CHILD NEUROLOGY TOPICS Acute and Long-Term Side Effects of Antineoplastic Treatment
in Children Hanefeld F, Harten G, Langermann H-J, Riehm H, Stephani U . ............ .
Well-known and Less Well-known Malformations of the Hindbrain. Their Morphology and Relationship to "Malformation" Hydrocephalus Schmitt HP . .................................................... .
SYMPOSIA
Problems in Perinatal Neurology - Diagnosis of Neonatal Brain Damage Preface: Present Situation and Future of Perinatal Neurology
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Sakamoto Y, Watanabe K . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 139 Diagnosis of Neonatal Central Nervous System Infections
ToriiS ................................................. 139 Diagnosis of Neonatal Bacterial Meningitis
Two-dimensional Ultrasonography of the Brain in Infancy: Its Application to the Diagnosis of Intracranial Disorders Yokochi K, Hokazono Y, Inukai K ...... .... . .... ............... 141
Neurophysiological Examinations for the Diagnosis of Perinatal Brain Damage Watanabe K, Inokuma K, Takeuchi T, Negoro T . . . . . . . . . . . . . . . . . . . . .. 142
Electrophysiological Diagnosis in Newborn; Clinical Applications of Auditory Brainstem Response and Blink Reflex Yasuhara A, Yamada A, Kinoshita Y, Matsumura T. . . . . . . . . . . . . . . . . . . . 143
1. Experimental Developmental Neurobiology Regional Membrane Phospholipid Composition in Developing Rat
Brain after Premature Birth Yokota K, Yamaguchi T .... ............... .. . . .............. 146
2 Effect of Theophylline on Myelination in the Brain of Young Rats Kamigaki M, Sunaga S, Sato Y, Okuyama K . . . . . . . . . . . . . . . . . . . . . . . .. 146
3 Enzyme-Linked Immunoadsorbent Assay for Myelin Basic Protein Tanaka K, Tomida N, Tanaka M, Sasahara A, Yamamoto H, Shimada M .............................................. 147
4 Prevention of Brain Dysfunction by Supplementary Zinc in Rat with Fetal Alcohol Syndrome: Effect on RNA and Protein Contents and Appearance of Confronting Cisternae Tanaka H, Inomata K, Arima M . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 147
5 Effects of Phenytoin on Mouse Purkinje Cells-Comparison between Infantile and Adult Mice Suzuki M, Tamai!, Ohta H, Maekawa K ...... . . . ................. , 148
6 Synaptic Changes in Purkinje Cell Dendritic Spines of Mouse Cerebellum after Neonatal Administration of Cytocine Arabinoside Ohno M, Kawasaki H, Utsunomiya T, Abe Y, Yamano T, Shimada M . . . . . . .. 148
8 Effects of Early Malnutrition and Rehabilitation on Brain Development -Golgi-Cox Study Yoshida A, Yoshioka H, Kasubuchi Y, Kusunoki T . . . . . . . . . . . . . . . . . . . . 149
9 Biochemical Study of Experimental Microcephaly. III. Developmental Changes in Catecholamines, Serotonin and GABA in Experimental Microcephaly Yamasaki S, A be Y, Oya N, Shimada M ... .. .. . .. .... ........... .. 150
II. Human Development 10 Posture of Kindergarten Children and Its Relationship to Behavioral
11 Latency and Persistence of Fersen Reflex in Infants Futagi Y, Ohtani K, Tanaka J, Shimizu H . . . . . . . . . . . . . . . . . . . . . . . . . . 151
12 Effects of Posture on the Functional and Postural Laterality of Pre-Term Infants in the Early Life Konishi Y, Mikawa H ................... . ................... 151
94 Brain & Development, Vol 6, No 2, 1984
13 The Passive Range of Motions in Developmentally Disabled Children Kisa T, Nakao Y . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 152
14 Method of Feeding in Infancy and the Psychomotor Development at Preschool Age Mukai Y . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 152
15 An Attempt at Systematic Understanding of Benign Hypertonia and Dystonia in Infancy Kitazumi E, Enomoto S, Yokochi A, Yokochi K, Uchida T, Kodama K . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 153
16 Effects of Neonatal Hypoxia on Brain Development III. Behavioral Changes due to Total Asphyxia Yoshioka H, Ochi M, Yoshida A , Iino S, Fujiwara K, Ishimura K, Nishimura 0, Kusunoki T . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 153
17 Postural Changes in Ventral Suspension during the Neonatal Period and Early Infancy Morikawa Y, Sai H, Hino T, Fujita H, Izumi H, Kimura K, Miyoshi K, Mizuta R . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 154
III. Neurophysiological Diagnostics 18 A Study on Pathophysiology of Myoclonus - Polysomnographical
Examination Yonezawa M, Tada H, Hasegawa M, Nomura Y, Segawa M, Yamashita K, Tanaka S . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 154
19 An Electroencephalographic Study on Uncommon Chromosomal Abnormalities Nishibayashi N, Inouye H . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 155
20 A Clinical Study of EEG Power Spectra in Children with Hemiplegia -Prognostic Correlation to Similarity between the Two Hemispheres Fujiwara J, Kawashima K, Nakahara S, Nakata Y . . . . . . . . . . . . . . . . . . . . . ISS
