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Proceedings of the ASME First Global Congress on NanoEngineering for Medicine and Biology -2010- NANOENGINEERING FOR MEDICAL DIAGNOSTICS NANOENGINEERING FOR MEDICAL THERAPEUTICS AND IMAGING NANO-/MICRO-FLUIDICS FOR MEDICAL DIAGNOSTICS AND THERAPEUTICS NANOENGINEERING FOR REGENERATIVE MEDICINE MANUFACTURING AND MATERIALS FOR NANOMEDICINE MULTISCALE MODELING IN BIOLOGICAL SYSTEMS BIOLOGICAL NANOMECHANICS presented at THE ASME 2010 FIRST GLOBAL CONGRESS ON NANOENGINEERING FOR MEDICINE AND BIOLOGY FEBRUARY 7-10, 2010 HOUSTON, TEXAS, USA sponsored by ASME NANOTECHNOLOGY INSTITUTE ASME Three Park Avenue New York, N.Y. 10016
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Page 1: Proceedings of the ASME First Global Congress on ...

Proceedings of the ASME

First Global Congress on

NanoEngineering for Medicine and Biology

-2010-

NANOENGINEERING FOR MEDICAL DIAGNOSTICS

NANOENGINEERING FOR MEDICAL THERAPEUTICS AND IMAGING

NANO-/MICRO-FLUIDICS FOR MEDICAL

DIAGNOSTICS AND THERAPEUTICS

NANOENGINEERING FOR REGENERATIVE MEDICINE

MANUFACTURING AND MATERIALS FOR NANOMEDICINE

MULTISCALE MODELING IN BIOLOGICAL SYSTEMS

BIOLOGICAL NANOMECHANICS

presented at

THE ASME 2010 FIRST GLOBAL CONGRESS ON

NANOENGINEERING FOR MEDICINE AND BIOLOGY

FEBRUARY 7-10, 2010

HOUSTON, TEXAS, USA

sponsored by

ASME NANOTECHNOLOGY INSTITUTE

ASME

Three Park Avenue New York, N.Y. 10016

Page 2: Proceedings of the ASME First Global Congress on ...

CONTENTS

NANOENGINEERING FOR MEDICAL DIAGNOSTICS

NEMB2010-13014 1

Nanotechnology Based Point-of-Care Diagnostics and Therapeutics for NeurologicalDisorders

Vijay K. Varadan

NEMB2010-13017 3

Cellulose Electro-Active Paper for Biomedical ApplicationsJaehwan Kim and Yi Chen

NEMB2010-13029 5

Sensory Biofuel Cell for Self-Sustained Glucose Sensing in Healthcare Applications for

Diabetes Patients

Pratyush Rai, Jining Xie, Vijay K. Varadan, Thang Ho, and Jamie A, Hestekins

NEMB2010-13055 7

Development of Neural Probe With Wireless Power Feed

Sang H. Choi, Kyo D. Song, Yeonjoon Park, and Uhn Lee

NEMB2010-13065 11

Tuberculosis Diagnostics Using a Nanotip Sensor

Woon-Hong Yeo, Jae-Hyun Chung, and Kyong-Hoon Lee

NEMB2010-13069 13

Characterization of Biosensor Detection Process at Ultra-Low Concentration Through a

Stochastic Particle Model

Samar Shah, Yaling Liu, and Walter Hu

NEMB2010-13079 15

A Study of Bifurcation Design Used in CD-ELISA Micro-Fluidic Platform

Samuel I. En Lin

NEMB2010-13083 17

Modeling of Spin Coating Process to Control Submicron Film Thickness of Permeation LayerKama! Sarkar

NEMB2010-13124 19

Poly-Silicon Nanowire FET Chemical Sensor

Chih-Ting Lin, Che-wei Huang, and Jui-ching Wang

IMEMB2010-13126 21

Gold Nanoparticle Self Assembly on Diblock Copolymers for Application as

Biomolecular Sensors

Sarah M. Adams and Regina Ragan

NEMB2010-13128 23

Templated Assembly by Selective Removal for Size-Selective Sorting of Biological Materials

Gunjan Agarwal and Carol Livermore

ix

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NEMB2010-13142 25

Self Thermal Elimination of Nanomechanics-Based Biosensor Using a Single Free-StandingPiezoresistive Microcantilever

Yu Fu Ku, Yi-Kuang Yen, Ping-Yen Lin, and Long-Sun Huang

NEMB2010-13143 27

Ultra Sensitive Detection of Eneterovirus 71 by Modified Electrochemical Impedance

