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PRODUCT - Humco€¦ · however, pricing and specifications are subject to change without notice....

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PRODUCT CATALOG COMPOUNDING www.Humco.com +1 (855) 925-4736
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Page 1: PRODUCT - Humco€¦ · however, pricing and specifications are subject to change without notice. Please contact your Account Manager or visit the website for updated information.

PRODUCTC ATA L O GC O M P O U N D I N G

www.Humco.com +1 (855) 925-4736

Page 2: PRODUCT - Humco€¦ · however, pricing and specifications are subject to change without notice. Please contact your Account Manager or visit the website for updated information.

HUMCO GLOBAL HEADQUARTERS201 W. 5th St, Floor 12Austin, TX 78701

PHONE & FAX+1 (855) 925-4736 - toll free+1 (512) 474-7400+1 (512) 474-7414 - fax

[email protected]

ONLINE ORDERINGwww.Humco.com

PROFESSIONAL SERVICE HOURSMonday-Friday, 8:30 AM - 5:30 PM Central Standard Time

PHARMACEUTICAL RESOURCECENTER & CUSTOMER SERVICE

+1 (855) 925-4736 - toll free+1 (512) 474-7400

• Formulation questions• Stability testing & BUD data• Penetration studies• Request a sample• Certificate of Analysis

REMIT PAYMENTS TO7400 Alumax DriveTexarkana, TX 75501

SHIPPING - FREEUPS Ground Service is free for DTP (Direct-to-Pharmacy) accounts on orders of more than $100 and weighing less than 200 pounds in the lower 48 states. For orders less than $100, shipping charges based on weight will apply.

Excludes hazardous materials, oversized (larger than 84”) items, drop shipped, and any items requiring special handling.

ALASKA & HAWAIIUS published rate

OUTSIDE THE U.S.Please call your International Representa-tive for current shipping charges

HAZARDOUS MATERIALSPer package fee of $32-$45 in addition to air or ground shipping charge.

BACK ORDERSWe will notify you if any items are unavailable to ship. All back orders will be shipped free, UPS 3 day service, unless otherwise specified.

SDS & BUD STUDIESAvailable online at www.Humco.com

2 HUMCO   •    +1 (855) 925-4736   •    WWW.HUMCO.COM

Page 3: PRODUCT - Humco€¦ · however, pricing and specifications are subject to change without notice. Please contact your Account Manager or visit the website for updated information.

WWW.HUMCO.COM • +1 (855) 925-4736  • HUMCO 3

CONTENTSABOUT HUMCOHUMCO COMPOUNDINGPRODUCT LISTACTIVE PHARMACEUTICAL INGREDIENTS & CHEMICALSSTABILITY STUDIESTOPICAL/TRANSDERMAL BASESCOMPOUNDING ENHANCERCOMPOUNDING CONCENTRATESCOMPOUNDING DILUTIONSORAL VEHICLES MISCELLANEOUS INGREDIENTS HUMCO NATURAL THERAPIES

456

8 12 14 41 42 43 44 47 48

Page 4: PRODUCT - Humco€¦ · however, pricing and specifications are subject to change without notice. Please contact your Account Manager or visit the website for updated information.

4 HUMCO   •    +1 (855) 925-4736   •    WWW.HUMCO.COM

Humco, founded in 1872, is a diversified global pharmaceutical company. Humco is focused on developing, manufacturing and commercializing innovative pharmaceuticals and high-quality over-the- counter (OTC) medicines for patients around the world.

With headquarters in Austin, TX, Humco serves over 45,000 pharmacies through its Pharmaceutical Segment and its Consumer OTC Products franchise. The Company is anchored by its lead-ing non-sterile compounding deliv-ery vehicles, including topical and transdermal creams, syrups and suspensions. Humco also serves consumers through its established and diverse Consumer OTC Prod-ucts business of over 160 items with product placement in all major drug, food, and mass-market retail chains, along with independent, locally owned pharmacies.

Humco’s leading team of professionals have strong exper-tise ranging from product develop-ment to commercialization in the Company’s state-of-the-art FDA registered, cGMP compliant facili-ties.

With a presence in approximately 20 countries, Humco is committed to working with pharmacists, physicians, health- care providers and patients to deliver innovative and meaningful treaments that help people around the world live longer, healthier lives.

ABOUT HUMCO

Page 5: PRODUCT - Humco€¦ · however, pricing and specifications are subject to change without notice. Please contact your Account Manager or visit the website for updated information.

WWW.HUMCO.COM • +1 (855) 925-4736  • HUMCO 5

HUMCO COMPOUNDING

OUR APPROACH:

•We can be counted on

•We get the job done

•We take responsibility

•We find a better way

•We succeed as a team

Humco proudly manufactures and distributes a diversified line of phar-maceutical products. We focus on developing products that offer dynamic solutions and help to fulfill unmet pa-tient and pharmacist needs.

Humco has a vast portfolio ofpharmaceuticals thataid in imperativesolutions across several key therap-eutic categoriesincluding:

• Pain Management• Infectious Disease• Hormone Replacement Therapy• Wound Care• Dermatology and Aesthetics Humco has established a leading rep-utation for developing, manufacturing, and commercializing a diversified line of non-sterile topical and oralpharmaceutical compounding delivery vehicles. Our patented compounding products range from ready-to-use

topical creams and gels to oralsyrups and suspensions. Our prod-ucts are designed to provide an opti-mal delivery system for a variety offormulations based on the desired route of administration and therapeu-tic intent. Humco’s delivery vehicles are tailored to meet pharmacist’s non-sterile compounding needs while reducing the compounding preparation time and improving therapeutic outcome for patients.

In addition to our delivery vehicles, Humco offers an extensive selection of Active Pharmaceutical Ingredients (APIs) that are conveniently pack-aged in a variety of sizes to effectively accommodate the needs of pharma-cists, hospitals, and pharmaceutical companies.

Page 6: PRODUCT - Humco€¦ · however, pricing and specifications are subject to change without notice. Please contact your Account Manager or visit the website for updated information.

6 HUMCO   •    +1 (855) 925-4736   •    WWW.HUMCO.COM

TOPICAL & TRANSDERMAL BASESSANAREADVANCED™SCAR THERAPY BASE

Item No. Size Price 0112-56 500 g Call for Price0112-59 2.5 kg Call for Price0112-31 5.8 kg Call for Price

PLO20 FLOWABLE™ PRE-MADE FLOWABLE PLO BASE

Item No. Size Price 0135-56 500 g $65.00

PLO20 NON-FLOWABLE™ PRE-MADE PLO BASE

Item No. Size Price 6008-56 500 g $50.006008-57 4.5 kg $365.00

UNIVERSAL WATER GEL™VERSATILE TOPICAL BASE

Item No. Size Price 6017-56 500 g $21.006017-57 4.5 kg $165.00

COMPOUNDING ENHANCEREMULSION CONCENTRATE™VISCOSITY ENHANCER

Item No. Size Price 6016-94 4 oz $35.006016-98 8 oz $57.00

*Prices are current at time of printing (May 15, 2019); however, pricing and specifications are subject to change without notice. Please contact your Account Manager or visit the website for updated information.

BULK PRICING AVAILABLEContact us for pricing on bulk quantities

+1 (855) 925-4736

Our compounding bases and vehicles are ready-made with wetting agents already incorporated into the base. Most formulations will not require any additional wetting or milling, greatly reducing the compounding preparation time.

ANHYDROUS BASE™VERSATILE TOPICAL BASE

Item No. Size Price 6013-56 500 g $50.00

GENEDERM™ DERMATOLOGICAL BASE FOR ANTI-AGING

Item No. Size Price 6026-56 500 g $186.00

HRT BOTANICAL™CERTIFIED HYPOALLERGENIC HRT BASE

Item No. Size Price 6001-56 500 g $38.006001-57 4.5 kg $240.00

HRT HEAVY™ CERTIFIED HYPOALLERGENIC HRT BASE

Item No. Size Price 6002-56 500 g $38.006002-57 4.5 kg $240.006002-58 18 kg $660.00

LIPOSOMAL HEAVY™MOISTURIZING LIPOSOMAL BASE

Item No. Size Price 6004-56 500 g $50.006004-57 4.5 kg $365.006004-58 18 kg $1310.00

LIPOSOMAL REGULAR™MOISTURIZING LIPOSOMAL BASE

Item No. Size Price 6003-56 500 g $50.006003-57 4.5 kg $365.006003-58 18 kg $1310.00

MULTIBASE™ VERSATILE OIL-IN-WATER BASE

Item No. Size Price 6015-56 500 g $45.006015-57 4.5 kg $380.00

PENCREAM™VANISHING OIL-IN-WATER BASE

Item No. Size Price 6010-56 500 g $25.006010-57 4.5 kg $250.006010-58 18 kg $1000.00

RECURA™ANTIFUNGAL BASE

Item No. Size Price 6020-56 500 g $250.006020-59 2.5 kg $750.00

SALTSTABLE LO™ TRANSDERMAL PAIN MANAGEMENT BASE

Item No. Size Price 6009-56 500 g $70.006009-57 4.5 kg $450.006009-58 18 kg $1600.00

SALTSTABLE LSADVANCED™TRANSDERMAL PAIN MANAGEMENT BASE

Item No. Size Price 6021-56 500 g $90.006021-57 4.5 kg $525.006021-58 18 kg $1890.00

LAVARE™WATER-WASHABLE WOUND CARE BASE

Item No. Size Price 7001-56 500 g Call for Price7001-59 2.5 kg Call for Price

Page 7: PRODUCT - Humco€¦ · however, pricing and specifications are subject to change without notice. Please contact your Account Manager or visit the website for updated information.