21 On the Effects of Pentoxifylline upon the EEG Activity of Early Infantile Autism: Quantitative Pharmaco-Electroencephalographic Study Suzuki M, Nakazima K, Sugiyama A, Nakashita Y, Ogawa T . . . . . . . . . . . . . . 156
22 Analysis of Swallowing Disturbance in Cerebral Palsy by Superficial EMG and Respiratory Curve Analysis Hirayama Y, Takagi A , Wash ida T . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 156
23 The Correlation of Waveform between Fontanelle Pressure and Systemic Pressure - Observation of Waveform during Operations for Congenital Heart Disease Nakashima 0 , Shirouzu T, Kuramoto N . ... . . . . . . . . . . . . . . . . . . . . . . . 157
24 Normal Conduction Velocity of the Tibial Nerve in Children Abe J, Mimaki T, Onoe S, Tagawa T, Ono J, Yabuu chi H, Sugita T .. ....... 157
25 Topographic Mapping of Brainstem Auditory Evoked Responses in Humans Shimizu N, Hirasawa K ................ . ... . ................. 158
27 A Visual Evoked Potential Study in Sturge-Weber Syndrome Iinuma K, Suzuki K, Ich inohasama Y, Hayamizu S . . . . . . . . . . . . . . . . . . . . 159
28 A Clinical Study of Short Latency SEP in Patients with Brain Dysfunction Kasagi S, Takakura H ..... . ... .. .. ... ..... . . ........ . .... ... 159
29 Developmental Change of Interhemispheric Coherence in Children Tomita Y, Kato E, Mori C, Abe K .... .. . . . . . . . . . . . . . . . . . . . . . . . .. 160
31 A Long-Term Polygraphic Study Using Ambulatory EEG Monitoring - Apneic Spells in a Case of Arnold-Chiari II Malformation during the Day and Night Kumagai K, Kureha Y, Obata J, Niwa N, Okuyama M, Horita H, Maekawa K . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 161
33 Developmental Study of the T-Wave of Achilles Tendon Reflex in Children Takakura H, Kasagi S ....................................... 162
34 The Auditory Evoked Palpebral Reflex: Clinical Application to Neonatal Brain Dysfunction Yamada A, Yasuhara A, Kinoshita Y, Matsumura T, Yasuhara M . . . . . . . . . . . 162
35 An Electrophysiological Study of Early-Infantile Epileptic Encephalopathy with Suppression-Bursts Yasuhara A, Yamada A, Kinoshita Y, Sugimoto T, Matsumura T . . . . . . . . . . . 163
40 Short Latency Somatosensory Evoked Potentials in Patients with Anticonvulsant Therapy Tayama M, Hashimoto T, Kawano N, Hiura K, Suzue J, Endo S, Fukuda K, Mori A, Fuzino K, Miyao M . . . . . . . . . . . . . . . . . . . . . . . . . . . 165
41 Developmental Changes of Topographic EEG Features in the Newborn Inokuma K, Watanabe K, Negoro T . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 166
42 Follow-Up Study of Neurologically Abnormal Infants Using the Auditory Brain Stem Response Part I: Process to Spastic Paralysis in Infants with One-Sided Deafness KoikeK ................................................ 166
43 Polygraphic Studies of Abortive Sudden Infant Death Syndrome Fukuda K, Mori A, Tayama M, Endo S, Suzue J, Hiura K, Kawano N, Hashimoto T, Miyao M .............................. 167
44 Development of Sleep Spindles in Normal Children - With Reference to Change in Their Distribution Miyajima T, Ogihara M, Hoshika A, Matsuno T, Honda T . . . . . . . . . . . . . . . . 167
45 The Effect of Neonatal Hyperbilirubinemia on the Auditory Brainstem Response Kuriyama M, Konishi Y, Mikawa H . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 168
47 On a Quantitative Method to Measure Cerebral Blood Flow in Newborn Infants (I) Ishiwa S, Gotoh K, Ono Y, Ogawa T ............................. 169
48 Auditory Brainstem Evoked Responses in Down Syndrome Miyao M, Yamamoto Y, Kamoshita S, Nihei K . . . . . . . . . . . . . . . . . . . . .. . . 169
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V. 55
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Neuroradiological Study of Human Brain in the Fetal Period Imanishi M, Tanikake T, Kyoi K, Utsumi S, Fukuzumi A, Iwasaki S, Otani R ........................................ .
The Morphometrical Changes Seen on Computed Tomography with Increasing Age in Down Syndrome: Small Posterior Fossa and Calcification of the Globus Pallidus Ieshima A, Kisa T, Yoshino K, Takashima S, Takeshita K ............... .
Subdural Effusion (Hematoma) Accompanied by Enlargement of Subarachnoid Spaces in Infancy Aoki N, Masuzawa H, Sato J .................................. .
Evaluation of Shunt Patency Sato J, Masuzawa H, Mirna T, Inoue T ........................... .
Classification of Low Density Areas in the White Matter on Computerized Tomography Narazaki 0, Hanai T, Fukuda M ............................... .
Positron Emission CT in Childhood Epilepsy Michihiro N, Utsumi Y, Ariizumi M, Sato K, lio M ................... .
Congenital Anomalies of the CNS Slit Ventricle as a Shunt Complication - Some Considerations on
Pathogenesis and Therapeutic Problems in the Developing Brain Sato N, Sato H, Hojo H, Yamasaki S, Tamaki N, Matsumoto S ........... .