SpectroscopyShin-Hua Tseng, Dion T. Tseng, Tzu-Cheng Lee, Tsai-Mu Cheng, Jyh-Yuan Yang,

Ruo-Yu Hsieh, Chuan-Mei Tsai, and Chia-Ching Chang

NEMB2010-13148 29

Electron Transportation Behavior in Single Crystal Silicon Nanowires

Yu C. Shih, Chuin S. Chen, Chih T. Lin, and Kuang C. Wu

NEMB2010-13185 31

Fabrication of Polymeric Nano-Valve Array for Biomedical ApplicationsKuang-Fu Chang, Wen-Pin Shih, and Chuin-Shan Chen

NEMB2010-13195 35

Aptamer-Based Lab-On-Chip for Cancer Cell Isolation and Detection

Yuan Wan, Young-tae Kim, Li Na, Andrew D. Ellington, and Samir M. Iqbal

NEMB2010-13207 37

Magnetic Iron Oxide Nanotubes and Their Neuronal Applications

Jining Xie, Linfeng Chen, Vijay K. Varadan, and Malathi Srivastan

MEMB2010-13212 39

Wireless Point-of-Care Patient Monitoring System Using Zigbee and Wi-Fi Standards

Sechang Oh, Hyeokjun Kwon, Hargsoon Yoon, and Vijay K. Varadan

NEMB2010-13214 41

Alkanethiol Self-Assembled Monolayers on Microcantilever Biosensor

Chia-Ching Chou, Shu-Wei Chang, and Chuin-Shan Chen

NEMB2010-13227 43

Using Actuated Cilia to Regulate Motion of Microscopic Particles

Alexander Alexeev, Rajat Ghosh, Gavin A. Buxton, 0. Berk Usta, and Anna C. Balazs

NEMB2010-13237 45

Studying the Mechanical Sensitivity of Human Colon Cancer Cells Through a Novel

Bio-MEMS Force Sensor

Xin Tang, Tony Cappa, Theresa B. Kuhlenschmidt, Mark S. Kuhlenschmidt, and

TaherA. Saif

NEMB2010-13238 47

Nonlinear Parametric Resonance for NEMS and MEMS Biosensor ApplicationsDumitru I. Caruntu and Martin W. Knecht

NEMB2010-13256 49

Electrical Impedance Spectroscopy Microsystem as a Tool for Cancer Cell Analysis

Hyun Soo Kim, Younghak Cho, A. Bruno Frazier, Zhuo G. Chen, Dong Moon Shin, and

Arum Han

x

Page 4: Proceedings of the ASME First Global Congress on ...

NEMB2010-13268 51

Modeling and Simulations of the Motion of Bio-Inspired Micro Swimming Robots

A. F. Tabak and S.Yesilyurt

NEMB2010-13272 53

Dynamic Manipulation and Precision Localization of Nanoparticles Internal to Cells

Peter Tseng, Jack W. Judy, and Dino Di Carlo

IMEMB2010-13278 55

Platelet Nano-Forces are Similar on Fibronectin and Fibrinogen LigandsXin M. Liang and Nathan J. Sniadecki

MEMB2010-13295 57

"0NC0SENS0R" for Noninvasive High-Specificity Breast Cancer Diagnosis byCarbogen-Enhanced Neutron Femto-Oxymetry

Bogdan C. Maglich and Orhan Nalcioglu

IMEMB2010-13299 59

Design and Optimization of a Nanotip Sensor via Immersed Molecular Electrokinetic

Finite Element Method

Adrian M. Kopacz, Wing K. Liu, and Jae-Hyun Chung

NEMB2010-13302 61

Switching Between Magnetic or Oxigen Sensory Input for the MC-1 Flagellated Bacteria

to be Used for Controlling the Motion of Swarms of Bacterial Microscale Nanorobots

Sylvain Martel, Mahmood Mohammadi, and Nisryn Mokrani

NEMB2010-13307 63

Shadow Edge Lithography and Application to Nanofluidics

Woon-Hong Yeo, Dong Won Lee, Kyong-Hoon Lee, and Jae-Hyun Chung

NEMB2010-13313 65

Nanofabricated Sensing Electrodes in a Batteryless Endoluminal Sensing Telemeter for

Diagnosis of Gastroesophageal Reflux Disease (GERD)Lun-Chen Hsu, Wen-Ding Huang, Shou-Jiang Tang, Stuart Spechler, H. F. Tibbals, and