ESTRADIOL HEMI- HYDRATE, USP 10% PRE-MIXED HORMONE IN A BASE

Item No. Size Price 6540-62 100 g Call for Price 6540-56 500 g Call for Price

ESTRIOL, USP 10% PRE-MIXED HORMONE IN A BASE

Item No. Size Price 6550-19 25 g Call for Price 6550-62 100 g Call for Price

PROGESTERONE, USP 40% PRE-MIXED HORMONE IN A BASE

Item No. Size Price 6500-62 100 g Call for Price6500-56 500 g Call for Price

TESTOSTERONE, USP 20% CIII * PRE-MIXED HORMONE IN A BASE

Item No. Size Price 6520-62 100 g Call for Price6520-56 500 g Call for Price

LEVOTHYROXINE SODIUM, USP (T3)1:1000 DILUTION

Item No. Size Price 6570-19 25 g $80.006570-62 100 g $285.006570-56 500 g $1040.00

LIOTHYRONINE SODIUM, USP (T3)1:1000 DILUTION

Item No. Size Price 6560-19 25 g $90.006560-62 100 g $345.006560-56 500 g $1290.00

FLAVOR SWEET™SYRUP VEHICLE

Item No. Size Price 0090-16 16 oz $12.250090-28 1 gal $80.00

FLAVOR SWEET-SF™SUGAR-FREE SYRUP VEHICLE

Item No. Size Price 0094-16 16 oz $12.250094-28 1 gal $80.00

FLAVOR PLUS™SUSPENDING VEHICLE

Item No. Size Price 0091-16 16 oz $12.250091-28 1 gal $80.00

FLAVOR BLEND™ALL-IN-ONE SYRUP/SUSPENDING VEHICLE

Item No. Size Price 0089-16 16 oz $12.250089-28 1 gal $80.00

VERSA FREE™DYE-FREE, CHEMICAL-FREE, AND SUGAR-FREE SYRUP VEHICLE

Item No. Size Price 0125-16 16 oz $16.500125-28 1 gal $85.00

VERSA PLUS™DYE-FREE, CHEMICAL-FREE, AND SUGAR-FREE SUSPENDING VEHICLE

Item No. Size Price 0126-16 16 oz $16.500126-28 1 gal $85.00

FIXED OIL SUSPENSIONSUSPENDING VEHICLE

Item No. Size Price 2080-16 16 oz $48.002080-28 1 gal $312.00

CHERRY SYRUPSYRUP VEHICLE

Item No. Size Price 2662-16 16 oz $12.002662-28 1 gal $65.00

RASPBERRY SYRUPSYRUP VEHICLE

Item No. Size Price 2664-16 16 oz $14.25

SIMPLE SYRUPSYRUP VEHICLE

Item No. Size Price 2661-16 16 oz $12.002661-28 1 gal $65.002661-75 5 gal $180.00

SORBITOL SOLUTION70%, USP SYRUP VEHICLE

Item No. Size Price 3913-16 16 oz $6.50

SYRPALTA (RED) SYRUP VEHICLE

Item No. Size Price 3920-16 16 oz $16.00

SYRPALTA (WITHOUT COLOR)SYRUP VEHICLE

Item No. Size Price 3927-16 16 oz $16.00

WWW.HUMCO.COM • +1 (855) 925-4736  • HUMCO 7

ORAL VEHICLESCOMPOUNDING CONCENTRATES

COMPOUNDING DILUTIONS

* To purchase this item you must have a DEA license on file

Page 8: PRODUCT - Humco€¦ · however, pricing and specifications are subject to change without notice. Please contact your Account Manager or visit the website for updated information.

7-KETO DHEA Item No. Size 810719805 25 g 810762805 100 g

ACYCLOVIR, USP Item No. Size 809719805 25 g 809762805 100 g

ALPROSTADIL, USP Item No. Size 810276805 10 mg 810282805 100 mg810283805 500 mg

AMANTADINE HYDROCHLORIDE, USP

Item No. Size 805862001 100 g 805843001 1 kg

AMITRIPTYLINE HYDROCHLORIDE, USP

Item No. Size 804862805 100 g 804843805 1 kg

AMLODIPINE BESYLATE, USP

Item No. Size 809219805 25 g 809262005 100 g

BACLOFEN, USP Item No. Size 803262805 100 g 803243805 1 kg

BENZOCAINE, USP Item No. Size 804962805 100 g 804943805 1 kg

BUDESONIDE, USP (MICRONIZED)

Item No. Size 813837805 1 g 813835805 5 g

BUPIVACAINE HYDROCHLO-RIDE, USP (MONOHYDRATE)

Item No. Size 805062805 100 g 805043805 1 kg

BUTYLATED HYDROXYTOLUENE, NF

Item No. Size 813435805 5 g 813462805 100 g

CHOLESTYRAMINE RESIN, USP

Item No. Size 813919805 25 g 813962805 100 g813956805 500 g

CIMETIDINE, USP Item No. Size 807962805 100 g 807943805 1 kg

CLINDAMYCIN HYDROCHLORIDE, USP

Item No. Size 810419805 25 g 810462805 100 g

CLONIDINE HYDROCHLORIDE, USP

Item No. Size 813235805 5 g 813219805 25 g813262805 100 g

ACTIVE PHARMACEUTICAL INGREDIENTS & CHEMICALS

8 HUMCO   •    +1 (855) 925-4736   •    WWW.HUMCO.COM

COENZYME Q10, USP Item No. Size 811119805 25 g 811162805 100 g811143805 1 kg

CYANOCOBALAMIN, USP Item No. Size 814035805 5 g 814019805 25 g

CYCLOBENZAPRINE HYDROCHLORIDE, USP

Item No. Size 805162805 100 g 805143805 1 kg

CYCLOSPORINE A, USP Item No. Size 810835805 5 g 810819805 25 g810862805 100 g

DEXAMETHASONE SODIUM PHOSPHATE, USP

Item No. Size 814135805 5 g 814119805 25 g814162805 100 g

DEXAMETHASONE, USP Item No. Size 814235805 5 g 814219805 25 g

DHEA (MICRONIZED) (PRASTERONE)

Item No. Size 806919805 25 g 806962805 100 g806943805 1 kg

DIAZEPAM, USP CIV * Item No. Size 814319805 25 g 814362805 100 g

DICLOFENAC SODIUM, USP Item No. Size 805262805 100 g 805243805 1 kg

DILTIAZEM HYDROCHLORIDE, USP

Item No. Size 811035805 5 g 811019805 25 g811062805 100 g

DIPHENHYDRAMINE HYDROCHLORIDE, USP

Item No. Size 810919805 25 g 810962805 100 g810956805 500 g

DOXEPIN HYDROCHLORIDE, USP

Item No. Size 813519805 25 g 813562805 100 g813556805 500 g

DOXYCYCLINE HYCLATE, USP

Item No. Size 805962805 100 g 805943805 1 kg805952805 25 kg

DULOXETINE HYDROCHLORIDE, USP

Item No. Size 810635805 5 g 810619805 25 g

ESTRADIOL HEMIHYDRATE, USP (MICRONIZED)

Item No. Size 806519805 25 g 806562805 100 g

* To purchase this item you must have a DEA license on file

Product Ordering Information Product Ordering Information

Page 9: PRODUCT - Humco€¦ · however, pricing and specifications are subject to change without notice. Please contact your Account Manager or visit the website for updated information.

WWW.HUMCO.COM • +1 (855) 925-4736  • HUMCO 9

Humco is committed to adhering to the highest quality standards to ensure that our products are consistently valued as the best option for patients and pharmacists.

ESTRIOL, USP (MICRONIZED) Item No. Size 806619805 25 g 806662805 100 g

ESTRONE, USP Item No. Size 806719805 25 g 806762805 100 g

FLUCONAZOLE, USP Item No. Size 803619805 25 g 803662805 100 g803643805 1 kg

FLUOROURACIL (5), USP Item No. Size 808019805 25 g 808062805 100 g

FLUOXETINE HYDROCHLORIDE, USP

Item No. Size 814419805 25 g 814462805 100 g814456805 500 g

FLURBIPROFEN, USP Item No. Size 805362805 100 g 805343805 1 kg

FLUTICASONE PROPIONATE, USP (MICRONIZED)

Item No. Size 805435805 5 g 805419805 25 g

GABAPENTIN, USP Item No. Size 805562805 100 g 805543805 1 kg

GREEN TEA EXTRACT Item No. Size 814543805 1 kg

HALOPERIDOL, USP Item No. Size 809637805 1 g 809635805 5 g

HUMAN CHORIONIC GONADOTROPIN (HCG)

Item No. Size 809467805 5 MU

HYDROCORTISONE, USP (MICRONIZED)

Item No. Size 814619805 25 g 814662805 100 g814656805 500 g

HYDROQUINONE, USP Item No. Size 812719805 25 g 812762805 100 g812756805 500 g

IBUPROFEN, USP Item No. Size 803862805 100 g 803843805 1 kg

INDOMETHACIN, USP Item No. Size 811219805 25 g 811262805 100 g

ITRACONAZOLE, USP (MICRONIZED)

Item No. Size 811319805 25 g 811362805 100 g811356805 500 g

KETAMINE HYDROCHLORIDE, USP CIII *

Item No. Size 807062805 100 g 807043805 1 kg

KETOCONAZOLE, USP Item No. Size 803919805 25 g 803962805 100 g803956805 500 g

KETOPROFEN, USP Item No. Size 805662805 100 g 805643805 1 kg

KOJIC ACID Item No. Size 808619805 25 g 808662805 100 g

LANSOPRAZOLE, USP Item No. Size 809935805 5 g 809919805 25 g

LEVETIRACETAM, USP Item No. Size 816062805 100 g 816056805 500 g816043805 1 kg

LEVOTHYROXINE SODIUM, USP

Item No. Size 807337805 1 g 807335805 5 g

LIDOCAINE HYDROCHLORIDE, USP

Item No. Size 804062805 100 g 804043805 1 kg

LIDOCAINE, USP Item No. Size 813362805 100 g 813356805 500 g813343805 1 kg

LIOTHYRONINE SODIUM, USP Item No. Size 807237805 1 g 807235805 5 g

LORAZEPAM, USP CIV * Item No. Size 816135805 5 g 816119805 25 g816162805 100 g

MELOXICAM, USP Item No. Size 815462805 100 g 815456805 500 g815443805 1 kg

METHIMAZOLE, USP Item No. Size 807462805 100 g 807443805 1 kg

METHYLCOBALAMIN, JP Item No. Size 813637805 1 g 813635805 5 g813619805 25 g

Ordering Information Ordering Information Product Product

Page 10: PRODUCT - Humco€¦ · however, pricing and specifications are subject to change without notice. Please contact your Account Manager or visit the website for updated information.