Cerebral Malformation of Thanatophoric Dwarfism: Including a Golgi Study Shigematsu H, Otani K, Takashima S, Ieshima A ..................... .
Pathology of Holoprosencephaly on Immunohistochemical Observation of Heterotopic Glioneural Tissue in the Subarachnoid Space Tanaka J, Takada K, Ito H, Tsujimoto Y .......................... .
Congenital Cyst in the Tentorial Region Nakahara N, Masuzawa T, Iida K, Shimabukuro H, Yamamoto H, Iwasa H, Sato F ................................... . ... . .. .
An Autopsy Case of Cerebro-hepato-renal Syndrome of Zellweger Iwamoto H, Hayashi M, Sasaki Y, Shiihara H, Onishi S ................ .
A Long-Term Follow-Up Study of Spina Bifida Uchida T, Yokochi A, Yokochi K, Kitazumi E, Enomoto S, KodamaK . ............................................. .
Monoamine Metabolites in Cerebrospinal Fluid and Intraventricular Cerebrospinal Fluid Pressure in Childhood Hydrocephalus Ito H, Chin M, Oiwa Y, Okada K, Ito T, Miwa T ..................... .
Multicystic Encephalopathy - A Poly etiologic Condition in Early Infancy: Morphologic, Pathogenetic and Clinical Aspects Schmitt HP ............................................. .
Neonatal Neurology Histographic Analysis of Computed Tomography Scans in Term
Newborn Infants with Perinatal Asphyxia Nakada E, Tanaka M ....................................... .
Evaluation of the L VW /HW Ratio in Preterm and Term Infants with Real-Time Ultrasound Tatsuno M, Okuyama K ................................. . ... .
Pathological Studies on the Brain in Massive Aspiration Syndrome (MAS) Itoh H ................................................ .
Neuropathological Studies on the Brain of Autopsied Infants, Dying of Gastric Perforation (GP) and Necrotizing Enterocolitis (NEC) Itoh H ................................................ .
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Diagnosis of Neonatal Convulsions Using a Real-Time Ultrasound Scanner Yokota K, Hirata T . ....................................... .
Neurocutaneous Syndromes The Cystic Renal Lesions in Epileptic Patients with Tuberous Sclerosis
Watanabe Z, Ogawa S, Tsuchiya M, Murakami M, Hashimoto K, Ueda Y . ............................................... .
Abnormal Cerebral Vessels in von Recklinghausen Disease: Report of Three Cases Takenaka N, Toya S, Shiobara R, lisaka Y, Ootani M, Miyahara Y, Doumoto Y, Inoue H, Okui S, Ohira T ........................... .
Cutis Verticis Gyrata and Its Precursors in Children with Mental Retardation Tachibana H, Sugio Y ...................................... .
VIII. Intellectual, Motor and Sensory Disturbances 71 Educational Attendance of Handicapped Children in the Suburban
Area of Tokyo
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Tohjo M, Ohtsuka M, Nagase M . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 182 72 Early Signs of Spastic Diplegia: Comparative Analysis on Video
73 Clinical Features for Developing Cerebral Palsy Kanda T, Yuge M, Suzuki J, Yamori Y, Fukase H . . . . . . . . . . . . . . . . . . . . . 183
74 An Investigation of Cerebral-Palsied Children in Regular Classrooms GakuhariH, Kodama K . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 183
75 A Study on the Pathophysiology of Sudden Death in Severely-Handicapped Children Kono C, Oka E, Inoue H, Miyake S, Iyoda K, Ohtahara S . . . . . . . . . . . . . . . . 184
76 Possible Risk Factors and Signs of Mental Retardation: Comparative Study of Mentally Retarded Children and Controls Matsuishi T, Yoshimura K, Yoshida A, Yamashita F, Shiotsuki Y .......... 184
77 The Prevalence Rate and an Etiological Survey of Mental Retardation (MR) in Japanese School Children Shiotsuki Y, Matsuishi T, Yoshimura K, Yamashita F, Yano K, Tokimasa H . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185
78 A Statistical Study on Resident Deaths at Institutions for the Profoundly Retarded Nakamura H, Honda T, Uemura I, Nanba Y, Mita K, Okafa K . . . . . . . . . . . . . 185
79 On the Development of Mental Activity in the Monozygotic Twins with Early Infantile Brain Injury Hasegawa Y, Okada R, Tachi K . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 186
IX. Convulsive Disorders (1): Febrile or Non-Epileptic 80 Etiological Aspects of Epilepsy and Febrile ConVUlsions-Pregnancy
and Perinatal Factors Katafuchi Y, Aoki N, Matsuishi T, Yamashita F .................. . .. , 186
81 Follow-Up Study of Children with Simple Febrile Convulsions and Epileptiform EEG Activities without Chronic Anticonvulsant Medication Kajitani T, Kimura T, Ide K ................... - - - - . - ..... - . . .. 187
82 Clinical and Electroencephalographic Study on Siblings of Patients with Epilepsies or Febrile Convulsions Exhibiting Rolandic Discharges Nakamura M, Kajitani T, Kumanomidou Y, Kimura T . . . . . . . . . . . . . . . . . . 187
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83 Qualitative Analysis of Paroxysmal Discharges in Electroencephalograms of Febrile Convulsions and Their Prognosis Kimiya S, Seki T, Yamawaki H, Suzuki N, Maezawa M, Yamada T, Tachibana Y, Hirose M ...................................... 188
88 A Long-Term Follow-Up Study of "Cryptogenic" Status Convulsivus in Childhood A waya Y, Fukuyama Y, Iwamoto H . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 190