J.-C. Chiao

NEMB2010-13366 67

Added-Mass Effect in Modeling of Cilia-Based Devices for Microfiuidic SystemsJ. Kongthon, B. McKay, D. lamratanakul, Kieseok Oh, Jae-Hyun Chung, James Riley, and

Santosh Devasia

NEMB2010-13367 71

Manipulation of Clinical Materials Using AC Electrokinetics

Mandy L. Y. Sin and Pak Kin Wong

NEMB2010-13379 75

An Electrochemical Dopamine Sensor Based on a Flexible Conductive Film of Single-WallCarbon Nanotubes (SWCNT) on PET

Naser Hamdi, Vanessa Tolosa, Harold Monbouquette, Abdelaziz Rahy, and

DuckJoon Yang

xi

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IMEMB2010-13383 77

A New Platform for Profiling Active Proteases With Single-Molecule Sensitivity

M. Yusra Satoglu-Dogan, Andrey Revyakin, Sang Park, Alexandros Pertsinidis,

Christopher Brown, Steven Chu, Charles S. Craik, and Arun Majumdar

NANOENG1NEERING FOR MEDICAL THERAPEUTICS AND IMAGING

NEMB2010-13006 79

Nanocidals for Osteomyelitis ManagementYousef Haik and Shahnaz Qadri

NEMB2010 13018 83

Non-Cd Based Quantum Dots for Molecular ImagingJinhao Gao, Kai Chen, Renguo Xie, Xiaogang Peng, and Xiaoyuan Chen

NEMB2010-13022 85

Magnetic Targeting of TherapeuticsKenneth Dormer, Sunny Po, Kejian Chen, Benjamin Scherlag, Isaac Rutel, Kytai Nguyen,

Satish Kyriyavar, Brian Grady, Benjamin Shapiro, Xinsheng Gao, Xiaoping Du,

David Bourne, Kar-Ming Fung, and Richard Kopke

INJEMB2010-13050 87

Gold Nanoshell Mediated Heating of Brain Tumors

Anil M. Shetty, Jon A. Schwartz, Joshua Yung, Roger J. McNichols, Roger Price,

John D. Hazle, and R. Jason Stafford

NEMB2010-13059 89

Development of Peroxidase Biosensor for Detection of Endocrine DisruptingChemicals (EDCs)

Camille Gonzalez, Anais Vazquez, Angel Morales, Liz Diaz, Kai Griebenow, and

Carlos R. Cabrera

NEMB2010-13115 93

Enhanced Generation of Reactive Oxygen Species Using Gold Nanoparticles ConjugatedWith Protoporphyrin IX

Maung Kyaw Khaing Oo, Maria Gomez, Hongjun Wang, and Henry Du

NEMB2010-13149 95

Magnetic Resonance Imaging of Magnetic Particles for Targeted Drug DeliveryChristian Dahmen, Tim Wortmann, and Sergej Fatikow

NEMB2010-13172 97

Hyperthermic Cytotoxicity Induced by Noninvasive Radiofrequency Field Exposure After

Delivery of EGFR Family Targeted Gold NanoparticlesEvan S. Glazer, Warna D. Kaluarachchi, and Steven A. Curley

NEMB2010-13225 99

Highly Paramagnetic Tumor-Targeted Contrast AgentsAndrew Tsourkas

NEMB2010-13263 101

Chemotherapeutic Synergy Enhancement Through Micellar NanotherapeuticsElvin Blanco, Takafumi Sangai, Funda Meric-Bernstam, and Mauro Ferrari

xii

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NEMB2010-13303 105

Intracellular Trafficking of Nano-Carriers

Silvia Ferrati, Rita E. Serda, Andrew Bean, and Mauro Ferrari

NEMB2010-13314 109

Multimodality and Advanced Biomedical Imaging for Clinical and Research ApplicationsLuc Bidaut

NEMB2010-13377 111

Elucidating the Interactions of Nanomaterials With Biological SystemsWarren C. W. Chan

NANO-/MICRO-FLUIDICS FOR MEDICAL DIAGNOSTICS AND

THERAPEUTICS

NEMB2010-13007 113

Hydrodynamically Confined Microflows for Cell Adhesion Strength Measurement

Kevin V. Christ and Kevin T. Turner

NEMB2010-13030 115

Micropattem Effect on Breast Cancer Cells Behavior on Isotropically Etched Silicon