ACTIVE PHARMACEUTICAL INGREDIENTS & CHEMICALS

10 HUMCO   •    +1 (855) 925-4736   •    WWW.HUMCO.COM

* To purchase this item you must have a DEA license on file

Product Product Ordering InformationOrdering InformationMETRONIDAZOLE BENZOATE, USP

Item No. Size 811462805 100 g 811456805 500 g811443805 1 kg

METRONIDAZOLE, USP Item No. Size 811519805 25 g 811562805 100 g811556805 500 g

MICONAZOLE, USP Item No. Size 804119805 25 g 804162805 100 g

MINOXIDIL, USP Item No. Size 811619805 25 g 811662805 100 g811643805 1 kg

MUPIROCIN, USP Item No. Size 811737805 1 g 811735805 5 g811719805 25 g

NALTREXONE HYDROCHLORIDE, USP

Item No. Size 808335805 5 g 808319805 25 g808362805 100 g

NIACINAMIDE, USP Item No. Size 815362805 100 g 815356805 500 g815343805 1 kg

NICOTINAMIDE ADENINE DINUCLEOTIDE

Item No. Size 813135805 5 g 813119805 25 g813162805 100 g

NIFEDIPINE, USP (MICRONIZED)

Item No. Size 809519805 25 g 809562805 100 g809556805 500 g

NYSTATIN, USP Item No. Size 811870805 150 MU 811871805 500 MU811872805 1 BU

OMEPRAZOLE, USP Item No. Size 811962805 100 g 811956805 500 g811943805 1 kg

ORPHENADRINE CITRATE, USP

Item No. Size 812019805 25 g 812062805 100 g812056805 500 g

OXYTOCIN, USP Item No. Size 816276805 10 mg 816265805 50 mg816237805 1 g

PENICILLAMINE, USP Item No. Size 814862805 100 g 814856805 500 g814843805 1 kg

PENTOXIFYLLINE, USP Item No. Size 807143805 1 kg 807152805 25 kg

PHENOBARBITAL, USP CIV * Item No. Size 809019805 25 g 809062805 100 g

PHENYLEPHRINE HYDROCHLORIDE, USP

Item No. Size 812219805 25 g 812262805 100 g

PHENYTOIN SODIUM, USP Item No. Size 804362805 100 g

PIROXICAM, USP Item No. Size 816319805 25 g 816362805 100 g816356805 500 g

PREGNENOLONE (MICRONIZED)

Item No. Size 816619805 25 g 816662805 100 g816656805 500 g

PRILOCAINE, USP Item No. Size 803043805 1 kg

PROGESTERONE, USP (MICRONIZED)

Item No. Size 806362805 100 g 806343805 1 kg806360805 5 kg

PROGESTERONE, USP (NON-MIRCRONIZED)

Item No. Size 810562805 100 g 810556805 500 g810543805 1 kg

PROGESTERONE, USP (ULTRA-MICRONIZED)

Item No. Size 816762805 100 g 816756805 500 g816743805 1 kg

PROMETHAZINE HYDROCHLORIDE, USP

Item No. Size 806419805 25 g 806462805 100 g

PYRIDOXINE HYDROCHLO-RIDE, USP (VIT B6)

Item No. Size 816962805 100 g 816956805 500 g816943805 1 kg

RIBOFLAVIN SODIUM PHOSPHATE, USP

Item No. Size 817062805 100 g 817056805 500 g

RIBOFLAVIN, USP Item No. Size 812362805 100 g 812356805 500 g

SILDENAFIL CITRATE, USP Item No. Size 808262805 100 g 808243805 1 kg

SODIUM HYALURONATE (TOPICAL)

Item No. Size 817135805 5 g 817119805 25 g

Page 11: PRODUCT - Humco€¦ · however, pricing and specifications are subject to change without notice. Please contact your Account Manager or visit the website for updated information.

WWW.HUMCO.COM • +1 (855) 925-4736  • HUMCO 11

Product Product Ordering InformationOrdering InformationSODIUM METABISULFITE, NF Item No. Size

809319805 25 g 809362805 100 g809356805 500 g

SPIRONOLACTONE, USP Item No. Size 812419805 25 g 812462805 100 g

STEVIA LEAVES EXTRACT Item No. Size 815262805 100 g 815256805 500 g

SUCRALFATE, USP Item No. Size 815562805 100 g 815543805 1 kg

SUMATRIPTAN SUCCINATE, USP

Item No. Size 808919805 25 g 808962805 100 g

TADALAFIL, USP Item No. Size 808519805 25 g 808562805 100 g808543805 1 kg

TERBINAFINE HYDROCHLORIDE, EP

Item No. Size 817219805 25 g 817262805 100 g

TESTOSTERONE CYPIONATE, USP CIII *

Item No. Size 813719805 25 g 813762805 100 g813756805 500 g

TESTOSTERONE ENANTHATE, USP CIII *

Item No. Size 815062805 100 g 815056805 500 g815043805 1 kg

TESTOSTERONE PROPIONATE, USP CIII *

Item No. Size 810119805 25 g 810162805 100 g

TESTOSTERONE, USP (MICRONIZED) YAM CIII *

Item No. Size 808762805 100 g 808743805 1 kg

TESTOSTERONE, USP (NON-MICRONIZED) CIII *

Item No. Size 812562805 100 g 812556805 500 g812543805 1 kg

TETRACAINE HYDROCHLORIDE, USP

Item No. Size 804662805 100 g 804643805 1 kg

TETRACAINE, USP Item No. Size 818862805 100 g 818856805 500 g818843805 1 kg

THEOPHYLLINE, USP (ANHYDROUS)

Item No. Size 812962805 100 g 812956805 500 g812943805 1 kg

TOPIRAMATE, USP Item No. Size 815119805 25 g 815162805 100 g815156805 500 g

TRAMADOL HYDROCHLORIDE, USP CIV *

Item No. Size 809119805 25 g 809162805 100 g809156805 500 g

TRETINOIN, USP (RETINOIC ACID)

Item No. Size 808435805 5 g 808419805 25 g

UREA, USP Item No. Size 817356805 500 g 817343805 1 kg

URSODIOL, USP Item No. Size 817419805 25 g 817462805 100 g817456805 500 g

VALACYCLOVIR HYDROCHLORIDE, USP

Item No. Size 810362805 100 g 810356805 500 g

VANCOMYCIN HYDROCHLORIDE, USP

Item No. Size 813035805 5 g 813019805 25 g813062805 100 g

VERAPAMIL HYDROCHLORIDE, USP

Item No. Size 805762805 100 g 805743805 1 kg

Please visit www.Humco.com for the most updated list of product offerings.

Page 12: PRODUCT - Humco€¦ · however, pricing and specifications are subject to change without notice. Please contact your Account Manager or visit the website for updated information.

Active Ingredient HRT Botanical

HRTHeavy

LiposomalHeavy

LiposomalRegular

Multi-base

PEN-cream

PLO20Non-Flowable

PLO20 Flowable

RECURA SaltStable LO

SaltStable LS Advanced

Amitriptyline HCl 90

Baclofen 90

Benzocaine 90

Bupivacaine HCl 90

Capsaicin 90

Clomipramine HCl 90 90

Cyclobenzaprine HCl 90 90

Dehydroepiandrosterone 180 90

Dexamethasone 90

Diclofenac 90 90

Diltiazem 90 90

Diphenhydramine HCl 90

Estradiol 90 180

Estriol 120 180

Estrone 150 180

Fluconazole 180

Fluoxetine HCl 90 90

Flurbiprofen 90

Gabapentin 90 90 90 90 90 90

Haloperidol 90 90

Hydroquinone 90

Ibuprofen 90 90 90 90

Ketamine HCl 90

Ketoprofen 90 90 90 90

Lactic Acid 90

Lidocaine 90 90 90

Lidocaine HCl 90

Menthol 90

Methimazole 90 90 90 90

Methyl Salicylate 90

Metoclopramide 90

Metronidazole 90 90 90 90

Miconazole 180

Pentoxifylline 90

Phenytoin 90

Piroxicam 90 90 60

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The Beyond-Use-Date study evaluates the potency and stability of a formula over a course of time, from 30 to 180 days. Below is an alphabetical listing of the API’s studied for stability with correlating bases used for the compounded preparations. Please note, strength depends on percentage of API used. See appropriate product page for details.

STABILITY STUDIES

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Prednisolone 90 90

Prednisone 90 90

Progesterone 180 180 90 90

Promethazine 90 90 90 90

Testosterone 180 180 180

Tetracaine HCl 90 90

Verapamil HCl 90

Active Ingredient HRT Botanical

HRTHeavy

LiposomalHeavy

LiposomalRegular

Multi-base

PEN-cream

PLO20Non-Flowable

PLO20 Flowable

RECURA SaltStable LO

SaltStable LS Advanced

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Item No. NDC No. Size Price6013-56 00395-6013-56 500 g $50.00

Humco’s Anhydrous Base™ is designed for low-load hydrophilic and high-load lipophilic actives that are unstable in water. Compatible with numerous drugs across a broad range of applications, Anhydrous Base™ is cosmetically elegant with an exceptional sensory evaluation profile over other anhydrous bases, providing a smooth, light, and silky feel.

ANHYDROUS BASE™ BENEFITS:• Contains absolutely no water• Non-greasy • Cosmetically elegant – smooth, light, silky feel• Preservative-free & petroleum-free• Easy to use – actives can be directly incorporated without wetting• 180-day BUD with all API’s based on USP 795• Fragrance-free & dye-free

VERSATILE TOPICAL BASE

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ANHYDROUS BASE™Wound

&Scar

Topical/ Transdermal

Bases

ANHYDROUS BASE™ PROPERTIES

Specific Gravity 0.95 Color Light Beige

Transdermal Penetration + + +

API CompatibilityHydrophilic 10% & Lipophilic 20% Total API Load - 20%

Typical Applications• Dermatology • HRT • Pain Management • Sports Medicine • Veterinary Medicine • Wound Care

SAMPLE FORMULAS:

Mixing Tips• Mixing Speed - 1000 rpm for

2-5 minutes• If Dispensing in a Pump,

Airless Pump Dispensers are Recommended

Glutathione 20% Topical

Glutathione (L) Reduced 20% Anhydrous Base qs 100% Recommended Penetration Enhancer: 50% Lecithin in Isopropyl Palmitate

Hydro/Lido/Nife 2.5/1.5/1% Topical

Hydrocortisone 2.5%Lidocaine HCl 1.5%Nifedipine 1%Anhydrous qs 100%

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Topical/ Transdermal

BasesGENEDERM™

GENEDERM™ provides a firming effect on the skin - tightening and smoothing fine lines and wrinkles. It is uniquely formulated with Sodium Polystyrene Sulfonate, a film forming polymer that creates a matrix and provides excellent binding to the skin, allowing the base to adapt to changes in facial expressions and movement without cracking or peeling. GENEDERM™ can be used to reduce the appearance of fine lines and wrinkles. GENEDERM™ BENEFITS:• Suitable for all skin types• Comfortable - Allows skin to breathe• Can be worn for 4-8 hours, including night-time application• Can be applied without API’s for wrinkle treatment• Visible results after first application

DERMATOLOGICAL BASE FOR ANTI-AGING

Item No. NDC No. Size Price6026-56 00395-6026-56 500 g $186.00

GENEDERM™ PROPERTIES

pH 5.0 - 6.0

Viscosity 50,000 - 100,000 cps

Physical Format Light Cream

Color Opaque, Off-White

API CompatibilityHydrophilic 10% & Lipophilic 10% Total API Load - 20%

Typical Applications • Dermatology • Wrinkles

Common Actives in Anti-Aging:

Vitamin E – 200IU/g Antioxidant to reduce the signs of aging and photo-aging

Vitamin C – 2-10% (as Ascorbyl Palmitate) Antioxidant to reduce the signs of aging

Niacinamide – 2% Stabilizing effect on epidermal barrier function, seen as the reduction in trans-epidermal water loss

Estradiol – 0.01% and Estriol 0.3% After treatment for 6 months, elasticity and firmness of the skin had markedly improved; wrinkle depth and pore sized had decreased by 61-100%; skin moisture had increased and wrinkle depth decreased significantly

Alpha-Lipoic Acid – 5% Twelve weeks treatment with a cream improves clinical characteristics related to photo-aging of facial skin

Anit Wrinkle:Alpha-Lipoic Acid 5%Ascorbyl Palmitate 2%Estriol Micro Powder 0.3%Niacinamide 2%Tretinoin 0.025%Propylene Glycol 10%Genederm qs 100%

Acne:Niacinamide 2% Tea Tree Oil 1% Tetracycline 0.22% Tretinoin 0.1%Genederm qs 100%

SAMPLE FORMULAS:

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GENEDERM™CLINICAL STUDY

Clinical Study

STUDYEvaluation of Key Parameters on Outer Parts of 30 Panelist's Eyes, In Vivo, Using Image Analysis In one of the most innovative research projects ever undertaken inmedical aesthetics, ‘The Consumer Product Testing Company' captures the PRIMOS and VISIA image analysis, and opinions on wrinkle length, number, and area from 30 female subjects, ages 35 to 65, with mild to moderate crow's feet (coarse wrinkles) in the outer canthus eye area. The relative skin surface was analyzed as a composite and as a single point in any plane thereby making it possible to examine and compare several cutaneous parameters. The outer parts of the eyes of thirty panelists were used to evaluate several key parameters over eight weeks.

