pump-free pumping method is essential for microfluidic chip-based POC diagnosis In
our laboratory rapid and sensitive singleplex miRNA detection with laminar flow-assisted dendritic amplification (LFDA)
[3] on the pump-free microfluidic chip has been developed [4] In this study rapid and sensitive multiplex miRNA
detection on the pump-free microfluidic chip was demonstrated
Pump-free microchip for multiplex miRNA detection was prepared as follows First the PDMS part with a pair of
Y-shaped microchannels with 100 μm in width and 25 μm in height was fabricated Second three parallel-line-shaped
probe DNAs were patterned onto a glass surface Third the PDMS channels were attached onto the glass plate Finally
the chip was degassed in a vacuum chamber After the chip preparation target miRNAs were detected following three
steps (1) blocking (2) sandwich hybridization of the target miRNAs and biotinylated probe DNAs and (3) signal
amplification by LFDA MiR-16 miR-21-5p and miR-500a-3p were used as target miRNAs since they are known as
cancer biomarkers [5-7] Fluorescence signals were captured by CCD camera and analyzed by the software (ImageJ)
Bright lines appeared at the expected positions they appeared only on the areas with the respective probe DNA in which
the target miRNAs had been supplied These data prove that the LFDA successfully took place in a target
sequence-dependent manner Calibration curves were plotted from the fluorescence signals The data points of the
calibration curve were fitted with the four-parameter logistic function and limit-of-detections (LODs) were evaluated by
the 3σ criterion LODs of the miR-16 miR-21-5p and miR-500a-3p were 68 fM 15 pM and 150 fM respectively The
LODs are on the same order of magnitude as concentrations of miRNA in blood Multiplex detection was verified from
correspondence between the calibration curves of single and multiplex The required sample volume was 05 microL and
assay time was 20 min Because most of the existing methods take more than a few hours the rapidness small required
sample volume and portability of the device are ideal advantages for POC diagnosis
References
[1] PS Mitchell et al PNAS 105 (2008) 10513 [2] K Hosokawa et al Lab Chip 4 (2004) 181 [3] K Hosokawa et al Anal
Chem 79 (2007) 6000 [4] H Arata et al PLoS ONE 7 (2012) e48329 [5] MJ Lodes et al PLoS ONE 4 (2009) e6229
[6] Y Toiyama et al J Natl Cancer Inst 105 (2013) 849 [7] Y Yamamoto et al Biomarkers 14 (2009) 529
19
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-5 Dr Wen-Hsuan Chiang
Assistant Researcher
Department of Biomedical Engineering and Environmental Sciences
National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
TEL (886) 3-571-5131 ext 35576
Education 2009 PhD Department of Chemical Engineering National Chung Hsing University Taiwan Thesis Supervisor Professor Hsin-Cheng Chiu 2002 BS Department of Chemical Engineering Tatung University Taiwan Professional Experience 2013 ndashpresent Assistant Researcher Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University 2010 ndash2012 Postdoctoral Fellow Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
Areas of Research Expertise Biomaterials Smart Amphiphilic Copolymers Multifunctional Nanocarriers for Cancer Therapy and Imaging Nano Science and Interfacial Engineering
Selected Publication (2010~) Wen-Hsuan Chiang Wen-Chia Huang Ming-Yin Shen Che-Hsu Wang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Dual-Layered Nanogel-Coated Hollow LipidPolypeptide Conjugate Assemblies for Potential pH-Triggered Intracellular Drug Release PLOS ONE 2014 9 1-11 Wen-Hsuan Chiang Wen-Chia Huang Chien-Wen Chang Ming-Yin Shen Zong-Fu Shih Yi-Fong Huang Sung-Chyr Lin Hsin-Cheng Chiu Functionalized Polymersomes with Outlayered Polyelectrolyte Gels for Potential Tumor-Targeted Delivery of Multimodal Therapies and MR Imaging Journal of Controlled Release 2013 168 280-288 Wen-Hsuan Chiang Viet Thang Ho Hsin-Hung Chen Wen-Chia Huang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Superparamagnetic Hollow Hybrid Nanogels as a Potential Guidable Vehicle System of Stimuli-Mediated MR Imaging and Multiple Cancer Therapeutics Langmuir 2013 29 6434-6443 Wen-Hsuan Chiang Viet Thang Ho Wen-Chia Huang Yi-Fong Huang Chorng-Shyan Chern Hsin-Cheng Chiu Dual Stimuli-Responsive Polymeric Hollow Nanogels Designed as Carriers for Intracellular Triggered Drug Release Langmuir 2012 28 15056-15064 Yi-Fong HuangDagger Wen-Hsuan ChiangDagger Pei-Ling Tsai Chorng-Shyan Chern Hsin-Cheng Chiu Novel Hybrid Vesicles Co-Assembled from Cationic Lipid and PAAc-g-mPEG with pH-Triggered Transmembrane Channels for Controlled Drug Release Chemical Communications 2011 47 10978-10980
20
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-5 Sep 13 2014 (Sat) 1140-1210 at NTHU BMES R120 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and Imaging
Applications
Wen-Hsuan Chiang
Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
In order to promote therapeutic efficacy and minimize side effect equipping these nanocarriers with the
capability of controlling drug release in response to an appropriate stimulus is essentially required Acidic pH
as an internal stimulus is particular appealing because of the mildly acid pH encountered in tumor tissues and
the intracellular compartments such as endosomes and lysosomes Therefore the pH-responsive drug carriers
have been extensively developed for improving intracellular drug delivery To realize the pH-responsive drug
release we adopted a simple approach to design the lipidPEG-containing complex vesicles with pH-triggered
transmembrane channels as a chemotherapy drug doxorubicin (DOX) delivery carrier In this study the
complex vesicles were attained by spontaneous co-assembly of poly(acrylic acid)-g-poly(monomethoxy
ethylene glycol) (PAAc-g-mPEG) with a cationic lipid didodecyldimethylammonium bromide (DDAB) in
aqueous phase of pH 89 via electrostatic interactions Through the formation of unionized AAc-rich
transmembrance channels of complex vesicles in weak acidic environments the acid-triggered rapid drug
release can be achieved
On the other hand for simultaneously monitoring disease progression and biological response after
treatments we developed a novel tumor-targeting polymersome system capable of delivering magnetic
resonance imaging (MRI) and chemotherapy The DOX-loaded magnetic polymersomes were first attained by
the self-assembly of lipid-containing copolymer poly(AAc-co-distearin acrylate) in aqueous solution
containing citric acid-coated superparamagnetic iron oxide nanoparticles (SPIONs) and followed by DOX
loading via electrostatic attraction To further functionalize these vesicles with superior in vivo colloidal
stability pH-tunable drug release and active tumor-targeting chitosan and poly( -glutamic
acid-co- -glutamyl oxysuccinimide)-g-PEG-folate (FA) were deposited in sequence onto the assembly outer
surfaces The interfacial nanogel layers via electrostatic interactions and in-situ covalent cross-linking were
thus produced Triggerable release of the encapsulated DOX was governed by dual external stimuli pH and
temperature When these theranostic NCPs were effectively internalized by HeLa cells via FA
receptor-mediated endocytosis and then exposed to high frequency magnetic fields (HFMF) the combined
effects of both pH and magnetic hyperthermia-triggered drug release and thermo-therapy resulted in greater
cytotoxicity than the treatment by DOX alone By virtue of the SPION clustering effect in the assembly inner
aqueous compartments the SPIONDOX-loaded NCPs displayed an r2 relaxivity value higher than Resovist
a commercial SPION-based T2 contrast agent The high magnetic relaxivity of the tumor-targeting NCPs
coupled with their enhanced cellular uptake considerably promoted the MRI contrast of targeted cancer cells
These results demonstrate the great potential of the FA-decorated SPIONDOX-loaded NCPs as an advanced
cancer theranostic nanodevice
21
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-1 Prof Hao-Li Liu Professor and Director
Department of Electrical Engineering
Chang Gung University
Phone +886-3-2118800 ext 5677
Fax +886-3-2118026
E-mail haoliliumailcguedutw
Education 2003 PhD National Taiwan University Taipei TAIWAN 1998 M S National Taiwan University Taipei TAIWAN 1996 B S National Taipei University of Technology TAIWAN
Professional Experience 2012-present Director Dept of Electrical Engineering Chang Gung Univ Taiwan 2011-present Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2008 Associate Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2005 ndash2008 Assistant Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2004 ndash2005 Research Fellow Department of Radiology Brigham amp Womenrsquos Hospital Harvard Medical School MA USA
Honor and awards (2009~) 2013 Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) 2013 The 2013 Frederick Lizzi Award International Society of Therapeutic Ultrasound 2011 Distinguished Tech-Coop Award (長庚大學優良教師技合獎) Chang-Gung University 2011 Wu Ta-You Memorial Award (吳大猷先生紀念獎) National Science Council Taiwan 2011 2010 Distinguished Research Award (長庚大學優良教師研究獎) Chang-Gung University
Selected Publication (2010~) HW Yang MY Hua TL Hwang KJ Lin CY Huang RY Tsai CCM Ma PH Hsu SP Wey PW Hsu PY Chen YC Huang YJ Lu TC Yen LY Feng CW Lin HL Liu KC Wei Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide Advanced Materials Vol 25 No 26 pp3605-3611 2013 HL Liu CH Fan CY Ting and CK Yeh Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors Theranostics Vol 4 No 4 pp432-444 2014 KC Wei PC Chu HYJ Wang CY Huang PY Chen HC Tsai YJ Lu IC Tseng PY Lee TC Yen and HL Liu Focused Ultrasound-induced BloodndashBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment A Preclinical Study PLoS ONE Vol 8 No 3 pp e58995 2013 P-H Hsu K-C Wei C-Y Huang C-J Wen T-C Yen C-L Liu Y-T Lin J-C Chen C-R Shen and H-L Liu Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound PLoS ONE Vol 8 No 2 pp e57682 2013 H-L Liu M-Y Hua H-W Yang C-Y Huang P-C Chu J-S Wua I-C Tseng J-J Wang T-C Yen P-Y Chen and K-C Wei ldquoMagnetic resonance monitoring of focused ultrasoundmagnetic nanoparticle targeting delivery of therapeutic agents to the brainrdquo Proceedings of National Academy of Science USA Vol 107 No 34 pp15205-15210 2010 H-L Liu M-Y Hua P-Y Chen P-C Chu C-H Pan H-W Yang C-Y Huang J-J Wang T-C Yen and K-C Wei ldquoBloodndashBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatmentrdquo Radiology Vol 255 No 2 pp 415-425 2010 H-L Liu Y-Y Wai P-H Hsu L-A Lyu J-S Wu C-R Shen J-C Chen T-C Yen and J-J Wang ldquoIn Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Bloodndashbrain Barrier with Focused Ultrasound A Magnetic Resonance Imaging Studyrdquo Journal of Cerebral Blood Flow amp Metabolism Vol 30 pp 168-177 2010
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
2
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Preface
The aim of Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering
and Environmental Sciences (PT-BMES) is to create starting points of collaborations between
Taiwanese and Japanese researchers on various fields of science and engineering for biomedical and
environmental technologies Through this symposium it is hoped that researchers from both sides
can co-develop new technologies to solve biomedical and environmental problems which have
definitely become the most important issues in both Taiwan and Japan societies Despite the
importance the development of the science and technologies contains a difficulty due to the needs of
interdisciplinary collaboration among multiple academic fields such as nanotechnology
biotechnology chemical engineering medical science pharmaceutical science etc Furthermore the
establishment of future collaborative works in advanced biomedical and environmental technologies
will be keystones for the scientific development of the entire Asia The symposia between them must
be fruitful for the development of the academic field in both Taiwan and Japan which contribute
greatly to the Asian societies This symposium co-organized by the Department of Biomedical
Engineering and Environmental Sciences National Tsing Hua University and the Department of
Materials Science and Technology Tokyo University of Science will be held on September 12
(Friday) to 15 (Monday) 2014 on the campus of the National Tsing Hua University at Hsinchu and
National Center of Traditional Art at I-Lan Taiwan
The objective of this symposium is the promotion of interdisciplinary research for biomedical
and environmental science and technologies both in Taiwan and Japan along with the
intercommunication among the graduate students of both countries to build a foundation stone for the
future collaboration among the scientists in Japan and Taiwan and all Asian countries in future
Representing the organizing committee members we thank to the keynote and invited speakers
and welcome all of the participants to join these symposia to promote fruitful tie-up of Asian
countries
PT-BMES 2014 Organizing Chairs
Prof Chi-Shiun Chiang Prof Kohei Soga
3
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Information
Date September 12-15 2014
Venue Department of Biomedical Engineering and Environmental Sciences National Tsing
Hua University No 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
Website httppt-bmeswebnodetw
Notice for Presenting Authors The full poster abstract download will be available on Sept
12th 2014 on symposium website The attendee are recommended to download the PDF file to
your computer or your pad device
ABSTRACT SUBMISSION
Poster sessions
bull Session A Biomaterials
bull Session B Biomedical Imaging
bull Session C Science and Technology for Environment amp Energy
4
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Committee
Organizing Chair Prof Chi-Shiun Chiang Chairman BMES NTHU Taiwan
Organizing Co-Chair Prof Kohei SOGA PTRC TUS Japan
Symposium Secretariat Prof Shang-Hsiu Hu BMES NTHU Taiwan
Local Organizing Committee Prof Ruey-An Doong NTHU Taiwan
Prof Hsin-Cheng Chiu NTHU Taiwan
Prof Chih-Kuang Yeh NTHU Taiwan
Prof Yu-Fen Huang NTHU Taiwan
Dr Wen-Hsuan Chiang NTHU Taiwan
Prof Tzu-Wei Wang NTHU Taiwan
Prof Chien-Wen Chang NTHU Taiwan
Prof Yuh-Chang Sun NTHU Taiwan
Prof Fu-Nien Wang NTHU Taiwan
Prof Hsu-Hsia Peng NTHU Taiwan
Contact Prof Shang-Hsiu Hu NTHU Taiwan
Email address shhumxnthuedutw
5
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
List of Session Chairperson
Session A Biomaterials Prof Ryo Ishihara (石原量 ) (Professor Dept of Materials Science and Technology Tokyo
University of Science Japan)
Prof Hsin-Cheng Chiu (邱信程) (Professor Dept of Biomedical Engineering and Environmental
Sciences National Tsing Hua University)
Session B Biomedical Imaging Prof Chih-Kuang Yeh (葉秩光) (Professor Dept of Biomedical Engineering and Environmental
Sciences National Tsing Hua University)
Prof Kohei Soga (曽我公平) (Professor Dept of Materials Science and Technology Tokyo
University of Science Japan)
Session C Science and Technology for Environment amp Energy Prof Yu-Fen Huang (黃郁棻) (Professor Dept of Biomedical Engineering and Environmental
Sciences National Tsing Hua University)
Prof Keishi Nishio ( 西 尾 圭 史 ) (Professor Dept of Materials Science and Technology
University of Tsukuba)
6
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
List of Invited Speaker
Session A Biomaterials Prof Yung Chang (張雍) (Professor Dept of Chemical Engineering Chung Yuan University)
Prof Yutaka Ikeda (池田豊) (Professor Dept of Mater Sci University of Tsukuba Japan)
Prof Tzu-Wei Wang (王子威) (Professor Dept of Materials Science and Engineering National
Tsing Hua University)
Prof Ryo Ishihara (石原量) (Assistant Professor Dept of Materials Science and Technology
University of Tsukuba Japan)
Dr Wen-Hsuan Chiang (姜文軒) (Assistant Researcher Dept of Biomedical Engineering and
Environmental Sciences National Tsing Hua University)
Session B Biomedical Imaging Prof Hao-Li Liu (劉浩澧) (Dept of Electrical Engineering Chang Gung University Taiwan)
Dr Ichio Aoki (青木伊知男) (Molecular Imagining Center National Institute of Radiological
Sciences Japan)
Prof Meng-Lin Li (李夢麟) (Associate Professor Dept of Electrical Engineering National Tsing
Hua University)
Prof Tomoko Masaike (政池知子) (Associate Professor Tokyo University of Science Japan)
Prof Chih-Chung Huang(黃執中 ) (Assistant Professor Dept of Biomedical Engineering
National Cheng Kung University)
Prof Masao Kamimura ( 上村真生 ) (Assistant Professor Dept of Materials Science and
Technology University of Tsukuba Japan)
Session C Science and Technology for Environment amp Energy Prof Keishi Nishio (西尾圭史 ) (Professor Dept of Materials Science and Technology
University of Tsukuba)
Prof Hsing-Cheng Hsi (席行正) (Associate Professor Graduate Institute of Environmental
Engineering National Taiwan University)
Prof Kenjiro Fujimoto(藤本憲次郎 )(Department of Pure and Applied Chemistry Tokyo
University of Science)
Prof Fu-Hsiang Ko (柯富祥) (Professor Institute of Nanotechnology National Chiao Tung
University)
Prof Naoto Kitamura (北村尚斗 ) (Associate Professor Department of Pure and Applied
Chemistry Tokyo University of Science)
Prof Zong-Hong Lin (林宗宏 ) (Assistant Professor Institute of Biomedical Engineering
National Tsing Hua University)
7
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Organizer
Department of Biomedical Engineering and Environmental Sciences (BMES)
National Tsing HuaUniversity (NTHU) Taiwan
清華大學 生醫工程與環境科學系
Department of Materials Science and Technologies
Tokyo University of Science (TUS) Japan
東京理科大學 材料科學與技術系
Co-Organizer
Engineering and Technology Promotion Center
National Science Council (NSC) Taiwan
國家科學委員會 工程科技推展中心
College of Nuclear Science
National Tsing Hua Univeristy (NTHU) Taiwan
清華大學 原子科學院
8
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Map
9
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Program
September 12 (Fri) 2014
Time Agenda Speaker
1900~2100 Welcome and Opening Ceremony (Hall of Fame)
September 13 (Sat) 2014 Place NTHU BMES
Time Agenda Speaker
0830~0900 Registration (Entrance Hall NTHU BMES)
0900~0915 Opening Remarks Symposium Chairs
Session A Biomaterials Moderator Hsin-Cheng Chiu (NTHU) Ryo Ishihara (TUS)
0915~0945 Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes (Keynote)
Prof Yung Chang張
雍
0945~1015 Chemical Modifications for the Developments of Next Generation
Drugs (Keynote)
Prof Yutaka Ikeda
池田豊
1015~1045 Electrospun Composite Nanofibers with Staged Release of Multiple
Angiogenic Growth Factors for Chronic Wound Healing (Keynote)
Prof Tzu-Wei Wang
王子威
1045~1110 Break
1110~1140 Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip
toward Point-of-Care Diagnosis (invited)
Prof Ryo Ishihara石
原量
1140~1210 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and
Imaging Applications (Invited)
Dr Wen-Hsuan
Chiang姜文軒
1200~1330 Lunch
Session B Biomedical Imaging Moderator Chih-Kuang Yeh (NTHU) Kohei Soga (TUS)
1320~1400 Focused-Ultrasound Brain-Drug Delivery Approach and
Application (Keynote)
Prof Hao-Li Liu劉
浩澧
1400~1440 Responsive and Theranostic Nano-Contrast Agents for Preclinical
MR Imaging (Keynote)
Dr Ichio Aoki青木
伊知男
1440~1510 Observation of Single-Molecule Enzymes through Probes under the
Optical Microscope (Keynote)
Prof Tomoko
Masaike政池知子
1510~1630 Break
1630~1710 Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing
SPIO Nanoparticles Ultrasonically (Invited)
Prof Meng-Lin Li
李夢麟
1710~1740 High resolution ultrasound elastography for medical applications
(Invited)
Prof Chih-Chung
Huang黃執中
1740~1810 Biofunctional Polymers for Application of Ceramic Nanoparticles
for Fluorescence Bioimaging (Invited)
Prof Masao
Kamimura上村真生
1900~ Banquet (合口味)
10
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
September 14 (Sun) 2014 Place NTHU BMES
Time Agenda Speaker
0845~0900 Registration
Session C Science and Technology for Environment amp Energy
Moderator Yu-Fen Huang (NTHU) Keishi Nishio (TUS)
0900~0930 Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed
Tungsten Oxide Thin Films for Hydrogen Gas Sensor (Keynote)
Prof Keishi Nishio
西尾圭史
0930~1000 Control of low-concentration gaseous mercury from stationary
sources via adsorption and oxidation (Keynote)
Prof Hsing-Cheng
His席行正
1000~1030 High-Throughput Functional Materials Exploration by
Combinatorial WetDry Process (Keynote)
Prof Kenjiro
Fujimoto藤本憲次
郎
1030~1050 Break
1050~1120 Facile Manufacturing on Energy-efficient Devices with Flexibility
and Antireflection (Invited)
Prof Fu-Hsiang Ko
柯富祥
1120~1150 Proton Distribution and Dynamics in BaZrO3-Based Proton
Conductor for Solid Oxide Fuel Cell (Invited)
Prof Naoto
Kitamura北村尚斗
1150~1220 Harvesting Water Energy by a Sequential Contact-Electrification and
Electrostatic-Induction Process (Invited)
Prof Zong-Hong
Lin林宗宏
1210~1330 Lunch
Poster Session
1330~1530 Poster Session
1600~1800 Move to I-Lan
1800~2000 Luodong Night Market
2000 National Center for Traditional Art I-Lan (宜蘭傳藝)
September 15 (Mon) 2014 Place I-Lan
Time Agenda Speaker
0700~0800 Breakfast
0845~0910 Closing Remarks
(National Center for Traditional Art I-Lan)
0910~1500 Visit National Center for Traditional Art
1150~1330 Lunch
1530 Move to Taipei Railway Station or Hsinchu
11
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker
Invited Speaker A-1 Prof Yung Chang
Distinguished Professor
Department of Chemical Engineering
Deputy Director RampD Center for Membrane Technology
Chung Yuan Christian University
Address Jhong-Li Taoyuan 320 Taiwan
TEL (886) 265-4122
FAX (886) 265-4190
Education 2004 PhD Chemical Engineering National Taiwan University Taiwan 2000 MS Chemical Engineering National Taiwan University Taiwan 1998 BS Chemical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013-present Deputy Director RampD Center for Membrane Technology Chung Yuan Christian
University 2013-present Distinguished Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2013-present Professor Department of Chemical Engineering Chung Yuan Christian University
Taiwan 2009-2013 Associate Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2006-2009 Assistant Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2005-2006 Postdoctoral Fellow Chemical Engineering University of Washington USA 2004-2005 Postdoctoral Fellow Chemical Engineering National Taiwan University Taiwan
Honor and awards (2010~) 2010 Yung Investigator Award of Chemical Engineering (Taiwan Institute of Chemical Engineers) 2010 Yung Investigator Award of Materials on Regenerative Medicine (National Health Research
Institutes Taiwan) 2011 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan) 2011 Outstanding Research Award of Chemical Engineering (LCY Chemical Corp) 2012 NSC Wu Da-Yu Award (National science council Taiwan) 2012 NSC Outstanding AcademicIndustrial Cooperation Award (National science council) 2013 Yung Investigator Award of Polymer Science (Taiwan Institute of Polymer Science) 2013 JCS The Distinguished Lectureship Award Biomaterial Research (Japan Chemical Society) 2013 Ukraine International Invention Exhibition Gold Medal (Ukraine Invention Society) 2014 Pittsburgh International Invention Exhibition Gold Medal (USA Invention Society) 2014 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan)
12
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-1 Sep 13 2014 (Sat) 0915-0945 at NTHU BMES R120
Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes
Chung Yuan
RampD Center for Membrane Technology and Department of Chemical Engineering Christian
University Chung-Li Taoyuan 320 Taiwan
Zwitterionic polymeric interface resisting the adsorption of plasma proteins is important in the
development of blood-contacting biomaterials in such applications as blood collection devices
antithrombogenic implants hemodialysis membranes drug-delivery carriers and diagnostic
biosensors Previous studies showed that the control of surface charge neutrality is important for a
zwitterionic surface with effective protein-resistant properties Importantly it was further reported
that the mixed-charge formulation in self-assembled monolayers copolymer hydrogels and
polymeric brushes provide a new avenue to achieve nonfouling surfaces with the prevention of
nonspecific protein adsorption if the charge balance can be well controlled This talk will cover three
major studies
Bio-inert nature of biomimetic zwitterionicpseudozwitterionic structures
Blood-Inert
Surfaces via ion-pair anchoring of zwitterionic copolymer brushes in human whole blood Surface
zwitterionization of membrenaes in novel biomedical applications
[1] Chang Y Liao SC Higuchi A Ruaan RC Chu CW Chen WY A highly stable nonbiofouling surface with
well-packed grafted zwitterionic polysulfobetaine for plasma protein repulsion Langmuir 2008245453-58
[2] Chiag YC Chang Y Higuchi A Chen WY Ruaan RC Sulfobetaine-grafted poly(vinylidene fluroride) ultrafiltration
membranes exhibit excellent antifouling property Journal of Membrane Science 2009339151-9
[3] Chang Y Yandi W Chen WY Shih YJ Yang CC Chang Y Ling QD Higuchi A Tunable bioadhesive copolymer
hydrogels of thermoresponsive poly(N-isopropyl acrylamide) containing zwitterionic polysulfobetaine
Biomacromolecules 2010111101-10
[4] Chang Y Chang WJ Shih YJ Wei TC Hsiue GH Zwitterionic sulfobetaine-grafted poly(vinylidene fluoride)
membrane with improved blood compatibility via atmospheric plasma-induced surface copolymerization ACS Appl
Mater Interfaces 201131228-37
[5] Shih YJ Chang Y Deratani A Damien Q Schizophrenic hemocompatible copolymers via switchable
thermoresponsive transition of nonioniczwitterionic block self-assembly in human blood Biomacromolecules
2012132849minus58
[6] Chang Y Shih YJ Lai CJ Kung HH Jiang S Ion-pair anchoring of self-assembled zwitterionic copolymer surfaces
with highly controlled blood compatibility Advanced Functional Materials 2013231100-10
13
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-2 Dr Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences
University of Tsukuba
Address Tennoudai 1-1-1 Tsukuba Ibaraki 305-8573 Japan
E-mailikedaimstsukubaacjp
Education March 1999 B S in Faculty of Engineering Kyoto University March 2001 MS in Graduate School of Engineering Department of Synthetic Chemistry and
Biological Chemistry Kyoto University March 2004 PhD in School of Engineering The University of Tokyo
Professional Experience 2004~2006 Advanced industrial science and technology (AIST) 2006~2008 Cytopathfinder Inc 2008~to date University of Tsukuba
Selected Publication (2010~) Y Ikeda J Katamachi H Kawasaki Y Nagasaki Novel protein PEGylation chemistry via glutalaldehydefunctionalized PEG Bioconjugate Chemistry 24 1824-1827 (2013) Y Ikeda D Kubota Y Nagasaki Design of sugar-oligonucleotide conjugates installed gold nanoparticle for effective delivery to hepatic parenchymal cells Colloid and Polymer Science 291 2959-2964 Y Ikeda H Kawasaki S Ichinohe Y Nagasaki Facile solid-phase synthesis of a highly stable poly(ethylene glycol)-oligonucleotide conjugate Journal of Materials Chemistry B 1 529-535(2013) Y Ikeda T Jomura U Horiuchi J Saeki K Yoshimoto T Ikeya Y Nagasaki Long-term survival and functional maintenance of hepatocytes by using a microfabricated cell array Colloid and Surface B Biointerface 97 97-100 2012 Y Ikeda Y Nagasaki PEGylation Technology in Nanomedicine Advances in Polymer Science 247 115-140 2012 Y Ikeda R Suzuki T Yoshitomi Y Nagasaki Novel oligonucleotide carrier possessing reactive oxygen species scavenging ability Macromolecular Bioscience 2011 11 344-351 Y Ikeda D Kubota Y Nagasaki Simple solid-phase synthesis and biological properties of carbohydrate-oligonucleotide conjugates modified at the 3rsquo terminus Bioconjugate Chem 2010 21 1685-1690
14
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-2 Sep 13 2014 (Sat) 0945-1015 at NTHU BMES R120
Chemical Modifications for the Developments of Next Generation Drugs
Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences University of
Tsukuba
Controlling of biodistribution and PKPD is a key issue for the development of drugsVariety of
technologies have been reported to improve those properties Those technologies include
nanoparticle formulation and PEGylation technology In my presentation I will show recent
chemical modification technologies which we developed to improve PKPD and distribution of
drugs
A novel chemistry for the PEGylated protein with a high activity
Several PEGylated proteins have been approved as therapeutic drugs In many cases PEGylated
protein has been synthesized by the conjugation reaction between PEG possessing activated ester and
amine(s) in the protein This reaction however often causes inactivation of PEGylated proteins In
this report we present a novel chemistry which enables the PEGylation of proteins under the mild
reaction condition PEGylated lysozyme prepared by the method developed increased the biological
activity of the PEGylated lysozyme more than 20 times compared with the PEGylated lysozyme
prepared by the conventional method
Design and development of novel hypoxically activated prodrugs
Tumor hypoxia is well known to promote mutagenesis invasiveness and to be associated with a
worse prognosis Although the treatment of the tumor hypoxia has been highly demanded resistance
to radiotherapy and anticancer chemotherapy have been serious problems The object of this study
was the development of hypoxically activated prodrugs which accumulate and act on cells at hypoxic
region of tumor Several conventional anti-cancer drugs including doxorubicin gemcitabine and 5FU
have been modified with 2-nitro imidazole derivative This modification enabled inactivation of drug
to reduce adverse effects under the normoxia condition and selective activation of prodrug under the
hypoxic condition
15
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-3 Prof Tzu-Wei Wang
Associate Professor
Department of Materials Science and Engineering and Institute of Biomedical
Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013
Office Delta Teaching Building R434
TEL +886-3-5715131 ext 33856
Email twwangmxnthuedutw Education 2006 PhD Institute of Biomedical Engineering National Taiwan University Taiwan
Professional Experience 2013 ndashpresent Associate Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2009 -2013 Assistant Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2007-2009 Postdoctoral Research Fellow Tissue Engineering Laboratories of Brigham and Womenrsquos
Hospital Harvard Medical School USA
Honor and awards (2009~) Young Plenary Award 2013 TERMIS-AP Symposium Shanghai China (2013) The 9th National Innovation Award Academic Research Category by Institute for Biotechnology and Medicine Industry Taiwan (2012) Young Investigator Award International Symposium of Materials on Regenerative Medicine Taiwan (2012 ISOMRM) Young Investigator Award 5th World Congress on Bioengineering the World Association for Chinese Biomedical Engineers Taiwan (WACBE 2011)
Selected Publication (2012~) Yang CS Wu HC Sun JS Hsiao HM Wang TW Thermo-induced shape memory PEG-PCL copolymer as dual drug-eluting biodegradable stent ACS Appl Mater Interfaces 2013 5 (21) 10985ndash10994 Yeh PH Sun JS Wu HC Hwang LH Wang TW Stimuli-responsive HA-PEI nanoparticles encapsulating endostatin plasmid for stem cell gene therapy RSC Advances 2013 3 (31) 12922 - 12932 Chen YY Wu HC Sun JS Dong GC Wang TW Injectable and thermoresponsive self-assembled nanocomposite hydrogel for long-term anticancer drug delivery Langmuir 201329(11)3721-3729 Cheng TY Wu HC Chang WH Huang MY Lee CH Wang TW Self-assembling functionalized nanopeptides for immediate hemostasis and accelerative liver tissue regeneration Nanoscale 2013 5 (7) 2734 - 2744 Chang YJ Tsai CJ Tseng FG Chen TJ Wang TW Micropatterned Stretching System for the Investigation of Mechanical Tension on Neural Stem Cells Behavior Nanomedicine Nanotechnology Biology and Medicine 20139345-355 Cheng TY Chen MH Chang WH Huang MY Wang TW Neural stem cells encapsulated in a functionalized self-assembling peptide hydrogel for brain tissue engineering Biomaterials 2013 34(8)2005-2016 Goh JH Wu HC Chen MH Chen MY Chang SC Wang TW Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages Acta Biomaterialia 20139(2)5170-5180 Huang YJ Wu HC Tai NH Wang TW Carbon Nanotube Rope with Electrical Stimulation Promotes the Differentiation and Maturity of Neural Stem Cells Small 20128(18) 2869ndash2877
16
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-3 Sep 13 2014 (Sat) 1015-1045 at NTHU BMES R120
Electrospun Composite Nanofibers with Staged Release of Multiple Angiogenic Growth Factors for Chronic Wound Healing
Tzu-Wei Wang
Department of Materials Science and Engineering and Institute of Biomedical Engineering National
Tsing Hua University
The objective of this research study is to develop collagen (Col) and hyaluronic acid (HA)
inter-stacking nanofibrous skin equivalent substitute with programmable release of multiple
angiogenic growth factors (VEGF PDGF bFGF and EGF) either directly embedded in the
nanofibers or encapsulated in the gelatin nanoparticles (GN) by electrospinning technology The
delivery of EGF and bFGF in early stage is expected to accelerate epithelialization and vasculature
sprouting while release of PDGF and VEGF in late stage is aimed for the induction of blood vessels
maturation The physiochemical characterizations report that the Col-HA-GN nanofibrous membrane
possesses mechanical property similar to human native skin The design of particle-in-fiber structure
allows growth factors for slow controlled release up to one month Cultured on biodegradable
Col-HA membrane with four kinds of growth factors (Col-HA w4GF) endothelial cells not only
increase in growth rate but also form better network of thread-like tubular structure Therapeutic
effect of Col-HA w4GF membrane on STZ-induced diabetic rats reveal accelerated wound closure
rate elevated collagen deposition and enhanced mature vessels by Massonrsquos trichrome stain and
immunohistochemical analysis respectively From the above the electrospun Col-HA-GN composite
nanofibrous skin substitute with stage-wise release pattern of multiple angiogenic factors could be a
promising bioengineered construct for the chronic wound healing in skin tissue regeneration
17
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-4 Assistant Prof Ryo Ishihara
Assistant Professor
Department of Materials Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
Tokyo University of Science Research Building 9th floor
TEL +81-3-5876-1415
FAX +81-3-5876-1415
Education 2012 PhD Department of Applied Chemistry and Biotechnology Chiba University Japan 2008 MS Department of Materials Technology Chiba University Japan 2006 BS Department of Materials Technology Chiba University Japan
Professional Experience 2014 ndashpresent Assistant Professor Department of Materials Science and Technology Tokyo
University of Science 2012 ndash2014 Postdoctral Researcher Bioengineering Laboratory RIKEN
Honor and awards Department chairmanlsquos award from Chiba University (2012)
Selected Publication (2010~) Simple Method for High-Density Impregnation of Aliquat 336 onto Porous Sheet and Binding Performance of Resulting Sheet for Palladium Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota Sep Sci Technol 49154-159 (2014) Effect of Dose on Mole Percentage of Polymer Brush and Root Grafted onto Porous Polyethylene Sheet by Radiation-Induced Graft Polymerization R Ishihara S Uchiyama H Ikezawa S Yamada H Hirota D Umeno K Saito Ind Eng Chem Res 5212582-12586 (2013) Determination of Mole Percentages of Brush and Root of Polymer Chain Grafted onto Porous Sheet S Uchiyama R Ishihara D Umeno K Saito S Yamada H Hirota S Asai J Chem Eng Japan 46414-419 (2013) Crosslinked-chelating Porous Sheet with High Dynamic Binding Capacity of Metal Ions G Wada R Ishihara K Miyoshi D Umeno K Saito S Yamada H Hirota Solv Extr Ion Exch 31210-220 (2013) Dependence of Lanthanide-Ion Binding Performance on HDEHP Concentration in HDEHP Impregnation to Porous Sheet R Ishihara S Asai S Otosaka S Yamada H Hirota K Miyoshi D Umeno K Saito Solv Extr Ion Exch 30171-180 (2012) Impregnation of TOPO onto Hydrophobic-Ligand-Containing Porous Sheet and Its Adsorptionelution Performance of Bismuth Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota React Funct Polym 70986-990 (2010)
18
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-4 Sep 13 2014 (Sat) 1110-1140 at NTHU BMES R120
Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip toward Point-of-Care Diagnosis
Ryo Ishihara Kazuo Hosokawa Mizuo Maeda
Bioengineering Laboratory RIKEN
MicroRNAs (miRNAs) are short and non-protein-coding single-stranded RNAs and have shown great promise for
cancer diagnosis Some miRNAs circulate in human body fluid with extremely low concentrations and its expression
profiling can detect and classify cancers in the human body [1] Point-of-care (POC) diagnosis requires short detection
time small required sample volume and portability of the device In various miRNA detection methods microfluidic
chip meets the requirements except the portability Hence we used our power-free pump-free microfluidic chip driven
by energy that is stored in degased PDMS to overcome those drawbacks which eliminates the need for external power
sources for fluid pumping [2] The pump-free pumping method is essential for microfluidic chip-based POC diagnosis In
our laboratory rapid and sensitive singleplex miRNA detection with laminar flow-assisted dendritic amplification (LFDA)
[3] on the pump-free microfluidic chip has been developed [4] In this study rapid and sensitive multiplex miRNA
detection on the pump-free microfluidic chip was demonstrated
Pump-free microchip for multiplex miRNA detection was prepared as follows First the PDMS part with a pair of
Y-shaped microchannels with 100 μm in width and 25 μm in height was fabricated Second three parallel-line-shaped
probe DNAs were patterned onto a glass surface Third the PDMS channels were attached onto the glass plate Finally
the chip was degassed in a vacuum chamber After the chip preparation target miRNAs were detected following three
steps (1) blocking (2) sandwich hybridization of the target miRNAs and biotinylated probe DNAs and (3) signal
amplification by LFDA MiR-16 miR-21-5p and miR-500a-3p were used as target miRNAs since they are known as
cancer biomarkers [5-7] Fluorescence signals were captured by CCD camera and analyzed by the software (ImageJ)
Bright lines appeared at the expected positions they appeared only on the areas with the respective probe DNA in which
the target miRNAs had been supplied These data prove that the LFDA successfully took place in a target
sequence-dependent manner Calibration curves were plotted from the fluorescence signals The data points of the
calibration curve were fitted with the four-parameter logistic function and limit-of-detections (LODs) were evaluated by
the 3σ criterion LODs of the miR-16 miR-21-5p and miR-500a-3p were 68 fM 15 pM and 150 fM respectively The
LODs are on the same order of magnitude as concentrations of miRNA in blood Multiplex detection was verified from
correspondence between the calibration curves of single and multiplex The required sample volume was 05 microL and
assay time was 20 min Because most of the existing methods take more than a few hours the rapidness small required
sample volume and portability of the device are ideal advantages for POC diagnosis
References
[1] PS Mitchell et al PNAS 105 (2008) 10513 [2] K Hosokawa et al Lab Chip 4 (2004) 181 [3] K Hosokawa et al Anal
Chem 79 (2007) 6000 [4] H Arata et al PLoS ONE 7 (2012) e48329 [5] MJ Lodes et al PLoS ONE 4 (2009) e6229
[6] Y Toiyama et al J Natl Cancer Inst 105 (2013) 849 [7] Y Yamamoto et al Biomarkers 14 (2009) 529
19
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-5 Dr Wen-Hsuan Chiang
Assistant Researcher
Department of Biomedical Engineering and Environmental Sciences
National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
TEL (886) 3-571-5131 ext 35576
Education 2009 PhD Department of Chemical Engineering National Chung Hsing University Taiwan Thesis Supervisor Professor Hsin-Cheng Chiu 2002 BS Department of Chemical Engineering Tatung University Taiwan Professional Experience 2013 ndashpresent Assistant Researcher Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University 2010 ndash2012 Postdoctoral Fellow Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
Areas of Research Expertise Biomaterials Smart Amphiphilic Copolymers Multifunctional Nanocarriers for Cancer Therapy and Imaging Nano Science and Interfacial Engineering
Selected Publication (2010~) Wen-Hsuan Chiang Wen-Chia Huang Ming-Yin Shen Che-Hsu Wang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Dual-Layered Nanogel-Coated Hollow LipidPolypeptide Conjugate Assemblies for Potential pH-Triggered Intracellular Drug Release PLOS ONE 2014 9 1-11 Wen-Hsuan Chiang Wen-Chia Huang Chien-Wen Chang Ming-Yin Shen Zong-Fu Shih Yi-Fong Huang Sung-Chyr Lin Hsin-Cheng Chiu Functionalized Polymersomes with Outlayered Polyelectrolyte Gels for Potential Tumor-Targeted Delivery of Multimodal Therapies and MR Imaging Journal of Controlled Release 2013 168 280-288 Wen-Hsuan Chiang Viet Thang Ho Hsin-Hung Chen Wen-Chia Huang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Superparamagnetic Hollow Hybrid Nanogels as a Potential Guidable Vehicle System of Stimuli-Mediated MR Imaging and Multiple Cancer Therapeutics Langmuir 2013 29 6434-6443 Wen-Hsuan Chiang Viet Thang Ho Wen-Chia Huang Yi-Fong Huang Chorng-Shyan Chern Hsin-Cheng Chiu Dual Stimuli-Responsive Polymeric Hollow Nanogels Designed as Carriers for Intracellular Triggered Drug Release Langmuir 2012 28 15056-15064 Yi-Fong HuangDagger Wen-Hsuan ChiangDagger Pei-Ling Tsai Chorng-Shyan Chern Hsin-Cheng Chiu Novel Hybrid Vesicles Co-Assembled from Cationic Lipid and PAAc-g-mPEG with pH-Triggered Transmembrane Channels for Controlled Drug Release Chemical Communications 2011 47 10978-10980
20
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-5 Sep 13 2014 (Sat) 1140-1210 at NTHU BMES R120 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and Imaging
Applications
Wen-Hsuan Chiang
Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
In order to promote therapeutic efficacy and minimize side effect equipping these nanocarriers with the
capability of controlling drug release in response to an appropriate stimulus is essentially required Acidic pH
as an internal stimulus is particular appealing because of the mildly acid pH encountered in tumor tissues and
the intracellular compartments such as endosomes and lysosomes Therefore the pH-responsive drug carriers
have been extensively developed for improving intracellular drug delivery To realize the pH-responsive drug
release we adopted a simple approach to design the lipidPEG-containing complex vesicles with pH-triggered
transmembrane channels as a chemotherapy drug doxorubicin (DOX) delivery carrier In this study the
complex vesicles were attained by spontaneous co-assembly of poly(acrylic acid)-g-poly(monomethoxy
ethylene glycol) (PAAc-g-mPEG) with a cationic lipid didodecyldimethylammonium bromide (DDAB) in
aqueous phase of pH 89 via electrostatic interactions Through the formation of unionized AAc-rich
transmembrance channels of complex vesicles in weak acidic environments the acid-triggered rapid drug
release can be achieved
On the other hand for simultaneously monitoring disease progression and biological response after
treatments we developed a novel tumor-targeting polymersome system capable of delivering magnetic
resonance imaging (MRI) and chemotherapy The DOX-loaded magnetic polymersomes were first attained by
the self-assembly of lipid-containing copolymer poly(AAc-co-distearin acrylate) in aqueous solution
containing citric acid-coated superparamagnetic iron oxide nanoparticles (SPIONs) and followed by DOX
loading via electrostatic attraction To further functionalize these vesicles with superior in vivo colloidal
stability pH-tunable drug release and active tumor-targeting chitosan and poly( -glutamic
acid-co- -glutamyl oxysuccinimide)-g-PEG-folate (FA) were deposited in sequence onto the assembly outer
surfaces The interfacial nanogel layers via electrostatic interactions and in-situ covalent cross-linking were
thus produced Triggerable release of the encapsulated DOX was governed by dual external stimuli pH and
temperature When these theranostic NCPs were effectively internalized by HeLa cells via FA
receptor-mediated endocytosis and then exposed to high frequency magnetic fields (HFMF) the combined
effects of both pH and magnetic hyperthermia-triggered drug release and thermo-therapy resulted in greater
cytotoxicity than the treatment by DOX alone By virtue of the SPION clustering effect in the assembly inner
aqueous compartments the SPIONDOX-loaded NCPs displayed an r2 relaxivity value higher than Resovist
a commercial SPION-based T2 contrast agent The high magnetic relaxivity of the tumor-targeting NCPs
coupled with their enhanced cellular uptake considerably promoted the MRI contrast of targeted cancer cells
These results demonstrate the great potential of the FA-decorated SPIONDOX-loaded NCPs as an advanced
cancer theranostic nanodevice
21
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-1 Prof Hao-Li Liu Professor and Director
Department of Electrical Engineering
Chang Gung University
Phone +886-3-2118800 ext 5677
Fax +886-3-2118026
E-mail haoliliumailcguedutw
Education 2003 PhD National Taiwan University Taipei TAIWAN 1998 M S National Taiwan University Taipei TAIWAN 1996 B S National Taipei University of Technology TAIWAN
Professional Experience 2012-present Director Dept of Electrical Engineering Chang Gung Univ Taiwan 2011-present Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2008 Associate Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2005 ndash2008 Assistant Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2004 ndash2005 Research Fellow Department of Radiology Brigham amp Womenrsquos Hospital Harvard Medical School MA USA
Honor and awards (2009~) 2013 Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) 2013 The 2013 Frederick Lizzi Award International Society of Therapeutic Ultrasound 2011 Distinguished Tech-Coop Award (長庚大學優良教師技合獎) Chang-Gung University 2011 Wu Ta-You Memorial Award (吳大猷先生紀念獎) National Science Council Taiwan 2011 2010 Distinguished Research Award (長庚大學優良教師研究獎) Chang-Gung University
Selected Publication (2010~) HW Yang MY Hua TL Hwang KJ Lin CY Huang RY Tsai CCM Ma PH Hsu SP Wey PW Hsu PY Chen YC Huang YJ Lu TC Yen LY Feng CW Lin HL Liu KC Wei Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide Advanced Materials Vol 25 No 26 pp3605-3611 2013 HL Liu CH Fan CY Ting and CK Yeh Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors Theranostics Vol 4 No 4 pp432-444 2014 KC Wei PC Chu HYJ Wang CY Huang PY Chen HC Tsai YJ Lu IC Tseng PY Lee TC Yen and HL Liu Focused Ultrasound-induced BloodndashBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment A Preclinical Study PLoS ONE Vol 8 No 3 pp e58995 2013 P-H Hsu K-C Wei C-Y Huang C-J Wen T-C Yen C-L Liu Y-T Lin J-C Chen C-R Shen and H-L Liu Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound PLoS ONE Vol 8 No 2 pp e57682 2013 H-L Liu M-Y Hua H-W Yang C-Y Huang P-C Chu J-S Wua I-C Tseng J-J Wang T-C Yen P-Y Chen and K-C Wei ldquoMagnetic resonance monitoring of focused ultrasoundmagnetic nanoparticle targeting delivery of therapeutic agents to the brainrdquo Proceedings of National Academy of Science USA Vol 107 No 34 pp15205-15210 2010 H-L Liu M-Y Hua P-Y Chen P-C Chu C-H Pan H-W Yang C-Y Huang J-J Wang T-C Yen and K-C Wei ldquoBloodndashBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatmentrdquo Radiology Vol 255 No 2 pp 415-425 2010 H-L Liu Y-Y Wai P-H Hsu L-A Lyu J-S Wu C-R Shen J-C Chen T-C Yen and J-J Wang ldquoIn Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Bloodndashbrain Barrier with Focused Ultrasound A Magnetic Resonance Imaging Studyrdquo Journal of Cerebral Blood Flow amp Metabolism Vol 30 pp 168-177 2010
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
3
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Information
Date September 12-15 2014
Venue Department of Biomedical Engineering and Environmental Sciences National Tsing
Hua University No 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
Website httppt-bmeswebnodetw
Notice for Presenting Authors The full poster abstract download will be available on Sept
12th 2014 on symposium website The attendee are recommended to download the PDF file to
your computer or your pad device
ABSTRACT SUBMISSION
Poster sessions
bull Session A Biomaterials
bull Session B Biomedical Imaging
bull Session C Science and Technology for Environment amp Energy
4
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Committee
Organizing Chair Prof Chi-Shiun Chiang Chairman BMES NTHU Taiwan
Organizing Co-Chair Prof Kohei SOGA PTRC TUS Japan
Symposium Secretariat Prof Shang-Hsiu Hu BMES NTHU Taiwan
Local Organizing Committee Prof Ruey-An Doong NTHU Taiwan
Prof Hsin-Cheng Chiu NTHU Taiwan
Prof Chih-Kuang Yeh NTHU Taiwan
Prof Yu-Fen Huang NTHU Taiwan
Dr Wen-Hsuan Chiang NTHU Taiwan
Prof Tzu-Wei Wang NTHU Taiwan
Prof Chien-Wen Chang NTHU Taiwan
Prof Yuh-Chang Sun NTHU Taiwan
Prof Fu-Nien Wang NTHU Taiwan
Prof Hsu-Hsia Peng NTHU Taiwan
Contact Prof Shang-Hsiu Hu NTHU Taiwan
Email address shhumxnthuedutw
5
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
List of Session Chairperson
Session A Biomaterials Prof Ryo Ishihara (石原量 ) (Professor Dept of Materials Science and Technology Tokyo
University of Science Japan)
Prof Hsin-Cheng Chiu (邱信程) (Professor Dept of Biomedical Engineering and Environmental
Sciences National Tsing Hua University)
Session B Biomedical Imaging Prof Chih-Kuang Yeh (葉秩光) (Professor Dept of Biomedical Engineering and Environmental
Sciences National Tsing Hua University)
Prof Kohei Soga (曽我公平) (Professor Dept of Materials Science and Technology Tokyo
University of Science Japan)
Session C Science and Technology for Environment amp Energy Prof Yu-Fen Huang (黃郁棻) (Professor Dept of Biomedical Engineering and Environmental
Sciences National Tsing Hua University)
Prof Keishi Nishio ( 西 尾 圭 史 ) (Professor Dept of Materials Science and Technology
University of Tsukuba)
6
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
List of Invited Speaker
Session A Biomaterials Prof Yung Chang (張雍) (Professor Dept of Chemical Engineering Chung Yuan University)
Prof Yutaka Ikeda (池田豊) (Professor Dept of Mater Sci University of Tsukuba Japan)
Prof Tzu-Wei Wang (王子威) (Professor Dept of Materials Science and Engineering National
Tsing Hua University)
Prof Ryo Ishihara (石原量) (Assistant Professor Dept of Materials Science and Technology
University of Tsukuba Japan)
Dr Wen-Hsuan Chiang (姜文軒) (Assistant Researcher Dept of Biomedical Engineering and
Environmental Sciences National Tsing Hua University)
Session B Biomedical Imaging Prof Hao-Li Liu (劉浩澧) (Dept of Electrical Engineering Chang Gung University Taiwan)
Dr Ichio Aoki (青木伊知男) (Molecular Imagining Center National Institute of Radiological
Sciences Japan)
Prof Meng-Lin Li (李夢麟) (Associate Professor Dept of Electrical Engineering National Tsing
Hua University)
Prof Tomoko Masaike (政池知子) (Associate Professor Tokyo University of Science Japan)
Prof Chih-Chung Huang(黃執中 ) (Assistant Professor Dept of Biomedical Engineering
National Cheng Kung University)
Prof Masao Kamimura ( 上村真生 ) (Assistant Professor Dept of Materials Science and
Technology University of Tsukuba Japan)
Session C Science and Technology for Environment amp Energy Prof Keishi Nishio (西尾圭史 ) (Professor Dept of Materials Science and Technology
University of Tsukuba)
Prof Hsing-Cheng Hsi (席行正) (Associate Professor Graduate Institute of Environmental
Engineering National Taiwan University)
Prof Kenjiro Fujimoto(藤本憲次郎 )(Department of Pure and Applied Chemistry Tokyo
University of Science)
Prof Fu-Hsiang Ko (柯富祥) (Professor Institute of Nanotechnology National Chiao Tung
University)
Prof Naoto Kitamura (北村尚斗 ) (Associate Professor Department of Pure and Applied
Chemistry Tokyo University of Science)
Prof Zong-Hong Lin (林宗宏 ) (Assistant Professor Institute of Biomedical Engineering
National Tsing Hua University)
7
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Organizer
Department of Biomedical Engineering and Environmental Sciences (BMES)
National Tsing HuaUniversity (NTHU) Taiwan
清華大學 生醫工程與環境科學系
Department of Materials Science and Technologies
Tokyo University of Science (TUS) Japan
東京理科大學 材料科學與技術系
Co-Organizer
Engineering and Technology Promotion Center
National Science Council (NSC) Taiwan
國家科學委員會 工程科技推展中心
College of Nuclear Science
National Tsing Hua Univeristy (NTHU) Taiwan
清華大學 原子科學院
8
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Map
9
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Program
September 12 (Fri) 2014
Time Agenda Speaker
1900~2100 Welcome and Opening Ceremony (Hall of Fame)
September 13 (Sat) 2014 Place NTHU BMES
Time Agenda Speaker
0830~0900 Registration (Entrance Hall NTHU BMES)
0900~0915 Opening Remarks Symposium Chairs
Session A Biomaterials Moderator Hsin-Cheng Chiu (NTHU) Ryo Ishihara (TUS)
0915~0945 Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes (Keynote)
Prof Yung Chang張
雍
0945~1015 Chemical Modifications for the Developments of Next Generation
Drugs (Keynote)
Prof Yutaka Ikeda
池田豊
1015~1045 Electrospun Composite Nanofibers with Staged Release of Multiple
Angiogenic Growth Factors for Chronic Wound Healing (Keynote)
Prof Tzu-Wei Wang
王子威
1045~1110 Break
1110~1140 Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip
toward Point-of-Care Diagnosis (invited)
Prof Ryo Ishihara石
原量
1140~1210 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and
Imaging Applications (Invited)
Dr Wen-Hsuan
Chiang姜文軒
1200~1330 Lunch
Session B Biomedical Imaging Moderator Chih-Kuang Yeh (NTHU) Kohei Soga (TUS)
1320~1400 Focused-Ultrasound Brain-Drug Delivery Approach and
Application (Keynote)
Prof Hao-Li Liu劉
浩澧
1400~1440 Responsive and Theranostic Nano-Contrast Agents for Preclinical
MR Imaging (Keynote)
Dr Ichio Aoki青木
伊知男
1440~1510 Observation of Single-Molecule Enzymes through Probes under the
Optical Microscope (Keynote)
Prof Tomoko
Masaike政池知子
1510~1630 Break
1630~1710 Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing
SPIO Nanoparticles Ultrasonically (Invited)
Prof Meng-Lin Li
李夢麟
1710~1740 High resolution ultrasound elastography for medical applications
(Invited)
Prof Chih-Chung
Huang黃執中
1740~1810 Biofunctional Polymers for Application of Ceramic Nanoparticles
for Fluorescence Bioimaging (Invited)
Prof Masao
Kamimura上村真生
1900~ Banquet (合口味)
10
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
September 14 (Sun) 2014 Place NTHU BMES
Time Agenda Speaker
0845~0900 Registration
Session C Science and Technology for Environment amp Energy
Moderator Yu-Fen Huang (NTHU) Keishi Nishio (TUS)
0900~0930 Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed
Tungsten Oxide Thin Films for Hydrogen Gas Sensor (Keynote)
Prof Keishi Nishio
西尾圭史
0930~1000 Control of low-concentration gaseous mercury from stationary
sources via adsorption and oxidation (Keynote)
Prof Hsing-Cheng
His席行正
1000~1030 High-Throughput Functional Materials Exploration by
Combinatorial WetDry Process (Keynote)
Prof Kenjiro
Fujimoto藤本憲次
郎
1030~1050 Break
1050~1120 Facile Manufacturing on Energy-efficient Devices with Flexibility
and Antireflection (Invited)
Prof Fu-Hsiang Ko
柯富祥
1120~1150 Proton Distribution and Dynamics in BaZrO3-Based Proton
Conductor for Solid Oxide Fuel Cell (Invited)
Prof Naoto
Kitamura北村尚斗
1150~1220 Harvesting Water Energy by a Sequential Contact-Electrification and
Electrostatic-Induction Process (Invited)
Prof Zong-Hong
Lin林宗宏
1210~1330 Lunch
Poster Session
1330~1530 Poster Session
1600~1800 Move to I-Lan
1800~2000 Luodong Night Market
2000 National Center for Traditional Art I-Lan (宜蘭傳藝)
September 15 (Mon) 2014 Place I-Lan
Time Agenda Speaker
0700~0800 Breakfast
0845~0910 Closing Remarks
(National Center for Traditional Art I-Lan)
0910~1500 Visit National Center for Traditional Art
1150~1330 Lunch
1530 Move to Taipei Railway Station or Hsinchu
11
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker
Invited Speaker A-1 Prof Yung Chang
Distinguished Professor
Department of Chemical Engineering
Deputy Director RampD Center for Membrane Technology
Chung Yuan Christian University
Address Jhong-Li Taoyuan 320 Taiwan
TEL (886) 265-4122
FAX (886) 265-4190
Education 2004 PhD Chemical Engineering National Taiwan University Taiwan 2000 MS Chemical Engineering National Taiwan University Taiwan 1998 BS Chemical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013-present Deputy Director RampD Center for Membrane Technology Chung Yuan Christian
University 2013-present Distinguished Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2013-present Professor Department of Chemical Engineering Chung Yuan Christian University
Taiwan 2009-2013 Associate Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2006-2009 Assistant Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2005-2006 Postdoctoral Fellow Chemical Engineering University of Washington USA 2004-2005 Postdoctoral Fellow Chemical Engineering National Taiwan University Taiwan
Honor and awards (2010~) 2010 Yung Investigator Award of Chemical Engineering (Taiwan Institute of Chemical Engineers) 2010 Yung Investigator Award of Materials on Regenerative Medicine (National Health Research
Institutes Taiwan) 2011 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan) 2011 Outstanding Research Award of Chemical Engineering (LCY Chemical Corp) 2012 NSC Wu Da-Yu Award (National science council Taiwan) 2012 NSC Outstanding AcademicIndustrial Cooperation Award (National science council) 2013 Yung Investigator Award of Polymer Science (Taiwan Institute of Polymer Science) 2013 JCS The Distinguished Lectureship Award Biomaterial Research (Japan Chemical Society) 2013 Ukraine International Invention Exhibition Gold Medal (Ukraine Invention Society) 2014 Pittsburgh International Invention Exhibition Gold Medal (USA Invention Society) 2014 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan)
12
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-1 Sep 13 2014 (Sat) 0915-0945 at NTHU BMES R120
Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes
Chung Yuan
RampD Center for Membrane Technology and Department of Chemical Engineering Christian
University Chung-Li Taoyuan 320 Taiwan
Zwitterionic polymeric interface resisting the adsorption of plasma proteins is important in the
development of blood-contacting biomaterials in such applications as blood collection devices
antithrombogenic implants hemodialysis membranes drug-delivery carriers and diagnostic
biosensors Previous studies showed that the control of surface charge neutrality is important for a
zwitterionic surface with effective protein-resistant properties Importantly it was further reported
that the mixed-charge formulation in self-assembled monolayers copolymer hydrogels and
polymeric brushes provide a new avenue to achieve nonfouling surfaces with the prevention of
nonspecific protein adsorption if the charge balance can be well controlled This talk will cover three
major studies
Bio-inert nature of biomimetic zwitterionicpseudozwitterionic structures
Blood-Inert
Surfaces via ion-pair anchoring of zwitterionic copolymer brushes in human whole blood Surface
zwitterionization of membrenaes in novel biomedical applications
[1] Chang Y Liao SC Higuchi A Ruaan RC Chu CW Chen WY A highly stable nonbiofouling surface with
well-packed grafted zwitterionic polysulfobetaine for plasma protein repulsion Langmuir 2008245453-58
[2] Chiag YC Chang Y Higuchi A Chen WY Ruaan RC Sulfobetaine-grafted poly(vinylidene fluroride) ultrafiltration
membranes exhibit excellent antifouling property Journal of Membrane Science 2009339151-9
[3] Chang Y Yandi W Chen WY Shih YJ Yang CC Chang Y Ling QD Higuchi A Tunable bioadhesive copolymer
hydrogels of thermoresponsive poly(N-isopropyl acrylamide) containing zwitterionic polysulfobetaine
Biomacromolecules 2010111101-10
[4] Chang Y Chang WJ Shih YJ Wei TC Hsiue GH Zwitterionic sulfobetaine-grafted poly(vinylidene fluoride)
membrane with improved blood compatibility via atmospheric plasma-induced surface copolymerization ACS Appl
Mater Interfaces 201131228-37
[5] Shih YJ Chang Y Deratani A Damien Q Schizophrenic hemocompatible copolymers via switchable
thermoresponsive transition of nonioniczwitterionic block self-assembly in human blood Biomacromolecules
2012132849minus58
[6] Chang Y Shih YJ Lai CJ Kung HH Jiang S Ion-pair anchoring of self-assembled zwitterionic copolymer surfaces
with highly controlled blood compatibility Advanced Functional Materials 2013231100-10
13
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-2 Dr Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences
University of Tsukuba
Address Tennoudai 1-1-1 Tsukuba Ibaraki 305-8573 Japan
E-mailikedaimstsukubaacjp
Education March 1999 B S in Faculty of Engineering Kyoto University March 2001 MS in Graduate School of Engineering Department of Synthetic Chemistry and
Biological Chemistry Kyoto University March 2004 PhD in School of Engineering The University of Tokyo
Professional Experience 2004~2006 Advanced industrial science and technology (AIST) 2006~2008 Cytopathfinder Inc 2008~to date University of Tsukuba
Selected Publication (2010~) Y Ikeda J Katamachi H Kawasaki Y Nagasaki Novel protein PEGylation chemistry via glutalaldehydefunctionalized PEG Bioconjugate Chemistry 24 1824-1827 (2013) Y Ikeda D Kubota Y Nagasaki Design of sugar-oligonucleotide conjugates installed gold nanoparticle for effective delivery to hepatic parenchymal cells Colloid and Polymer Science 291 2959-2964 Y Ikeda H Kawasaki S Ichinohe Y Nagasaki Facile solid-phase synthesis of a highly stable poly(ethylene glycol)-oligonucleotide conjugate Journal of Materials Chemistry B 1 529-535(2013) Y Ikeda T Jomura U Horiuchi J Saeki K Yoshimoto T Ikeya Y Nagasaki Long-term survival and functional maintenance of hepatocytes by using a microfabricated cell array Colloid and Surface B Biointerface 97 97-100 2012 Y Ikeda Y Nagasaki PEGylation Technology in Nanomedicine Advances in Polymer Science 247 115-140 2012 Y Ikeda R Suzuki T Yoshitomi Y Nagasaki Novel oligonucleotide carrier possessing reactive oxygen species scavenging ability Macromolecular Bioscience 2011 11 344-351 Y Ikeda D Kubota Y Nagasaki Simple solid-phase synthesis and biological properties of carbohydrate-oligonucleotide conjugates modified at the 3rsquo terminus Bioconjugate Chem 2010 21 1685-1690
14
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-2 Sep 13 2014 (Sat) 0945-1015 at NTHU BMES R120
Chemical Modifications for the Developments of Next Generation Drugs
Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences University of
Tsukuba
Controlling of biodistribution and PKPD is a key issue for the development of drugsVariety of
technologies have been reported to improve those properties Those technologies include
nanoparticle formulation and PEGylation technology In my presentation I will show recent
chemical modification technologies which we developed to improve PKPD and distribution of
drugs
A novel chemistry for the PEGylated protein with a high activity
Several PEGylated proteins have been approved as therapeutic drugs In many cases PEGylated
protein has been synthesized by the conjugation reaction between PEG possessing activated ester and
amine(s) in the protein This reaction however often causes inactivation of PEGylated proteins In
this report we present a novel chemistry which enables the PEGylation of proteins under the mild
reaction condition PEGylated lysozyme prepared by the method developed increased the biological
activity of the PEGylated lysozyme more than 20 times compared with the PEGylated lysozyme
prepared by the conventional method
Design and development of novel hypoxically activated prodrugs
Tumor hypoxia is well known to promote mutagenesis invasiveness and to be associated with a
worse prognosis Although the treatment of the tumor hypoxia has been highly demanded resistance
to radiotherapy and anticancer chemotherapy have been serious problems The object of this study
was the development of hypoxically activated prodrugs which accumulate and act on cells at hypoxic
region of tumor Several conventional anti-cancer drugs including doxorubicin gemcitabine and 5FU
have been modified with 2-nitro imidazole derivative This modification enabled inactivation of drug
to reduce adverse effects under the normoxia condition and selective activation of prodrug under the
hypoxic condition
15
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-3 Prof Tzu-Wei Wang
Associate Professor
Department of Materials Science and Engineering and Institute of Biomedical
Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013
Office Delta Teaching Building R434
TEL +886-3-5715131 ext 33856
Email twwangmxnthuedutw Education 2006 PhD Institute of Biomedical Engineering National Taiwan University Taiwan
Professional Experience 2013 ndashpresent Associate Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2009 -2013 Assistant Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2007-2009 Postdoctoral Research Fellow Tissue Engineering Laboratories of Brigham and Womenrsquos
Hospital Harvard Medical School USA
Honor and awards (2009~) Young Plenary Award 2013 TERMIS-AP Symposium Shanghai China (2013) The 9th National Innovation Award Academic Research Category by Institute for Biotechnology and Medicine Industry Taiwan (2012) Young Investigator Award International Symposium of Materials on Regenerative Medicine Taiwan (2012 ISOMRM) Young Investigator Award 5th World Congress on Bioengineering the World Association for Chinese Biomedical Engineers Taiwan (WACBE 2011)
Selected Publication (2012~) Yang CS Wu HC Sun JS Hsiao HM Wang TW Thermo-induced shape memory PEG-PCL copolymer as dual drug-eluting biodegradable stent ACS Appl Mater Interfaces 2013 5 (21) 10985ndash10994 Yeh PH Sun JS Wu HC Hwang LH Wang TW Stimuli-responsive HA-PEI nanoparticles encapsulating endostatin plasmid for stem cell gene therapy RSC Advances 2013 3 (31) 12922 - 12932 Chen YY Wu HC Sun JS Dong GC Wang TW Injectable and thermoresponsive self-assembled nanocomposite hydrogel for long-term anticancer drug delivery Langmuir 201329(11)3721-3729 Cheng TY Wu HC Chang WH Huang MY Lee CH Wang TW Self-assembling functionalized nanopeptides for immediate hemostasis and accelerative liver tissue regeneration Nanoscale 2013 5 (7) 2734 - 2744 Chang YJ Tsai CJ Tseng FG Chen TJ Wang TW Micropatterned Stretching System for the Investigation of Mechanical Tension on Neural Stem Cells Behavior Nanomedicine Nanotechnology Biology and Medicine 20139345-355 Cheng TY Chen MH Chang WH Huang MY Wang TW Neural stem cells encapsulated in a functionalized self-assembling peptide hydrogel for brain tissue engineering Biomaterials 2013 34(8)2005-2016 Goh JH Wu HC Chen MH Chen MY Chang SC Wang TW Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages Acta Biomaterialia 20139(2)5170-5180 Huang YJ Wu HC Tai NH Wang TW Carbon Nanotube Rope with Electrical Stimulation Promotes the Differentiation and Maturity of Neural Stem Cells Small 20128(18) 2869ndash2877
16
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-3 Sep 13 2014 (Sat) 1015-1045 at NTHU BMES R120
Electrospun Composite Nanofibers with Staged Release of Multiple Angiogenic Growth Factors for Chronic Wound Healing
Tzu-Wei Wang
Department of Materials Science and Engineering and Institute of Biomedical Engineering National
Tsing Hua University
The objective of this research study is to develop collagen (Col) and hyaluronic acid (HA)
inter-stacking nanofibrous skin equivalent substitute with programmable release of multiple
angiogenic growth factors (VEGF PDGF bFGF and EGF) either directly embedded in the
nanofibers or encapsulated in the gelatin nanoparticles (GN) by electrospinning technology The
delivery of EGF and bFGF in early stage is expected to accelerate epithelialization and vasculature
sprouting while release of PDGF and VEGF in late stage is aimed for the induction of blood vessels
maturation The physiochemical characterizations report that the Col-HA-GN nanofibrous membrane
possesses mechanical property similar to human native skin The design of particle-in-fiber structure