Microenvironments

Mehdi Nikkhah, Jeannine S. Strobl, Bhanu Peddi, Adedamola Omotosho, and

MasoudAgah

NEMB2010-13132 117

Development of Microfluidic Chips to Study the Effects of Shear Stress on Cell Functions

Jianbin Wang, Jinseok Heo, and Susan Z. Hua

NEMB2010-13135 119

A Microfluidic Chip for Studying Intercellular Communication via Gap Junction Channels

Cedric Bathany, Thomas Suchyna, and Susan Z Hua

NEMB2010-13183 121

Molecular Delivery Into Live Cells Using Gold Nanoparticle Arrays Fabricated by PolymerMold Guided Near-Field Photothermal Annealing

Ting-Hsiang Wu, Fan Xiao, Sheraz Kalim, Tara Tesiaa, Michael A. Teitell, and

Pei-Yu Chiou

NEMB2010-13196 123

Nanofluidic Devices for Rapid Analysis of DNA and Proteins

Jianping Fu

NEMB2010-13210 125

Enhanced Tumor Cell Separation by Surfaces Functionalized With Combinations of

Bioadhesive Proteins

Ja Hye Myung, Can A. Launiere, Khyati A. Gajjar, David T. Eddington, and

Seungpyo Hong

NEMB2010-13234 127

Fluorescence Amplification Using Biospecific Nanoparticle Conjugates as Labels in

Microfluidic Heterogeneous ImmunoassaysPeng Li, Hong Chen, Constantine Anagnostopoulos, and Mohammad Faghri

xiii

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NEMB2010-13235 129

Integrated Diagnostics for Rapid Quantitation of Biomarkers in Human Fluids

Chenlu Hou, Kelly Karns, and Amy E. Herr

NEMB2010-13236 131

Electrokinetic Transport of Molecules Through Nanochanneled Membranes

Alessandro Grattoni, Xuewu Liu, Zongxing Wang, Jaskaran Gill, Arturas Ziemys, and

Mauro Ferrari

IMEMB2010-13281 135

Nanochannels Fabrication: Filling and DNA ManipulationV. R. S. S. Mokkapati, V. Di Virgilio, J. Mollinger, J. Bastemeijer, and A. Bossche

NEMB2010-13297 139

Characterzation and Quality Control for Micro- and Nanochanneled Silicon Membranes

Jaskaran Singh Gill, Alessandro Grattoni, Arturas Ziemys, and Mauro Ferrari

NEMB2010-13300 143

A Microfluidic Assay for Metastasis Potential AnalysisSmitha M. N. Rao, Uday Tata, Victor K. Lin, Jer-Tsong Hsieh, Kytai Nguyen, and

J.-C. Chiao

NEMB2010-13317 145

Development of a Microfluidic Injection and Perfusion Device for Single Cell Study

Hsiu-hung Simor Chen, Zhiquan Shu, Lei Cheng, and Dayong Gao

NEMB2010-13328 149

A Self-Contained Microfluidic Cassette for the Detection of Nucleic Acids at the

Point-of-Care

Dafeng Chen, Xianbo Qiu, Michael Mauk, and Haim H. Bau

MEMB2010-13341 151

Microtechnologies for Neurobiology

Henry C. Zeringue

NEMB2010-13346 155

Bi-Directional AC Electroosmosis Micropump for Medical ApplicationsNazmul Islam

NEMB2010-13348 157

Analysis of Red Blood Cell Deformation in a Microfluidic Device

Giovanna Tomaiuolo, Stefano Guido, and Antonio Cassinese

IMEMB2010-13381 159

Nanomedical Applications of OptofluidicsDavid Erickson

NAIMOENGINEERING FOR REGENERATIVE MEDICINE

NEMB2010-13037 161

Effects of an Experimental Drug, Suberoylanilide Hydroxamic Acid (SAHA), on Attachment,

Spreading, and Stiffness of Human Breast Cancer Cells on Silicon Substrates

Jeannine S. Strobl, Mehdi Nikkhah, Robert Rhoades, and MasoudAgah

xiv

Page 8: Proceedings of the ASME First Global Congress on ...