RESULTS'The Consumer Product Testing Company' key findings:

• For women seeking aesthetic treatment, opinions found (89%) positive response for “softened line/wrinkles around eyes, (89%) positive response for “made skin feel firmer/tighter”, and (100%) positive response for “easy to use as daily skin care regimen”.

• PRIMOS image analysis found (71%) of women with wrinkle length decrease.

• VISIA image analysis found (82%) of women with wrinkle number decrease and (79%) of women with wrinkle area decrease.

"Product is non-

irritating and

reduces visibility of

fine lines...

a small amount

goes a long way…

easy to use…

skin feels soft,

smooth, refreshed

and firm…it is not

greasy and has

pleasant smell…it

felt high quality.”

Parameter GenedermTM

Roughness 14% DecreaseResidual Length 9% DecreaseAverage Amplitude 10% Decrease Primary Wrinkle 9% DecreaseNumber of Peaks 10% Reduction

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GENEDERM™ Dermatological Wrinkle Basehas been proven to reduce or decrease five key parame-ters in relation to wrinkle reduction.

View Full Study at www.Humco.com

"The evaluation of parameters indicates that the use of Genederm™ produced smoothing and restructuring of the skin’s surface after seven days of product application." - Advanced Scientific Imaging Consulting, leading analytical laboratory

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Item No. NDC No. Size Price6001-56 00395-6001-56 500 g $38.00 6001-57 00395-6001-57 4.5 kg $240.00

HRT Botanical™ is an oil-in-water, light cream, certified hypoallergenic base, with all natural ingredients and antioxidants. It has a lotion con-sistency and provides sustained skin penetration. Ideal for both male & female lipophilic APIs used in hormone replacement therapy (HRT).

HRT BOTANICAL™ BENEFITS:• Sustained skin penetration and absorption• Paraben-free & fragrance-free• Natural ingredients & natural preservatives• Added antioxidants, botanicals, and herbal extracts• Certified hypoallergenic• Cosmetically elegant• Ideal for topical or vaginal preparations

CERTIFIED HYPOALLERGENIC HRT BASE

HRT BOTANICAL™

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Wound &

Scar

Topical/ Transdermal

Bases

HRT BOTANICAL™ PROPERTIES

pH 6.5

Specific Gravity 1.00

Viscosity 60,000 cps

Physical Format Lotion

Color Light Beige

Transdermal Penetration + +

API CompatibilityLipophilic 20% Total API Load - 20%

Typical Applications • Hormone Replacement

Beyond-Use-Date (BUD)

ACTIVE INGREDIENT BUDEstradiol – 1% 90 DaysEstriol – 1% 120 DaysEstrone – 0.5% 150 DaysPrednisolone – 5% 90 DaysProgesterone – 20% 180 DaysTestosterone – 5% 180 Days

Testosterone 5%:Testosterone 5%HRT Botanical qs 100%

Biest (80/20) 2mg/ml:Estriol 0.16% Estradiol 0.04%HRT Botanical qs 100%

SAMPLE FORMULAS:

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Topical/ Transdermal

BasesHRT HEAVY™

HRT Heavy™ is a heavier cream base than HRT Botanical™; it allows for deep skin penetration and absorption. It is specifically designed for male and female hormone replacement therapy (HRT) and has a moderate to high API carrying capacity. HRT HEAVY™ BENEFITS:• Sustained skin penetration and absorption• Paraben-free & fragrance-free• Natural ingredients & natural preservatives• Certified hypoallergenic• Cosmetically elegant• Ideal for topical or vaginal preparations• Stability/potency of 180 days for common hormone APIs

CERTIFIED HYPOALLERGENIC HRT BASE

Item No. NDC No. Size Price6002-56 00395-6002-56 500 g $38.00 6002-57 00395-6002-57 4.5 kg $240.00 6002-58 00395-6002-58 18 kg $660.00

HRT HEAVY™ PROPERTIES

pH 7.5

Specific Gravity 1.04

Viscosity 165,000 cps

Physical Format Cream

Color White

Transdermal Penetration + + +

API CompatibilityLipophilic 40% Total API Load - 40%

Typical Applications • Hormone Replacement

Beyond-Use-Date (BUD)

ACTIVE INGREDIENT BUDDHEA – 5% 180 DaysEstradiol – 10% 180 DaysEstriol – 10% 180 DaysEstrone – 1% 180 DaysMetronidazole – 2% 90 DaysProgesterone – 40% 180 DaysTestosterone – 20% 180 Days

Biest (80/20) 1.25%:Estriol 1%Estradiol 0.25%HRT Heavy qs 100%

Triest (80/10/10) 3mg/ml: Estriol 0.24% Estradiol 0.03% Estrone 0.03% HRT Heavy qs 100%

SAMPLE FORMULAS:

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180 BUD

Bracket Study

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HORMONESTABILITY STUDY

StudyEvaluation of the physical, chemical and microbiological stability of six hormones contained in HRT Heavy compounding base. The purpose of this study was to evaluate the physical, chemical and mi-crobiological stability of six hormones (Progesterone- P4, Estrone-E1, Es-tradiol-E2, Estriol-E3, DHEA, and Testosterone) contained in HRT Heavy compounding base. The BUD/stability study is being conducted on High Concentrated Hormones (Humco’s HCP*), Low Concentrated Hormones, High Combo, and Low Combo formulations. These high/low/high combo/low combo formulations and the range of hormone concentrations cover majori-ty of the prescription for the hormone therapy. Hormone Concentrates, low concentrations, high combo, and low combo were tested on comprehensive stability study which includes: physical (De-scription, Odor, pH, Weight Loss etc.), Chemical (Potency), and Microbio-logical. All the BUD samples were placed on stability chamber at Controlled Room Temperature (25°C/60%RH) and tested at day 0, 30 days, 60 days, 90 days, 120 days, 170 days and 180 days of storage.

Humco's HCP (Hormone Concentrate Program) is an

innovative line of cream-based concentrates of four main

hormones commonly used in compounding, including

10% Estradiol, 10% Estriol, 40% Progesterone and 20%

Testosterone

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Hormone High Concentration

Low Concentration High Combo Low Combo

E3 - Estriol 100 mg/g 0.5 mg/g 5.25 mg/g 1.4 mg/gm

E2 - Estradiol 100 mg/g 0.5 mg/g 1.5 mg/g 0.4 mg/g

E1 - Estrone 10 mg/g 0.1 mg/g 0.75 mg/g 0.2 mg/g

Testosterone 200mg/g 0.5 mg/g 20 mg/g 0.5 mg/g

Progesterone 400 mg/g 10 mg/g 200 mg/g 10 mg/g

DHEA 50 mg/g 1 mg/g 50 mg/g 1 mg/g

ResultsAll samples met physical testing critria at all testing time-points acording to the Beyond-Use Date Stability testing protocol. Microbiological testing was conducted, including Total Combined Yeast and Mold (USP<61), Total Aerobic Microbial Count (USP<61>), Staphylococcus Aureus and Pseudomonas Aeruginosa (USP <62>) with negative microbiological results. All of the Hormone Concentrate samples, high conc. samples, low conc. samples, high combo, and low combo stored at the Con-trolled Room Temperature met the acceptance criteria (% label of ini-tial concentration: 90-110%) over the 180 day study duration. The above Hormone formulations (high/low/bracketed) are shown to be stable at Controlled Room Temperature for at least 180 days.

Hormone Formulations and Theoretical Amount

HRT HEAVY™ 180 DAYS

BRACKET Beyond-Use Date Study

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Transdermal Study PROGESTERONE

TRANSDERMAL STUDYStudyEvaluation of the Percutaneous Absorption of Progesterone, In Vitro, Using the Epiderm Skin ModelThe progesterone study evaluated the percutaneous ab-sorption pharmacokinetics of progesterone in the following Humco bases: HRT Botanical™, HRT Heavy™, Anhydrous Base™ and PENcream™. Absorption was measured in hu-man epidermal cultures, in vitro, using the finite dose tech-nique and Franz Diffusion Cells.

Formulas were tested on standardized sections for the per-cutaneous absorption of progesterone over a 12-hour dose period. At pre-selected times after dose application, the dermal receptor solution was completely removed and re-placed with fresh receptor solutions; an aliquot was saved for subsequent analysis. Samples were analyzed for proges-terone content by High Performance Liquid Chromatography (HPLC).

The in vitro human Epiderm skin model is a proven tool, valu-able for the study of percutaneous absorption and determina-tion of pharmacokinetics of topically applied drugs. The mod-el uses human epidermal skin mounted in specially designed diffusion cells that allow the skin to be maintained at a tem-perature and humidity that match typical in vitro conditions. A finite dose of formulation is applied to the outer skin surface, and drug absorption is measured by monitoring the rate of appearance in the receptor solution bathing the inner surface of the skin. Data defining total absorption, as well as rate of absorption, can be accurately determined in this model.

Transdermal Drug Absorption:

• Avoids hepatic first pass effect, reducing adverse reactions to certain drugs

• Reduces minor gastrointestinal tract irritation and systemic toxicity

• Helps avoid possible drug interactions with food and intestinal flora

• Can be applied to different parts of the body (site rotation)

Humco’s PENcream™,

Anhydrous Base™,

HRT Heavy™, and

HRT Botanical™

are Validated Transdermal

Vehicles

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PENcream™, Anhydrous Base™, HRT Botanical™, and HRT Heavy™have been proven to transport Progesterone into and through human skin, performing more effec-tively than our competitor's base.