allows growth factors for slow controlled release up to one month Cultured on biodegradable
Col-HA membrane with four kinds of growth factors (Col-HA w4GF) endothelial cells not only
increase in growth rate but also form better network of thread-like tubular structure Therapeutic
effect of Col-HA w4GF membrane on STZ-induced diabetic rats reveal accelerated wound closure
rate elevated collagen deposition and enhanced mature vessels by Massonrsquos trichrome stain and
immunohistochemical analysis respectively From the above the electrospun Col-HA-GN composite
nanofibrous skin substitute with stage-wise release pattern of multiple angiogenic factors could be a
promising bioengineered construct for the chronic wound healing in skin tissue regeneration
17
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-4 Assistant Prof Ryo Ishihara
Assistant Professor
Department of Materials Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
Tokyo University of Science Research Building 9th floor
TEL +81-3-5876-1415
FAX +81-3-5876-1415
Education 2012 PhD Department of Applied Chemistry and Biotechnology Chiba University Japan 2008 MS Department of Materials Technology Chiba University Japan 2006 BS Department of Materials Technology Chiba University Japan
Professional Experience 2014 ndashpresent Assistant Professor Department of Materials Science and Technology Tokyo
University of Science 2012 ndash2014 Postdoctral Researcher Bioengineering Laboratory RIKEN
Honor and awards Department chairmanlsquos award from Chiba University (2012)
Selected Publication (2010~) Simple Method for High-Density Impregnation of Aliquat 336 onto Porous Sheet and Binding Performance of Resulting Sheet for Palladium Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota Sep Sci Technol 49154-159 (2014) Effect of Dose on Mole Percentage of Polymer Brush and Root Grafted onto Porous Polyethylene Sheet by Radiation-Induced Graft Polymerization R Ishihara S Uchiyama H Ikezawa S Yamada H Hirota D Umeno K Saito Ind Eng Chem Res 5212582-12586 (2013) Determination of Mole Percentages of Brush and Root of Polymer Chain Grafted onto Porous Sheet S Uchiyama R Ishihara D Umeno K Saito S Yamada H Hirota S Asai J Chem Eng Japan 46414-419 (2013) Crosslinked-chelating Porous Sheet with High Dynamic Binding Capacity of Metal Ions G Wada R Ishihara K Miyoshi D Umeno K Saito S Yamada H Hirota Solv Extr Ion Exch 31210-220 (2013) Dependence of Lanthanide-Ion Binding Performance on HDEHP Concentration in HDEHP Impregnation to Porous Sheet R Ishihara S Asai S Otosaka S Yamada H Hirota K Miyoshi D Umeno K Saito Solv Extr Ion Exch 30171-180 (2012) Impregnation of TOPO onto Hydrophobic-Ligand-Containing Porous Sheet and Its Adsorptionelution Performance of Bismuth Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota React Funct Polym 70986-990 (2010)
18
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-4 Sep 13 2014 (Sat) 1110-1140 at NTHU BMES R120
Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip toward Point-of-Care Diagnosis
Ryo Ishihara Kazuo Hosokawa Mizuo Maeda
Bioengineering Laboratory RIKEN
MicroRNAs (miRNAs) are short and non-protein-coding single-stranded RNAs and have shown great promise for
cancer diagnosis Some miRNAs circulate in human body fluid with extremely low concentrations and its expression
profiling can detect and classify cancers in the human body [1] Point-of-care (POC) diagnosis requires short detection
time small required sample volume and portability of the device In various miRNA detection methods microfluidic
chip meets the requirements except the portability Hence we used our power-free pump-free microfluidic chip driven
by energy that is stored in degased PDMS to overcome those drawbacks which eliminates the need for external power
sources for fluid pumping [2] The pump-free pumping method is essential for microfluidic chip-based POC diagnosis In
our laboratory rapid and sensitive singleplex miRNA detection with laminar flow-assisted dendritic amplification (LFDA)
[3] on the pump-free microfluidic chip has been developed [4] In this study rapid and sensitive multiplex miRNA
detection on the pump-free microfluidic chip was demonstrated
Pump-free microchip for multiplex miRNA detection was prepared as follows First the PDMS part with a pair of
Y-shaped microchannels with 100 μm in width and 25 μm in height was fabricated Second three parallel-line-shaped
probe DNAs were patterned onto a glass surface Third the PDMS channels were attached onto the glass plate Finally
the chip was degassed in a vacuum chamber After the chip preparation target miRNAs were detected following three
steps (1) blocking (2) sandwich hybridization of the target miRNAs and biotinylated probe DNAs and (3) signal
amplification by LFDA MiR-16 miR-21-5p and miR-500a-3p were used as target miRNAs since they are known as
cancer biomarkers [5-7] Fluorescence signals were captured by CCD camera and analyzed by the software (ImageJ)
Bright lines appeared at the expected positions they appeared only on the areas with the respective probe DNA in which
the target miRNAs had been supplied These data prove that the LFDA successfully took place in a target
sequence-dependent manner Calibration curves were plotted from the fluorescence signals The data points of the
calibration curve were fitted with the four-parameter logistic function and limit-of-detections (LODs) were evaluated by
the 3σ criterion LODs of the miR-16 miR-21-5p and miR-500a-3p were 68 fM 15 pM and 150 fM respectively The
LODs are on the same order of magnitude as concentrations of miRNA in blood Multiplex detection was verified from
correspondence between the calibration curves of single and multiplex The required sample volume was 05 microL and
assay time was 20 min Because most of the existing methods take more than a few hours the rapidness small required
sample volume and portability of the device are ideal advantages for POC diagnosis
References
[1] PS Mitchell et al PNAS 105 (2008) 10513 [2] K Hosokawa et al Lab Chip 4 (2004) 181 [3] K Hosokawa et al Anal
Chem 79 (2007) 6000 [4] H Arata et al PLoS ONE 7 (2012) e48329 [5] MJ Lodes et al PLoS ONE 4 (2009) e6229
[6] Y Toiyama et al J Natl Cancer Inst 105 (2013) 849 [7] Y Yamamoto et al Biomarkers 14 (2009) 529
19
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-5 Dr Wen-Hsuan Chiang
Assistant Researcher
Department of Biomedical Engineering and Environmental Sciences
National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
TEL (886) 3-571-5131 ext 35576
Education 2009 PhD Department of Chemical Engineering National Chung Hsing University Taiwan Thesis Supervisor Professor Hsin-Cheng Chiu 2002 BS Department of Chemical Engineering Tatung University Taiwan Professional Experience 2013 ndashpresent Assistant Researcher Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University 2010 ndash2012 Postdoctoral Fellow Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
Areas of Research Expertise Biomaterials Smart Amphiphilic Copolymers Multifunctional Nanocarriers for Cancer Therapy and Imaging Nano Science and Interfacial Engineering
Selected Publication (2010~) Wen-Hsuan Chiang Wen-Chia Huang Ming-Yin Shen Che-Hsu Wang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Dual-Layered Nanogel-Coated Hollow LipidPolypeptide Conjugate Assemblies for Potential pH-Triggered Intracellular Drug Release PLOS ONE 2014 9 1-11 Wen-Hsuan Chiang Wen-Chia Huang Chien-Wen Chang Ming-Yin Shen Zong-Fu Shih Yi-Fong Huang Sung-Chyr Lin Hsin-Cheng Chiu Functionalized Polymersomes with Outlayered Polyelectrolyte Gels for Potential Tumor-Targeted Delivery of Multimodal Therapies and MR Imaging Journal of Controlled Release 2013 168 280-288 Wen-Hsuan Chiang Viet Thang Ho Hsin-Hung Chen Wen-Chia Huang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Superparamagnetic Hollow Hybrid Nanogels as a Potential Guidable Vehicle System of Stimuli-Mediated MR Imaging and Multiple Cancer Therapeutics Langmuir 2013 29 6434-6443 Wen-Hsuan Chiang Viet Thang Ho Wen-Chia Huang Yi-Fong Huang Chorng-Shyan Chern Hsin-Cheng Chiu Dual Stimuli-Responsive Polymeric Hollow Nanogels Designed as Carriers for Intracellular Triggered Drug Release Langmuir 2012 28 15056-15064 Yi-Fong HuangDagger Wen-Hsuan ChiangDagger Pei-Ling Tsai Chorng-Shyan Chern Hsin-Cheng Chiu Novel Hybrid Vesicles Co-Assembled from Cationic Lipid and PAAc-g-mPEG with pH-Triggered Transmembrane Channels for Controlled Drug Release Chemical Communications 2011 47 10978-10980
20
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-5 Sep 13 2014 (Sat) 1140-1210 at NTHU BMES R120 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and Imaging
Applications
Wen-Hsuan Chiang
Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
In order to promote therapeutic efficacy and minimize side effect equipping these nanocarriers with the
capability of controlling drug release in response to an appropriate stimulus is essentially required Acidic pH
as an internal stimulus is particular appealing because of the mildly acid pH encountered in tumor tissues and
the intracellular compartments such as endosomes and lysosomes Therefore the pH-responsive drug carriers
have been extensively developed for improving intracellular drug delivery To realize the pH-responsive drug
release we adopted a simple approach to design the lipidPEG-containing complex vesicles with pH-triggered
transmembrane channels as a chemotherapy drug doxorubicin (DOX) delivery carrier In this study the
complex vesicles were attained by spontaneous co-assembly of poly(acrylic acid)-g-poly(monomethoxy
ethylene glycol) (PAAc-g-mPEG) with a cationic lipid didodecyldimethylammonium bromide (DDAB) in
aqueous phase of pH 89 via electrostatic interactions Through the formation of unionized AAc-rich
transmembrance channels of complex vesicles in weak acidic environments the acid-triggered rapid drug
release can be achieved
On the other hand for simultaneously monitoring disease progression and biological response after
treatments we developed a novel tumor-targeting polymersome system capable of delivering magnetic
resonance imaging (MRI) and chemotherapy The DOX-loaded magnetic polymersomes were first attained by
the self-assembly of lipid-containing copolymer poly(AAc-co-distearin acrylate) in aqueous solution
containing citric acid-coated superparamagnetic iron oxide nanoparticles (SPIONs) and followed by DOX
loading via electrostatic attraction To further functionalize these vesicles with superior in vivo colloidal
stability pH-tunable drug release and active tumor-targeting chitosan and poly( -glutamic
acid-co- -glutamyl oxysuccinimide)-g-PEG-folate (FA) were deposited in sequence onto the assembly outer
surfaces The interfacial nanogel layers via electrostatic interactions and in-situ covalent cross-linking were
thus produced Triggerable release of the encapsulated DOX was governed by dual external stimuli pH and
temperature When these theranostic NCPs were effectively internalized by HeLa cells via FA
receptor-mediated endocytosis and then exposed to high frequency magnetic fields (HFMF) the combined
effects of both pH and magnetic hyperthermia-triggered drug release and thermo-therapy resulted in greater
cytotoxicity than the treatment by DOX alone By virtue of the SPION clustering effect in the assembly inner
aqueous compartments the SPIONDOX-loaded NCPs displayed an r2 relaxivity value higher than Resovist
a commercial SPION-based T2 contrast agent The high magnetic relaxivity of the tumor-targeting NCPs
coupled with their enhanced cellular uptake considerably promoted the MRI contrast of targeted cancer cells
These results demonstrate the great potential of the FA-decorated SPIONDOX-loaded NCPs as an advanced
cancer theranostic nanodevice
21
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-1 Prof Hao-Li Liu Professor and Director
Department of Electrical Engineering
Chang Gung University
Phone +886-3-2118800 ext 5677
Fax +886-3-2118026
E-mail haoliliumailcguedutw
Education 2003 PhD National Taiwan University Taipei TAIWAN 1998 M S National Taiwan University Taipei TAIWAN 1996 B S National Taipei University of Technology TAIWAN
Professional Experience 2012-present Director Dept of Electrical Engineering Chang Gung Univ Taiwan 2011-present Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2008 Associate Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2005 ndash2008 Assistant Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2004 ndash2005 Research Fellow Department of Radiology Brigham amp Womenrsquos Hospital Harvard Medical School MA USA
Honor and awards (2009~) 2013 Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) 2013 The 2013 Frederick Lizzi Award International Society of Therapeutic Ultrasound 2011 Distinguished Tech-Coop Award (長庚大學優良教師技合獎) Chang-Gung University 2011 Wu Ta-You Memorial Award (吳大猷先生紀念獎) National Science Council Taiwan 2011 2010 Distinguished Research Award (長庚大學優良教師研究獎) Chang-Gung University
Selected Publication (2010~) HW Yang MY Hua TL Hwang KJ Lin CY Huang RY Tsai CCM Ma PH Hsu SP Wey PW Hsu PY Chen YC Huang YJ Lu TC Yen LY Feng CW Lin HL Liu KC Wei Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide Advanced Materials Vol 25 No 26 pp3605-3611 2013 HL Liu CH Fan CY Ting and CK Yeh Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors Theranostics Vol 4 No 4 pp432-444 2014 KC Wei PC Chu HYJ Wang CY Huang PY Chen HC Tsai YJ Lu IC Tseng PY Lee TC Yen and HL Liu Focused Ultrasound-induced BloodndashBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment A Preclinical Study PLoS ONE Vol 8 No 3 pp e58995 2013 P-H Hsu K-C Wei C-Y Huang C-J Wen T-C Yen C-L Liu Y-T Lin J-C Chen C-R Shen and H-L Liu Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound PLoS ONE Vol 8 No 2 pp e57682 2013 H-L Liu M-Y Hua H-W Yang C-Y Huang P-C Chu J-S Wua I-C Tseng J-J Wang T-C Yen P-Y Chen and K-C Wei ldquoMagnetic resonance monitoring of focused ultrasoundmagnetic nanoparticle targeting delivery of therapeutic agents to the brainrdquo Proceedings of National Academy of Science USA Vol 107 No 34 pp15205-15210 2010 H-L Liu M-Y Hua P-Y Chen P-C Chu C-H Pan H-W Yang C-Y Huang J-J Wang T-C Yen and K-C Wei ldquoBloodndashBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatmentrdquo Radiology Vol 255 No 2 pp 415-425 2010 H-L Liu Y-Y Wai P-H Hsu L-A Lyu J-S Wu C-R Shen J-C Chen T-C Yen and J-J Wang ldquoIn Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Bloodndashbrain Barrier with Focused Ultrasound A Magnetic Resonance Imaging Studyrdquo Journal of Cerebral Blood Flow amp Metabolism Vol 30 pp 168-177 2010
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
4
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Committee
Organizing Chair Prof Chi-Shiun Chiang Chairman BMES NTHU Taiwan
Organizing Co-Chair Prof Kohei SOGA PTRC TUS Japan
Symposium Secretariat Prof Shang-Hsiu Hu BMES NTHU Taiwan
Local Organizing Committee Prof Ruey-An Doong NTHU Taiwan
Prof Hsin-Cheng Chiu NTHU Taiwan
Prof Chih-Kuang Yeh NTHU Taiwan
Prof Yu-Fen Huang NTHU Taiwan
Dr Wen-Hsuan Chiang NTHU Taiwan
Prof Tzu-Wei Wang NTHU Taiwan
Prof Chien-Wen Chang NTHU Taiwan
Prof Yuh-Chang Sun NTHU Taiwan
Prof Fu-Nien Wang NTHU Taiwan
Prof Hsu-Hsia Peng NTHU Taiwan
Contact Prof Shang-Hsiu Hu NTHU Taiwan
Email address shhumxnthuedutw
5
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
List of Session Chairperson
Session A Biomaterials Prof Ryo Ishihara (石原量 ) (Professor Dept of Materials Science and Technology Tokyo
University of Science Japan)
Prof Hsin-Cheng Chiu (邱信程) (Professor Dept of Biomedical Engineering and Environmental
Sciences National Tsing Hua University)
Session B Biomedical Imaging Prof Chih-Kuang Yeh (葉秩光) (Professor Dept of Biomedical Engineering and Environmental
Sciences National Tsing Hua University)
Prof Kohei Soga (曽我公平) (Professor Dept of Materials Science and Technology Tokyo
University of Science Japan)
Session C Science and Technology for Environment amp Energy Prof Yu-Fen Huang (黃郁棻) (Professor Dept of Biomedical Engineering and Environmental
Sciences National Tsing Hua University)
Prof Keishi Nishio ( 西 尾 圭 史 ) (Professor Dept of Materials Science and Technology
University of Tsukuba)
6
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
List of Invited Speaker
Session A Biomaterials Prof Yung Chang (張雍) (Professor Dept of Chemical Engineering Chung Yuan University)
Prof Yutaka Ikeda (池田豊) (Professor Dept of Mater Sci University of Tsukuba Japan)
Prof Tzu-Wei Wang (王子威) (Professor Dept of Materials Science and Engineering National
Tsing Hua University)
Prof Ryo Ishihara (石原量) (Assistant Professor Dept of Materials Science and Technology
University of Tsukuba Japan)
Dr Wen-Hsuan Chiang (姜文軒) (Assistant Researcher Dept of Biomedical Engineering and
Environmental Sciences National Tsing Hua University)
Session B Biomedical Imaging Prof Hao-Li Liu (劉浩澧) (Dept of Electrical Engineering Chang Gung University Taiwan)
Dr Ichio Aoki (青木伊知男) (Molecular Imagining Center National Institute of Radiological
Sciences Japan)
Prof Meng-Lin Li (李夢麟) (Associate Professor Dept of Electrical Engineering National Tsing
Hua University)
Prof Tomoko Masaike (政池知子) (Associate Professor Tokyo University of Science Japan)
Prof Chih-Chung Huang(黃執中 ) (Assistant Professor Dept of Biomedical Engineering
National Cheng Kung University)
Prof Masao Kamimura ( 上村真生 ) (Assistant Professor Dept of Materials Science and
Technology University of Tsukuba Japan)
Session C Science and Technology for Environment amp Energy Prof Keishi Nishio (西尾圭史 ) (Professor Dept of Materials Science and Technology
University of Tsukuba)
Prof Hsing-Cheng Hsi (席行正) (Associate Professor Graduate Institute of Environmental
Engineering National Taiwan University)
Prof Kenjiro Fujimoto(藤本憲次郎 )(Department of Pure and Applied Chemistry Tokyo
University of Science)
Prof Fu-Hsiang Ko (柯富祥) (Professor Institute of Nanotechnology National Chiao Tung
University)
Prof Naoto Kitamura (北村尚斗 ) (Associate Professor Department of Pure and Applied
Chemistry Tokyo University of Science)
Prof Zong-Hong Lin (林宗宏 ) (Assistant Professor Institute of Biomedical Engineering
National Tsing Hua University)
7
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Organizer
Department of Biomedical Engineering and Environmental Sciences (BMES)
National Tsing HuaUniversity (NTHU) Taiwan
清華大學 生醫工程與環境科學系
Department of Materials Science and Technologies
Tokyo University of Science (TUS) Japan
東京理科大學 材料科學與技術系
Co-Organizer
Engineering and Technology Promotion Center
National Science Council (NSC) Taiwan
國家科學委員會 工程科技推展中心
College of Nuclear Science
National Tsing Hua Univeristy (NTHU) Taiwan
清華大學 原子科學院
8
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Map
9
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Program
September 12 (Fri) 2014
Time Agenda Speaker
1900~2100 Welcome and Opening Ceremony (Hall of Fame)
September 13 (Sat) 2014 Place NTHU BMES
Time Agenda Speaker
0830~0900 Registration (Entrance Hall NTHU BMES)
0900~0915 Opening Remarks Symposium Chairs
Session A Biomaterials Moderator Hsin-Cheng Chiu (NTHU) Ryo Ishihara (TUS)
0915~0945 Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes (Keynote)
Prof Yung Chang張
雍
0945~1015 Chemical Modifications for the Developments of Next Generation
Drugs (Keynote)
Prof Yutaka Ikeda
池田豊
1015~1045 Electrospun Composite Nanofibers with Staged Release of Multiple
Angiogenic Growth Factors for Chronic Wound Healing (Keynote)
Prof Tzu-Wei Wang
王子威
1045~1110 Break
1110~1140 Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip
toward Point-of-Care Diagnosis (invited)
Prof Ryo Ishihara石
原量
1140~1210 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and
Imaging Applications (Invited)
Dr Wen-Hsuan
Chiang姜文軒
1200~1330 Lunch
Session B Biomedical Imaging Moderator Chih-Kuang Yeh (NTHU) Kohei Soga (TUS)
1320~1400 Focused-Ultrasound Brain-Drug Delivery Approach and
Application (Keynote)
Prof Hao-Li Liu劉
浩澧
1400~1440 Responsive and Theranostic Nano-Contrast Agents for Preclinical
MR Imaging (Keynote)
Dr Ichio Aoki青木
伊知男
1440~1510 Observation of Single-Molecule Enzymes through Probes under the
Optical Microscope (Keynote)
Prof Tomoko
Masaike政池知子
1510~1630 Break
1630~1710 Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing
SPIO Nanoparticles Ultrasonically (Invited)
Prof Meng-Lin Li
李夢麟
1710~1740 High resolution ultrasound elastography for medical applications
(Invited)
Prof Chih-Chung
Huang黃執中
1740~1810 Biofunctional Polymers for Application of Ceramic Nanoparticles
for Fluorescence Bioimaging (Invited)
Prof Masao
Kamimura上村真生
1900~ Banquet (合口味)
10
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
September 14 (Sun) 2014 Place NTHU BMES
Time Agenda Speaker
0845~0900 Registration
Session C Science and Technology for Environment amp Energy
Moderator Yu-Fen Huang (NTHU) Keishi Nishio (TUS)
0900~0930 Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed
Tungsten Oxide Thin Films for Hydrogen Gas Sensor (Keynote)
Prof Keishi Nishio
西尾圭史
0930~1000 Control of low-concentration gaseous mercury from stationary
sources via adsorption and oxidation (Keynote)
Prof Hsing-Cheng
His席行正
1000~1030 High-Throughput Functional Materials Exploration by
Combinatorial WetDry Process (Keynote)
Prof Kenjiro
Fujimoto藤本憲次
郎
1030~1050 Break
1050~1120 Facile Manufacturing on Energy-efficient Devices with Flexibility
and Antireflection (Invited)
Prof Fu-Hsiang Ko
柯富祥
1120~1150 Proton Distribution and Dynamics in BaZrO3-Based Proton
Conductor for Solid Oxide Fuel Cell (Invited)
Prof Naoto
Kitamura北村尚斗
1150~1220 Harvesting Water Energy by a Sequential Contact-Electrification and
Electrostatic-Induction Process (Invited)
Prof Zong-Hong
Lin林宗宏
1210~1330 Lunch
Poster Session
1330~1530 Poster Session
1600~1800 Move to I-Lan
1800~2000 Luodong Night Market
2000 National Center for Traditional Art I-Lan (宜蘭傳藝)
September 15 (Mon) 2014 Place I-Lan
Time Agenda Speaker
0700~0800 Breakfast
0845~0910 Closing Remarks
(National Center for Traditional Art I-Lan)
0910~1500 Visit National Center for Traditional Art
1150~1330 Lunch
1530 Move to Taipei Railway Station or Hsinchu
11
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker
Invited Speaker A-1 Prof Yung Chang
Distinguished Professor
Department of Chemical Engineering
Deputy Director RampD Center for Membrane Technology
Chung Yuan Christian University
Address Jhong-Li Taoyuan 320 Taiwan
TEL (886) 265-4122
FAX (886) 265-4190
Education 2004 PhD Chemical Engineering National Taiwan University Taiwan 2000 MS Chemical Engineering National Taiwan University Taiwan 1998 BS Chemical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013-present Deputy Director RampD Center for Membrane Technology Chung Yuan Christian
University 2013-present Distinguished Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2013-present Professor Department of Chemical Engineering Chung Yuan Christian University
Taiwan 2009-2013 Associate Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2006-2009 Assistant Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2005-2006 Postdoctoral Fellow Chemical Engineering University of Washington USA 2004-2005 Postdoctoral Fellow Chemical Engineering National Taiwan University Taiwan
Honor and awards (2010~) 2010 Yung Investigator Award of Chemical Engineering (Taiwan Institute of Chemical Engineers) 2010 Yung Investigator Award of Materials on Regenerative Medicine (National Health Research
Institutes Taiwan) 2011 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan) 2011 Outstanding Research Award of Chemical Engineering (LCY Chemical Corp) 2012 NSC Wu Da-Yu Award (National science council Taiwan) 2012 NSC Outstanding AcademicIndustrial Cooperation Award (National science council) 2013 Yung Investigator Award of Polymer Science (Taiwan Institute of Polymer Science) 2013 JCS The Distinguished Lectureship Award Biomaterial Research (Japan Chemical Society) 2013 Ukraine International Invention Exhibition Gold Medal (Ukraine Invention Society) 2014 Pittsburgh International Invention Exhibition Gold Medal (USA Invention Society) 2014 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan)
12
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-1 Sep 13 2014 (Sat) 0915-0945 at NTHU BMES R120
Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes
Chung Yuan
RampD Center for Membrane Technology and Department of Chemical Engineering Christian
University Chung-Li Taoyuan 320 Taiwan
Zwitterionic polymeric interface resisting the adsorption of plasma proteins is important in the
development of blood-contacting biomaterials in such applications as blood collection devices
antithrombogenic implants hemodialysis membranes drug-delivery carriers and diagnostic
biosensors Previous studies showed that the control of surface charge neutrality is important for a
zwitterionic surface with effective protein-resistant properties Importantly it was further reported
that the mixed-charge formulation in self-assembled monolayers copolymer hydrogels and
polymeric brushes provide a new avenue to achieve nonfouling surfaces with the prevention of
nonspecific protein adsorption if the charge balance can be well controlled This talk will cover three
major studies
Bio-inert nature of biomimetic zwitterionicpseudozwitterionic structures
Blood-Inert
Surfaces via ion-pair anchoring of zwitterionic copolymer brushes in human whole blood Surface
zwitterionization of membrenaes in novel biomedical applications
[1] Chang Y Liao SC Higuchi A Ruaan RC Chu CW Chen WY A highly stable nonbiofouling surface with
well-packed grafted zwitterionic polysulfobetaine for plasma protein repulsion Langmuir 2008245453-58
[2] Chiag YC Chang Y Higuchi A Chen WY Ruaan RC Sulfobetaine-grafted poly(vinylidene fluroride) ultrafiltration
membranes exhibit excellent antifouling property Journal of Membrane Science 2009339151-9
[3] Chang Y Yandi W Chen WY Shih YJ Yang CC Chang Y Ling QD Higuchi A Tunable bioadhesive copolymer
hydrogels of thermoresponsive poly(N-isopropyl acrylamide) containing zwitterionic polysulfobetaine
Biomacromolecules 2010111101-10
[4] Chang Y Chang WJ Shih YJ Wei TC Hsiue GH Zwitterionic sulfobetaine-grafted poly(vinylidene fluoride)
membrane with improved blood compatibility via atmospheric plasma-induced surface copolymerization ACS Appl
Mater Interfaces 201131228-37
[5] Shih YJ Chang Y Deratani A Damien Q Schizophrenic hemocompatible copolymers via switchable
thermoresponsive transition of nonioniczwitterionic block self-assembly in human blood Biomacromolecules
2012132849minus58
[6] Chang Y Shih YJ Lai CJ Kung HH Jiang S Ion-pair anchoring of self-assembled zwitterionic copolymer surfaces
with highly controlled blood compatibility Advanced Functional Materials 2013231100-10
13
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-2 Dr Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences
University of Tsukuba
Address Tennoudai 1-1-1 Tsukuba Ibaraki 305-8573 Japan
E-mailikedaimstsukubaacjp
Education March 1999 B S in Faculty of Engineering Kyoto University March 2001 MS in Graduate School of Engineering Department of Synthetic Chemistry and
Biological Chemistry Kyoto University March 2004 PhD in School of Engineering The University of Tokyo
Professional Experience 2004~2006 Advanced industrial science and technology (AIST) 2006~2008 Cytopathfinder Inc 2008~to date University of Tsukuba
Selected Publication (2010~) Y Ikeda J Katamachi H Kawasaki Y Nagasaki Novel protein PEGylation chemistry via glutalaldehydefunctionalized PEG Bioconjugate Chemistry 24 1824-1827 (2013) Y Ikeda D Kubota Y Nagasaki Design of sugar-oligonucleotide conjugates installed gold nanoparticle for effective delivery to hepatic parenchymal cells Colloid and Polymer Science 291 2959-2964 Y Ikeda H Kawasaki S Ichinohe Y Nagasaki Facile solid-phase synthesis of a highly stable poly(ethylene glycol)-oligonucleotide conjugate Journal of Materials Chemistry B 1 529-535(2013) Y Ikeda T Jomura U Horiuchi J Saeki K Yoshimoto T Ikeya Y Nagasaki Long-term survival and functional maintenance of hepatocytes by using a microfabricated cell array Colloid and Surface B Biointerface 97 97-100 2012 Y Ikeda Y Nagasaki PEGylation Technology in Nanomedicine Advances in Polymer Science 247 115-140 2012 Y Ikeda R Suzuki T Yoshitomi Y Nagasaki Novel oligonucleotide carrier possessing reactive oxygen species scavenging ability Macromolecular Bioscience 2011 11 344-351 Y Ikeda D Kubota Y Nagasaki Simple solid-phase synthesis and biological properties of carbohydrate-oligonucleotide conjugates modified at the 3rsquo terminus Bioconjugate Chem 2010 21 1685-1690
14
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-2 Sep 13 2014 (Sat) 0945-1015 at NTHU BMES R120
Chemical Modifications for the Developments of Next Generation Drugs
Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences University of
Tsukuba
Controlling of biodistribution and PKPD is a key issue for the development of drugsVariety of
technologies have been reported to improve those properties Those technologies include
nanoparticle formulation and PEGylation technology In my presentation I will show recent
chemical modification technologies which we developed to improve PKPD and distribution of
drugs
A novel chemistry for the PEGylated protein with a high activity
Several PEGylated proteins have been approved as therapeutic drugs In many cases PEGylated
protein has been synthesized by the conjugation reaction between PEG possessing activated ester and
amine(s) in the protein This reaction however often causes inactivation of PEGylated proteins In
this report we present a novel chemistry which enables the PEGylation of proteins under the mild
reaction condition PEGylated lysozyme prepared by the method developed increased the biological
activity of the PEGylated lysozyme more than 20 times compared with the PEGylated lysozyme
prepared by the conventional method
Design and development of novel hypoxically activated prodrugs
Tumor hypoxia is well known to promote mutagenesis invasiveness and to be associated with a
worse prognosis Although the treatment of the tumor hypoxia has been highly demanded resistance
to radiotherapy and anticancer chemotherapy have been serious problems The object of this study
was the development of hypoxically activated prodrugs which accumulate and act on cells at hypoxic
region of tumor Several conventional anti-cancer drugs including doxorubicin gemcitabine and 5FU
have been modified with 2-nitro imidazole derivative This modification enabled inactivation of drug
to reduce adverse effects under the normoxia condition and selective activation of prodrug under the
hypoxic condition
15
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-3 Prof Tzu-Wei Wang
Associate Professor
Department of Materials Science and Engineering and Institute of Biomedical
Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013
Office Delta Teaching Building R434
TEL +886-3-5715131 ext 33856
Email twwangmxnthuedutw Education 2006 PhD Institute of Biomedical Engineering National Taiwan University Taiwan
Professional Experience 2013 ndashpresent Associate Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2009 -2013 Assistant Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2007-2009 Postdoctoral Research Fellow Tissue Engineering Laboratories of Brigham and Womenrsquos
Hospital Harvard Medical School USA
Honor and awards (2009~) Young Plenary Award 2013 TERMIS-AP Symposium Shanghai China (2013) The 9th National Innovation Award Academic Research Category by Institute for Biotechnology and Medicine Industry Taiwan (2012) Young Investigator Award International Symposium of Materials on Regenerative Medicine Taiwan (2012 ISOMRM) Young Investigator Award 5th World Congress on Bioengineering the World Association for Chinese Biomedical Engineers Taiwan (WACBE 2011)
Selected Publication (2012~) Yang CS Wu HC Sun JS Hsiao HM Wang TW Thermo-induced shape memory PEG-PCL copolymer as dual drug-eluting biodegradable stent ACS Appl Mater Interfaces 2013 5 (21) 10985ndash10994 Yeh PH Sun JS Wu HC Hwang LH Wang TW Stimuli-responsive HA-PEI nanoparticles encapsulating endostatin plasmid for stem cell gene therapy RSC Advances 2013 3 (31) 12922 - 12932 Chen YY Wu HC Sun JS Dong GC Wang TW Injectable and thermoresponsive self-assembled nanocomposite hydrogel for long-term anticancer drug delivery Langmuir 201329(11)3721-3729 Cheng TY Wu HC Chang WH Huang MY Lee CH Wang TW Self-assembling functionalized nanopeptides for immediate hemostasis and accelerative liver tissue regeneration Nanoscale 2013 5 (7) 2734 - 2744 Chang YJ Tsai CJ Tseng FG Chen TJ Wang TW Micropatterned Stretching System for the Investigation of Mechanical Tension on Neural Stem Cells Behavior Nanomedicine Nanotechnology Biology and Medicine 20139345-355 Cheng TY Chen MH Chang WH Huang MY Wang TW Neural stem cells encapsulated in a functionalized self-assembling peptide hydrogel for brain tissue engineering Biomaterials 2013 34(8)2005-2016 Goh JH Wu HC Chen MH Chen MY Chang SC Wang TW Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages Acta Biomaterialia 20139(2)5170-5180 Huang YJ Wu HC Tai NH Wang TW Carbon Nanotube Rope with Electrical Stimulation Promotes the Differentiation and Maturity of Neural Stem Cells Small 20128(18) 2869ndash2877
16
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-3 Sep 13 2014 (Sat) 1015-1045 at NTHU BMES R120
Electrospun Composite Nanofibers with Staged Release of Multiple Angiogenic Growth Factors for Chronic Wound Healing
Tzu-Wei Wang
Department of Materials Science and Engineering and Institute of Biomedical Engineering National
Tsing Hua University
The objective of this research study is to develop collagen (Col) and hyaluronic acid (HA)
inter-stacking nanofibrous skin equivalent substitute with programmable release of multiple
angiogenic growth factors (VEGF PDGF bFGF and EGF) either directly embedded in the
nanofibers or encapsulated in the gelatin nanoparticles (GN) by electrospinning technology The
delivery of EGF and bFGF in early stage is expected to accelerate epithelialization and vasculature
sprouting while release of PDGF and VEGF in late stage is aimed for the induction of blood vessels
maturation The physiochemical characterizations report that the Col-HA-GN nanofibrous membrane
possesses mechanical property similar to human native skin The design of particle-in-fiber structure
allows growth factors for slow controlled release up to one month Cultured on biodegradable
Col-HA membrane with four kinds of growth factors (Col-HA w4GF) endothelial cells not only
increase in growth rate but also form better network of thread-like tubular structure Therapeutic
effect of Col-HA w4GF membrane on STZ-induced diabetic rats reveal accelerated wound closure
rate elevated collagen deposition and enhanced mature vessels by Massonrsquos trichrome stain and
immunohistochemical analysis respectively From the above the electrospun Col-HA-GN composite
nanofibrous skin substitute with stage-wise release pattern of multiple angiogenic factors could be a
promising bioengineered construct for the chronic wound healing in skin tissue regeneration
17
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-4 Assistant Prof Ryo Ishihara
Assistant Professor
Department of Materials Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
Tokyo University of Science Research Building 9th floor
TEL +81-3-5876-1415
FAX +81-3-5876-1415
Education 2012 PhD Department of Applied Chemistry and Biotechnology Chiba University Japan 2008 MS Department of Materials Technology Chiba University Japan 2006 BS Department of Materials Technology Chiba University Japan
Professional Experience 2014 ndashpresent Assistant Professor Department of Materials Science and Technology Tokyo
University of Science 2012 ndash2014 Postdoctral Researcher Bioengineering Laboratory RIKEN
Honor and awards Department chairmanlsquos award from Chiba University (2012)
Selected Publication (2010~) Simple Method for High-Density Impregnation of Aliquat 336 onto Porous Sheet and Binding Performance of Resulting Sheet for Palladium Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota Sep Sci Technol 49154-159 (2014) Effect of Dose on Mole Percentage of Polymer Brush and Root Grafted onto Porous Polyethylene Sheet by Radiation-Induced Graft Polymerization R Ishihara S Uchiyama H Ikezawa S Yamada H Hirota D Umeno K Saito Ind Eng Chem Res 5212582-12586 (2013) Determination of Mole Percentages of Brush and Root of Polymer Chain Grafted onto Porous Sheet S Uchiyama R Ishihara D Umeno K Saito S Yamada H Hirota S Asai J Chem Eng Japan 46414-419 (2013) Crosslinked-chelating Porous Sheet with High Dynamic Binding Capacity of Metal Ions G Wada R Ishihara K Miyoshi D Umeno K Saito S Yamada H Hirota Solv Extr Ion Exch 31210-220 (2013) Dependence of Lanthanide-Ion Binding Performance on HDEHP Concentration in HDEHP Impregnation to Porous Sheet R Ishihara S Asai S Otosaka S Yamada H Hirota K Miyoshi D Umeno K Saito Solv Extr Ion Exch 30171-180 (2012) Impregnation of TOPO onto Hydrophobic-Ligand-Containing Porous Sheet and Its Adsorptionelution Performance of Bismuth Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota React Funct Polym 70986-990 (2010)
18
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-4 Sep 13 2014 (Sat) 1110-1140 at NTHU BMES R120
Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip toward Point-of-Care Diagnosis
Ryo Ishihara Kazuo Hosokawa Mizuo Maeda
Bioengineering Laboratory RIKEN
MicroRNAs (miRNAs) are short and non-protein-coding single-stranded RNAs and have shown great promise for
cancer diagnosis Some miRNAs circulate in human body fluid with extremely low concentrations and its expression
profiling can detect and classify cancers in the human body [1] Point-of-care (POC) diagnosis requires short detection
time small required sample volume and portability of the device In various miRNA detection methods microfluidic
chip meets the requirements except the portability Hence we used our power-free pump-free microfluidic chip driven
by energy that is stored in degased PDMS to overcome those drawbacks which eliminates the need for external power
sources for fluid pumping [2] The pump-free pumping method is essential for microfluidic chip-based POC diagnosis In
our laboratory rapid and sensitive singleplex miRNA detection with laminar flow-assisted dendritic amplification (LFDA)
[3] on the pump-free microfluidic chip has been developed [4] In this study rapid and sensitive multiplex miRNA
detection on the pump-free microfluidic chip was demonstrated
Pump-free microchip for multiplex miRNA detection was prepared as follows First the PDMS part with a pair of
Y-shaped microchannels with 100 μm in width and 25 μm in height was fabricated Second three parallel-line-shaped
probe DNAs were patterned onto a glass surface Third the PDMS channels were attached onto the glass plate Finally
the chip was degassed in a vacuum chamber After the chip preparation target miRNAs were detected following three
steps (1) blocking (2) sandwich hybridization of the target miRNAs and biotinylated probe DNAs and (3) signal
amplification by LFDA MiR-16 miR-21-5p and miR-500a-3p were used as target miRNAs since they are known as
cancer biomarkers [5-7] Fluorescence signals were captured by CCD camera and analyzed by the software (ImageJ)
Bright lines appeared at the expected positions they appeared only on the areas with the respective probe DNA in which
the target miRNAs had been supplied These data prove that the LFDA successfully took place in a target
sequence-dependent manner Calibration curves were plotted from the fluorescence signals The data points of the
calibration curve were fitted with the four-parameter logistic function and limit-of-detections (LODs) were evaluated by
the 3σ criterion LODs of the miR-16 miR-21-5p and miR-500a-3p were 68 fM 15 pM and 150 fM respectively The
LODs are on the same order of magnitude as concentrations of miRNA in blood Multiplex detection was verified from
correspondence between the calibration curves of single and multiplex The required sample volume was 05 microL and
assay time was 20 min Because most of the existing methods take more than a few hours the rapidness small required
sample volume and portability of the device are ideal advantages for POC diagnosis
References
[1] PS Mitchell et al PNAS 105 (2008) 10513 [2] K Hosokawa et al Lab Chip 4 (2004) 181 [3] K Hosokawa et al Anal
Chem 79 (2007) 6000 [4] H Arata et al PLoS ONE 7 (2012) e48329 [5] MJ Lodes et al PLoS ONE 4 (2009) e6229
[6] Y Toiyama et al J Natl Cancer Inst 105 (2013) 849 [7] Y Yamamoto et al Biomarkers 14 (2009) 529
19
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-5 Dr Wen-Hsuan Chiang
Assistant Researcher
Department of Biomedical Engineering and Environmental Sciences
National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
TEL (886) 3-571-5131 ext 35576
Education 2009 PhD Department of Chemical Engineering National Chung Hsing University Taiwan Thesis Supervisor Professor Hsin-Cheng Chiu 2002 BS Department of Chemical Engineering Tatung University Taiwan Professional Experience 2013 ndashpresent Assistant Researcher Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University 2010 ndash2012 Postdoctoral Fellow Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
Areas of Research Expertise Biomaterials Smart Amphiphilic Copolymers Multifunctional Nanocarriers for Cancer Therapy and Imaging Nano Science and Interfacial Engineering
Selected Publication (2010~) Wen-Hsuan Chiang Wen-Chia Huang Ming-Yin Shen Che-Hsu Wang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Dual-Layered Nanogel-Coated Hollow LipidPolypeptide Conjugate Assemblies for Potential pH-Triggered Intracellular Drug Release PLOS ONE 2014 9 1-11 Wen-Hsuan Chiang Wen-Chia Huang Chien-Wen Chang Ming-Yin Shen Zong-Fu Shih Yi-Fong Huang Sung-Chyr Lin Hsin-Cheng Chiu Functionalized Polymersomes with Outlayered Polyelectrolyte Gels for Potential Tumor-Targeted Delivery of Multimodal Therapies and MR Imaging Journal of Controlled Release 2013 168 280-288 Wen-Hsuan Chiang Viet Thang Ho Hsin-Hung Chen Wen-Chia Huang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Superparamagnetic Hollow Hybrid Nanogels as a Potential Guidable Vehicle System of Stimuli-Mediated MR Imaging and Multiple Cancer Therapeutics Langmuir 2013 29 6434-6443 Wen-Hsuan Chiang Viet Thang Ho Wen-Chia Huang Yi-Fong Huang Chorng-Shyan Chern Hsin-Cheng Chiu Dual Stimuli-Responsive Polymeric Hollow Nanogels Designed as Carriers for Intracellular Triggered Drug Release Langmuir 2012 28 15056-15064 Yi-Fong HuangDagger Wen-Hsuan ChiangDagger Pei-Ling Tsai Chorng-Shyan Chern Hsin-Cheng Chiu Novel Hybrid Vesicles Co-Assembled from Cationic Lipid and PAAc-g-mPEG with pH-Triggered Transmembrane Channels for Controlled Drug Release Chemical Communications 2011 47 10978-10980
20
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-5 Sep 13 2014 (Sat) 1140-1210 at NTHU BMES R120 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and Imaging
Applications
Wen-Hsuan Chiang
Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
In order to promote therapeutic efficacy and minimize side effect equipping these nanocarriers with the
capability of controlling drug release in response to an appropriate stimulus is essentially required Acidic pH
as an internal stimulus is particular appealing because of the mildly acid pH encountered in tumor tissues and
the intracellular compartments such as endosomes and lysosomes Therefore the pH-responsive drug carriers
have been extensively developed for improving intracellular drug delivery To realize the pH-responsive drug
release we adopted a simple approach to design the lipidPEG-containing complex vesicles with pH-triggered
transmembrane channels as a chemotherapy drug doxorubicin (DOX) delivery carrier In this study the
complex vesicles were attained by spontaneous co-assembly of poly(acrylic acid)-g-poly(monomethoxy
ethylene glycol) (PAAc-g-mPEG) with a cationic lipid didodecyldimethylammonium bromide (DDAB) in
aqueous phase of pH 89 via electrostatic interactions Through the formation of unionized AAc-rich
transmembrance channels of complex vesicles in weak acidic environments the acid-triggered rapid drug
release can be achieved
On the other hand for simultaneously monitoring disease progression and biological response after
treatments we developed a novel tumor-targeting polymersome system capable of delivering magnetic
resonance imaging (MRI) and chemotherapy The DOX-loaded magnetic polymersomes were first attained by
the self-assembly of lipid-containing copolymer poly(AAc-co-distearin acrylate) in aqueous solution
containing citric acid-coated superparamagnetic iron oxide nanoparticles (SPIONs) and followed by DOX
loading via electrostatic attraction To further functionalize these vesicles with superior in vivo colloidal
stability pH-tunable drug release and active tumor-targeting chitosan and poly( -glutamic
acid-co- -glutamyl oxysuccinimide)-g-PEG-folate (FA) were deposited in sequence onto the assembly outer
surfaces The interfacial nanogel layers via electrostatic interactions and in-situ covalent cross-linking were
thus produced Triggerable release of the encapsulated DOX was governed by dual external stimuli pH and
temperature When these theranostic NCPs were effectively internalized by HeLa cells via FA
receptor-mediated endocytosis and then exposed to high frequency magnetic fields (HFMF) the combined
effects of both pH and magnetic hyperthermia-triggered drug release and thermo-therapy resulted in greater
cytotoxicity than the treatment by DOX alone By virtue of the SPION clustering effect in the assembly inner
aqueous compartments the SPIONDOX-loaded NCPs displayed an r2 relaxivity value higher than Resovist
a commercial SPION-based T2 contrast agent The high magnetic relaxivity of the tumor-targeting NCPs
coupled with their enhanced cellular uptake considerably promoted the MRI contrast of targeted cancer cells
These results demonstrate the great potential of the FA-decorated SPIONDOX-loaded NCPs as an advanced
cancer theranostic nanodevice
21
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-1 Prof Hao-Li Liu Professor and Director
Department of Electrical Engineering
Chang Gung University
Phone +886-3-2118800 ext 5677
Fax +886-3-2118026
E-mail haoliliumailcguedutw
Education 2003 PhD National Taiwan University Taipei TAIWAN 1998 M S National Taiwan University Taipei TAIWAN 1996 B S National Taipei University of Technology TAIWAN
Professional Experience 2012-present Director Dept of Electrical Engineering Chang Gung Univ Taiwan 2011-present Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2008 Associate Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2005 ndash2008 Assistant Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2004 ndash2005 Research Fellow Department of Radiology Brigham amp Womenrsquos Hospital Harvard Medical School MA USA
Honor and awards (2009~) 2013 Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) 2013 The 2013 Frederick Lizzi Award International Society of Therapeutic Ultrasound 2011 Distinguished Tech-Coop Award (長庚大學優良教師技合獎) Chang-Gung University 2011 Wu Ta-You Memorial Award (吳大猷先生紀念獎) National Science Council Taiwan 2011 2010 Distinguished Research Award (長庚大學優良教師研究獎) Chang-Gung University
Selected Publication (2010~) HW Yang MY Hua TL Hwang KJ Lin CY Huang RY Tsai CCM Ma PH Hsu SP Wey PW Hsu PY Chen YC Huang YJ Lu TC Yen LY Feng CW Lin HL Liu KC Wei Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide Advanced Materials Vol 25 No 26 pp3605-3611 2013 HL Liu CH Fan CY Ting and CK Yeh Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors Theranostics Vol 4 No 4 pp432-444 2014 KC Wei PC Chu HYJ Wang CY Huang PY Chen HC Tsai YJ Lu IC Tseng PY Lee TC Yen and HL Liu Focused Ultrasound-induced BloodndashBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment A Preclinical Study PLoS ONE Vol 8 No 3 pp e58995 2013 P-H Hsu K-C Wei C-Y Huang C-J Wen T-C Yen C-L Liu Y-T Lin J-C Chen C-R Shen and H-L Liu Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound PLoS ONE Vol 8 No 2 pp e57682 2013 H-L Liu M-Y Hua H-W Yang C-Y Huang P-C Chu J-S Wua I-C Tseng J-J Wang T-C Yen P-Y Chen and K-C Wei ldquoMagnetic resonance monitoring of focused ultrasoundmagnetic nanoparticle targeting delivery of therapeutic agents to the brainrdquo Proceedings of National Academy of Science USA Vol 107 No 34 pp15205-15210 2010 H-L Liu M-Y Hua P-Y Chen P-C Chu C-H Pan H-W Yang C-Y Huang J-J Wang T-C Yen and K-C Wei ldquoBloodndashBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatmentrdquo Radiology Vol 255 No 2 pp 415-425 2010 H-L Liu Y-Y Wai P-H Hsu L-A Lyu J-S Wu C-R Shen J-C Chen T-C Yen and J-J Wang ldquoIn Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Bloodndashbrain Barrier with Focused Ultrasound A Magnetic Resonance Imaging Studyrdquo Journal of Cerebral Blood Flow amp Metabolism Vol 30 pp 168-177 2010
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
5
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
List of Session Chairperson
Session A Biomaterials Prof Ryo Ishihara (石原量 ) (Professor Dept of Materials Science and Technology Tokyo
University of Science Japan)
Prof Hsin-Cheng Chiu (邱信程) (Professor Dept of Biomedical Engineering and Environmental
Sciences National Tsing Hua University)
Session B Biomedical Imaging Prof Chih-Kuang Yeh (葉秩光) (Professor Dept of Biomedical Engineering and Environmental
Sciences National Tsing Hua University)
Prof Kohei Soga (曽我公平) (Professor Dept of Materials Science and Technology Tokyo
University of Science Japan)
Session C Science and Technology for Environment amp Energy Prof Yu-Fen Huang (黃郁棻) (Professor Dept of Biomedical Engineering and Environmental
Sciences National Tsing Hua University)
Prof Keishi Nishio ( 西 尾 圭 史 ) (Professor Dept of Materials Science and Technology
University of Tsukuba)
6
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
List of Invited Speaker
Session A Biomaterials Prof Yung Chang (張雍) (Professor Dept of Chemical Engineering Chung Yuan University)
Prof Yutaka Ikeda (池田豊) (Professor Dept of Mater Sci University of Tsukuba Japan)
Prof Tzu-Wei Wang (王子威) (Professor Dept of Materials Science and Engineering National
Tsing Hua University)
Prof Ryo Ishihara (石原量) (Assistant Professor Dept of Materials Science and Technology
University of Tsukuba Japan)
Dr Wen-Hsuan Chiang (姜文軒) (Assistant Researcher Dept of Biomedical Engineering and
Environmental Sciences National Tsing Hua University)
Session B Biomedical Imaging Prof Hao-Li Liu (劉浩澧) (Dept of Electrical Engineering Chang Gung University Taiwan)
Dr Ichio Aoki (青木伊知男) (Molecular Imagining Center National Institute of Radiological
Sciences Japan)
Prof Meng-Lin Li (李夢麟) (Associate Professor Dept of Electrical Engineering National Tsing
Hua University)
Prof Tomoko Masaike (政池知子) (Associate Professor Tokyo University of Science Japan)
Prof Chih-Chung Huang(黃執中 ) (Assistant Professor Dept of Biomedical Engineering
National Cheng Kung University)
Prof Masao Kamimura ( 上村真生 ) (Assistant Professor Dept of Materials Science and
Technology University of Tsukuba Japan)
Session C Science and Technology for Environment amp Energy Prof Keishi Nishio (西尾圭史 ) (Professor Dept of Materials Science and Technology
University of Tsukuba)
Prof Hsing-Cheng Hsi (席行正) (Associate Professor Graduate Institute of Environmental
Engineering National Taiwan University)
Prof Kenjiro Fujimoto(藤本憲次郎 )(Department of Pure and Applied Chemistry Tokyo
University of Science)
Prof Fu-Hsiang Ko (柯富祥) (Professor Institute of Nanotechnology National Chiao Tung
University)
Prof Naoto Kitamura (北村尚斗 ) (Associate Professor Department of Pure and Applied
Chemistry Tokyo University of Science)
Prof Zong-Hong Lin (林宗宏 ) (Assistant Professor Institute of Biomedical Engineering
National Tsing Hua University)
7
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Organizer
Department of Biomedical Engineering and Environmental Sciences (BMES)
National Tsing HuaUniversity (NTHU) Taiwan
清華大學 生醫工程與環境科學系
Department of Materials Science and Technologies
Tokyo University of Science (TUS) Japan
東京理科大學 材料科學與技術系
Co-Organizer
Engineering and Technology Promotion Center
National Science Council (NSC) Taiwan
國家科學委員會 工程科技推展中心
College of Nuclear Science
National Tsing Hua Univeristy (NTHU) Taiwan
清華大學 原子科學院
8
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Map
9
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Program
September 12 (Fri) 2014
Time Agenda Speaker
1900~2100 Welcome and Opening Ceremony (Hall of Fame)
September 13 (Sat) 2014 Place NTHU BMES
Time Agenda Speaker
0830~0900 Registration (Entrance Hall NTHU BMES)
0900~0915 Opening Remarks Symposium Chairs
Session A Biomaterials Moderator Hsin-Cheng Chiu (NTHU) Ryo Ishihara (TUS)
0915~0945 Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes (Keynote)
Prof Yung Chang張
雍
0945~1015 Chemical Modifications for the Developments of Next Generation
Drugs (Keynote)
Prof Yutaka Ikeda
池田豊
1015~1045 Electrospun Composite Nanofibers with Staged Release of Multiple
Angiogenic Growth Factors for Chronic Wound Healing (Keynote)
Prof Tzu-Wei Wang
王子威
1045~1110 Break
1110~1140 Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip
toward Point-of-Care Diagnosis (invited)
Prof Ryo Ishihara石
原量
1140~1210 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and
Imaging Applications (Invited)
Dr Wen-Hsuan
Chiang姜文軒
1200~1330 Lunch
Session B Biomedical Imaging Moderator Chih-Kuang Yeh (NTHU) Kohei Soga (TUS)
1320~1400 Focused-Ultrasound Brain-Drug Delivery Approach and
Application (Keynote)
Prof Hao-Li Liu劉
浩澧
1400~1440 Responsive and Theranostic Nano-Contrast Agents for Preclinical
MR Imaging (Keynote)
Dr Ichio Aoki青木
伊知男
1440~1510 Observation of Single-Molecule Enzymes through Probes under the
Optical Microscope (Keynote)
Prof Tomoko
Masaike政池知子
1510~1630 Break
1630~1710 Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing
SPIO Nanoparticles Ultrasonically (Invited)
Prof Meng-Lin Li
李夢麟
1710~1740 High resolution ultrasound elastography for medical applications
(Invited)
Prof Chih-Chung
Huang黃執中
1740~1810 Biofunctional Polymers for Application of Ceramic Nanoparticles
for Fluorescence Bioimaging (Invited)
Prof Masao
Kamimura上村真生
1900~ Banquet (合口味)
10
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
September 14 (Sun) 2014 Place NTHU BMES
Time Agenda Speaker
0845~0900 Registration
Session C Science and Technology for Environment amp Energy
Moderator Yu-Fen Huang (NTHU) Keishi Nishio (TUS)
0900~0930 Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed
Tungsten Oxide Thin Films for Hydrogen Gas Sensor (Keynote)
Prof Keishi Nishio
西尾圭史
0930~1000 Control of low-concentration gaseous mercury from stationary
sources via adsorption and oxidation (Keynote)
Prof Hsing-Cheng
His席行正
1000~1030 High-Throughput Functional Materials Exploration by
Combinatorial WetDry Process (Keynote)
Prof Kenjiro
Fujimoto藤本憲次
郎
1030~1050 Break
1050~1120 Facile Manufacturing on Energy-efficient Devices with Flexibility
and Antireflection (Invited)
Prof Fu-Hsiang Ko
柯富祥
1120~1150 Proton Distribution and Dynamics in BaZrO3-Based Proton
Conductor for Solid Oxide Fuel Cell (Invited)
Prof Naoto
Kitamura北村尚斗
1150~1220 Harvesting Water Energy by a Sequential Contact-Electrification and
Electrostatic-Induction Process (Invited)
Prof Zong-Hong
Lin林宗宏
1210~1330 Lunch
Poster Session
1330~1530 Poster Session
1600~1800 Move to I-Lan
1800~2000 Luodong Night Market
2000 National Center for Traditional Art I-Lan (宜蘭傳藝)
September 15 (Mon) 2014 Place I-Lan
Time Agenda Speaker
0700~0800 Breakfast
0845~0910 Closing Remarks
(National Center for Traditional Art I-Lan)
0910~1500 Visit National Center for Traditional Art
1150~1330 Lunch
1530 Move to Taipei Railway Station or Hsinchu
11
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker
Invited Speaker A-1 Prof Yung Chang
Distinguished Professor
Department of Chemical Engineering
Deputy Director RampD Center for Membrane Technology
Chung Yuan Christian University
Address Jhong-Li Taoyuan 320 Taiwan
TEL (886) 265-4122
FAX (886) 265-4190
Education 2004 PhD Chemical Engineering National Taiwan University Taiwan 2000 MS Chemical Engineering National Taiwan University Taiwan 1998 BS Chemical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013-present Deputy Director RampD Center for Membrane Technology Chung Yuan Christian
University 2013-present Distinguished Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2013-present Professor Department of Chemical Engineering Chung Yuan Christian University
Taiwan 2009-2013 Associate Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2006-2009 Assistant Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2005-2006 Postdoctoral Fellow Chemical Engineering University of Washington USA 2004-2005 Postdoctoral Fellow Chemical Engineering National Taiwan University Taiwan
Honor and awards (2010~) 2010 Yung Investigator Award of Chemical Engineering (Taiwan Institute of Chemical Engineers) 2010 Yung Investigator Award of Materials on Regenerative Medicine (National Health Research
Institutes Taiwan) 2011 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan) 2011 Outstanding Research Award of Chemical Engineering (LCY Chemical Corp) 2012 NSC Wu Da-Yu Award (National science council Taiwan) 2012 NSC Outstanding AcademicIndustrial Cooperation Award (National science council) 2013 Yung Investigator Award of Polymer Science (Taiwan Institute of Polymer Science) 2013 JCS The Distinguished Lectureship Award Biomaterial Research (Japan Chemical Society) 2013 Ukraine International Invention Exhibition Gold Medal (Ukraine Invention Society) 2014 Pittsburgh International Invention Exhibition Gold Medal (USA Invention Society) 2014 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan)
12
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-1 Sep 13 2014 (Sat) 0915-0945 at NTHU BMES R120
Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes
Chung Yuan
RampD Center for Membrane Technology and Department of Chemical Engineering Christian
University Chung-Li Taoyuan 320 Taiwan
Zwitterionic polymeric interface resisting the adsorption of plasma proteins is important in the
development of blood-contacting biomaterials in such applications as blood collection devices
antithrombogenic implants hemodialysis membranes drug-delivery carriers and diagnostic
biosensors Previous studies showed that the control of surface charge neutrality is important for a
zwitterionic surface with effective protein-resistant properties Importantly it was further reported
that the mixed-charge formulation in self-assembled monolayers copolymer hydrogels and
polymeric brushes provide a new avenue to achieve nonfouling surfaces with the prevention of
nonspecific protein adsorption if the charge balance can be well controlled This talk will cover three
major studies
Bio-inert nature of biomimetic zwitterionicpseudozwitterionic structures
Blood-Inert
Surfaces via ion-pair anchoring of zwitterionic copolymer brushes in human whole blood Surface
zwitterionization of membrenaes in novel biomedical applications
[1] Chang Y Liao SC Higuchi A Ruaan RC Chu CW Chen WY A highly stable nonbiofouling surface with
well-packed grafted zwitterionic polysulfobetaine for plasma protein repulsion Langmuir 2008245453-58
[2] Chiag YC Chang Y Higuchi A Chen WY Ruaan RC Sulfobetaine-grafted poly(vinylidene fluroride) ultrafiltration
membranes exhibit excellent antifouling property Journal of Membrane Science 2009339151-9
[3] Chang Y Yandi W Chen WY Shih YJ Yang CC Chang Y Ling QD Higuchi A Tunable bioadhesive copolymer
hydrogels of thermoresponsive poly(N-isopropyl acrylamide) containing zwitterionic polysulfobetaine
Biomacromolecules 2010111101-10
[4] Chang Y Chang WJ Shih YJ Wei TC Hsiue GH Zwitterionic sulfobetaine-grafted poly(vinylidene fluoride)
membrane with improved blood compatibility via atmospheric plasma-induced surface copolymerization ACS Appl
Mater Interfaces 201131228-37
[5] Shih YJ Chang Y Deratani A Damien Q Schizophrenic hemocompatible copolymers via switchable
thermoresponsive transition of nonioniczwitterionic block self-assembly in human blood Biomacromolecules
2012132849minus58
[6] Chang Y Shih YJ Lai CJ Kung HH Jiang S Ion-pair anchoring of self-assembled zwitterionic copolymer surfaces
with highly controlled blood compatibility Advanced Functional Materials 2013231100-10
13
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-2 Dr Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences
University of Tsukuba
Address Tennoudai 1-1-1 Tsukuba Ibaraki 305-8573 Japan
E-mailikedaimstsukubaacjp
Education March 1999 B S in Faculty of Engineering Kyoto University March 2001 MS in Graduate School of Engineering Department of Synthetic Chemistry and
Biological Chemistry Kyoto University March 2004 PhD in School of Engineering The University of Tokyo
Professional Experience 2004~2006 Advanced industrial science and technology (AIST) 2006~2008 Cytopathfinder Inc 2008~to date University of Tsukuba
Selected Publication (2010~) Y Ikeda J Katamachi H Kawasaki Y Nagasaki Novel protein PEGylation chemistry via glutalaldehydefunctionalized PEG Bioconjugate Chemistry 24 1824-1827 (2013) Y Ikeda D Kubota Y Nagasaki Design of sugar-oligonucleotide conjugates installed gold nanoparticle for effective delivery to hepatic parenchymal cells Colloid and Polymer Science 291 2959-2964 Y Ikeda H Kawasaki S Ichinohe Y Nagasaki Facile solid-phase synthesis of a highly stable poly(ethylene glycol)-oligonucleotide conjugate Journal of Materials Chemistry B 1 529-535(2013) Y Ikeda T Jomura U Horiuchi J Saeki K Yoshimoto T Ikeya Y Nagasaki Long-term survival and functional maintenance of hepatocytes by using a microfabricated cell array Colloid and Surface B Biointerface 97 97-100 2012 Y Ikeda Y Nagasaki PEGylation Technology in Nanomedicine Advances in Polymer Science 247 115-140 2012 Y Ikeda R Suzuki T Yoshitomi Y Nagasaki Novel oligonucleotide carrier possessing reactive oxygen species scavenging ability Macromolecular Bioscience 2011 11 344-351 Y Ikeda D Kubota Y Nagasaki Simple solid-phase synthesis and biological properties of carbohydrate-oligonucleotide conjugates modified at the 3rsquo terminus Bioconjugate Chem 2010 21 1685-1690
14
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-2 Sep 13 2014 (Sat) 0945-1015 at NTHU BMES R120
Chemical Modifications for the Developments of Next Generation Drugs
Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences University of
Tsukuba
Controlling of biodistribution and PKPD is a key issue for the development of drugsVariety of
technologies have been reported to improve those properties Those technologies include
nanoparticle formulation and PEGylation technology In my presentation I will show recent
chemical modification technologies which we developed to improve PKPD and distribution of
drugs
A novel chemistry for the PEGylated protein with a high activity
Several PEGylated proteins have been approved as therapeutic drugs In many cases PEGylated
protein has been synthesized by the conjugation reaction between PEG possessing activated ester and
amine(s) in the protein This reaction however often causes inactivation of PEGylated proteins In
this report we present a novel chemistry which enables the PEGylation of proteins under the mild
reaction condition PEGylated lysozyme prepared by the method developed increased the biological
activity of the PEGylated lysozyme more than 20 times compared with the PEGylated lysozyme
prepared by the conventional method
Design and development of novel hypoxically activated prodrugs
Tumor hypoxia is well known to promote mutagenesis invasiveness and to be associated with a
worse prognosis Although the treatment of the tumor hypoxia has been highly demanded resistance
to radiotherapy and anticancer chemotherapy have been serious problems The object of this study
was the development of hypoxically activated prodrugs which accumulate and act on cells at hypoxic
region of tumor Several conventional anti-cancer drugs including doxorubicin gemcitabine and 5FU
have been modified with 2-nitro imidazole derivative This modification enabled inactivation of drug
to reduce adverse effects under the normoxia condition and selective activation of prodrug under the
hypoxic condition
15
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-3 Prof Tzu-Wei Wang
Associate Professor
Department of Materials Science and Engineering and Institute of Biomedical
Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013
Office Delta Teaching Building R434
TEL +886-3-5715131 ext 33856
Email twwangmxnthuedutw Education 2006 PhD Institute of Biomedical Engineering National Taiwan University Taiwan
Professional Experience 2013 ndashpresent Associate Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2009 -2013 Assistant Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2007-2009 Postdoctoral Research Fellow Tissue Engineering Laboratories of Brigham and Womenrsquos
Hospital Harvard Medical School USA
Honor and awards (2009~) Young Plenary Award 2013 TERMIS-AP Symposium Shanghai China (2013) The 9th National Innovation Award Academic Research Category by Institute for Biotechnology and Medicine Industry Taiwan (2012) Young Investigator Award International Symposium of Materials on Regenerative Medicine Taiwan (2012 ISOMRM) Young Investigator Award 5th World Congress on Bioengineering the World Association for Chinese Biomedical Engineers Taiwan (WACBE 2011)
Selected Publication (2012~) Yang CS Wu HC Sun JS Hsiao HM Wang TW Thermo-induced shape memory PEG-PCL copolymer as dual drug-eluting biodegradable stent ACS Appl Mater Interfaces 2013 5 (21) 10985ndash10994 Yeh PH Sun JS Wu HC Hwang LH Wang TW Stimuli-responsive HA-PEI nanoparticles encapsulating endostatin plasmid for stem cell gene therapy RSC Advances 2013 3 (31) 12922 - 12932 Chen YY Wu HC Sun JS Dong GC Wang TW Injectable and thermoresponsive self-assembled nanocomposite hydrogel for long-term anticancer drug delivery Langmuir 201329(11)3721-3729 Cheng TY Wu HC Chang WH Huang MY Lee CH Wang TW Self-assembling functionalized nanopeptides for immediate hemostasis and accelerative liver tissue regeneration Nanoscale 2013 5 (7) 2734 - 2744 Chang YJ Tsai CJ Tseng FG Chen TJ Wang TW Micropatterned Stretching System for the Investigation of Mechanical Tension on Neural Stem Cells Behavior Nanomedicine Nanotechnology Biology and Medicine 20139345-355 Cheng TY Chen MH Chang WH Huang MY Wang TW Neural stem cells encapsulated in a functionalized self-assembling peptide hydrogel for brain tissue engineering Biomaterials 2013 34(8)2005-2016 Goh JH Wu HC Chen MH Chen MY Chang SC Wang TW Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages Acta Biomaterialia 20139(2)5170-5180 Huang YJ Wu HC Tai NH Wang TW Carbon Nanotube Rope with Electrical Stimulation Promotes the Differentiation and Maturity of Neural Stem Cells Small 20128(18) 2869ndash2877
16
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-3 Sep 13 2014 (Sat) 1015-1045 at NTHU BMES R120
Electrospun Composite Nanofibers with Staged Release of Multiple Angiogenic Growth Factors for Chronic Wound Healing
Tzu-Wei Wang
Department of Materials Science and Engineering and Institute of Biomedical Engineering National
Tsing Hua University
The objective of this research study is to develop collagen (Col) and hyaluronic acid (HA)
inter-stacking nanofibrous skin equivalent substitute with programmable release of multiple
angiogenic growth factors (VEGF PDGF bFGF and EGF) either directly embedded in the
nanofibers or encapsulated in the gelatin nanoparticles (GN) by electrospinning technology The
delivery of EGF and bFGF in early stage is expected to accelerate epithelialization and vasculature
sprouting while release of PDGF and VEGF in late stage is aimed for the induction of blood vessels
maturation The physiochemical characterizations report that the Col-HA-GN nanofibrous membrane
possesses mechanical property similar to human native skin The design of particle-in-fiber structure
allows growth factors for slow controlled release up to one month Cultured on biodegradable
Col-HA membrane with four kinds of growth factors (Col-HA w4GF) endothelial cells not only
increase in growth rate but also form better network of thread-like tubular structure Therapeutic
effect of Col-HA w4GF membrane on STZ-induced diabetic rats reveal accelerated wound closure