89 Visual Epileptic Seizures after Mild Head Injuries in Children Tamagawa K, Sasaki H, Aoki N, Shimizu H . . . . . . . . . . . . . . . . . . . . . . . .. 191
90 Headache and Convulsive Disorders: A Study on Pathophysiological Correlations Tada H, Goto M, Yonezawa M, Nomura Y, Segawa M . . . . . . . . . . . . . . . . . . 191
91 Behavioral Problems in Children with Epilepsy Matsuo M, Kurokawa T, Takaki S, Chen Y-J, Yoshida K ................ 192
92 A Floppy Child with Atonic Attacks Kuwajima K ............................................. 192
93 Risk of Seizures in Siblings of Children with Epilepsy Soda M, Nakai M, Takeshita K ................................. 193
94 Focal and Clonic Convulsions in Infancy Yokochi K, Uchida T ....................................... 193
96 A Case of Premenstrual Tension with Autonomic Seizure: Biochemical, Electroencephalographic and Endocrinological Studies Kureha Y, Numaguchi S, Obata J, Okabe T, Eto Y, Kumagai K, Maekawa K . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 194
97 Accidental Large Overdose of Sodium Valproate-A Case Report Horii Y, Ishimura K, lino S, Yoshida A, Ochi M, Yoshioka H, Kusunoki T . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 195
98 A Case of Report of Valproic Acid-Induced Pure Red Cell Aplasia Sugano T, Tominaga M, Kasubuchi Y, Imashuku S . . . . . . . . . . . . . . . . . . . . 195
XI. Convulsive Disorders (3): West or Lennox Syndrome 99 A Longitudinal Study on Early-Infantile Epileptic Encephalopathy
with Suppression-Bursts Ohtsuka Y, Yamatogi Y, Ichiba N, Terasaki T, Yoshida H, Matsuda M, Ohtahara S . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 196
101 A Study on ACTH Therapy of Infantile Spasms 2nd Report Concerning Synthetic ACTH Hashimoto K, Tamamoto A, Ozaki N, Konishi K, Takaya K ............. , 197
Contents 99
102 Suppressive Effect of ACTH on the Serum Thyroxine, Level and Its Influence on the Clinical Effectiveness in Infantile Spasms Izumi T, Fukuyama Y . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 197
103 Effects of ACTH on Sleep of Patients with West Syndrome Ogiso M, Shimohira M, Kohyama J, Niwa T, Iwakawa Y, Segawa M . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 198
104 Gamma-Globulin Therapy in Infantile Spasms Shiihara H, Michihiro N, Ogawa K, Coto K, Suzuki H, Utsumi Y, Ariizumi M, Baba K . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 198
105 A Study of Treatment of Lennox-Gastaut Syndrome Watanabe Y, Sato S, Okumura K, Aoki T . . . . . . . . . . . . . . . . . . . . . . . . .. 199
106 Effect of ACTH Therapy on Peripheral Nerve Conduction Velocity in Patients with Infantile Spasms Shinozaki K, Izumi T, Ochiai T, A waya Y, Fukuyama Y ................ 199
XII. Convulsive Disorders (4): Treatments 107 Clorazepate Therapy for Refractory Seizures in Children
109 Lidocaine in the Treatment of Status Epilepticus Sai H, Morikawa Y, Izumi H, Miyoshi K, Kimura K, Fujita H, Hino T, Mizuta R, Coto K . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 201
110 Lidocaine for the Treatment of Status Epilepticus Miyata H, Tsubota T, Kuroda E, Takemoto H, Kanazawa Y, Ogino H . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 201
111 Reevaluation of the Indication of Sodium Valproate Monotherapy in Childhood Epilepsy - Compared with Phenobarbital Monotherapy Hosaka S, Ogiso M, Iwakawa Y . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 202
112 Sodium Valproate and Clonazepam in the Treatment of Intractable Epilepsies Oki J, Tasaki T, Cho K, Yoshioka H . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 202
113 Abnormal Breath Test Results with 13C-Palmitate in Patients Treated with Valproic Acid Sakuragawa N, Suehiro M, Watanabe H . . . . . . . . . . . . . . . . . . . . . . . . . . .. 203
114 Serum Protein Binding of Phenobarbital in Childhood Tanaka J, Shimizu H, Futagi Y, Suzuki K . . . . . . . . . . . . . . . . . . . . . . . . .. 203
115 Anticonvulsant Effect of Pyridoxal Phosphate in ddY Mice Takeda H, Komatsu M, Matsui T, Nakazawa M, Kuniya S, Miyake S, Yokoyama S, Kodama S, Matsuo T ...... . . . . . . . . . . . . . . . .. 204
116 Physical and Mental Development of Infants Born to Mothers Taken Antiepileptic Drugs Nomura Y, Takebe Y, Kaneko S . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 204
117 The Serum Enzyme Activity (LAP, ALP) in Liver of Infantile Patients with AED-Correlation of Combination, Serum Concentration of AED and Serum Enzyme Activity Miyamoto S, Hisanaga M, Utsumi S, Takemura K, Kirino Y .............. 205
118 Relationship between Valproate Pharmacokinetics and Laboratory Data in Epileptic Children in the Steady-State Takebe Y, Haneda S, Kimura S, Koide N. . . . . . . . . . . . . . . . . . . . . . . . . .. 205
119 Study of Serum Immunoglobulins in Childhood Epilepsy Hibio S, Michihiro N, Ogawa K, Ohkubo 0, Utsumi Y, Ariizumi M, Baba K . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 206
100 Brain & Development, Vol 6, No 2, 1984
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Antico nvulsan ts Follow-Up Study of Plasma Ammonia Levels in Patients Treated
with Valproic Acid (VP A) Yoshimoto T, Harima Y ..................................... .