5% PROGESTERONE

Transdermal Study

ResultsThe data did indicate that progesterone penetrated into and through human epidermal cultures, in vitro, from the test formulations provided. The absorption profiles indicate a steady penetration to a peak flux occurring at approximately 12 hours after dose application. HRT Botanical™, HRT Heavy™, Anhydrous Base™, and PENcream™ delivered more progesterone than our competitor's base.

The total percent of applied dose that penetrated past the stratum corneum with our competitor’s base is 20% less than Humco’s HRT Botanical™, HRT Heavy™, Anhydrous Base™, and PENcream™.

Flux

(ug/

cm2/

hr)

Time

Progesterone Flux VS Time

0.00

0.05

0.10

0.15

0.20

0.25

0.30 Competitor’s Base

HRT Botanical

HRT Heavy

Anhydrous Base

PENCream

1284

% Progesterone Permeation Through the Stratum Corneum

% P

erm

eatio

n

Progesterone

Com

petit

or’s

Base

HRT

Bot

anic

al™

HRT

Hea

vy™

Anhy

drou

s Ba

se™

PEN

Crea

m ™

Competitor’s BaseHRT BotanicalHRT Heavy

Humco's Anhydrous BasePENCream

0.40

0.20

0.00

1.00

0.80

0.60

1.60

1.40

1.20

View Full Study at www.Humco.com

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LIPOSOMAL HEAVY™

Liposomal Heavy™ is formulated with additional emulsifiers to allow for higher API loads and solvent concentrations to be incorporated. Added emollients provide excellent moisturization—an ideal choice for dry and/or dehydrated skin. LIPOSOMAL HEAVY™ BENEFITS:• Cosmetically elegant – excellent moisturizing effect • Faster absorption & deeper penetration than HRT bases• API compatibility – virtually all actives• Natural preservatives• Water & oil-soluble• Ideal for cosmetic facial applications• Paraben-free

MOISTURIZING LIPOSOMAL BASE

Item No. NDC No. Size Price6004-56 00395-6004-56 500 g $50.00 6004-57 00395-6004-57 4.5 kg $365.00 6004-58 00395-6004-58 18 kg $1310.00

Topical/ Transdermal

Bases

LIPOSOMAL HEAVY™ PROPERTIES

pH 6.0

Specific Gravity 1.00

Viscosity 250,000 cps

Format Heavy Cream

Color White

Transdermal Penetration + + + +

API CompatibilityHydrophilic 10% &Lipophilic 10%Total API Load – 20%

Typical Applications• Dermatology• Pain Management

Recommended Use• Higher API Loads• Dry/Dehydrated Skin• Chemical Peels• Pigmentation Treatments

Mixing Tip• Recommended to Reduce Oxidation:

Sodium Bisulfite - 0.5%

Beyond-Use-Date (BUD)

ACTIVE INGREDIENT BUDDexamethasone – 1.5% 90 DaysDiclofenac – 4% 90 DaysDiltiazem – 2% 90 DaysGabapentin – 6% 90 DaysHaloperidol – 0.1% 90 DaysHydroquinone – 5% 90 DaysPiroxicam – 0.5% 90 DaysPromethazine – 5% 90 Days

Eczema Cream:Tacrolimus 0.2%Liposomal Heavy qs 100%

Skin Lightening Cream:Hydroquinone 10% Kojic Acid 3%Tretinoin 0.05%Liposomal Heavy qs 100%

SAMPLE FORMULAS:

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Topical/ Transdermal

BasesLIPOSOMAL REGULAR™

Liposomal Regular™ is a cosmetically elegant, liposomal transdermal base with excellent skin penetration and moisturizing capabilities. It is formulated to incorporate lipophilic and hydrophilic actives and penetrate deeper and faster than HRT bases.

LIPOSOMAL REGULAR™ BENEFITS:• Cosmetically elegant – excellent moisturizing effect • Faster absorption & deeper penetration than HRT bases• API compatibility – virtually all actives• Natural preservatives• Water & oil-soluble• Ideal for cosmetic facial applications• Paraben-free

MOISTURIZING LIPOSOMAL BASE

Item No. NDC No. Size Price6003-56 00395-6003-56 500 g $50.00 6003-57 00395-6003-57 4.5 kg $365.00 6003-58 00395-6003-58 18 kg $1310.00

Beyond-Use-Date (BUD)

ACTIVE INGREDIENT BUDDehydroepiandrosterone – 1.25% 90 DaysGabapentin – 12.3% 90 DaysMethimazole – 5% 90 DaysProgesterone – 5% 90 Days

LIPOSOMAL REGULAR™ PROPERTIES

pH 7.5

Specific Gravity 1.00

Viscosity 120,000 cps

Format Light Cream

Color Off-White

Transdermal Penetration + + +

API CompatibilityHydrophilic 5% &Lipophilic 5%Total API Load – 10%

Typical Applications• Dermatology• Pain Management• Hormone Therapy• Veterinary Medicine

Recommended Use • Lower API Loads• Cosmetic Preparations

Veterinary Cream: Methimazole 5%Liposomal Regular qs 100%

Pain Management Cream:Gabapentin 6% Liposomal Regular qs 100%

SAMPLE FORMULAS:

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MULTIBASE™

A versatile, oil-in-water natural vanishing cream that uses oleosomic emulsifiers and penetration enhancers. It is an oil-free moisturizing base that provides natural skin penetration. MultiBase™ is designed for both hydrophilic and lipophilic actives and exhibits superior stabil-ity in the presence of low-pH, high-pH, and high-alcohol compounds, allowing for flexible compounding and formulation options.

MULTIBASE™ BENEFITS:• Mineral oil-free, gluten-free, and propylene glycol-free• Noncomedogenic• Enhanced drug absorption & penetration• Ideal for topical & vaginal preparations• Stable over a broad range pH• API compatibility – hydrophilic & lipophilic• Natural ingredients – moisturizers derived from berries, grapes, plums, and pears & emulsifiers derived from vegetable fatty acids& palm oil; thickening agents derived from coconut oil

VERSATILE OIL-IN-WATER BASE

Item No. NDC No. Size Price6015-56 00395-6015-56 500 g $45.00 6015-57 00395-6015-57 4.5 kg $380.00

Topical/ Transdermal

Bases

MULTIBASE™ PROPERTIES

pH 7.0

Specific Gravity 0.90

Viscosity 250,000 cps

Physical Format Heavy Cream

Color White

Transdermal Penetration + +

API CompatibilityHydrophilic 10% & Lipophilic 20% Total API Load - 30%

pH Compatibility 3.0 - 11.0

Salt Tolerance Salt Forms - 10%

Typical Applications• Hormone Replacement • Dermatology • Pain Management

Beyond-Use-Date (BUD)ACTIVE INGREDIENT BUD

Capsaicin – 1.2% 90 Days

Lactic Acid – 8.5% 90 Days

Lidocaine – 8% 90 Days

Menthol – 8% 90 Days

Methyl Salicylate – 20% 90 Days

Metronidazole – 8% 90 Days

Phenytoin – 8% 90 Days

Progesterone – 10% 90 Days

Testosterone – 2% 180 Days

HRT Cream:Progesterone 20%Glycerin 10%Multibase qs 100%

Analgesic Cream:Capsicum Oleoresin 0.6% Methyl Salicylate 10%Menthol 4%Multibase qs 100%

SAMPLE FORMULAS:

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Topical/ Transdermal

BasesPENCREAM™

PENcream™ is an elegant oil-in-water vanishing cream formulated for enhanced transdermal penetration and absorption. This elegant alternative to PLO, with added emollients, provides a better rub-in and longer-lasting moisturizing effects without irritation. PENcream™ is compatible with a diverse range of hydrophilic and lipophilic actives, has a high API load capacity, and is ideal for hybrid formulations.

PENCREAM™ BENEFITS:• Free of BHT, EDTA, parabens, and urea• Enhanced penetration capability – efficacious API absorption• Hydrophilic & lipophilic compatibility – high loads• Natural ingredients – less irritation than PLO• Cosmetically elegant – lasting moisturizing effect• Applies easily – no sticky residue

VANISHING OIL-IN-WATER BASE

Item No. NDC No. Size Price6010-56 00395-6010-56 500 g $25.00 6010-57 00395-6010-57 4.5 kg $250.00 6010-58 00395-6010-58 18 kg $1000.00

PENCREAM™ PROPERTIES

pH 7.0

Specific Gravity 0.96

Viscosity 300,000 cps

Physical Format Heavy Cream

Color White

Transdermal Penetration + + + +

API CompatibilityHydrophilic & Lipophilic Total API Load - 30%

Typical Applications • Pain Management • Veterinary Medicine

Beyond-Use-Date (BUD)ACTIVE INGREDIENT BUD

Clomipramine HCl– 7.5% 90 Days

Fluoxetine HCl– 7.5% 90 Days

Gabapentin – 6% 90 Days

Ibuprofen – 10% 90 Days

Ketoprofen - 10% 90 Days

Lidocaine – 15% 90 Days

Methimazole – 7.5% 90 Days

Metoclopramide – 2% 90 Days

Metronidazole – 3% 90 Days

Promethazine – 5% 90 Days

Tetracaine HCl– 2% 90 Days

Mixing Tips• Water Soluble Powders:

If needed, may levigate with Alcohol, Dimethyl Sulfoxide (DMSO), Glycerin, Polyethylene Glycol (PEG) 300 or 400, Propylene Glycol, or Purified Water

• Oil-Soluble Powders Can be Directly Incorpo-rated

SAMPLE FORMULAS:

Veterinary Cream:Methimazole 7.5%Pencream qs 100%

Pain Management Cream:Amitriptyline 2%Diclofenac 1%Gabapentin 5%Pencream qs 100%

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RECURA™Topical/

Transdermal Bases

RECURA™ topical cream is an innovative compounding delivery vehicle created for creams compounded to treat conditions such as onychomycosis. Utilizing penetration enhancers, RECURA™ pro-vides good penetration into toenails, fingernails, and skin, works well with a variety of antifungal agents, and compounds easily. It has been intensively studied, patented, and peer-reviewed in order to validate the compatibility of the cream with a number of active ingredients.