rate elevated collagen deposition and enhanced mature vessels by Massonrsquos trichrome stain and
immunohistochemical analysis respectively From the above the electrospun Col-HA-GN composite
nanofibrous skin substitute with stage-wise release pattern of multiple angiogenic factors could be a
promising bioengineered construct for the chronic wound healing in skin tissue regeneration
17
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-4 Assistant Prof Ryo Ishihara
Assistant Professor
Department of Materials Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
Tokyo University of Science Research Building 9th floor
TEL +81-3-5876-1415
FAX +81-3-5876-1415
Education 2012 PhD Department of Applied Chemistry and Biotechnology Chiba University Japan 2008 MS Department of Materials Technology Chiba University Japan 2006 BS Department of Materials Technology Chiba University Japan
Professional Experience 2014 ndashpresent Assistant Professor Department of Materials Science and Technology Tokyo
University of Science 2012 ndash2014 Postdoctral Researcher Bioengineering Laboratory RIKEN
Honor and awards Department chairmanlsquos award from Chiba University (2012)
Selected Publication (2010~) Simple Method for High-Density Impregnation of Aliquat 336 onto Porous Sheet and Binding Performance of Resulting Sheet for Palladium Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota Sep Sci Technol 49154-159 (2014) Effect of Dose on Mole Percentage of Polymer Brush and Root Grafted onto Porous Polyethylene Sheet by Radiation-Induced Graft Polymerization R Ishihara S Uchiyama H Ikezawa S Yamada H Hirota D Umeno K Saito Ind Eng Chem Res 5212582-12586 (2013) Determination of Mole Percentages of Brush and Root of Polymer Chain Grafted onto Porous Sheet S Uchiyama R Ishihara D Umeno K Saito S Yamada H Hirota S Asai J Chem Eng Japan 46414-419 (2013) Crosslinked-chelating Porous Sheet with High Dynamic Binding Capacity of Metal Ions G Wada R Ishihara K Miyoshi D Umeno K Saito S Yamada H Hirota Solv Extr Ion Exch 31210-220 (2013) Dependence of Lanthanide-Ion Binding Performance on HDEHP Concentration in HDEHP Impregnation to Porous Sheet R Ishihara S Asai S Otosaka S Yamada H Hirota K Miyoshi D Umeno K Saito Solv Extr Ion Exch 30171-180 (2012) Impregnation of TOPO onto Hydrophobic-Ligand-Containing Porous Sheet and Its Adsorptionelution Performance of Bismuth Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota React Funct Polym 70986-990 (2010)
18
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-4 Sep 13 2014 (Sat) 1110-1140 at NTHU BMES R120
Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip toward Point-of-Care Diagnosis
Ryo Ishihara Kazuo Hosokawa Mizuo Maeda
Bioengineering Laboratory RIKEN
MicroRNAs (miRNAs) are short and non-protein-coding single-stranded RNAs and have shown great promise for
cancer diagnosis Some miRNAs circulate in human body fluid with extremely low concentrations and its expression
profiling can detect and classify cancers in the human body [1] Point-of-care (POC) diagnosis requires short detection
time small required sample volume and portability of the device In various miRNA detection methods microfluidic
chip meets the requirements except the portability Hence we used our power-free pump-free microfluidic chip driven
by energy that is stored in degased PDMS to overcome those drawbacks which eliminates the need for external power
sources for fluid pumping [2] The pump-free pumping method is essential for microfluidic chip-based POC diagnosis In
our laboratory rapid and sensitive singleplex miRNA detection with laminar flow-assisted dendritic amplification (LFDA)
[3] on the pump-free microfluidic chip has been developed [4] In this study rapid and sensitive multiplex miRNA
detection on the pump-free microfluidic chip was demonstrated
Pump-free microchip for multiplex miRNA detection was prepared as follows First the PDMS part with a pair of
Y-shaped microchannels with 100 μm in width and 25 μm in height was fabricated Second three parallel-line-shaped
probe DNAs were patterned onto a glass surface Third the PDMS channels were attached onto the glass plate Finally
the chip was degassed in a vacuum chamber After the chip preparation target miRNAs were detected following three
steps (1) blocking (2) sandwich hybridization of the target miRNAs and biotinylated probe DNAs and (3) signal
amplification by LFDA MiR-16 miR-21-5p and miR-500a-3p were used as target miRNAs since they are known as
cancer biomarkers [5-7] Fluorescence signals were captured by CCD camera and analyzed by the software (ImageJ)
Bright lines appeared at the expected positions they appeared only on the areas with the respective probe DNA in which
the target miRNAs had been supplied These data prove that the LFDA successfully took place in a target
sequence-dependent manner Calibration curves were plotted from the fluorescence signals The data points of the
calibration curve were fitted with the four-parameter logistic function and limit-of-detections (LODs) were evaluated by
the 3σ criterion LODs of the miR-16 miR-21-5p and miR-500a-3p were 68 fM 15 pM and 150 fM respectively The
LODs are on the same order of magnitude as concentrations of miRNA in blood Multiplex detection was verified from
correspondence between the calibration curves of single and multiplex The required sample volume was 05 microL and
assay time was 20 min Because most of the existing methods take more than a few hours the rapidness small required
sample volume and portability of the device are ideal advantages for POC diagnosis
References
[1] PS Mitchell et al PNAS 105 (2008) 10513 [2] K Hosokawa et al Lab Chip 4 (2004) 181 [3] K Hosokawa et al Anal
Chem 79 (2007) 6000 [4] H Arata et al PLoS ONE 7 (2012) e48329 [5] MJ Lodes et al PLoS ONE 4 (2009) e6229
[6] Y Toiyama et al J Natl Cancer Inst 105 (2013) 849 [7] Y Yamamoto et al Biomarkers 14 (2009) 529
19
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-5 Dr Wen-Hsuan Chiang
Assistant Researcher
Department of Biomedical Engineering and Environmental Sciences
National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
TEL (886) 3-571-5131 ext 35576
Education 2009 PhD Department of Chemical Engineering National Chung Hsing University Taiwan Thesis Supervisor Professor Hsin-Cheng Chiu 2002 BS Department of Chemical Engineering Tatung University Taiwan Professional Experience 2013 ndashpresent Assistant Researcher Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University 2010 ndash2012 Postdoctoral Fellow Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
Areas of Research Expertise Biomaterials Smart Amphiphilic Copolymers Multifunctional Nanocarriers for Cancer Therapy and Imaging Nano Science and Interfacial Engineering
Selected Publication (2010~) Wen-Hsuan Chiang Wen-Chia Huang Ming-Yin Shen Che-Hsu Wang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Dual-Layered Nanogel-Coated Hollow LipidPolypeptide Conjugate Assemblies for Potential pH-Triggered Intracellular Drug Release PLOS ONE 2014 9 1-11 Wen-Hsuan Chiang Wen-Chia Huang Chien-Wen Chang Ming-Yin Shen Zong-Fu Shih Yi-Fong Huang Sung-Chyr Lin Hsin-Cheng Chiu Functionalized Polymersomes with Outlayered Polyelectrolyte Gels for Potential Tumor-Targeted Delivery of Multimodal Therapies and MR Imaging Journal of Controlled Release 2013 168 280-288 Wen-Hsuan Chiang Viet Thang Ho Hsin-Hung Chen Wen-Chia Huang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Superparamagnetic Hollow Hybrid Nanogels as a Potential Guidable Vehicle System of Stimuli-Mediated MR Imaging and Multiple Cancer Therapeutics Langmuir 2013 29 6434-6443 Wen-Hsuan Chiang Viet Thang Ho Wen-Chia Huang Yi-Fong Huang Chorng-Shyan Chern Hsin-Cheng Chiu Dual Stimuli-Responsive Polymeric Hollow Nanogels Designed as Carriers for Intracellular Triggered Drug Release Langmuir 2012 28 15056-15064 Yi-Fong HuangDagger Wen-Hsuan ChiangDagger Pei-Ling Tsai Chorng-Shyan Chern Hsin-Cheng Chiu Novel Hybrid Vesicles Co-Assembled from Cationic Lipid and PAAc-g-mPEG with pH-Triggered Transmembrane Channels for Controlled Drug Release Chemical Communications 2011 47 10978-10980
20
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-5 Sep 13 2014 (Sat) 1140-1210 at NTHU BMES R120 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and Imaging
Applications
Wen-Hsuan Chiang
Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
In order to promote therapeutic efficacy and minimize side effect equipping these nanocarriers with the
capability of controlling drug release in response to an appropriate stimulus is essentially required Acidic pH
as an internal stimulus is particular appealing because of the mildly acid pH encountered in tumor tissues and
the intracellular compartments such as endosomes and lysosomes Therefore the pH-responsive drug carriers
have been extensively developed for improving intracellular drug delivery To realize the pH-responsive drug
release we adopted a simple approach to design the lipidPEG-containing complex vesicles with pH-triggered
transmembrane channels as a chemotherapy drug doxorubicin (DOX) delivery carrier In this study the
complex vesicles were attained by spontaneous co-assembly of poly(acrylic acid)-g-poly(monomethoxy
ethylene glycol) (PAAc-g-mPEG) with a cationic lipid didodecyldimethylammonium bromide (DDAB) in
aqueous phase of pH 89 via electrostatic interactions Through the formation of unionized AAc-rich
transmembrance channels of complex vesicles in weak acidic environments the acid-triggered rapid drug
release can be achieved
On the other hand for simultaneously monitoring disease progression and biological response after
treatments we developed a novel tumor-targeting polymersome system capable of delivering magnetic
resonance imaging (MRI) and chemotherapy The DOX-loaded magnetic polymersomes were first attained by
the self-assembly of lipid-containing copolymer poly(AAc-co-distearin acrylate) in aqueous solution
containing citric acid-coated superparamagnetic iron oxide nanoparticles (SPIONs) and followed by DOX
loading via electrostatic attraction To further functionalize these vesicles with superior in vivo colloidal
stability pH-tunable drug release and active tumor-targeting chitosan and poly( -glutamic
acid-co- -glutamyl oxysuccinimide)-g-PEG-folate (FA) were deposited in sequence onto the assembly outer
surfaces The interfacial nanogel layers via electrostatic interactions and in-situ covalent cross-linking were
thus produced Triggerable release of the encapsulated DOX was governed by dual external stimuli pH and
temperature When these theranostic NCPs were effectively internalized by HeLa cells via FA
receptor-mediated endocytosis and then exposed to high frequency magnetic fields (HFMF) the combined
effects of both pH and magnetic hyperthermia-triggered drug release and thermo-therapy resulted in greater
cytotoxicity than the treatment by DOX alone By virtue of the SPION clustering effect in the assembly inner
aqueous compartments the SPIONDOX-loaded NCPs displayed an r2 relaxivity value higher than Resovist
a commercial SPION-based T2 contrast agent The high magnetic relaxivity of the tumor-targeting NCPs
coupled with their enhanced cellular uptake considerably promoted the MRI contrast of targeted cancer cells
These results demonstrate the great potential of the FA-decorated SPIONDOX-loaded NCPs as an advanced
cancer theranostic nanodevice
21
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-1 Prof Hao-Li Liu Professor and Director
Department of Electrical Engineering
Chang Gung University
Phone +886-3-2118800 ext 5677
Fax +886-3-2118026
E-mail haoliliumailcguedutw
Education 2003 PhD National Taiwan University Taipei TAIWAN 1998 M S National Taiwan University Taipei TAIWAN 1996 B S National Taipei University of Technology TAIWAN
Professional Experience 2012-present Director Dept of Electrical Engineering Chang Gung Univ Taiwan 2011-present Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2008 Associate Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2005 ndash2008 Assistant Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2004 ndash2005 Research Fellow Department of Radiology Brigham amp Womenrsquos Hospital Harvard Medical School MA USA
Honor and awards (2009~) 2013 Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) 2013 The 2013 Frederick Lizzi Award International Society of Therapeutic Ultrasound 2011 Distinguished Tech-Coop Award (長庚大學優良教師技合獎) Chang-Gung University 2011 Wu Ta-You Memorial Award (吳大猷先生紀念獎) National Science Council Taiwan 2011 2010 Distinguished Research Award (長庚大學優良教師研究獎) Chang-Gung University
Selected Publication (2010~) HW Yang MY Hua TL Hwang KJ Lin CY Huang RY Tsai CCM Ma PH Hsu SP Wey PW Hsu PY Chen YC Huang YJ Lu TC Yen LY Feng CW Lin HL Liu KC Wei Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide Advanced Materials Vol 25 No 26 pp3605-3611 2013 HL Liu CH Fan CY Ting and CK Yeh Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors Theranostics Vol 4 No 4 pp432-444 2014 KC Wei PC Chu HYJ Wang CY Huang PY Chen HC Tsai YJ Lu IC Tseng PY Lee TC Yen and HL Liu Focused Ultrasound-induced BloodndashBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment A Preclinical Study PLoS ONE Vol 8 No 3 pp e58995 2013 P-H Hsu K-C Wei C-Y Huang C-J Wen T-C Yen C-L Liu Y-T Lin J-C Chen C-R Shen and H-L Liu Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound PLoS ONE Vol 8 No 2 pp e57682 2013 H-L Liu M-Y Hua H-W Yang C-Y Huang P-C Chu J-S Wua I-C Tseng J-J Wang T-C Yen P-Y Chen and K-C Wei ldquoMagnetic resonance monitoring of focused ultrasoundmagnetic nanoparticle targeting delivery of therapeutic agents to the brainrdquo Proceedings of National Academy of Science USA Vol 107 No 34 pp15205-15210 2010 H-L Liu M-Y Hua P-Y Chen P-C Chu C-H Pan H-W Yang C-Y Huang J-J Wang T-C Yen and K-C Wei ldquoBloodndashBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatmentrdquo Radiology Vol 255 No 2 pp 415-425 2010 H-L Liu Y-Y Wai P-H Hsu L-A Lyu J-S Wu C-R Shen J-C Chen T-C Yen and J-J Wang ldquoIn Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Bloodndashbrain Barrier with Focused Ultrasound A Magnetic Resonance Imaging Studyrdquo Journal of Cerebral Blood Flow amp Metabolism Vol 30 pp 168-177 2010
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
6
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
List of Invited Speaker
Session A Biomaterials Prof Yung Chang (張雍) (Professor Dept of Chemical Engineering Chung Yuan University)
Prof Yutaka Ikeda (池田豊) (Professor Dept of Mater Sci University of Tsukuba Japan)
Prof Tzu-Wei Wang (王子威) (Professor Dept of Materials Science and Engineering National
Tsing Hua University)
Prof Ryo Ishihara (石原量) (Assistant Professor Dept of Materials Science and Technology
University of Tsukuba Japan)
Dr Wen-Hsuan Chiang (姜文軒) (Assistant Researcher Dept of Biomedical Engineering and
Environmental Sciences National Tsing Hua University)
Session B Biomedical Imaging Prof Hao-Li Liu (劉浩澧) (Dept of Electrical Engineering Chang Gung University Taiwan)
Dr Ichio Aoki (青木伊知男) (Molecular Imagining Center National Institute of Radiological
Sciences Japan)
Prof Meng-Lin Li (李夢麟) (Associate Professor Dept of Electrical Engineering National Tsing
Hua University)
Prof Tomoko Masaike (政池知子) (Associate Professor Tokyo University of Science Japan)
Prof Chih-Chung Huang(黃執中 ) (Assistant Professor Dept of Biomedical Engineering
National Cheng Kung University)
Prof Masao Kamimura ( 上村真生 ) (Assistant Professor Dept of Materials Science and
Technology University of Tsukuba Japan)
Session C Science and Technology for Environment amp Energy Prof Keishi Nishio (西尾圭史 ) (Professor Dept of Materials Science and Technology
University of Tsukuba)
Prof Hsing-Cheng Hsi (席行正) (Associate Professor Graduate Institute of Environmental
Engineering National Taiwan University)
Prof Kenjiro Fujimoto(藤本憲次郎 )(Department of Pure and Applied Chemistry Tokyo
University of Science)
Prof Fu-Hsiang Ko (柯富祥) (Professor Institute of Nanotechnology National Chiao Tung
University)
Prof Naoto Kitamura (北村尚斗 ) (Associate Professor Department of Pure and Applied
Chemistry Tokyo University of Science)
Prof Zong-Hong Lin (林宗宏 ) (Assistant Professor Institute of Biomedical Engineering
National Tsing Hua University)
7
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Organizer
Department of Biomedical Engineering and Environmental Sciences (BMES)
National Tsing HuaUniversity (NTHU) Taiwan
清華大學 生醫工程與環境科學系
Department of Materials Science and Technologies
Tokyo University of Science (TUS) Japan
東京理科大學 材料科學與技術系
Co-Organizer
Engineering and Technology Promotion Center
National Science Council (NSC) Taiwan
國家科學委員會 工程科技推展中心
College of Nuclear Science
National Tsing Hua Univeristy (NTHU) Taiwan
清華大學 原子科學院
8
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Map
9
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Program
September 12 (Fri) 2014
Time Agenda Speaker
1900~2100 Welcome and Opening Ceremony (Hall of Fame)
September 13 (Sat) 2014 Place NTHU BMES
Time Agenda Speaker
0830~0900 Registration (Entrance Hall NTHU BMES)
0900~0915 Opening Remarks Symposium Chairs
Session A Biomaterials Moderator Hsin-Cheng Chiu (NTHU) Ryo Ishihara (TUS)
0915~0945 Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes (Keynote)
Prof Yung Chang張
雍
0945~1015 Chemical Modifications for the Developments of Next Generation
Drugs (Keynote)
Prof Yutaka Ikeda
池田豊
1015~1045 Electrospun Composite Nanofibers with Staged Release of Multiple
Angiogenic Growth Factors for Chronic Wound Healing (Keynote)
Prof Tzu-Wei Wang
王子威
1045~1110 Break
1110~1140 Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip
toward Point-of-Care Diagnosis (invited)
Prof Ryo Ishihara石
原量
1140~1210 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and
Imaging Applications (Invited)
Dr Wen-Hsuan
Chiang姜文軒
1200~1330 Lunch
Session B Biomedical Imaging Moderator Chih-Kuang Yeh (NTHU) Kohei Soga (TUS)
1320~1400 Focused-Ultrasound Brain-Drug Delivery Approach and
Application (Keynote)
Prof Hao-Li Liu劉
浩澧
1400~1440 Responsive and Theranostic Nano-Contrast Agents for Preclinical
MR Imaging (Keynote)
Dr Ichio Aoki青木
伊知男
1440~1510 Observation of Single-Molecule Enzymes through Probes under the
Optical Microscope (Keynote)
Prof Tomoko
Masaike政池知子
1510~1630 Break
1630~1710 Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing
SPIO Nanoparticles Ultrasonically (Invited)
Prof Meng-Lin Li
李夢麟
1710~1740 High resolution ultrasound elastography for medical applications
(Invited)
Prof Chih-Chung
Huang黃執中
1740~1810 Biofunctional Polymers for Application of Ceramic Nanoparticles
for Fluorescence Bioimaging (Invited)
Prof Masao
Kamimura上村真生
1900~ Banquet (合口味)
10
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
September 14 (Sun) 2014 Place NTHU BMES
Time Agenda Speaker
0845~0900 Registration
Session C Science and Technology for Environment amp Energy
Moderator Yu-Fen Huang (NTHU) Keishi Nishio (TUS)
0900~0930 Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed
Tungsten Oxide Thin Films for Hydrogen Gas Sensor (Keynote)
Prof Keishi Nishio
西尾圭史
0930~1000 Control of low-concentration gaseous mercury from stationary
sources via adsorption and oxidation (Keynote)
Prof Hsing-Cheng
His席行正
1000~1030 High-Throughput Functional Materials Exploration by
Combinatorial WetDry Process (Keynote)
Prof Kenjiro
Fujimoto藤本憲次
郎
1030~1050 Break
1050~1120 Facile Manufacturing on Energy-efficient Devices with Flexibility
and Antireflection (Invited)
Prof Fu-Hsiang Ko
柯富祥
1120~1150 Proton Distribution and Dynamics in BaZrO3-Based Proton
Conductor for Solid Oxide Fuel Cell (Invited)
Prof Naoto
Kitamura北村尚斗
1150~1220 Harvesting Water Energy by a Sequential Contact-Electrification and
Electrostatic-Induction Process (Invited)
Prof Zong-Hong
Lin林宗宏
1210~1330 Lunch
Poster Session
1330~1530 Poster Session
1600~1800 Move to I-Lan
1800~2000 Luodong Night Market
2000 National Center for Traditional Art I-Lan (宜蘭傳藝)
September 15 (Mon) 2014 Place I-Lan
Time Agenda Speaker
0700~0800 Breakfast
0845~0910 Closing Remarks
(National Center for Traditional Art I-Lan)
0910~1500 Visit National Center for Traditional Art
1150~1330 Lunch
1530 Move to Taipei Railway Station or Hsinchu
11
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker
Invited Speaker A-1 Prof Yung Chang
Distinguished Professor
Department of Chemical Engineering
Deputy Director RampD Center for Membrane Technology
Chung Yuan Christian University
Address Jhong-Li Taoyuan 320 Taiwan
TEL (886) 265-4122
FAX (886) 265-4190
Education 2004 PhD Chemical Engineering National Taiwan University Taiwan 2000 MS Chemical Engineering National Taiwan University Taiwan 1998 BS Chemical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013-present Deputy Director RampD Center for Membrane Technology Chung Yuan Christian
University 2013-present Distinguished Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2013-present Professor Department of Chemical Engineering Chung Yuan Christian University
Taiwan 2009-2013 Associate Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2006-2009 Assistant Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2005-2006 Postdoctoral Fellow Chemical Engineering University of Washington USA 2004-2005 Postdoctoral Fellow Chemical Engineering National Taiwan University Taiwan
Honor and awards (2010~) 2010 Yung Investigator Award of Chemical Engineering (Taiwan Institute of Chemical Engineers) 2010 Yung Investigator Award of Materials on Regenerative Medicine (National Health Research
Institutes Taiwan) 2011 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan) 2011 Outstanding Research Award of Chemical Engineering (LCY Chemical Corp) 2012 NSC Wu Da-Yu Award (National science council Taiwan) 2012 NSC Outstanding AcademicIndustrial Cooperation Award (National science council) 2013 Yung Investigator Award of Polymer Science (Taiwan Institute of Polymer Science) 2013 JCS The Distinguished Lectureship Award Biomaterial Research (Japan Chemical Society) 2013 Ukraine International Invention Exhibition Gold Medal (Ukraine Invention Society) 2014 Pittsburgh International Invention Exhibition Gold Medal (USA Invention Society) 2014 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan)
12
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-1 Sep 13 2014 (Sat) 0915-0945 at NTHU BMES R120
Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes
Chung Yuan
RampD Center for Membrane Technology and Department of Chemical Engineering Christian
University Chung-Li Taoyuan 320 Taiwan
Zwitterionic polymeric interface resisting the adsorption of plasma proteins is important in the
development of blood-contacting biomaterials in such applications as blood collection devices
antithrombogenic implants hemodialysis membranes drug-delivery carriers and diagnostic
biosensors Previous studies showed that the control of surface charge neutrality is important for a
zwitterionic surface with effective protein-resistant properties Importantly it was further reported
that the mixed-charge formulation in self-assembled monolayers copolymer hydrogels and
polymeric brushes provide a new avenue to achieve nonfouling surfaces with the prevention of
nonspecific protein adsorption if the charge balance can be well controlled This talk will cover three
major studies
Bio-inert nature of biomimetic zwitterionicpseudozwitterionic structures
Blood-Inert
Surfaces via ion-pair anchoring of zwitterionic copolymer brushes in human whole blood Surface
zwitterionization of membrenaes in novel biomedical applications
[1] Chang Y Liao SC Higuchi A Ruaan RC Chu CW Chen WY A highly stable nonbiofouling surface with
well-packed grafted zwitterionic polysulfobetaine for plasma protein repulsion Langmuir 2008245453-58
[2] Chiag YC Chang Y Higuchi A Chen WY Ruaan RC Sulfobetaine-grafted poly(vinylidene fluroride) ultrafiltration
membranes exhibit excellent antifouling property Journal of Membrane Science 2009339151-9
[3] Chang Y Yandi W Chen WY Shih YJ Yang CC Chang Y Ling QD Higuchi A Tunable bioadhesive copolymer
hydrogels of thermoresponsive poly(N-isopropyl acrylamide) containing zwitterionic polysulfobetaine
Biomacromolecules 2010111101-10
[4] Chang Y Chang WJ Shih YJ Wei TC Hsiue GH Zwitterionic sulfobetaine-grafted poly(vinylidene fluoride)
membrane with improved blood compatibility via atmospheric plasma-induced surface copolymerization ACS Appl
Mater Interfaces 201131228-37
[5] Shih YJ Chang Y Deratani A Damien Q Schizophrenic hemocompatible copolymers via switchable
thermoresponsive transition of nonioniczwitterionic block self-assembly in human blood Biomacromolecules
2012132849minus58
[6] Chang Y Shih YJ Lai CJ Kung HH Jiang S Ion-pair anchoring of self-assembled zwitterionic copolymer surfaces
with highly controlled blood compatibility Advanced Functional Materials 2013231100-10
13
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-2 Dr Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences
University of Tsukuba
Address Tennoudai 1-1-1 Tsukuba Ibaraki 305-8573 Japan
E-mailikedaimstsukubaacjp
Education March 1999 B S in Faculty of Engineering Kyoto University March 2001 MS in Graduate School of Engineering Department of Synthetic Chemistry and
Biological Chemistry Kyoto University March 2004 PhD in School of Engineering The University of Tokyo
Professional Experience 2004~2006 Advanced industrial science and technology (AIST) 2006~2008 Cytopathfinder Inc 2008~to date University of Tsukuba
Selected Publication (2010~) Y Ikeda J Katamachi H Kawasaki Y Nagasaki Novel protein PEGylation chemistry via glutalaldehydefunctionalized PEG Bioconjugate Chemistry 24 1824-1827 (2013) Y Ikeda D Kubota Y Nagasaki Design of sugar-oligonucleotide conjugates installed gold nanoparticle for effective delivery to hepatic parenchymal cells Colloid and Polymer Science 291 2959-2964 Y Ikeda H Kawasaki S Ichinohe Y Nagasaki Facile solid-phase synthesis of a highly stable poly(ethylene glycol)-oligonucleotide conjugate Journal of Materials Chemistry B 1 529-535(2013) Y Ikeda T Jomura U Horiuchi J Saeki K Yoshimoto T Ikeya Y Nagasaki Long-term survival and functional maintenance of hepatocytes by using a microfabricated cell array Colloid and Surface B Biointerface 97 97-100 2012 Y Ikeda Y Nagasaki PEGylation Technology in Nanomedicine Advances in Polymer Science 247 115-140 2012 Y Ikeda R Suzuki T Yoshitomi Y Nagasaki Novel oligonucleotide carrier possessing reactive oxygen species scavenging ability Macromolecular Bioscience 2011 11 344-351 Y Ikeda D Kubota Y Nagasaki Simple solid-phase synthesis and biological properties of carbohydrate-oligonucleotide conjugates modified at the 3rsquo terminus Bioconjugate Chem 2010 21 1685-1690
14
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-2 Sep 13 2014 (Sat) 0945-1015 at NTHU BMES R120
Chemical Modifications for the Developments of Next Generation Drugs
Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences University of
Tsukuba
Controlling of biodistribution and PKPD is a key issue for the development of drugsVariety of
technologies have been reported to improve those properties Those technologies include
nanoparticle formulation and PEGylation technology In my presentation I will show recent
chemical modification technologies which we developed to improve PKPD and distribution of
drugs
A novel chemistry for the PEGylated protein with a high activity
Several PEGylated proteins have been approved as therapeutic drugs In many cases PEGylated
protein has been synthesized by the conjugation reaction between PEG possessing activated ester and
amine(s) in the protein This reaction however often causes inactivation of PEGylated proteins In
this report we present a novel chemistry which enables the PEGylation of proteins under the mild
reaction condition PEGylated lysozyme prepared by the method developed increased the biological
activity of the PEGylated lysozyme more than 20 times compared with the PEGylated lysozyme
prepared by the conventional method
Design and development of novel hypoxically activated prodrugs
Tumor hypoxia is well known to promote mutagenesis invasiveness and to be associated with a
worse prognosis Although the treatment of the tumor hypoxia has been highly demanded resistance
to radiotherapy and anticancer chemotherapy have been serious problems The object of this study
was the development of hypoxically activated prodrugs which accumulate and act on cells at hypoxic
region of tumor Several conventional anti-cancer drugs including doxorubicin gemcitabine and 5FU
have been modified with 2-nitro imidazole derivative This modification enabled inactivation of drug
to reduce adverse effects under the normoxia condition and selective activation of prodrug under the
hypoxic condition
15
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-3 Prof Tzu-Wei Wang
Associate Professor
Department of Materials Science and Engineering and Institute of Biomedical
Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013
Office Delta Teaching Building R434
TEL +886-3-5715131 ext 33856
Email twwangmxnthuedutw Education 2006 PhD Institute of Biomedical Engineering National Taiwan University Taiwan
Professional Experience 2013 ndashpresent Associate Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2009 -2013 Assistant Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2007-2009 Postdoctoral Research Fellow Tissue Engineering Laboratories of Brigham and Womenrsquos
Hospital Harvard Medical School USA
Honor and awards (2009~) Young Plenary Award 2013 TERMIS-AP Symposium Shanghai China (2013) The 9th National Innovation Award Academic Research Category by Institute for Biotechnology and Medicine Industry Taiwan (2012) Young Investigator Award International Symposium of Materials on Regenerative Medicine Taiwan (2012 ISOMRM) Young Investigator Award 5th World Congress on Bioengineering the World Association for Chinese Biomedical Engineers Taiwan (WACBE 2011)
Selected Publication (2012~) Yang CS Wu HC Sun JS Hsiao HM Wang TW Thermo-induced shape memory PEG-PCL copolymer as dual drug-eluting biodegradable stent ACS Appl Mater Interfaces 2013 5 (21) 10985ndash10994 Yeh PH Sun JS Wu HC Hwang LH Wang TW Stimuli-responsive HA-PEI nanoparticles encapsulating endostatin plasmid for stem cell gene therapy RSC Advances 2013 3 (31) 12922 - 12932 Chen YY Wu HC Sun JS Dong GC Wang TW Injectable and thermoresponsive self-assembled nanocomposite hydrogel for long-term anticancer drug delivery Langmuir 201329(11)3721-3729 Cheng TY Wu HC Chang WH Huang MY Lee CH Wang TW Self-assembling functionalized nanopeptides for immediate hemostasis and accelerative liver tissue regeneration Nanoscale 2013 5 (7) 2734 - 2744 Chang YJ Tsai CJ Tseng FG Chen TJ Wang TW Micropatterned Stretching System for the Investigation of Mechanical Tension on Neural Stem Cells Behavior Nanomedicine Nanotechnology Biology and Medicine 20139345-355 Cheng TY Chen MH Chang WH Huang MY Wang TW Neural stem cells encapsulated in a functionalized self-assembling peptide hydrogel for brain tissue engineering Biomaterials 2013 34(8)2005-2016 Goh JH Wu HC Chen MH Chen MY Chang SC Wang TW Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages Acta Biomaterialia 20139(2)5170-5180 Huang YJ Wu HC Tai NH Wang TW Carbon Nanotube Rope with Electrical Stimulation Promotes the Differentiation and Maturity of Neural Stem Cells Small 20128(18) 2869ndash2877
16
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-3 Sep 13 2014 (Sat) 1015-1045 at NTHU BMES R120
Electrospun Composite Nanofibers with Staged Release of Multiple Angiogenic Growth Factors for Chronic Wound Healing
Tzu-Wei Wang
Department of Materials Science and Engineering and Institute of Biomedical Engineering National
Tsing Hua University
The objective of this research study is to develop collagen (Col) and hyaluronic acid (HA)
inter-stacking nanofibrous skin equivalent substitute with programmable release of multiple
angiogenic growth factors (VEGF PDGF bFGF and EGF) either directly embedded in the
nanofibers or encapsulated in the gelatin nanoparticles (GN) by electrospinning technology The
delivery of EGF and bFGF in early stage is expected to accelerate epithelialization and vasculature
sprouting while release of PDGF and VEGF in late stage is aimed for the induction of blood vessels
maturation The physiochemical characterizations report that the Col-HA-GN nanofibrous membrane
possesses mechanical property similar to human native skin The design of particle-in-fiber structure
allows growth factors for slow controlled release up to one month Cultured on biodegradable
Col-HA membrane with four kinds of growth factors (Col-HA w4GF) endothelial cells not only
increase in growth rate but also form better network of thread-like tubular structure Therapeutic
effect of Col-HA w4GF membrane on STZ-induced diabetic rats reveal accelerated wound closure
rate elevated collagen deposition and enhanced mature vessels by Massonrsquos trichrome stain and
immunohistochemical analysis respectively From the above the electrospun Col-HA-GN composite
nanofibrous skin substitute with stage-wise release pattern of multiple angiogenic factors could be a
promising bioengineered construct for the chronic wound healing in skin tissue regeneration
17
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-4 Assistant Prof Ryo Ishihara
Assistant Professor
Department of Materials Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
Tokyo University of Science Research Building 9th floor
TEL +81-3-5876-1415
FAX +81-3-5876-1415
Education 2012 PhD Department of Applied Chemistry and Biotechnology Chiba University Japan 2008 MS Department of Materials Technology Chiba University Japan 2006 BS Department of Materials Technology Chiba University Japan
Professional Experience 2014 ndashpresent Assistant Professor Department of Materials Science and Technology Tokyo
University of Science 2012 ndash2014 Postdoctral Researcher Bioengineering Laboratory RIKEN
Honor and awards Department chairmanlsquos award from Chiba University (2012)
Selected Publication (2010~) Simple Method for High-Density Impregnation of Aliquat 336 onto Porous Sheet and Binding Performance of Resulting Sheet for Palladium Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota Sep Sci Technol 49154-159 (2014) Effect of Dose on Mole Percentage of Polymer Brush and Root Grafted onto Porous Polyethylene Sheet by Radiation-Induced Graft Polymerization R Ishihara S Uchiyama H Ikezawa S Yamada H Hirota D Umeno K Saito Ind Eng Chem Res 5212582-12586 (2013) Determination of Mole Percentages of Brush and Root of Polymer Chain Grafted onto Porous Sheet S Uchiyama R Ishihara D Umeno K Saito S Yamada H Hirota S Asai J Chem Eng Japan 46414-419 (2013) Crosslinked-chelating Porous Sheet with High Dynamic Binding Capacity of Metal Ions G Wada R Ishihara K Miyoshi D Umeno K Saito S Yamada H Hirota Solv Extr Ion Exch 31210-220 (2013) Dependence of Lanthanide-Ion Binding Performance on HDEHP Concentration in HDEHP Impregnation to Porous Sheet R Ishihara S Asai S Otosaka S Yamada H Hirota K Miyoshi D Umeno K Saito Solv Extr Ion Exch 30171-180 (2012) Impregnation of TOPO onto Hydrophobic-Ligand-Containing Porous Sheet and Its Adsorptionelution Performance of Bismuth Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota React Funct Polym 70986-990 (2010)
18
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-4 Sep 13 2014 (Sat) 1110-1140 at NTHU BMES R120
Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip toward Point-of-Care Diagnosis
Ryo Ishihara Kazuo Hosokawa Mizuo Maeda
Bioengineering Laboratory RIKEN
MicroRNAs (miRNAs) are short and non-protein-coding single-stranded RNAs and have shown great promise for
cancer diagnosis Some miRNAs circulate in human body fluid with extremely low concentrations and its expression
profiling can detect and classify cancers in the human body [1] Point-of-care (POC) diagnosis requires short detection
time small required sample volume and portability of the device In various miRNA detection methods microfluidic
chip meets the requirements except the portability Hence we used our power-free pump-free microfluidic chip driven
by energy that is stored in degased PDMS to overcome those drawbacks which eliminates the need for external power
sources for fluid pumping [2] The pump-free pumping method is essential for microfluidic chip-based POC diagnosis In
our laboratory rapid and sensitive singleplex miRNA detection with laminar flow-assisted dendritic amplification (LFDA)
[3] on the pump-free microfluidic chip has been developed [4] In this study rapid and sensitive multiplex miRNA
detection on the pump-free microfluidic chip was demonstrated
Pump-free microchip for multiplex miRNA detection was prepared as follows First the PDMS part with a pair of
Y-shaped microchannels with 100 μm in width and 25 μm in height was fabricated Second three parallel-line-shaped
probe DNAs were patterned onto a glass surface Third the PDMS channels were attached onto the glass plate Finally
the chip was degassed in a vacuum chamber After the chip preparation target miRNAs were detected following three
steps (1) blocking (2) sandwich hybridization of the target miRNAs and biotinylated probe DNAs and (3) signal
amplification by LFDA MiR-16 miR-21-5p and miR-500a-3p were used as target miRNAs since they are known as
cancer biomarkers [5-7] Fluorescence signals were captured by CCD camera and analyzed by the software (ImageJ)
Bright lines appeared at the expected positions they appeared only on the areas with the respective probe DNA in which
the target miRNAs had been supplied These data prove that the LFDA successfully took place in a target
sequence-dependent manner Calibration curves were plotted from the fluorescence signals The data points of the
calibration curve were fitted with the four-parameter logistic function and limit-of-detections (LODs) were evaluated by
the 3σ criterion LODs of the miR-16 miR-21-5p and miR-500a-3p were 68 fM 15 pM and 150 fM respectively The
LODs are on the same order of magnitude as concentrations of miRNA in blood Multiplex detection was verified from
correspondence between the calibration curves of single and multiplex The required sample volume was 05 microL and
assay time was 20 min Because most of the existing methods take more than a few hours the rapidness small required
sample volume and portability of the device are ideal advantages for POC diagnosis
References
[1] PS Mitchell et al PNAS 105 (2008) 10513 [2] K Hosokawa et al Lab Chip 4 (2004) 181 [3] K Hosokawa et al Anal
Chem 79 (2007) 6000 [4] H Arata et al PLoS ONE 7 (2012) e48329 [5] MJ Lodes et al PLoS ONE 4 (2009) e6229
[6] Y Toiyama et al J Natl Cancer Inst 105 (2013) 849 [7] Y Yamamoto et al Biomarkers 14 (2009) 529
19
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-5 Dr Wen-Hsuan Chiang
Assistant Researcher
Department of Biomedical Engineering and Environmental Sciences
National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
TEL (886) 3-571-5131 ext 35576
Education 2009 PhD Department of Chemical Engineering National Chung Hsing University Taiwan Thesis Supervisor Professor Hsin-Cheng Chiu 2002 BS Department of Chemical Engineering Tatung University Taiwan Professional Experience 2013 ndashpresent Assistant Researcher Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University 2010 ndash2012 Postdoctoral Fellow Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
Areas of Research Expertise Biomaterials Smart Amphiphilic Copolymers Multifunctional Nanocarriers for Cancer Therapy and Imaging Nano Science and Interfacial Engineering
Selected Publication (2010~) Wen-Hsuan Chiang Wen-Chia Huang Ming-Yin Shen Che-Hsu Wang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Dual-Layered Nanogel-Coated Hollow LipidPolypeptide Conjugate Assemblies for Potential pH-Triggered Intracellular Drug Release PLOS ONE 2014 9 1-11 Wen-Hsuan Chiang Wen-Chia Huang Chien-Wen Chang Ming-Yin Shen Zong-Fu Shih Yi-Fong Huang Sung-Chyr Lin Hsin-Cheng Chiu Functionalized Polymersomes with Outlayered Polyelectrolyte Gels for Potential Tumor-Targeted Delivery of Multimodal Therapies and MR Imaging Journal of Controlled Release 2013 168 280-288 Wen-Hsuan Chiang Viet Thang Ho Hsin-Hung Chen Wen-Chia Huang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Superparamagnetic Hollow Hybrid Nanogels as a Potential Guidable Vehicle System of Stimuli-Mediated MR Imaging and Multiple Cancer Therapeutics Langmuir 2013 29 6434-6443 Wen-Hsuan Chiang Viet Thang Ho Wen-Chia Huang Yi-Fong Huang Chorng-Shyan Chern Hsin-Cheng Chiu Dual Stimuli-Responsive Polymeric Hollow Nanogels Designed as Carriers for Intracellular Triggered Drug Release Langmuir 2012 28 15056-15064 Yi-Fong HuangDagger Wen-Hsuan ChiangDagger Pei-Ling Tsai Chorng-Shyan Chern Hsin-Cheng Chiu Novel Hybrid Vesicles Co-Assembled from Cationic Lipid and PAAc-g-mPEG with pH-Triggered Transmembrane Channels for Controlled Drug Release Chemical Communications 2011 47 10978-10980
20
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-5 Sep 13 2014 (Sat) 1140-1210 at NTHU BMES R120 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and Imaging
Applications
Wen-Hsuan Chiang
Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
In order to promote therapeutic efficacy and minimize side effect equipping these nanocarriers with the
capability of controlling drug release in response to an appropriate stimulus is essentially required Acidic pH
as an internal stimulus is particular appealing because of the mildly acid pH encountered in tumor tissues and
the intracellular compartments such as endosomes and lysosomes Therefore the pH-responsive drug carriers
have been extensively developed for improving intracellular drug delivery To realize the pH-responsive drug
release we adopted a simple approach to design the lipidPEG-containing complex vesicles with pH-triggered
transmembrane channels as a chemotherapy drug doxorubicin (DOX) delivery carrier In this study the
complex vesicles were attained by spontaneous co-assembly of poly(acrylic acid)-g-poly(monomethoxy
ethylene glycol) (PAAc-g-mPEG) with a cationic lipid didodecyldimethylammonium bromide (DDAB) in
aqueous phase of pH 89 via electrostatic interactions Through the formation of unionized AAc-rich
transmembrance channels of complex vesicles in weak acidic environments the acid-triggered rapid drug
release can be achieved
On the other hand for simultaneously monitoring disease progression and biological response after
treatments we developed a novel tumor-targeting polymersome system capable of delivering magnetic
resonance imaging (MRI) and chemotherapy The DOX-loaded magnetic polymersomes were first attained by
the self-assembly of lipid-containing copolymer poly(AAc-co-distearin acrylate) in aqueous solution
containing citric acid-coated superparamagnetic iron oxide nanoparticles (SPIONs) and followed by DOX
loading via electrostatic attraction To further functionalize these vesicles with superior in vivo colloidal
stability pH-tunable drug release and active tumor-targeting chitosan and poly( -glutamic
acid-co- -glutamyl oxysuccinimide)-g-PEG-folate (FA) were deposited in sequence onto the assembly outer
surfaces The interfacial nanogel layers via electrostatic interactions and in-situ covalent cross-linking were
thus produced Triggerable release of the encapsulated DOX was governed by dual external stimuli pH and
temperature When these theranostic NCPs were effectively internalized by HeLa cells via FA
receptor-mediated endocytosis and then exposed to high frequency magnetic fields (HFMF) the combined
effects of both pH and magnetic hyperthermia-triggered drug release and thermo-therapy resulted in greater
cytotoxicity than the treatment by DOX alone By virtue of the SPION clustering effect in the assembly inner
aqueous compartments the SPIONDOX-loaded NCPs displayed an r2 relaxivity value higher than Resovist
a commercial SPION-based T2 contrast agent The high magnetic relaxivity of the tumor-targeting NCPs
coupled with their enhanced cellular uptake considerably promoted the MRI contrast of targeted cancer cells
These results demonstrate the great potential of the FA-decorated SPIONDOX-loaded NCPs as an advanced
cancer theranostic nanodevice
21
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-1 Prof Hao-Li Liu Professor and Director
Department of Electrical Engineering
Chang Gung University
Phone +886-3-2118800 ext 5677
Fax +886-3-2118026
E-mail haoliliumailcguedutw
Education 2003 PhD National Taiwan University Taipei TAIWAN 1998 M S National Taiwan University Taipei TAIWAN 1996 B S National Taipei University of Technology TAIWAN
Professional Experience 2012-present Director Dept of Electrical Engineering Chang Gung Univ Taiwan 2011-present Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2008 Associate Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2005 ndash2008 Assistant Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2004 ndash2005 Research Fellow Department of Radiology Brigham amp Womenrsquos Hospital Harvard Medical School MA USA
Honor and awards (2009~) 2013 Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) 2013 The 2013 Frederick Lizzi Award International Society of Therapeutic Ultrasound 2011 Distinguished Tech-Coop Award (長庚大學優良教師技合獎) Chang-Gung University 2011 Wu Ta-You Memorial Award (吳大猷先生紀念獎) National Science Council Taiwan 2011 2010 Distinguished Research Award (長庚大學優良教師研究獎) Chang-Gung University
Selected Publication (2010~) HW Yang MY Hua TL Hwang KJ Lin CY Huang RY Tsai CCM Ma PH Hsu SP Wey PW Hsu PY Chen YC Huang YJ Lu TC Yen LY Feng CW Lin HL Liu KC Wei Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide Advanced Materials Vol 25 No 26 pp3605-3611 2013 HL Liu CH Fan CY Ting and CK Yeh Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors Theranostics Vol 4 No 4 pp432-444 2014 KC Wei PC Chu HYJ Wang CY Huang PY Chen HC Tsai YJ Lu IC Tseng PY Lee TC Yen and HL Liu Focused Ultrasound-induced BloodndashBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment A Preclinical Study PLoS ONE Vol 8 No 3 pp e58995 2013 P-H Hsu K-C Wei C-Y Huang C-J Wen T-C Yen C-L Liu Y-T Lin J-C Chen C-R Shen and H-L Liu Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound PLoS ONE Vol 8 No 2 pp e57682 2013 H-L Liu M-Y Hua H-W Yang C-Y Huang P-C Chu J-S Wua I-C Tseng J-J Wang T-C Yen P-Y Chen and K-C Wei ldquoMagnetic resonance monitoring of focused ultrasoundmagnetic nanoparticle targeting delivery of therapeutic agents to the brainrdquo Proceedings of National Academy of Science USA Vol 107 No 34 pp15205-15210 2010 H-L Liu M-Y Hua P-Y Chen P-C Chu C-H Pan H-W Yang C-Y Huang J-J Wang T-C Yen and K-C Wei ldquoBloodndashBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatmentrdquo Radiology Vol 255 No 2 pp 415-425 2010 H-L Liu Y-Y Wai P-H Hsu L-A Lyu J-S Wu C-R Shen J-C Chen T-C Yen and J-J Wang ldquoIn Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Bloodndashbrain Barrier with Focused Ultrasound A Magnetic Resonance Imaging Studyrdquo Journal of Cerebral Blood Flow amp Metabolism Vol 30 pp 168-177 2010
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
7
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Organizer
Department of Biomedical Engineering and Environmental Sciences (BMES)
National Tsing HuaUniversity (NTHU) Taiwan
清華大學 生醫工程與環境科學系
Department of Materials Science and Technologies
Tokyo University of Science (TUS) Japan
東京理科大學 材料科學與技術系
Co-Organizer
Engineering and Technology Promotion Center
National Science Council (NSC) Taiwan
國家科學委員會 工程科技推展中心
College of Nuclear Science
National Tsing Hua Univeristy (NTHU) Taiwan
清華大學 原子科學院
8
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Map
9
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Program
September 12 (Fri) 2014
Time Agenda Speaker
1900~2100 Welcome and Opening Ceremony (Hall of Fame)
September 13 (Sat) 2014 Place NTHU BMES
Time Agenda Speaker
0830~0900 Registration (Entrance Hall NTHU BMES)
0900~0915 Opening Remarks Symposium Chairs
Session A Biomaterials Moderator Hsin-Cheng Chiu (NTHU) Ryo Ishihara (TUS)
0915~0945 Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes (Keynote)
Prof Yung Chang張
雍
0945~1015 Chemical Modifications for the Developments of Next Generation
Drugs (Keynote)
Prof Yutaka Ikeda
池田豊
1015~1045 Electrospun Composite Nanofibers with Staged Release of Multiple
Angiogenic Growth Factors for Chronic Wound Healing (Keynote)
Prof Tzu-Wei Wang
王子威
1045~1110 Break
1110~1140 Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip
toward Point-of-Care Diagnosis (invited)
Prof Ryo Ishihara石
原量
1140~1210 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and
Imaging Applications (Invited)
Dr Wen-Hsuan
Chiang姜文軒
1200~1330 Lunch
Session B Biomedical Imaging Moderator Chih-Kuang Yeh (NTHU) Kohei Soga (TUS)
1320~1400 Focused-Ultrasound Brain-Drug Delivery Approach and
Application (Keynote)
Prof Hao-Li Liu劉
浩澧
1400~1440 Responsive and Theranostic Nano-Contrast Agents for Preclinical
MR Imaging (Keynote)
Dr Ichio Aoki青木
伊知男
1440~1510 Observation of Single-Molecule Enzymes through Probes under the
Optical Microscope (Keynote)
Prof Tomoko
Masaike政池知子
1510~1630 Break
1630~1710 Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing
SPIO Nanoparticles Ultrasonically (Invited)
Prof Meng-Lin Li
李夢麟
1710~1740 High resolution ultrasound elastography for medical applications
(Invited)
Prof Chih-Chung
Huang黃執中
1740~1810 Biofunctional Polymers for Application of Ceramic Nanoparticles
for Fluorescence Bioimaging (Invited)
Prof Masao
Kamimura上村真生
1900~ Banquet (合口味)
10
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
September 14 (Sun) 2014 Place NTHU BMES
Time Agenda Speaker
0845~0900 Registration
Session C Science and Technology for Environment amp Energy
Moderator Yu-Fen Huang (NTHU) Keishi Nishio (TUS)
0900~0930 Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed
Tungsten Oxide Thin Films for Hydrogen Gas Sensor (Keynote)
Prof Keishi Nishio
西尾圭史
0930~1000 Control of low-concentration gaseous mercury from stationary
sources via adsorption and oxidation (Keynote)
Prof Hsing-Cheng
His席行正
1000~1030 High-Throughput Functional Materials Exploration by
Combinatorial WetDry Process (Keynote)
Prof Kenjiro
Fujimoto藤本憲次
郎
1030~1050 Break
1050~1120 Facile Manufacturing on Energy-efficient Devices with Flexibility
and Antireflection (Invited)
Prof Fu-Hsiang Ko
柯富祥
1120~1150 Proton Distribution and Dynamics in BaZrO3-Based Proton
Conductor for Solid Oxide Fuel Cell (Invited)
Prof Naoto
Kitamura北村尚斗
1150~1220 Harvesting Water Energy by a Sequential Contact-Electrification and
Electrostatic-Induction Process (Invited)
Prof Zong-Hong
Lin林宗宏
1210~1330 Lunch
Poster Session
1330~1530 Poster Session
1600~1800 Move to I-Lan
1800~2000 Luodong Night Market
2000 National Center for Traditional Art I-Lan (宜蘭傳藝)
September 15 (Mon) 2014 Place I-Lan
Time Agenda Speaker
0700~0800 Breakfast
0845~0910 Closing Remarks
(National Center for Traditional Art I-Lan)
0910~1500 Visit National Center for Traditional Art
1150~1330 Lunch
1530 Move to Taipei Railway Station or Hsinchu
11
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker
Invited Speaker A-1 Prof Yung Chang
Distinguished Professor
Department of Chemical Engineering
Deputy Director RampD Center for Membrane Technology
Chung Yuan Christian University
Address Jhong-Li Taoyuan 320 Taiwan
TEL (886) 265-4122
FAX (886) 265-4190
Education 2004 PhD Chemical Engineering National Taiwan University Taiwan 2000 MS Chemical Engineering National Taiwan University Taiwan 1998 BS Chemical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013-present Deputy Director RampD Center for Membrane Technology Chung Yuan Christian
University 2013-present Distinguished Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2013-present Professor Department of Chemical Engineering Chung Yuan Christian University
Taiwan 2009-2013 Associate Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2006-2009 Assistant Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2005-2006 Postdoctoral Fellow Chemical Engineering University of Washington USA 2004-2005 Postdoctoral Fellow Chemical Engineering National Taiwan University Taiwan
Honor and awards (2010~) 2010 Yung Investigator Award of Chemical Engineering (Taiwan Institute of Chemical Engineers) 2010 Yung Investigator Award of Materials on Regenerative Medicine (National Health Research
Institutes Taiwan) 2011 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan) 2011 Outstanding Research Award of Chemical Engineering (LCY Chemical Corp) 2012 NSC Wu Da-Yu Award (National science council Taiwan) 2012 NSC Outstanding AcademicIndustrial Cooperation Award (National science council) 2013 Yung Investigator Award of Polymer Science (Taiwan Institute of Polymer Science) 2013 JCS The Distinguished Lectureship Award Biomaterial Research (Japan Chemical Society) 2013 Ukraine International Invention Exhibition Gold Medal (Ukraine Invention Society) 2014 Pittsburgh International Invention Exhibition Gold Medal (USA Invention Society) 2014 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan)
12
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-1 Sep 13 2014 (Sat) 0915-0945 at NTHU BMES R120
Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes
Chung Yuan
RampD Center for Membrane Technology and Department of Chemical Engineering Christian
University Chung-Li Taoyuan 320 Taiwan
Zwitterionic polymeric interface resisting the adsorption of plasma proteins is important in the
development of blood-contacting biomaterials in such applications as blood collection devices
antithrombogenic implants hemodialysis membranes drug-delivery carriers and diagnostic
biosensors Previous studies showed that the control of surface charge neutrality is important for a
zwitterionic surface with effective protein-resistant properties Importantly it was further reported
that the mixed-charge formulation in self-assembled monolayers copolymer hydrogels and
polymeric brushes provide a new avenue to achieve nonfouling surfaces with the prevention of
nonspecific protein adsorption if the charge balance can be well controlled This talk will cover three
major studies
Bio-inert nature of biomimetic zwitterionicpseudozwitterionic structures
Blood-Inert
Surfaces via ion-pair anchoring of zwitterionic copolymer brushes in human whole blood Surface
zwitterionization of membrenaes in novel biomedical applications
[1] Chang Y Liao SC Higuchi A Ruaan RC Chu CW Chen WY A highly stable nonbiofouling surface with
well-packed grafted zwitterionic polysulfobetaine for plasma protein repulsion Langmuir 2008245453-58
[2] Chiag YC Chang Y Higuchi A Chen WY Ruaan RC Sulfobetaine-grafted poly(vinylidene fluroride) ultrafiltration
membranes exhibit excellent antifouling property Journal of Membrane Science 2009339151-9
[3] Chang Y Yandi W Chen WY Shih YJ Yang CC Chang Y Ling QD Higuchi A Tunable bioadhesive copolymer
hydrogels of thermoresponsive poly(N-isopropyl acrylamide) containing zwitterionic polysulfobetaine
Biomacromolecules 2010111101-10
[4] Chang Y Chang WJ Shih YJ Wei TC Hsiue GH Zwitterionic sulfobetaine-grafted poly(vinylidene fluoride)
membrane with improved blood compatibility via atmospheric plasma-induced surface copolymerization ACS Appl
Mater Interfaces 201131228-37
[5] Shih YJ Chang Y Deratani A Damien Q Schizophrenic hemocompatible copolymers via switchable
thermoresponsive transition of nonioniczwitterionic block self-assembly in human blood Biomacromolecules
2012132849minus58
[6] Chang Y Shih YJ Lai CJ Kung HH Jiang S Ion-pair anchoring of self-assembled zwitterionic copolymer surfaces
with highly controlled blood compatibility Advanced Functional Materials 2013231100-10
13
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-2 Dr Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences
University of Tsukuba
Address Tennoudai 1-1-1 Tsukuba Ibaraki 305-8573 Japan
E-mailikedaimstsukubaacjp
Education March 1999 B S in Faculty of Engineering Kyoto University March 2001 MS in Graduate School of Engineering Department of Synthetic Chemistry and
Biological Chemistry Kyoto University March 2004 PhD in School of Engineering The University of Tokyo
Professional Experience 2004~2006 Advanced industrial science and technology (AIST) 2006~2008 Cytopathfinder Inc 2008~to date University of Tsukuba
Selected Publication (2010~) Y Ikeda J Katamachi H Kawasaki Y Nagasaki Novel protein PEGylation chemistry via glutalaldehydefunctionalized PEG Bioconjugate Chemistry 24 1824-1827 (2013) Y Ikeda D Kubota Y Nagasaki Design of sugar-oligonucleotide conjugates installed gold nanoparticle for effective delivery to hepatic parenchymal cells Colloid and Polymer Science 291 2959-2964 Y Ikeda H Kawasaki S Ichinohe Y Nagasaki Facile solid-phase synthesis of a highly stable poly(ethylene glycol)-oligonucleotide conjugate Journal of Materials Chemistry B 1 529-535(2013) Y Ikeda T Jomura U Horiuchi J Saeki K Yoshimoto T Ikeya Y Nagasaki Long-term survival and functional maintenance of hepatocytes by using a microfabricated cell array Colloid and Surface B Biointerface 97 97-100 2012 Y Ikeda Y Nagasaki PEGylation Technology in Nanomedicine Advances in Polymer Science 247 115-140 2012 Y Ikeda R Suzuki T Yoshitomi Y Nagasaki Novel oligonucleotide carrier possessing reactive oxygen species scavenging ability Macromolecular Bioscience 2011 11 344-351 Y Ikeda D Kubota Y Nagasaki Simple solid-phase synthesis and biological properties of carbohydrate-oligonucleotide conjugates modified at the 3rsquo terminus Bioconjugate Chem 2010 21 1685-1690
14
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-2 Sep 13 2014 (Sat) 0945-1015 at NTHU BMES R120
Chemical Modifications for the Developments of Next Generation Drugs
Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences University of
Tsukuba
Controlling of biodistribution and PKPD is a key issue for the development of drugsVariety of
technologies have been reported to improve those properties Those technologies include
nanoparticle formulation and PEGylation technology In my presentation I will show recent
chemical modification technologies which we developed to improve PKPD and distribution of
drugs
A novel chemistry for the PEGylated protein with a high activity
Several PEGylated proteins have been approved as therapeutic drugs In many cases PEGylated
protein has been synthesized by the conjugation reaction between PEG possessing activated ester and
amine(s) in the protein This reaction however often causes inactivation of PEGylated proteins In
this report we present a novel chemistry which enables the PEGylation of proteins under the mild
reaction condition PEGylated lysozyme prepared by the method developed increased the biological
activity of the PEGylated lysozyme more than 20 times compared with the PEGylated lysozyme
prepared by the conventional method
Design and development of novel hypoxically activated prodrugs
Tumor hypoxia is well known to promote mutagenesis invasiveness and to be associated with a
worse prognosis Although the treatment of the tumor hypoxia has been highly demanded resistance
to radiotherapy and anticancer chemotherapy have been serious problems The object of this study
was the development of hypoxically activated prodrugs which accumulate and act on cells at hypoxic
region of tumor Several conventional anti-cancer drugs including doxorubicin gemcitabine and 5FU
have been modified with 2-nitro imidazole derivative This modification enabled inactivation of drug
to reduce adverse effects under the normoxia condition and selective activation of prodrug under the
hypoxic condition
15
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-3 Prof Tzu-Wei Wang
Associate Professor
Department of Materials Science and Engineering and Institute of Biomedical
Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013
Office Delta Teaching Building R434
TEL +886-3-5715131 ext 33856
Email twwangmxnthuedutw Education 2006 PhD Institute of Biomedical Engineering National Taiwan University Taiwan
Professional Experience 2013 ndashpresent Associate Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2009 -2013 Assistant Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2007-2009 Postdoctoral Research Fellow Tissue Engineering Laboratories of Brigham and Womenrsquos
Hospital Harvard Medical School USA
Honor and awards (2009~) Young Plenary Award 2013 TERMIS-AP Symposium Shanghai China (2013) The 9th National Innovation Award Academic Research Category by Institute for Biotechnology and Medicine Industry Taiwan (2012) Young Investigator Award International Symposium of Materials on Regenerative Medicine Taiwan (2012 ISOMRM) Young Investigator Award 5th World Congress on Bioengineering the World Association for Chinese Biomedical Engineers Taiwan (WACBE 2011)
Selected Publication (2012~) Yang CS Wu HC Sun JS Hsiao HM Wang TW Thermo-induced shape memory PEG-PCL copolymer as dual drug-eluting biodegradable stent ACS Appl Mater Interfaces 2013 5 (21) 10985ndash10994 Yeh PH Sun JS Wu HC Hwang LH Wang TW Stimuli-responsive HA-PEI nanoparticles encapsulating endostatin plasmid for stem cell gene therapy RSC Advances 2013 3 (31) 12922 - 12932 Chen YY Wu HC Sun JS Dong GC Wang TW Injectable and thermoresponsive self-assembled nanocomposite hydrogel for long-term anticancer drug delivery Langmuir 201329(11)3721-3729 Cheng TY Wu HC Chang WH Huang MY Lee CH Wang TW Self-assembling functionalized nanopeptides for immediate hemostasis and accelerative liver tissue regeneration Nanoscale 2013 5 (7) 2734 - 2744 Chang YJ Tsai CJ Tseng FG Chen TJ Wang TW Micropatterned Stretching System for the Investigation of Mechanical Tension on Neural Stem Cells Behavior Nanomedicine Nanotechnology Biology and Medicine 20139345-355 Cheng TY Chen MH Chang WH Huang MY Wang TW Neural stem cells encapsulated in a functionalized self-assembling peptide hydrogel for brain tissue engineering Biomaterials 2013 34(8)2005-2016 Goh JH Wu HC Chen MH Chen MY Chang SC Wang TW Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages Acta Biomaterialia 20139(2)5170-5180 Huang YJ Wu HC Tai NH Wang TW Carbon Nanotube Rope with Electrical Stimulation Promotes the Differentiation and Maturity of Neural Stem Cells Small 20128(18) 2869ndash2877
16
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-3 Sep 13 2014 (Sat) 1015-1045 at NTHU BMES R120
Electrospun Composite Nanofibers with Staged Release of Multiple Angiogenic Growth Factors for Chronic Wound Healing
Tzu-Wei Wang
Department of Materials Science and Engineering and Institute of Biomedical Engineering National
Tsing Hua University
The objective of this research study is to develop collagen (Col) and hyaluronic acid (HA)
inter-stacking nanofibrous skin equivalent substitute with programmable release of multiple
angiogenic growth factors (VEGF PDGF bFGF and EGF) either directly embedded in the
nanofibers or encapsulated in the gelatin nanoparticles (GN) by electrospinning technology The
delivery of EGF and bFGF in early stage is expected to accelerate epithelialization and vasculature
sprouting while release of PDGF and VEGF in late stage is aimed for the induction of blood vessels
maturation The physiochemical characterizations report that the Col-HA-GN nanofibrous membrane
possesses mechanical property similar to human native skin The design of particle-in-fiber structure
allows growth factors for slow controlled release up to one month Cultured on biodegradable
Col-HA membrane with four kinds of growth factors (Col-HA w4GF) endothelial cells not only
increase in growth rate but also form better network of thread-like tubular structure Therapeutic
effect of Col-HA w4GF membrane on STZ-induced diabetic rats reveal accelerated wound closure
rate elevated collagen deposition and enhanced mature vessels by Massonrsquos trichrome stain and
immunohistochemical analysis respectively From the above the electrospun Col-HA-GN composite
nanofibrous skin substitute with stage-wise release pattern of multiple angiogenic factors could be a
promising bioengineered construct for the chronic wound healing in skin tissue regeneration
17
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-4 Assistant Prof Ryo Ishihara
Assistant Professor
Department of Materials Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
Tokyo University of Science Research Building 9th floor
TEL +81-3-5876-1415
FAX +81-3-5876-1415
Education 2012 PhD Department of Applied Chemistry and Biotechnology Chiba University Japan 2008 MS Department of Materials Technology Chiba University Japan 2006 BS Department of Materials Technology Chiba University Japan
Professional Experience 2014 ndashpresent Assistant Professor Department of Materials Science and Technology Tokyo
University of Science 2012 ndash2014 Postdoctral Researcher Bioengineering Laboratory RIKEN
Honor and awards Department chairmanlsquos award from Chiba University (2012)
Selected Publication (2010~) Simple Method for High-Density Impregnation of Aliquat 336 onto Porous Sheet and Binding Performance of Resulting Sheet for Palladium Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota Sep Sci Technol 49154-159 (2014) Effect of Dose on Mole Percentage of Polymer Brush and Root Grafted onto Porous Polyethylene Sheet by Radiation-Induced Graft Polymerization R Ishihara S Uchiyama H Ikezawa S Yamada H Hirota D Umeno K Saito Ind Eng Chem Res 5212582-12586 (2013) Determination of Mole Percentages of Brush and Root of Polymer Chain Grafted onto Porous Sheet S Uchiyama R Ishihara D Umeno K Saito S Yamada H Hirota S Asai J Chem Eng Japan 46414-419 (2013) Crosslinked-chelating Porous Sheet with High Dynamic Binding Capacity of Metal Ions G Wada R Ishihara K Miyoshi D Umeno K Saito S Yamada H Hirota Solv Extr Ion Exch 31210-220 (2013) Dependence of Lanthanide-Ion Binding Performance on HDEHP Concentration in HDEHP Impregnation to Porous Sheet R Ishihara S Asai S Otosaka S Yamada H Hirota K Miyoshi D Umeno K Saito Solv Extr Ion Exch 30171-180 (2012) Impregnation of TOPO onto Hydrophobic-Ligand-Containing Porous Sheet and Its Adsorptionelution Performance of Bismuth Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota React Funct Polym 70986-990 (2010)
18
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-4 Sep 13 2014 (Sat) 1110-1140 at NTHU BMES R120
Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip toward Point-of-Care Diagnosis
Ryo Ishihara Kazuo Hosokawa Mizuo Maeda
Bioengineering Laboratory RIKEN
MicroRNAs (miRNAs) are short and non-protein-coding single-stranded RNAs and have shown great promise for
cancer diagnosis Some miRNAs circulate in human body fluid with extremely low concentrations and its expression
profiling can detect and classify cancers in the human body [1] Point-of-care (POC) diagnosis requires short detection
time small required sample volume and portability of the device In various miRNA detection methods microfluidic
chip meets the requirements except the portability Hence we used our power-free pump-free microfluidic chip driven
by energy that is stored in degased PDMS to overcome those drawbacks which eliminates the need for external power
sources for fluid pumping [2] The pump-free pumping method is essential for microfluidic chip-based POC diagnosis In
our laboratory rapid and sensitive singleplex miRNA detection with laminar flow-assisted dendritic amplification (LFDA)
[3] on the pump-free microfluidic chip has been developed [4] In this study rapid and sensitive multiplex miRNA
detection on the pump-free microfluidic chip was demonstrated
Pump-free microchip for multiplex miRNA detection was prepared as follows First the PDMS part with a pair of
Y-shaped microchannels with 100 μm in width and 25 μm in height was fabricated Second three parallel-line-shaped
probe DNAs were patterned onto a glass surface Third the PDMS channels were attached onto the glass plate Finally
the chip was degassed in a vacuum chamber After the chip preparation target miRNAs were detected following three
steps (1) blocking (2) sandwich hybridization of the target miRNAs and biotinylated probe DNAs and (3) signal
amplification by LFDA MiR-16 miR-21-5p and miR-500a-3p were used as target miRNAs since they are known as
cancer biomarkers [5-7] Fluorescence signals were captured by CCD camera and analyzed by the software (ImageJ)
Bright lines appeared at the expected positions they appeared only on the areas with the respective probe DNA in which
the target miRNAs had been supplied These data prove that the LFDA successfully took place in a target