Sodium Valproate and Hyperammonemia Nishida N, Ono A, Yasuhara A, Ito N, Sugimoto T, Matsumura T, Sakane Y, Taniuchi K ............................ .
The Effects of Valproic Acid and Phenobarbital on Free Amino Acid Levels in Serum and Urine Honda T, Watanabe K, Sato Y, Tada H, Takahashi H, Kaneko K, Takahashi K, Ohtsuka C ..................................... .
Measurement of Free Phenobarbital Blood Levels Using an Amicon Centriflo Model CF 25 (Ultrafiltration Method) Fujii E, Okada K, Matsutaka K, Somqa T, Teshirogi T ................ .
Effects of Phenobarbital and Phenytoin on Lipid Peroxidation in Rats Ono J, Mimaki T, Nagaura T, Abe J, Onoe S, Tagawa T, Yabuuchi H ....... .
Effect of l~-Hydroxycholeca1ciferol on Bone Development in Epileptic Children: Follow-Up Study with a Microdensitometer Onoe S, Mimaki T, Tanaka Y, Yamaoka K, Ishida M, Seino Y, Yabuuchi H, Yamashita G ................................... .
A Study on Blood Levels of Antiepileptics before and Two Hours after Administration Nakazawa M, Kuniya S, Matsui T, Komatsu M, Yokoyama S, Kodama S, Matsuo T ....................................... .
CNS Infections A Case of Subacute Sclerosing Panencephalitis (SSPE) Treated with
Interferon Therapy for SSPE Nishimura 0, Nakagawa M, Fujiwara K, Yoshioka H, Sawada T, Kusunoki T, Kishida T ...................................... .
Inosiplex and Interferon Treatment in 2 Patients with SSPE Kataoka K, Nakagawa Y, Hojo H, Yoshioka H, Sawada T ........ . ...... .
Induction of Acute Myoclonic Encephalitis in Hamsters by SSPE Virus Sugita T, Okuni H, Imaishi H, Shiomi M, Hara T, Uchida H, Yabiku M, Ko E, Ueda S, Shiraki K ............................. .
Three Cases of Herpes Simplex Encephalitis with Reflection on the Diagnosis and Treatment Kiyohara K, Nakajima M, Nonomiya S, Hayashi M, Sekino T, Ogiso M, Arai S, Iwakawa Y .................................. .
The Early Diagnosis of Herpetic Encephalitis - Analysis of 14 Cases Hamano K, Ponsot G, Plouin P ................................ .
Measles Encephalitis in Two Immunized Children Kurashige T, Tone Y, Kuramitsu M, Kitamura I ..................... .
Subacute Encephalitis Associated with Elevated HSV-l Titer Kawano Y, Ohya T ........................................ .
A Case of SSPE after Measles Vaccination Miyake S, Katsumata N, Hayashi M, Iwamoto H ......... . ... . ... . ... .
An Autopsy Case of Subacute Sclerosing Panencephalitis with Hypogammaglo bulinemia Kyoya S, Irimichi H, Matsushima A, Kimura A, Fukase S, Koizumi F . ............................................. .
Three Cases of Congenital Cytomegalovirus Infection Ito N, Taniguchi H, Matsuzaki S, Sugimoto T, Iwase S, Matsumura T, Yasuda M .................................... .