RECURA™ BENEFITS:• Penetration Ability - contains penetration enhancers and natural oils to facilitate active drug absorption• Drug Compatibility - both oil and water soluble powders can be levigated with alcohol• Compound Diversity - contains penetrating agents for better nail absorption, natural oils for better skin absorption, and is alcohol- dispersible for viscosity adjustment

ANTIFUNGAL BASE

Item No. NDC No. Size Price6020-56 00395-6020-56 500 g $250.00 6020-59 00395-6020-59 2.5 kg $750.00

RECURA™ PROPERTIES

pH 7.0 - 9.0

Physical Format Viscous Cream

Color Grey, Light Lavender

Typical Applications Fungal treatment on toenails, fingernails, and skin

Nail Cream 1:Miconazole 3 gmRecura 27 gm

Nail Cream 2:Fluconazole 3 gm Recura 27 gm

Skin Cream:Clotrimazole 0.6 gm Ibuprofen 0.6 gmRecura 28.8 gm

SAMPLE FORMULAS:

RECURA™ Peer

Reviewed Studies:

• IJPC, Jan/Feb

2016, Pgs 71-80

• IJPC, Mar/Apr 2017,

Pgs 154-159

View Full Study at www.Humco.com

Published Studies – Beyond-Use-Date (BUD)

ACTIVE INGREDIENT BUDFluconazole – 10% 180 DaysMiconazole – 10% 180 Days

Mixing Tips• pH of 9 is best for optimal

penetration through the nail • reduce pH to 6-7 for treating

infections on the skin by adding 1-2% citric acid

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Creams &

LotionsYour Compounding Vehicle to help you

TOPICAL COMPOUNDING CREAM

ABOUT RECURA• RECURA can be formulated to hold and help in the delivery of various antifungal active ingredients

• In Vitro testing in a novel nail model suggests the potential utility of RECURA topical cream to enhance delivery of antifungal actives across the nail

• Peer reviewed study1 in in vitro nail models comparing drug absorption with RECURA vs. marketed prescription solutions

• RECURA is for topical use only and is not for oral, ophthalmic, or intravaginal use

1 Turner R et al., A Novel Vehicle for Enhanced Drug Delivery Across the Human Nail for the Treatment of Onychomycosis, INTL. J. PHARM. COMPOUNDING 2016;20(1):71-80

Manufactured By:

Humco | 512 E 11th St, Ste 201, Austin, Texas 78701 - USATel. (512)474-7400 | Fax (512)474-7414

[email protected] | www.Humco.com

RECURA topical cream is an innovative compounding delivery vehicle created for creams compounded to treat conditions such as onychomycosis.

WWW.HUMCO.COM • +1 (855) 925-4736  • HUMCO 29

View Full Study at www.Humco.com

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30 HUMCO   •    +1 (855) 925-4736   •    WWW.HUMCO.COM

SALTSTABLE LO™Topical/

Transdermal Bases

SaltStable LO™ is a ready-to-use transdermal cream base providing an elegant alternative to traditional PLOs. It is uniquely designed with a long shelf life and is temperature stable. It will not separate in the presence of high levels of ionic substances or when refrigerated. Added emulsifiers and hydrocolloids provide a chemical penetration enhancer (CPE) value superior to a PLO. SaltStable LO™ is cosmeti-cally elegant and compatible with both hydrophilic and lipophilic APIs allowing for compounding flexibility.

SALTSTABLE LO™ BENEFITS:• Efficacious active drug absorption• In vitro transdermal penetration & API compatibility• Temperature stable & shelf stable• Hydrophilic compatibility – high levels of ionic powders can be directly incorporated • Lipophilic compatibility – moderate levels of oil-soluble powders can be levigated with glycerin, propylene glycol, polyethylene glycol (PEG) 300 or 400, or alcohol• Cosmetically elegant – not tacky or sticky• Natural ingredients – resulting in less irritation

TRANSDERMAL PAIN MANAGEMENT BASE

Item No. NDC No. Size Price6009-56 00395-6009-56 500 g $75.00 6009-57 00395-6009-57 4.5 kg $450.00 6009-58 00395-6009-58 18 kg $1600.00

SALTSTABLE LO™ PROPERTIES

pH 7.0

Specific Gravity 1.00

Viscosity 300,000 cps

Physical Format Heavy Cream

Color Light Yellow

Transdermal Penetration + + + +

API CompatibilityHydrophilic 35% & Lipophilic 10% Total API Load 35%

Typical Applications• Pain Management • Veterinary Medicine • Sports Medicine

Beyond-Use-Date (BUD)ACTIVE INGREDIENT BUD

Amitriptyline HCl – 2% 90 Days

Benzocaine – 20% 90 DaysClomipramine HCl – 5% 90 Days

Cyclobenzaprine HCl – 2% 90 Days

Diphenhydramine HCl – 10% 90 Days

Fluoxetine HCl – 5% 90 DaysGabapentin – 6% 90 Days

Ketoprofen – 10% 90 Days

Lidocaine – 10% 90 Days

Methimazole – 5% 90 Days

Metronidazole – 2% 90 Days

Promethazine – 5% 90 Days

Tetracaine HCl – 4% 90 Days SAMPLE FORMULAS:

BLT:Benzocaine 20%Lidocaine 6%Tetracaine 4%SaltStable LO qs 100%

Lorazepam Formula:Lorazepam 0.5%SaltStable LO qs 100%

Pain Management Cream:Baclofen 2%Diclofenac 3%Gabapentin 3%Citric Acid 2%Ethoxy Diglycol 8%Salt Stable LO qs 100%

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Topical/ Transdermal

Bases

SALTSTABLE LS ADVANCED™

SaltStable LS Advanced™ is an extension and enhancement of SaltStable LO™. SaltStable LS Advanced™ is a scientifically advanced, extremely durable, robust and versatile transdermal cream base formulated with a silogel that provides a smooth, silky dry feel. SSLS Advanced™ is designed for all actives and is non-specific to salt; it also exhibits superior API carrying capacity (high loads) of multiple actives in one formulation. SaltStable LS Advanced™ demonstrates excellent stability without the need to add emulsifiers.

SALTSTABLE LS ADVANCED™ BENEFITS:• Increased stability with a high percent of APIs & multiple actives• Validated in vitro transdermal vehicle up to 8 APIs in one formulation • Less sticky & less tacky because of silogel (silicone-based organogel)• Off-white, cosmetically elegant cream• API compatibility – compatible with all actives, non-specific to salt• Time saving – ready-to-use base, no need for wetting or adding thickening agents • Ideal for formulations with multiple actives & high API loads

TRANSDERMAL PAIN MANAGEMENT BASE

Item No. NDC No. Size Price6021-56 00395-6021-56 500 g $90.00 6021-57 00395-6021-57 4.5 kg $525.00 6021-58 00395-6021-58 18 kg $1890.00

SALTSTABLE LS ADVANCED™ PROPERTIES

pH 7.1 - 7.5

Specific Gravity 0.90

Viscosity 1,200,000 cps

Physical Format Heavy Cream

Color Off White

Transdermal Penetration + + + +

API CompatibilityHydrophilic 30% & Lipophilic 40% Total API Load - 40%

Typical Applications• Pain Management • Veterinary Medicine • Sports Medicine

Beyond-Use-Date (BUD)ACTIVE INGREDIENT BUD

Baclofen – 2% 90 Days

Bupivacaine HCL – 1% 90 Days

Cyclobenzaprine HCl – 2% 90 Days

Diclofenac – 5% 90 Days

Flurbiprofen – 10% 90 Days

Gabapentin – 10% 90 Days

Ibuprofen – 3% 90 Days

Ketamine HCl – 10% 90 Days

Ketoprofen – 20% 90 Days

Lidocaine HCl – 5% 90 Days

Pentoxyfylline – 3% 90 Days

Verapamil HCl– 10% 90 Days

Baclofen 2%Bupivacaine 1%Diclofenac 5%Gabapentin 6%Ibuprofen 3%Ketamine HCl 10%Pentoxifylline 3%SSLS Advanced qs 100%

Baclofen 2%Clonidine 0.2%Gabapentin 10%Ketamine 5%SSLS Advanced qs 100%

Diclofenac 5%Ibuprofen 3%Pentoxifylline 3%Verapamil 10%SSLS Advanced qs 100%

Baclofen 2%Flurbiprofen 10%Lidocaine HCl 5%Pentoxifylline 3%SSLS Advanced qs 100%

SAMPLE FORMULAS (90 DAYS):

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Transdermal Study

STUDYEvaluation of the Percutaneous Absorption of Pentoxifylline + Ketamine HCl + Ibuprofen + Cyclobenzaprine HCl + Diclofenac Na + Baclofen + Bupivacaine HCl + Gabapentin, In SaltStable LS Advanced™, Into Human Skin, In Vitro, Using the Franz Skin Finite Dose Model

Using Humco’s SaltStable LS Advanced™, the study was designed to evaluate the percutaneous absorption pharmacokinetics of pent-oxifylline, ketamine HCl, ibuprofen, cyclobenzaprine HCl, diclofenac Na, baclofen, bupivacaine HCl and gabapentin in a single formula-tion using Humco’s SaltStable LS Advanced™ base. Absorption was measured in human epidermal cultures, in vitro, using the finite dose technique and Franz Diffusion Cells. The eight drugs were selected due to their frequent use in compounding topical pain formulations along with compoundingmultiple actives in one formulation. The formula was tested on standardized sections with Humco’s SaltStable LS Advanced™ transdermal compounding base, for the percutaneous absorption of the formula over a 48-hour dose period. At pre-selected times after dose application, the dermal receptor solution was removed in its entirety, replaced with fresh receptor solution, and an aliquot saved for subsequent analysis. High Performance Liquid Chromatography (HPLC) analyzed the samples for pentoxifylline, ketamine HCl, ibuprofen, cyclobenzaprine HCl, diclofenac Na, baclofen, bupivacaine HCl and gabapentin content.

The in vitro human Epiderm skin model has proven to be a valuable tool for the study of percutaneous absorption and the determination of the pharmacokinetics of topically applied drugs. The model uses human epidermal skin mounted in specially designed diffusion cells that allow the skin to be maintained at a temperature and humidity that match typical in vitro conditions. A finite dose of formulation is applied to the outer surface of the skin and drug absorption is mea-sured by monitoring the rate of appearance in the receptor solution bathing the inner surface of the skin. Data defining total absorption, as well as rate of absorption can be accurately determined in this model.

SALTSTABLE LS ADVANCED™TRANSDERMAL STUDY

RESULTS Humco’s SaltStable LS Advanced™ compounding base is a proven trans-dermal delivery vehicle able to deliver multiple drugs beyond the stratum corneum, simultaneously into and through the human skin after a single dose. The data indicates that Humco’s SaltStable LS Advanced™ delivered pentoxifylline, ketamine HCl, ibuprofen, cycloben-zaprine HCl, diclofenac Na, baclofen, bupivacaine HCl, and gabapentin simultaneously (and intact) into and through human epidermal cultures, in vitro, from the test formulation provided. The absorption profiles indicate pentoxifylline, ketamine HCl, ibuprofen, diclofenac Na, and bupivacaine HCl had a steady penetration occurring for 32 hours after dose application. And cyclobenzaprine HCl, baclofen and gabapentin had a steady penetration occurring for 48 hours after dose application.