sequence-dependent manner Calibration curves were plotted from the fluorescence signals The data points of the
calibration curve were fitted with the four-parameter logistic function and limit-of-detections (LODs) were evaluated by
the 3σ criterion LODs of the miR-16 miR-21-5p and miR-500a-3p were 68 fM 15 pM and 150 fM respectively The
LODs are on the same order of magnitude as concentrations of miRNA in blood Multiplex detection was verified from
correspondence between the calibration curves of single and multiplex The required sample volume was 05 microL and
assay time was 20 min Because most of the existing methods take more than a few hours the rapidness small required
sample volume and portability of the device are ideal advantages for POC diagnosis
References
[1] PS Mitchell et al PNAS 105 (2008) 10513 [2] K Hosokawa et al Lab Chip 4 (2004) 181 [3] K Hosokawa et al Anal
Chem 79 (2007) 6000 [4] H Arata et al PLoS ONE 7 (2012) e48329 [5] MJ Lodes et al PLoS ONE 4 (2009) e6229
[6] Y Toiyama et al J Natl Cancer Inst 105 (2013) 849 [7] Y Yamamoto et al Biomarkers 14 (2009) 529
19
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-5 Dr Wen-Hsuan Chiang
Assistant Researcher
Department of Biomedical Engineering and Environmental Sciences
National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
TEL (886) 3-571-5131 ext 35576
Education 2009 PhD Department of Chemical Engineering National Chung Hsing University Taiwan Thesis Supervisor Professor Hsin-Cheng Chiu 2002 BS Department of Chemical Engineering Tatung University Taiwan Professional Experience 2013 ndashpresent Assistant Researcher Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University 2010 ndash2012 Postdoctoral Fellow Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
Areas of Research Expertise Biomaterials Smart Amphiphilic Copolymers Multifunctional Nanocarriers for Cancer Therapy and Imaging Nano Science and Interfacial Engineering
Selected Publication (2010~) Wen-Hsuan Chiang Wen-Chia Huang Ming-Yin Shen Che-Hsu Wang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Dual-Layered Nanogel-Coated Hollow LipidPolypeptide Conjugate Assemblies for Potential pH-Triggered Intracellular Drug Release PLOS ONE 2014 9 1-11 Wen-Hsuan Chiang Wen-Chia Huang Chien-Wen Chang Ming-Yin Shen Zong-Fu Shih Yi-Fong Huang Sung-Chyr Lin Hsin-Cheng Chiu Functionalized Polymersomes with Outlayered Polyelectrolyte Gels for Potential Tumor-Targeted Delivery of Multimodal Therapies and MR Imaging Journal of Controlled Release 2013 168 280-288 Wen-Hsuan Chiang Viet Thang Ho Hsin-Hung Chen Wen-Chia Huang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Superparamagnetic Hollow Hybrid Nanogels as a Potential Guidable Vehicle System of Stimuli-Mediated MR Imaging and Multiple Cancer Therapeutics Langmuir 2013 29 6434-6443 Wen-Hsuan Chiang Viet Thang Ho Wen-Chia Huang Yi-Fong Huang Chorng-Shyan Chern Hsin-Cheng Chiu Dual Stimuli-Responsive Polymeric Hollow Nanogels Designed as Carriers for Intracellular Triggered Drug Release Langmuir 2012 28 15056-15064 Yi-Fong HuangDagger Wen-Hsuan ChiangDagger Pei-Ling Tsai Chorng-Shyan Chern Hsin-Cheng Chiu Novel Hybrid Vesicles Co-Assembled from Cationic Lipid and PAAc-g-mPEG with pH-Triggered Transmembrane Channels for Controlled Drug Release Chemical Communications 2011 47 10978-10980
20
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-5 Sep 13 2014 (Sat) 1140-1210 at NTHU BMES R120 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and Imaging
Applications
Wen-Hsuan Chiang
Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
In order to promote therapeutic efficacy and minimize side effect equipping these nanocarriers with the
capability of controlling drug release in response to an appropriate stimulus is essentially required Acidic pH
as an internal stimulus is particular appealing because of the mildly acid pH encountered in tumor tissues and
the intracellular compartments such as endosomes and lysosomes Therefore the pH-responsive drug carriers
have been extensively developed for improving intracellular drug delivery To realize the pH-responsive drug
release we adopted a simple approach to design the lipidPEG-containing complex vesicles with pH-triggered
transmembrane channels as a chemotherapy drug doxorubicin (DOX) delivery carrier In this study the
complex vesicles were attained by spontaneous co-assembly of poly(acrylic acid)-g-poly(monomethoxy
ethylene glycol) (PAAc-g-mPEG) with a cationic lipid didodecyldimethylammonium bromide (DDAB) in
aqueous phase of pH 89 via electrostatic interactions Through the formation of unionized AAc-rich
transmembrance channels of complex vesicles in weak acidic environments the acid-triggered rapid drug
release can be achieved
On the other hand for simultaneously monitoring disease progression and biological response after
treatments we developed a novel tumor-targeting polymersome system capable of delivering magnetic
resonance imaging (MRI) and chemotherapy The DOX-loaded magnetic polymersomes were first attained by
the self-assembly of lipid-containing copolymer poly(AAc-co-distearin acrylate) in aqueous solution
containing citric acid-coated superparamagnetic iron oxide nanoparticles (SPIONs) and followed by DOX
loading via electrostatic attraction To further functionalize these vesicles with superior in vivo colloidal
stability pH-tunable drug release and active tumor-targeting chitosan and poly( -glutamic
acid-co- -glutamyl oxysuccinimide)-g-PEG-folate (FA) were deposited in sequence onto the assembly outer
surfaces The interfacial nanogel layers via electrostatic interactions and in-situ covalent cross-linking were
thus produced Triggerable release of the encapsulated DOX was governed by dual external stimuli pH and
temperature When these theranostic NCPs were effectively internalized by HeLa cells via FA
receptor-mediated endocytosis and then exposed to high frequency magnetic fields (HFMF) the combined
effects of both pH and magnetic hyperthermia-triggered drug release and thermo-therapy resulted in greater
cytotoxicity than the treatment by DOX alone By virtue of the SPION clustering effect in the assembly inner
aqueous compartments the SPIONDOX-loaded NCPs displayed an r2 relaxivity value higher than Resovist
a commercial SPION-based T2 contrast agent The high magnetic relaxivity of the tumor-targeting NCPs
coupled with their enhanced cellular uptake considerably promoted the MRI contrast of targeted cancer cells
These results demonstrate the great potential of the FA-decorated SPIONDOX-loaded NCPs as an advanced
cancer theranostic nanodevice
21
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-1 Prof Hao-Li Liu Professor and Director
Department of Electrical Engineering
Chang Gung University
Phone +886-3-2118800 ext 5677
Fax +886-3-2118026
E-mail haoliliumailcguedutw
Education 2003 PhD National Taiwan University Taipei TAIWAN 1998 M S National Taiwan University Taipei TAIWAN 1996 B S National Taipei University of Technology TAIWAN
Professional Experience 2012-present Director Dept of Electrical Engineering Chang Gung Univ Taiwan 2011-present Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2008 Associate Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2005 ndash2008 Assistant Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2004 ndash2005 Research Fellow Department of Radiology Brigham amp Womenrsquos Hospital Harvard Medical School MA USA
Honor and awards (2009~) 2013 Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) 2013 The 2013 Frederick Lizzi Award International Society of Therapeutic Ultrasound 2011 Distinguished Tech-Coop Award (長庚大學優良教師技合獎) Chang-Gung University 2011 Wu Ta-You Memorial Award (吳大猷先生紀念獎) National Science Council Taiwan 2011 2010 Distinguished Research Award (長庚大學優良教師研究獎) Chang-Gung University
Selected Publication (2010~) HW Yang MY Hua TL Hwang KJ Lin CY Huang RY Tsai CCM Ma PH Hsu SP Wey PW Hsu PY Chen YC Huang YJ Lu TC Yen LY Feng CW Lin HL Liu KC Wei Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide Advanced Materials Vol 25 No 26 pp3605-3611 2013 HL Liu CH Fan CY Ting and CK Yeh Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors Theranostics Vol 4 No 4 pp432-444 2014 KC Wei PC Chu HYJ Wang CY Huang PY Chen HC Tsai YJ Lu IC Tseng PY Lee TC Yen and HL Liu Focused Ultrasound-induced BloodndashBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment A Preclinical Study PLoS ONE Vol 8 No 3 pp e58995 2013 P-H Hsu K-C Wei C-Y Huang C-J Wen T-C Yen C-L Liu Y-T Lin J-C Chen C-R Shen and H-L Liu Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound PLoS ONE Vol 8 No 2 pp e57682 2013 H-L Liu M-Y Hua H-W Yang C-Y Huang P-C Chu J-S Wua I-C Tseng J-J Wang T-C Yen P-Y Chen and K-C Wei ldquoMagnetic resonance monitoring of focused ultrasoundmagnetic nanoparticle targeting delivery of therapeutic agents to the brainrdquo Proceedings of National Academy of Science USA Vol 107 No 34 pp15205-15210 2010 H-L Liu M-Y Hua P-Y Chen P-C Chu C-H Pan H-W Yang C-Y Huang J-J Wang T-C Yen and K-C Wei ldquoBloodndashBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatmentrdquo Radiology Vol 255 No 2 pp 415-425 2010 H-L Liu Y-Y Wai P-H Hsu L-A Lyu J-S Wu C-R Shen J-C Chen T-C Yen and J-J Wang ldquoIn Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Bloodndashbrain Barrier with Focused Ultrasound A Magnetic Resonance Imaging Studyrdquo Journal of Cerebral Blood Flow amp Metabolism Vol 30 pp 168-177 2010
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
8
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Map
9
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Program
September 12 (Fri) 2014
Time Agenda Speaker
1900~2100 Welcome and Opening Ceremony (Hall of Fame)
September 13 (Sat) 2014 Place NTHU BMES
Time Agenda Speaker
0830~0900 Registration (Entrance Hall NTHU BMES)
0900~0915 Opening Remarks Symposium Chairs
Session A Biomaterials Moderator Hsin-Cheng Chiu (NTHU) Ryo Ishihara (TUS)
0915~0945 Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes (Keynote)
Prof Yung Chang張
雍
0945~1015 Chemical Modifications for the Developments of Next Generation
Drugs (Keynote)
Prof Yutaka Ikeda
池田豊
1015~1045 Electrospun Composite Nanofibers with Staged Release of Multiple
Angiogenic Growth Factors for Chronic Wound Healing (Keynote)
Prof Tzu-Wei Wang
王子威
1045~1110 Break
1110~1140 Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip
toward Point-of-Care Diagnosis (invited)
Prof Ryo Ishihara石
原量
1140~1210 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and
Imaging Applications (Invited)
Dr Wen-Hsuan
Chiang姜文軒
1200~1330 Lunch
Session B Biomedical Imaging Moderator Chih-Kuang Yeh (NTHU) Kohei Soga (TUS)
1320~1400 Focused-Ultrasound Brain-Drug Delivery Approach and
Application (Keynote)
Prof Hao-Li Liu劉
浩澧
1400~1440 Responsive and Theranostic Nano-Contrast Agents for Preclinical
MR Imaging (Keynote)
Dr Ichio Aoki青木
伊知男
1440~1510 Observation of Single-Molecule Enzymes through Probes under the
Optical Microscope (Keynote)
Prof Tomoko
Masaike政池知子
1510~1630 Break
1630~1710 Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing
SPIO Nanoparticles Ultrasonically (Invited)
Prof Meng-Lin Li
李夢麟
1710~1740 High resolution ultrasound elastography for medical applications
(Invited)
Prof Chih-Chung
Huang黃執中
1740~1810 Biofunctional Polymers for Application of Ceramic Nanoparticles
for Fluorescence Bioimaging (Invited)
Prof Masao
Kamimura上村真生
1900~ Banquet (合口味)
10
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
September 14 (Sun) 2014 Place NTHU BMES
Time Agenda Speaker
0845~0900 Registration
Session C Science and Technology for Environment amp Energy
Moderator Yu-Fen Huang (NTHU) Keishi Nishio (TUS)
0900~0930 Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed
Tungsten Oxide Thin Films for Hydrogen Gas Sensor (Keynote)
Prof Keishi Nishio
西尾圭史
0930~1000 Control of low-concentration gaseous mercury from stationary
sources via adsorption and oxidation (Keynote)
Prof Hsing-Cheng
His席行正
1000~1030 High-Throughput Functional Materials Exploration by
Combinatorial WetDry Process (Keynote)
Prof Kenjiro
Fujimoto藤本憲次
郎
1030~1050 Break
1050~1120 Facile Manufacturing on Energy-efficient Devices with Flexibility
and Antireflection (Invited)
Prof Fu-Hsiang Ko
柯富祥
1120~1150 Proton Distribution and Dynamics in BaZrO3-Based Proton
Conductor for Solid Oxide Fuel Cell (Invited)
Prof Naoto
Kitamura北村尚斗
1150~1220 Harvesting Water Energy by a Sequential Contact-Electrification and
Electrostatic-Induction Process (Invited)
Prof Zong-Hong
Lin林宗宏
1210~1330 Lunch
Poster Session
1330~1530 Poster Session
1600~1800 Move to I-Lan
1800~2000 Luodong Night Market
2000 National Center for Traditional Art I-Lan (宜蘭傳藝)
September 15 (Mon) 2014 Place I-Lan
Time Agenda Speaker
0700~0800 Breakfast
0845~0910 Closing Remarks
(National Center for Traditional Art I-Lan)
0910~1500 Visit National Center for Traditional Art
1150~1330 Lunch
1530 Move to Taipei Railway Station or Hsinchu
11
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker
Invited Speaker A-1 Prof Yung Chang
Distinguished Professor
Department of Chemical Engineering
Deputy Director RampD Center for Membrane Technology
Chung Yuan Christian University
Address Jhong-Li Taoyuan 320 Taiwan
TEL (886) 265-4122
FAX (886) 265-4190
Education 2004 PhD Chemical Engineering National Taiwan University Taiwan 2000 MS Chemical Engineering National Taiwan University Taiwan 1998 BS Chemical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013-present Deputy Director RampD Center for Membrane Technology Chung Yuan Christian
University 2013-present Distinguished Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2013-present Professor Department of Chemical Engineering Chung Yuan Christian University
Taiwan 2009-2013 Associate Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2006-2009 Assistant Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2005-2006 Postdoctoral Fellow Chemical Engineering University of Washington USA 2004-2005 Postdoctoral Fellow Chemical Engineering National Taiwan University Taiwan
Honor and awards (2010~) 2010 Yung Investigator Award of Chemical Engineering (Taiwan Institute of Chemical Engineers) 2010 Yung Investigator Award of Materials on Regenerative Medicine (National Health Research
Institutes Taiwan) 2011 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan) 2011 Outstanding Research Award of Chemical Engineering (LCY Chemical Corp) 2012 NSC Wu Da-Yu Award (National science council Taiwan) 2012 NSC Outstanding AcademicIndustrial Cooperation Award (National science council) 2013 Yung Investigator Award of Polymer Science (Taiwan Institute of Polymer Science) 2013 JCS The Distinguished Lectureship Award Biomaterial Research (Japan Chemical Society) 2013 Ukraine International Invention Exhibition Gold Medal (Ukraine Invention Society) 2014 Pittsburgh International Invention Exhibition Gold Medal (USA Invention Society) 2014 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan)
12
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-1 Sep 13 2014 (Sat) 0915-0945 at NTHU BMES R120
Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes
Chung Yuan
RampD Center for Membrane Technology and Department of Chemical Engineering Christian
University Chung-Li Taoyuan 320 Taiwan
Zwitterionic polymeric interface resisting the adsorption of plasma proteins is important in the
development of blood-contacting biomaterials in such applications as blood collection devices
antithrombogenic implants hemodialysis membranes drug-delivery carriers and diagnostic
biosensors Previous studies showed that the control of surface charge neutrality is important for a
zwitterionic surface with effective protein-resistant properties Importantly it was further reported
that the mixed-charge formulation in self-assembled monolayers copolymer hydrogels and
polymeric brushes provide a new avenue to achieve nonfouling surfaces with the prevention of
nonspecific protein adsorption if the charge balance can be well controlled This talk will cover three
major studies
Bio-inert nature of biomimetic zwitterionicpseudozwitterionic structures
Blood-Inert
Surfaces via ion-pair anchoring of zwitterionic copolymer brushes in human whole blood Surface
zwitterionization of membrenaes in novel biomedical applications
[1] Chang Y Liao SC Higuchi A Ruaan RC Chu CW Chen WY A highly stable nonbiofouling surface with
well-packed grafted zwitterionic polysulfobetaine for plasma protein repulsion Langmuir 2008245453-58
[2] Chiag YC Chang Y Higuchi A Chen WY Ruaan RC Sulfobetaine-grafted poly(vinylidene fluroride) ultrafiltration
membranes exhibit excellent antifouling property Journal of Membrane Science 2009339151-9
[3] Chang Y Yandi W Chen WY Shih YJ Yang CC Chang Y Ling QD Higuchi A Tunable bioadhesive copolymer
hydrogels of thermoresponsive poly(N-isopropyl acrylamide) containing zwitterionic polysulfobetaine
Biomacromolecules 2010111101-10
[4] Chang Y Chang WJ Shih YJ Wei TC Hsiue GH Zwitterionic sulfobetaine-grafted poly(vinylidene fluoride)
membrane with improved blood compatibility via atmospheric plasma-induced surface copolymerization ACS Appl
Mater Interfaces 201131228-37
[5] Shih YJ Chang Y Deratani A Damien Q Schizophrenic hemocompatible copolymers via switchable
thermoresponsive transition of nonioniczwitterionic block self-assembly in human blood Biomacromolecules
2012132849minus58
[6] Chang Y Shih YJ Lai CJ Kung HH Jiang S Ion-pair anchoring of self-assembled zwitterionic copolymer surfaces
with highly controlled blood compatibility Advanced Functional Materials 2013231100-10
13
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-2 Dr Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences
University of Tsukuba
Address Tennoudai 1-1-1 Tsukuba Ibaraki 305-8573 Japan
E-mailikedaimstsukubaacjp
Education March 1999 B S in Faculty of Engineering Kyoto University March 2001 MS in Graduate School of Engineering Department of Synthetic Chemistry and
Biological Chemistry Kyoto University March 2004 PhD in School of Engineering The University of Tokyo
Professional Experience 2004~2006 Advanced industrial science and technology (AIST) 2006~2008 Cytopathfinder Inc 2008~to date University of Tsukuba
Selected Publication (2010~) Y Ikeda J Katamachi H Kawasaki Y Nagasaki Novel protein PEGylation chemistry via glutalaldehydefunctionalized PEG Bioconjugate Chemistry 24 1824-1827 (2013) Y Ikeda D Kubota Y Nagasaki Design of sugar-oligonucleotide conjugates installed gold nanoparticle for effective delivery to hepatic parenchymal cells Colloid and Polymer Science 291 2959-2964 Y Ikeda H Kawasaki S Ichinohe Y Nagasaki Facile solid-phase synthesis of a highly stable poly(ethylene glycol)-oligonucleotide conjugate Journal of Materials Chemistry B 1 529-535(2013) Y Ikeda T Jomura U Horiuchi J Saeki K Yoshimoto T Ikeya Y Nagasaki Long-term survival and functional maintenance of hepatocytes by using a microfabricated cell array Colloid and Surface B Biointerface 97 97-100 2012 Y Ikeda Y Nagasaki PEGylation Technology in Nanomedicine Advances in Polymer Science 247 115-140 2012 Y Ikeda R Suzuki T Yoshitomi Y Nagasaki Novel oligonucleotide carrier possessing reactive oxygen species scavenging ability Macromolecular Bioscience 2011 11 344-351 Y Ikeda D Kubota Y Nagasaki Simple solid-phase synthesis and biological properties of carbohydrate-oligonucleotide conjugates modified at the 3rsquo terminus Bioconjugate Chem 2010 21 1685-1690
14
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-2 Sep 13 2014 (Sat) 0945-1015 at NTHU BMES R120
Chemical Modifications for the Developments of Next Generation Drugs
Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences University of
Tsukuba
Controlling of biodistribution and PKPD is a key issue for the development of drugsVariety of
technologies have been reported to improve those properties Those technologies include
nanoparticle formulation and PEGylation technology In my presentation I will show recent
chemical modification technologies which we developed to improve PKPD and distribution of
drugs
A novel chemistry for the PEGylated protein with a high activity
Several PEGylated proteins have been approved as therapeutic drugs In many cases PEGylated
protein has been synthesized by the conjugation reaction between PEG possessing activated ester and
amine(s) in the protein This reaction however often causes inactivation of PEGylated proteins In
this report we present a novel chemistry which enables the PEGylation of proteins under the mild
reaction condition PEGylated lysozyme prepared by the method developed increased the biological
activity of the PEGylated lysozyme more than 20 times compared with the PEGylated lysozyme
prepared by the conventional method
Design and development of novel hypoxically activated prodrugs
Tumor hypoxia is well known to promote mutagenesis invasiveness and to be associated with a
worse prognosis Although the treatment of the tumor hypoxia has been highly demanded resistance
to radiotherapy and anticancer chemotherapy have been serious problems The object of this study
was the development of hypoxically activated prodrugs which accumulate and act on cells at hypoxic
region of tumor Several conventional anti-cancer drugs including doxorubicin gemcitabine and 5FU
have been modified with 2-nitro imidazole derivative This modification enabled inactivation of drug
to reduce adverse effects under the normoxia condition and selective activation of prodrug under the
hypoxic condition
15
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-3 Prof Tzu-Wei Wang
Associate Professor
Department of Materials Science and Engineering and Institute of Biomedical
Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013
Office Delta Teaching Building R434
TEL +886-3-5715131 ext 33856
Email twwangmxnthuedutw Education 2006 PhD Institute of Biomedical Engineering National Taiwan University Taiwan
Professional Experience 2013 ndashpresent Associate Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2009 -2013 Assistant Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2007-2009 Postdoctoral Research Fellow Tissue Engineering Laboratories of Brigham and Womenrsquos
Hospital Harvard Medical School USA
Honor and awards (2009~) Young Plenary Award 2013 TERMIS-AP Symposium Shanghai China (2013) The 9th National Innovation Award Academic Research Category by Institute for Biotechnology and Medicine Industry Taiwan (2012) Young Investigator Award International Symposium of Materials on Regenerative Medicine Taiwan (2012 ISOMRM) Young Investigator Award 5th World Congress on Bioengineering the World Association for Chinese Biomedical Engineers Taiwan (WACBE 2011)
Selected Publication (2012~) Yang CS Wu HC Sun JS Hsiao HM Wang TW Thermo-induced shape memory PEG-PCL copolymer as dual drug-eluting biodegradable stent ACS Appl Mater Interfaces 2013 5 (21) 10985ndash10994 Yeh PH Sun JS Wu HC Hwang LH Wang TW Stimuli-responsive HA-PEI nanoparticles encapsulating endostatin plasmid for stem cell gene therapy RSC Advances 2013 3 (31) 12922 - 12932 Chen YY Wu HC Sun JS Dong GC Wang TW Injectable and thermoresponsive self-assembled nanocomposite hydrogel for long-term anticancer drug delivery Langmuir 201329(11)3721-3729 Cheng TY Wu HC Chang WH Huang MY Lee CH Wang TW Self-assembling functionalized nanopeptides for immediate hemostasis and accelerative liver tissue regeneration Nanoscale 2013 5 (7) 2734 - 2744 Chang YJ Tsai CJ Tseng FG Chen TJ Wang TW Micropatterned Stretching System for the Investigation of Mechanical Tension on Neural Stem Cells Behavior Nanomedicine Nanotechnology Biology and Medicine 20139345-355 Cheng TY Chen MH Chang WH Huang MY Wang TW Neural stem cells encapsulated in a functionalized self-assembling peptide hydrogel for brain tissue engineering Biomaterials 2013 34(8)2005-2016 Goh JH Wu HC Chen MH Chen MY Chang SC Wang TW Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages Acta Biomaterialia 20139(2)5170-5180 Huang YJ Wu HC Tai NH Wang TW Carbon Nanotube Rope with Electrical Stimulation Promotes the Differentiation and Maturity of Neural Stem Cells Small 20128(18) 2869ndash2877
16
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-3 Sep 13 2014 (Sat) 1015-1045 at NTHU BMES R120
Electrospun Composite Nanofibers with Staged Release of Multiple Angiogenic Growth Factors for Chronic Wound Healing
Tzu-Wei Wang
Department of Materials Science and Engineering and Institute of Biomedical Engineering National
Tsing Hua University
The objective of this research study is to develop collagen (Col) and hyaluronic acid (HA)
inter-stacking nanofibrous skin equivalent substitute with programmable release of multiple
angiogenic growth factors (VEGF PDGF bFGF and EGF) either directly embedded in the
nanofibers or encapsulated in the gelatin nanoparticles (GN) by electrospinning technology The
delivery of EGF and bFGF in early stage is expected to accelerate epithelialization and vasculature
sprouting while release of PDGF and VEGF in late stage is aimed for the induction of blood vessels
maturation The physiochemical characterizations report that the Col-HA-GN nanofibrous membrane
possesses mechanical property similar to human native skin The design of particle-in-fiber structure
allows growth factors for slow controlled release up to one month Cultured on biodegradable
Col-HA membrane with four kinds of growth factors (Col-HA w4GF) endothelial cells not only
increase in growth rate but also form better network of thread-like tubular structure Therapeutic
effect of Col-HA w4GF membrane on STZ-induced diabetic rats reveal accelerated wound closure
rate elevated collagen deposition and enhanced mature vessels by Massonrsquos trichrome stain and
immunohistochemical analysis respectively From the above the electrospun Col-HA-GN composite
nanofibrous skin substitute with stage-wise release pattern of multiple angiogenic factors could be a
promising bioengineered construct for the chronic wound healing in skin tissue regeneration
17
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-4 Assistant Prof Ryo Ishihara
Assistant Professor
Department of Materials Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
Tokyo University of Science Research Building 9th floor
TEL +81-3-5876-1415
FAX +81-3-5876-1415
Education 2012 PhD Department of Applied Chemistry and Biotechnology Chiba University Japan 2008 MS Department of Materials Technology Chiba University Japan 2006 BS Department of Materials Technology Chiba University Japan
Professional Experience 2014 ndashpresent Assistant Professor Department of Materials Science and Technology Tokyo
University of Science 2012 ndash2014 Postdoctral Researcher Bioengineering Laboratory RIKEN
Honor and awards Department chairmanlsquos award from Chiba University (2012)
Selected Publication (2010~) Simple Method for High-Density Impregnation of Aliquat 336 onto Porous Sheet and Binding Performance of Resulting Sheet for Palladium Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota Sep Sci Technol 49154-159 (2014) Effect of Dose on Mole Percentage of Polymer Brush and Root Grafted onto Porous Polyethylene Sheet by Radiation-Induced Graft Polymerization R Ishihara S Uchiyama H Ikezawa S Yamada H Hirota D Umeno K Saito Ind Eng Chem Res 5212582-12586 (2013) Determination of Mole Percentages of Brush and Root of Polymer Chain Grafted onto Porous Sheet S Uchiyama R Ishihara D Umeno K Saito S Yamada H Hirota S Asai J Chem Eng Japan 46414-419 (2013) Crosslinked-chelating Porous Sheet with High Dynamic Binding Capacity of Metal Ions G Wada R Ishihara K Miyoshi D Umeno K Saito S Yamada H Hirota Solv Extr Ion Exch 31210-220 (2013) Dependence of Lanthanide-Ion Binding Performance on HDEHP Concentration in HDEHP Impregnation to Porous Sheet R Ishihara S Asai S Otosaka S Yamada H Hirota K Miyoshi D Umeno K Saito Solv Extr Ion Exch 30171-180 (2012) Impregnation of TOPO onto Hydrophobic-Ligand-Containing Porous Sheet and Its Adsorptionelution Performance of Bismuth Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota React Funct Polym 70986-990 (2010)
18
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-4 Sep 13 2014 (Sat) 1110-1140 at NTHU BMES R120
Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip toward Point-of-Care Diagnosis
Ryo Ishihara Kazuo Hosokawa Mizuo Maeda
Bioengineering Laboratory RIKEN
MicroRNAs (miRNAs) are short and non-protein-coding single-stranded RNAs and have shown great promise for
cancer diagnosis Some miRNAs circulate in human body fluid with extremely low concentrations and its expression
profiling can detect and classify cancers in the human body [1] Point-of-care (POC) diagnosis requires short detection
time small required sample volume and portability of the device In various miRNA detection methods microfluidic
chip meets the requirements except the portability Hence we used our power-free pump-free microfluidic chip driven
by energy that is stored in degased PDMS to overcome those drawbacks which eliminates the need for external power
sources for fluid pumping [2] The pump-free pumping method is essential for microfluidic chip-based POC diagnosis In
our laboratory rapid and sensitive singleplex miRNA detection with laminar flow-assisted dendritic amplification (LFDA)
[3] on the pump-free microfluidic chip has been developed [4] In this study rapid and sensitive multiplex miRNA
detection on the pump-free microfluidic chip was demonstrated
Pump-free microchip for multiplex miRNA detection was prepared as follows First the PDMS part with a pair of
Y-shaped microchannels with 100 μm in width and 25 μm in height was fabricated Second three parallel-line-shaped
probe DNAs were patterned onto a glass surface Third the PDMS channels were attached onto the glass plate Finally
the chip was degassed in a vacuum chamber After the chip preparation target miRNAs were detected following three
steps (1) blocking (2) sandwich hybridization of the target miRNAs and biotinylated probe DNAs and (3) signal
amplification by LFDA MiR-16 miR-21-5p and miR-500a-3p were used as target miRNAs since they are known as
cancer biomarkers [5-7] Fluorescence signals were captured by CCD camera and analyzed by the software (ImageJ)
Bright lines appeared at the expected positions they appeared only on the areas with the respective probe DNA in which
the target miRNAs had been supplied These data prove that the LFDA successfully took place in a target
sequence-dependent manner Calibration curves were plotted from the fluorescence signals The data points of the
calibration curve were fitted with the four-parameter logistic function and limit-of-detections (LODs) were evaluated by
the 3σ criterion LODs of the miR-16 miR-21-5p and miR-500a-3p were 68 fM 15 pM and 150 fM respectively The
LODs are on the same order of magnitude as concentrations of miRNA in blood Multiplex detection was verified from
correspondence between the calibration curves of single and multiplex The required sample volume was 05 microL and
assay time was 20 min Because most of the existing methods take more than a few hours the rapidness small required
sample volume and portability of the device are ideal advantages for POC diagnosis
References
[1] PS Mitchell et al PNAS 105 (2008) 10513 [2] K Hosokawa et al Lab Chip 4 (2004) 181 [3] K Hosokawa et al Anal
Chem 79 (2007) 6000 [4] H Arata et al PLoS ONE 7 (2012) e48329 [5] MJ Lodes et al PLoS ONE 4 (2009) e6229
[6] Y Toiyama et al J Natl Cancer Inst 105 (2013) 849 [7] Y Yamamoto et al Biomarkers 14 (2009) 529
19
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-5 Dr Wen-Hsuan Chiang
Assistant Researcher
Department of Biomedical Engineering and Environmental Sciences
National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
TEL (886) 3-571-5131 ext 35576
Education 2009 PhD Department of Chemical Engineering National Chung Hsing University Taiwan Thesis Supervisor Professor Hsin-Cheng Chiu 2002 BS Department of Chemical Engineering Tatung University Taiwan Professional Experience 2013 ndashpresent Assistant Researcher Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University 2010 ndash2012 Postdoctoral Fellow Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
Areas of Research Expertise Biomaterials Smart Amphiphilic Copolymers Multifunctional Nanocarriers for Cancer Therapy and Imaging Nano Science and Interfacial Engineering
Selected Publication (2010~) Wen-Hsuan Chiang Wen-Chia Huang Ming-Yin Shen Che-Hsu Wang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Dual-Layered Nanogel-Coated Hollow LipidPolypeptide Conjugate Assemblies for Potential pH-Triggered Intracellular Drug Release PLOS ONE 2014 9 1-11 Wen-Hsuan Chiang Wen-Chia Huang Chien-Wen Chang Ming-Yin Shen Zong-Fu Shih Yi-Fong Huang Sung-Chyr Lin Hsin-Cheng Chiu Functionalized Polymersomes with Outlayered Polyelectrolyte Gels for Potential Tumor-Targeted Delivery of Multimodal Therapies and MR Imaging Journal of Controlled Release 2013 168 280-288 Wen-Hsuan Chiang Viet Thang Ho Hsin-Hung Chen Wen-Chia Huang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Superparamagnetic Hollow Hybrid Nanogels as a Potential Guidable Vehicle System of Stimuli-Mediated MR Imaging and Multiple Cancer Therapeutics Langmuir 2013 29 6434-6443 Wen-Hsuan Chiang Viet Thang Ho Wen-Chia Huang Yi-Fong Huang Chorng-Shyan Chern Hsin-Cheng Chiu Dual Stimuli-Responsive Polymeric Hollow Nanogels Designed as Carriers for Intracellular Triggered Drug Release Langmuir 2012 28 15056-15064 Yi-Fong HuangDagger Wen-Hsuan ChiangDagger Pei-Ling Tsai Chorng-Shyan Chern Hsin-Cheng Chiu Novel Hybrid Vesicles Co-Assembled from Cationic Lipid and PAAc-g-mPEG with pH-Triggered Transmembrane Channels for Controlled Drug Release Chemical Communications 2011 47 10978-10980
20
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-5 Sep 13 2014 (Sat) 1140-1210 at NTHU BMES R120 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and Imaging
Applications
Wen-Hsuan Chiang
Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
In order to promote therapeutic efficacy and minimize side effect equipping these nanocarriers with the
capability of controlling drug release in response to an appropriate stimulus is essentially required Acidic pH
as an internal stimulus is particular appealing because of the mildly acid pH encountered in tumor tissues and
the intracellular compartments such as endosomes and lysosomes Therefore the pH-responsive drug carriers
have been extensively developed for improving intracellular drug delivery To realize the pH-responsive drug
release we adopted a simple approach to design the lipidPEG-containing complex vesicles with pH-triggered
transmembrane channels as a chemotherapy drug doxorubicin (DOX) delivery carrier In this study the
complex vesicles were attained by spontaneous co-assembly of poly(acrylic acid)-g-poly(monomethoxy
ethylene glycol) (PAAc-g-mPEG) with a cationic lipid didodecyldimethylammonium bromide (DDAB) in
aqueous phase of pH 89 via electrostatic interactions Through the formation of unionized AAc-rich
transmembrance channels of complex vesicles in weak acidic environments the acid-triggered rapid drug
release can be achieved
On the other hand for simultaneously monitoring disease progression and biological response after
treatments we developed a novel tumor-targeting polymersome system capable of delivering magnetic
resonance imaging (MRI) and chemotherapy The DOX-loaded magnetic polymersomes were first attained by
the self-assembly of lipid-containing copolymer poly(AAc-co-distearin acrylate) in aqueous solution
containing citric acid-coated superparamagnetic iron oxide nanoparticles (SPIONs) and followed by DOX
loading via electrostatic attraction To further functionalize these vesicles with superior in vivo colloidal
stability pH-tunable drug release and active tumor-targeting chitosan and poly( -glutamic
acid-co- -glutamyl oxysuccinimide)-g-PEG-folate (FA) were deposited in sequence onto the assembly outer
surfaces The interfacial nanogel layers via electrostatic interactions and in-situ covalent cross-linking were
thus produced Triggerable release of the encapsulated DOX was governed by dual external stimuli pH and
temperature When these theranostic NCPs were effectively internalized by HeLa cells via FA
receptor-mediated endocytosis and then exposed to high frequency magnetic fields (HFMF) the combined
effects of both pH and magnetic hyperthermia-triggered drug release and thermo-therapy resulted in greater
cytotoxicity than the treatment by DOX alone By virtue of the SPION clustering effect in the assembly inner
aqueous compartments the SPIONDOX-loaded NCPs displayed an r2 relaxivity value higher than Resovist
a commercial SPION-based T2 contrast agent The high magnetic relaxivity of the tumor-targeting NCPs
coupled with their enhanced cellular uptake considerably promoted the MRI contrast of targeted cancer cells
These results demonstrate the great potential of the FA-decorated SPIONDOX-loaded NCPs as an advanced
cancer theranostic nanodevice
21
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-1 Prof Hao-Li Liu Professor and Director
Department of Electrical Engineering
Chang Gung University
Phone +886-3-2118800 ext 5677
Fax +886-3-2118026
E-mail haoliliumailcguedutw
Education 2003 PhD National Taiwan University Taipei TAIWAN 1998 M S National Taiwan University Taipei TAIWAN 1996 B S National Taipei University of Technology TAIWAN
Professional Experience 2012-present Director Dept of Electrical Engineering Chang Gung Univ Taiwan 2011-present Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2008 Associate Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2005 ndash2008 Assistant Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2004 ndash2005 Research Fellow Department of Radiology Brigham amp Womenrsquos Hospital Harvard Medical School MA USA
Honor and awards (2009~) 2013 Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) 2013 The 2013 Frederick Lizzi Award International Society of Therapeutic Ultrasound 2011 Distinguished Tech-Coop Award (長庚大學優良教師技合獎) Chang-Gung University 2011 Wu Ta-You Memorial Award (吳大猷先生紀念獎) National Science Council Taiwan 2011 2010 Distinguished Research Award (長庚大學優良教師研究獎) Chang-Gung University
Selected Publication (2010~) HW Yang MY Hua TL Hwang KJ Lin CY Huang RY Tsai CCM Ma PH Hsu SP Wey PW Hsu PY Chen YC Huang YJ Lu TC Yen LY Feng CW Lin HL Liu KC Wei Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide Advanced Materials Vol 25 No 26 pp3605-3611 2013 HL Liu CH Fan CY Ting and CK Yeh Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors Theranostics Vol 4 No 4 pp432-444 2014 KC Wei PC Chu HYJ Wang CY Huang PY Chen HC Tsai YJ Lu IC Tseng PY Lee TC Yen and HL Liu Focused Ultrasound-induced BloodndashBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment A Preclinical Study PLoS ONE Vol 8 No 3 pp e58995 2013 P-H Hsu K-C Wei C-Y Huang C-J Wen T-C Yen C-L Liu Y-T Lin J-C Chen C-R Shen and H-L Liu Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound PLoS ONE Vol 8 No 2 pp e57682 2013 H-L Liu M-Y Hua H-W Yang C-Y Huang P-C Chu J-S Wua I-C Tseng J-J Wang T-C Yen P-Y Chen and K-C Wei ldquoMagnetic resonance monitoring of focused ultrasoundmagnetic nanoparticle targeting delivery of therapeutic agents to the brainrdquo Proceedings of National Academy of Science USA Vol 107 No 34 pp15205-15210 2010 H-L Liu M-Y Hua P-Y Chen P-C Chu C-H Pan H-W Yang C-Y Huang J-J Wang T-C Yen and K-C Wei ldquoBloodndashBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatmentrdquo Radiology Vol 255 No 2 pp 415-425 2010 H-L Liu Y-Y Wai P-H Hsu L-A Lyu J-S Wu C-R Shen J-C Chen T-C Yen and J-J Wang ldquoIn Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Bloodndashbrain Barrier with Focused Ultrasound A Magnetic Resonance Imaging Studyrdquo Journal of Cerebral Blood Flow amp Metabolism Vol 30 pp 168-177 2010
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
9
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Program
September 12 (Fri) 2014
Time Agenda Speaker
1900~2100 Welcome and Opening Ceremony (Hall of Fame)
September 13 (Sat) 2014 Place NTHU BMES
Time Agenda Speaker
0830~0900 Registration (Entrance Hall NTHU BMES)
0900~0915 Opening Remarks Symposium Chairs
Session A Biomaterials Moderator Hsin-Cheng Chiu (NTHU) Ryo Ishihara (TUS)
0915~0945 Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes (Keynote)
Prof Yung Chang張
雍
0945~1015 Chemical Modifications for the Developments of Next Generation
Drugs (Keynote)
Prof Yutaka Ikeda
池田豊
1015~1045 Electrospun Composite Nanofibers with Staged Release of Multiple
Angiogenic Growth Factors for Chronic Wound Healing (Keynote)
Prof Tzu-Wei Wang
王子威
1045~1110 Break
1110~1140 Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip
toward Point-of-Care Diagnosis (invited)
Prof Ryo Ishihara石
原量
1140~1210 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and
Imaging Applications (Invited)
Dr Wen-Hsuan
Chiang姜文軒
1200~1330 Lunch
Session B Biomedical Imaging Moderator Chih-Kuang Yeh (NTHU) Kohei Soga (TUS)
1320~1400 Focused-Ultrasound Brain-Drug Delivery Approach and
Application (Keynote)
Prof Hao-Li Liu劉
浩澧
1400~1440 Responsive and Theranostic Nano-Contrast Agents for Preclinical
MR Imaging (Keynote)
Dr Ichio Aoki青木
伊知男
1440~1510 Observation of Single-Molecule Enzymes through Probes under the
Optical Microscope (Keynote)
Prof Tomoko
Masaike政池知子
1510~1630 Break
1630~1710 Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing
SPIO Nanoparticles Ultrasonically (Invited)
Prof Meng-Lin Li
李夢麟
1710~1740 High resolution ultrasound elastography for medical applications
(Invited)
Prof Chih-Chung
Huang黃執中
1740~1810 Biofunctional Polymers for Application of Ceramic Nanoparticles
for Fluorescence Bioimaging (Invited)
Prof Masao
Kamimura上村真生
1900~ Banquet (合口味)
10
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
September 14 (Sun) 2014 Place NTHU BMES
Time Agenda Speaker
0845~0900 Registration
Session C Science and Technology for Environment amp Energy
Moderator Yu-Fen Huang (NTHU) Keishi Nishio (TUS)
0900~0930 Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed
Tungsten Oxide Thin Films for Hydrogen Gas Sensor (Keynote)
Prof Keishi Nishio
西尾圭史
0930~1000 Control of low-concentration gaseous mercury from stationary
sources via adsorption and oxidation (Keynote)
Prof Hsing-Cheng
His席行正
1000~1030 High-Throughput Functional Materials Exploration by
Combinatorial WetDry Process (Keynote)
Prof Kenjiro
Fujimoto藤本憲次
郎
1030~1050 Break
1050~1120 Facile Manufacturing on Energy-efficient Devices with Flexibility
and Antireflection (Invited)
Prof Fu-Hsiang Ko
柯富祥
1120~1150 Proton Distribution and Dynamics in BaZrO3-Based Proton
Conductor for Solid Oxide Fuel Cell (Invited)
Prof Naoto
Kitamura北村尚斗
1150~1220 Harvesting Water Energy by a Sequential Contact-Electrification and
Electrostatic-Induction Process (Invited)
Prof Zong-Hong
Lin林宗宏
1210~1330 Lunch
Poster Session
1330~1530 Poster Session
1600~1800 Move to I-Lan
1800~2000 Luodong Night Market
2000 National Center for Traditional Art I-Lan (宜蘭傳藝)
September 15 (Mon) 2014 Place I-Lan
Time Agenda Speaker
0700~0800 Breakfast
0845~0910 Closing Remarks
(National Center for Traditional Art I-Lan)
0910~1500 Visit National Center for Traditional Art
1150~1330 Lunch
1530 Move to Taipei Railway Station or Hsinchu
11
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker
Invited Speaker A-1 Prof Yung Chang
Distinguished Professor
Department of Chemical Engineering
Deputy Director RampD Center for Membrane Technology
Chung Yuan Christian University
Address Jhong-Li Taoyuan 320 Taiwan
TEL (886) 265-4122
FAX (886) 265-4190
Education 2004 PhD Chemical Engineering National Taiwan University Taiwan 2000 MS Chemical Engineering National Taiwan University Taiwan 1998 BS Chemical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013-present Deputy Director RampD Center for Membrane Technology Chung Yuan Christian
University 2013-present Distinguished Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2013-present Professor Department of Chemical Engineering Chung Yuan Christian University
Taiwan 2009-2013 Associate Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2006-2009 Assistant Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2005-2006 Postdoctoral Fellow Chemical Engineering University of Washington USA 2004-2005 Postdoctoral Fellow Chemical Engineering National Taiwan University Taiwan
Honor and awards (2010~) 2010 Yung Investigator Award of Chemical Engineering (Taiwan Institute of Chemical Engineers) 2010 Yung Investigator Award of Materials on Regenerative Medicine (National Health Research
Institutes Taiwan) 2011 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan) 2011 Outstanding Research Award of Chemical Engineering (LCY Chemical Corp) 2012 NSC Wu Da-Yu Award (National science council Taiwan) 2012 NSC Outstanding AcademicIndustrial Cooperation Award (National science council) 2013 Yung Investigator Award of Polymer Science (Taiwan Institute of Polymer Science) 2013 JCS The Distinguished Lectureship Award Biomaterial Research (Japan Chemical Society) 2013 Ukraine International Invention Exhibition Gold Medal (Ukraine Invention Society) 2014 Pittsburgh International Invention Exhibition Gold Medal (USA Invention Society) 2014 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan)
12
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-1 Sep 13 2014 (Sat) 0915-0945 at NTHU BMES R120
Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes
Chung Yuan
RampD Center for Membrane Technology and Department of Chemical Engineering Christian
University Chung-Li Taoyuan 320 Taiwan
Zwitterionic polymeric interface resisting the adsorption of plasma proteins is important in the
development of blood-contacting biomaterials in such applications as blood collection devices
antithrombogenic implants hemodialysis membranes drug-delivery carriers and diagnostic
biosensors Previous studies showed that the control of surface charge neutrality is important for a
zwitterionic surface with effective protein-resistant properties Importantly it was further reported
that the mixed-charge formulation in self-assembled monolayers copolymer hydrogels and
polymeric brushes provide a new avenue to achieve nonfouling surfaces with the prevention of
nonspecific protein adsorption if the charge balance can be well controlled This talk will cover three
major studies
Bio-inert nature of biomimetic zwitterionicpseudozwitterionic structures
Blood-Inert
Surfaces via ion-pair anchoring of zwitterionic copolymer brushes in human whole blood Surface
zwitterionization of membrenaes in novel biomedical applications
[1] Chang Y Liao SC Higuchi A Ruaan RC Chu CW Chen WY A highly stable nonbiofouling surface with
well-packed grafted zwitterionic polysulfobetaine for plasma protein repulsion Langmuir 2008245453-58
[2] Chiag YC Chang Y Higuchi A Chen WY Ruaan RC Sulfobetaine-grafted poly(vinylidene fluroride) ultrafiltration
membranes exhibit excellent antifouling property Journal of Membrane Science 2009339151-9
[3] Chang Y Yandi W Chen WY Shih YJ Yang CC Chang Y Ling QD Higuchi A Tunable bioadhesive copolymer
hydrogels of thermoresponsive poly(N-isopropyl acrylamide) containing zwitterionic polysulfobetaine
Biomacromolecules 2010111101-10
[4] Chang Y Chang WJ Shih YJ Wei TC Hsiue GH Zwitterionic sulfobetaine-grafted poly(vinylidene fluoride)
membrane with improved blood compatibility via atmospheric plasma-induced surface copolymerization ACS Appl
Mater Interfaces 201131228-37
[5] Shih YJ Chang Y Deratani A Damien Q Schizophrenic hemocompatible copolymers via switchable
thermoresponsive transition of nonioniczwitterionic block self-assembly in human blood Biomacromolecules
2012132849minus58
[6] Chang Y Shih YJ Lai CJ Kung HH Jiang S Ion-pair anchoring of self-assembled zwitterionic copolymer surfaces
with highly controlled blood compatibility Advanced Functional Materials 2013231100-10
13
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-2 Dr Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences
University of Tsukuba
Address Tennoudai 1-1-1 Tsukuba Ibaraki 305-8573 Japan
E-mailikedaimstsukubaacjp
Education March 1999 B S in Faculty of Engineering Kyoto University March 2001 MS in Graduate School of Engineering Department of Synthetic Chemistry and
Biological Chemistry Kyoto University March 2004 PhD in School of Engineering The University of Tokyo
Professional Experience 2004~2006 Advanced industrial science and technology (AIST) 2006~2008 Cytopathfinder Inc 2008~to date University of Tsukuba
Selected Publication (2010~) Y Ikeda J Katamachi H Kawasaki Y Nagasaki Novel protein PEGylation chemistry via glutalaldehydefunctionalized PEG Bioconjugate Chemistry 24 1824-1827 (2013) Y Ikeda D Kubota Y Nagasaki Design of sugar-oligonucleotide conjugates installed gold nanoparticle for effective delivery to hepatic parenchymal cells Colloid and Polymer Science 291 2959-2964 Y Ikeda H Kawasaki S Ichinohe Y Nagasaki Facile solid-phase synthesis of a highly stable poly(ethylene glycol)-oligonucleotide conjugate Journal of Materials Chemistry B 1 529-535(2013) Y Ikeda T Jomura U Horiuchi J Saeki K Yoshimoto T Ikeya Y Nagasaki Long-term survival and functional maintenance of hepatocytes by using a microfabricated cell array Colloid and Surface B Biointerface 97 97-100 2012 Y Ikeda Y Nagasaki PEGylation Technology in Nanomedicine Advances in Polymer Science 247 115-140 2012 Y Ikeda R Suzuki T Yoshitomi Y Nagasaki Novel oligonucleotide carrier possessing reactive oxygen species scavenging ability Macromolecular Bioscience 2011 11 344-351 Y Ikeda D Kubota Y Nagasaki Simple solid-phase synthesis and biological properties of carbohydrate-oligonucleotide conjugates modified at the 3rsquo terminus Bioconjugate Chem 2010 21 1685-1690
14
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-2 Sep 13 2014 (Sat) 0945-1015 at NTHU BMES R120
Chemical Modifications for the Developments of Next Generation Drugs
Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences University of
Tsukuba
Controlling of biodistribution and PKPD is a key issue for the development of drugsVariety of
technologies have been reported to improve those properties Those technologies include
nanoparticle formulation and PEGylation technology In my presentation I will show recent
chemical modification technologies which we developed to improve PKPD and distribution of
drugs
A novel chemistry for the PEGylated protein with a high activity
Several PEGylated proteins have been approved as therapeutic drugs In many cases PEGylated
protein has been synthesized by the conjugation reaction between PEG possessing activated ester and
amine(s) in the protein This reaction however often causes inactivation of PEGylated proteins In
this report we present a novel chemistry which enables the PEGylation of proteins under the mild
reaction condition PEGylated lysozyme prepared by the method developed increased the biological
activity of the PEGylated lysozyme more than 20 times compared with the PEGylated lysozyme
prepared by the conventional method
Design and development of novel hypoxically activated prodrugs
Tumor hypoxia is well known to promote mutagenesis invasiveness and to be associated with a
worse prognosis Although the treatment of the tumor hypoxia has been highly demanded resistance
to radiotherapy and anticancer chemotherapy have been serious problems The object of this study
was the development of hypoxically activated prodrugs which accumulate and act on cells at hypoxic
region of tumor Several conventional anti-cancer drugs including doxorubicin gemcitabine and 5FU
have been modified with 2-nitro imidazole derivative This modification enabled inactivation of drug
to reduce adverse effects under the normoxia condition and selective activation of prodrug under the
hypoxic condition
15
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-3 Prof Tzu-Wei Wang
Associate Professor
Department of Materials Science and Engineering and Institute of Biomedical
Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013
Office Delta Teaching Building R434
TEL +886-3-5715131 ext 33856
Email twwangmxnthuedutw Education 2006 PhD Institute of Biomedical Engineering National Taiwan University Taiwan
Professional Experience 2013 ndashpresent Associate Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2009 -2013 Assistant Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2007-2009 Postdoctoral Research Fellow Tissue Engineering Laboratories of Brigham and Womenrsquos
Hospital Harvard Medical School USA
Honor and awards (2009~) Young Plenary Award 2013 TERMIS-AP Symposium Shanghai China (2013) The 9th National Innovation Award Academic Research Category by Institute for Biotechnology and Medicine Industry Taiwan (2012) Young Investigator Award International Symposium of Materials on Regenerative Medicine Taiwan (2012 ISOMRM) Young Investigator Award 5th World Congress on Bioengineering the World Association for Chinese Biomedical Engineers Taiwan (WACBE 2011)
Selected Publication (2012~) Yang CS Wu HC Sun JS Hsiao HM Wang TW Thermo-induced shape memory PEG-PCL copolymer as dual drug-eluting biodegradable stent ACS Appl Mater Interfaces 2013 5 (21) 10985ndash10994 Yeh PH Sun JS Wu HC Hwang LH Wang TW Stimuli-responsive HA-PEI nanoparticles encapsulating endostatin plasmid for stem cell gene therapy RSC Advances 2013 3 (31) 12922 - 12932 Chen YY Wu HC Sun JS Dong GC Wang TW Injectable and thermoresponsive self-assembled nanocomposite hydrogel for long-term anticancer drug delivery Langmuir 201329(11)3721-3729 Cheng TY Wu HC Chang WH Huang MY Lee CH Wang TW Self-assembling functionalized nanopeptides for immediate hemostasis and accelerative liver tissue regeneration Nanoscale 2013 5 (7) 2734 - 2744 Chang YJ Tsai CJ Tseng FG Chen TJ Wang TW Micropatterned Stretching System for the Investigation of Mechanical Tension on Neural Stem Cells Behavior Nanomedicine Nanotechnology Biology and Medicine 20139345-355 Cheng TY Chen MH Chang WH Huang MY Wang TW Neural stem cells encapsulated in a functionalized self-assembling peptide hydrogel for brain tissue engineering Biomaterials 2013 34(8)2005-2016 Goh JH Wu HC Chen MH Chen MY Chang SC Wang TW Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages Acta Biomaterialia 20139(2)5170-5180 Huang YJ Wu HC Tai NH Wang TW Carbon Nanotube Rope with Electrical Stimulation Promotes the Differentiation and Maturity of Neural Stem Cells Small 20128(18) 2869ndash2877
16
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-3 Sep 13 2014 (Sat) 1015-1045 at NTHU BMES R120
Electrospun Composite Nanofibers with Staged Release of Multiple Angiogenic Growth Factors for Chronic Wound Healing
Tzu-Wei Wang
Department of Materials Science and Engineering and Institute of Biomedical Engineering National
Tsing Hua University
The objective of this research study is to develop collagen (Col) and hyaluronic acid (HA)
inter-stacking nanofibrous skin equivalent substitute with programmable release of multiple
angiogenic growth factors (VEGF PDGF bFGF and EGF) either directly embedded in the
nanofibers or encapsulated in the gelatin nanoparticles (GN) by electrospinning technology The
delivery of EGF and bFGF in early stage is expected to accelerate epithelialization and vasculature
sprouting while release of PDGF and VEGF in late stage is aimed for the induction of blood vessels
maturation The physiochemical characterizations report that the Col-HA-GN nanofibrous membrane
possesses mechanical property similar to human native skin The design of particle-in-fiber structure
allows growth factors for slow controlled release up to one month Cultured on biodegradable
Col-HA membrane with four kinds of growth factors (Col-HA w4GF) endothelial cells not only
increase in growth rate but also form better network of thread-like tubular structure Therapeutic
effect of Col-HA w4GF membrane on STZ-induced diabetic rats reveal accelerated wound closure
rate elevated collagen deposition and enhanced mature vessels by Massonrsquos trichrome stain and
immunohistochemical analysis respectively From the above the electrospun Col-HA-GN composite
nanofibrous skin substitute with stage-wise release pattern of multiple angiogenic factors could be a
promising bioengineered construct for the chronic wound healing in skin tissue regeneration
17
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-4 Assistant Prof Ryo Ishihara
Assistant Professor
Department of Materials Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
Tokyo University of Science Research Building 9th floor
TEL +81-3-5876-1415
FAX +81-3-5876-1415
Education 2012 PhD Department of Applied Chemistry and Biotechnology Chiba University Japan 2008 MS Department of Materials Technology Chiba University Japan 2006 BS Department of Materials Technology Chiba University Japan
Professional Experience 2014 ndashpresent Assistant Professor Department of Materials Science and Technology Tokyo
University of Science 2012 ndash2014 Postdoctral Researcher Bioengineering Laboratory RIKEN
Honor and awards Department chairmanlsquos award from Chiba University (2012)
Selected Publication (2010~) Simple Method for High-Density Impregnation of Aliquat 336 onto Porous Sheet and Binding Performance of Resulting Sheet for Palladium Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota Sep Sci Technol 49154-159 (2014) Effect of Dose on Mole Percentage of Polymer Brush and Root Grafted onto Porous Polyethylene Sheet by Radiation-Induced Graft Polymerization R Ishihara S Uchiyama H Ikezawa S Yamada H Hirota D Umeno K Saito Ind Eng Chem Res 5212582-12586 (2013) Determination of Mole Percentages of Brush and Root of Polymer Chain Grafted onto Porous Sheet S Uchiyama R Ishihara D Umeno K Saito S Yamada H Hirota S Asai J Chem Eng Japan 46414-419 (2013) Crosslinked-chelating Porous Sheet with High Dynamic Binding Capacity of Metal Ions G Wada R Ishihara K Miyoshi D Umeno K Saito S Yamada H Hirota Solv Extr Ion Exch 31210-220 (2013) Dependence of Lanthanide-Ion Binding Performance on HDEHP Concentration in HDEHP Impregnation to Porous Sheet R Ishihara S Asai S Otosaka S Yamada H Hirota K Miyoshi D Umeno K Saito Solv Extr Ion Exch 30171-180 (2012) Impregnation of TOPO onto Hydrophobic-Ligand-Containing Porous Sheet and Its Adsorptionelution Performance of Bismuth Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota React Funct Polym 70986-990 (2010)
18
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-4 Sep 13 2014 (Sat) 1110-1140 at NTHU BMES R120
Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip toward Point-of-Care Diagnosis
Ryo Ishihara Kazuo Hosokawa Mizuo Maeda
Bioengineering Laboratory RIKEN
MicroRNAs (miRNAs) are short and non-protein-coding single-stranded RNAs and have shown great promise for
cancer diagnosis Some miRNAs circulate in human body fluid with extremely low concentrations and its expression
profiling can detect and classify cancers in the human body [1] Point-of-care (POC) diagnosis requires short detection
time small required sample volume and portability of the device In various miRNA detection methods microfluidic
chip meets the requirements except the portability Hence we used our power-free pump-free microfluidic chip driven
by energy that is stored in degased PDMS to overcome those drawbacks which eliminates the need for external power
sources for fluid pumping [2] The pump-free pumping method is essential for microfluidic chip-based POC diagnosis In
our laboratory rapid and sensitive singleplex miRNA detection with laminar flow-assisted dendritic amplification (LFDA)
[3] on the pump-free microfluidic chip has been developed [4] In this study rapid and sensitive multiplex miRNA
detection on the pump-free microfluidic chip was demonstrated
Pump-free microchip for multiplex miRNA detection was prepared as follows First the PDMS part with a pair of
Y-shaped microchannels with 100 μm in width and 25 μm in height was fabricated Second three parallel-line-shaped
probe DNAs were patterned onto a glass surface Third the PDMS channels were attached onto the glass plate Finally
the chip was degassed in a vacuum chamber After the chip preparation target miRNAs were detected following three
steps (1) blocking (2) sandwich hybridization of the target miRNAs and biotinylated probe DNAs and (3) signal
amplification by LFDA MiR-16 miR-21-5p and miR-500a-3p were used as target miRNAs since they are known as
cancer biomarkers [5-7] Fluorescence signals were captured by CCD camera and analyzed by the software (ImageJ)
Bright lines appeared at the expected positions they appeared only on the areas with the respective probe DNA in which
the target miRNAs had been supplied These data prove that the LFDA successfully took place in a target
sequence-dependent manner Calibration curves were plotted from the fluorescence signals The data points of the
calibration curve were fitted with the four-parameter logistic function and limit-of-detections (LODs) were evaluated by
the 3σ criterion LODs of the miR-16 miR-21-5p and miR-500a-3p were 68 fM 15 pM and 150 fM respectively The
LODs are on the same order of magnitude as concentrations of miRNA in blood Multiplex detection was verified from
correspondence between the calibration curves of single and multiplex The required sample volume was 05 microL and
assay time was 20 min Because most of the existing methods take more than a few hours the rapidness small required
sample volume and portability of the device are ideal advantages for POC diagnosis
References
[1] PS Mitchell et al PNAS 105 (2008) 10513 [2] K Hosokawa et al Lab Chip 4 (2004) 181 [3] K Hosokawa et al Anal
Chem 79 (2007) 6000 [4] H Arata et al PLoS ONE 7 (2012) e48329 [5] MJ Lodes et al PLoS ONE 4 (2009) e6229
[6] Y Toiyama et al J Natl Cancer Inst 105 (2013) 849 [7] Y Yamamoto et al Biomarkers 14 (2009) 529
19
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-5 Dr Wen-Hsuan Chiang
Assistant Researcher
Department of Biomedical Engineering and Environmental Sciences
National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
TEL (886) 3-571-5131 ext 35576
Education 2009 PhD Department of Chemical Engineering National Chung Hsing University Taiwan Thesis Supervisor Professor Hsin-Cheng Chiu 2002 BS Department of Chemical Engineering Tatung University Taiwan Professional Experience 2013 ndashpresent Assistant Researcher Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University 2010 ndash2012 Postdoctoral Fellow Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
Areas of Research Expertise Biomaterials Smart Amphiphilic Copolymers Multifunctional Nanocarriers for Cancer Therapy and Imaging Nano Science and Interfacial Engineering
Selected Publication (2010~) Wen-Hsuan Chiang Wen-Chia Huang Ming-Yin Shen Che-Hsu Wang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Dual-Layered Nanogel-Coated Hollow LipidPolypeptide Conjugate Assemblies for Potential pH-Triggered Intracellular Drug Release PLOS ONE 2014 9 1-11 Wen-Hsuan Chiang Wen-Chia Huang Chien-Wen Chang Ming-Yin Shen Zong-Fu Shih Yi-Fong Huang Sung-Chyr Lin Hsin-Cheng Chiu Functionalized Polymersomes with Outlayered Polyelectrolyte Gels for Potential Tumor-Targeted Delivery of Multimodal Therapies and MR Imaging Journal of Controlled Release 2013 168 280-288 Wen-Hsuan Chiang Viet Thang Ho Hsin-Hung Chen Wen-Chia Huang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Superparamagnetic Hollow Hybrid Nanogels as a Potential Guidable Vehicle System of Stimuli-Mediated MR Imaging and Multiple Cancer Therapeutics Langmuir 2013 29 6434-6443 Wen-Hsuan Chiang Viet Thang Ho Wen-Chia Huang Yi-Fong Huang Chorng-Shyan Chern Hsin-Cheng Chiu Dual Stimuli-Responsive Polymeric Hollow Nanogels Designed as Carriers for Intracellular Triggered Drug Release Langmuir 2012 28 15056-15064 Yi-Fong HuangDagger Wen-Hsuan ChiangDagger Pei-Ling Tsai Chorng-Shyan Chern Hsin-Cheng Chiu Novel Hybrid Vesicles Co-Assembled from Cationic Lipid and PAAc-g-mPEG with pH-Triggered Transmembrane Channels for Controlled Drug Release Chemical Communications 2011 47 10978-10980
20
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-5 Sep 13 2014 (Sat) 1140-1210 at NTHU BMES R120 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and Imaging
Applications
Wen-Hsuan Chiang
Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
In order to promote therapeutic efficacy and minimize side effect equipping these nanocarriers with the
capability of controlling drug release in response to an appropriate stimulus is essentially required Acidic pH
as an internal stimulus is particular appealing because of the mildly acid pH encountered in tumor tissues and
the intracellular compartments such as endosomes and lysosomes Therefore the pH-responsive drug carriers
have been extensively developed for improving intracellular drug delivery To realize the pH-responsive drug
release we adopted a simple approach to design the lipidPEG-containing complex vesicles with pH-triggered
transmembrane channels as a chemotherapy drug doxorubicin (DOX) delivery carrier In this study the
complex vesicles were attained by spontaneous co-assembly of poly(acrylic acid)-g-poly(monomethoxy
ethylene glycol) (PAAc-g-mPEG) with a cationic lipid didodecyldimethylammonium bromide (DDAB) in
aqueous phase of pH 89 via electrostatic interactions Through the formation of unionized AAc-rich
transmembrance channels of complex vesicles in weak acidic environments the acid-triggered rapid drug
release can be achieved
On the other hand for simultaneously monitoring disease progression and biological response after
treatments we developed a novel tumor-targeting polymersome system capable of delivering magnetic
resonance imaging (MRI) and chemotherapy The DOX-loaded magnetic polymersomes were first attained by
the self-assembly of lipid-containing copolymer poly(AAc-co-distearin acrylate) in aqueous solution
containing citric acid-coated superparamagnetic iron oxide nanoparticles (SPIONs) and followed by DOX
loading via electrostatic attraction To further functionalize these vesicles with superior in vivo colloidal
stability pH-tunable drug release and active tumor-targeting chitosan and poly( -glutamic
acid-co- -glutamyl oxysuccinimide)-g-PEG-folate (FA) were deposited in sequence onto the assembly outer
surfaces The interfacial nanogel layers via electrostatic interactions and in-situ covalent cross-linking were
thus produced Triggerable release of the encapsulated DOX was governed by dual external stimuli pH and
temperature When these theranostic NCPs were effectively internalized by HeLa cells via FA
receptor-mediated endocytosis and then exposed to high frequency magnetic fields (HFMF) the combined
effects of both pH and magnetic hyperthermia-triggered drug release and thermo-therapy resulted in greater
cytotoxicity than the treatment by DOX alone By virtue of the SPION clustering effect in the assembly inner
aqueous compartments the SPIONDOX-loaded NCPs displayed an r2 relaxivity value higher than Resovist
a commercial SPION-based T2 contrast agent The high magnetic relaxivity of the tumor-targeting NCPs
coupled with their enhanced cellular uptake considerably promoted the MRI contrast of targeted cancer cells
These results demonstrate the great potential of the FA-decorated SPIONDOX-loaded NCPs as an advanced
cancer theranostic nanodevice
21
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-1 Prof Hao-Li Liu Professor and Director
Department of Electrical Engineering
Chang Gung University
Phone +886-3-2118800 ext 5677
Fax +886-3-2118026
E-mail haoliliumailcguedutw
Education 2003 PhD National Taiwan University Taipei TAIWAN 1998 M S National Taiwan University Taipei TAIWAN 1996 B S National Taipei University of Technology TAIWAN
Professional Experience 2012-present Director Dept of Electrical Engineering Chang Gung Univ Taiwan 2011-present Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2008 Associate Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2005 ndash2008 Assistant Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2004 ndash2005 Research Fellow Department of Radiology Brigham amp Womenrsquos Hospital Harvard Medical School MA USA
Honor and awards (2009~) 2013 Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) 2013 The 2013 Frederick Lizzi Award International Society of Therapeutic Ultrasound 2011 Distinguished Tech-Coop Award (長庚大學優良教師技合獎) Chang-Gung University 2011 Wu Ta-You Memorial Award (吳大猷先生紀念獎) National Science Council Taiwan 2011 2010 Distinguished Research Award (長庚大學優良教師研究獎) Chang-Gung University