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Contents 101
138 Rotavirus and Central Nervous System Ushijima H, Tajima T, Tagay a M, Nonaka C, Fujita S, Togo T, Hiraiwa M, Ohmi K, A be T, Nakajo M . . . . . . . . . . . . . . . . . . . . . . . 215
139 Indications for CT Examination in Purulent Meningitis - Investigation of Cases with Subdural Effusion Ishimura K, Fujiwara K, Ino S, Yoshida A, Ochi M, Yoshioka H, Kusunoki T . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 216
140 Two Cases of Severe Herpes Simplex Virus Infections Confirmed by Virus Isolation Hara T, Ito N, Sonoda N, Sugimoto T, Matsumura T, Ito T, Ohyama A . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 216
143 EEG Power Spectra and Gas Analysis of Arterial Blood during and after Hyperventilation in Moyamoya Disease in Children Nakahara S, Kawash ima K, Fujiwara J, Matsumura A , Nakata Y .......... . 218
144 Mechanism of EEG Abnormality Caused by Hyperventilation in Children with Moyamoya Disease-Hemodynamic Study by the 133Xe Inhalation Method Tagawa T, Naritomi H, Mimaki T, Abe J, Onoe S, Ono J, Yabuuchi H, Sum i K, Sawada T . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 218
145 Correlation between CT Findings and Intelligence Quotient in Pediatric Patients with Moyamoya Disease Fukumoto T, Matsushima Y, Suzuki R, Hiratsuka H, Inaba Y . . . . . . . . . . . . . 219
146 Long-Term Surgical Results of Moyamoya Disease in Childhood Yoshizawa T, Kikuchi H, Karasawa J, Nishiya M, Ihara I, Yamashita T, Nagata I, Naruo Y, !kota T, Mitsugi T, Sh ishido H, Inoue S, Hashimoto K, Minamikawa J, Miyamoto S ................... 219
148 A Study on Prognosis of Acute Hemiplegia in Childhood (AHC): Particularly with Reference to Age of Onset, Sex of Patient and Side of Lesion Honda K, Takehiro H, Miyake S, Ike Y, Kimura S, Numora Y . . . . . . . . . . . . . 220
150 Problems of Spontaneous Intracerebral Hematoma in Children -Comparison with Intracerebral Hematoma due to Cerebral Arteriovenous Malformation Nagai K, Ikeda Y, Miki T, A zuma S, Ito H, Miwa T .... . ........... .. . , 221
151 Cerebrovascular Occlusive Disease in Children Fuwa I, Kajiwara H, Yokota A, Matsukado Y, Ishizu M, Teruhisa M, Taku K . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 222
152 A Nine-Year-Old Boy.Who was Diagnosed as Cerebrovascular Disease at a Relatively Early Stage by Serial EEGs Yamada T, Seki T, Kimiya S, Maezawa M, Tachibana Y . . . . . . . . . . . . . . . .. 222
XVI. Brain Tumors, Degenerative or Etiology Unknown 153 A Case of Myoclonus Epilepsy
A Case of Childhood Multiple Sclerosis with Ring-Like Contrast Enhancement on CT Morimoto T, Sano N, Takahashi M, Habara S, Nagao H, Matsuda H, Fukui K, Beppu K, Shoda To o 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
A Case Report of Focal Nodular Myositis Associated with Various Symptoms such as Lipogranuloma Subcutanea, Anterior Mediastinitis and Nodular Masses in Lung and Brain Nobukuni Y, Tsuchiya H, Ohtani Y, Miike T, Matsuda I 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vomiting in Newborn Infants - Developmental Study Shim omura C, Ishiwa S, Nakajima K, Suzuki Y A, Ogawa Too 0 0 0 0 0 0 0 0 0 0 0 0 0
A Case of Peculiar White Matter Disease of Childhood Associated with Cortical Blindness, Cortical Deafness and Other Higher Brain Dysfunction Sawamura Y, Matsuura T, Fukushima R, Tashiro K, Takamura H 0 0 0 0 0 0 0 0 0 0
Neuropsychiatric Problems Diagnosis of Delayed Speech
Dexamethasone Suppression Test on Autistic Children Ohno Y, Hoshino Y, Yamamoto T, Watanabe K, Tachibana R, Murata S, Kaneko M, Kumashiro H 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Psychological Finding in Left-Handed Children with Epilepsy or Brain Dysfunction of Normal Intelligence Okada R, Hasegawa Y, Tachi K 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ••• •••••
Rett Syndrome - A Clinical and Pathophysiological Study Nomura Y, Segawa M, Hasegawa M, Yonezawa M, Tada H o . . . ..... . 0 •••••••• • •• •• • • 0 •• • ••••••• • ••• ••• • 0 • • ••
Electroencephalographic and Computed Cranial Tomographic Findings in Children with Clumsiness or Minimal Brain Dysfun~tion Ochiai Y, Soeda A, Kurihara M, Aso M, Yamazaki Y, Tsuzura S ..... 0 • 0 0 ••
The Correlation between Personality Disorders and Soft Neurological Signs or Hyperkinetic Syndrome in Childhood Murata S, Hoshino Y, Kaneko M, Yashima Y, Kumashiro H 0 0 ••• 0 • 0 ••• •••
Neurologic Problems in Systemic Diseases The Possibility of Acute Encephalopathy Following Administration
of Calcium Hopantenate Sugimoto T, Yasuhara A, Nishida N, Matsumura T, Sakane Y . 0 ••••• 0 0 0 •••
Two Autopsied Cases of Sudden Death Associated with Calcium Hopantenate Togashi K, Miura Y, Ishiyama S, Konno K, Suzuki H .......... 0 •• 0 ••• 0 •
Transient Multiple High Density Areas Demonstrated by Computed Tomography in a Case of Childhood Leukemia Sano N, Nagao H, Morimoto T, Takahashi M, Habara S, Matsumoto S, Kuzume K, Hayashi M, Matsuda H .... 0 0 •••••••• •••• • 0 •