NEMB2010-13114 163

Innovative Magnetic Nanoparticles Approaches for Bone and Osteochondral

Tissue EngineeringA. Russo, S. Panseri, D. Casino, T. Shelyakova, A. Tampieri, N. Bock, V. Goranov,

E. Landi, C. Dionigi, A. Riminucci, V. Dediu, and M. Marcacci

NEMB2010-13199 165

Mechanical Regulation of Stem Cell Differentiation on Geometrically ModulatedElastomeric Substrates

Jianping Fu

NEMB2010-13282 167

Coaxial Electrospinning Biopolymer With Living Cells

Qudus Hamid and Wei Sun

NEMB2010-13287 173

Nanomechanics of Electrospun Fibers for Tissue EngineeringStephen Baker, Justin Sigley, Christine Carlisle, Joel Stitzel, Joel Berry, Keith Bonin, and

Martin Guthold

NEMB2010-13290 175

The Effect of Nano Hydroxyapatite Particles on Morphology and Mechanical Properties of

Microcellular Injection Molded Polylactide/Hydroxyapatite Tissue Scaffold

Adam Kramschuster, Lih-Sheng Turng, Wan-Ju Li, Yiyan Peng, and Jun Peng

NEMB2010-13337 179

Novel Biomimetic Scaffold for Tendon/Ligament Tissue EngineeringTyler J. Allee and Wan-Ju Li

NEMB2010-13344 181

A Micro-Architectural Based Structural Model for Elastomeric Electrospun ScaffoldsAntonio D'Amore, John A. Stella, David E. Schmidt, William R. Wagner, and

Michael S. Sacks

NEMB2010-13371 183

Engineering Dense Connective Tissues via Anisotropic Nanofibrous Scaffolds With HighSacrificial Fiber Content

Brendon M. Baker, Amy M. Silverstein, and Robert L. Mauck

IMEMB2010-13372 185

Development of Nanofiber Scaffolds for Engineering an Artificial Salivary GlandMelinda Larsen, Riffard Jean-Gilles, David Soscia, Sharon Sequeira, Michael Melfi,

Anand Gadre, and James Castracane

MANUFACTURING AND MATERIALS FOR NANOMEDICINE

NEMB2010-13021 187

Protein Molecules as Natural Nano Bio Devices: Mobility AnalysisZahra Shahbazi, Horea T. Hies, and Kazem Kazerounian

xv

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NEMB2010-13025 189

Characterization of a Magnetic Microactuator for Manipulating Nanoparticles in

Gene Delivery ApplicationsEva Flick, Wenzhong Li, Jonas Norpoth, Christian Jooss, Gustav Steinhoff, and

Hans H. Gatzen

NEMB2010-13048 191

Material Study for Electrowetting-Based Multi-Microfluidics Array Printing of HighResolution Tissue Construct With Embedded Cells and Growth Factors

Chris G. Geisler, David M. Wootton, Peter I. Lelkes, Richard Fair, and Jack G. Zhou

NEMB2010-13078 195

Ink-Jet as a Manufacturing Method for Drug Delivery, Tissue Engineering, and Medical

Device ApplicationsBogdan V. Antohe and David B. Wallace

NEMB2010-13088 197

Ethical Challenges Posed by NanotechnologySubrata Saha and Stephen J. Florczyk

NEMB2010-13119 199

Preparation of Interconnected Microporous Poly(glycolic-co-lactic acid) With HighHydroxyapatite Loading

Wei Zhang, Donggang Yao, Qingwei Zhang, Jack G. Zhou, and Peter I. Lelkes

NEMB2010-13122 203

Controllable Growth of Gradient Structures for Biomedical ApplicationsWei Zhang, Donggang Yao, and Jack G. Zhou

NEMB2010-13131 207

Electrospun Recombinant Protein Polymer IManofibers as a Biomaterial

Weiguo Qiu, Yiding Huang, Joseph Cappello, and Xiaoyi Wu

NEMB2010-13141 209

Mechanical and In-Vitro Cell Compatibility Properties of Silk-Elastinlike Protein-Based

Biomaterial

Weibing Teng, Yiding Huang, Joseph Cappello, and Xiaoyi Wu

NEMB2010-13152 211

A Hybrid Nano-Bioprinting Device for Tissue EngineeringKivilcim Buyukhatipoglu, Wei Sun, and Alisa Morss Clyne

NEMB2010-13164 213

Electrostatic Self-Assembly of Functionalized Nanodiamonds and Their Binding CapacityWith Doxorubicin Drugs