Selected Publication (2010~) HW Yang MY Hua TL Hwang KJ Lin CY Huang RY Tsai CCM Ma PH Hsu SP Wey PW Hsu PY Chen YC Huang YJ Lu TC Yen LY Feng CW Lin HL Liu KC Wei Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide Advanced Materials Vol 25 No 26 pp3605-3611 2013 HL Liu CH Fan CY Ting and CK Yeh Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors Theranostics Vol 4 No 4 pp432-444 2014 KC Wei PC Chu HYJ Wang CY Huang PY Chen HC Tsai YJ Lu IC Tseng PY Lee TC Yen and HL Liu Focused Ultrasound-induced BloodndashBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment A Preclinical Study PLoS ONE Vol 8 No 3 pp e58995 2013 P-H Hsu K-C Wei C-Y Huang C-J Wen T-C Yen C-L Liu Y-T Lin J-C Chen C-R Shen and H-L Liu Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound PLoS ONE Vol 8 No 2 pp e57682 2013 H-L Liu M-Y Hua H-W Yang C-Y Huang P-C Chu J-S Wua I-C Tseng J-J Wang T-C Yen P-Y Chen and K-C Wei ldquoMagnetic resonance monitoring of focused ultrasoundmagnetic nanoparticle targeting delivery of therapeutic agents to the brainrdquo Proceedings of National Academy of Science USA Vol 107 No 34 pp15205-15210 2010 H-L Liu M-Y Hua P-Y Chen P-C Chu C-H Pan H-W Yang C-Y Huang J-J Wang T-C Yen and K-C Wei ldquoBloodndashBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatmentrdquo Radiology Vol 255 No 2 pp 415-425 2010 H-L Liu Y-Y Wai P-H Hsu L-A Lyu J-S Wu C-R Shen J-C Chen T-C Yen and J-J Wang ldquoIn Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Bloodndashbrain Barrier with Focused Ultrasound A Magnetic Resonance Imaging Studyrdquo Journal of Cerebral Blood Flow amp Metabolism Vol 30 pp 168-177 2010
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
10
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
September 14 (Sun) 2014 Place NTHU BMES
Time Agenda Speaker
0845~0900 Registration
Session C Science and Technology for Environment amp Energy
Moderator Yu-Fen Huang (NTHU) Keishi Nishio (TUS)
0900~0930 Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed
Tungsten Oxide Thin Films for Hydrogen Gas Sensor (Keynote)
Prof Keishi Nishio
西尾圭史
0930~1000 Control of low-concentration gaseous mercury from stationary
sources via adsorption and oxidation (Keynote)
Prof Hsing-Cheng
His席行正
1000~1030 High-Throughput Functional Materials Exploration by
Combinatorial WetDry Process (Keynote)
Prof Kenjiro
Fujimoto藤本憲次
郎
1030~1050 Break
1050~1120 Facile Manufacturing on Energy-efficient Devices with Flexibility
and Antireflection (Invited)
Prof Fu-Hsiang Ko
柯富祥
1120~1150 Proton Distribution and Dynamics in BaZrO3-Based Proton
Conductor for Solid Oxide Fuel Cell (Invited)
Prof Naoto
Kitamura北村尚斗
1150~1220 Harvesting Water Energy by a Sequential Contact-Electrification and
Electrostatic-Induction Process (Invited)
Prof Zong-Hong
Lin林宗宏
1210~1330 Lunch
Poster Session
1330~1530 Poster Session
1600~1800 Move to I-Lan
1800~2000 Luodong Night Market
2000 National Center for Traditional Art I-Lan (宜蘭傳藝)
September 15 (Mon) 2014 Place I-Lan
Time Agenda Speaker
0700~0800 Breakfast
0845~0910 Closing Remarks
(National Center for Traditional Art I-Lan)
0910~1500 Visit National Center for Traditional Art
1150~1330 Lunch
1530 Move to Taipei Railway Station or Hsinchu
11
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker
Invited Speaker A-1 Prof Yung Chang
Distinguished Professor
Department of Chemical Engineering
Deputy Director RampD Center for Membrane Technology
Chung Yuan Christian University
Address Jhong-Li Taoyuan 320 Taiwan
TEL (886) 265-4122
FAX (886) 265-4190
Education 2004 PhD Chemical Engineering National Taiwan University Taiwan 2000 MS Chemical Engineering National Taiwan University Taiwan 1998 BS Chemical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013-present Deputy Director RampD Center for Membrane Technology Chung Yuan Christian
University 2013-present Distinguished Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2013-present Professor Department of Chemical Engineering Chung Yuan Christian University
Taiwan 2009-2013 Associate Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2006-2009 Assistant Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2005-2006 Postdoctoral Fellow Chemical Engineering University of Washington USA 2004-2005 Postdoctoral Fellow Chemical Engineering National Taiwan University Taiwan
Honor and awards (2010~) 2010 Yung Investigator Award of Chemical Engineering (Taiwan Institute of Chemical Engineers) 2010 Yung Investigator Award of Materials on Regenerative Medicine (National Health Research
Institutes Taiwan) 2011 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan) 2011 Outstanding Research Award of Chemical Engineering (LCY Chemical Corp) 2012 NSC Wu Da-Yu Award (National science council Taiwan) 2012 NSC Outstanding AcademicIndustrial Cooperation Award (National science council) 2013 Yung Investigator Award of Polymer Science (Taiwan Institute of Polymer Science) 2013 JCS The Distinguished Lectureship Award Biomaterial Research (Japan Chemical Society) 2013 Ukraine International Invention Exhibition Gold Medal (Ukraine Invention Society) 2014 Pittsburgh International Invention Exhibition Gold Medal (USA Invention Society) 2014 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan)
12
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-1 Sep 13 2014 (Sat) 0915-0945 at NTHU BMES R120
Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes
Chung Yuan
RampD Center for Membrane Technology and Department of Chemical Engineering Christian
University Chung-Li Taoyuan 320 Taiwan
Zwitterionic polymeric interface resisting the adsorption of plasma proteins is important in the
development of blood-contacting biomaterials in such applications as blood collection devices
antithrombogenic implants hemodialysis membranes drug-delivery carriers and diagnostic
biosensors Previous studies showed that the control of surface charge neutrality is important for a
zwitterionic surface with effective protein-resistant properties Importantly it was further reported
that the mixed-charge formulation in self-assembled monolayers copolymer hydrogels and
polymeric brushes provide a new avenue to achieve nonfouling surfaces with the prevention of
nonspecific protein adsorption if the charge balance can be well controlled This talk will cover three
major studies
Bio-inert nature of biomimetic zwitterionicpseudozwitterionic structures
Blood-Inert
Surfaces via ion-pair anchoring of zwitterionic copolymer brushes in human whole blood Surface
zwitterionization of membrenaes in novel biomedical applications
[1] Chang Y Liao SC Higuchi A Ruaan RC Chu CW Chen WY A highly stable nonbiofouling surface with
well-packed grafted zwitterionic polysulfobetaine for plasma protein repulsion Langmuir 2008245453-58
[2] Chiag YC Chang Y Higuchi A Chen WY Ruaan RC Sulfobetaine-grafted poly(vinylidene fluroride) ultrafiltration
membranes exhibit excellent antifouling property Journal of Membrane Science 2009339151-9
[3] Chang Y Yandi W Chen WY Shih YJ Yang CC Chang Y Ling QD Higuchi A Tunable bioadhesive copolymer
hydrogels of thermoresponsive poly(N-isopropyl acrylamide) containing zwitterionic polysulfobetaine
Biomacromolecules 2010111101-10
[4] Chang Y Chang WJ Shih YJ Wei TC Hsiue GH Zwitterionic sulfobetaine-grafted poly(vinylidene fluoride)
membrane with improved blood compatibility via atmospheric plasma-induced surface copolymerization ACS Appl
Mater Interfaces 201131228-37
[5] Shih YJ Chang Y Deratani A Damien Q Schizophrenic hemocompatible copolymers via switchable
thermoresponsive transition of nonioniczwitterionic block self-assembly in human blood Biomacromolecules
2012132849minus58
[6] Chang Y Shih YJ Lai CJ Kung HH Jiang S Ion-pair anchoring of self-assembled zwitterionic copolymer surfaces
with highly controlled blood compatibility Advanced Functional Materials 2013231100-10
13
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-2 Dr Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences
University of Tsukuba
Address Tennoudai 1-1-1 Tsukuba Ibaraki 305-8573 Japan
E-mailikedaimstsukubaacjp
Education March 1999 B S in Faculty of Engineering Kyoto University March 2001 MS in Graduate School of Engineering Department of Synthetic Chemistry and
Biological Chemistry Kyoto University March 2004 PhD in School of Engineering The University of Tokyo
Professional Experience 2004~2006 Advanced industrial science and technology (AIST) 2006~2008 Cytopathfinder Inc 2008~to date University of Tsukuba
Selected Publication (2010~) Y Ikeda J Katamachi H Kawasaki Y Nagasaki Novel protein PEGylation chemistry via glutalaldehydefunctionalized PEG Bioconjugate Chemistry 24 1824-1827 (2013) Y Ikeda D Kubota Y Nagasaki Design of sugar-oligonucleotide conjugates installed gold nanoparticle for effective delivery to hepatic parenchymal cells Colloid and Polymer Science 291 2959-2964 Y Ikeda H Kawasaki S Ichinohe Y Nagasaki Facile solid-phase synthesis of a highly stable poly(ethylene glycol)-oligonucleotide conjugate Journal of Materials Chemistry B 1 529-535(2013) Y Ikeda T Jomura U Horiuchi J Saeki K Yoshimoto T Ikeya Y Nagasaki Long-term survival and functional maintenance of hepatocytes by using a microfabricated cell array Colloid and Surface B Biointerface 97 97-100 2012 Y Ikeda Y Nagasaki PEGylation Technology in Nanomedicine Advances in Polymer Science 247 115-140 2012 Y Ikeda R Suzuki T Yoshitomi Y Nagasaki Novel oligonucleotide carrier possessing reactive oxygen species scavenging ability Macromolecular Bioscience 2011 11 344-351 Y Ikeda D Kubota Y Nagasaki Simple solid-phase synthesis and biological properties of carbohydrate-oligonucleotide conjugates modified at the 3rsquo terminus Bioconjugate Chem 2010 21 1685-1690
14
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-2 Sep 13 2014 (Sat) 0945-1015 at NTHU BMES R120
Chemical Modifications for the Developments of Next Generation Drugs
Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences University of
Tsukuba
Controlling of biodistribution and PKPD is a key issue for the development of drugsVariety of
technologies have been reported to improve those properties Those technologies include
nanoparticle formulation and PEGylation technology In my presentation I will show recent
chemical modification technologies which we developed to improve PKPD and distribution of
drugs
A novel chemistry for the PEGylated protein with a high activity
Several PEGylated proteins have been approved as therapeutic drugs In many cases PEGylated
protein has been synthesized by the conjugation reaction between PEG possessing activated ester and
amine(s) in the protein This reaction however often causes inactivation of PEGylated proteins In
this report we present a novel chemistry which enables the PEGylation of proteins under the mild
reaction condition PEGylated lysozyme prepared by the method developed increased the biological
activity of the PEGylated lysozyme more than 20 times compared with the PEGylated lysozyme
prepared by the conventional method
Design and development of novel hypoxically activated prodrugs
Tumor hypoxia is well known to promote mutagenesis invasiveness and to be associated with a
worse prognosis Although the treatment of the tumor hypoxia has been highly demanded resistance
to radiotherapy and anticancer chemotherapy have been serious problems The object of this study
was the development of hypoxically activated prodrugs which accumulate and act on cells at hypoxic
region of tumor Several conventional anti-cancer drugs including doxorubicin gemcitabine and 5FU
have been modified with 2-nitro imidazole derivative This modification enabled inactivation of drug
to reduce adverse effects under the normoxia condition and selective activation of prodrug under the
hypoxic condition
15
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-3 Prof Tzu-Wei Wang
Associate Professor
Department of Materials Science and Engineering and Institute of Biomedical
Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013
Office Delta Teaching Building R434
TEL +886-3-5715131 ext 33856
Email twwangmxnthuedutw Education 2006 PhD Institute of Biomedical Engineering National Taiwan University Taiwan
Professional Experience 2013 ndashpresent Associate Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2009 -2013 Assistant Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2007-2009 Postdoctoral Research Fellow Tissue Engineering Laboratories of Brigham and Womenrsquos
Hospital Harvard Medical School USA
Honor and awards (2009~) Young Plenary Award 2013 TERMIS-AP Symposium Shanghai China (2013) The 9th National Innovation Award Academic Research Category by Institute for Biotechnology and Medicine Industry Taiwan (2012) Young Investigator Award International Symposium of Materials on Regenerative Medicine Taiwan (2012 ISOMRM) Young Investigator Award 5th World Congress on Bioengineering the World Association for Chinese Biomedical Engineers Taiwan (WACBE 2011)
Selected Publication (2012~) Yang CS Wu HC Sun JS Hsiao HM Wang TW Thermo-induced shape memory PEG-PCL copolymer as dual drug-eluting biodegradable stent ACS Appl Mater Interfaces 2013 5 (21) 10985ndash10994 Yeh PH Sun JS Wu HC Hwang LH Wang TW Stimuli-responsive HA-PEI nanoparticles encapsulating endostatin plasmid for stem cell gene therapy RSC Advances 2013 3 (31) 12922 - 12932 Chen YY Wu HC Sun JS Dong GC Wang TW Injectable and thermoresponsive self-assembled nanocomposite hydrogel for long-term anticancer drug delivery Langmuir 201329(11)3721-3729 Cheng TY Wu HC Chang WH Huang MY Lee CH Wang TW Self-assembling functionalized nanopeptides for immediate hemostasis and accelerative liver tissue regeneration Nanoscale 2013 5 (7) 2734 - 2744 Chang YJ Tsai CJ Tseng FG Chen TJ Wang TW Micropatterned Stretching System for the Investigation of Mechanical Tension on Neural Stem Cells Behavior Nanomedicine Nanotechnology Biology and Medicine 20139345-355 Cheng TY Chen MH Chang WH Huang MY Wang TW Neural stem cells encapsulated in a functionalized self-assembling peptide hydrogel for brain tissue engineering Biomaterials 2013 34(8)2005-2016 Goh JH Wu HC Chen MH Chen MY Chang SC Wang TW Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages Acta Biomaterialia 20139(2)5170-5180 Huang YJ Wu HC Tai NH Wang TW Carbon Nanotube Rope with Electrical Stimulation Promotes the Differentiation and Maturity of Neural Stem Cells Small 20128(18) 2869ndash2877
16
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-3 Sep 13 2014 (Sat) 1015-1045 at NTHU BMES R120
Electrospun Composite Nanofibers with Staged Release of Multiple Angiogenic Growth Factors for Chronic Wound Healing
Tzu-Wei Wang
Department of Materials Science and Engineering and Institute of Biomedical Engineering National
Tsing Hua University
The objective of this research study is to develop collagen (Col) and hyaluronic acid (HA)
inter-stacking nanofibrous skin equivalent substitute with programmable release of multiple
angiogenic growth factors (VEGF PDGF bFGF and EGF) either directly embedded in the
nanofibers or encapsulated in the gelatin nanoparticles (GN) by electrospinning technology The
delivery of EGF and bFGF in early stage is expected to accelerate epithelialization and vasculature
sprouting while release of PDGF and VEGF in late stage is aimed for the induction of blood vessels
maturation The physiochemical characterizations report that the Col-HA-GN nanofibrous membrane
possesses mechanical property similar to human native skin The design of particle-in-fiber structure
allows growth factors for slow controlled release up to one month Cultured on biodegradable
Col-HA membrane with four kinds of growth factors (Col-HA w4GF) endothelial cells not only
increase in growth rate but also form better network of thread-like tubular structure Therapeutic
effect of Col-HA w4GF membrane on STZ-induced diabetic rats reveal accelerated wound closure
rate elevated collagen deposition and enhanced mature vessels by Massonrsquos trichrome stain and
immunohistochemical analysis respectively From the above the electrospun Col-HA-GN composite
nanofibrous skin substitute with stage-wise release pattern of multiple angiogenic factors could be a
promising bioengineered construct for the chronic wound healing in skin tissue regeneration
17
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-4 Assistant Prof Ryo Ishihara
Assistant Professor
Department of Materials Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
Tokyo University of Science Research Building 9th floor
TEL +81-3-5876-1415
FAX +81-3-5876-1415
Education 2012 PhD Department of Applied Chemistry and Biotechnology Chiba University Japan 2008 MS Department of Materials Technology Chiba University Japan 2006 BS Department of Materials Technology Chiba University Japan
Professional Experience 2014 ndashpresent Assistant Professor Department of Materials Science and Technology Tokyo
University of Science 2012 ndash2014 Postdoctral Researcher Bioengineering Laboratory RIKEN
Honor and awards Department chairmanlsquos award from Chiba University (2012)
Selected Publication (2010~) Simple Method for High-Density Impregnation of Aliquat 336 onto Porous Sheet and Binding Performance of Resulting Sheet for Palladium Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota Sep Sci Technol 49154-159 (2014) Effect of Dose on Mole Percentage of Polymer Brush and Root Grafted onto Porous Polyethylene Sheet by Radiation-Induced Graft Polymerization R Ishihara S Uchiyama H Ikezawa S Yamada H Hirota D Umeno K Saito Ind Eng Chem Res 5212582-12586 (2013) Determination of Mole Percentages of Brush and Root of Polymer Chain Grafted onto Porous Sheet S Uchiyama R Ishihara D Umeno K Saito S Yamada H Hirota S Asai J Chem Eng Japan 46414-419 (2013) Crosslinked-chelating Porous Sheet with High Dynamic Binding Capacity of Metal Ions G Wada R Ishihara K Miyoshi D Umeno K Saito S Yamada H Hirota Solv Extr Ion Exch 31210-220 (2013) Dependence of Lanthanide-Ion Binding Performance on HDEHP Concentration in HDEHP Impregnation to Porous Sheet R Ishihara S Asai S Otosaka S Yamada H Hirota K Miyoshi D Umeno K Saito Solv Extr Ion Exch 30171-180 (2012) Impregnation of TOPO onto Hydrophobic-Ligand-Containing Porous Sheet and Its Adsorptionelution Performance of Bismuth Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota React Funct Polym 70986-990 (2010)
18
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-4 Sep 13 2014 (Sat) 1110-1140 at NTHU BMES R120
Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip toward Point-of-Care Diagnosis
Ryo Ishihara Kazuo Hosokawa Mizuo Maeda
Bioengineering Laboratory RIKEN
MicroRNAs (miRNAs) are short and non-protein-coding single-stranded RNAs and have shown great promise for
cancer diagnosis Some miRNAs circulate in human body fluid with extremely low concentrations and its expression
profiling can detect and classify cancers in the human body [1] Point-of-care (POC) diagnosis requires short detection
time small required sample volume and portability of the device In various miRNA detection methods microfluidic
chip meets the requirements except the portability Hence we used our power-free pump-free microfluidic chip driven
by energy that is stored in degased PDMS to overcome those drawbacks which eliminates the need for external power
sources for fluid pumping [2] The pump-free pumping method is essential for microfluidic chip-based POC diagnosis In
our laboratory rapid and sensitive singleplex miRNA detection with laminar flow-assisted dendritic amplification (LFDA)
[3] on the pump-free microfluidic chip has been developed [4] In this study rapid and sensitive multiplex miRNA
detection on the pump-free microfluidic chip was demonstrated
Pump-free microchip for multiplex miRNA detection was prepared as follows First the PDMS part with a pair of
Y-shaped microchannels with 100 μm in width and 25 μm in height was fabricated Second three parallel-line-shaped
probe DNAs were patterned onto a glass surface Third the PDMS channels were attached onto the glass plate Finally
the chip was degassed in a vacuum chamber After the chip preparation target miRNAs were detected following three
steps (1) blocking (2) sandwich hybridization of the target miRNAs and biotinylated probe DNAs and (3) signal
amplification by LFDA MiR-16 miR-21-5p and miR-500a-3p were used as target miRNAs since they are known as
cancer biomarkers [5-7] Fluorescence signals were captured by CCD camera and analyzed by the software (ImageJ)
Bright lines appeared at the expected positions they appeared only on the areas with the respective probe DNA in which
the target miRNAs had been supplied These data prove that the LFDA successfully took place in a target
sequence-dependent manner Calibration curves were plotted from the fluorescence signals The data points of the
calibration curve were fitted with the four-parameter logistic function and limit-of-detections (LODs) were evaluated by
the 3σ criterion LODs of the miR-16 miR-21-5p and miR-500a-3p were 68 fM 15 pM and 150 fM respectively The
LODs are on the same order of magnitude as concentrations of miRNA in blood Multiplex detection was verified from
correspondence between the calibration curves of single and multiplex The required sample volume was 05 microL and
assay time was 20 min Because most of the existing methods take more than a few hours the rapidness small required
sample volume and portability of the device are ideal advantages for POC diagnosis
References
[1] PS Mitchell et al PNAS 105 (2008) 10513 [2] K Hosokawa et al Lab Chip 4 (2004) 181 [3] K Hosokawa et al Anal
Chem 79 (2007) 6000 [4] H Arata et al PLoS ONE 7 (2012) e48329 [5] MJ Lodes et al PLoS ONE 4 (2009) e6229
[6] Y Toiyama et al J Natl Cancer Inst 105 (2013) 849 [7] Y Yamamoto et al Biomarkers 14 (2009) 529
19
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-5 Dr Wen-Hsuan Chiang
Assistant Researcher
Department of Biomedical Engineering and Environmental Sciences
National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
TEL (886) 3-571-5131 ext 35576
Education 2009 PhD Department of Chemical Engineering National Chung Hsing University Taiwan Thesis Supervisor Professor Hsin-Cheng Chiu 2002 BS Department of Chemical Engineering Tatung University Taiwan Professional Experience 2013 ndashpresent Assistant Researcher Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University 2010 ndash2012 Postdoctoral Fellow Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
Areas of Research Expertise Biomaterials Smart Amphiphilic Copolymers Multifunctional Nanocarriers for Cancer Therapy and Imaging Nano Science and Interfacial Engineering
Selected Publication (2010~) Wen-Hsuan Chiang Wen-Chia Huang Ming-Yin Shen Che-Hsu Wang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Dual-Layered Nanogel-Coated Hollow LipidPolypeptide Conjugate Assemblies for Potential pH-Triggered Intracellular Drug Release PLOS ONE 2014 9 1-11 Wen-Hsuan Chiang Wen-Chia Huang Chien-Wen Chang Ming-Yin Shen Zong-Fu Shih Yi-Fong Huang Sung-Chyr Lin Hsin-Cheng Chiu Functionalized Polymersomes with Outlayered Polyelectrolyte Gels for Potential Tumor-Targeted Delivery of Multimodal Therapies and MR Imaging Journal of Controlled Release 2013 168 280-288 Wen-Hsuan Chiang Viet Thang Ho Hsin-Hung Chen Wen-Chia Huang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Superparamagnetic Hollow Hybrid Nanogels as a Potential Guidable Vehicle System of Stimuli-Mediated MR Imaging and Multiple Cancer Therapeutics Langmuir 2013 29 6434-6443 Wen-Hsuan Chiang Viet Thang Ho Wen-Chia Huang Yi-Fong Huang Chorng-Shyan Chern Hsin-Cheng Chiu Dual Stimuli-Responsive Polymeric Hollow Nanogels Designed as Carriers for Intracellular Triggered Drug Release Langmuir 2012 28 15056-15064 Yi-Fong HuangDagger Wen-Hsuan ChiangDagger Pei-Ling Tsai Chorng-Shyan Chern Hsin-Cheng Chiu Novel Hybrid Vesicles Co-Assembled from Cationic Lipid and PAAc-g-mPEG with pH-Triggered Transmembrane Channels for Controlled Drug Release Chemical Communications 2011 47 10978-10980
20
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-5 Sep 13 2014 (Sat) 1140-1210 at NTHU BMES R120 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and Imaging
Applications
Wen-Hsuan Chiang
Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
In order to promote therapeutic efficacy and minimize side effect equipping these nanocarriers with the
capability of controlling drug release in response to an appropriate stimulus is essentially required Acidic pH
as an internal stimulus is particular appealing because of the mildly acid pH encountered in tumor tissues and
the intracellular compartments such as endosomes and lysosomes Therefore the pH-responsive drug carriers
have been extensively developed for improving intracellular drug delivery To realize the pH-responsive drug
release we adopted a simple approach to design the lipidPEG-containing complex vesicles with pH-triggered
transmembrane channels as a chemotherapy drug doxorubicin (DOX) delivery carrier In this study the
complex vesicles were attained by spontaneous co-assembly of poly(acrylic acid)-g-poly(monomethoxy
ethylene glycol) (PAAc-g-mPEG) with a cationic lipid didodecyldimethylammonium bromide (DDAB) in
aqueous phase of pH 89 via electrostatic interactions Through the formation of unionized AAc-rich
transmembrance channels of complex vesicles in weak acidic environments the acid-triggered rapid drug
release can be achieved
On the other hand for simultaneously monitoring disease progression and biological response after
treatments we developed a novel tumor-targeting polymersome system capable of delivering magnetic
resonance imaging (MRI) and chemotherapy The DOX-loaded magnetic polymersomes were first attained by
the self-assembly of lipid-containing copolymer poly(AAc-co-distearin acrylate) in aqueous solution
containing citric acid-coated superparamagnetic iron oxide nanoparticles (SPIONs) and followed by DOX
loading via electrostatic attraction To further functionalize these vesicles with superior in vivo colloidal
stability pH-tunable drug release and active tumor-targeting chitosan and poly( -glutamic
acid-co- -glutamyl oxysuccinimide)-g-PEG-folate (FA) were deposited in sequence onto the assembly outer
surfaces The interfacial nanogel layers via electrostatic interactions and in-situ covalent cross-linking were
thus produced Triggerable release of the encapsulated DOX was governed by dual external stimuli pH and
temperature When these theranostic NCPs were effectively internalized by HeLa cells via FA
receptor-mediated endocytosis and then exposed to high frequency magnetic fields (HFMF) the combined
effects of both pH and magnetic hyperthermia-triggered drug release and thermo-therapy resulted in greater
cytotoxicity than the treatment by DOX alone By virtue of the SPION clustering effect in the assembly inner
aqueous compartments the SPIONDOX-loaded NCPs displayed an r2 relaxivity value higher than Resovist
a commercial SPION-based T2 contrast agent The high magnetic relaxivity of the tumor-targeting NCPs
coupled with their enhanced cellular uptake considerably promoted the MRI contrast of targeted cancer cells
These results demonstrate the great potential of the FA-decorated SPIONDOX-loaded NCPs as an advanced
cancer theranostic nanodevice
21
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-1 Prof Hao-Li Liu Professor and Director
Department of Electrical Engineering
Chang Gung University
Phone +886-3-2118800 ext 5677
Fax +886-3-2118026
E-mail haoliliumailcguedutw
Education 2003 PhD National Taiwan University Taipei TAIWAN 1998 M S National Taiwan University Taipei TAIWAN 1996 B S National Taipei University of Technology TAIWAN
Professional Experience 2012-present Director Dept of Electrical Engineering Chang Gung Univ Taiwan 2011-present Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2008 Associate Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2005 ndash2008 Assistant Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2004 ndash2005 Research Fellow Department of Radiology Brigham amp Womenrsquos Hospital Harvard Medical School MA USA
Honor and awards (2009~) 2013 Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) 2013 The 2013 Frederick Lizzi Award International Society of Therapeutic Ultrasound 2011 Distinguished Tech-Coop Award (長庚大學優良教師技合獎) Chang-Gung University 2011 Wu Ta-You Memorial Award (吳大猷先生紀念獎) National Science Council Taiwan 2011 2010 Distinguished Research Award (長庚大學優良教師研究獎) Chang-Gung University
Selected Publication (2010~) HW Yang MY Hua TL Hwang KJ Lin CY Huang RY Tsai CCM Ma PH Hsu SP Wey PW Hsu PY Chen YC Huang YJ Lu TC Yen LY Feng CW Lin HL Liu KC Wei Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide Advanced Materials Vol 25 No 26 pp3605-3611 2013 HL Liu CH Fan CY Ting and CK Yeh Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors Theranostics Vol 4 No 4 pp432-444 2014 KC Wei PC Chu HYJ Wang CY Huang PY Chen HC Tsai YJ Lu IC Tseng PY Lee TC Yen and HL Liu Focused Ultrasound-induced BloodndashBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment A Preclinical Study PLoS ONE Vol 8 No 3 pp e58995 2013 P-H Hsu K-C Wei C-Y Huang C-J Wen T-C Yen C-L Liu Y-T Lin J-C Chen C-R Shen and H-L Liu Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound PLoS ONE Vol 8 No 2 pp e57682 2013 H-L Liu M-Y Hua H-W Yang C-Y Huang P-C Chu J-S Wua I-C Tseng J-J Wang T-C Yen P-Y Chen and K-C Wei ldquoMagnetic resonance monitoring of focused ultrasoundmagnetic nanoparticle targeting delivery of therapeutic agents to the brainrdquo Proceedings of National Academy of Science USA Vol 107 No 34 pp15205-15210 2010 H-L Liu M-Y Hua P-Y Chen P-C Chu C-H Pan H-W Yang C-Y Huang J-J Wang T-C Yen and K-C Wei ldquoBloodndashBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatmentrdquo Radiology Vol 255 No 2 pp 415-425 2010 H-L Liu Y-Y Wai P-H Hsu L-A Lyu J-S Wu C-R Shen J-C Chen T-C Yen and J-J Wang ldquoIn Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Bloodndashbrain Barrier with Focused Ultrasound A Magnetic Resonance Imaging Studyrdquo Journal of Cerebral Blood Flow amp Metabolism Vol 30 pp 168-177 2010
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
11
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker
Invited Speaker A-1 Prof Yung Chang
Distinguished Professor
Department of Chemical Engineering
Deputy Director RampD Center for Membrane Technology
Chung Yuan Christian University
Address Jhong-Li Taoyuan 320 Taiwan
TEL (886) 265-4122
FAX (886) 265-4190
Education 2004 PhD Chemical Engineering National Taiwan University Taiwan 2000 MS Chemical Engineering National Taiwan University Taiwan 1998 BS Chemical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013-present Deputy Director RampD Center for Membrane Technology Chung Yuan Christian
University 2013-present Distinguished Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2013-present Professor Department of Chemical Engineering Chung Yuan Christian University
Taiwan 2009-2013 Associate Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2006-2009 Assistant Professor Department of Chemical Engineering Chung Yuan Christian
University Taiwan 2005-2006 Postdoctoral Fellow Chemical Engineering University of Washington USA 2004-2005 Postdoctoral Fellow Chemical Engineering National Taiwan University Taiwan
Honor and awards (2010~) 2010 Yung Investigator Award of Chemical Engineering (Taiwan Institute of Chemical Engineers) 2010 Yung Investigator Award of Materials on Regenerative Medicine (National Health Research
Institutes Taiwan) 2011 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan) 2011 Outstanding Research Award of Chemical Engineering (LCY Chemical Corp) 2012 NSC Wu Da-Yu Award (National science council Taiwan) 2012 NSC Outstanding AcademicIndustrial Cooperation Award (National science council) 2013 Yung Investigator Award of Polymer Science (Taiwan Institute of Polymer Science) 2013 JCS The Distinguished Lectureship Award Biomaterial Research (Japan Chemical Society) 2013 Ukraine International Invention Exhibition Gold Medal (Ukraine Invention Society) 2014 Pittsburgh International Invention Exhibition Gold Medal (USA Invention Society) 2014 Outstanding Research Professor Award (Chung Yuan Christian University Taiwan)
12
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-1 Sep 13 2014 (Sat) 0915-0945 at NTHU BMES R120
Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes
Chung Yuan
RampD Center for Membrane Technology and Department of Chemical Engineering Christian
University Chung-Li Taoyuan 320 Taiwan
Zwitterionic polymeric interface resisting the adsorption of plasma proteins is important in the
development of blood-contacting biomaterials in such applications as blood collection devices
antithrombogenic implants hemodialysis membranes drug-delivery carriers and diagnostic
biosensors Previous studies showed that the control of surface charge neutrality is important for a
zwitterionic surface with effective protein-resistant properties Importantly it was further reported
that the mixed-charge formulation in self-assembled monolayers copolymer hydrogels and
polymeric brushes provide a new avenue to achieve nonfouling surfaces with the prevention of
nonspecific protein adsorption if the charge balance can be well controlled This talk will cover three
major studies
Bio-inert nature of biomimetic zwitterionicpseudozwitterionic structures
Blood-Inert
Surfaces via ion-pair anchoring of zwitterionic copolymer brushes in human whole blood Surface
zwitterionization of membrenaes in novel biomedical applications
[1] Chang Y Liao SC Higuchi A Ruaan RC Chu CW Chen WY A highly stable nonbiofouling surface with
well-packed grafted zwitterionic polysulfobetaine for plasma protein repulsion Langmuir 2008245453-58
[2] Chiag YC Chang Y Higuchi A Chen WY Ruaan RC Sulfobetaine-grafted poly(vinylidene fluroride) ultrafiltration
membranes exhibit excellent antifouling property Journal of Membrane Science 2009339151-9
[3] Chang Y Yandi W Chen WY Shih YJ Yang CC Chang Y Ling QD Higuchi A Tunable bioadhesive copolymer
hydrogels of thermoresponsive poly(N-isopropyl acrylamide) containing zwitterionic polysulfobetaine
Biomacromolecules 2010111101-10
[4] Chang Y Chang WJ Shih YJ Wei TC Hsiue GH Zwitterionic sulfobetaine-grafted poly(vinylidene fluoride)
membrane with improved blood compatibility via atmospheric plasma-induced surface copolymerization ACS Appl
Mater Interfaces 201131228-37
[5] Shih YJ Chang Y Deratani A Damien Q Schizophrenic hemocompatible copolymers via switchable
thermoresponsive transition of nonioniczwitterionic block self-assembly in human blood Biomacromolecules
2012132849minus58
[6] Chang Y Shih YJ Lai CJ Kung HH Jiang S Ion-pair anchoring of self-assembled zwitterionic copolymer surfaces
with highly controlled blood compatibility Advanced Functional Materials 2013231100-10
13
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-2 Dr Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences
University of Tsukuba
Address Tennoudai 1-1-1 Tsukuba Ibaraki 305-8573 Japan
E-mailikedaimstsukubaacjp
Education March 1999 B S in Faculty of Engineering Kyoto University March 2001 MS in Graduate School of Engineering Department of Synthetic Chemistry and
Biological Chemistry Kyoto University March 2004 PhD in School of Engineering The University of Tokyo
Professional Experience 2004~2006 Advanced industrial science and technology (AIST) 2006~2008 Cytopathfinder Inc 2008~to date University of Tsukuba
Selected Publication (2010~) Y Ikeda J Katamachi H Kawasaki Y Nagasaki Novel protein PEGylation chemistry via glutalaldehydefunctionalized PEG Bioconjugate Chemistry 24 1824-1827 (2013) Y Ikeda D Kubota Y Nagasaki Design of sugar-oligonucleotide conjugates installed gold nanoparticle for effective delivery to hepatic parenchymal cells Colloid and Polymer Science 291 2959-2964 Y Ikeda H Kawasaki S Ichinohe Y Nagasaki Facile solid-phase synthesis of a highly stable poly(ethylene glycol)-oligonucleotide conjugate Journal of Materials Chemistry B 1 529-535(2013) Y Ikeda T Jomura U Horiuchi J Saeki K Yoshimoto T Ikeya Y Nagasaki Long-term survival and functional maintenance of hepatocytes by using a microfabricated cell array Colloid and Surface B Biointerface 97 97-100 2012 Y Ikeda Y Nagasaki PEGylation Technology in Nanomedicine Advances in Polymer Science 247 115-140 2012 Y Ikeda R Suzuki T Yoshitomi Y Nagasaki Novel oligonucleotide carrier possessing reactive oxygen species scavenging ability Macromolecular Bioscience 2011 11 344-351 Y Ikeda D Kubota Y Nagasaki Simple solid-phase synthesis and biological properties of carbohydrate-oligonucleotide conjugates modified at the 3rsquo terminus Bioconjugate Chem 2010 21 1685-1690
14
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-2 Sep 13 2014 (Sat) 0945-1015 at NTHU BMES R120
Chemical Modifications for the Developments of Next Generation Drugs
Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences University of
Tsukuba
Controlling of biodistribution and PKPD is a key issue for the development of drugsVariety of
technologies have been reported to improve those properties Those technologies include
nanoparticle formulation and PEGylation technology In my presentation I will show recent
chemical modification technologies which we developed to improve PKPD and distribution of
drugs
A novel chemistry for the PEGylated protein with a high activity
Several PEGylated proteins have been approved as therapeutic drugs In many cases PEGylated
protein has been synthesized by the conjugation reaction between PEG possessing activated ester and
amine(s) in the protein This reaction however often causes inactivation of PEGylated proteins In
this report we present a novel chemistry which enables the PEGylation of proteins under the mild
reaction condition PEGylated lysozyme prepared by the method developed increased the biological
activity of the PEGylated lysozyme more than 20 times compared with the PEGylated lysozyme
prepared by the conventional method
Design and development of novel hypoxically activated prodrugs
Tumor hypoxia is well known to promote mutagenesis invasiveness and to be associated with a
worse prognosis Although the treatment of the tumor hypoxia has been highly demanded resistance
to radiotherapy and anticancer chemotherapy have been serious problems The object of this study
was the development of hypoxically activated prodrugs which accumulate and act on cells at hypoxic
region of tumor Several conventional anti-cancer drugs including doxorubicin gemcitabine and 5FU
have been modified with 2-nitro imidazole derivative This modification enabled inactivation of drug
to reduce adverse effects under the normoxia condition and selective activation of prodrug under the
hypoxic condition
15
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-3 Prof Tzu-Wei Wang
Associate Professor
Department of Materials Science and Engineering and Institute of Biomedical
Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013
Office Delta Teaching Building R434
TEL +886-3-5715131 ext 33856
Email twwangmxnthuedutw Education 2006 PhD Institute of Biomedical Engineering National Taiwan University Taiwan
Professional Experience 2013 ndashpresent Associate Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2009 -2013 Assistant Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2007-2009 Postdoctoral Research Fellow Tissue Engineering Laboratories of Brigham and Womenrsquos
Hospital Harvard Medical School USA
Honor and awards (2009~) Young Plenary Award 2013 TERMIS-AP Symposium Shanghai China (2013) The 9th National Innovation Award Academic Research Category by Institute for Biotechnology and Medicine Industry Taiwan (2012) Young Investigator Award International Symposium of Materials on Regenerative Medicine Taiwan (2012 ISOMRM) Young Investigator Award 5th World Congress on Bioengineering the World Association for Chinese Biomedical Engineers Taiwan (WACBE 2011)
Selected Publication (2012~) Yang CS Wu HC Sun JS Hsiao HM Wang TW Thermo-induced shape memory PEG-PCL copolymer as dual drug-eluting biodegradable stent ACS Appl Mater Interfaces 2013 5 (21) 10985ndash10994 Yeh PH Sun JS Wu HC Hwang LH Wang TW Stimuli-responsive HA-PEI nanoparticles encapsulating endostatin plasmid for stem cell gene therapy RSC Advances 2013 3 (31) 12922 - 12932 Chen YY Wu HC Sun JS Dong GC Wang TW Injectable and thermoresponsive self-assembled nanocomposite hydrogel for long-term anticancer drug delivery Langmuir 201329(11)3721-3729 Cheng TY Wu HC Chang WH Huang MY Lee CH Wang TW Self-assembling functionalized nanopeptides for immediate hemostasis and accelerative liver tissue regeneration Nanoscale 2013 5 (7) 2734 - 2744 Chang YJ Tsai CJ Tseng FG Chen TJ Wang TW Micropatterned Stretching System for the Investigation of Mechanical Tension on Neural Stem Cells Behavior Nanomedicine Nanotechnology Biology and Medicine 20139345-355 Cheng TY Chen MH Chang WH Huang MY Wang TW Neural stem cells encapsulated in a functionalized self-assembling peptide hydrogel for brain tissue engineering Biomaterials 2013 34(8)2005-2016 Goh JH Wu HC Chen MH Chen MY Chang SC Wang TW Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages Acta Biomaterialia 20139(2)5170-5180 Huang YJ Wu HC Tai NH Wang TW Carbon Nanotube Rope with Electrical Stimulation Promotes the Differentiation and Maturity of Neural Stem Cells Small 20128(18) 2869ndash2877
16
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-3 Sep 13 2014 (Sat) 1015-1045 at NTHU BMES R120
Electrospun Composite Nanofibers with Staged Release of Multiple Angiogenic Growth Factors for Chronic Wound Healing
Tzu-Wei Wang
Department of Materials Science and Engineering and Institute of Biomedical Engineering National
Tsing Hua University
The objective of this research study is to develop collagen (Col) and hyaluronic acid (HA)
inter-stacking nanofibrous skin equivalent substitute with programmable release of multiple
angiogenic growth factors (VEGF PDGF bFGF and EGF) either directly embedded in the
nanofibers or encapsulated in the gelatin nanoparticles (GN) by electrospinning technology The
delivery of EGF and bFGF in early stage is expected to accelerate epithelialization and vasculature
sprouting while release of PDGF and VEGF in late stage is aimed for the induction of blood vessels
maturation The physiochemical characterizations report that the Col-HA-GN nanofibrous membrane
possesses mechanical property similar to human native skin The design of particle-in-fiber structure
allows growth factors for slow controlled release up to one month Cultured on biodegradable
Col-HA membrane with four kinds of growth factors (Col-HA w4GF) endothelial cells not only
increase in growth rate but also form better network of thread-like tubular structure Therapeutic
effect of Col-HA w4GF membrane on STZ-induced diabetic rats reveal accelerated wound closure
rate elevated collagen deposition and enhanced mature vessels by Massonrsquos trichrome stain and
immunohistochemical analysis respectively From the above the electrospun Col-HA-GN composite
nanofibrous skin substitute with stage-wise release pattern of multiple angiogenic factors could be a
promising bioengineered construct for the chronic wound healing in skin tissue regeneration
17
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-4 Assistant Prof Ryo Ishihara
Assistant Professor
Department of Materials Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
Tokyo University of Science Research Building 9th floor
TEL +81-3-5876-1415
FAX +81-3-5876-1415
Education 2012 PhD Department of Applied Chemistry and Biotechnology Chiba University Japan 2008 MS Department of Materials Technology Chiba University Japan 2006 BS Department of Materials Technology Chiba University Japan
Professional Experience 2014 ndashpresent Assistant Professor Department of Materials Science and Technology Tokyo
University of Science 2012 ndash2014 Postdoctral Researcher Bioengineering Laboratory RIKEN
Honor and awards Department chairmanlsquos award from Chiba University (2012)
Selected Publication (2010~) Simple Method for High-Density Impregnation of Aliquat 336 onto Porous Sheet and Binding Performance of Resulting Sheet for Palladium Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota Sep Sci Technol 49154-159 (2014) Effect of Dose on Mole Percentage of Polymer Brush and Root Grafted onto Porous Polyethylene Sheet by Radiation-Induced Graft Polymerization R Ishihara S Uchiyama H Ikezawa S Yamada H Hirota D Umeno K Saito Ind Eng Chem Res 5212582-12586 (2013) Determination of Mole Percentages of Brush and Root of Polymer Chain Grafted onto Porous Sheet S Uchiyama R Ishihara D Umeno K Saito S Yamada H Hirota S Asai J Chem Eng Japan 46414-419 (2013) Crosslinked-chelating Porous Sheet with High Dynamic Binding Capacity of Metal Ions G Wada R Ishihara K Miyoshi D Umeno K Saito S Yamada H Hirota Solv Extr Ion Exch 31210-220 (2013) Dependence of Lanthanide-Ion Binding Performance on HDEHP Concentration in HDEHP Impregnation to Porous Sheet R Ishihara S Asai S Otosaka S Yamada H Hirota K Miyoshi D Umeno K Saito Solv Extr Ion Exch 30171-180 (2012) Impregnation of TOPO onto Hydrophobic-Ligand-Containing Porous Sheet and Its Adsorptionelution Performance of Bismuth Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota React Funct Polym 70986-990 (2010)
18
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-4 Sep 13 2014 (Sat) 1110-1140 at NTHU BMES R120
Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip toward Point-of-Care Diagnosis
Ryo Ishihara Kazuo Hosokawa Mizuo Maeda
Bioengineering Laboratory RIKEN
MicroRNAs (miRNAs) are short and non-protein-coding single-stranded RNAs and have shown great promise for
cancer diagnosis Some miRNAs circulate in human body fluid with extremely low concentrations and its expression
profiling can detect and classify cancers in the human body [1] Point-of-care (POC) diagnosis requires short detection
time small required sample volume and portability of the device In various miRNA detection methods microfluidic
chip meets the requirements except the portability Hence we used our power-free pump-free microfluidic chip driven
by energy that is stored in degased PDMS to overcome those drawbacks which eliminates the need for external power
sources for fluid pumping [2] The pump-free pumping method is essential for microfluidic chip-based POC diagnosis In
our laboratory rapid and sensitive singleplex miRNA detection with laminar flow-assisted dendritic amplification (LFDA)
[3] on the pump-free microfluidic chip has been developed [4] In this study rapid and sensitive multiplex miRNA
detection on the pump-free microfluidic chip was demonstrated
Pump-free microchip for multiplex miRNA detection was prepared as follows First the PDMS part with a pair of
Y-shaped microchannels with 100 μm in width and 25 μm in height was fabricated Second three parallel-line-shaped
probe DNAs were patterned onto a glass surface Third the PDMS channels were attached onto the glass plate Finally
the chip was degassed in a vacuum chamber After the chip preparation target miRNAs were detected following three
steps (1) blocking (2) sandwich hybridization of the target miRNAs and biotinylated probe DNAs and (3) signal
amplification by LFDA MiR-16 miR-21-5p and miR-500a-3p were used as target miRNAs since they are known as
cancer biomarkers [5-7] Fluorescence signals were captured by CCD camera and analyzed by the software (ImageJ)
Bright lines appeared at the expected positions they appeared only on the areas with the respective probe DNA in which
the target miRNAs had been supplied These data prove that the LFDA successfully took place in a target
sequence-dependent manner Calibration curves were plotted from the fluorescence signals The data points of the
calibration curve were fitted with the four-parameter logistic function and limit-of-detections (LODs) were evaluated by
the 3σ criterion LODs of the miR-16 miR-21-5p and miR-500a-3p were 68 fM 15 pM and 150 fM respectively The
LODs are on the same order of magnitude as concentrations of miRNA in blood Multiplex detection was verified from
correspondence between the calibration curves of single and multiplex The required sample volume was 05 microL and
assay time was 20 min Because most of the existing methods take more than a few hours the rapidness small required
sample volume and portability of the device are ideal advantages for POC diagnosis
References
[1] PS Mitchell et al PNAS 105 (2008) 10513 [2] K Hosokawa et al Lab Chip 4 (2004) 181 [3] K Hosokawa et al Anal
Chem 79 (2007) 6000 [4] H Arata et al PLoS ONE 7 (2012) e48329 [5] MJ Lodes et al PLoS ONE 4 (2009) e6229
[6] Y Toiyama et al J Natl Cancer Inst 105 (2013) 849 [7] Y Yamamoto et al Biomarkers 14 (2009) 529
19
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-5 Dr Wen-Hsuan Chiang
Assistant Researcher
Department of Biomedical Engineering and Environmental Sciences
National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
TEL (886) 3-571-5131 ext 35576
Education 2009 PhD Department of Chemical Engineering National Chung Hsing University Taiwan Thesis Supervisor Professor Hsin-Cheng Chiu 2002 BS Department of Chemical Engineering Tatung University Taiwan Professional Experience 2013 ndashpresent Assistant Researcher Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University 2010 ndash2012 Postdoctoral Fellow Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
Areas of Research Expertise Biomaterials Smart Amphiphilic Copolymers Multifunctional Nanocarriers for Cancer Therapy and Imaging Nano Science and Interfacial Engineering
Selected Publication (2010~) Wen-Hsuan Chiang Wen-Chia Huang Ming-Yin Shen Che-Hsu Wang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Dual-Layered Nanogel-Coated Hollow LipidPolypeptide Conjugate Assemblies for Potential pH-Triggered Intracellular Drug Release PLOS ONE 2014 9 1-11 Wen-Hsuan Chiang Wen-Chia Huang Chien-Wen Chang Ming-Yin Shen Zong-Fu Shih Yi-Fong Huang Sung-Chyr Lin Hsin-Cheng Chiu Functionalized Polymersomes with Outlayered Polyelectrolyte Gels for Potential Tumor-Targeted Delivery of Multimodal Therapies and MR Imaging Journal of Controlled Release 2013 168 280-288 Wen-Hsuan Chiang Viet Thang Ho Hsin-Hung Chen Wen-Chia Huang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Superparamagnetic Hollow Hybrid Nanogels as a Potential Guidable Vehicle System of Stimuli-Mediated MR Imaging and Multiple Cancer Therapeutics Langmuir 2013 29 6434-6443 Wen-Hsuan Chiang Viet Thang Ho Wen-Chia Huang Yi-Fong Huang Chorng-Shyan Chern Hsin-Cheng Chiu Dual Stimuli-Responsive Polymeric Hollow Nanogels Designed as Carriers for Intracellular Triggered Drug Release Langmuir 2012 28 15056-15064 Yi-Fong HuangDagger Wen-Hsuan ChiangDagger Pei-Ling Tsai Chorng-Shyan Chern Hsin-Cheng Chiu Novel Hybrid Vesicles Co-Assembled from Cationic Lipid and PAAc-g-mPEG with pH-Triggered Transmembrane Channels for Controlled Drug Release Chemical Communications 2011 47 10978-10980
20
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-5 Sep 13 2014 (Sat) 1140-1210 at NTHU BMES R120 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and Imaging
Applications
Wen-Hsuan Chiang
Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
In order to promote therapeutic efficacy and minimize side effect equipping these nanocarriers with the
capability of controlling drug release in response to an appropriate stimulus is essentially required Acidic pH
as an internal stimulus is particular appealing because of the mildly acid pH encountered in tumor tissues and
the intracellular compartments such as endosomes and lysosomes Therefore the pH-responsive drug carriers
have been extensively developed for improving intracellular drug delivery To realize the pH-responsive drug
release we adopted a simple approach to design the lipidPEG-containing complex vesicles with pH-triggered
transmembrane channels as a chemotherapy drug doxorubicin (DOX) delivery carrier In this study the
complex vesicles were attained by spontaneous co-assembly of poly(acrylic acid)-g-poly(monomethoxy
ethylene glycol) (PAAc-g-mPEG) with a cationic lipid didodecyldimethylammonium bromide (DDAB) in
aqueous phase of pH 89 via electrostatic interactions Through the formation of unionized AAc-rich
transmembrance channels of complex vesicles in weak acidic environments the acid-triggered rapid drug
release can be achieved
On the other hand for simultaneously monitoring disease progression and biological response after
treatments we developed a novel tumor-targeting polymersome system capable of delivering magnetic
resonance imaging (MRI) and chemotherapy The DOX-loaded magnetic polymersomes were first attained by
the self-assembly of lipid-containing copolymer poly(AAc-co-distearin acrylate) in aqueous solution
containing citric acid-coated superparamagnetic iron oxide nanoparticles (SPIONs) and followed by DOX
loading via electrostatic attraction To further functionalize these vesicles with superior in vivo colloidal
stability pH-tunable drug release and active tumor-targeting chitosan and poly( -glutamic
acid-co- -glutamyl oxysuccinimide)-g-PEG-folate (FA) were deposited in sequence onto the assembly outer
surfaces The interfacial nanogel layers via electrostatic interactions and in-situ covalent cross-linking were
thus produced Triggerable release of the encapsulated DOX was governed by dual external stimuli pH and
temperature When these theranostic NCPs were effectively internalized by HeLa cells via FA
receptor-mediated endocytosis and then exposed to high frequency magnetic fields (HFMF) the combined
effects of both pH and magnetic hyperthermia-triggered drug release and thermo-therapy resulted in greater
cytotoxicity than the treatment by DOX alone By virtue of the SPION clustering effect in the assembly inner
aqueous compartments the SPIONDOX-loaded NCPs displayed an r2 relaxivity value higher than Resovist
a commercial SPION-based T2 contrast agent The high magnetic relaxivity of the tumor-targeting NCPs
coupled with their enhanced cellular uptake considerably promoted the MRI contrast of targeted cancer cells
These results demonstrate the great potential of the FA-decorated SPIONDOX-loaded NCPs as an advanced
cancer theranostic nanodevice
21
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-1 Prof Hao-Li Liu Professor and Director
Department of Electrical Engineering
Chang Gung University
Phone +886-3-2118800 ext 5677
Fax +886-3-2118026
E-mail haoliliumailcguedutw
Education 2003 PhD National Taiwan University Taipei TAIWAN 1998 M S National Taiwan University Taipei TAIWAN 1996 B S National Taipei University of Technology TAIWAN
Professional Experience 2012-present Director Dept of Electrical Engineering Chang Gung Univ Taiwan 2011-present Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2008 Associate Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2005 ndash2008 Assistant Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2004 ndash2005 Research Fellow Department of Radiology Brigham amp Womenrsquos Hospital Harvard Medical School MA USA
Honor and awards (2009~) 2013 Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) 2013 The 2013 Frederick Lizzi Award International Society of Therapeutic Ultrasound 2011 Distinguished Tech-Coop Award (長庚大學優良教師技合獎) Chang-Gung University 2011 Wu Ta-You Memorial Award (吳大猷先生紀念獎) National Science Council Taiwan 2011 2010 Distinguished Research Award (長庚大學優良教師研究獎) Chang-Gung University
Selected Publication (2010~) HW Yang MY Hua TL Hwang KJ Lin CY Huang RY Tsai CCM Ma PH Hsu SP Wey PW Hsu PY Chen YC Huang YJ Lu TC Yen LY Feng CW Lin HL Liu KC Wei Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide Advanced Materials Vol 25 No 26 pp3605-3611 2013 HL Liu CH Fan CY Ting and CK Yeh Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors Theranostics Vol 4 No 4 pp432-444 2014 KC Wei PC Chu HYJ Wang CY Huang PY Chen HC Tsai YJ Lu IC Tseng PY Lee TC Yen and HL Liu Focused Ultrasound-induced BloodndashBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment A Preclinical Study PLoS ONE Vol 8 No 3 pp e58995 2013 P-H Hsu K-C Wei C-Y Huang C-J Wen T-C Yen C-L Liu Y-T Lin J-C Chen C-R Shen and H-L Liu Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound PLoS ONE Vol 8 No 2 pp e57682 2013 H-L Liu M-Y Hua H-W Yang C-Y Huang P-C Chu J-S Wua I-C Tseng J-J Wang T-C Yen P-Y Chen and K-C Wei ldquoMagnetic resonance monitoring of focused ultrasoundmagnetic nanoparticle targeting delivery of therapeutic agents to the brainrdquo Proceedings of National Academy of Science USA Vol 107 No 34 pp15205-15210 2010 H-L Liu M-Y Hua P-Y Chen P-C Chu C-H Pan H-W Yang C-Y Huang J-J Wang T-C Yen and K-C Wei ldquoBloodndashBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatmentrdquo Radiology Vol 255 No 2 pp 415-425 2010 H-L Liu Y-Y Wai P-H Hsu L-A Lyu J-S Wu C-R Shen J-C Chen T-C Yen and J-J Wang ldquoIn Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Bloodndashbrain Barrier with Focused Ultrasound A Magnetic Resonance Imaging Studyrdquo Journal of Cerebral Blood Flow amp Metabolism Vol 30 pp 168-177 2010
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
12
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-1 Sep 13 2014 (Sat) 0915-0945 at NTHU BMES R120
Blood-inert Nature of Zwitterionic Polymeric Interface and Membranes
Chung Yuan
RampD Center for Membrane Technology and Department of Chemical Engineering Christian
University Chung-Li Taoyuan 320 Taiwan
Zwitterionic polymeric interface resisting the adsorption of plasma proteins is important in the
development of blood-contacting biomaterials in such applications as blood collection devices
antithrombogenic implants hemodialysis membranes drug-delivery carriers and diagnostic
biosensors Previous studies showed that the control of surface charge neutrality is important for a
zwitterionic surface with effective protein-resistant properties Importantly it was further reported
that the mixed-charge formulation in self-assembled monolayers copolymer hydrogels and
polymeric brushes provide a new avenue to achieve nonfouling surfaces with the prevention of
nonspecific protein adsorption if the charge balance can be well controlled This talk will cover three
major studies
Bio-inert nature of biomimetic zwitterionicpseudozwitterionic structures
Blood-Inert
Surfaces via ion-pair anchoring of zwitterionic copolymer brushes in human whole blood Surface
zwitterionization of membrenaes in novel biomedical applications
[1] Chang Y Liao SC Higuchi A Ruaan RC Chu CW Chen WY A highly stable nonbiofouling surface with
well-packed grafted zwitterionic polysulfobetaine for plasma protein repulsion Langmuir 2008245453-58
[2] Chiag YC Chang Y Higuchi A Chen WY Ruaan RC Sulfobetaine-grafted poly(vinylidene fluroride) ultrafiltration
membranes exhibit excellent antifouling property Journal of Membrane Science 2009339151-9
[3] Chang Y Yandi W Chen WY Shih YJ Yang CC Chang Y Ling QD Higuchi A Tunable bioadhesive copolymer
hydrogels of thermoresponsive poly(N-isopropyl acrylamide) containing zwitterionic polysulfobetaine
Biomacromolecules 2010111101-10
[4] Chang Y Chang WJ Shih YJ Wei TC Hsiue GH Zwitterionic sulfobetaine-grafted poly(vinylidene fluoride)
membrane with improved blood compatibility via atmospheric plasma-induced surface copolymerization ACS Appl
Mater Interfaces 201131228-37
[5] Shih YJ Chang Y Deratani A Damien Q Schizophrenic hemocompatible copolymers via switchable
thermoresponsive transition of nonioniczwitterionic block self-assembly in human blood Biomacromolecules
2012132849minus58
[6] Chang Y Shih YJ Lai CJ Kung HH Jiang S Ion-pair anchoring of self-assembled zwitterionic copolymer surfaces
with highly controlled blood compatibility Advanced Functional Materials 2013231100-10
13
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-2 Dr Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences
University of Tsukuba
Address Tennoudai 1-1-1 Tsukuba Ibaraki 305-8573 Japan
E-mailikedaimstsukubaacjp
Education March 1999 B S in Faculty of Engineering Kyoto University March 2001 MS in Graduate School of Engineering Department of Synthetic Chemistry and
Biological Chemistry Kyoto University March 2004 PhD in School of Engineering The University of Tokyo
Professional Experience 2004~2006 Advanced industrial science and technology (AIST) 2006~2008 Cytopathfinder Inc 2008~to date University of Tsukuba
Selected Publication (2010~) Y Ikeda J Katamachi H Kawasaki Y Nagasaki Novel protein PEGylation chemistry via glutalaldehydefunctionalized PEG Bioconjugate Chemistry 24 1824-1827 (2013) Y Ikeda D Kubota Y Nagasaki Design of sugar-oligonucleotide conjugates installed gold nanoparticle for effective delivery to hepatic parenchymal cells Colloid and Polymer Science 291 2959-2964 Y Ikeda H Kawasaki S Ichinohe Y Nagasaki Facile solid-phase synthesis of a highly stable poly(ethylene glycol)-oligonucleotide conjugate Journal of Materials Chemistry B 1 529-535(2013) Y Ikeda T Jomura U Horiuchi J Saeki K Yoshimoto T Ikeya Y Nagasaki Long-term survival and functional maintenance of hepatocytes by using a microfabricated cell array Colloid and Surface B Biointerface 97 97-100 2012 Y Ikeda Y Nagasaki PEGylation Technology in Nanomedicine Advances in Polymer Science 247 115-140 2012 Y Ikeda R Suzuki T Yoshitomi Y Nagasaki Novel oligonucleotide carrier possessing reactive oxygen species scavenging ability Macromolecular Bioscience 2011 11 344-351 Y Ikeda D Kubota Y Nagasaki Simple solid-phase synthesis and biological properties of carbohydrate-oligonucleotide conjugates modified at the 3rsquo terminus Bioconjugate Chem 2010 21 1685-1690
14
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-2 Sep 13 2014 (Sat) 0945-1015 at NTHU BMES R120
Chemical Modifications for the Developments of Next Generation Drugs
Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences University of
Tsukuba
Controlling of biodistribution and PKPD is a key issue for the development of drugsVariety of
technologies have been reported to improve those properties Those technologies include
nanoparticle formulation and PEGylation technology In my presentation I will show recent
chemical modification technologies which we developed to improve PKPD and distribution of
drugs
A novel chemistry for the PEGylated protein with a high activity
Several PEGylated proteins have been approved as therapeutic drugs In many cases PEGylated
protein has been synthesized by the conjugation reaction between PEG possessing activated ester and
amine(s) in the protein This reaction however often causes inactivation of PEGylated proteins In
this report we present a novel chemistry which enables the PEGylation of proteins under the mild
reaction condition PEGylated lysozyme prepared by the method developed increased the biological
activity of the PEGylated lysozyme more than 20 times compared with the PEGylated lysozyme
prepared by the conventional method
Design and development of novel hypoxically activated prodrugs
Tumor hypoxia is well known to promote mutagenesis invasiveness and to be associated with a
worse prognosis Although the treatment of the tumor hypoxia has been highly demanded resistance
to radiotherapy and anticancer chemotherapy have been serious problems The object of this study
was the development of hypoxically activated prodrugs which accumulate and act on cells at hypoxic
region of tumor Several conventional anti-cancer drugs including doxorubicin gemcitabine and 5FU
have been modified with 2-nitro imidazole derivative This modification enabled inactivation of drug
to reduce adverse effects under the normoxia condition and selective activation of prodrug under the
hypoxic condition
15
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-3 Prof Tzu-Wei Wang
Associate Professor
Department of Materials Science and Engineering and Institute of Biomedical
Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013
Office Delta Teaching Building R434
TEL +886-3-5715131 ext 33856
Email twwangmxnthuedutw Education 2006 PhD Institute of Biomedical Engineering National Taiwan University Taiwan
Professional Experience 2013 ndashpresent Associate Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2009 -2013 Assistant Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2007-2009 Postdoctoral Research Fellow Tissue Engineering Laboratories of Brigham and Womenrsquos
Hospital Harvard Medical School USA
Honor and awards (2009~) Young Plenary Award 2013 TERMIS-AP Symposium Shanghai China (2013) The 9th National Innovation Award Academic Research Category by Institute for Biotechnology and Medicine Industry Taiwan (2012) Young Investigator Award International Symposium of Materials on Regenerative Medicine Taiwan (2012 ISOMRM) Young Investigator Award 5th World Congress on Bioengineering the World Association for Chinese Biomedical Engineers Taiwan (WACBE 2011)
Selected Publication (2012~) Yang CS Wu HC Sun JS Hsiao HM Wang TW Thermo-induced shape memory PEG-PCL copolymer as dual drug-eluting biodegradable stent ACS Appl Mater Interfaces 2013 5 (21) 10985ndash10994 Yeh PH Sun JS Wu HC Hwang LH Wang TW Stimuli-responsive HA-PEI nanoparticles encapsulating endostatin plasmid for stem cell gene therapy RSC Advances 2013 3 (31) 12922 - 12932 Chen YY Wu HC Sun JS Dong GC Wang TW Injectable and thermoresponsive self-assembled nanocomposite hydrogel for long-term anticancer drug delivery Langmuir 201329(11)3721-3729 Cheng TY Wu HC Chang WH Huang MY Lee CH Wang TW Self-assembling functionalized nanopeptides for immediate hemostasis and accelerative liver tissue regeneration Nanoscale 2013 5 (7) 2734 - 2744 Chang YJ Tsai CJ Tseng FG Chen TJ Wang TW Micropatterned Stretching System for the Investigation of Mechanical Tension on Neural Stem Cells Behavior Nanomedicine Nanotechnology Biology and Medicine 20139345-355 Cheng TY Chen MH Chang WH Huang MY Wang TW Neural stem cells encapsulated in a functionalized self-assembling peptide hydrogel for brain tissue engineering Biomaterials 2013 34(8)2005-2016 Goh JH Wu HC Chen MH Chen MY Chang SC Wang TW Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages Acta Biomaterialia 20139(2)5170-5180 Huang YJ Wu HC Tai NH Wang TW Carbon Nanotube Rope with Electrical Stimulation Promotes the Differentiation and Maturity of Neural Stem Cells Small 20128(18) 2869ndash2877
16
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-3 Sep 13 2014 (Sat) 1015-1045 at NTHU BMES R120
Electrospun Composite Nanofibers with Staged Release of Multiple Angiogenic Growth Factors for Chronic Wound Healing
Tzu-Wei Wang
Department of Materials Science and Engineering and Institute of Biomedical Engineering National
Tsing Hua University
The objective of this research study is to develop collagen (Col) and hyaluronic acid (HA)
inter-stacking nanofibrous skin equivalent substitute with programmable release of multiple
angiogenic growth factors (VEGF PDGF bFGF and EGF) either directly embedded in the
nanofibers or encapsulated in the gelatin nanoparticles (GN) by electrospinning technology The
delivery of EGF and bFGF in early stage is expected to accelerate epithelialization and vasculature
sprouting while release of PDGF and VEGF in late stage is aimed for the induction of blood vessels
maturation The physiochemical characterizations report that the Col-HA-GN nanofibrous membrane
possesses mechanical property similar to human native skin The design of particle-in-fiber structure
allows growth factors for slow controlled release up to one month Cultured on biodegradable
Col-HA membrane with four kinds of growth factors (Col-HA w4GF) endothelial cells not only
increase in growth rate but also form better network of thread-like tubular structure Therapeutic
effect of Col-HA w4GF membrane on STZ-induced diabetic rats reveal accelerated wound closure
rate elevated collagen deposition and enhanced mature vessels by Massonrsquos trichrome stain and
immunohistochemical analysis respectively From the above the electrospun Col-HA-GN composite
nanofibrous skin substitute with stage-wise release pattern of multiple angiogenic factors could be a
promising bioengineered construct for the chronic wound healing in skin tissue regeneration
17
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-4 Assistant Prof Ryo Ishihara
Assistant Professor
Department of Materials Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
Tokyo University of Science Research Building 9th floor
TEL +81-3-5876-1415
FAX +81-3-5876-1415