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Creams &

Lotions

TESTED FORMULA

Baclofen.......................2%Bupivacaine ................1% Cyclobenzaprine HCl.2% Diclofenac Na..............5% Gabapentin..................6% Ibuprofen.....................3% Ketamine HCl............10% Pentoxifylline...............3%SaltStable LS Advanced.....qs 100%

Breakthrough Study: SaltStable LS Advanced™has been proven to deliver eight drugs simultaneously through human skin in-vitro.

Flux

(ug/

cm2/

hr)

Time

Baclofen Flux VS Time

0.000

0.005

0.010

0.015

0.020

0.025

0.030SaltStable LS

ActiveMax

48322412842

Flux

(ug/

cm2/

hr)

Time

Bupivacaine Flux VS Time

0.00

0.05

0.10

0.15SaltStable LS

ActiveMax

483224128420

Flux

(ug/

cm2/

hr)

Time

Cyclobenzaprine Flux VS Time

Flux

(ug/

cm2/

hr)

Time

Diclofenac Flux VS Time

Flux

(ug/

cm2/

hr)

Time

Gabapentin Flux VS Time

Flux

(ug/

cm2/

hr)

Time

Ibuprofen Flux VS Time

Flux

(ug/

cm2/

hr)

Time

Ketamine Flux VS Time

Flux

(ug/

cm2/

hr)

Time

Pentoxifylline Flux VS Time

0.00

0.05

0.10

0.15

0.20

0.25

0.30

0.35SaltStable LS

ActiveMax

483224128420 0.00

0.20

0.40

0.60

0.80

1.00

4832241284200.000

0.020

0.040

0.060

0.080SaltStable LS

ActiveMax

483224128420

0.0

1.0

2.0

3.0

4.0SaltStable LS

ActiveMax

4832241284200.0

1.0

2.0

3.0

4.0SaltStable LS

ActiveMax

4832241284200.0

2.0

4.0

6.0SaltStable LS

ActiveMax

483224128420

Page 34: PRODUCT - Humco€¦ · however, pricing and specifications are subject to change without notice. Please contact your Account Manager or visit the website for updated information.

34 HUMCO   •    +1 (855) 925-4736   •    WWW.HUMCO.COM

Topical/ Transdermal

Bases LAVARE™WATER-WASHABLE WOUND CARE BASE

Lavare™ is a Polyethylene Glycol (PEG) based occlusive, water soluble gel specifically formulated for wound management by promot-ing a moist environment allowing for optimal healing. Lavare™ con-tains organic Meadowsweet Extract potentially providing germicidal, anti-inflammatory, and healing properties along with the ability to deliver APIs topically to sensitive wound sites. LAVARE™ BENEFITS:• Adherent base – occlusive• Water-washable allowing for easy cleaning and debridement• Maintains a moist wound site providing an optimal healing environment• API Compatibility – hydrophilic and lipophilic actives• Soy and gluten free

Item No. NDC No. Size Price7001-56 00395-7001-56 500 g Call for Price 7001-59 00395-7001-59 2.5 kg Call for Price

LAVARE ™ PROPERTIES

pH 6.0

Specific Gravity 1.12

Physical Format Non-Flowable Gel

Solubility in Water Complete

Color White

Typical Applications • Wounds • Ulcers • Burns • Cuts • Abrasions • Dermatological Applications

No Odor/ No Pain:Misoprostol 0.0024%Phenytoin 5%Lavare Gel qs 100%

Odor / No Pain:Misoprostol 0.0024% Phenytoin 5% Metronidazole 2% Lavare Gel qs 100%

No Odor / Pain:Misoprostol 0.0024% Phenytoin 5%Lidocaine 4%Lavare Gel qs 100%

Infected Wound:Misoprostol 0.0024%Phenytoin 5%Gentamicin 0.2%Lavare Gel qs 100%

Infected Wound: Gentamicin 0.1%/gClindamycin 0.1%/gPolymyxin 2,000 u/gLavare Gel qs 100%

Wound Care:Ketoprofen 2%Lidocaine 2%Misoprostol 0.0024%Phenytoin 2%Aloe Vera 0.2%Lavare Gel qs 100%

SAMPLE FORMULAS: Dosage: Apply up to 4 grams topically 3 times daily as directed, up to 12 grams per day.

Misoprostol – 0.0024% Synthetic analogue of prostaglandin E1, attenuate the inflammatory process and promotes collagen formation by inhibiting IL-1 and TNF, modulates inflammation and decreases wound healing time

Phenytoin – 5% Stimulates collagen deposition, fi-broblast proliferation, glucocorticoid antagonism, and has antibacterial activity

Lidocaine – 4% – Topical anesthetic

Metronidazole – 2% Deodorizing effect of Metronidazole correlate with eradication of anaerobic infection

Nifedipine – 2% Ca2+ channel blocker that greatly improves tissue perfusion and improves healing time

Gentamicin – 0.2% – Antibiotic

Common Actives in Wound Care:

Mixing Tip• Recommended Wetting Agent: Glycerin, Maximum Amount 10%

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Common Actives in Scar Care:

Pentoxifylline – 0.1 – 0.5% Decreases collagen production, increases activity of collagenase in dermis, inhibits fibroblast hyperactivity

Betamethasone – 0.1% Steroid and anti-inflammatory

Dimethyl Sulfone – 2% Anti-inflammatory

EGCg – 0.1 – 0.5% – Antioxidant

Caffeine – 0.1 – 1% Induces differentiation and proliferation in epidermal keratino-cytes

Collagenase – 350 u/g Reduces collagen production

Hyaluronidase – 250 u/g Breaks down collagen

Tranilast – 1 – 10% Antioxidant, decreases redness and swelling, inhibits collagen synthesis

Topical/ Transdermal

Bases

SCAR THERAPY BASE

SANARE ADVANCED™

Sanare Advanced™ is an elegant, topical anhydrous silicone gel designed for scar therapy treatment and management. It is uniquely formulated with Carapa Guaianensis Seed Oil found in the Amazon rainforest, an exceptional ingredient that promotes skin renewal, inflammation reduction, and healing. Added emollients and emulsifi-ers allow for versatile compounding for scar and other skin conditions.

SANARE ADVANCED™ BENEFITS:• Provides barrier protection• Increased skin penetration• Formulated for higher loads of polar salt APIs• Skin renewal and inflammation reduction• Soy, gluten, and irritant free• 180-day BUD based on USP 795

SANARE ADVANCED™ PROPERTIES

Specific Gravity 1.12

Physical Format Viscous Gel

Solubility in Water Insoluble

Color Opaque, Off-White

Typical Applications• New Scars • Old Scars • Surgical Scars • Acne Scars • Keloids • Stretch Marks • Scar Tissue • Dermatological Applications

Keloids & Hypertrophic Scars:Betamethasone Valerate 0.1%Tranilast 1%Sanare Advanced qs 100%

Post–Surgical Scars/ New Scars:Collagenase 350 u/gHyaluronidase 250 u/gSanare Advanced qs 100%

Post–Surgical Scars with Pain:Gabapentin 15%Lidocaine 3%Prilocaine 3%Sanare Advanced qs 100%

Age Spots & Wrinkles:Hydroquinone 8%Hydrocortisone 1%Kojic Acid 4%Tretinoin 0.05%Sanare Advanced qs 100%

Rosacea:Metronidazole 1%Niacinamide 4%Sanare Advanced qs 100%

Acne Scars:Lipoic Acid 0.5%Tretinoin 0.1%Sanare Advanced qs 100%

SAMPLE FORMULAS: Dosage: Apply 2-6 grams topically to affected area 2-4 times daily for 10 to 14 weeks or as directed.

Mixing Tips• Recommended Wetting Agent:Fatty Acid Esters (Isopropyl Palmitate), Fatty Alcohols (Oleyl Alcohol), or Anhydrous Alcohol (Ethanol 200 Proof) - Maximum Amount 10%

• Recommended to Reduce Stickiness: Cyclomethicone 5 - 10%

Item No. NDC No. Size Price0112-56 00395-0112-56 500 g Call for Price 0112-59 00395-0112-59 2.5 kg Call for Price 0112-31 00395-0112-31 5.8 kg Call for Price

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STUDYEvaluation of the Percutaneous Absorption of Flurbiprofen + Lidocaine

The study evaluated the percutaneous absorption pharmacokinetics of Humco’s Sanare Advanced™ Scar Base. Absorption was measured in human epidermal cultures, in vitro, using the finite dose technique and Franz Diffusion Cells.

The formula was tested on standardized sections with two different transdermal compounding bases. At pre-selected times after dose application, the dermal receptor solution was completely removed and replaced with fresh receptor solution; and an aliquot was saved for subsequent analysis. Samples were analyzed for flurbiprofen and lidocaine content by High Performance Liquid Chromatography (HPLC).

The in vitro human Epiderm skin model is a proven tool, valuable for the study of percutaneous absorption and determi-nation of pharmacokinetics of topically applied drugs. The model uses human epidermal skin mounted in specially designed diffusion cells that allow the skin to be maintained at a temperature and humidity that match typical in vitro conditions. A finite dose of formulation is applied to the outer skin surface, and drug absorption is measured by monitoring the rate of appearance in the receptor solution bathing the inner surface of the skin. Data defining total absorption, as well as rate of absorption, can be accurately determined in this model.

Transdermal Study SANARE ADVANCED™

TRANSDERMAL STUDY

36 HUMCO   •    +1 (855) 925-4736   •    WWW.HUMCO.COM

TESTED FORMULA

Flurbiprofen ...............................10%Lidocaine ......................................5%Sanare Advanced™...........qs 100%

Sanare

Advanced™

out-performs

Competitor’s

Base

by 23-28%

View Full Study at www.Humco.com

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SANARE ADVANCED™ Scar Therapy Base

WWW.HUMCO.COM • +1 (855) 925-4736  • HUMCO 37

0

5

10

15

20

25

30

35

40

45Sanare Advanced

Competitor's Base

483224128420

Flurbiprofen Flux VS Time

10% FLURBIPROFEN

Transdermal Study

5% LIDOCAINE

Transdermal Study

has been proven to transport multiple drugs into and through human skin, performing significantly more effectively than our competitor’s base.

Lidocaine Flux VS Time

0

2

4

6

8

10Sanare Advanced

Competitor's Base

483224128420

RESULTSThe data did indicate that flurbiprofen penetrated into and through human epidermal cultures, in vitro, from the test formulations provided. The absorption profiles indicate a steady penetration for 48 hours after dose application. Sanare Advanced™ performed significantly better than our competitor's base at delivering flurbiprofen through human skin.

The data also indicated that lidocaine penetrated into and through human epidermal cultures, in vitro, from the test formulations provided. The absorption profiles indicate a steady penetration for 48 hours after dose application. Humco’s Sanare Advanced™ performed significantly better than our competitor’s base at delivering lidocaine through human skin.