Ashfaq Adnan and Wing Kam Liu

NEMB2010-13166 217

Micro-Porous PLLA Scaffolds for Orthopedic Surgical Fixation Devices

Qingwei Zhang, Wei Zhang, Donggang Yao, David M. Wotton, Peter I. Lelkes, and

Jack G. Zhou

xvi

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NEMB2010-13179 219

Photothermal Therapy of Glioma in a Mouse Model With Near-Infrared Excited Nanoshells

Emily S. Day, Linna Zhang, Nastassja A. Lewinski, Patrick A. Thompson,Rebekah A. Drezek, Susan M. Blaney, and Jennifer L. West

NEMB2010-13180 221

Cancer Imaging and Thermal Therapy Facilitated by Nanoparticles and MultiphotonMicroscopy

Emily S. Day, Lissett R. Bickford, Rebekah A. Drezek, and Jennifer L. West

NEMB2010-13181 223

Gas-Phase Production of Multifunctional Composite Nanoparticles by Photoinduced

Chemical Vapor DepositionAdam Boies, Pingyan Lei, Jeff Roberts, and Steven Girshick

NEMB2010-13209 225

Simulation of the Diffusion of Doxorubicin (DOX) in Polymer Pores for a Multiscale

Nanodiamond Based Drug Delivery SystemPaul D. Arendt, Wei Chen, and Wing Kam Liu

NEMB2010-13242 227

Unnatural Amino Acids Modified Clays for Design of Scaffolds for Bone Tissue EngineeringKalpana S. Katti, Dinesh R. Katti, and Avinash H. Ambre

NEMB2010-13258 229

Factors Affecting the Assembly of Carbon Nanostructures With Cells and EnzymesSonal Mazumder, Suvojit Ghosh, Joseph O. Falkinham, III, and Ishwar K. Puri

IMEMB2010-13266 233

Structure and Surface Properties of Nanodiamonds: A First-Principles Multiscale ApproachAditi Datta, Yao Fu, Mesut Kirca, and Albert To

IMEMB2010-13273 237

Multiscale Modeling and Simulation for Nanodiamond-Based Therapeutic DeliveryWing Kam Liu and Ashfaq Adnan

NEMB2010-13326 239

Fabrication of Single-Crystal Nanospherical Hydroxyapatite Powder for Biomedical

Applications

Peyman Honarmandi

NEMB2010-13336 241

PLLA-Nanodiamond Composites and Their Application in Bone Tissue EngineeringQingwei Zhang, loannis Neitzel, Vadym N. Mochalin, Isabel Knoke, David M. Wotton,

Yury Gogotsi, Peter I. Lelkes, and Jack G. Zhou

IMEMB2010-13339 243

Functional Nanodiamond Internalization Mechanisms and Kinetics

Robert Lam, Xueqing Zhang, Mark Chen, and Dean Ho

NEMB2010-13340 245

A Platform Approach to Gene Delivery Via Surface Modified Nanodiamonds

Xue-Qing Zhang, Mark Chen, Robert Lam, Xiaoyang Xu, Eiji Osawa, and Dean Ho

xvii

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IMEMB2010-13354 247

Metals, Semiconductors, and Alloy Nanowires on DNA Scaffolds: Synthesis and Device

ApplicationsSubrata Kundu and Hong Liang

NEMB2010-13357 249

Ordered Au Nanodisk and Nanohole Arrays: Fabrications and ApplicationsYue Bing Zheng, Jinjie Shi, Bala Krishna Juluri, and Tony Jun Huang

MULTISCALE MODELING IN BIOLOGICAL SYSTEMS

NEMB2010-13012 253

Multiscale Modeling of Blood Flow in Cerebral Malaria

Dmitry A. Fedosov, Bruce Caswell, and George Em Karniadakis

NEMB2010-13013 255

E-cadherin N-glycosylation Modulates the Strength of Adherens Junctions

Sarah J. Shareef, Mihai Nita-Lazar, and Maria A. Kukuruzinska

IMEMB2010-13034 257

Pumping Characteristics of the Lymphatic SystemJames E. Moore, Jr.