Education 2012 PhD Department of Applied Chemistry and Biotechnology Chiba University Japan 2008 MS Department of Materials Technology Chiba University Japan 2006 BS Department of Materials Technology Chiba University Japan
Professional Experience 2014 ndashpresent Assistant Professor Department of Materials Science and Technology Tokyo
University of Science 2012 ndash2014 Postdoctral Researcher Bioengineering Laboratory RIKEN
Honor and awards Department chairmanlsquos award from Chiba University (2012)
Selected Publication (2010~) Simple Method for High-Density Impregnation of Aliquat 336 onto Porous Sheet and Binding Performance of Resulting Sheet for Palladium Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota Sep Sci Technol 49154-159 (2014) Effect of Dose on Mole Percentage of Polymer Brush and Root Grafted onto Porous Polyethylene Sheet by Radiation-Induced Graft Polymerization R Ishihara S Uchiyama H Ikezawa S Yamada H Hirota D Umeno K Saito Ind Eng Chem Res 5212582-12586 (2013) Determination of Mole Percentages of Brush and Root of Polymer Chain Grafted onto Porous Sheet S Uchiyama R Ishihara D Umeno K Saito S Yamada H Hirota S Asai J Chem Eng Japan 46414-419 (2013) Crosslinked-chelating Porous Sheet with High Dynamic Binding Capacity of Metal Ions G Wada R Ishihara K Miyoshi D Umeno K Saito S Yamada H Hirota Solv Extr Ion Exch 31210-220 (2013) Dependence of Lanthanide-Ion Binding Performance on HDEHP Concentration in HDEHP Impregnation to Porous Sheet R Ishihara S Asai S Otosaka S Yamada H Hirota K Miyoshi D Umeno K Saito Solv Extr Ion Exch 30171-180 (2012) Impregnation of TOPO onto Hydrophobic-Ligand-Containing Porous Sheet and Its Adsorptionelution Performance of Bismuth Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota React Funct Polym 70986-990 (2010)
18
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-4 Sep 13 2014 (Sat) 1110-1140 at NTHU BMES R120
Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip toward Point-of-Care Diagnosis
Ryo Ishihara Kazuo Hosokawa Mizuo Maeda
Bioengineering Laboratory RIKEN
MicroRNAs (miRNAs) are short and non-protein-coding single-stranded RNAs and have shown great promise for
cancer diagnosis Some miRNAs circulate in human body fluid with extremely low concentrations and its expression
profiling can detect and classify cancers in the human body [1] Point-of-care (POC) diagnosis requires short detection
time small required sample volume and portability of the device In various miRNA detection methods microfluidic
chip meets the requirements except the portability Hence we used our power-free pump-free microfluidic chip driven
by energy that is stored in degased PDMS to overcome those drawbacks which eliminates the need for external power
sources for fluid pumping [2] The pump-free pumping method is essential for microfluidic chip-based POC diagnosis In
our laboratory rapid and sensitive singleplex miRNA detection with laminar flow-assisted dendritic amplification (LFDA)
[3] on the pump-free microfluidic chip has been developed [4] In this study rapid and sensitive multiplex miRNA
detection on the pump-free microfluidic chip was demonstrated
Pump-free microchip for multiplex miRNA detection was prepared as follows First the PDMS part with a pair of
Y-shaped microchannels with 100 μm in width and 25 μm in height was fabricated Second three parallel-line-shaped
probe DNAs were patterned onto a glass surface Third the PDMS channels were attached onto the glass plate Finally
the chip was degassed in a vacuum chamber After the chip preparation target miRNAs were detected following three
steps (1) blocking (2) sandwich hybridization of the target miRNAs and biotinylated probe DNAs and (3) signal
amplification by LFDA MiR-16 miR-21-5p and miR-500a-3p were used as target miRNAs since they are known as
cancer biomarkers [5-7] Fluorescence signals were captured by CCD camera and analyzed by the software (ImageJ)
Bright lines appeared at the expected positions they appeared only on the areas with the respective probe DNA in which
the target miRNAs had been supplied These data prove that the LFDA successfully took place in a target
sequence-dependent manner Calibration curves were plotted from the fluorescence signals The data points of the
calibration curve were fitted with the four-parameter logistic function and limit-of-detections (LODs) were evaluated by
the 3σ criterion LODs of the miR-16 miR-21-5p and miR-500a-3p were 68 fM 15 pM and 150 fM respectively The
LODs are on the same order of magnitude as concentrations of miRNA in blood Multiplex detection was verified from
correspondence between the calibration curves of single and multiplex The required sample volume was 05 microL and
assay time was 20 min Because most of the existing methods take more than a few hours the rapidness small required
sample volume and portability of the device are ideal advantages for POC diagnosis
References
[1] PS Mitchell et al PNAS 105 (2008) 10513 [2] K Hosokawa et al Lab Chip 4 (2004) 181 [3] K Hosokawa et al Anal
Chem 79 (2007) 6000 [4] H Arata et al PLoS ONE 7 (2012) e48329 [5] MJ Lodes et al PLoS ONE 4 (2009) e6229
[6] Y Toiyama et al J Natl Cancer Inst 105 (2013) 849 [7] Y Yamamoto et al Biomarkers 14 (2009) 529
19
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-5 Dr Wen-Hsuan Chiang
Assistant Researcher
Department of Biomedical Engineering and Environmental Sciences
National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
TEL (886) 3-571-5131 ext 35576
Education 2009 PhD Department of Chemical Engineering National Chung Hsing University Taiwan Thesis Supervisor Professor Hsin-Cheng Chiu 2002 BS Department of Chemical Engineering Tatung University Taiwan Professional Experience 2013 ndashpresent Assistant Researcher Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University 2010 ndash2012 Postdoctoral Fellow Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
Areas of Research Expertise Biomaterials Smart Amphiphilic Copolymers Multifunctional Nanocarriers for Cancer Therapy and Imaging Nano Science and Interfacial Engineering
Selected Publication (2010~) Wen-Hsuan Chiang Wen-Chia Huang Ming-Yin Shen Che-Hsu Wang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Dual-Layered Nanogel-Coated Hollow LipidPolypeptide Conjugate Assemblies for Potential pH-Triggered Intracellular Drug Release PLOS ONE 2014 9 1-11 Wen-Hsuan Chiang Wen-Chia Huang Chien-Wen Chang Ming-Yin Shen Zong-Fu Shih Yi-Fong Huang Sung-Chyr Lin Hsin-Cheng Chiu Functionalized Polymersomes with Outlayered Polyelectrolyte Gels for Potential Tumor-Targeted Delivery of Multimodal Therapies and MR Imaging Journal of Controlled Release 2013 168 280-288 Wen-Hsuan Chiang Viet Thang Ho Hsin-Hung Chen Wen-Chia Huang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Superparamagnetic Hollow Hybrid Nanogels as a Potential Guidable Vehicle System of Stimuli-Mediated MR Imaging and Multiple Cancer Therapeutics Langmuir 2013 29 6434-6443 Wen-Hsuan Chiang Viet Thang Ho Wen-Chia Huang Yi-Fong Huang Chorng-Shyan Chern Hsin-Cheng Chiu Dual Stimuli-Responsive Polymeric Hollow Nanogels Designed as Carriers for Intracellular Triggered Drug Release Langmuir 2012 28 15056-15064 Yi-Fong HuangDagger Wen-Hsuan ChiangDagger Pei-Ling Tsai Chorng-Shyan Chern Hsin-Cheng Chiu Novel Hybrid Vesicles Co-Assembled from Cationic Lipid and PAAc-g-mPEG with pH-Triggered Transmembrane Channels for Controlled Drug Release Chemical Communications 2011 47 10978-10980
20
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-5 Sep 13 2014 (Sat) 1140-1210 at NTHU BMES R120 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and Imaging
Applications
Wen-Hsuan Chiang
Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
In order to promote therapeutic efficacy and minimize side effect equipping these nanocarriers with the
capability of controlling drug release in response to an appropriate stimulus is essentially required Acidic pH
as an internal stimulus is particular appealing because of the mildly acid pH encountered in tumor tissues and
the intracellular compartments such as endosomes and lysosomes Therefore the pH-responsive drug carriers
have been extensively developed for improving intracellular drug delivery To realize the pH-responsive drug
release we adopted a simple approach to design the lipidPEG-containing complex vesicles with pH-triggered
transmembrane channels as a chemotherapy drug doxorubicin (DOX) delivery carrier In this study the
complex vesicles were attained by spontaneous co-assembly of poly(acrylic acid)-g-poly(monomethoxy
ethylene glycol) (PAAc-g-mPEG) with a cationic lipid didodecyldimethylammonium bromide (DDAB) in
aqueous phase of pH 89 via electrostatic interactions Through the formation of unionized AAc-rich
transmembrance channels of complex vesicles in weak acidic environments the acid-triggered rapid drug
release can be achieved
On the other hand for simultaneously monitoring disease progression and biological response after
treatments we developed a novel tumor-targeting polymersome system capable of delivering magnetic
resonance imaging (MRI) and chemotherapy The DOX-loaded magnetic polymersomes were first attained by
the self-assembly of lipid-containing copolymer poly(AAc-co-distearin acrylate) in aqueous solution
containing citric acid-coated superparamagnetic iron oxide nanoparticles (SPIONs) and followed by DOX
loading via electrostatic attraction To further functionalize these vesicles with superior in vivo colloidal
stability pH-tunable drug release and active tumor-targeting chitosan and poly( -glutamic
acid-co- -glutamyl oxysuccinimide)-g-PEG-folate (FA) were deposited in sequence onto the assembly outer
surfaces The interfacial nanogel layers via electrostatic interactions and in-situ covalent cross-linking were
thus produced Triggerable release of the encapsulated DOX was governed by dual external stimuli pH and
temperature When these theranostic NCPs were effectively internalized by HeLa cells via FA
receptor-mediated endocytosis and then exposed to high frequency magnetic fields (HFMF) the combined
effects of both pH and magnetic hyperthermia-triggered drug release and thermo-therapy resulted in greater
cytotoxicity than the treatment by DOX alone By virtue of the SPION clustering effect in the assembly inner
aqueous compartments the SPIONDOX-loaded NCPs displayed an r2 relaxivity value higher than Resovist
a commercial SPION-based T2 contrast agent The high magnetic relaxivity of the tumor-targeting NCPs
coupled with their enhanced cellular uptake considerably promoted the MRI contrast of targeted cancer cells
These results demonstrate the great potential of the FA-decorated SPIONDOX-loaded NCPs as an advanced
cancer theranostic nanodevice
21
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-1 Prof Hao-Li Liu Professor and Director
Department of Electrical Engineering
Chang Gung University
Phone +886-3-2118800 ext 5677
Fax +886-3-2118026
E-mail haoliliumailcguedutw
Education 2003 PhD National Taiwan University Taipei TAIWAN 1998 M S National Taiwan University Taipei TAIWAN 1996 B S National Taipei University of Technology TAIWAN
Professional Experience 2012-present Director Dept of Electrical Engineering Chang Gung Univ Taiwan 2011-present Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2008 Associate Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2005 ndash2008 Assistant Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2004 ndash2005 Research Fellow Department of Radiology Brigham amp Womenrsquos Hospital Harvard Medical School MA USA
Honor and awards (2009~) 2013 Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) 2013 The 2013 Frederick Lizzi Award International Society of Therapeutic Ultrasound 2011 Distinguished Tech-Coop Award (長庚大學優良教師技合獎) Chang-Gung University 2011 Wu Ta-You Memorial Award (吳大猷先生紀念獎) National Science Council Taiwan 2011 2010 Distinguished Research Award (長庚大學優良教師研究獎) Chang-Gung University
Selected Publication (2010~) HW Yang MY Hua TL Hwang KJ Lin CY Huang RY Tsai CCM Ma PH Hsu SP Wey PW Hsu PY Chen YC Huang YJ Lu TC Yen LY Feng CW Lin HL Liu KC Wei Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide Advanced Materials Vol 25 No 26 pp3605-3611 2013 HL Liu CH Fan CY Ting and CK Yeh Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors Theranostics Vol 4 No 4 pp432-444 2014 KC Wei PC Chu HYJ Wang CY Huang PY Chen HC Tsai YJ Lu IC Tseng PY Lee TC Yen and HL Liu Focused Ultrasound-induced BloodndashBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment A Preclinical Study PLoS ONE Vol 8 No 3 pp e58995 2013 P-H Hsu K-C Wei C-Y Huang C-J Wen T-C Yen C-L Liu Y-T Lin J-C Chen C-R Shen and H-L Liu Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound PLoS ONE Vol 8 No 2 pp e57682 2013 H-L Liu M-Y Hua H-W Yang C-Y Huang P-C Chu J-S Wua I-C Tseng J-J Wang T-C Yen P-Y Chen and K-C Wei ldquoMagnetic resonance monitoring of focused ultrasoundmagnetic nanoparticle targeting delivery of therapeutic agents to the brainrdquo Proceedings of National Academy of Science USA Vol 107 No 34 pp15205-15210 2010 H-L Liu M-Y Hua P-Y Chen P-C Chu C-H Pan H-W Yang C-Y Huang J-J Wang T-C Yen and K-C Wei ldquoBloodndashBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatmentrdquo Radiology Vol 255 No 2 pp 415-425 2010 H-L Liu Y-Y Wai P-H Hsu L-A Lyu J-S Wu C-R Shen J-C Chen T-C Yen and J-J Wang ldquoIn Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Bloodndashbrain Barrier with Focused Ultrasound A Magnetic Resonance Imaging Studyrdquo Journal of Cerebral Blood Flow amp Metabolism Vol 30 pp 168-177 2010
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
13
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-2 Dr Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences
University of Tsukuba
Address Tennoudai 1-1-1 Tsukuba Ibaraki 305-8573 Japan
E-mailikedaimstsukubaacjp
Education March 1999 B S in Faculty of Engineering Kyoto University March 2001 MS in Graduate School of Engineering Department of Synthetic Chemistry and
Biological Chemistry Kyoto University March 2004 PhD in School of Engineering The University of Tokyo
Professional Experience 2004~2006 Advanced industrial science and technology (AIST) 2006~2008 Cytopathfinder Inc 2008~to date University of Tsukuba
Selected Publication (2010~) Y Ikeda J Katamachi H Kawasaki Y Nagasaki Novel protein PEGylation chemistry via glutalaldehydefunctionalized PEG Bioconjugate Chemistry 24 1824-1827 (2013) Y Ikeda D Kubota Y Nagasaki Design of sugar-oligonucleotide conjugates installed gold nanoparticle for effective delivery to hepatic parenchymal cells Colloid and Polymer Science 291 2959-2964 Y Ikeda H Kawasaki S Ichinohe Y Nagasaki Facile solid-phase synthesis of a highly stable poly(ethylene glycol)-oligonucleotide conjugate Journal of Materials Chemistry B 1 529-535(2013) Y Ikeda T Jomura U Horiuchi J Saeki K Yoshimoto T Ikeya Y Nagasaki Long-term survival and functional maintenance of hepatocytes by using a microfabricated cell array Colloid and Surface B Biointerface 97 97-100 2012 Y Ikeda Y Nagasaki PEGylation Technology in Nanomedicine Advances in Polymer Science 247 115-140 2012 Y Ikeda R Suzuki T Yoshitomi Y Nagasaki Novel oligonucleotide carrier possessing reactive oxygen species scavenging ability Macromolecular Bioscience 2011 11 344-351 Y Ikeda D Kubota Y Nagasaki Simple solid-phase synthesis and biological properties of carbohydrate-oligonucleotide conjugates modified at the 3rsquo terminus Bioconjugate Chem 2010 21 1685-1690
14
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-2 Sep 13 2014 (Sat) 0945-1015 at NTHU BMES R120
Chemical Modifications for the Developments of Next Generation Drugs
Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences University of
Tsukuba
Controlling of biodistribution and PKPD is a key issue for the development of drugsVariety of
technologies have been reported to improve those properties Those technologies include
nanoparticle formulation and PEGylation technology In my presentation I will show recent
chemical modification technologies which we developed to improve PKPD and distribution of
drugs
A novel chemistry for the PEGylated protein with a high activity
Several PEGylated proteins have been approved as therapeutic drugs In many cases PEGylated
protein has been synthesized by the conjugation reaction between PEG possessing activated ester and
amine(s) in the protein This reaction however often causes inactivation of PEGylated proteins In
this report we present a novel chemistry which enables the PEGylation of proteins under the mild
reaction condition PEGylated lysozyme prepared by the method developed increased the biological
activity of the PEGylated lysozyme more than 20 times compared with the PEGylated lysozyme
prepared by the conventional method
Design and development of novel hypoxically activated prodrugs
Tumor hypoxia is well known to promote mutagenesis invasiveness and to be associated with a
worse prognosis Although the treatment of the tumor hypoxia has been highly demanded resistance
to radiotherapy and anticancer chemotherapy have been serious problems The object of this study
was the development of hypoxically activated prodrugs which accumulate and act on cells at hypoxic
region of tumor Several conventional anti-cancer drugs including doxorubicin gemcitabine and 5FU
have been modified with 2-nitro imidazole derivative This modification enabled inactivation of drug
to reduce adverse effects under the normoxia condition and selective activation of prodrug under the
hypoxic condition
15
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-3 Prof Tzu-Wei Wang
Associate Professor
Department of Materials Science and Engineering and Institute of Biomedical
Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013
Office Delta Teaching Building R434
TEL +886-3-5715131 ext 33856
Email twwangmxnthuedutw Education 2006 PhD Institute of Biomedical Engineering National Taiwan University Taiwan
Professional Experience 2013 ndashpresent Associate Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2009 -2013 Assistant Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2007-2009 Postdoctoral Research Fellow Tissue Engineering Laboratories of Brigham and Womenrsquos
Hospital Harvard Medical School USA
Honor and awards (2009~) Young Plenary Award 2013 TERMIS-AP Symposium Shanghai China (2013) The 9th National Innovation Award Academic Research Category by Institute for Biotechnology and Medicine Industry Taiwan (2012) Young Investigator Award International Symposium of Materials on Regenerative Medicine Taiwan (2012 ISOMRM) Young Investigator Award 5th World Congress on Bioengineering the World Association for Chinese Biomedical Engineers Taiwan (WACBE 2011)
Selected Publication (2012~) Yang CS Wu HC Sun JS Hsiao HM Wang TW Thermo-induced shape memory PEG-PCL copolymer as dual drug-eluting biodegradable stent ACS Appl Mater Interfaces 2013 5 (21) 10985ndash10994 Yeh PH Sun JS Wu HC Hwang LH Wang TW Stimuli-responsive HA-PEI nanoparticles encapsulating endostatin plasmid for stem cell gene therapy RSC Advances 2013 3 (31) 12922 - 12932 Chen YY Wu HC Sun JS Dong GC Wang TW Injectable and thermoresponsive self-assembled nanocomposite hydrogel for long-term anticancer drug delivery Langmuir 201329(11)3721-3729 Cheng TY Wu HC Chang WH Huang MY Lee CH Wang TW Self-assembling functionalized nanopeptides for immediate hemostasis and accelerative liver tissue regeneration Nanoscale 2013 5 (7) 2734 - 2744 Chang YJ Tsai CJ Tseng FG Chen TJ Wang TW Micropatterned Stretching System for the Investigation of Mechanical Tension on Neural Stem Cells Behavior Nanomedicine Nanotechnology Biology and Medicine 20139345-355 Cheng TY Chen MH Chang WH Huang MY Wang TW Neural stem cells encapsulated in a functionalized self-assembling peptide hydrogel for brain tissue engineering Biomaterials 2013 34(8)2005-2016 Goh JH Wu HC Chen MH Chen MY Chang SC Wang TW Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages Acta Biomaterialia 20139(2)5170-5180 Huang YJ Wu HC Tai NH Wang TW Carbon Nanotube Rope with Electrical Stimulation Promotes the Differentiation and Maturity of Neural Stem Cells Small 20128(18) 2869ndash2877
16
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-3 Sep 13 2014 (Sat) 1015-1045 at NTHU BMES R120
Electrospun Composite Nanofibers with Staged Release of Multiple Angiogenic Growth Factors for Chronic Wound Healing
Tzu-Wei Wang
Department of Materials Science and Engineering and Institute of Biomedical Engineering National
Tsing Hua University
The objective of this research study is to develop collagen (Col) and hyaluronic acid (HA)
inter-stacking nanofibrous skin equivalent substitute with programmable release of multiple
angiogenic growth factors (VEGF PDGF bFGF and EGF) either directly embedded in the
nanofibers or encapsulated in the gelatin nanoparticles (GN) by electrospinning technology The
delivery of EGF and bFGF in early stage is expected to accelerate epithelialization and vasculature
sprouting while release of PDGF and VEGF in late stage is aimed for the induction of blood vessels
maturation The physiochemical characterizations report that the Col-HA-GN nanofibrous membrane
possesses mechanical property similar to human native skin The design of particle-in-fiber structure
allows growth factors for slow controlled release up to one month Cultured on biodegradable
Col-HA membrane with four kinds of growth factors (Col-HA w4GF) endothelial cells not only
increase in growth rate but also form better network of thread-like tubular structure Therapeutic
effect of Col-HA w4GF membrane on STZ-induced diabetic rats reveal accelerated wound closure
rate elevated collagen deposition and enhanced mature vessels by Massonrsquos trichrome stain and
immunohistochemical analysis respectively From the above the electrospun Col-HA-GN composite
nanofibrous skin substitute with stage-wise release pattern of multiple angiogenic factors could be a
promising bioengineered construct for the chronic wound healing in skin tissue regeneration
17
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-4 Assistant Prof Ryo Ishihara
Assistant Professor
Department of Materials Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
Tokyo University of Science Research Building 9th floor
TEL +81-3-5876-1415
FAX +81-3-5876-1415
Education 2012 PhD Department of Applied Chemistry and Biotechnology Chiba University Japan 2008 MS Department of Materials Technology Chiba University Japan 2006 BS Department of Materials Technology Chiba University Japan
Professional Experience 2014 ndashpresent Assistant Professor Department of Materials Science and Technology Tokyo
University of Science 2012 ndash2014 Postdoctral Researcher Bioengineering Laboratory RIKEN
Honor and awards Department chairmanlsquos award from Chiba University (2012)
Selected Publication (2010~) Simple Method for High-Density Impregnation of Aliquat 336 onto Porous Sheet and Binding Performance of Resulting Sheet for Palladium Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota Sep Sci Technol 49154-159 (2014) Effect of Dose on Mole Percentage of Polymer Brush and Root Grafted onto Porous Polyethylene Sheet by Radiation-Induced Graft Polymerization R Ishihara S Uchiyama H Ikezawa S Yamada H Hirota D Umeno K Saito Ind Eng Chem Res 5212582-12586 (2013) Determination of Mole Percentages of Brush and Root of Polymer Chain Grafted onto Porous Sheet S Uchiyama R Ishihara D Umeno K Saito S Yamada H Hirota S Asai J Chem Eng Japan 46414-419 (2013) Crosslinked-chelating Porous Sheet with High Dynamic Binding Capacity of Metal Ions G Wada R Ishihara K Miyoshi D Umeno K Saito S Yamada H Hirota Solv Extr Ion Exch 31210-220 (2013) Dependence of Lanthanide-Ion Binding Performance on HDEHP Concentration in HDEHP Impregnation to Porous Sheet R Ishihara S Asai S Otosaka S Yamada H Hirota K Miyoshi D Umeno K Saito Solv Extr Ion Exch 30171-180 (2012) Impregnation of TOPO onto Hydrophobic-Ligand-Containing Porous Sheet and Its Adsorptionelution Performance of Bismuth Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota React Funct Polym 70986-990 (2010)
18
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-4 Sep 13 2014 (Sat) 1110-1140 at NTHU BMES R120
Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip toward Point-of-Care Diagnosis
Ryo Ishihara Kazuo Hosokawa Mizuo Maeda
Bioengineering Laboratory RIKEN
MicroRNAs (miRNAs) are short and non-protein-coding single-stranded RNAs and have shown great promise for
cancer diagnosis Some miRNAs circulate in human body fluid with extremely low concentrations and its expression
profiling can detect and classify cancers in the human body [1] Point-of-care (POC) diagnosis requires short detection
time small required sample volume and portability of the device In various miRNA detection methods microfluidic
chip meets the requirements except the portability Hence we used our power-free pump-free microfluidic chip driven
by energy that is stored in degased PDMS to overcome those drawbacks which eliminates the need for external power
sources for fluid pumping [2] The pump-free pumping method is essential for microfluidic chip-based POC diagnosis In
our laboratory rapid and sensitive singleplex miRNA detection with laminar flow-assisted dendritic amplification (LFDA)
[3] on the pump-free microfluidic chip has been developed [4] In this study rapid and sensitive multiplex miRNA
detection on the pump-free microfluidic chip was demonstrated
Pump-free microchip for multiplex miRNA detection was prepared as follows First the PDMS part with a pair of
Y-shaped microchannels with 100 μm in width and 25 μm in height was fabricated Second three parallel-line-shaped
probe DNAs were patterned onto a glass surface Third the PDMS channels were attached onto the glass plate Finally
the chip was degassed in a vacuum chamber After the chip preparation target miRNAs were detected following three
steps (1) blocking (2) sandwich hybridization of the target miRNAs and biotinylated probe DNAs and (3) signal
amplification by LFDA MiR-16 miR-21-5p and miR-500a-3p were used as target miRNAs since they are known as
cancer biomarkers [5-7] Fluorescence signals were captured by CCD camera and analyzed by the software (ImageJ)
Bright lines appeared at the expected positions they appeared only on the areas with the respective probe DNA in which
the target miRNAs had been supplied These data prove that the LFDA successfully took place in a target
sequence-dependent manner Calibration curves were plotted from the fluorescence signals The data points of the
calibration curve were fitted with the four-parameter logistic function and limit-of-detections (LODs) were evaluated by
the 3σ criterion LODs of the miR-16 miR-21-5p and miR-500a-3p were 68 fM 15 pM and 150 fM respectively The
LODs are on the same order of magnitude as concentrations of miRNA in blood Multiplex detection was verified from
correspondence between the calibration curves of single and multiplex The required sample volume was 05 microL and
assay time was 20 min Because most of the existing methods take more than a few hours the rapidness small required
sample volume and portability of the device are ideal advantages for POC diagnosis
References
[1] PS Mitchell et al PNAS 105 (2008) 10513 [2] K Hosokawa et al Lab Chip 4 (2004) 181 [3] K Hosokawa et al Anal
Chem 79 (2007) 6000 [4] H Arata et al PLoS ONE 7 (2012) e48329 [5] MJ Lodes et al PLoS ONE 4 (2009) e6229
[6] Y Toiyama et al J Natl Cancer Inst 105 (2013) 849 [7] Y Yamamoto et al Biomarkers 14 (2009) 529
19
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-5 Dr Wen-Hsuan Chiang
Assistant Researcher
Department of Biomedical Engineering and Environmental Sciences
National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
TEL (886) 3-571-5131 ext 35576
Education 2009 PhD Department of Chemical Engineering National Chung Hsing University Taiwan Thesis Supervisor Professor Hsin-Cheng Chiu 2002 BS Department of Chemical Engineering Tatung University Taiwan Professional Experience 2013 ndashpresent Assistant Researcher Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University 2010 ndash2012 Postdoctoral Fellow Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
Areas of Research Expertise Biomaterials Smart Amphiphilic Copolymers Multifunctional Nanocarriers for Cancer Therapy and Imaging Nano Science and Interfacial Engineering
Selected Publication (2010~) Wen-Hsuan Chiang Wen-Chia Huang Ming-Yin Shen Che-Hsu Wang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Dual-Layered Nanogel-Coated Hollow LipidPolypeptide Conjugate Assemblies for Potential pH-Triggered Intracellular Drug Release PLOS ONE 2014 9 1-11 Wen-Hsuan Chiang Wen-Chia Huang Chien-Wen Chang Ming-Yin Shen Zong-Fu Shih Yi-Fong Huang Sung-Chyr Lin Hsin-Cheng Chiu Functionalized Polymersomes with Outlayered Polyelectrolyte Gels for Potential Tumor-Targeted Delivery of Multimodal Therapies and MR Imaging Journal of Controlled Release 2013 168 280-288 Wen-Hsuan Chiang Viet Thang Ho Hsin-Hung Chen Wen-Chia Huang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Superparamagnetic Hollow Hybrid Nanogels as a Potential Guidable Vehicle System of Stimuli-Mediated MR Imaging and Multiple Cancer Therapeutics Langmuir 2013 29 6434-6443 Wen-Hsuan Chiang Viet Thang Ho Wen-Chia Huang Yi-Fong Huang Chorng-Shyan Chern Hsin-Cheng Chiu Dual Stimuli-Responsive Polymeric Hollow Nanogels Designed as Carriers for Intracellular Triggered Drug Release Langmuir 2012 28 15056-15064 Yi-Fong HuangDagger Wen-Hsuan ChiangDagger Pei-Ling Tsai Chorng-Shyan Chern Hsin-Cheng Chiu Novel Hybrid Vesicles Co-Assembled from Cationic Lipid and PAAc-g-mPEG with pH-Triggered Transmembrane Channels for Controlled Drug Release Chemical Communications 2011 47 10978-10980
20
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-5 Sep 13 2014 (Sat) 1140-1210 at NTHU BMES R120 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and Imaging
Applications
Wen-Hsuan Chiang
Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
In order to promote therapeutic efficacy and minimize side effect equipping these nanocarriers with the
capability of controlling drug release in response to an appropriate stimulus is essentially required Acidic pH
as an internal stimulus is particular appealing because of the mildly acid pH encountered in tumor tissues and
the intracellular compartments such as endosomes and lysosomes Therefore the pH-responsive drug carriers
have been extensively developed for improving intracellular drug delivery To realize the pH-responsive drug
release we adopted a simple approach to design the lipidPEG-containing complex vesicles with pH-triggered
transmembrane channels as a chemotherapy drug doxorubicin (DOX) delivery carrier In this study the
complex vesicles were attained by spontaneous co-assembly of poly(acrylic acid)-g-poly(monomethoxy
ethylene glycol) (PAAc-g-mPEG) with a cationic lipid didodecyldimethylammonium bromide (DDAB) in
aqueous phase of pH 89 via electrostatic interactions Through the formation of unionized AAc-rich
transmembrance channels of complex vesicles in weak acidic environments the acid-triggered rapid drug
release can be achieved
On the other hand for simultaneously monitoring disease progression and biological response after
treatments we developed a novel tumor-targeting polymersome system capable of delivering magnetic
resonance imaging (MRI) and chemotherapy The DOX-loaded magnetic polymersomes were first attained by
the self-assembly of lipid-containing copolymer poly(AAc-co-distearin acrylate) in aqueous solution
containing citric acid-coated superparamagnetic iron oxide nanoparticles (SPIONs) and followed by DOX
loading via electrostatic attraction To further functionalize these vesicles with superior in vivo colloidal
stability pH-tunable drug release and active tumor-targeting chitosan and poly( -glutamic
acid-co- -glutamyl oxysuccinimide)-g-PEG-folate (FA) were deposited in sequence onto the assembly outer
surfaces The interfacial nanogel layers via electrostatic interactions and in-situ covalent cross-linking were
thus produced Triggerable release of the encapsulated DOX was governed by dual external stimuli pH and
temperature When these theranostic NCPs were effectively internalized by HeLa cells via FA
receptor-mediated endocytosis and then exposed to high frequency magnetic fields (HFMF) the combined
effects of both pH and magnetic hyperthermia-triggered drug release and thermo-therapy resulted in greater
cytotoxicity than the treatment by DOX alone By virtue of the SPION clustering effect in the assembly inner
aqueous compartments the SPIONDOX-loaded NCPs displayed an r2 relaxivity value higher than Resovist
a commercial SPION-based T2 contrast agent The high magnetic relaxivity of the tumor-targeting NCPs
coupled with their enhanced cellular uptake considerably promoted the MRI contrast of targeted cancer cells
These results demonstrate the great potential of the FA-decorated SPIONDOX-loaded NCPs as an advanced
cancer theranostic nanodevice
21
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-1 Prof Hao-Li Liu Professor and Director
Department of Electrical Engineering
Chang Gung University
Phone +886-3-2118800 ext 5677
Fax +886-3-2118026
E-mail haoliliumailcguedutw
Education 2003 PhD National Taiwan University Taipei TAIWAN 1998 M S National Taiwan University Taipei TAIWAN 1996 B S National Taipei University of Technology TAIWAN
Professional Experience 2012-present Director Dept of Electrical Engineering Chang Gung Univ Taiwan 2011-present Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2008 Associate Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2005 ndash2008 Assistant Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2004 ndash2005 Research Fellow Department of Radiology Brigham amp Womenrsquos Hospital Harvard Medical School MA USA
Honor and awards (2009~) 2013 Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) 2013 The 2013 Frederick Lizzi Award International Society of Therapeutic Ultrasound 2011 Distinguished Tech-Coop Award (長庚大學優良教師技合獎) Chang-Gung University 2011 Wu Ta-You Memorial Award (吳大猷先生紀念獎) National Science Council Taiwan 2011 2010 Distinguished Research Award (長庚大學優良教師研究獎) Chang-Gung University
Selected Publication (2010~) HW Yang MY Hua TL Hwang KJ Lin CY Huang RY Tsai CCM Ma PH Hsu SP Wey PW Hsu PY Chen YC Huang YJ Lu TC Yen LY Feng CW Lin HL Liu KC Wei Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide Advanced Materials Vol 25 No 26 pp3605-3611 2013 HL Liu CH Fan CY Ting and CK Yeh Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors Theranostics Vol 4 No 4 pp432-444 2014 KC Wei PC Chu HYJ Wang CY Huang PY Chen HC Tsai YJ Lu IC Tseng PY Lee TC Yen and HL Liu Focused Ultrasound-induced BloodndashBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment A Preclinical Study PLoS ONE Vol 8 No 3 pp e58995 2013 P-H Hsu K-C Wei C-Y Huang C-J Wen T-C Yen C-L Liu Y-T Lin J-C Chen C-R Shen and H-L Liu Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound PLoS ONE Vol 8 No 2 pp e57682 2013 H-L Liu M-Y Hua H-W Yang C-Y Huang P-C Chu J-S Wua I-C Tseng J-J Wang T-C Yen P-Y Chen and K-C Wei ldquoMagnetic resonance monitoring of focused ultrasoundmagnetic nanoparticle targeting delivery of therapeutic agents to the brainrdquo Proceedings of National Academy of Science USA Vol 107 No 34 pp15205-15210 2010 H-L Liu M-Y Hua P-Y Chen P-C Chu C-H Pan H-W Yang C-Y Huang J-J Wang T-C Yen and K-C Wei ldquoBloodndashBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatmentrdquo Radiology Vol 255 No 2 pp 415-425 2010 H-L Liu Y-Y Wai P-H Hsu L-A Lyu J-S Wu C-R Shen J-C Chen T-C Yen and J-J Wang ldquoIn Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Bloodndashbrain Barrier with Focused Ultrasound A Magnetic Resonance Imaging Studyrdquo Journal of Cerebral Blood Flow amp Metabolism Vol 30 pp 168-177 2010
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
14
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-2 Sep 13 2014 (Sat) 0945-1015 at NTHU BMES R120
Chemical Modifications for the Developments of Next Generation Drugs
Yutaka Ikeda
Department of Materials Science Graduate School of Pure and Applied Sciences University of
Tsukuba
Controlling of biodistribution and PKPD is a key issue for the development of drugsVariety of
technologies have been reported to improve those properties Those technologies include
nanoparticle formulation and PEGylation technology In my presentation I will show recent
chemical modification technologies which we developed to improve PKPD and distribution of
drugs
A novel chemistry for the PEGylated protein with a high activity
Several PEGylated proteins have been approved as therapeutic drugs In many cases PEGylated
protein has been synthesized by the conjugation reaction between PEG possessing activated ester and
amine(s) in the protein This reaction however often causes inactivation of PEGylated proteins In
this report we present a novel chemistry which enables the PEGylation of proteins under the mild
reaction condition PEGylated lysozyme prepared by the method developed increased the biological
activity of the PEGylated lysozyme more than 20 times compared with the PEGylated lysozyme
prepared by the conventional method
Design and development of novel hypoxically activated prodrugs
Tumor hypoxia is well known to promote mutagenesis invasiveness and to be associated with a
worse prognosis Although the treatment of the tumor hypoxia has been highly demanded resistance
to radiotherapy and anticancer chemotherapy have been serious problems The object of this study
was the development of hypoxically activated prodrugs which accumulate and act on cells at hypoxic
region of tumor Several conventional anti-cancer drugs including doxorubicin gemcitabine and 5FU
have been modified with 2-nitro imidazole derivative This modification enabled inactivation of drug
to reduce adverse effects under the normoxia condition and selective activation of prodrug under the
hypoxic condition
15
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-3 Prof Tzu-Wei Wang
Associate Professor
Department of Materials Science and Engineering and Institute of Biomedical
Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013
Office Delta Teaching Building R434
TEL +886-3-5715131 ext 33856
Email twwangmxnthuedutw Education 2006 PhD Institute of Biomedical Engineering National Taiwan University Taiwan
Professional Experience 2013 ndashpresent Associate Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2009 -2013 Assistant Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2007-2009 Postdoctoral Research Fellow Tissue Engineering Laboratories of Brigham and Womenrsquos
Hospital Harvard Medical School USA
Honor and awards (2009~) Young Plenary Award 2013 TERMIS-AP Symposium Shanghai China (2013) The 9th National Innovation Award Academic Research Category by Institute for Biotechnology and Medicine Industry Taiwan (2012) Young Investigator Award International Symposium of Materials on Regenerative Medicine Taiwan (2012 ISOMRM) Young Investigator Award 5th World Congress on Bioengineering the World Association for Chinese Biomedical Engineers Taiwan (WACBE 2011)
Selected Publication (2012~) Yang CS Wu HC Sun JS Hsiao HM Wang TW Thermo-induced shape memory PEG-PCL copolymer as dual drug-eluting biodegradable stent ACS Appl Mater Interfaces 2013 5 (21) 10985ndash10994 Yeh PH Sun JS Wu HC Hwang LH Wang TW Stimuli-responsive HA-PEI nanoparticles encapsulating endostatin plasmid for stem cell gene therapy RSC Advances 2013 3 (31) 12922 - 12932 Chen YY Wu HC Sun JS Dong GC Wang TW Injectable and thermoresponsive self-assembled nanocomposite hydrogel for long-term anticancer drug delivery Langmuir 201329(11)3721-3729 Cheng TY Wu HC Chang WH Huang MY Lee CH Wang TW Self-assembling functionalized nanopeptides for immediate hemostasis and accelerative liver tissue regeneration Nanoscale 2013 5 (7) 2734 - 2744 Chang YJ Tsai CJ Tseng FG Chen TJ Wang TW Micropatterned Stretching System for the Investigation of Mechanical Tension on Neural Stem Cells Behavior Nanomedicine Nanotechnology Biology and Medicine 20139345-355 Cheng TY Chen MH Chang WH Huang MY Wang TW Neural stem cells encapsulated in a functionalized self-assembling peptide hydrogel for brain tissue engineering Biomaterials 2013 34(8)2005-2016 Goh JH Wu HC Chen MH Chen MY Chang SC Wang TW Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages Acta Biomaterialia 20139(2)5170-5180 Huang YJ Wu HC Tai NH Wang TW Carbon Nanotube Rope with Electrical Stimulation Promotes the Differentiation and Maturity of Neural Stem Cells Small 20128(18) 2869ndash2877
16
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-3 Sep 13 2014 (Sat) 1015-1045 at NTHU BMES R120
Electrospun Composite Nanofibers with Staged Release of Multiple Angiogenic Growth Factors for Chronic Wound Healing
Tzu-Wei Wang
Department of Materials Science and Engineering and Institute of Biomedical Engineering National
Tsing Hua University
The objective of this research study is to develop collagen (Col) and hyaluronic acid (HA)
inter-stacking nanofibrous skin equivalent substitute with programmable release of multiple
angiogenic growth factors (VEGF PDGF bFGF and EGF) either directly embedded in the
nanofibers or encapsulated in the gelatin nanoparticles (GN) by electrospinning technology The
delivery of EGF and bFGF in early stage is expected to accelerate epithelialization and vasculature
sprouting while release of PDGF and VEGF in late stage is aimed for the induction of blood vessels
maturation The physiochemical characterizations report that the Col-HA-GN nanofibrous membrane
possesses mechanical property similar to human native skin The design of particle-in-fiber structure
allows growth factors for slow controlled release up to one month Cultured on biodegradable
Col-HA membrane with four kinds of growth factors (Col-HA w4GF) endothelial cells not only
increase in growth rate but also form better network of thread-like tubular structure Therapeutic
effect of Col-HA w4GF membrane on STZ-induced diabetic rats reveal accelerated wound closure
rate elevated collagen deposition and enhanced mature vessels by Massonrsquos trichrome stain and
immunohistochemical analysis respectively From the above the electrospun Col-HA-GN composite
nanofibrous skin substitute with stage-wise release pattern of multiple angiogenic factors could be a
promising bioengineered construct for the chronic wound healing in skin tissue regeneration
17
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-4 Assistant Prof Ryo Ishihara
Assistant Professor
Department of Materials Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
Tokyo University of Science Research Building 9th floor
TEL +81-3-5876-1415
FAX +81-3-5876-1415
Education 2012 PhD Department of Applied Chemistry and Biotechnology Chiba University Japan 2008 MS Department of Materials Technology Chiba University Japan 2006 BS Department of Materials Technology Chiba University Japan
Professional Experience 2014 ndashpresent Assistant Professor Department of Materials Science and Technology Tokyo
University of Science 2012 ndash2014 Postdoctral Researcher Bioengineering Laboratory RIKEN
Honor and awards Department chairmanlsquos award from Chiba University (2012)
Selected Publication (2010~) Simple Method for High-Density Impregnation of Aliquat 336 onto Porous Sheet and Binding Performance of Resulting Sheet for Palladium Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota Sep Sci Technol 49154-159 (2014) Effect of Dose on Mole Percentage of Polymer Brush and Root Grafted onto Porous Polyethylene Sheet by Radiation-Induced Graft Polymerization R Ishihara S Uchiyama H Ikezawa S Yamada H Hirota D Umeno K Saito Ind Eng Chem Res 5212582-12586 (2013) Determination of Mole Percentages of Brush and Root of Polymer Chain Grafted onto Porous Sheet S Uchiyama R Ishihara D Umeno K Saito S Yamada H Hirota S Asai J Chem Eng Japan 46414-419 (2013) Crosslinked-chelating Porous Sheet with High Dynamic Binding Capacity of Metal Ions G Wada R Ishihara K Miyoshi D Umeno K Saito S Yamada H Hirota Solv Extr Ion Exch 31210-220 (2013) Dependence of Lanthanide-Ion Binding Performance on HDEHP Concentration in HDEHP Impregnation to Porous Sheet R Ishihara S Asai S Otosaka S Yamada H Hirota K Miyoshi D Umeno K Saito Solv Extr Ion Exch 30171-180 (2012) Impregnation of TOPO onto Hydrophobic-Ligand-Containing Porous Sheet and Its Adsorptionelution Performance of Bismuth Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota React Funct Polym 70986-990 (2010)
18
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-4 Sep 13 2014 (Sat) 1110-1140 at NTHU BMES R120
Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip toward Point-of-Care Diagnosis
Ryo Ishihara Kazuo Hosokawa Mizuo Maeda
Bioengineering Laboratory RIKEN
MicroRNAs (miRNAs) are short and non-protein-coding single-stranded RNAs and have shown great promise for
cancer diagnosis Some miRNAs circulate in human body fluid with extremely low concentrations and its expression
profiling can detect and classify cancers in the human body [1] Point-of-care (POC) diagnosis requires short detection
time small required sample volume and portability of the device In various miRNA detection methods microfluidic
chip meets the requirements except the portability Hence we used our power-free pump-free microfluidic chip driven
by energy that is stored in degased PDMS to overcome those drawbacks which eliminates the need for external power
sources for fluid pumping [2] The pump-free pumping method is essential for microfluidic chip-based POC diagnosis In
our laboratory rapid and sensitive singleplex miRNA detection with laminar flow-assisted dendritic amplification (LFDA)
[3] on the pump-free microfluidic chip has been developed [4] In this study rapid and sensitive multiplex miRNA
detection on the pump-free microfluidic chip was demonstrated
Pump-free microchip for multiplex miRNA detection was prepared as follows First the PDMS part with a pair of
Y-shaped microchannels with 100 μm in width and 25 μm in height was fabricated Second three parallel-line-shaped
probe DNAs were patterned onto a glass surface Third the PDMS channels were attached onto the glass plate Finally
the chip was degassed in a vacuum chamber After the chip preparation target miRNAs were detected following three
steps (1) blocking (2) sandwich hybridization of the target miRNAs and biotinylated probe DNAs and (3) signal
amplification by LFDA MiR-16 miR-21-5p and miR-500a-3p were used as target miRNAs since they are known as
cancer biomarkers [5-7] Fluorescence signals were captured by CCD camera and analyzed by the software (ImageJ)
Bright lines appeared at the expected positions they appeared only on the areas with the respective probe DNA in which
the target miRNAs had been supplied These data prove that the LFDA successfully took place in a target
sequence-dependent manner Calibration curves were plotted from the fluorescence signals The data points of the
calibration curve were fitted with the four-parameter logistic function and limit-of-detections (LODs) were evaluated by
the 3σ criterion LODs of the miR-16 miR-21-5p and miR-500a-3p were 68 fM 15 pM and 150 fM respectively The
LODs are on the same order of magnitude as concentrations of miRNA in blood Multiplex detection was verified from
correspondence between the calibration curves of single and multiplex The required sample volume was 05 microL and
assay time was 20 min Because most of the existing methods take more than a few hours the rapidness small required
sample volume and portability of the device are ideal advantages for POC diagnosis
References
[1] PS Mitchell et al PNAS 105 (2008) 10513 [2] K Hosokawa et al Lab Chip 4 (2004) 181 [3] K Hosokawa et al Anal
Chem 79 (2007) 6000 [4] H Arata et al PLoS ONE 7 (2012) e48329 [5] MJ Lodes et al PLoS ONE 4 (2009) e6229
[6] Y Toiyama et al J Natl Cancer Inst 105 (2013) 849 [7] Y Yamamoto et al Biomarkers 14 (2009) 529
19
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-5 Dr Wen-Hsuan Chiang
Assistant Researcher
Department of Biomedical Engineering and Environmental Sciences
National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
TEL (886) 3-571-5131 ext 35576
Education 2009 PhD Department of Chemical Engineering National Chung Hsing University Taiwan Thesis Supervisor Professor Hsin-Cheng Chiu 2002 BS Department of Chemical Engineering Tatung University Taiwan Professional Experience 2013 ndashpresent Assistant Researcher Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University 2010 ndash2012 Postdoctoral Fellow Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
Areas of Research Expertise Biomaterials Smart Amphiphilic Copolymers Multifunctional Nanocarriers for Cancer Therapy and Imaging Nano Science and Interfacial Engineering
Selected Publication (2010~) Wen-Hsuan Chiang Wen-Chia Huang Ming-Yin Shen Che-Hsu Wang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Dual-Layered Nanogel-Coated Hollow LipidPolypeptide Conjugate Assemblies for Potential pH-Triggered Intracellular Drug Release PLOS ONE 2014 9 1-11 Wen-Hsuan Chiang Wen-Chia Huang Chien-Wen Chang Ming-Yin Shen Zong-Fu Shih Yi-Fong Huang Sung-Chyr Lin Hsin-Cheng Chiu Functionalized Polymersomes with Outlayered Polyelectrolyte Gels for Potential Tumor-Targeted Delivery of Multimodal Therapies and MR Imaging Journal of Controlled Release 2013 168 280-288 Wen-Hsuan Chiang Viet Thang Ho Hsin-Hung Chen Wen-Chia Huang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Superparamagnetic Hollow Hybrid Nanogels as a Potential Guidable Vehicle System of Stimuli-Mediated MR Imaging and Multiple Cancer Therapeutics Langmuir 2013 29 6434-6443 Wen-Hsuan Chiang Viet Thang Ho Wen-Chia Huang Yi-Fong Huang Chorng-Shyan Chern Hsin-Cheng Chiu Dual Stimuli-Responsive Polymeric Hollow Nanogels Designed as Carriers for Intracellular Triggered Drug Release Langmuir 2012 28 15056-15064 Yi-Fong HuangDagger Wen-Hsuan ChiangDagger Pei-Ling Tsai Chorng-Shyan Chern Hsin-Cheng Chiu Novel Hybrid Vesicles Co-Assembled from Cationic Lipid and PAAc-g-mPEG with pH-Triggered Transmembrane Channels for Controlled Drug Release Chemical Communications 2011 47 10978-10980
20
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-5 Sep 13 2014 (Sat) 1140-1210 at NTHU BMES R120 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and Imaging
Applications
Wen-Hsuan Chiang
Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
In order to promote therapeutic efficacy and minimize side effect equipping these nanocarriers with the
capability of controlling drug release in response to an appropriate stimulus is essentially required Acidic pH
as an internal stimulus is particular appealing because of the mildly acid pH encountered in tumor tissues and
the intracellular compartments such as endosomes and lysosomes Therefore the pH-responsive drug carriers
have been extensively developed for improving intracellular drug delivery To realize the pH-responsive drug
release we adopted a simple approach to design the lipidPEG-containing complex vesicles with pH-triggered
transmembrane channels as a chemotherapy drug doxorubicin (DOX) delivery carrier In this study the
complex vesicles were attained by spontaneous co-assembly of poly(acrylic acid)-g-poly(monomethoxy
ethylene glycol) (PAAc-g-mPEG) with a cationic lipid didodecyldimethylammonium bromide (DDAB) in
aqueous phase of pH 89 via electrostatic interactions Through the formation of unionized AAc-rich
transmembrance channels of complex vesicles in weak acidic environments the acid-triggered rapid drug
release can be achieved
On the other hand for simultaneously monitoring disease progression and biological response after
treatments we developed a novel tumor-targeting polymersome system capable of delivering magnetic
resonance imaging (MRI) and chemotherapy The DOX-loaded magnetic polymersomes were first attained by
the self-assembly of lipid-containing copolymer poly(AAc-co-distearin acrylate) in aqueous solution
containing citric acid-coated superparamagnetic iron oxide nanoparticles (SPIONs) and followed by DOX
loading via electrostatic attraction To further functionalize these vesicles with superior in vivo colloidal
stability pH-tunable drug release and active tumor-targeting chitosan and poly( -glutamic
acid-co- -glutamyl oxysuccinimide)-g-PEG-folate (FA) were deposited in sequence onto the assembly outer
surfaces The interfacial nanogel layers via electrostatic interactions and in-situ covalent cross-linking were
thus produced Triggerable release of the encapsulated DOX was governed by dual external stimuli pH and
temperature When these theranostic NCPs were effectively internalized by HeLa cells via FA
receptor-mediated endocytosis and then exposed to high frequency magnetic fields (HFMF) the combined
effects of both pH and magnetic hyperthermia-triggered drug release and thermo-therapy resulted in greater
cytotoxicity than the treatment by DOX alone By virtue of the SPION clustering effect in the assembly inner
aqueous compartments the SPIONDOX-loaded NCPs displayed an r2 relaxivity value higher than Resovist
a commercial SPION-based T2 contrast agent The high magnetic relaxivity of the tumor-targeting NCPs
coupled with their enhanced cellular uptake considerably promoted the MRI contrast of targeted cancer cells
These results demonstrate the great potential of the FA-decorated SPIONDOX-loaded NCPs as an advanced
cancer theranostic nanodevice
21
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-1 Prof Hao-Li Liu Professor and Director
Department of Electrical Engineering
Chang Gung University
Phone +886-3-2118800 ext 5677
Fax +886-3-2118026
E-mail haoliliumailcguedutw
Education 2003 PhD National Taiwan University Taipei TAIWAN 1998 M S National Taiwan University Taipei TAIWAN 1996 B S National Taipei University of Technology TAIWAN
Professional Experience 2012-present Director Dept of Electrical Engineering Chang Gung Univ Taiwan 2011-present Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2008 Associate Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2005 ndash2008 Assistant Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2004 ndash2005 Research Fellow Department of Radiology Brigham amp Womenrsquos Hospital Harvard Medical School MA USA
Honor and awards (2009~) 2013 Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) 2013 The 2013 Frederick Lizzi Award International Society of Therapeutic Ultrasound 2011 Distinguished Tech-Coop Award (長庚大學優良教師技合獎) Chang-Gung University 2011 Wu Ta-You Memorial Award (吳大猷先生紀念獎) National Science Council Taiwan 2011 2010 Distinguished Research Award (長庚大學優良教師研究獎) Chang-Gung University
Selected Publication (2010~) HW Yang MY Hua TL Hwang KJ Lin CY Huang RY Tsai CCM Ma PH Hsu SP Wey PW Hsu PY Chen YC Huang YJ Lu TC Yen LY Feng CW Lin HL Liu KC Wei Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide Advanced Materials Vol 25 No 26 pp3605-3611 2013 HL Liu CH Fan CY Ting and CK Yeh Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors Theranostics Vol 4 No 4 pp432-444 2014 KC Wei PC Chu HYJ Wang CY Huang PY Chen HC Tsai YJ Lu IC Tseng PY Lee TC Yen and HL Liu Focused Ultrasound-induced BloodndashBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment A Preclinical Study PLoS ONE Vol 8 No 3 pp e58995 2013 P-H Hsu K-C Wei C-Y Huang C-J Wen T-C Yen C-L Liu Y-T Lin J-C Chen C-R Shen and H-L Liu Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound PLoS ONE Vol 8 No 2 pp e57682 2013 H-L Liu M-Y Hua H-W Yang C-Y Huang P-C Chu J-S Wua I-C Tseng J-J Wang T-C Yen P-Y Chen and K-C Wei ldquoMagnetic resonance monitoring of focused ultrasoundmagnetic nanoparticle targeting delivery of therapeutic agents to the brainrdquo Proceedings of National Academy of Science USA Vol 107 No 34 pp15205-15210 2010 H-L Liu M-Y Hua P-Y Chen P-C Chu C-H Pan H-W Yang C-Y Huang J-J Wang T-C Yen and K-C Wei ldquoBloodndashBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatmentrdquo Radiology Vol 255 No 2 pp 415-425 2010 H-L Liu Y-Y Wai P-H Hsu L-A Lyu J-S Wu C-R Shen J-C Chen T-C Yen and J-J Wang ldquoIn Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Bloodndashbrain Barrier with Focused Ultrasound A Magnetic Resonance Imaging Studyrdquo Journal of Cerebral Blood Flow amp Metabolism Vol 30 pp 168-177 2010
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
15
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-3 Prof Tzu-Wei Wang
Associate Professor
Department of Materials Science and Engineering and Institute of Biomedical
Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013
Office Delta Teaching Building R434
TEL +886-3-5715131 ext 33856
Email twwangmxnthuedutw Education 2006 PhD Institute of Biomedical Engineering National Taiwan University Taiwan
Professional Experience 2013 ndashpresent Associate Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2009 -2013 Assistant Professor Department of Materials Science and Engineering National Tsing Hua
University Taiwan 2007-2009 Postdoctoral Research Fellow Tissue Engineering Laboratories of Brigham and Womenrsquos
Hospital Harvard Medical School USA
Honor and awards (2009~) Young Plenary Award 2013 TERMIS-AP Symposium Shanghai China (2013) The 9th National Innovation Award Academic Research Category by Institute for Biotechnology and Medicine Industry Taiwan (2012) Young Investigator Award International Symposium of Materials on Regenerative Medicine Taiwan (2012 ISOMRM) Young Investigator Award 5th World Congress on Bioengineering the World Association for Chinese Biomedical Engineers Taiwan (WACBE 2011)
Selected Publication (2012~) Yang CS Wu HC Sun JS Hsiao HM Wang TW Thermo-induced shape memory PEG-PCL copolymer as dual drug-eluting biodegradable stent ACS Appl Mater Interfaces 2013 5 (21) 10985ndash10994 Yeh PH Sun JS Wu HC Hwang LH Wang TW Stimuli-responsive HA-PEI nanoparticles encapsulating endostatin plasmid for stem cell gene therapy RSC Advances 2013 3 (31) 12922 - 12932 Chen YY Wu HC Sun JS Dong GC Wang TW Injectable and thermoresponsive self-assembled nanocomposite hydrogel for long-term anticancer drug delivery Langmuir 201329(11)3721-3729 Cheng TY Wu HC Chang WH Huang MY Lee CH Wang TW Self-assembling functionalized nanopeptides for immediate hemostasis and accelerative liver tissue regeneration Nanoscale 2013 5 (7) 2734 - 2744 Chang YJ Tsai CJ Tseng FG Chen TJ Wang TW Micropatterned Stretching System for the Investigation of Mechanical Tension on Neural Stem Cells Behavior Nanomedicine Nanotechnology Biology and Medicine 20139345-355 Cheng TY Chen MH Chang WH Huang MY Wang TW Neural stem cells encapsulated in a functionalized self-assembling peptide hydrogel for brain tissue engineering Biomaterials 2013 34(8)2005-2016 Goh JH Wu HC Chen MH Chen MY Chang SC Wang TW Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages Acta Biomaterialia 20139(2)5170-5180 Huang YJ Wu HC Tai NH Wang TW Carbon Nanotube Rope with Electrical Stimulation Promotes the Differentiation and Maturity of Neural Stem Cells Small 20128(18) 2869ndash2877
16
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-3 Sep 13 2014 (Sat) 1015-1045 at NTHU BMES R120
Electrospun Composite Nanofibers with Staged Release of Multiple Angiogenic Growth Factors for Chronic Wound Healing
Tzu-Wei Wang
Department of Materials Science and Engineering and Institute of Biomedical Engineering National
Tsing Hua University
The objective of this research study is to develop collagen (Col) and hyaluronic acid (HA)
inter-stacking nanofibrous skin equivalent substitute with programmable release of multiple
angiogenic growth factors (VEGF PDGF bFGF and EGF) either directly embedded in the
nanofibers or encapsulated in the gelatin nanoparticles (GN) by electrospinning technology The
delivery of EGF and bFGF in early stage is expected to accelerate epithelialization and vasculature
sprouting while release of PDGF and VEGF in late stage is aimed for the induction of blood vessels
maturation The physiochemical characterizations report that the Col-HA-GN nanofibrous membrane
possesses mechanical property similar to human native skin The design of particle-in-fiber structure
allows growth factors for slow controlled release up to one month Cultured on biodegradable
Col-HA membrane with four kinds of growth factors (Col-HA w4GF) endothelial cells not only
increase in growth rate but also form better network of thread-like tubular structure Therapeutic
effect of Col-HA w4GF membrane on STZ-induced diabetic rats reveal accelerated wound closure
rate elevated collagen deposition and enhanced mature vessels by Massonrsquos trichrome stain and
immunohistochemical analysis respectively From the above the electrospun Col-HA-GN composite
nanofibrous skin substitute with stage-wise release pattern of multiple angiogenic factors could be a
promising bioengineered construct for the chronic wound healing in skin tissue regeneration
17
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-4 Assistant Prof Ryo Ishihara
Assistant Professor
Department of Materials Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
Tokyo University of Science Research Building 9th floor
TEL +81-3-5876-1415
FAX +81-3-5876-1415
Education 2012 PhD Department of Applied Chemistry and Biotechnology Chiba University Japan 2008 MS Department of Materials Technology Chiba University Japan 2006 BS Department of Materials Technology Chiba University Japan
Professional Experience 2014 ndashpresent Assistant Professor Department of Materials Science and Technology Tokyo
University of Science 2012 ndash2014 Postdoctral Researcher Bioengineering Laboratory RIKEN
Honor and awards Department chairmanlsquos award from Chiba University (2012)
Selected Publication (2010~) Simple Method for High-Density Impregnation of Aliquat 336 onto Porous Sheet and Binding Performance of Resulting Sheet for Palladium Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota Sep Sci Technol 49154-159 (2014) Effect of Dose on Mole Percentage of Polymer Brush and Root Grafted onto Porous Polyethylene Sheet by Radiation-Induced Graft Polymerization R Ishihara S Uchiyama H Ikezawa S Yamada H Hirota D Umeno K Saito Ind Eng Chem Res 5212582-12586 (2013) Determination of Mole Percentages of Brush and Root of Polymer Chain Grafted onto Porous Sheet S Uchiyama R Ishihara D Umeno K Saito S Yamada H Hirota S Asai J Chem Eng Japan 46414-419 (2013) Crosslinked-chelating Porous Sheet with High Dynamic Binding Capacity of Metal Ions G Wada R Ishihara K Miyoshi D Umeno K Saito S Yamada H Hirota Solv Extr Ion Exch 31210-220 (2013) Dependence of Lanthanide-Ion Binding Performance on HDEHP Concentration in HDEHP Impregnation to Porous Sheet R Ishihara S Asai S Otosaka S Yamada H Hirota K Miyoshi D Umeno K Saito Solv Extr Ion Exch 30171-180 (2012) Impregnation of TOPO onto Hydrophobic-Ligand-Containing Porous Sheet and Its Adsorptionelution Performance of Bismuth Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota React Funct Polym 70986-990 (2010)
18
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-4 Sep 13 2014 (Sat) 1110-1140 at NTHU BMES R120
Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip toward Point-of-Care Diagnosis
Ryo Ishihara Kazuo Hosokawa Mizuo Maeda
Bioengineering Laboratory RIKEN
MicroRNAs (miRNAs) are short and non-protein-coding single-stranded RNAs and have shown great promise for
cancer diagnosis Some miRNAs circulate in human body fluid with extremely low concentrations and its expression
profiling can detect and classify cancers in the human body [1] Point-of-care (POC) diagnosis requires short detection
time small required sample volume and portability of the device In various miRNA detection methods microfluidic
chip meets the requirements except the portability Hence we used our power-free pump-free microfluidic chip driven
by energy that is stored in degased PDMS to overcome those drawbacks which eliminates the need for external power
sources for fluid pumping [2] The pump-free pumping method is essential for microfluidic chip-based POC diagnosis In
our laboratory rapid and sensitive singleplex miRNA detection with laminar flow-assisted dendritic amplification (LFDA)
[3] on the pump-free microfluidic chip has been developed [4] In this study rapid and sensitive multiplex miRNA
detection on the pump-free microfluidic chip was demonstrated
Pump-free microchip for multiplex miRNA detection was prepared as follows First the PDMS part with a pair of
Y-shaped microchannels with 100 μm in width and 25 μm in height was fabricated Second three parallel-line-shaped
probe DNAs were patterned onto a glass surface Third the PDMS channels were attached onto the glass plate Finally
the chip was degassed in a vacuum chamber After the chip preparation target miRNAs were detected following three
steps (1) blocking (2) sandwich hybridization of the target miRNAs and biotinylated probe DNAs and (3) signal
amplification by LFDA MiR-16 miR-21-5p and miR-500a-3p were used as target miRNAs since they are known as
cancer biomarkers [5-7] Fluorescence signals were captured by CCD camera and analyzed by the software (ImageJ)
Bright lines appeared at the expected positions they appeared only on the areas with the respective probe DNA in which
the target miRNAs had been supplied These data prove that the LFDA successfully took place in a target
sequence-dependent manner Calibration curves were plotted from the fluorescence signals The data points of the
calibration curve were fitted with the four-parameter logistic function and limit-of-detections (LODs) were evaluated by
the 3σ criterion LODs of the miR-16 miR-21-5p and miR-500a-3p were 68 fM 15 pM and 150 fM respectively The
LODs are on the same order of magnitude as concentrations of miRNA in blood Multiplex detection was verified from
correspondence between the calibration curves of single and multiplex The required sample volume was 05 microL and
assay time was 20 min Because most of the existing methods take more than a few hours the rapidness small required
sample volume and portability of the device are ideal advantages for POC diagnosis
References
[1] PS Mitchell et al PNAS 105 (2008) 10513 [2] K Hosokawa et al Lab Chip 4 (2004) 181 [3] K Hosokawa et al Anal
Chem 79 (2007) 6000 [4] H Arata et al PLoS ONE 7 (2012) e48329 [5] MJ Lodes et al PLoS ONE 4 (2009) e6229
[6] Y Toiyama et al J Natl Cancer Inst 105 (2013) 849 [7] Y Yamamoto et al Biomarkers 14 (2009) 529
19
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-5 Dr Wen-Hsuan Chiang
Assistant Researcher
Department of Biomedical Engineering and Environmental Sciences
National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
TEL (886) 3-571-5131 ext 35576
Education 2009 PhD Department of Chemical Engineering National Chung Hsing University Taiwan Thesis Supervisor Professor Hsin-Cheng Chiu 2002 BS Department of Chemical Engineering Tatung University Taiwan Professional Experience 2013 ndashpresent Assistant Researcher Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University 2010 ndash2012 Postdoctoral Fellow Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
Areas of Research Expertise Biomaterials Smart Amphiphilic Copolymers Multifunctional Nanocarriers for Cancer Therapy and Imaging Nano Science and Interfacial Engineering
Selected Publication (2010~) Wen-Hsuan Chiang Wen-Chia Huang Ming-Yin Shen Che-Hsu Wang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Dual-Layered Nanogel-Coated Hollow LipidPolypeptide Conjugate Assemblies for Potential pH-Triggered Intracellular Drug Release PLOS ONE 2014 9 1-11 Wen-Hsuan Chiang Wen-Chia Huang Chien-Wen Chang Ming-Yin Shen Zong-Fu Shih Yi-Fong Huang Sung-Chyr Lin Hsin-Cheng Chiu Functionalized Polymersomes with Outlayered Polyelectrolyte Gels for Potential Tumor-Targeted Delivery of Multimodal Therapies and MR Imaging Journal of Controlled Release 2013 168 280-288 Wen-Hsuan Chiang Viet Thang Ho Hsin-Hung Chen Wen-Chia Huang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Superparamagnetic Hollow Hybrid Nanogels as a Potential Guidable Vehicle System of Stimuli-Mediated MR Imaging and Multiple Cancer Therapeutics Langmuir 2013 29 6434-6443 Wen-Hsuan Chiang Viet Thang Ho Wen-Chia Huang Yi-Fong Huang Chorng-Shyan Chern Hsin-Cheng Chiu Dual Stimuli-Responsive Polymeric Hollow Nanogels Designed as Carriers for Intracellular Triggered Drug Release Langmuir 2012 28 15056-15064 Yi-Fong HuangDagger Wen-Hsuan ChiangDagger Pei-Ling Tsai Chorng-Shyan Chern Hsin-Cheng Chiu Novel Hybrid Vesicles Co-Assembled from Cationic Lipid and PAAc-g-mPEG with pH-Triggered Transmembrane Channels for Controlled Drug Release Chemical Communications 2011 47 10978-10980