Cranial Computerized Tomography (CCT) and Neuropsychological Findings in Long-Term Survivors of Acute Lymphoblastic Leukemia Hanefeld F, Harten G, Habermalz E, Henze G, Langermann H-J, Stephani U, Riehm H 0 •••• 0 0 0 0 0 0 • 0 0 • 0 0 ••• 0 0 0 • 0 0 • 0 • 0 0 0 •• 0 • •••
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170 A Boy with SLE Nephritis Showing Symptoms of Degenerative Disorder and Good Response to Methylpredonisolone Pulse Therapy lijima K, Yoshikawa N, Yokoyama S, Kodama S, Matsuo T . . . . . . . . . . . . .. 231
171 A Surgical Case of an Infant with Intracranial Hemorrhage due to Vitamin K Deficiency Tanji H, Izumi H, Shoda M, Shiro H, Tanaka H ...................... 232
XIX. Neurometabolic Disorders 172 Niemann-Pick Disease, Type A: Pathological, Histochemical,
Ultrastructural and Biochemical Studies in an Infant and a Fetus Fukuda M, Tanaka A, Iwamura C, Isshiki G, Nakamura S, Hase Y, Kobayashi Y, Matsumoto M, Kitagawa Y, Morihana Y . . . . . . . . . . . . . . . . .. 232
178 Clinical and Biochemical Studies of 25 Patients with Lactic Acidosis and Progressive Neurological Deterioration Miyabayashi S, Narisawa K, Tada K, Kobayashi Y. . . . . . . . . . . . . . . . . . . . . 235
179 Carnitine Deficiency Differentiated from Reye Syndrome Sugiyama N, Morishita H, Maki N, Ogawa Y, Wada Y, Yamamoto M, Hosoe A, Nishimura Y, Kobayashi S, Kamoshita S .................... 236
180 Cell Biological Diagnosis of Ataxia-Telangiectasia Katsura T, Ohta S, Shimada M, Shima A, Chishiro H, Kasahara Y .......... 236
181 Has Wilson Disease been Solved? Kaneko Y, Kaneko H, Kumashiro H . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 237
182 The Effects of Thyrotropin-Releasing Hormone on Monoamine Metabolism in Children with Nonprogressive Ataxic Syndrome Haraguchi H, Une Y, Hata M . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 237
183 Metabolic Changes of Catecholamines after L-DOPA Therapy in Hereditary Progressive Dystonia Shimoyamada Y, Ohmori H, Shiga S, Kawamura H, Kashii H, Kihara S .............................................. " 238
184 Plasma Catecholamine Levels at Syncope in Children Sumi K, Ito N, Nagaura T, Goto M, Yamatodani A . . . . . . . . . . . . . . . . . . .. 238
185 Effect of the Ketogenic Diet on Brain Monoamine Metabolism in Young Mice Otani K, Mimaki T, Yabuuchi H, Yamatodani A, Wada H . . . . . . . . . . . . . . .. 239
186 Report of Two Sisters with Perinatal Sudanophilic Leucodystrophy Hanawa H, Isoyama K, Kobayashi E, Ishikawa A, Yokoi S . . . . . . . . . . . . . .. 239
187 Cases of Fabry Disease in a Family Nakamura H, Maehara M, Sato C, Mizutani N, Watanabe K . . . . . . . . . . . . . . . 240
188 Two Siblings with f3-Galactosidase-Neuraminidase Deficiency Whose Clinical Symptoms Appeared during Preschool Years Takeda E, Kuroda Y, Tomita T, Kobashi H, Ito M, Watanabe T, Hashimoto T, Miyao M ....... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 240
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Enzymatic Studies of Sialidase in a Case of Severe Infantile Sialidosis with Apparently Normal Sialidase Activity Yutaka T, Okada S, Kato T, Nishigaki M, Oshima T, Yabuuchi H, Sugino M, Yamano K ...................................... .
A Case of Reye-Like Syndrome with Dicarboxylic Aciduria Woo M, Hirabayashi Y, Yoshino M, Ebina R, Nakano H, Sugimoto T ........................................... . . .
A Case of Citrullinemia been Treated as an Epilepsy Origuchi Y, Ushijima T, Sakaguchi M, Miyoshino S, Matsuda I ........... .
A Female Case of Ornithine Transcarbamylase Deficiency with Marked Abnormalities of Brain Computed Tomographic Scan Takayanagi M, Ohtake A, Ogura N, Hoshino M ...................... .
A Case of Partial Defect of Pyruvate Dehydrogenase Hayashi M, Tatsuno M, Misugi N, Iwamoto H, Koike Y, Koike M .......... .
Ultramicroscopic Findings of Lymphocytes in Congenital Metabolic Disease Ito N, Monma N, Satodate R, Ito M, Fujiwara T ..................... .
A Case of Congenital Lactic Acidosis without Enzyme Deficiency Itakura Y, Tsuchiyama A, Tamura Y, Tachi N, Tsukazaki H, Oyanagi K, Nakao T ....................................... .
A Case Study of Schizophrenia with Wilson Disease, and D-Penicillamine Treatment during Pregnancy Watanabe Y, Okumura K, Sasamoto A, Aoki T . ..................... .
A Case of Menkes Kinky Hair Syndrome with Recurrent Subdural Hematoma Hanaoka Y, Sakai A, Kurata S, Mizuno M ......................... .
Lowe Syndrome with Infantile Spasms which Showed Clinical and Electroencephalographical Improvement after Alkali Therapy -Introduction of a Newly Developed Technique for Biochemical Diagnosis of Lowe Syndrome Kimiya S, Seki T, Yamawaki H, Suzuki N, Maezawa M, Yamada T, Tachibana Y, Matsuo N ..................................... .
Two Cases of Adrenoleukodystrophy Diagnosed by Increased Serum Hexacosanoic Acid Ida H, Eto T, Maekawa K .................................... .
Spinal Cord, Peripheral Nerves & Myasthemia Four Cases of Hereditary Motor and Sensory Neuropathy in
Childhood - Light and Electron Microscopic Studies of Sural Nerve Biopsies Sugie Y, Hara M, Sugama M, Kosaka S, Shibuya T, Sugie H, Shishikura K, Ohsawa M, Suzuki H, Fukuyama Y .................... .