NEMB2010-13058 259

On Structure and Elastic Fields of Random Fiber Networks

Hamed Hatami-Marbini and Catalin R. Picu

NEMB2010-13066 261

Multiscale Modeling of Cortical Bone

Elham Hamed, Yikhan Lee, and Iwona M. Jasiuk

NEMB2010-13070 263

Modeling of Drug and Drug-Encapsulated Nanoparticle Transport in Patient-SpecificCoronary Artery Walls to Treat Vulnerable Plaques

Shaolie Hossain, Syed Hossainy, Yuri Bazilevs, Victor M. Calo, and Thomas J. R. Hughes

NEMB2010-13073 265

Influence of Nanoparticle Design on Binding Efficiency

Yaling Liu, Samar Shah, Walter Hu, and Jinming Gao

NEMB2010-13074 267

Modeling DNA Translocation Kinetics in Nanopores With SelectivityAbhijit Ramachandran, Qingjiang Guo, Samir Iqbal, and Yaling Liu

NEMB2010-13090 269

Multiscale Elastic Network Model for Macromolecular Machines

Moon K. Kim, Byeongsoo Lim, and Wing Kam Liu

IMEMB2010-13102 271

Hierarchical Structure Controls IManomechanical Properties of Vimentin Intermediate

Filaments

Markus J. Buehler and Qin Zhao

xviii

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NEMB201013106 273

Transition Pathway for the Minus-End Directed Movement of Kinesin-14 NCD

Sirish Kaushik Lakkaraju and Wonmuk Hwang

NEMB2010-13108 275

Structure of Water Hydration Around CollagenKrishnakumar M. Ravikumar and Wonmuk Hwang

NEMB2010-13121 277

Investigation of RBC Remodeling With a Multiscale Model

Qiang Zhu, Zhangli Peng, and Robert J. Asaro

NEMB2010-13123 279

Divide-and-Conquer Based Adaptive Coarse Grained Simulation of RNA

Mohammad Poursina, Kishor Bhalerao, and Kurt Anderson

NEMB2010-13125 283

Fibrin Networks Sustain Large Extensions Due to Unfolding Proteins

Prashant K. Purohit

NEMB2010-13155 285

Swimming Microorganisms in Complex Media

Henry C. Fu, Charles W. Wolgemuth, Vivek Shenoy, and Thomas Powers

NEMB2010-13157 287

Atomistic to Continuum Modeling of DNA Molecules

C. H, Lee, H, Teng, and J. S. Chen

NEMB2010-13160 - 289

Molecular and Mesoscale Mechanisms of Osteogenesis Imperfecta Disease

Sebastien Uzel and Markus J. Buehler

NEMB2010-13165 291

Rho-GTPase Regulation by GEFs, GAPs and GDIs in Cell MigrationXavier Diego, Eugenio Onate, and Wing Kam Liu

NEMB2010-13170 295

Multiscale Modeling of Protein Crystals: Application to Tetragonal LysozymeAmir Reza Zamiri and Suvranu De

NEMB2010-13171 297

Modeling the Effect of Hemodynamics on Cardiac Growth During Embryonic DevelopmentSandra Rugonyi and Kent Thornburg

NEMB2010-13175 299

The Contribution of Proteoglycans to the Mechanical Properties of the Corneal Stroma

Hamed Hatami-Marbini and Peter M. Pinsky

NEMB2010-13216 301

Silica Nanochannel Surface Effect on Monosaccharide TransportArturas Ziemys, Alessandro Grattoni, Jaskaran Gill, and Mauro Ferrari

xix

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NEMB2010-13244... 305

Regulating Motion of Magnetic Capsules in Microfluidic SystemsHassan Masoud, Alexander Kilimnik, and Alexander Alexeev

NEMB2010-13253 307

A Hybrid Model for Nanoparticle Targeted Delivery in Blood Flow

Yaling Liu, Jifu Tan, and Samar Shah

NEMB2010-13257 309

Flow Structures in Three-Dimensional Fish-Like Swimming

Xing Zhang, Shizhao Wang, and Guowei He

NEMB2010-13267 311

Numerical Simulation of Arbitrarily Shaped Particle Transport in an Incompressible Flow

M. D. de Tullio, G. Adrian!, P. De Palma, G. Pascazio, and P. Decuzzi

NEMB2010-13269 313

Modeling of Endothelial Cell Adhesion Dynamics Modulated by Molecular Engineering

Adrian M. Kopacz, Brandon J. Tefft, Shu Q. Liu, and Wing K. Liu

NEMB2010-13312 315

Finite Element Framework for Mechanics and Dynamics of Supramolecular Protein

Assemblies

Do-Nyun Kim, Reza Sharifi Sedeh, Cong Tri Nguyen, and Mark Bathe

NEMB2010-13320 317

Mechanical Characterization of Biological Tissue: Finite Element ModelingYue Xuan and Wei Tong

NEMB2010-13347 319

Microstrucutre-Based Modeling of Ti-6AI-4V Lattice Structures and Trabecular Bone