20
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-5 Sep 13 2014 (Sat) 1140-1210 at NTHU BMES R120 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and Imaging
Applications
Wen-Hsuan Chiang
Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
In order to promote therapeutic efficacy and minimize side effect equipping these nanocarriers with the
capability of controlling drug release in response to an appropriate stimulus is essentially required Acidic pH
as an internal stimulus is particular appealing because of the mildly acid pH encountered in tumor tissues and
the intracellular compartments such as endosomes and lysosomes Therefore the pH-responsive drug carriers
have been extensively developed for improving intracellular drug delivery To realize the pH-responsive drug
release we adopted a simple approach to design the lipidPEG-containing complex vesicles with pH-triggered
transmembrane channels as a chemotherapy drug doxorubicin (DOX) delivery carrier In this study the
complex vesicles were attained by spontaneous co-assembly of poly(acrylic acid)-g-poly(monomethoxy
ethylene glycol) (PAAc-g-mPEG) with a cationic lipid didodecyldimethylammonium bromide (DDAB) in
aqueous phase of pH 89 via electrostatic interactions Through the formation of unionized AAc-rich
transmembrance channels of complex vesicles in weak acidic environments the acid-triggered rapid drug
release can be achieved
On the other hand for simultaneously monitoring disease progression and biological response after
treatments we developed a novel tumor-targeting polymersome system capable of delivering magnetic
resonance imaging (MRI) and chemotherapy The DOX-loaded magnetic polymersomes were first attained by
the self-assembly of lipid-containing copolymer poly(AAc-co-distearin acrylate) in aqueous solution
containing citric acid-coated superparamagnetic iron oxide nanoparticles (SPIONs) and followed by DOX
loading via electrostatic attraction To further functionalize these vesicles with superior in vivo colloidal
stability pH-tunable drug release and active tumor-targeting chitosan and poly( -glutamic
acid-co- -glutamyl oxysuccinimide)-g-PEG-folate (FA) were deposited in sequence onto the assembly outer
surfaces The interfacial nanogel layers via electrostatic interactions and in-situ covalent cross-linking were
thus produced Triggerable release of the encapsulated DOX was governed by dual external stimuli pH and
temperature When these theranostic NCPs were effectively internalized by HeLa cells via FA
receptor-mediated endocytosis and then exposed to high frequency magnetic fields (HFMF) the combined
effects of both pH and magnetic hyperthermia-triggered drug release and thermo-therapy resulted in greater
cytotoxicity than the treatment by DOX alone By virtue of the SPION clustering effect in the assembly inner
aqueous compartments the SPIONDOX-loaded NCPs displayed an r2 relaxivity value higher than Resovist
a commercial SPION-based T2 contrast agent The high magnetic relaxivity of the tumor-targeting NCPs
coupled with their enhanced cellular uptake considerably promoted the MRI contrast of targeted cancer cells
These results demonstrate the great potential of the FA-decorated SPIONDOX-loaded NCPs as an advanced
cancer theranostic nanodevice
21
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-1 Prof Hao-Li Liu Professor and Director
Department of Electrical Engineering
Chang Gung University
Phone +886-3-2118800 ext 5677
Fax +886-3-2118026
E-mail haoliliumailcguedutw
Education 2003 PhD National Taiwan University Taipei TAIWAN 1998 M S National Taiwan University Taipei TAIWAN 1996 B S National Taipei University of Technology TAIWAN
Professional Experience 2012-present Director Dept of Electrical Engineering Chang Gung Univ Taiwan 2011-present Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2008 Associate Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2005 ndash2008 Assistant Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2004 ndash2005 Research Fellow Department of Radiology Brigham amp Womenrsquos Hospital Harvard Medical School MA USA
Honor and awards (2009~) 2013 Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) 2013 The 2013 Frederick Lizzi Award International Society of Therapeutic Ultrasound 2011 Distinguished Tech-Coop Award (長庚大學優良教師技合獎) Chang-Gung University 2011 Wu Ta-You Memorial Award (吳大猷先生紀念獎) National Science Council Taiwan 2011 2010 Distinguished Research Award (長庚大學優良教師研究獎) Chang-Gung University
Selected Publication (2010~) HW Yang MY Hua TL Hwang KJ Lin CY Huang RY Tsai CCM Ma PH Hsu SP Wey PW Hsu PY Chen YC Huang YJ Lu TC Yen LY Feng CW Lin HL Liu KC Wei Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide Advanced Materials Vol 25 No 26 pp3605-3611 2013 HL Liu CH Fan CY Ting and CK Yeh Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors Theranostics Vol 4 No 4 pp432-444 2014 KC Wei PC Chu HYJ Wang CY Huang PY Chen HC Tsai YJ Lu IC Tseng PY Lee TC Yen and HL Liu Focused Ultrasound-induced BloodndashBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment A Preclinical Study PLoS ONE Vol 8 No 3 pp e58995 2013 P-H Hsu K-C Wei C-Y Huang C-J Wen T-C Yen C-L Liu Y-T Lin J-C Chen C-R Shen and H-L Liu Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound PLoS ONE Vol 8 No 2 pp e57682 2013 H-L Liu M-Y Hua H-W Yang C-Y Huang P-C Chu J-S Wua I-C Tseng J-J Wang T-C Yen P-Y Chen and K-C Wei ldquoMagnetic resonance monitoring of focused ultrasoundmagnetic nanoparticle targeting delivery of therapeutic agents to the brainrdquo Proceedings of National Academy of Science USA Vol 107 No 34 pp15205-15210 2010 H-L Liu M-Y Hua P-Y Chen P-C Chu C-H Pan H-W Yang C-Y Huang J-J Wang T-C Yen and K-C Wei ldquoBloodndashBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatmentrdquo Radiology Vol 255 No 2 pp 415-425 2010 H-L Liu Y-Y Wai P-H Hsu L-A Lyu J-S Wu C-R Shen J-C Chen T-C Yen and J-J Wang ldquoIn Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Bloodndashbrain Barrier with Focused Ultrasound A Magnetic Resonance Imaging Studyrdquo Journal of Cerebral Blood Flow amp Metabolism Vol 30 pp 168-177 2010
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
16
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-3 Sep 13 2014 (Sat) 1015-1045 at NTHU BMES R120
Electrospun Composite Nanofibers with Staged Release of Multiple Angiogenic Growth Factors for Chronic Wound Healing
Tzu-Wei Wang
Department of Materials Science and Engineering and Institute of Biomedical Engineering National
Tsing Hua University
The objective of this research study is to develop collagen (Col) and hyaluronic acid (HA)
inter-stacking nanofibrous skin equivalent substitute with programmable release of multiple
angiogenic growth factors (VEGF PDGF bFGF and EGF) either directly embedded in the
nanofibers or encapsulated in the gelatin nanoparticles (GN) by electrospinning technology The
delivery of EGF and bFGF in early stage is expected to accelerate epithelialization and vasculature
sprouting while release of PDGF and VEGF in late stage is aimed for the induction of blood vessels
maturation The physiochemical characterizations report that the Col-HA-GN nanofibrous membrane
possesses mechanical property similar to human native skin The design of particle-in-fiber structure
allows growth factors for slow controlled release up to one month Cultured on biodegradable
Col-HA membrane with four kinds of growth factors (Col-HA w4GF) endothelial cells not only
increase in growth rate but also form better network of thread-like tubular structure Therapeutic
effect of Col-HA w4GF membrane on STZ-induced diabetic rats reveal accelerated wound closure
rate elevated collagen deposition and enhanced mature vessels by Massonrsquos trichrome stain and
immunohistochemical analysis respectively From the above the electrospun Col-HA-GN composite
nanofibrous skin substitute with stage-wise release pattern of multiple angiogenic factors could be a
promising bioengineered construct for the chronic wound healing in skin tissue regeneration
17
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-4 Assistant Prof Ryo Ishihara
Assistant Professor
Department of Materials Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
Tokyo University of Science Research Building 9th floor
TEL +81-3-5876-1415
FAX +81-3-5876-1415
Education 2012 PhD Department of Applied Chemistry and Biotechnology Chiba University Japan 2008 MS Department of Materials Technology Chiba University Japan 2006 BS Department of Materials Technology Chiba University Japan
Professional Experience 2014 ndashpresent Assistant Professor Department of Materials Science and Technology Tokyo
University of Science 2012 ndash2014 Postdoctral Researcher Bioengineering Laboratory RIKEN
Honor and awards Department chairmanlsquos award from Chiba University (2012)
Selected Publication (2010~) Simple Method for High-Density Impregnation of Aliquat 336 onto Porous Sheet and Binding Performance of Resulting Sheet for Palladium Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota Sep Sci Technol 49154-159 (2014) Effect of Dose on Mole Percentage of Polymer Brush and Root Grafted onto Porous Polyethylene Sheet by Radiation-Induced Graft Polymerization R Ishihara S Uchiyama H Ikezawa S Yamada H Hirota D Umeno K Saito Ind Eng Chem Res 5212582-12586 (2013) Determination of Mole Percentages of Brush and Root of Polymer Chain Grafted onto Porous Sheet S Uchiyama R Ishihara D Umeno K Saito S Yamada H Hirota S Asai J Chem Eng Japan 46414-419 (2013) Crosslinked-chelating Porous Sheet with High Dynamic Binding Capacity of Metal Ions G Wada R Ishihara K Miyoshi D Umeno K Saito S Yamada H Hirota Solv Extr Ion Exch 31210-220 (2013) Dependence of Lanthanide-Ion Binding Performance on HDEHP Concentration in HDEHP Impregnation to Porous Sheet R Ishihara S Asai S Otosaka S Yamada H Hirota K Miyoshi D Umeno K Saito Solv Extr Ion Exch 30171-180 (2012) Impregnation of TOPO onto Hydrophobic-Ligand-Containing Porous Sheet and Its Adsorptionelution Performance of Bismuth Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota React Funct Polym 70986-990 (2010)
18
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-4 Sep 13 2014 (Sat) 1110-1140 at NTHU BMES R120
Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip toward Point-of-Care Diagnosis
Ryo Ishihara Kazuo Hosokawa Mizuo Maeda
Bioengineering Laboratory RIKEN
MicroRNAs (miRNAs) are short and non-protein-coding single-stranded RNAs and have shown great promise for
cancer diagnosis Some miRNAs circulate in human body fluid with extremely low concentrations and its expression
profiling can detect and classify cancers in the human body [1] Point-of-care (POC) diagnosis requires short detection
time small required sample volume and portability of the device In various miRNA detection methods microfluidic
chip meets the requirements except the portability Hence we used our power-free pump-free microfluidic chip driven
by energy that is stored in degased PDMS to overcome those drawbacks which eliminates the need for external power
sources for fluid pumping [2] The pump-free pumping method is essential for microfluidic chip-based POC diagnosis In
our laboratory rapid and sensitive singleplex miRNA detection with laminar flow-assisted dendritic amplification (LFDA)
[3] on the pump-free microfluidic chip has been developed [4] In this study rapid and sensitive multiplex miRNA
detection on the pump-free microfluidic chip was demonstrated
Pump-free microchip for multiplex miRNA detection was prepared as follows First the PDMS part with a pair of
Y-shaped microchannels with 100 μm in width and 25 μm in height was fabricated Second three parallel-line-shaped
probe DNAs were patterned onto a glass surface Third the PDMS channels were attached onto the glass plate Finally
the chip was degassed in a vacuum chamber After the chip preparation target miRNAs were detected following three
steps (1) blocking (2) sandwich hybridization of the target miRNAs and biotinylated probe DNAs and (3) signal
amplification by LFDA MiR-16 miR-21-5p and miR-500a-3p were used as target miRNAs since they are known as
cancer biomarkers [5-7] Fluorescence signals were captured by CCD camera and analyzed by the software (ImageJ)
Bright lines appeared at the expected positions they appeared only on the areas with the respective probe DNA in which
the target miRNAs had been supplied These data prove that the LFDA successfully took place in a target
sequence-dependent manner Calibration curves were plotted from the fluorescence signals The data points of the
calibration curve were fitted with the four-parameter logistic function and limit-of-detections (LODs) were evaluated by
the 3σ criterion LODs of the miR-16 miR-21-5p and miR-500a-3p were 68 fM 15 pM and 150 fM respectively The
LODs are on the same order of magnitude as concentrations of miRNA in blood Multiplex detection was verified from
correspondence between the calibration curves of single and multiplex The required sample volume was 05 microL and
assay time was 20 min Because most of the existing methods take more than a few hours the rapidness small required
sample volume and portability of the device are ideal advantages for POC diagnosis
References
[1] PS Mitchell et al PNAS 105 (2008) 10513 [2] K Hosokawa et al Lab Chip 4 (2004) 181 [3] K Hosokawa et al Anal
Chem 79 (2007) 6000 [4] H Arata et al PLoS ONE 7 (2012) e48329 [5] MJ Lodes et al PLoS ONE 4 (2009) e6229
[6] Y Toiyama et al J Natl Cancer Inst 105 (2013) 849 [7] Y Yamamoto et al Biomarkers 14 (2009) 529
19
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-5 Dr Wen-Hsuan Chiang
Assistant Researcher
Department of Biomedical Engineering and Environmental Sciences
National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
TEL (886) 3-571-5131 ext 35576
Education 2009 PhD Department of Chemical Engineering National Chung Hsing University Taiwan Thesis Supervisor Professor Hsin-Cheng Chiu 2002 BS Department of Chemical Engineering Tatung University Taiwan Professional Experience 2013 ndashpresent Assistant Researcher Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University 2010 ndash2012 Postdoctoral Fellow Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
Areas of Research Expertise Biomaterials Smart Amphiphilic Copolymers Multifunctional Nanocarriers for Cancer Therapy and Imaging Nano Science and Interfacial Engineering
Selected Publication (2010~) Wen-Hsuan Chiang Wen-Chia Huang Ming-Yin Shen Che-Hsu Wang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Dual-Layered Nanogel-Coated Hollow LipidPolypeptide Conjugate Assemblies for Potential pH-Triggered Intracellular Drug Release PLOS ONE 2014 9 1-11 Wen-Hsuan Chiang Wen-Chia Huang Chien-Wen Chang Ming-Yin Shen Zong-Fu Shih Yi-Fong Huang Sung-Chyr Lin Hsin-Cheng Chiu Functionalized Polymersomes with Outlayered Polyelectrolyte Gels for Potential Tumor-Targeted Delivery of Multimodal Therapies and MR Imaging Journal of Controlled Release 2013 168 280-288 Wen-Hsuan Chiang Viet Thang Ho Hsin-Hung Chen Wen-Chia Huang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Superparamagnetic Hollow Hybrid Nanogels as a Potential Guidable Vehicle System of Stimuli-Mediated MR Imaging and Multiple Cancer Therapeutics Langmuir 2013 29 6434-6443 Wen-Hsuan Chiang Viet Thang Ho Wen-Chia Huang Yi-Fong Huang Chorng-Shyan Chern Hsin-Cheng Chiu Dual Stimuli-Responsive Polymeric Hollow Nanogels Designed as Carriers for Intracellular Triggered Drug Release Langmuir 2012 28 15056-15064 Yi-Fong HuangDagger Wen-Hsuan ChiangDagger Pei-Ling Tsai Chorng-Shyan Chern Hsin-Cheng Chiu Novel Hybrid Vesicles Co-Assembled from Cationic Lipid and PAAc-g-mPEG with pH-Triggered Transmembrane Channels for Controlled Drug Release Chemical Communications 2011 47 10978-10980
20
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-5 Sep 13 2014 (Sat) 1140-1210 at NTHU BMES R120 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and Imaging
Applications
Wen-Hsuan Chiang
Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
In order to promote therapeutic efficacy and minimize side effect equipping these nanocarriers with the
capability of controlling drug release in response to an appropriate stimulus is essentially required Acidic pH
as an internal stimulus is particular appealing because of the mildly acid pH encountered in tumor tissues and
the intracellular compartments such as endosomes and lysosomes Therefore the pH-responsive drug carriers
have been extensively developed for improving intracellular drug delivery To realize the pH-responsive drug
release we adopted a simple approach to design the lipidPEG-containing complex vesicles with pH-triggered
transmembrane channels as a chemotherapy drug doxorubicin (DOX) delivery carrier In this study the
complex vesicles were attained by spontaneous co-assembly of poly(acrylic acid)-g-poly(monomethoxy
ethylene glycol) (PAAc-g-mPEG) with a cationic lipid didodecyldimethylammonium bromide (DDAB) in
aqueous phase of pH 89 via electrostatic interactions Through the formation of unionized AAc-rich
transmembrance channels of complex vesicles in weak acidic environments the acid-triggered rapid drug
release can be achieved
On the other hand for simultaneously monitoring disease progression and biological response after
treatments we developed a novel tumor-targeting polymersome system capable of delivering magnetic
resonance imaging (MRI) and chemotherapy The DOX-loaded magnetic polymersomes were first attained by
the self-assembly of lipid-containing copolymer poly(AAc-co-distearin acrylate) in aqueous solution
containing citric acid-coated superparamagnetic iron oxide nanoparticles (SPIONs) and followed by DOX
loading via electrostatic attraction To further functionalize these vesicles with superior in vivo colloidal
stability pH-tunable drug release and active tumor-targeting chitosan and poly( -glutamic
acid-co- -glutamyl oxysuccinimide)-g-PEG-folate (FA) were deposited in sequence onto the assembly outer
surfaces The interfacial nanogel layers via electrostatic interactions and in-situ covalent cross-linking were
thus produced Triggerable release of the encapsulated DOX was governed by dual external stimuli pH and
temperature When these theranostic NCPs were effectively internalized by HeLa cells via FA
receptor-mediated endocytosis and then exposed to high frequency magnetic fields (HFMF) the combined
effects of both pH and magnetic hyperthermia-triggered drug release and thermo-therapy resulted in greater
cytotoxicity than the treatment by DOX alone By virtue of the SPION clustering effect in the assembly inner
aqueous compartments the SPIONDOX-loaded NCPs displayed an r2 relaxivity value higher than Resovist
a commercial SPION-based T2 contrast agent The high magnetic relaxivity of the tumor-targeting NCPs
coupled with their enhanced cellular uptake considerably promoted the MRI contrast of targeted cancer cells
These results demonstrate the great potential of the FA-decorated SPIONDOX-loaded NCPs as an advanced
cancer theranostic nanodevice
21
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-1 Prof Hao-Li Liu Professor and Director
Department of Electrical Engineering
Chang Gung University
Phone +886-3-2118800 ext 5677
Fax +886-3-2118026
E-mail haoliliumailcguedutw
Education 2003 PhD National Taiwan University Taipei TAIWAN 1998 M S National Taiwan University Taipei TAIWAN 1996 B S National Taipei University of Technology TAIWAN
Professional Experience 2012-present Director Dept of Electrical Engineering Chang Gung Univ Taiwan 2011-present Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2008 Associate Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2005 ndash2008 Assistant Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2004 ndash2005 Research Fellow Department of Radiology Brigham amp Womenrsquos Hospital Harvard Medical School MA USA
Honor and awards (2009~) 2013 Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) 2013 The 2013 Frederick Lizzi Award International Society of Therapeutic Ultrasound 2011 Distinguished Tech-Coop Award (長庚大學優良教師技合獎) Chang-Gung University 2011 Wu Ta-You Memorial Award (吳大猷先生紀念獎) National Science Council Taiwan 2011 2010 Distinguished Research Award (長庚大學優良教師研究獎) Chang-Gung University
Selected Publication (2010~) HW Yang MY Hua TL Hwang KJ Lin CY Huang RY Tsai CCM Ma PH Hsu SP Wey PW Hsu PY Chen YC Huang YJ Lu TC Yen LY Feng CW Lin HL Liu KC Wei Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide Advanced Materials Vol 25 No 26 pp3605-3611 2013 HL Liu CH Fan CY Ting and CK Yeh Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors Theranostics Vol 4 No 4 pp432-444 2014 KC Wei PC Chu HYJ Wang CY Huang PY Chen HC Tsai YJ Lu IC Tseng PY Lee TC Yen and HL Liu Focused Ultrasound-induced BloodndashBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment A Preclinical Study PLoS ONE Vol 8 No 3 pp e58995 2013 P-H Hsu K-C Wei C-Y Huang C-J Wen T-C Yen C-L Liu Y-T Lin J-C Chen C-R Shen and H-L Liu Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound PLoS ONE Vol 8 No 2 pp e57682 2013 H-L Liu M-Y Hua H-W Yang C-Y Huang P-C Chu J-S Wua I-C Tseng J-J Wang T-C Yen P-Y Chen and K-C Wei ldquoMagnetic resonance monitoring of focused ultrasoundmagnetic nanoparticle targeting delivery of therapeutic agents to the brainrdquo Proceedings of National Academy of Science USA Vol 107 No 34 pp15205-15210 2010 H-L Liu M-Y Hua P-Y Chen P-C Chu C-H Pan H-W Yang C-Y Huang J-J Wang T-C Yen and K-C Wei ldquoBloodndashBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatmentrdquo Radiology Vol 255 No 2 pp 415-425 2010 H-L Liu Y-Y Wai P-H Hsu L-A Lyu J-S Wu C-R Shen J-C Chen T-C Yen and J-J Wang ldquoIn Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Bloodndashbrain Barrier with Focused Ultrasound A Magnetic Resonance Imaging Studyrdquo Journal of Cerebral Blood Flow amp Metabolism Vol 30 pp 168-177 2010
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
17
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-4 Assistant Prof Ryo Ishihara
Assistant Professor
Department of Materials Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
Tokyo University of Science Research Building 9th floor
TEL +81-3-5876-1415
FAX +81-3-5876-1415
Education 2012 PhD Department of Applied Chemistry and Biotechnology Chiba University Japan 2008 MS Department of Materials Technology Chiba University Japan 2006 BS Department of Materials Technology Chiba University Japan
Professional Experience 2014 ndashpresent Assistant Professor Department of Materials Science and Technology Tokyo
University of Science 2012 ndash2014 Postdoctral Researcher Bioengineering Laboratory RIKEN
Honor and awards Department chairmanlsquos award from Chiba University (2012)
Selected Publication (2010~) Simple Method for High-Density Impregnation of Aliquat 336 onto Porous Sheet and Binding Performance of Resulting Sheet for Palladium Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota Sep Sci Technol 49154-159 (2014) Effect of Dose on Mole Percentage of Polymer Brush and Root Grafted onto Porous Polyethylene Sheet by Radiation-Induced Graft Polymerization R Ishihara S Uchiyama H Ikezawa S Yamada H Hirota D Umeno K Saito Ind Eng Chem Res 5212582-12586 (2013) Determination of Mole Percentages of Brush and Root of Polymer Chain Grafted onto Porous Sheet S Uchiyama R Ishihara D Umeno K Saito S Yamada H Hirota S Asai J Chem Eng Japan 46414-419 (2013) Crosslinked-chelating Porous Sheet with High Dynamic Binding Capacity of Metal Ions G Wada R Ishihara K Miyoshi D Umeno K Saito S Yamada H Hirota Solv Extr Ion Exch 31210-220 (2013) Dependence of Lanthanide-Ion Binding Performance on HDEHP Concentration in HDEHP Impregnation to Porous Sheet R Ishihara S Asai S Otosaka S Yamada H Hirota K Miyoshi D Umeno K Saito Solv Extr Ion Exch 30171-180 (2012) Impregnation of TOPO onto Hydrophobic-Ligand-Containing Porous Sheet and Its Adsorptionelution Performance of Bismuth Ions R Tanaka R Ishihara K Miyoshi D Umeno K Saito S Asai S Yamada H Hirota React Funct Polym 70986-990 (2010)
18
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-4 Sep 13 2014 (Sat) 1110-1140 at NTHU BMES R120
Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip toward Point-of-Care Diagnosis
Ryo Ishihara Kazuo Hosokawa Mizuo Maeda
Bioengineering Laboratory RIKEN
MicroRNAs (miRNAs) are short and non-protein-coding single-stranded RNAs and have shown great promise for
cancer diagnosis Some miRNAs circulate in human body fluid with extremely low concentrations and its expression
profiling can detect and classify cancers in the human body [1] Point-of-care (POC) diagnosis requires short detection
time small required sample volume and portability of the device In various miRNA detection methods microfluidic
chip meets the requirements except the portability Hence we used our power-free pump-free microfluidic chip driven
by energy that is stored in degased PDMS to overcome those drawbacks which eliminates the need for external power
sources for fluid pumping [2] The pump-free pumping method is essential for microfluidic chip-based POC diagnosis In
our laboratory rapid and sensitive singleplex miRNA detection with laminar flow-assisted dendritic amplification (LFDA)
[3] on the pump-free microfluidic chip has been developed [4] In this study rapid and sensitive multiplex miRNA
detection on the pump-free microfluidic chip was demonstrated
Pump-free microchip for multiplex miRNA detection was prepared as follows First the PDMS part with a pair of
Y-shaped microchannels with 100 μm in width and 25 μm in height was fabricated Second three parallel-line-shaped
probe DNAs were patterned onto a glass surface Third the PDMS channels were attached onto the glass plate Finally
the chip was degassed in a vacuum chamber After the chip preparation target miRNAs were detected following three
steps (1) blocking (2) sandwich hybridization of the target miRNAs and biotinylated probe DNAs and (3) signal
amplification by LFDA MiR-16 miR-21-5p and miR-500a-3p were used as target miRNAs since they are known as
cancer biomarkers [5-7] Fluorescence signals were captured by CCD camera and analyzed by the software (ImageJ)
Bright lines appeared at the expected positions they appeared only on the areas with the respective probe DNA in which
the target miRNAs had been supplied These data prove that the LFDA successfully took place in a target
sequence-dependent manner Calibration curves were plotted from the fluorescence signals The data points of the
calibration curve were fitted with the four-parameter logistic function and limit-of-detections (LODs) were evaluated by
the 3σ criterion LODs of the miR-16 miR-21-5p and miR-500a-3p were 68 fM 15 pM and 150 fM respectively The
LODs are on the same order of magnitude as concentrations of miRNA in blood Multiplex detection was verified from
correspondence between the calibration curves of single and multiplex The required sample volume was 05 microL and
assay time was 20 min Because most of the existing methods take more than a few hours the rapidness small required
sample volume and portability of the device are ideal advantages for POC diagnosis
References
[1] PS Mitchell et al PNAS 105 (2008) 10513 [2] K Hosokawa et al Lab Chip 4 (2004) 181 [3] K Hosokawa et al Anal
Chem 79 (2007) 6000 [4] H Arata et al PLoS ONE 7 (2012) e48329 [5] MJ Lodes et al PLoS ONE 4 (2009) e6229
[6] Y Toiyama et al J Natl Cancer Inst 105 (2013) 849 [7] Y Yamamoto et al Biomarkers 14 (2009) 529
19
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-5 Dr Wen-Hsuan Chiang
Assistant Researcher
Department of Biomedical Engineering and Environmental Sciences
National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
TEL (886) 3-571-5131 ext 35576
Education 2009 PhD Department of Chemical Engineering National Chung Hsing University Taiwan Thesis Supervisor Professor Hsin-Cheng Chiu 2002 BS Department of Chemical Engineering Tatung University Taiwan Professional Experience 2013 ndashpresent Assistant Researcher Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University 2010 ndash2012 Postdoctoral Fellow Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
Areas of Research Expertise Biomaterials Smart Amphiphilic Copolymers Multifunctional Nanocarriers for Cancer Therapy and Imaging Nano Science and Interfacial Engineering
Selected Publication (2010~) Wen-Hsuan Chiang Wen-Chia Huang Ming-Yin Shen Che-Hsu Wang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Dual-Layered Nanogel-Coated Hollow LipidPolypeptide Conjugate Assemblies for Potential pH-Triggered Intracellular Drug Release PLOS ONE 2014 9 1-11 Wen-Hsuan Chiang Wen-Chia Huang Chien-Wen Chang Ming-Yin Shen Zong-Fu Shih Yi-Fong Huang Sung-Chyr Lin Hsin-Cheng Chiu Functionalized Polymersomes with Outlayered Polyelectrolyte Gels for Potential Tumor-Targeted Delivery of Multimodal Therapies and MR Imaging Journal of Controlled Release 2013 168 280-288 Wen-Hsuan Chiang Viet Thang Ho Hsin-Hung Chen Wen-Chia Huang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Superparamagnetic Hollow Hybrid Nanogels as a Potential Guidable Vehicle System of Stimuli-Mediated MR Imaging and Multiple Cancer Therapeutics Langmuir 2013 29 6434-6443 Wen-Hsuan Chiang Viet Thang Ho Wen-Chia Huang Yi-Fong Huang Chorng-Shyan Chern Hsin-Cheng Chiu Dual Stimuli-Responsive Polymeric Hollow Nanogels Designed as Carriers for Intracellular Triggered Drug Release Langmuir 2012 28 15056-15064 Yi-Fong HuangDagger Wen-Hsuan ChiangDagger Pei-Ling Tsai Chorng-Shyan Chern Hsin-Cheng Chiu Novel Hybrid Vesicles Co-Assembled from Cationic Lipid and PAAc-g-mPEG with pH-Triggered Transmembrane Channels for Controlled Drug Release Chemical Communications 2011 47 10978-10980
20
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-5 Sep 13 2014 (Sat) 1140-1210 at NTHU BMES R120 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and Imaging
Applications
Wen-Hsuan Chiang
Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
In order to promote therapeutic efficacy and minimize side effect equipping these nanocarriers with the
capability of controlling drug release in response to an appropriate stimulus is essentially required Acidic pH
as an internal stimulus is particular appealing because of the mildly acid pH encountered in tumor tissues and
the intracellular compartments such as endosomes and lysosomes Therefore the pH-responsive drug carriers
have been extensively developed for improving intracellular drug delivery To realize the pH-responsive drug
release we adopted a simple approach to design the lipidPEG-containing complex vesicles with pH-triggered
transmembrane channels as a chemotherapy drug doxorubicin (DOX) delivery carrier In this study the
complex vesicles were attained by spontaneous co-assembly of poly(acrylic acid)-g-poly(monomethoxy
ethylene glycol) (PAAc-g-mPEG) with a cationic lipid didodecyldimethylammonium bromide (DDAB) in
aqueous phase of pH 89 via electrostatic interactions Through the formation of unionized AAc-rich
transmembrance channels of complex vesicles in weak acidic environments the acid-triggered rapid drug
release can be achieved
On the other hand for simultaneously monitoring disease progression and biological response after
treatments we developed a novel tumor-targeting polymersome system capable of delivering magnetic
resonance imaging (MRI) and chemotherapy The DOX-loaded magnetic polymersomes were first attained by
the self-assembly of lipid-containing copolymer poly(AAc-co-distearin acrylate) in aqueous solution
containing citric acid-coated superparamagnetic iron oxide nanoparticles (SPIONs) and followed by DOX
loading via electrostatic attraction To further functionalize these vesicles with superior in vivo colloidal
stability pH-tunable drug release and active tumor-targeting chitosan and poly( -glutamic
acid-co- -glutamyl oxysuccinimide)-g-PEG-folate (FA) were deposited in sequence onto the assembly outer
surfaces The interfacial nanogel layers via electrostatic interactions and in-situ covalent cross-linking were
thus produced Triggerable release of the encapsulated DOX was governed by dual external stimuli pH and
temperature When these theranostic NCPs were effectively internalized by HeLa cells via FA
receptor-mediated endocytosis and then exposed to high frequency magnetic fields (HFMF) the combined
effects of both pH and magnetic hyperthermia-triggered drug release and thermo-therapy resulted in greater
cytotoxicity than the treatment by DOX alone By virtue of the SPION clustering effect in the assembly inner
aqueous compartments the SPIONDOX-loaded NCPs displayed an r2 relaxivity value higher than Resovist
a commercial SPION-based T2 contrast agent The high magnetic relaxivity of the tumor-targeting NCPs
coupled with their enhanced cellular uptake considerably promoted the MRI contrast of targeted cancer cells
These results demonstrate the great potential of the FA-decorated SPIONDOX-loaded NCPs as an advanced
cancer theranostic nanodevice
21
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-1 Prof Hao-Li Liu Professor and Director
Department of Electrical Engineering
Chang Gung University
Phone +886-3-2118800 ext 5677
Fax +886-3-2118026
E-mail haoliliumailcguedutw
Education 2003 PhD National Taiwan University Taipei TAIWAN 1998 M S National Taiwan University Taipei TAIWAN 1996 B S National Taipei University of Technology TAIWAN
Professional Experience 2012-present Director Dept of Electrical Engineering Chang Gung Univ Taiwan 2011-present Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2008 Associate Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2005 ndash2008 Assistant Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2004 ndash2005 Research Fellow Department of Radiology Brigham amp Womenrsquos Hospital Harvard Medical School MA USA
Honor and awards (2009~) 2013 Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) 2013 The 2013 Frederick Lizzi Award International Society of Therapeutic Ultrasound 2011 Distinguished Tech-Coop Award (長庚大學優良教師技合獎) Chang-Gung University 2011 Wu Ta-You Memorial Award (吳大猷先生紀念獎) National Science Council Taiwan 2011 2010 Distinguished Research Award (長庚大學優良教師研究獎) Chang-Gung University
Selected Publication (2010~) HW Yang MY Hua TL Hwang KJ Lin CY Huang RY Tsai CCM Ma PH Hsu SP Wey PW Hsu PY Chen YC Huang YJ Lu TC Yen LY Feng CW Lin HL Liu KC Wei Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide Advanced Materials Vol 25 No 26 pp3605-3611 2013 HL Liu CH Fan CY Ting and CK Yeh Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors Theranostics Vol 4 No 4 pp432-444 2014 KC Wei PC Chu HYJ Wang CY Huang PY Chen HC Tsai YJ Lu IC Tseng PY Lee TC Yen and HL Liu Focused Ultrasound-induced BloodndashBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment A Preclinical Study PLoS ONE Vol 8 No 3 pp e58995 2013 P-H Hsu K-C Wei C-Y Huang C-J Wen T-C Yen C-L Liu Y-T Lin J-C Chen C-R Shen and H-L Liu Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound PLoS ONE Vol 8 No 2 pp e57682 2013 H-L Liu M-Y Hua H-W Yang C-Y Huang P-C Chu J-S Wua I-C Tseng J-J Wang T-C Yen P-Y Chen and K-C Wei ldquoMagnetic resonance monitoring of focused ultrasoundmagnetic nanoparticle targeting delivery of therapeutic agents to the brainrdquo Proceedings of National Academy of Science USA Vol 107 No 34 pp15205-15210 2010 H-L Liu M-Y Hua P-Y Chen P-C Chu C-H Pan H-W Yang C-Y Huang J-J Wang T-C Yen and K-C Wei ldquoBloodndashBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatmentrdquo Radiology Vol 255 No 2 pp 415-425 2010 H-L Liu Y-Y Wai P-H Hsu L-A Lyu J-S Wu C-R Shen J-C Chen T-C Yen and J-J Wang ldquoIn Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Bloodndashbrain Barrier with Focused Ultrasound A Magnetic Resonance Imaging Studyrdquo Journal of Cerebral Blood Flow amp Metabolism Vol 30 pp 168-177 2010
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
18
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-4 Sep 13 2014 (Sat) 1110-1140 at NTHU BMES R120
Multiplex MicroRNA Detection on Pump-Free Microfluidic Chip toward Point-of-Care Diagnosis
Ryo Ishihara Kazuo Hosokawa Mizuo Maeda
Bioengineering Laboratory RIKEN
MicroRNAs (miRNAs) are short and non-protein-coding single-stranded RNAs and have shown great promise for
cancer diagnosis Some miRNAs circulate in human body fluid with extremely low concentrations and its expression
profiling can detect and classify cancers in the human body [1] Point-of-care (POC) diagnosis requires short detection
time small required sample volume and portability of the device In various miRNA detection methods microfluidic
chip meets the requirements except the portability Hence we used our power-free pump-free microfluidic chip driven
by energy that is stored in degased PDMS to overcome those drawbacks which eliminates the need for external power
sources for fluid pumping [2] The pump-free pumping method is essential for microfluidic chip-based POC diagnosis In
our laboratory rapid and sensitive singleplex miRNA detection with laminar flow-assisted dendritic amplification (LFDA)
[3] on the pump-free microfluidic chip has been developed [4] In this study rapid and sensitive multiplex miRNA
detection on the pump-free microfluidic chip was demonstrated
Pump-free microchip for multiplex miRNA detection was prepared as follows First the PDMS part with a pair of
Y-shaped microchannels with 100 μm in width and 25 μm in height was fabricated Second three parallel-line-shaped
probe DNAs were patterned onto a glass surface Third the PDMS channels were attached onto the glass plate Finally
the chip was degassed in a vacuum chamber After the chip preparation target miRNAs were detected following three
steps (1) blocking (2) sandwich hybridization of the target miRNAs and biotinylated probe DNAs and (3) signal
amplification by LFDA MiR-16 miR-21-5p and miR-500a-3p were used as target miRNAs since they are known as
cancer biomarkers [5-7] Fluorescence signals were captured by CCD camera and analyzed by the software (ImageJ)
Bright lines appeared at the expected positions they appeared only on the areas with the respective probe DNA in which
the target miRNAs had been supplied These data prove that the LFDA successfully took place in a target
sequence-dependent manner Calibration curves were plotted from the fluorescence signals The data points of the
calibration curve were fitted with the four-parameter logistic function and limit-of-detections (LODs) were evaluated by
the 3σ criterion LODs of the miR-16 miR-21-5p and miR-500a-3p were 68 fM 15 pM and 150 fM respectively The
LODs are on the same order of magnitude as concentrations of miRNA in blood Multiplex detection was verified from
correspondence between the calibration curves of single and multiplex The required sample volume was 05 microL and
assay time was 20 min Because most of the existing methods take more than a few hours the rapidness small required
sample volume and portability of the device are ideal advantages for POC diagnosis
References
[1] PS Mitchell et al PNAS 105 (2008) 10513 [2] K Hosokawa et al Lab Chip 4 (2004) 181 [3] K Hosokawa et al Anal
Chem 79 (2007) 6000 [4] H Arata et al PLoS ONE 7 (2012) e48329 [5] MJ Lodes et al PLoS ONE 4 (2009) e6229
[6] Y Toiyama et al J Natl Cancer Inst 105 (2013) 849 [7] Y Yamamoto et al Biomarkers 14 (2009) 529
19
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-5 Dr Wen-Hsuan Chiang
Assistant Researcher
Department of Biomedical Engineering and Environmental Sciences
National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
TEL (886) 3-571-5131 ext 35576
Education 2009 PhD Department of Chemical Engineering National Chung Hsing University Taiwan Thesis Supervisor Professor Hsin-Cheng Chiu 2002 BS Department of Chemical Engineering Tatung University Taiwan Professional Experience 2013 ndashpresent Assistant Researcher Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University 2010 ndash2012 Postdoctoral Fellow Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
Areas of Research Expertise Biomaterials Smart Amphiphilic Copolymers Multifunctional Nanocarriers for Cancer Therapy and Imaging Nano Science and Interfacial Engineering
Selected Publication (2010~) Wen-Hsuan Chiang Wen-Chia Huang Ming-Yin Shen Che-Hsu Wang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Dual-Layered Nanogel-Coated Hollow LipidPolypeptide Conjugate Assemblies for Potential pH-Triggered Intracellular Drug Release PLOS ONE 2014 9 1-11 Wen-Hsuan Chiang Wen-Chia Huang Chien-Wen Chang Ming-Yin Shen Zong-Fu Shih Yi-Fong Huang Sung-Chyr Lin Hsin-Cheng Chiu Functionalized Polymersomes with Outlayered Polyelectrolyte Gels for Potential Tumor-Targeted Delivery of Multimodal Therapies and MR Imaging Journal of Controlled Release 2013 168 280-288 Wen-Hsuan Chiang Viet Thang Ho Hsin-Hung Chen Wen-Chia Huang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Superparamagnetic Hollow Hybrid Nanogels as a Potential Guidable Vehicle System of Stimuli-Mediated MR Imaging and Multiple Cancer Therapeutics Langmuir 2013 29 6434-6443 Wen-Hsuan Chiang Viet Thang Ho Wen-Chia Huang Yi-Fong Huang Chorng-Shyan Chern Hsin-Cheng Chiu Dual Stimuli-Responsive Polymeric Hollow Nanogels Designed as Carriers for Intracellular Triggered Drug Release Langmuir 2012 28 15056-15064 Yi-Fong HuangDagger Wen-Hsuan ChiangDagger Pei-Ling Tsai Chorng-Shyan Chern Hsin-Cheng Chiu Novel Hybrid Vesicles Co-Assembled from Cationic Lipid and PAAc-g-mPEG with pH-Triggered Transmembrane Channels for Controlled Drug Release Chemical Communications 2011 47 10978-10980
20
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-5 Sep 13 2014 (Sat) 1140-1210 at NTHU BMES R120 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and Imaging
Applications
Wen-Hsuan Chiang
Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
In order to promote therapeutic efficacy and minimize side effect equipping these nanocarriers with the
capability of controlling drug release in response to an appropriate stimulus is essentially required Acidic pH
as an internal stimulus is particular appealing because of the mildly acid pH encountered in tumor tissues and
the intracellular compartments such as endosomes and lysosomes Therefore the pH-responsive drug carriers
have been extensively developed for improving intracellular drug delivery To realize the pH-responsive drug
release we adopted a simple approach to design the lipidPEG-containing complex vesicles with pH-triggered
transmembrane channels as a chemotherapy drug doxorubicin (DOX) delivery carrier In this study the
complex vesicles were attained by spontaneous co-assembly of poly(acrylic acid)-g-poly(monomethoxy
ethylene glycol) (PAAc-g-mPEG) with a cationic lipid didodecyldimethylammonium bromide (DDAB) in
aqueous phase of pH 89 via electrostatic interactions Through the formation of unionized AAc-rich
transmembrance channels of complex vesicles in weak acidic environments the acid-triggered rapid drug
release can be achieved
On the other hand for simultaneously monitoring disease progression and biological response after
treatments we developed a novel tumor-targeting polymersome system capable of delivering magnetic
resonance imaging (MRI) and chemotherapy The DOX-loaded magnetic polymersomes were first attained by
the self-assembly of lipid-containing copolymer poly(AAc-co-distearin acrylate) in aqueous solution
containing citric acid-coated superparamagnetic iron oxide nanoparticles (SPIONs) and followed by DOX
loading via electrostatic attraction To further functionalize these vesicles with superior in vivo colloidal
stability pH-tunable drug release and active tumor-targeting chitosan and poly( -glutamic
acid-co- -glutamyl oxysuccinimide)-g-PEG-folate (FA) were deposited in sequence onto the assembly outer
surfaces The interfacial nanogel layers via electrostatic interactions and in-situ covalent cross-linking were
thus produced Triggerable release of the encapsulated DOX was governed by dual external stimuli pH and
temperature When these theranostic NCPs were effectively internalized by HeLa cells via FA
receptor-mediated endocytosis and then exposed to high frequency magnetic fields (HFMF) the combined
effects of both pH and magnetic hyperthermia-triggered drug release and thermo-therapy resulted in greater
cytotoxicity than the treatment by DOX alone By virtue of the SPION clustering effect in the assembly inner
aqueous compartments the SPIONDOX-loaded NCPs displayed an r2 relaxivity value higher than Resovist
a commercial SPION-based T2 contrast agent The high magnetic relaxivity of the tumor-targeting NCPs
coupled with their enhanced cellular uptake considerably promoted the MRI contrast of targeted cancer cells
These results demonstrate the great potential of the FA-decorated SPIONDOX-loaded NCPs as an advanced
cancer theranostic nanodevice
21
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-1 Prof Hao-Li Liu Professor and Director
Department of Electrical Engineering
Chang Gung University
Phone +886-3-2118800 ext 5677
Fax +886-3-2118026
E-mail haoliliumailcguedutw
Education 2003 PhD National Taiwan University Taipei TAIWAN 1998 M S National Taiwan University Taipei TAIWAN 1996 B S National Taipei University of Technology TAIWAN
Professional Experience 2012-present Director Dept of Electrical Engineering Chang Gung Univ Taiwan 2011-present Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2008 Associate Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2005 ndash2008 Assistant Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2004 ndash2005 Research Fellow Department of Radiology Brigham amp Womenrsquos Hospital Harvard Medical School MA USA
Honor and awards (2009~) 2013 Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) 2013 The 2013 Frederick Lizzi Award International Society of Therapeutic Ultrasound 2011 Distinguished Tech-Coop Award (長庚大學優良教師技合獎) Chang-Gung University 2011 Wu Ta-You Memorial Award (吳大猷先生紀念獎) National Science Council Taiwan 2011 2010 Distinguished Research Award (長庚大學優良教師研究獎) Chang-Gung University
Selected Publication (2010~) HW Yang MY Hua TL Hwang KJ Lin CY Huang RY Tsai CCM Ma PH Hsu SP Wey PW Hsu PY Chen YC Huang YJ Lu TC Yen LY Feng CW Lin HL Liu KC Wei Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide Advanced Materials Vol 25 No 26 pp3605-3611 2013 HL Liu CH Fan CY Ting and CK Yeh Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors Theranostics Vol 4 No 4 pp432-444 2014 KC Wei PC Chu HYJ Wang CY Huang PY Chen HC Tsai YJ Lu IC Tseng PY Lee TC Yen and HL Liu Focused Ultrasound-induced BloodndashBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment A Preclinical Study PLoS ONE Vol 8 No 3 pp e58995 2013 P-H Hsu K-C Wei C-Y Huang C-J Wen T-C Yen C-L Liu Y-T Lin J-C Chen C-R Shen and H-L Liu Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound PLoS ONE Vol 8 No 2 pp e57682 2013 H-L Liu M-Y Hua H-W Yang C-Y Huang P-C Chu J-S Wua I-C Tseng J-J Wang T-C Yen P-Y Chen and K-C Wei ldquoMagnetic resonance monitoring of focused ultrasoundmagnetic nanoparticle targeting delivery of therapeutic agents to the brainrdquo Proceedings of National Academy of Science USA Vol 107 No 34 pp15205-15210 2010 H-L Liu M-Y Hua P-Y Chen P-C Chu C-H Pan H-W Yang C-Y Huang J-J Wang T-C Yen and K-C Wei ldquoBloodndashBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatmentrdquo Radiology Vol 255 No 2 pp 415-425 2010 H-L Liu Y-Y Wai P-H Hsu L-A Lyu J-S Wu C-R Shen J-C Chen T-C Yen and J-J Wang ldquoIn Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Bloodndashbrain Barrier with Focused Ultrasound A Magnetic Resonance Imaging Studyrdquo Journal of Cerebral Blood Flow amp Metabolism Vol 30 pp 168-177 2010
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
19
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker A-5 Dr Wen-Hsuan Chiang
Assistant Researcher
Department of Biomedical Engineering and Environmental Sciences
National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu Taiwan 30013 ROC
TEL (886) 3-571-5131 ext 35576
Education 2009 PhD Department of Chemical Engineering National Chung Hsing University Taiwan Thesis Supervisor Professor Hsin-Cheng Chiu 2002 BS Department of Chemical Engineering Tatung University Taiwan Professional Experience 2013 ndashpresent Assistant Researcher Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University 2010 ndash2012 Postdoctoral Fellow Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
Areas of Research Expertise Biomaterials Smart Amphiphilic Copolymers Multifunctional Nanocarriers for Cancer Therapy and Imaging Nano Science and Interfacial Engineering
Selected Publication (2010~) Wen-Hsuan Chiang Wen-Chia Huang Ming-Yin Shen Che-Hsu Wang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Dual-Layered Nanogel-Coated Hollow LipidPolypeptide Conjugate Assemblies for Potential pH-Triggered Intracellular Drug Release PLOS ONE 2014 9 1-11 Wen-Hsuan Chiang Wen-Chia Huang Chien-Wen Chang Ming-Yin Shen Zong-Fu Shih Yi-Fong Huang Sung-Chyr Lin Hsin-Cheng Chiu Functionalized Polymersomes with Outlayered Polyelectrolyte Gels for Potential Tumor-Targeted Delivery of Multimodal Therapies and MR Imaging Journal of Controlled Release 2013 168 280-288 Wen-Hsuan Chiang Viet Thang Ho Hsin-Hung Chen Wen-Chia Huang Yi-Fong Huang Sung-Chyr Lin Chorng-Shyan Chern Hsin-Cheng Chiu Superparamagnetic Hollow Hybrid Nanogels as a Potential Guidable Vehicle System of Stimuli-Mediated MR Imaging and Multiple Cancer Therapeutics Langmuir 2013 29 6434-6443 Wen-Hsuan Chiang Viet Thang Ho Wen-Chia Huang Yi-Fong Huang Chorng-Shyan Chern Hsin-Cheng Chiu Dual Stimuli-Responsive Polymeric Hollow Nanogels Designed as Carriers for Intracellular Triggered Drug Release Langmuir 2012 28 15056-15064 Yi-Fong HuangDagger Wen-Hsuan ChiangDagger Pei-Ling Tsai Chorng-Shyan Chern Hsin-Cheng Chiu Novel Hybrid Vesicles Co-Assembled from Cationic Lipid and PAAc-g-mPEG with pH-Triggered Transmembrane Channels for Controlled Drug Release Chemical Communications 2011 47 10978-10980
20
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-5 Sep 13 2014 (Sat) 1140-1210 at NTHU BMES R120 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and Imaging
Applications
Wen-Hsuan Chiang
Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
In order to promote therapeutic efficacy and minimize side effect equipping these nanocarriers with the
capability of controlling drug release in response to an appropriate stimulus is essentially required Acidic pH
as an internal stimulus is particular appealing because of the mildly acid pH encountered in tumor tissues and
the intracellular compartments such as endosomes and lysosomes Therefore the pH-responsive drug carriers
have been extensively developed for improving intracellular drug delivery To realize the pH-responsive drug
release we adopted a simple approach to design the lipidPEG-containing complex vesicles with pH-triggered
transmembrane channels as a chemotherapy drug doxorubicin (DOX) delivery carrier In this study the
complex vesicles were attained by spontaneous co-assembly of poly(acrylic acid)-g-poly(monomethoxy
ethylene glycol) (PAAc-g-mPEG) with a cationic lipid didodecyldimethylammonium bromide (DDAB) in
aqueous phase of pH 89 via electrostatic interactions Through the formation of unionized AAc-rich
transmembrance channels of complex vesicles in weak acidic environments the acid-triggered rapid drug
release can be achieved
On the other hand for simultaneously monitoring disease progression and biological response after
treatments we developed a novel tumor-targeting polymersome system capable of delivering magnetic
resonance imaging (MRI) and chemotherapy The DOX-loaded magnetic polymersomes were first attained by
the self-assembly of lipid-containing copolymer poly(AAc-co-distearin acrylate) in aqueous solution
containing citric acid-coated superparamagnetic iron oxide nanoparticles (SPIONs) and followed by DOX
loading via electrostatic attraction To further functionalize these vesicles with superior in vivo colloidal
stability pH-tunable drug release and active tumor-targeting chitosan and poly( -glutamic
acid-co- -glutamyl oxysuccinimide)-g-PEG-folate (FA) were deposited in sequence onto the assembly outer
surfaces The interfacial nanogel layers via electrostatic interactions and in-situ covalent cross-linking were
thus produced Triggerable release of the encapsulated DOX was governed by dual external stimuli pH and
temperature When these theranostic NCPs were effectively internalized by HeLa cells via FA
receptor-mediated endocytosis and then exposed to high frequency magnetic fields (HFMF) the combined
effects of both pH and magnetic hyperthermia-triggered drug release and thermo-therapy resulted in greater
cytotoxicity than the treatment by DOX alone By virtue of the SPION clustering effect in the assembly inner
aqueous compartments the SPIONDOX-loaded NCPs displayed an r2 relaxivity value higher than Resovist
a commercial SPION-based T2 contrast agent The high magnetic relaxivity of the tumor-targeting NCPs
coupled with their enhanced cellular uptake considerably promoted the MRI contrast of targeted cancer cells
These results demonstrate the great potential of the FA-decorated SPIONDOX-loaded NCPs as an advanced
cancer theranostic nanodevice
21
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-1 Prof Hao-Li Liu Professor and Director
Department of Electrical Engineering
Chang Gung University
Phone +886-3-2118800 ext 5677
Fax +886-3-2118026
E-mail haoliliumailcguedutw
Education 2003 PhD National Taiwan University Taipei TAIWAN 1998 M S National Taiwan University Taipei TAIWAN 1996 B S National Taipei University of Technology TAIWAN
Professional Experience 2012-present Director Dept of Electrical Engineering Chang Gung Univ Taiwan 2011-present Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2008 Associate Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2005 ndash2008 Assistant Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2004 ndash2005 Research Fellow Department of Radiology Brigham amp Womenrsquos Hospital Harvard Medical School MA USA
Honor and awards (2009~) 2013 Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) 2013 The 2013 Frederick Lizzi Award International Society of Therapeutic Ultrasound 2011 Distinguished Tech-Coop Award (長庚大學優良教師技合獎) Chang-Gung University 2011 Wu Ta-You Memorial Award (吳大猷先生紀念獎) National Science Council Taiwan 2011 2010 Distinguished Research Award (長庚大學優良教師研究獎) Chang-Gung University
Selected Publication (2010~) HW Yang MY Hua TL Hwang KJ Lin CY Huang RY Tsai CCM Ma PH Hsu SP Wey PW Hsu PY Chen YC Huang YJ Lu TC Yen LY Feng CW Lin HL Liu KC Wei Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide Advanced Materials Vol 25 No 26 pp3605-3611 2013 HL Liu CH Fan CY Ting and CK Yeh Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors Theranostics Vol 4 No 4 pp432-444 2014 KC Wei PC Chu HYJ Wang CY Huang PY Chen HC Tsai YJ Lu IC Tseng PY Lee TC Yen and HL Liu Focused Ultrasound-induced BloodndashBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment A Preclinical Study PLoS ONE Vol 8 No 3 pp e58995 2013 P-H Hsu K-C Wei C-Y Huang C-J Wen T-C Yen C-L Liu Y-T Lin J-C Chen C-R Shen and H-L Liu Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound PLoS ONE Vol 8 No 2 pp e57682 2013 H-L Liu M-Y Hua H-W Yang C-Y Huang P-C Chu J-S Wua I-C Tseng J-J Wang T-C Yen P-Y Chen and K-C Wei ldquoMagnetic resonance monitoring of focused ultrasoundmagnetic nanoparticle targeting delivery of therapeutic agents to the brainrdquo Proceedings of National Academy of Science USA Vol 107 No 34 pp15205-15210 2010 H-L Liu M-Y Hua P-Y Chen P-C Chu C-H Pan H-W Yang C-Y Huang J-J Wang T-C Yen and K-C Wei ldquoBloodndashBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatmentrdquo Radiology Vol 255 No 2 pp 415-425 2010 H-L Liu Y-Y Wai P-H Hsu L-A Lyu J-S Wu C-R Shen J-C Chen T-C Yen and J-J Wang ldquoIn Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Bloodndashbrain Barrier with Focused Ultrasound A Magnetic Resonance Imaging Studyrdquo Journal of Cerebral Blood Flow amp Metabolism Vol 30 pp 168-177 2010
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
20
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech A-5 Sep 13 2014 (Sat) 1140-1210 at NTHU BMES R120 Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery and Imaging
Applications
Wen-Hsuan Chiang
Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
In order to promote therapeutic efficacy and minimize side effect equipping these nanocarriers with the
capability of controlling drug release in response to an appropriate stimulus is essentially required Acidic pH
as an internal stimulus is particular appealing because of the mildly acid pH encountered in tumor tissues and
the intracellular compartments such as endosomes and lysosomes Therefore the pH-responsive drug carriers
have been extensively developed for improving intracellular drug delivery To realize the pH-responsive drug
release we adopted a simple approach to design the lipidPEG-containing complex vesicles with pH-triggered
transmembrane channels as a chemotherapy drug doxorubicin (DOX) delivery carrier In this study the
complex vesicles were attained by spontaneous co-assembly of poly(acrylic acid)-g-poly(monomethoxy
ethylene glycol) (PAAc-g-mPEG) with a cationic lipid didodecyldimethylammonium bromide (DDAB) in
aqueous phase of pH 89 via electrostatic interactions Through the formation of unionized AAc-rich
transmembrance channels of complex vesicles in weak acidic environments the acid-triggered rapid drug
release can be achieved
On the other hand for simultaneously monitoring disease progression and biological response after
treatments we developed a novel tumor-targeting polymersome system capable of delivering magnetic
resonance imaging (MRI) and chemotherapy The DOX-loaded magnetic polymersomes were first attained by
the self-assembly of lipid-containing copolymer poly(AAc-co-distearin acrylate) in aqueous solution
containing citric acid-coated superparamagnetic iron oxide nanoparticles (SPIONs) and followed by DOX
loading via electrostatic attraction To further functionalize these vesicles with superior in vivo colloidal
stability pH-tunable drug release and active tumor-targeting chitosan and poly( -glutamic
acid-co- -glutamyl oxysuccinimide)-g-PEG-folate (FA) were deposited in sequence onto the assembly outer
surfaces The interfacial nanogel layers via electrostatic interactions and in-situ covalent cross-linking were
thus produced Triggerable release of the encapsulated DOX was governed by dual external stimuli pH and
temperature When these theranostic NCPs were effectively internalized by HeLa cells via FA
receptor-mediated endocytosis and then exposed to high frequency magnetic fields (HFMF) the combined
effects of both pH and magnetic hyperthermia-triggered drug release and thermo-therapy resulted in greater
cytotoxicity than the treatment by DOX alone By virtue of the SPION clustering effect in the assembly inner
aqueous compartments the SPIONDOX-loaded NCPs displayed an r2 relaxivity value higher than Resovist
a commercial SPION-based T2 contrast agent The high magnetic relaxivity of the tumor-targeting NCPs
coupled with their enhanced cellular uptake considerably promoted the MRI contrast of targeted cancer cells
These results demonstrate the great potential of the FA-decorated SPIONDOX-loaded NCPs as an advanced
cancer theranostic nanodevice
21
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-1 Prof Hao-Li Liu Professor and Director
Department of Electrical Engineering
Chang Gung University
Phone +886-3-2118800 ext 5677
Fax +886-3-2118026
E-mail haoliliumailcguedutw
Education 2003 PhD National Taiwan University Taipei TAIWAN 1998 M S National Taiwan University Taipei TAIWAN 1996 B S National Taipei University of Technology TAIWAN
Professional Experience 2012-present Director Dept of Electrical Engineering Chang Gung Univ Taiwan 2011-present Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2008 Associate Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2005 ndash2008 Assistant Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2004 ndash2005 Research Fellow Department of Radiology Brigham amp Womenrsquos Hospital Harvard Medical School MA USA
Honor and awards (2009~) 2013 Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) 2013 The 2013 Frederick Lizzi Award International Society of Therapeutic Ultrasound 2011 Distinguished Tech-Coop Award (長庚大學優良教師技合獎) Chang-Gung University 2011 Wu Ta-You Memorial Award (吳大猷先生紀念獎) National Science Council Taiwan 2011 2010 Distinguished Research Award (長庚大學優良教師研究獎) Chang-Gung University
Selected Publication (2010~) HW Yang MY Hua TL Hwang KJ Lin CY Huang RY Tsai CCM Ma PH Hsu SP Wey PW Hsu PY Chen YC Huang YJ Lu TC Yen LY Feng CW Lin HL Liu KC Wei Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide Advanced Materials Vol 25 No 26 pp3605-3611 2013 HL Liu CH Fan CY Ting and CK Yeh Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors Theranostics Vol 4 No 4 pp432-444 2014 KC Wei PC Chu HYJ Wang CY Huang PY Chen HC Tsai YJ Lu IC Tseng PY Lee TC Yen and HL Liu Focused Ultrasound-induced BloodndashBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment A Preclinical Study PLoS ONE Vol 8 No 3 pp e58995 2013 P-H Hsu K-C Wei C-Y Huang C-J Wen T-C Yen C-L Liu Y-T Lin J-C Chen C-R Shen and H-L Liu Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound PLoS ONE Vol 8 No 2 pp e57682 2013 H-L Liu M-Y Hua H-W Yang C-Y Huang P-C Chu J-S Wua I-C Tseng J-J Wang T-C Yen P-Y Chen and K-C Wei ldquoMagnetic resonance monitoring of focused ultrasoundmagnetic nanoparticle targeting delivery of therapeutic agents to the brainrdquo Proceedings of National Academy of Science USA Vol 107 No 34 pp15205-15210 2010 H-L Liu M-Y Hua P-Y Chen P-C Chu C-H Pan H-W Yang C-Y Huang J-J Wang T-C Yen and K-C Wei ldquoBloodndashBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatmentrdquo Radiology Vol 255 No 2 pp 415-425 2010 H-L Liu Y-Y Wai P-H Hsu L-A Lyu J-S Wu C-R Shen J-C Chen T-C Yen and J-J Wang ldquoIn Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Bloodndashbrain Barrier with Focused Ultrasound A Magnetic Resonance Imaging Studyrdquo Journal of Cerebral Blood Flow amp Metabolism Vol 30 pp 168-177 2010
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
21
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-1 Prof Hao-Li Liu Professor and Director
Department of Electrical Engineering
Chang Gung University
Phone +886-3-2118800 ext 5677
Fax +886-3-2118026
E-mail haoliliumailcguedutw
Education 2003 PhD National Taiwan University Taipei TAIWAN 1998 M S National Taiwan University Taipei TAIWAN 1996 B S National Taipei University of Technology TAIWAN
Professional Experience 2012-present Director Dept of Electrical Engineering Chang Gung Univ Taiwan 2011-present Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2008 Associate Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2005 ndash2008 Assistant Professor Dept of Electrical Engineering Chang Gung Univ Taiwan 2004 ndash2005 Research Fellow Department of Radiology Brigham amp Womenrsquos Hospital Harvard Medical School MA USA
Honor and awards (2009~) 2013 Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) 2013 The 2013 Frederick Lizzi Award International Society of Therapeutic Ultrasound 2011 Distinguished Tech-Coop Award (長庚大學優良教師技合獎) Chang-Gung University 2011 Wu Ta-You Memorial Award (吳大猷先生紀念獎) National Science Council Taiwan 2011 2010 Distinguished Research Award (長庚大學優良教師研究獎) Chang-Gung University
Selected Publication (2010~) HW Yang MY Hua TL Hwang KJ Lin CY Huang RY Tsai CCM Ma PH Hsu SP Wey PW Hsu PY Chen YC Huang YJ Lu TC Yen LY Feng CW Lin HL Liu KC Wei Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide Advanced Materials Vol 25 No 26 pp3605-3611 2013 HL Liu CH Fan CY Ting and CK Yeh Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors Theranostics Vol 4 No 4 pp432-444 2014 KC Wei PC Chu HYJ Wang CY Huang PY Chen HC Tsai YJ Lu IC Tseng PY Lee TC Yen and HL Liu Focused Ultrasound-induced BloodndashBrain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment A Preclinical Study PLoS ONE Vol 8 No 3 pp e58995 2013 P-H Hsu K-C Wei C-Y Huang C-J Wen T-C Yen C-L Liu Y-T Lin J-C Chen C-R Shen and H-L Liu Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound PLoS ONE Vol 8 No 2 pp e57682 2013 H-L Liu M-Y Hua H-W Yang C-Y Huang P-C Chu J-S Wua I-C Tseng J-J Wang T-C Yen P-Y Chen and K-C Wei ldquoMagnetic resonance monitoring of focused ultrasoundmagnetic nanoparticle targeting delivery of therapeutic agents to the brainrdquo Proceedings of National Academy of Science USA Vol 107 No 34 pp15205-15210 2010 H-L Liu M-Y Hua P-Y Chen P-C Chu C-H Pan H-W Yang C-Y Huang J-J Wang T-C Yen and K-C Wei ldquoBloodndashBrain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatmentrdquo Radiology Vol 255 No 2 pp 415-425 2010 H-L Liu Y-Y Wai P-H Hsu L-A Lyu J-S Wu C-R Shen J-C Chen T-C Yen and J-J Wang ldquoIn Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Bloodndashbrain Barrier with Focused Ultrasound A Magnetic Resonance Imaging Studyrdquo Journal of Cerebral Blood Flow amp Metabolism Vol 30 pp 168-177 2010
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
22
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-1 Sep 13 2014 (Sat) 1320-1400 at NTHU BMES R120
Focused-Ultrasound Brain-Drug Delivery Approach and Application
Hao-Li Liu
Department of Electrical Engineering Chang-Gung University Taoyuan Taiwan
Abstract Focused ultrasound (FUS) technology which appears half century ago has got more and
more attention on its clinical therapeutic potential in recent years But only within few years focused
ultrasound with the presence of microbubbles has been noticed to be capable of locally and
reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its
potential in the delivery of macromolecules (gt 400 Da) into CNS including those therapeutic agents
(gt 90 among all) for CNS therapy which may not naturally cross the barrier into brain and brings
bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative
diseases such as Alzheimers amp Parkinsons diseases Herein since real-time image guidance is
necessary detecting and monitoring local drug release is one key step and a critical role to the
success of FUS brain drug delivery to make this new technology to be clinically relevant Current
advanced nanotechnology brings opportunity to design novel nano-carriers to serve both as an image
indicator and therapeutic agents to allow simultaneous diagnostic imaging and drug delivery
monitoring in vivo in real time In this presentation we report the current progress on the in-vivo
animal testing as the proof-of-concept Novel nanoparticles (including diagnostic and therapeutic
nanoparticles) will be introduced about their participation of the procedure (including safety
biodistribution agent quantification and treatment evaluation) among different imaging platforms
(including MRI ultrasound nuclear imaging) and their efficacy will be discussed
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
23
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-2 Dr Ichio Aoki Team Leader
Multimodal Molecular Imaging Team
Molecular Imaging Center
National Institute of Radiological Sciences (NIRS) Japan
Anagawa 4-9-1 Inage Chiba-city 263-8555 Japan
Phone +81-43-206-3272 Fax +81-43-206-3276
aokinirsgojp
Education 1999 PhD Meiji University of Oriental Medicine (MUOM) for the thesis entitled Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat (Thesis supervisor Prof Chuzo Tanaka Department of Neurosurgery) 1965 MS MUOM (Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI) 1993 BS Faculty of Acupuncture Meiji University of Oriental Medicine Japan Professional Experience 2007 ndashpresent Team Leader Molecular Imaging Center NIRS Japan 2006 ndash2007 Senior Scientist Molecular Imaging Center NIRS Japan 2003 -2006 Assistant Professor Department of Medical Informatics MUOM Japan 2000 -2002 Visiting fellow Laboratory of functional and molecular imaging (LFMI) NINDSNIH USA
Honor and awards (2009~) Best Presentation Award 8th meeting of Japanese society for molecular imaging 2013 Research award of the National Institute of Radiological Sciences 2010 Executive Board Japanese Society for Magnetic Resonance in Medicine (2012 - present) Annual Meeting Program Committee (AMPC) International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