Three Cases of Hereditary Motor and Sensory Neuropathy in a Family (HMSN Type III) Kudo H, Terada M, Abe T, Naito H, Nihei K, Nonaka I ................ .
A Case of Congenital Hypomyelination Polyneuropathy Asoh S, Takemura T, Inoue K, Misugi N .......................... .
Sensory and Motor Neuropathy in Childhood Misugi N, Iwamoto H, Hayashi M, Miyake S ........................ .
Congenital Myasthenia Associated with Skeletal Abnormalities and Cataract in Two Sisters Okabe I, Kobayashi S, Kamoshita S ............................. .
Progressive Muscular Dystrophy Lipid Compositions of Plasma, Erythrocyte and Muscle in a Patient
and His Mother with Myotonic Dystrophy Terai K, Ito M, Oyama K, Fujiwara T, Monma N, Ito N ................ .
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206 Rehabilitation of Floppy Infants-with Special Reference to Congenital Muscular Dystrophy Including Fukuyarna Type Muscular Dystrophy Yamagata Y, Fujimoto T . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 249
207 Histopathological Study of Muscle Biopsies in Fukuyama Type Congenital Muscular Dystrophy (FCMD) - Special Reference to Calcium Staining by Kashiwa's Method Suyama A, Yabe K, Sugie Y, Sugie H, Osawa M, Suzuki H, Fukuyama Y . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 250
208 A Case of Duchenne Muscular Dystrophy with Ehlers-Danlos Syndrome Suganuma I, Sato C, Une Y, Haraguchi H, Saeki M . . . . . . . . . . . . . . . . . . .. 250
209 Delayed Muscle Fiber Type Differentiation in a Case of Congenital Myotonic Dystrophy Shikura K, Inukai K, Yoshizawa K, Nonaka I ...................... " 251
XXII. Metabolic and Other Muscle Disorders 210 The Panorama of Atypical Types of Muscular Diseases in the
San-In District of Japan Tanaka T, Takeshita K, Kasagi S, Nakashima T . . . . . . . . . . . . . . . . . . . . . .. 251
211 Modulation of Fiber Type Differentiation in Rat Soleus Muscle during Neonatal Hypothyroidism Sugie H, Sugie Y, Ohsawa M, Suzuki H, Fukuyama Y ............. . . . .. 252
212 Treatment of Polymyositis in Childhood with Particular Reference to Corticosteroid-Resistant Cases Yoshioka M, Kuroki S, Mizue H, Okuno T. . . . . . . . . . . . . . . . . . . . . . . . .. 252
215 Histochemical Study of Biopsied Muscles from Nemaline Myopathy and Congenital Fiber Type Disproportion - Behavior of Type 2B Fibers Miike T, Tamari H, Ohtani Y, Ishitsu T, Matsuda I, Miyoshino S, Une Y ................................................. 254
217 AMP Deaminase of Biopsied Muscles from Patients with Neuromuscular Disorders Nagao H, Morimoto T, Sano N, Takahashi M, Kida K, Matsuda H .......... 255
218 A Case of Congenital Myopathy with Marked Type II Muscle Fiber Hypoplasia Kuroki S, Ohkura K, Yoshioka M, Mizue H, Itagaki Y . . . . . . . . . . . . . . . . .. 255
220 Histochemical Analysis of Fiber Type Distribution and Fiber Diameters in Normal Infants Saito Y, Nonaka I . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 256
221 Successful Carnitine Treatment in Two Siblings of Lipid Storage Myopathy with Hypertrophic Cardiomyopathy Matsuishi T, Terasawa K, Hirata K, Yoshino M, Nonaka I, Sugiyama N, Ohta K, Ohtaki E, Hirose F . . . . . . . . . . . . . . . . . . . . . . . . . .. 257
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Ataxia Telangiectasia: Reduced Pyruvate Dehydrogenase Activity with Lipid Storage in Type 1 Muscle Fibers Terasawa K, Matsuishi T, Ishihara 0, Sakaguchi Y, Sugiyama N ........... .
Acute Fulminant Viral Myositis Associated with Encephalitis and Myoglobinuria Ohtani Y, Miike T, Ishitsu T, Matsuda I, Migita M, Nishihara S .. ......... .
A Case of Myositis Following Measles Infection in a Boy with Cataract and Retinal Pigmentary Degeneration Kobayashi S, Kamoshita S, Nihei K ..... .... ..... ....... ...... .. .
A Case of Probable Muscle Glycogenosis Associated with Dilated Cardiomyopathy Fujita T, Fujino 0, Hashimoto K, Hirayama T, Ueda Y, Nonaka I ........ . .
Two Females with Congenital Myopathy with Obesity, Marked Fatty Infiltration, Mild Myogenic Change and Abnormal Fiber-Type Distribution Y okochi K, Kodama K, Nonaka I ............. . .. . .......... ... .
Therapeutic Trials Clinical and Neuroendocrinological Evaluation of Thyrotropin
Releasing Hormone Tartrate in the Treatment of Psychologic Disorders of Childhood and Adolescence Kawano N, Miyao M ... . ...................... . . ... ........ .
Effectiveness of Pemoline in Attention Deficit Disorder Hara H, Ohta M, Shimizu Y, Nishihara K, Koda Y .. .. . ... ... .. . .. .... .
Therapeutic Trial of TRH-Tartrate for Consciousness Disturbance in Children Abe T, Terada M, Kudo H, Naito H, Nihei K .. ...... ..... ...... . ... .