Hang Yao and Wei Tong

NEMB2010-13352 321

Micro-Mechanical Characterisation of Human Cortical Bone

Julien Jonvaux, Elisa Budyn, and Thierry Hoc

BIOLOGICAL NANOMECHANICS

NEMB2010-13010 325

Modeling Nanomechanical Strains in Healthy and Diseased Single-Cells Due to Applied

Fluidic Stresses

Zachary D. Wilson and Sean S. Kohles

NEMB2010-13027 329

Simultaneous Measurements of Diffusion Coefficient on Cell Membrane by Fluorescence

Photobleaching and Single Quantum Dot Tracking TechniquesDonghee Lee, Jeonghoon Lee, Choonho Park, and Jung Kyung Kim

NEMB2010-13032 331

Quantifying the Nanomechanical Properties of Bacillus Anthracis and Implications for

Spore KillingTerri A. Camesano, Paola A. Pinzdn-Arango, and Ramanathan Nagarajan

xx

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NEMB2010-13039 333

Nanomechanochemical Delivery of Nanoparticles for Nanomechanics Inside Living Cells

Kyungsuk Yum, Sungsoo Na, Yang Xiang, Ning Wang, and Min-Feng Yu

NEMB2010-13057 335

Inkjet Printing of High-Density Bacterial Arrays for Biosensor Applications

Myoung-Ock Cho, Sunghee Yoon, and Jung Kyung Kim

NEMB2010-13077 337

Nano-Structure of Collagen Fibrils in Human Intervertebral Discs and Its Correlation

With the Tissue Mechanics

Darwesh M. K. Aladin, Kenneth M. C. Cheung, Alfonso H. W. Ngan, Danny Chan,

Victor Y. L. Leung, Chwee Teck Urn, Keith D. K. Luk, and William W. Lu

NEMB2010-13103 339

Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate

Filaments

Markus J. Buehler and Jeremie Bertaud

NEMB2010-13154 341

Growth Responses of Swarming and Gliding Bacteria on Substrates With Different

Levels of Stiffness

Eun-Jung Park, Myoung-Ock Cho, and Jung Kyung Kim

NEMB2010-13156 343

Computational Investigation of Dynamic Properties of Actin Networks With

Crosslinking Proteins

Taeyoon Kim, Wonmuk Hwang, and Roger D. Kamm

NEMB2010-13177 345

Multifaceted Nano- and Micropatterned Surfaces for Cell Adhesion ManipulationJohn H. Slater, Jordan S. Miller, Shann S. Yu, and Jennifer L. West

NEMB2010-13198 347

DNA Damage by NanoparticlesThomas Prevenslik

NEMB2010-13211 349

DNA: Not Merely the Secret of Life

Nadrian C. Seeman

NEMB2010-13233 351

Knockdown of SHP-1 Enhances Endothelial Cell Retention for Vascular RegenerationBrandon J. Tefft, Adrian M. Kopacz, Wing Kam Liu, and Shu Q. Liu

IMEMB2010-13239 353

Mechanically Based Simulations of the Dynamics of Growing Cell Clusters

Ignacio Romero and Juan J. Arribas

NEMB2010-13271 355

Random Sampling Monte-Carlo Approach to Studying Entropic Elasticity Properties of

Cell Proteins and LipidsEduard Karpov

xxi

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NEMB2010-13277 357

Molecular Dynamics Study of Nanobio Membranes

Negin Maftouni, M. Amininasab, and Farshad Kowsari

NEMB2010-13311 359

A Theoretical Analysis for the Effect of Substrate Elasticity on Cellular Adhesion

Alireza Sarvestani

NEMB2010-13321 361

Kinetics of Membrane Spreading on Compliant Bio-Adhesive Substrates

Alireza Sarvestani

POSTER SESSION

IMEMB2010-13075 363

Modeling Targeted Drug Delivery in a Vascular Network

Yaling Liu, Kytai Nguyen, Manohara Mariyappa, Samar Shah, and Jifu Tan

NEMB2010-13093 365

Nanoscale Analysis of the Effect of Pathogenic Mutations on Polycystin-1

Liang Ma, Meixiang Xu, and Andres F. Oberhauser

NEMB2010-13298 367

Electrospun Polycaprolactone/Nanodiamond Composite Scaffolds for Bone Tissue

EngineeringAmanee D. Salaam and Derrick Dean

Author Index 371

xxii


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