Selected Publication (2010~) Bennett KM Jo JI Cabral H Bakalova R Aoki I MR imaging techniques for nano-pathophysiology and theranostics Adv Drug Deliv Rev 2014 Apr 27 piiS0169-409X(14)00092-1 Mi P Kokuryo D Cabral H Kumagai M Nomoto T Aoki I et al Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors J Control Release 2014 Jan 2817463-71 Maruyama M et al Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 2013 Sep1879(6)1094-108 Saito S Hasegawa S Sekita A Bakalova R Furukawa T Murase K Saga T Aoki I Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo Cancer Res 2013 Jun 173(11)3216-24 Kaida S Cabral H Kumagai M Kishimura A Terada Y Sekino M Aoki I Nishiyama N Tani T Kataoka K Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res 2010 Sep 1570(18)7031-41
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
24
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-2 Sep 13 2014 (Sat) 1400-1440 at NTHU BMES R120 Responsive and Theranostic Nano-contrast Agents for Preclinical MR imaging
Ichio Aoki PhD
Molecular Imaging Center National Institute of Radiological Sciences Japan
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDSs) is opening new
pathways to understanding pathophysiology using MRI In the clinic paramagnetic metal chelates such as Gd-DTPA or
Gd-DOTA shorten tissue longitudinal relaxation time (T1) and are often used as lsquopositiversquo MRI contrast agents It has
also long been known that Mn2+ can be used as a positive intracellular MRI contrast agent for small animal
Manganese-enhanced MRI (MEMRI) provides a unique opportunity to study neuronal activation and architecture 1 The
underlying principle of MEMRI relies in the fact that Mn2+ behaves in a manner similar to Ca2+ in many biological
systems Extracellular Mn2+ can enter cells through NMDA receptors for glutamate 2 andor voltage-gated Ca2+
channels 3 Thus Mn2+ can behave as a functional contrast agent depending on the cellular activityviability In this
presentation I would like to summarize the recent progress of MEMRI and manganese-based contrast agents for
neuroimaging 4 and cancer research 5
Nanoparticles have for many years also been investigated as possible MRI contrast agents For example
carboxydextran-coated superparamagnetic iron oxide (SPIO) nanoparticles shorten the tissue transverse relaxation times
(T2 and T2) and have been clinically used as a negative contrast agent for hepatic tumor diagnosis A nano-DDS is
defined as the specific delivery of drugs to organs tissues or cells using nanoparticles Most nanoparticles are captured
by the reticuloendothelial system (RES) following intravenous injection and do not accumulate at the therapeutic or
diagnostic target in sufficient concentrations To avoid the capture and thereby prolong blood half-life polyethylene
glycol (PEG) polymer chains are often covalently attached to the surface of the nanoparticle The PEGylated nanoparticle
has an increased probability for accumulation in the target Another important requirement for effective tumor targeting is
that the diameter of the PEGylated nanoparticles must be 10-150 nm Only nanoparticles with these dimension can
ldquopassivelyrdquo accumulate in the targeted area through the enhanced permeability and retention (EPR) effect that heightens
tumor vasculature permeability and prolongs tumor tissue retention 6 In another approach known as ldquoactive targetingrdquo
nanoparticles with antibody peptide or protein coatings have been shown to facilitate binding to the surface of tumor or
neovascular endothelial cells despite having a lower blood half-life
Nano-carriers for DDSs can contain multiple functional elements such as therapeutic drugs MRI contrast agents
fluorescent or luminescent dyes and radioisotopes without serious changes to the particle kineticsdynamics The
development of such multifunctional nano-DDSs and imaging has accordingly become a subject of widespread research
Various materials have also been reported as nano-DDS carriers including micelles liposomes emulsions dendrimers
quantum dots (QDs) and carbon materials such as fullerenes with each material providing a different set of
characteristics as a nano-DDS carrier I will also summarize our recent research into nano-DDS-based contrast agents for
cancer 7 [1] a) Y J Lin and A P Koretsky Magn Reson Med 1997 38 378‐388 b) I Aoki et al Neuroimage 2004 22 1046‐1059 c) J H Lee et al Magn Reson Med 2005 53 640‐648 [2] K Itoh et al Neuroscience 2008 154 732‐740 [3] H Kita et al Brain Res 1981 205 111‐121 [4] a) Y Kawai et al Neuroimage 2010 49 3122‐3131 b) C Leuze et al Neuroimage 2011 [5] S Saito et al Cancer Res 2013 73 3216‐3224 [6] H Maeda and Y Matsumura Crit Rev Ther Drug Carrier Syst 1989 6 193‐210 [7] a) S Kaida et al Cancer Res 2010 70 7031‐7041 b) K Kono et al Biomaterials 2011 32 1387‐1395 c) D Kokuryo et al J Control Release 2013 Bennett KM et al Adv Drug Deliv Rev 2014
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
25
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-3 Prof Tomoko Masaike Junior Associate Professor Department of Applied Biological Science Tokyo University of Science
Address Department of Applied Biological Science Tokyo University of Science
3rd Floor 6th Building 2641 Yamazaki Noda City Chiba Prefecture 278-8510
Japan
TEL +81-(47) -124-1501 ext 3401
Education 2002 PhD Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1999 MSc Department of Electronic Chemitsry Tokyo Institute of Technology Japan 1998 MPhil Department of Chemistry University of Cambridge England 1996 BAin Science Department of Chemistry and Department of Information Science
International Christian University Japan
Professional Experience 2013ndash Present Junior Associate Professor Department of Applied Biological Science
Tokyo University of Science 2005ndash2013 Research Associate and Assistant Professor Department of Physics Gakushuin
University 2002ndash2005 Postdoctoral Fellow ERATO Yoshida ATP system Project
Japan Science and Technology Agency 1999ndash2002 Research Fellow of the Japan Society for the Promotion of Science
Honor and awards (2008~) The 5th Shiseido Female Researcher Science Grant (2012) Committee member of the Biophysical Society of Japan (2011-2015) The 4th Early Research in Biophysics Award Biophysical Society of Japan (2008)
Selected Publication (2002~) Cooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80˚ and 40˚ substep rotations Masaike T Horibe-Koyama F Oiwa K Yoshida M Nishizaka T Nature Structural and Molecular Biology 15 1326-33 (2008) Probing conformations of the subunit of FoF1 -ATP synthase in catalysis Masaike T Suzuki T Tsunoda S P Konnno H Yoshida M Biochemical and Biophysical Research Communications 342 800-807 (2006) The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Yasuda R Masaike T Adachi K Noji H Itoh H and Kinosita K Jr Proceedings of the National Academy of Sciences USA 100 9314-9318 (2003) F1-ATPase changes its conformations upon phosphate release Masaike T Muneyuki E Noji H Kinosita K Jr Yoshida M Journal of Biological Chemistry 277 21643-21649 (2002)
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
26
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-3 Sep 13 2014 (Sat) 1440-1510 at NTHU BMES R120
Observation of Single-Molecule Enzymes through Probes under the Optical Microscope
Tomoko Masaike
Department of Applied Biological Science Tokyo University of Science
Almost all the chemical reactions in living organisms are catalyzed by enzymes Therefore
elucidation of the mechanisms of enzymes is the key to understanding of life The aim of our
research is to correlate local motions and chemistry occurring in single molecules of enzymes in
order to explain how biological functions are achieved
One of our target enzymes is an ATP-hydrolyzing protein F1-ATPase whose central shaft is
known to rotate against a surrounding cylinder containing catalytic sites of the ATPase reaction It is
a soluble part of FoF1-ATP synthase an enzyme which catalyzes synthesis of energy currency of the
cell ATP Since single-molecule rotation assay was established in 1997 researchersrsquo focus had been
on the relationship between chemical reaction steps of ATP hydrolysis and rotational steps of the
central shaft subunit Nevertheless at that time we had no means to investigate another important
aspect of the mechanism coordinated local conformational changes of the catalytic cylinder subunits
that lead to rotation of the shaft
The new microscopy named ldquoTotal Internal Reflection Fluorescence Microscopy (TIRFM)
with periodic polarization modulationrdquo was applied to detect motions in the cylinder subunits
through changes in orientation of dipoles in fluorescent single molecules Meanwhile rotation of the
shaft was also monitored through polystyrene beads As a result three-step domain motions of the
terminal region of the catalytic cylinder subunits were correlated with rotational substeps of the shaft
and moreover with chemical reaction steps (Masaike T et al Nature Structural and Molecular
Biology 2008)
We recently extend this project to domain mapping of gradual conformational changes in the
cylinder Mapping local conformational changes of multiple regions will clarify how subtle
conformational changes at the catalytic sites are coordinated and propagated to distant domains We
are convinced that this experimental system will be widely applied to enzymes including membrane
proteins Mechanisms of various enzymes will be revealed by direct observation of local
conformational changes in single molecules under the optical microscope Our future direction is to
apply these techniques to in vivo imaging as well
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
27
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-4 Prof Meng-Lin Li Associate Professor
Department of Electrical Engineering National Tsing Hua University
Address Delta building R827 Department of Electrical Engineering
National Tsing Hua University 101 Sec 2 Kuang Fu Rd Hsinchu Citiy
30013 Taiwan
TEL +886-3-5162179
FAX +886-3-5715971
Education 2004 PhD Department of Electrical Engineering National Taiwan University Taiwan 1999 BS Department of Electrical Engineering National Taiwan University Taiwan Professional Experience 2011ndashpresent Associate Professor Department of Electrical Engineering National Tsing Hua
University 2006ndash2011 Assistant Professor Department of Electrical Engineering National Tsing Hua
University 200 -2006 Postdoctoral Research Associate Optical Imaging Lab Department of Biomedical
Engineering Texas AampM University
Honor and awards (2009~) Seno Medical Best Paper Award Photons Plus Ultrasound Imaging and Sensing 2014 (Part of SPIE Photonics West 2014) Outstanding Young Electrical Engineer Award Chinese Institute of Electrical Engineering (2013) Dr Wu Da-You Memorial Award National Science Council Taiwan (2012) Young Faculty Research Award National Tsing Hua University (2011)
Selected Publication (2010~) T-C Hsiao Y-Y Cheng W-T Tein S-B Luo D-Y Chiou R-J Chung and Meng-Lin Li ldquoDeep-penetration photoacoustic array imaging of calcificationsrdquo J Biomed Opt 18 066002-1 (2013) H-W Yang H-L Liu Meng-Lin Li I-W Hsi C-T Fan C-Y Huang Y-J Lu M-Y Hua H-Y Chou J-W Liaw C-C M Ma K-C Wei ldquoMagnetic gold-nanorodPNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapyrdquo Biomaterials 34 5651 (2013) ( equal contribution) L-D Liao C-T Lin Y-Y I Shih T Q Duong H-Y Lai P-H Wang R Wu S Tsang J-Y Chang Meng-Lin Li and Y-Y Chen ldquoTranscranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopyrdquo J Cerebr Blood F Met 32 938 (2012) ( co-corresponding author feature article highlighted with a commentary) L-D Liao Meng-Lin Li H-Y Lai Y-Y I Shih Y-C Lo S Tsang P C-P Chao C-T Lin F-S Jaw and Y-Y Chen ldquoImaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopyrdquo NeuroImage 52 562 (2010)
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
28
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-4 Sep 13 2014 (Sat) 1630-1710 at NTHU BMES R120
Dynamic Pulsed Magnetomotive Ultrasound Imaging ndash Visualizing SPIO Nanoparticles Ultrasonically
Meng-Lin Li
Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan
Recently pulsed magnetomotive ultrasound (pMMUS) imaging has been introduced to detect
superparamagnetic iron oxide nanoparticles (SPIO) which is not able to be visualized by
conventional ultrasound However because of the used magnetic short pulse the reported pMMUS
only can use a single-element ultrasound transducer along with mechanical scanning to perform
imaging which significantly limits the imaging fame rates
To solve this problem we propose a plane wave based dynamic pMMUS imaging technique
The ultrafast plane wave imaging frame rate is fast enough to track the magneto-motion of the
excited SPIOs ultrasonically during the period of the magnetic pulse being applied That is the
proposed dynamic pMMUS imaging technique is capable of visualizing the dynamic response of the
excited SPIOs which is highly correlated to tissue viscoelasticity to an externally-applied magnetic
pulse In addition a new pMMUS imaging algorithm based on the imaged dynamic response of
SPIOs is developed to provide multi-parametric visualization under magnetic field inhomogeneity
In our experiments a 5 kHz ultrafast imaging frame rate was used to implement the dynamic
pMMUS where the SPIO motion induced by an 8-ms magnetic pulse was tracked The results
showed that there were significant differences between the dynamic pMMUS images of the
phantoms with and without SPIOs embedded In addition agarose phantoms with 05 1 and
15 agarose were used to mimic tissues with different elasticity The dynamic responses of the
excited SPIOs in the three types of phantoms were distinguishable
Overall it is demonstrated that the feasibility of our proposed dynamic pMMUS imaging
technique for the visualization of the magneto-motion and dynamic response of the SPIOs under the
excitation of a short magnetic pulse Future work will focus on the improvement of the
magneto-motion tracking algorithm relationship between the dynamic response of the excited SPIOs
and the tissue viscoelasticity and exploration of medical applications of the proposed dynamic
pMMUS imaging technique
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
29
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-5 Chih-Chung Huang PhD Assistant Professor
Department of Biomedical Engineering
National Cheng Kung University
Address No 1 University Rd Tainan 70101 Taiwan
TEL + 886-6-2757575 ext63428
FAX +886-6-234-3270
Education 2003~2007 PhD Biomedical Engineering Chung Yuan Christian University Taiwan 2002~2003 MS Biomedical Engineering Chung Yuan Christian University Taiwan 1998~2002 BS Biomedical Engineering Chung Yuan Christian University Taiwan
Professional Experience 2013~present Assistant Professor Department of Biomedical Engineering National Cheng Kung University Taiwan 2012~2013 Associate Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2008-2012 Assistant Professor Department of Electrical Engineering Fu Jen Catholic University Taiwan 2006-2007 Research Fellow Biomedical Engineering University of Southern California USA 2005-2006 Lecturer Biomedical Engineering Yuan Pei University Taiwan
Honor and awards (2009~) 2014 Best Potentiality Award Biomedical Engineering Innovation Competition Taiwan 2013 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2013 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Poster Paper Competition Taiwan 2012 JMBE Annual Excellent Paper Award Taiwan 2012 Certificate High Distinction Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 Honorable Mention Award Symposium of Annual Conference of the Biomedical Engineering Society Oral Paper Competition Taiwan 2012 The Best Advisor Award Creative Design and Implementation Competition on Biomedical Engineering Taiwan
Selected Publication (2010~) Chih-Chung Huang and Wei-Tsen Chen ldquoDeveloping High-Frequency Ultrasound Tomography for Testicular Tumor Imaging in Rats an In Vitro Studyrdquo Medical Physics Vol 41 No 1 pp012902-1-9 2014 Ting-Yu Liu Po-Yang Lee Chih-Chung Huang Lei Sun and K Kirk Shung ldquoThe ventricular function of adult zebrafish investigated by retrospective Doppler-gated ultra-high-frame-rate echocardiographyrdquo IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control Vol 60 No 9 pp1827-1837 2013 Cho-Chiang Shih Chih-Chung Huang Qifa Zhou and K Kirk Shung ldquoHigh resolution acoustic radiation force impulse imaging for assessing corneal sclerosisrdquo IEEE Transactions on Medical Imaging Vol 32 No 7 pp1316-1324 2013 Chih-Chung Huang Pay-Yu Chen and Cho-Chiang Shih ldquoEstimating the Viscoelastic Modulus of a Thrombus using an Ultrasonic Shear-Wave Approachrdquo Medical Physics Vol 40 pp042901-7 2013
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
30
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-5 Sep 13 2014 (Sat) 1710-1740 at NTHU BMES R120
High resolution ultrasound elastography for medical applications
Chih-Chung Huang
Department of Biomedical Engineering National Cheng Kung University
It is well known that the mechanical properties of soft tissues such as elasticity viscosity and
mechanical impedance change depending on the conditions of tissues for instance disease and age
hence there mechanical properties may give useful information in medical diagnosis Several direct
force applied methods have been proposed to measure the mechanical properties of tissue
quantitatively such as sonoelastographic image Besides uses of acoustic radiation force to remotely
palpate tissue have been developed by various researchers as an alternative to conventional
ultrasound elasticity image However most operational frequencies of acoustic radiation force
imaging are smaller than 10 MHz The resolution of 10 MHz is not good enough for imaging the
microstructure in some eye tissue Consequently we attempt to develop the high frequency acoustic
radiation force technology for providing high resolution elasticity image in ophthalmology
applications The main purpose of this project is to develop the high frequency acoustic radiation
force technology for characterizing the mechanical properties of soft tissue such as thrombosis and
cornea In thrombosis study the theoretical analysis and experimental verification of using acoustic
radiation force to measure the viscoelastic properties of clot were proposed The blood clots were
created artificially with different coagulating factors such as hematocrit fibrinogen and thrombin
Both of viscous and elastic parameters of blood clot were measured for the further development of
acoustic radiation force technology in thrombosis applications In cornea study a 20-50 MHz high
frequency acoustic radiation force impulse (ARFI) image system were built for mapping the
hardness of cornea A two elements confocal ultrasonic transducer was designed for this objective
The outer 10 MHz element was used to push the fibers in cornea and the inner 50 MHz element was
used to detect the displacement of cornea The experiments were carried out using artificial porcine
cornea and a new algorithm for high frequency ARFI imaging was established Furthermore the
feasibility of using high frequency ARFI image for identifying the mechanical properties of cornea
and retinal vein thrombosis were be performed We applied our high frequency ARFI image system
into intravascular ultrasound (IVUS) In the first stage a concept of combining the high frequency
AFRI and shear wave technology on IVUS for assessing the mechanical properties of thrombus and
vessel was proposed in present study
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
31
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker B-6 Prof Masao Kamimura Assistant Professor
Department of Materials Science and Technology
Faculty of Industrial Science and Technology Tokyo University of Science
Address 6-3-1 Niijuku Katsushika-ku Tokyo 125-8585 Japan
TEL +81-3-5876-1717 (ext 1819)
FAX +81-3-3609-3866
Education 2012 PhD Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2009 MS Graduate School of Pure and Applied Sciences University of Tsukuba Japan 2007 BS Department of Materials Science and Technology Tokyo University of Science Japan
Professional Experience 2014-present Assistant Professor Department of Materials Science and Technology Tokyo University of Science Japan 2013-2014 MANA Research associate World Premier International Research Center Initiative (WPI) International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Japan 2012-2013 Postdoctoral Research Associate Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2010 Visiting Scientist Center for Drug Delivery and Nanomedicine (CDDN) University of Nebraska Medical Center (UNMC) United States 2009-2012 Research fellow of the Japan Society for the Promotion of Science (JSPS DC1)
Honor and awards Departmental dean prize (Cum Laude) University of Tsukuba (2009) Carl Zeiss prize The 16th Japan Bioimaging Society (2007)
Selected Publications Masao Kamimura Yukio Nagasaki PEGylated polymer micelles for anti-cancer drug delivery carrier Colloid and Interface Science in Pharmaceutical Research and Development (in press) Masao Kamimura Tatsuhiko Furukawa Shin-ichi Akiyama Yukio Nagasaki Enhanced intracellular drug delivery of pH-sensitive doxorubicinpoly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells Biomaterials Science (2013) 1 361-367 (Selected as the back cover of the issue) (ldquoTop 10 Most-accessed articles in February and March 2013) Masao Kamimura Yukio Nagasaki pH-sensitive polymeric micelles for enhanced intracellular anti-cancer drug delivery Journal of Photopolymer Science and Technology (2013) 26 161-164 Masao Kamimura Jong Oh Kim Alexander V Kabanov Tatiana K Bronich Yukio Nagasaki Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly StablepH-Responsive Drug Delivery System Journal of Controlled Release (2012) 160 486-494 Masao Kamimura Naoki Kanayama Kimikazu Tokuzen Kohei Soga Yukio Nagasaki Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate) Nanoscale (2011) 3 3705-3713 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Preparation of PEG and protein co-immobilized upconversion nanophosphors as near-infrared biolabeling materials Journal of Photopolymer Science and Technology (2008) 21 2 183-187 Masao Kamimura Daisuke Miyamoto Yu Saito Kohei Soga Yukio Nagasaki Design of poly(ethylene glycol)streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling Langmuir (2008) 24 16 8864-8870
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
32
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech B-6 Sep 13 2014 (Sat) 1740-1810 at NTHU BMES R120
Biofunctional Polymers for Application of Ceramic Nanoparticles for Fluorescence Bioimaging
Masao Kamimura and Kohei Soga
Department of Materials Science and Technology Tokyo University of Science
The application of nanoparticles (NPs) for biomaterials is increasing rapidly and offers excellent
prospects for the development of novel technology for the diagnosis and therapy Recently we
worked on the creation of biofunctional polymer based NPs for fluorescence bioimaging agents In
order to apply NPs for biomaterials improvement of surface property of NPs is one of the most
important factors for successful diagnosis and therapy Therefore our research mainly focused on the
synthesis and characterization of biofunctional polymers for the NPs preparations Poly(ethylene
glycol) (PEG) is well known as biocompatible polymer to improve the biocompatibility and
dispersion stability of NPs under physiological conditions Additionally PEG chain on the NP
surface prevents nonspecific adsorption of proteins and other biomolecules
In this presentation we will present the PEG modified rare-earth doped ceramic nanophosphors
(RED-CNPs) for the fluorescence bioimaging probes Fluorescence bioimaging has become an
important method in the biological medical and pharmaceuticals sciences because of its high
sensitivity and resolution However this technique suffers from serious problem due to the
fluorescence bioimaging generally employs a short wavelength excitation source Short wavelength
light cannot penetrate deeply due to absorption and scattering The near-infrared (NIR) wavelength
region between 800 to 2000 nm is so-called lsquobiological windowrsquorsquo NIR light in this region
demonstrates a high penetration property into the biological tissues However the use of devices
based on semiconductor silicon has limited the wavelength of the fluorescence bioimaging to less
than 1000 nm Recently InGaAs CCD cameras have been developed for observation in the longer
wavelength region which allow for imaging of the over-1000-nm (OTN)-NIR light On the other
hand RED-CNPs are known to fluorescence efficiently in the OTN-NIR wavelength region under
NIR excitation Recently we have developed polymer modified RED-CNPs based fluorescence
probes for OTN-NIR fluorescence bioimaging This presentation will report recent progress of the
development of biofunctional polymer modified RED-CNPs for OTN-NIR fluorescence bioimaging
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
33
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-1 Prof Keishi Nishio Professor
Department of Material Science and Thechnology Tokyo University of
Science
Address 6-3-1 Niijyuku Katsushika-Ku Tokyo JAPAN 125-8585
TEL +81-3-5876-1421
FAX +81-3-5876-1421
Education 1994-1997 Department of Materials Science and Technology (doctor course) Tokyo University of Science PhD in Engineering 1992-1994 Department of Materials Science and Technology (graduate school) Tokyo University of Science 1988-1992 Department of Materials Science and Technology (under graduate school) Tokyo University of Science
Professional Experience 2013-present Professor (Department of Materials Science and Technology Tokyo University of Science) 2007-2013 Associate professor (Department of Materials Science and Technology Tokyo University of Science) 2003-2007 Lecturer (Department of Materials Science and Technology Tokyo University of Science) 1998-2003 Research associate (Department of Materials Science and Technology Tokyo University of Science) 1997-1998 Musashi Institute of Technology as Research Fellowship for Young Scientists of Japan Society for the Promotion of Science
Honor and awards The Society of Inorganic Materials Japan ldquoDr Nagai Memorial Incentive Awardrdquo (2007)
Selected Publication Hirobumi Shibata Taku Ogura Keishi Nishio Hideki Sakai Masahiko Abe Kazuaki Hashimoto Mutsuyoshi Matsumoto Facile synthesis of mesoporous gold particles using silica as a binder through a solvent evaporation process Trans Mat Res Soc Japan 38 2 221-223 (2013) Takanori Imai Yoshimoto Abe Keishi Nishio Ryuji Tamura Hirobumi Shibata Tohru Kineri and Takahiro Gunji Preparation of platinum nanoparticles that are dispersible in water over a wide pH range POLYMER JOURNAL 45 540-544 (2012) TATSUYA SAKAMOTO TSUTOMU IIDA YUTAKA TAGUCHI SHOTA KUROSAKI YUSUKE HAYATSU KEISHI NISHIO YASUO KOGO and YOSHIFUMI TAKANASHI Examination of a Thermally Viable Structure for an Unconventional Uni-Leg Mg2Si Thermoelectric Power Generator J ELECTRO MATER (2012) doi101007s11664-012-1974-0 Yuki Yamaguchi Yukari Emoto Tohru Kineri Masakatsu Fujimoto Hideo Mae Atsuo Yasumori and Keishi Nishio Hydrogen gas-sensing properties of PtWO3 thin films in various measurement conditions Ionics 18 (2012) 449-453 DOI101007s11581-012-0683-2 Y Yamaguchi T Kineri M Fujimoto H Mae A Yasumori and K Nishio Investigation of Electrical Hydrogen Detection Properties of PtWO3 Thin Films Prepared by Sol-Gel Method Key Engineering Materials 485 (2011) pp271-274
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
34
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-1 Sep 14 2014 (Sun) 0900-0930 at NTHU BMES R120
Gasochromic and Electrical Properties of Pt-Nanoparticle-Dispersed Tungsten Oxide Thin Films for Hydrogen Gas Sensor
Keishi Nishio
Department of Materials Science and Technology
It is well known that tungsten tri-oxide (WO3) exhibits electrochromic and gasochromic properties
When Pt-nanoparticle-dispersed tungsten oxide (PtWO3) is exposed to hydrogen gas the optical
and electrical properties of the PtWO3 change drastically Consequently it is expected that thin
films of WO3 can be applied as hydrogen gas leakage sensors We prepared PtWO3 thin films on
glass substrates by a sol-gel process The optical and electrical properties of the films were evaluated
A sol-gel process can be used to prepare ceramics and glasses at lower temperatures than
conventional sintering processes In general the sol-gel process uses metal alkoxides or metal salts
as starting precursors Some kinds of alcohol are used as organic solvents But metal alkoxides are
more expensive than metal salts These materials are very difficult to handle We prepared metal
oxide powders thin films with the solution consisted with metal salts (usually metal chloride) and
organic solvents because metal alkoxides can be obtained easily from metal chloride and alcohol
The coating solution used to obtain the thin films consisted of tungsten hexachloride and hydrogen
hexachloroplatinate (IV) hexahydrate as raw materials and ethanol as a solvent The films were
prepared on alkaline free glass substrates by a spin coating method after appropriate heat treatment
Amorphous and crystalline WO3 were easily obtained by changing the heat-treatment temperature
The ion diffusion coefficient of the film depended on the WO3 structure (ie whether it was
amorphous or crystalline) because the density of amorphous WO3 is lower than that of crystalline
WO3 Films with low crystallinity were found to have superior chromic properties to both those with
high crystallinity and amorphous films The results of FTIR analyses showed that W=O and W-O
bonds existed in the amorphous film and that the W=O bonds decreased as the heat treatment
temperature was increased forming a W-O-W bond The existence of the W=O bond in the WO3
structure is thought to reduce the chromic properties The PtWO3 thin film prepared at 673K
showed the largest change in optical transmittance and electrical conductivity when exposed to H2
gas compared with thin films prepared at other temperatures When this film was exposed to 100
H2 gas the normalized transmittance decreased rapidly (in less than 02 sec) from 100 to almost
50 The optical absorbance of the film was dependent on the H2 gas concentration (mixed with N2
gas) in the range from 01 to 5 and the relationship between them was linear The relationship
between the electrical conductivity and hydrogen gas concentration (mixed with N2 gas) in the range
from 100 to 10000ppm was also linear
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
35
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-2 Prof Hsing-Cheng Hsi Associate Professor
Graduate Institute of Environmental Engineering National Taiwan University
71 Chou-Shan Rd Taipei 106 Taiwan
TEL (886)2 33664374
FAX (886)2 23928830
Education 2001 PhD Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL USA 1994 MS Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 1963 BS Agricultural Chemistry (Soil amp Fertilizer Division) Department of Agricultural Chemistry National Taiwan University Taipei Taiwan
Professional Experience 2013 ndashpresent Associate Professor Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan 2009 ndash2013 Assistant and Associate Professor Institute of Environmental Engineering and Management National Taipei University of Technology Taipei Taiwan 2002 -2008 Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology Kaohsiung Taiwan 2002 Assistant Professor Department of Environmental Engineering and Management Chaoyang University of Technology Taichung Taiwan
Honor and awards (2009~) Outstanding Research Award Collage of Engineering National Taipei University of Technology (2012) Excellent Teaching Award Collage of Engineering National Taipei University of Technology (2012) Outstanding Teaching Award National Kaohsiung First University of Science and Technology (2009)
Selected Publication (2010~) Chen SS Hsi HC Nian SH Chiu CH Synthesis of N-doped TiO2 photocatalyst for low-concentration elemental mercury removal under various gas conditions Applied Catalysis B Environmental 2014 160ndash161 558ndash565 Chiu CH Hsi HC Lin CC Control of mercury emissions from coal-combustion flue gases using CuCl2-modified zeolite and evaluating the cobenefit effects on SO2 and NO removal Fuel Processing Technology 2014 126 138ndash144 Hsi HC Tsai CY Lin KJ The impact of surface functional groups water vapor and flue gas components on mercury adsorption and oxidation by sulfur-impregnated activated carbons Energy Fuel 2014 28(5) 3300ndash3309 Hsi HC Jiang CB Yang TH Chien LC The neurological effects of prenatal and postnatal mercurymethylmercury exposure on three-year-old children in Taiwan Chemosphere 2014 100 71-76 Hsi HC Rood M J Rostam-Abadi M Chang YM Effects of sulfur nitric acid and thermal treatments on the properties and mercury adsorption of activated carbons from bituminous coals Aerosol and Air Quality Research 2013 13(2) 730-738
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
36
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-2 Sep 14 2014 (Sun) 0930-1000 at NTHU BMES R120
Control of low-concentration gaseous mercury from stationary sources via adsorption and oxidation
Hsing-Cheng Hsi
Graduate Institute of Environmental Engineering National Taiwan University
Coal combustion has been targeted as one of the major anthropogenic sources of atmospheric
Hg occupying 30 of the total anthropogenic Hg emission Several countries have been proposing
more stringent regulations on the abatement of Hg emission Notably the Minamata Convention on
Mercury delivered in 19 March 2013 explains the necessity of Hg emissionrelease prevention and
abatement via global and legally-binding agreements between countries Gaseous Hg had high
volatility and low concentration in coal-combustion flue gases therefore it is difficult to remove by
conventional air pollution control devices (APCDs)
This research investigated the effects of transition metal oxide doping on the physicalchemical
properties and the multipollutant (ie HgSO2NO) control of a V2O5-WO3TiO2-SiO2 selective
catalytic reduction (SCR) catalyst Additional V Mn and Cu oxides of 5 wt were doped onto the
catalyst surface The doped metal oxides presenting in nanoscales caused an increase in total surface
area of catalysts SEM images suggested that the raw and treated catalysts presenting as bean-shaped
nanoparticles within 10ndash30 nm V4+V5+ Mn4+ and Cu2+ were the major valence states presenting
on the surface of VOx- MnOx- and CuOx-doped catalysts respectively Hg0 oxidation SO2
removal and NO reduction of the SCR catalyst can be enhanced after the metal oxide doping VOx-
and CuOx-doped catalysts not only had excellent Hg0 oxidation but also had great NO reduction
However the enhancement in SO2 removal after metal oxide doping which was assumed to be
partly caused from increasing SO2‒SO3 conversion may be of concern considering the potential
downstream corrosion Langmuir-Hinshelwood model can successfully explain the Hg0 oxidation by
VOx- and MnOx-doped catalysts Overall multipollutant emission control using surface-doped SCR
catalysts can be practically applied at 350 degC under the tested coal-combustion flue gas condition
Another parallel research investigated the effects of copper oxide doping on the
physicalchemical properties and on the multipollutant (ie HgSO2NO) control of a SiO2 porous
composites After Cu surface modification the SiO2 porous composite had surface area of
approximately 4819 m2 g-1 SEM images suggested a fairly uniform distribution of the doped Cu on
the spherical particles having sizes within 500ndash1000 nm XPS results showed that two peaks
corresponding to 9330 and 9348 eV can be assigned to the oxidation states of Cu+ and Cu2+
respectively The CuOx-doped SiO2 composite had greater Hg0 removal efficiency at 150degC than at
350degC
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
37
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-3 Prof Kenjiro Fujimoto Junior Associate Professor
Department of Pure and Applied Chemistry
Faculty of Science and Technology
Tokyo University of Science
Address Yamazaki 2641 Noda Chiba 278-8510 Japan
TEL +81-4-7122-1768
FAX +81-4-7123-9890
Education 2001 PhD Faculty of Science and Technology Tokyo University of Science Thesis Supervisor Guest Professor Mamoru Watanabe (Joint Graduate School Program in National Institute for Materials Science and Tokyo University of Science) 1998 MS Faculty of Science and Technology Tokyo University of Science 1996 BS Faculty of Science and Technology Tokyo University of Science
Professional Experience 2008 ndash Present Junior Associate Professor Faculty of Science and Technology Tokyo University
of Science 2003 ndash 2008 Assistant Professor Faculty of Science and Technology Tokyo University of
Science 2001 ndash 2003 Post-Doctoral Researcher National Institute for Materials Science Japan
Honor and awards (2001~) Best Poster Award 18th International Symposium on the Reactivity of Solid (ISRS-18) (2014) World Young Fellow 2004 Presentation Award Ceramics Society of Japan (2004) 60th Noteworthy Invention Award from Ministry Award of Education Culture Sports Science and Technology (2001) Oral Presentation Award Surface Finishing Society of Japan (2001)
Selected Publication (2010~) Charge-discharge properties of layered-type Li(NiCoTi)O2 powder library Kenjiro FUJIMOTO Keita IKEZAWA and Shigeru ITO Science and Technology of Advanced Materials 12(5) (2011) 054203 High-pressure combinatorial process integrating hot isostatic pressing Kenjiro FUJIMOTO Hiroki MORITA Yuji GOSHIMA and Shigeru ITO ACS Combinatorial Science 15(12) (2013) 622~625 Design of Seebeck coefficient measurement probe for powder library Kenjiro FUJIMOTO Toru TAGUCHI Shogo YOSHIDA and Shigeru ITO ACS Combinatorial Science 16(2) (2014) 66-70 Single crystal growth and structure refinement of hollandite-type K198Fe198Sn602O16 Kenjiro FUJIMOTO Kenji TAKAMORI Yuki YAMAGUCHI and Shigeru ITO Journal of Crystal Growth 390 (2014) 88-91
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
38
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-3 Sep 14 2014 (Sun) 1000-1030 at NTHU BMES R120
High-Throughput Functional Materials Exploration by Combinatorial WetDry Process
Kenjiro Fujimoto
Department of Pure and Applied Chemistry Faculty of Science and Technology
Tokyo University of Science Japan
Exploration of functional materials have increasingly focused on multi-element structures such as
high-temperature superconductor and magnetic dielectric or catalytic materials When exploring materials of
these types much information has to be collected on their synthesis route parameters This process of
information collection can be very time consuming as the material samples take a good deal of time and raw
materials to prepare using conventional methods Until now we have developed high-throughput materials
exploration system in order to improve the above problem1) Fig1 is the photograph of the materials
exploration system ldquordquoM-ist combirdquo based on the electrostatic spray deposition method which is one of
solution process By using the robot system and accessory devices we got various functional materials data
As an example Li-Ni-Co-Ti oxides library was prepared using the ldquoM-ist combirdquo system and established its
reaction phase diagrams from phase identification of X-ray diffraction and chemical composition analysis data
Our research group explored newly candidate cathode materials for lithium ion secondary battery with layered
rock-salt type structure Newly layered rock-salt type Li(NiCoTi)O2 were found from obtained powder
library heated at 700˚C for 10 hours in air atmosphere And LiNixCo09-xTi01O2 (0lexle06) compounds
showed good cycle property among Li(NiCoTi)O2 library2)
And recently we developed newly combinatorial materials exploration process which was integrated the
existing robot system as ldquoM-ist combirdquo and the hot isostatic pressing (HIP) apparatus By using newly process
we succeeded speeding up materials preparation under high-pressure (~200 MPa)
Fig 1 Schematic image and photograph of the high-throughput materials exploration system
1) K Fujimoto H Takahashi S Ito S Inoue and M Watanabe Appl Surf Sci 252 (2006) 2446-2449
2) K Fujimoto K Ikezawa and S Ito Sci Tech Adv Mater 12(5) (2011) 054203
3) K Fujimoto H Morita Y Goshima and S Ito ACS Combinatorial Science 15(12) (2013) 622~625
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
39
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-4 Prof Fu-Hsiang Ko Professor
Institute of Nanotechnology Department of Materials Science and Engineering
National Chiao Tung University
Address Department of Materials Science and Engineering Engineering
Building VI Room 357 Hsinchu City Taiwan
TEL (886) 35712121ext 55803
Education 1996 PhD Department of Atomic Science National Tsing Hua University Taiwan 1991 MS Department of Chemistry National Taiwan Normal University Taiwan 1989 BS Department of Chemistry National Tsing Hua University Taiwan
Professional Experience 20142 ndashpresent Associate Dean Office of Student Affairs National Chiao Tung University Taiwan 20137 ndash20141 Visiting Professor California Institute for Telecommunications and Information Technology University of California Irvine CA USA 20078 -present Professor Institute of Nanotechnology Department of Material Science and Engineering National Chiao Tung University Taiwan 20052 -20077 Associate Professor Institute of Nanotechnology National Chiao Tung University Taiwan 20021-20051 Researcher National Nano Device Laboratories National Applied Research Laboratories 199610-200112 Associate Researcher National Nano Device Laboratories NARL Taiwan 200010-200212 and 20042-20051 Department Manager National Nano Device Laboratories NARL
Honor and awards (2009~) Excellent Research Award College of Engineering National Chiao Tung University (2009 2010) NCTU Research Award Ministry of Science and Technology (2011 2012 2013 2014)
Selected Publication (2010~) Y-W Huang C-S Wu C-K Chuang S-T Pang T-M Pan Y-S Yang and F-H Ko Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Polycrystalline Silicon Nanowire Field-Effect Transistor Biosensor Anal Chem v85 7912minus7918 (2013) J S Meena M-C Chu Y-C Chang H-C You R Singh P-T Liu H-P D Shieh F-C Chang and F-H Ko Effect of oxygen plasma on the surface states of ZnO films used to produce thin-film transistors on soft plastic sheets J Mater Chem C v1 6613-6622 (2013) S Ravipati J Shieh F-H Ko C-C Yu and H-L Chen Ultralow reflection from a-Si nanograssSi nanofrustum double layers Adv Mater v25 1724-1728 (2013) J S Meena M-C Chu Y-C Chang C-S Wu C-C Cheng F-C Chang F-H Ko Novel Chemical Route to Prepare a New Polymer Blend Gate Dielectric for Flexible Low-voltage Organic Thin-Film Transistor ACS Applied Materials amp Interfaces v4 3261-3269 (2012) [selected as the cover art of July issue] C-T Wu C-H Lin C Cheng C-S Wu H-C Ting F-C Chang and F-H Ko Design of Artificial Hollow Moth-Eye Structures Using Anodic Nanocones for High-Performance Optics Chem Mater v22 6583-6589 (2010)
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
40
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-4 Sep 14 2014 (Sun) 1050-1120 at NTHU BMES R120
Facile Manufacturing on Energy-efficient Devices with Flexibility and Antireflection
Fu-Hsiang Ko
Department of Materials Science and Engineering Institute of Nanotechnology NCTU
In this lecture we would like to introduce soft devices with energy-efficient manufacturing and
Nanostructure surface with low reflectivity In the first part low voltage organic thin film transistor
with low temperature manufacturing is proposed In addition to having low-temperature fabrication
these polymer blend gate dielectric materials have satisfied other stringent requirements for an
optimal flexible device excellent insulating properties non-toxic surface free of pin-hole defect
compatibility with organic semiconductors and mechanical flexibility This process for existing
contributors can make drastic changes via low-cost low-temperature processing and pervasive
electronic applications such as flexible displays and radio frequency identification (RFID) tags In
the second part two types of surface manufacturing are demonstrated with efficient antireflection
We demonstrate an innovative approach for the fabrication of self-organized hollow-to-solid
nanocone arrays using a decoupling two-step anodization of AlTa interlayer on a substrate The
porosity of the hollow nanostructures is tunable by the deposited thickness of Ta film In addition we
demonstrate that unique double-layered nanostructures comprising amorphous silicon nanograss
(a-Si NG) on top of silicon nanofrustums (Si NFs) behave as almost perfect optical absorbers The
a-Si NGSi NF structured materials exhibite ultralow reflectance and near-perfect optical absorption
across a wide spectral range (300ndash800 nm) moreover their responses toward transverse electric
(TE)ndash and transverse magnetic (TM)ndashpolarized incident light are almost indistinguishable over a
wide range of angles of incidence (AOIs from 20 to 60deg) making them ideal optical absorber
candidates for solar cell applications
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
41
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-5 Prof Naoto Kitamura Junior Associate Professor
Faculty of Science and Technology Tokyo University of Science
Address 2641 Yamazaki Noda Chiba 278-8510 Japan
TEL +81-4-7122-9495
FAX +81-4-7123-9890
Education 2006 PhD Graduate School of Science Kyoto University Japan
Thesis Supervisor Professor Teiichi Hanada
2003 MS Graduate School of Human and Environmental Studies Kyoto University Japan
2001 BS Faculty of Integrated Human Studies Kyoto University Japan
Professional Experience 2014 -present Junior Associate Professor Faculty of Science and Technology Tokyo University of
Science Japan
2012 -2013 Senior Research Fellow Department of Physics Tampere University of Technology
Finland
2007 -2014 Assistant Professor Faculty of Science and Technology Tokyo University of Science
Japan
2006 -2007 Researcher Graduate School of Human and Environmental Studies Kyoto University
Japan
Selected Publication (2010~) Protonic Conduction Crystal and Electronic Structures of La09Ba11Ga095Mg005O4- N
Hamao N Kitamura T Itoh N Igawa and Y Idemoto Solid State Ionics 253 123-129 (2013)
Local Structure Analysis on (LaBa)(GaMg)O3- by the Pair Distribution Function Method Using
a Neutron Source and Density Functional Theory Calculations N Kitamura SC Vogel and Y
Idemoto Solid State Communications 163 46-49 (2013)
Oxide-Ion Conduction Average and Local Structures of LaSrGa1-xMgxO4- with Layered
Perovskite Structure N Kitamura N Hamao SC Vogel and Y Idemoto Electrochemistry 81
448-453 (2013)
Dependence of Property Cathode Characteristics Thermodynamic Stability and Average and Local
Structures on Heat-Treatment Condition for LiNi05Mn05O2 as a Cathode Active Material for
Li-Ion Battery N Kitamura Y Hasegawa Y Uchimoto K Amezawa and Y Idemoto
Electrochimica Acta 56 9453-9458 (2011)
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
42
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-5 Sep 14 2014 (Sun) 1120-1150 at NTHU BMES R120
Proton Distribution and Dynamics in BaZrO3-Based Proton Conductor for Solid Oxide Fuel Cell
Naoto Kitamura
Faculty of Science and Technology Tokyo University of Science
I have investigated ion-conducting crystalline materials which can be applied for
electrochemical devices such as the solid oxide fuel cell (SOFC) and the lithium-ion battery (LIB)
Especially special attention has been paid to distribution of the conduction species in crystals
because it should be related with the electrical properties ie ionic conductivities In case of a
material with high conductivity conducting ions may behave as ldquoions in liquidrdquo even though a host
atomic arrangement is a rigid crystal This means that one have to determine a periodicity of atomic
configuration (a host crystal) and a random structure (distribution of conducting ions) simultaneously
In order to achieve this I have tried the reverse Monte Carlo (RMC) simulation using neutron and
synchrotron X-ray total scatterings as well as the Bragg reflections As another approach from the
theoretical viewpoint the molecular dynamics (MD) simulation where forces acting on atoms are
estimated by the density functional theory (DFT) ie DFT-based MD has been also performed
One of my recent works has applied these simulation techniques for doped BaZrO3 with the
perovskite structure which are expected to be commercialized as an electrolyte of SOFC [1] It is
well-known that the material exhibits high proton conductivity at elevated temperature around 500
oC but the conductivity depends on the dopant significantly In order to discover the underlying
reason of the dopant effect the DFT-based MD simulation on a protonated Ba(ZrYZn)O3 was
carried out (Fig 1) The result demonstrates that the apparent diffusion coefficient of proton is 13 x
10-5 cmmiddotsec-1 at 800 oC and some protons tend to get
trapped by Zn dopants considerably It was also found
from the RMC modelling that such an atomic
configuration with the protons trapped by Zn can explain
well the experimentally-obtained structure factors S(Q)
as well as Bragg reflection Electronic-structure analysis
by the DFT calculation reveals that the differences in the
effective charges between Zr and the dopants explain the
strong proton trapping by Zn
Reference
[1] N Kitamura J Akola S Kohara K Fujimoto Y
Idemoto J Phys Chem C submitted Fig 1 Proton diffusion in Ba(ZrYZn)O3
simulated by the DFT-based MD
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
43
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speaker C-6 Prof Zong-Hong Lin Assistant Professor
Institute of Biomedical Engineering National Tsing Hua University
Address 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan
TEL +886 (3) 5715131 Ext 35502
FAX +886 (3) 5162595
Education 2005ndash2009 PhD Department of Chemistry National Taiwan University Thesis Supervisor Professor Huan-Tsung Chang 2003ndash2005 MS Department of Chemistry and Biochemistry National Chung Cheng University Taiwan 1999ndash2003 BS Department of Chemistry National Chung Cheng University Taiwan
Professional Experience 2014ndashPresent Assistant Professor Institute of Biomedical Engineering National Tsing Hua University Taiwan 2012ndash2014 Postdoctoral Researcher School of Materials Science amp Engineering Georgia Institute of Technology USA 2010ndash2012 Postdoctoral Researcher Department of Chemistry National Taiwan University Taiwan 2009ndash2010 Second Lieutenant Taiwan Army
Honor and awards (2009~) Honorary Member the Phi Tau Phi Scholastic Honor Society of the Republic of China (2009) Thesis Award in Applied Chemistry Chemical Society Located in Taipei Taiwan (2009) Thesis Award Chi Lin Technology Co Ltd (2009) The Deanrsquos Award College of Science National Taiwan University (2009)
Selected Publication (2010~) A Self-Powered Triboelectric Nanosensor for Mercury Ion Detection Z-H Lin G Zhu Y S Zhou Y Yang P Bai J Chen Z L Wang Angewandte Chemie International Edition 52 5065-5069 (2013) Water-Solid Surface Contact Electrification and its Use for Harvesting Liquid Wavy Energy Z-H Lin G Cheng L Lin S Lee Z L Wang Angewandte Chemie International Edition 12512777-12781 (2013) Enhanced Triboelectric Nanogenerators and Triboelectric Nanosensor using Chemically Modified TiO2 Nanomaterials Z-H Lin Y Xie Y Yang S Wang G Zhu Z L Wang ACS Nano 7(5)4554-4560 Harvesting Water Drop Energy by a Sequential Contact Electrification and Electrostatic Induction Process Z-H Lin G Cheng S Lee Z L Wang Advanced Materials 26(27)4690-4698 (2014) Dual-Mode Triboelectric Nanogenerator for Harvesting Water Energy and as a Self-Powered Ethanol Nanosensor Z-H Lin G Cheng W Wu K C Pradel Z L Wang ACS Nano 8(6)6440-6448 (2014) Triboelectric Nanogenerator as an Active UV Photodetector Z-H Lin G Cheng Y Yang Y S Zhou S Lee Z L Wang Advanced Functional Materials 24(19)2810-2816 (2014)
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
44
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Invited Speech C-6 Sep 14 2014 (Sun) 1150-1220 at NTHU BMES R120
Harvesting Water Energy by a Sequential Contact-Electrification and Electrostatic-Induction Process
Zong-Hong Lin
Institute of Biomedical Engineering National Tsing Hua University Taiwan
Contact electrification also called triboelectrification is a well-known phenomenon that occurs when two materials are
brought into contact and has been demonstrated in applications such as metal ions reduction electrostatic charge
patterning chemical sensors and laser printing Recently this phenomenon has been used to collect energy from
environmental sources in the form of the triboelectric nanogenerator (TENG) The working mechanism of the TENG is
based on a combination of contact electrification and electrostatic induction Contact between two materials with
different triboelectric polarity will cause surface electronionmaterial transfer and create an electric potential difference
after separation By cyclically contacting and separating materials with oppositely charged surfaces electrons can be
driven to flow through the external load and generate a continuous output Until now TENG is designed to work between
solid materials and works best under dry conditions However the water-related energy sources including ocean waves
waterfalls and rainwater in the environment have abundant amounts of energy which are inexhaustible and can be good
alternatives to solar energy Actually tribolelectricity does exist when liquids are flowing through insulating tubes For
example a voltage variation rising up to 300 mV is observed when deionized water flows through a 1 m-long rubber tube
Or a surface charge density of 45 μCthinspmminus2 is measured on each water droplet pipetted from a polytetrafluoroethylene
(PTFE) tip Therefore herein we explore the opportunity to use water itself as one type of ldquomaterialrdquo choice for TENG
We demonstrate that the contact electrification between water and insulating polymer films can also be a useful strategy
for TENG design which can derive a new application of TENG especially in liquid environments for energy harvesting
and sensing
We develop the water-TENG with a superhydrophobic micro-nanostructured polytetrafluoroethylene (PTFE) surface to
harvest the water-related energy from flowing water and water drop By studying the relationship between the motion of
single water drop onto the water-TENG and the measured output a sequential contact-electrification and
electrostatic-induction process is proposed to describe the working mechanism of the water-TENG The output of the
water-TENG generated from a 30-μL water drop can achieve a peak voltage of 93 V and a peak current of 17 μA A
maximum output power of 145 μW is observed when the water-TENG is connecting to a load resistor of 5 MΩ The
water-TENG is also utilized to collect energy from flowing tap water from a household faucet and the output current and
instantaneous power densities reach 15 μA cmminus2 and 20 mW cmminus2 respectively The output can be used to directly
drive 20 light-emitting diodes (LEDs) instantaneously Moreover we design a system containing the water-TENG and a
packaged contact-TENG to effectively collect electrostatic and mechanical energy from spray water drop The rectified
outputs have been demonstrated to charge commercial capacitors
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
45
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster Paper
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-01 Pharmaceutical iron oxide nanoparticles functionalized as three-in-one agent of photothermal therapy radical scavenging and MRI contrast enhancement 張博揚 Institute of Biophotonics National Yang-Ming University
PA-02 Photo-Responsive Lactoferrin-Coated Nanopeas with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy 林建廷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-03 One-and two-step synthesis of methylene blue-involving Au nanoparticles for surface enhanced Raman scattering and photodynamic therapy 鄭乃綺 Department of Applied Chemistry National University of Kaohsiung
PA-04 Thermoresponsive polymer grafted polystyrene monolithic capillary column for microanalysis of bioactive compounds 郡山拓也 Department of Materials Science and Technology Tokyo University of Science
PA-05 rGOSilk Microfiber Platform Integrating Chemical Cues and Electrical Stimulation for Guiding One-Dimensional Neuron-Like Cell Growth and Neurite Sprouting 廖家瑩 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-06 Multifunctional HTPGSGraphene Quantum Dots-based Double Stimuli-Responsive Nanotheranostics for Cancer Thermal-Chemo-therapy 蘇昱璘 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-07 Magnetic field-Controlled Release of Paclitaxel from Gelatin-coated Mesoporous Magnetic Nanosphere for Deep Tumor Therapy 盧益晟 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-08 Robust ICGPEI-Encapsulated Polymeric Micelles for Cancer Imaging and Photothermal Therapy 簡維宏 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-09 Co-Delivery of Chemotherapy and Photothermal Therapy by pH-Responsive Polymeric Nanoparticles for Improved Cancer Treatment 侯楷亭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-10 Preparation of stimuli-responsive micro-gel composed of three-armed oligo(ethylene glycol) for controlled release of protein drug 山脇幸也 Department of Materials Science Tokyo University of Science and Technology
PA-11 Core design of thermoresponsive nanospheres with well-defined corona layer for diagnosis 松山拓矢 Department of Materials Science and Technology Tokyo University of Science
PA-12 Tumortropic Adipose-Derived Stem Cells Carrying Smart Therapeutic Nanoparticles for Targeting Delivery and Chemotherapy of Glioblastoma 林意文 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-13 Effects of Property of Glass Filter Prepared using Micro Glass-Beads on Filtration of Polystyrene Spheres as Model Cells 齋藤理玖 Department of Materials Science and Technology Tokyo University and Science
PA-14 LSPR Sensing Property of Gold Nanoparticle Loading Titania-Glass Composite Film 富田祥平 Department of Materials Science and Technology Tokyo University and Science
PA-15 Change in structural color of block copolymer films by observation angle 上木 ひろみ Department of Materials Science and Technology Tokyo University and Science
PA-16 pH-Responsive Hierarchical Transformation of Cationic Lipid Assemblies within Anionic Polyelectrolyte Gel Surface Layer Surrounding Magnetic Core Particle for Applications in Controlled Drug Release and MR Imaging Contrast 黃汶嘉 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-17 Doxorubicin Encapsulated AlbuminGold Nanorod Hybrids for Cell-Mediated Tumoritropic Delivery 邱顯庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-18 Fabrication of PHNPsadenineAu hybrid nanoparticles by coordinated polymerization in biomedical application 魏子強 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-19 Trojan-Horse Nanocapsules Encapsulating β-CD Paclitaxel for On-Command Intracellular Drug Delivery 林宜潔 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-20 Enhanced surface-enhanced Raman scattering photothermal therapy and photodynamic therapy by novel plasmonic AuAg hollow nanospheres 林沛樺 Institute of Biophotonics National Yang-Ming University
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
46
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session A (PA) Biomaterials PA-21 Improving Delivery of Y2O3 Nanoparticles by Macrophages for Brain Tumor Imaging 李奕楠 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-22 Microenvironments in different stages of astrocytoma progression 林久民 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-23 Nucleic Acid Delivery of PolymerGoldNanorod Complexes 莊鈞喬 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-24 Bioreducible PolyethylenimineSPIO Nanocomplexes as A Theranostic Gene Carrier for Efficient Magnetofection and Magnetic Resonance Imaging 黃日揚 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-25 One-step synthesis Core-shell Nanocapsules Stabilized by Single-Component Protein for drug delivery 李昀庭 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PA-26 YOF modification on Y2O3Yb3+Er3+nanophosphorsfor enhanced near-infrared fluorescence intensity 神谷圭亮 Department of Materials Science and Technology Tokyo University of Science
PA-27 An Online Open-Tubular Fractionation Scheme Coupled with Push-Pull Perfusion Sampling for Profiling Extravasation of AuNPs in a Mouse Tumor Model 曾柏仁 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
47
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Poster 20140914 (Sun) 1330~1530
Poster Session B (PB) Biomedical Imaging PB-01 Helicity analysis for Marfan syndrome by 4D flow MRI RED classification 陳品蓁 Interdisciplinary Program of Life Science National Tsing Hua University
PB-02 Analysis of Septal Flattening for Repaired Tetralogy of Fallot Patient 張孟筑 Interdisciplinary Program of Nuclear Science National Tsing Hua University
PB-03 Improvement of Image Quality with an Image Denoising Technique for Posterior-anterior Kilovoltage Portal Image in Lung Radiotherapy 許哲綸 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-04 Estimation of Average Glandular Dose Using PMMA Phantoms for Diffident Mammographic Units 朱書儀 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-05 Investigation of Physical Characteristics of Bolus Material in Mammography 趙俞婷 Department of Medical Imaging and Radiological Sciences Chung Shan Medical University
PB-06 Unfocused Ultrasound Transducer Based Optical Resolution Photoacoustic Microscopy for Micro-vasculature Imaging 楊哲昌 Department of Electrical Engineering National Tsing Hua University
PB-07 Observation of Unstained Biological Tissue by Transmission FT-IR Microscopy 山本佳奈子 Department of Materials Science and Technology Tokyo University of Science
PB-08 in vivo Imaging of Cancer Metastasis by Using Near-Infrared Fluorescence Nanophosphors 福島理人 Department of Materials Science and Technology Tokyo University of Science
PB-09 Development of nanothermometer based on near-infrared emission of rare-earth doped ceramic nanophosphors 松本泰来 Department of Material Science Tokyo University of Science
Poster 20140914 (Sun) 1330~1530 Poster Session C (PC) Science and Technology for Environment amp Energy
PC-01 Photocatalytic degradation of organic dye RhB by cobalt cocatalyst dispersed on strong and weak sites of hematite nanoparticles 洪薪婷 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-02 Investigating Calcium-Humic Acid Complex Fouling on Nanofiltration Membrane 陳以諾 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-03 Development of Laser Patterning for the Fabrication of Biodegradable Polymeric Microfluidic Systems 黃玟玲 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-04 Solid-Phase Extraction Coupled with Vortex-Assisted Liquid-Liquid Microextraction for the Determination of Trace Strontium in Water Samples 王敬懿 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-05 Effect of Ta addition on the magnetic properties of melt-spun SmCo5 magnets 齋藤勇児 Department of Materials Science and Technology Tokyo University of Science
PC-06 Characterization and magnetic properties of thin ribbons of fcc-Co fabricated by melt-spinning 藤本泰史 Department of Materials Science and Technology Tokyo University of Science
PC-07 Evaluation of mechanical properties of Mg2Si with metal binders 亀山知季 Department of Materials Science and Technology Tokyo University of Science
PC-08 Strength evaluation of Mg2Si thermoelectric materials 佐藤俊輔 Department of Materials Science and Technology Tokyo University of Science
PC-09 High pressure synthesis of Na3M(PO4)2(M=Cr V) and their electrochemical properties 垣内幸恵 Department of Applied Electronics Tokyo University of Science
PC-10 Synthesis of new polyanion-type Na3Fe(PO4)2 cathode material 松原稜 Department of Applied Electronics Tokyo University of Science
PC-11 Characteristics and cytotoxicity of particulate matters (PMs) emitted from a hospital solid waste incinerator towards A549 cell 林彥良 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University
PC-12 Electrochemical properties of CaFe2O4 type LiMn2-xTixO4(x=002) 奥平健太郎 Department of Applied Electronics Tokyo University of Science
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
48
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Ministry of Science and Technology (MOST) paper
No Topic Authors MOST grant no
MOST-01 Folate conjugated Reducible PEI-CdotssiRNA as
Theranostic Nanoagent for Lung Cancer Treatment
Yu-Fen Wu
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-02 Redox and pH Dual Responsive Self-assembling
Hyaluronic Acid Carrier with Active Targeting
LHRH Peptide for Cancer Therapy
Chun-Jui Lin
Tzu-Wei Wang
MOST 100-2628-E-007 -022 -MY3
MOST 102-2320-B-007 -006 -MY2
MOST-03 A Comparison of Image Priors in PET Image
Reconstruction
Ling Chi Huang
Po Chia Huang
Ching han Hsu
MOST 102-2221-E-007-021-MY2
MOST-04 Three-Dimensional Median Root Prior Image
Reconstruction for Small Animal Pinhole SPECT
Po-Chia Huang
Ching-Han Hsu
MOST 102-2221-E-007-021-MY2
MOST-05 Protein-Graphene-Protein Drug Capsules with Dual
Targeted and Heat-Triggered Characterizations for
Enhanced Tumor Therapy
Jen-Hung Fang
San-Yuan Chen
Shang-Hsiu Hu
MOST 102-2218-E-007 -014
MOST-06 Targeted Mesoporous Iron-Oxide Nanoparticles
Encapsulated Perfluorohexane (PFH) and
Hydrophobic Drug for Deep Tumor Penetration and
Therapy
Yi-Sheng Lu
Jen-Hung Fang
Shang-Hsiu Hu
MOST 103-2221-E-007 -031 -MY3
MOST-07 Improving Diffusion Distance by Vascular
Destruction of Droplets with Multi-Ultrasound
Irradiation
Yi-Ju Ho and
Chih-Kuang Yeh
MOST 101-2221-E-007 -035 -MY3
MOST-08 Smart Magnetic Nanocarriers for Targeting
Colorectal Cancer and Drug Controlled Release
Ting-Yu Liu
Chih-Yu Kuo
Tzu-Yi Chan
Kuan-Syun Wang
MOST 103-2221-E-131-019
MOST-09 Multi-function microbubbles combined with focused
ultrasound for hemiparkinsonian animals model
theranosis
Ching-Hsiang Fan
Chien-Yu Ting
En-Ling Chang
Chih-Kuang Yeh
MOST 102-2221-E-007 -020 -MY3
MOST-10 3D Conducting Polymer-based Bioelectronic
Interface as a Universal Personalized Predictive
Medicine Platform for Cancer Diagnostics
Yu-Sheng Hsiao
Hong-Xin Yan
Hsiao-hua Yu
Hsian-Rong Tseng
Peilin Chen
MOST 103-2221-E-131-002-MY2
MOST-11 Enhancement of Cancer Therapy Efficacy by
Trastuzumab-conjugated and
pH-Sensitive Nanocapsules with the Simultaneous
Encapsulation of Hydrophilic and Hydrophobic
Compounds
江智聖
胡尚秀
張源清
陳三元
MOST 102-2221-E-009 -023 -MY3
MOST-12 Intelligent nanovehicles functionalized with
tumor-acidity-triggered surface charge transition and
active tumor targeting for promoted intracellular drug
delivery
Ting-Wei Yu
Chia-Chian Hung
Hsin-Cheng Chiu
Wen-Hsuan
Chiang
MOST 102-2218-E-007-007
MOST-13 Biodegradable Polymeric Nanoparticles with
pH-Responsive Surface Charge Transition for
Efficient Delivery of Indocyanine Green
LT Ting CC
Hung HC Chiu
WH Chiang
MOST 103-2221-E-007 -023
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
49
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
MOST-14 Lipid-containing hybrid nanoparticles functionalized
with guidable delivery of MRI contrast agentcocktail
therapy dual stimuli-controlled release and
endosomal escape ability for overcoming tumor
multidrug resistance
Wen-Chia Huang
Yi-Wen Lin Te-I
Liu and
Hsin-Cheng Chiu
MOST 102-2221-E-007 -133 -MY3
MOST-15 Using tumor-tropic monocytes as a vehicle system
for upconverting light-activated photodynamic
therapy of primary solid tumors
Wen-Chia Huang
Yuan-Chung Tsai
Chu-Wei Huang
and Hsin-Cheng
Chiu
MOST 102-2221-E-007-032-MY3
MOST-16 Characteristics and cytotoxicity of particulate
matters (PMs) emitted from a
medical solid waste incinerator towards A549
cell
Yang-Liang Lin
Yuh-Jeen Huang
MOST 103-2221-E-007-006-MY3
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo
50
Proceeding of 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science
Memo