The total percent of applied dose that penetrated past the stratum corneum with our com-petitor’s base is 23% less with flurbiprofen and 28% less with lidocaine than Humco’s Sanare Advanced™.

Flux

(ug/

cm2/

hr)

Time

Flux

(ug/

cm2/

hr)

Time

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PLO20 FLOWABLE™Topical/

Transdermal Bases

PLO20 Flowable™ is a robust, ready-to-use transdermal base that represents the next generation of pluronic lecithin organogel (PLO) bases. This cosmetically elegant base has a lotion consistency that allows for incorporating high levels of APIs. It contains the same stability properties as PLO20 Non-Flowable™, allowing for versatile compounding. PLO20 Flowable™ provides enhanced chemical penetration that allows a deeper skin permeation than does PLO20 Non-Flowable™. This product is designed to accept the incorporation of high levels of lipophilic actives and moderate levels of hydrophilic actives.

PLO20 FLOWABLE BENEFITS: • Enhanced penetration – more efficacious drug absorption• API compatibility – high lipophilic & moderate hydrophilic carrying capacity• Adjustable viscosity – PLO20™ & PLO20 Flowable™ may be blended• Temperature & shelf stable• Cosmetically elegant• Validated API compatibility & penetration• No wetting or milling – high levels of oil-soluble powders & moderate levels of water-soluble powders may be directly incorporated

PRE-MADE FLOWABLE PLO BASE

Item No. NDC No. Size Price0135-56 00395-0135-56 500 g $65.00

Humco's PLO20 Flowable™ ....... 44%Competitor’s Base ........ 39%Traditional PLO ............. 17%

Cumulative % Permeation of

Methimazole through the Stratum Corneum

HUMCO'S PLO20 FLOWABLE™

VS TRADITIONAL PLO

& COMPETITOR'S BASE

Fluoxetine 5mg/0.1ml

Fluoxetine HCl 5%Grain Alcohol 2%PLO20 Flowable qs 100%

SAMPLE FORMULA:

PLO20 FLOWABLE™ PROPERTIES

pH 7.0

Specific Gravity 0.97

Viscosity 30,000 cps

Physical Format Light Cream/Lotion

Color Light Yellow

Transdermal Penetration + + + + +

API CompatibilityHydrophilic 10% Lipophilic 30% Total API Load 30%

Typical Applications• Pain Management • Veterinary Medicine • Sports MedicineBeyond-Use-Date (BUD)

ACTIVE INGREDIENT BUD

Haloperidol – 2% 90 Days

Ibuprofen – 20% 90 DaysMethimazole – 5% 90 Days Piroxicam – 2% 60 Days Prednisone – 10% 90 Days

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Topical/ Transdermal

BasesPLO20 NON-FLOWABLE™

PLO20 Non-Flowable™ is a ready -to- use, absorption- enhanced transdermal vehicle that is an elegant alternative to PLO transdermal systems. It contains penetration enhancers to facilitate more efficacious active drug absorption, emollients for a better rub- in, preservatives for increased mold resistance, along with emulsifiers allowing for better cold- temperature stability. PLO20 Non-Flowable™ may be blended for viscosity optimization without wetting agents or milling to thin the formula, thus allowing for versatile compounding.

PRE-MADE PLO BASE

Item No. NDC No. Size Price6008-56 00395-6008-56 500 g $50.00 6008-57 00395-6008-57 4.5 kg $365.00

• When you want more efficacious active drug absorption.• When you want to incorporate high levels of lipophilic substances.• When you want a creamier base than a traditional PLO that is more cosmetically elegant and less sticky.• When you want a penetrating cream that can be shipped in cold temperatures.

WHEN DO YOU NEED PLO20™ OR PLO20 FLOWABLE™?

Anti-Nausea/Pain Management Cream:Promethazine 5%PLO20 Non-Flowable qs 100%

SAMPLE FORMULA:

PLO20 NON-FLOWABLE™ PROPERTIES

pH 7.0

Specific Gravity 0.97

Viscosity 300,000 cps

Physical Format Heavy Cream

Color Light Yellow

Transdermal Penetration + + + +

API CompatibilityHydrophilic 10% Lipophilic 10% Total API Load 10%

Typical Applications

• Pain Management • Veterinary Medicine • Sports Medicine • Diabetes & Wound Care

Beyond-Use-Date (BUD)ACTIVE INGREDIENT BUD

Diltiazem – 2% 90 Days

Gabapentin – 6% 90 DaysIbuprofen – 10% 90 Days Ketoprofen – 10% 90 Days Piroxicam – 1% 90 DaysPrednisolone – 5% 90 DaysPrednisone – 5% 90 DaysPromethazine – 5% 90 Days

PLO20 NON-FLOWABLE™ BENEFITS:• API compatibility – moderate lipophilic & moderate hydrophilic carrying capacity • Temperature & shelf stable• Cosmetically elegant• Validated API compatibility & penetration• No wetting or milling – high levels of oil-soluble powders & moderate levels of water-soluble powders may be directly incorporated

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UNIVERSAL WATER GEL™

Topical/ Transdermal

Bases

Universal Water Gel™ is an oil and salt tolerant blend using hydrophobic-inclusive cyclodextrins and electrolyte-tolerant polymers that greatly increases the water solubility and stability of incompatible drugs. Ideal for formulas containing higher levels of oils, botanical ingredients, or poorly soluble actives. It provides improvements in solubility, increase in speed of dissolution, together with physical and chemical stability.

UNIVERSAL WATER GEL™ BENEFITS:• API compatibility – hydrophilic & lipophilic• Excellent electrolyte tolerance• Bioavailability enhancement• Improves active stabilization & compatibility• Highly stable across a broad pH range• Masks the odor of unpleasant actives • Cosmetically elegant• Contains alcohol

VERSATILE TOPICAL BASE

Item No. NDC No. Size Price6017-56 00395-6017-56 500 g $21.00 6017-57 00395-6017-57 4.5 kg $165.00

UNIVERSAL WATER GEL™ PROPERTIES

pH 7.0

Specific Gravity 0.95

Viscosity 750,000 cps

Physical Format Gel

Color Translucent

Transdermal Penetration +

API CompatibilityHydrophilic & Lipophilic Total API Load - less than 10%

Typical Applications• Dermatology • Pain Management • Diabetes & Wound Care

Pain Management:Diclofenac 3%Lidocaine 5%Ethoxy Diglycol 8%Universal Water Gel qs 100%

SAMPLE FORMULAS: Hormone Therapy:Testosterone 10%Alcohol 10%Universal Water Gel qs 100%

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Emulsion Concentrate™ is a pH and salt-tolerant emulsifier/hydrocolloid blend that greatly increases emulsification, stability, and thickness of broken emulsions, and separated and thin formulations. It quickly forms emulsions that are fresh, elegant, fast-absorbing, and non-greasy. EMULSION CONCENTRATE™ BENEFITS:• Ready-to-use polymer in fluid form• API compatibility – virtually all APIs• Elegant sensory profile • Low & high temperature resistant (-5º C – 80º C)• Ingredient compatibility • Broad range of applications

VISCOCITY ENHANCER

EMULSION CONCENTRATE™

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Compounding Enhancer

Item No. NDC No. Size Price6016-94 00395-6016-94 4 oz $35.00 6016-98 00395-6016-98 8 oz $57.00

EMULSION CONCENTRATE™ PROPERTIES

pH 4.5 - 6.5

Viscosity 75,000 cps

Physical Format Viscous Gel

Color Opaque

Intended Use

• Emulsify all types of oily phases• Stabilize mineral additives• Thicken in adverse conditions – very acidic or very alka-line, oxidizing• Develop fresh formulas that melt on contact with the skin

API Compatibility Virtually all APIs

pH Compatibility 2.0 - 12.0

Salt Tolerance Salt Forms – 35%

Solvent Compatibility Polar & Non-Polar

Temperature Stability Low & High Temperatures

DIFFERENT VISCOSITIES ARE ACHIEVED BY VARYING THE AMOUNT OF EMULSION CONCENTRATE:

3% FOR LOTIONS 5% FOR CREAMS

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Compounding Concentrates

PRE-MIXED HORMONES IN A BASE

HORMONE CONCENTRATE PROGRAM

For RX Compounding Only

Humco's Hormone Concentrate Program (HCP) is an innovative hor-mone compounding solution that offers convenience, time-savings, and cost-savings. It reduces the number of steps compounding takes, such as weighing out hormone powders; and with fewer opportunities for error, it also improves the accuracy of compounded hormones. Compound-ers are also supplied with a hormone aliquot calculator to easily and quickly calculate formulas. For pharmacists concerned about worker protection, HCP can help reduce the risk of handling hormone powders while also acting as an aid in a pharmacy's required risk assessment. Hormone Concentration Program BENEFITS:• Reduce the risk in handling hazardous drugs • Extended BUD• Free Hormone Aliquot Calculator • Speed, ease and effectiveness in the compounding process• Saves time and trouble • Decreases the chance of compounding errors • All concentrates are in a transdermal hormone base

HORMONE CONCENTRATES

Physical Format Cream

Color White

Typical Applications • Hormone Replacement Therapy

Estradiol Hemihydrate, USP (Micronized) 10% Concentrate Item No. NDC No. Size 6540-62 00395-6540-62 100 g 6540-56 00395-6540-56 500 g

Estriol, USP (Micronized) 10% Concentrate Item No. NDC No. Size 6550-19 00395-6550-19 25 g 6550-62 00395-6550-62 100 g

Progesterone, USP (Micronized) 40% Concentrate

Testosterone, USP (Micronized) 20% Concentrate CIII

Item No. NDC No. Size 6500-62 00395-6500-62 100 g 6500-56 00395-6500-56 500 g

Item No. NDC No. Size 6520-62 00395-6520-62 100 g 6520-56 00395-6520-56 500 g

Humco's HCP was featured in an article from IJPC's January/February 2017 issue entitled "Basics of Compounding with Dilutions and

Concentrates" (pgs. 40-45)

HCP reduces suspended particulates

as seen in the Peer Reviewed

study "Trace Level Analysis of

Airborne Hormone Particulates"

published in IJPC's May/June 2018

issue (pgs. 81-87)

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Compounding Dilutions

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LEVOTHYROXINE (T4) AND LIOTHYRONINE (T3) SODIUM, USP1:1000 DILUTIONSLevothyroxine (T4) and Liothyronine (T3) are administered to patients in very small microgram doses for the treatment of hypothyroidism. Phar-macists must use an aliquot dilution technique to accurately and precisely provide these microgram doses to the patients. The process for making dilutions is very long and arduous, taking hours to appropriately calculate and mix (and this does not include the time or money spent for testing once the dilutions are made). Humco is now manufacturing dilutions of 1:1000 (or 1mg/1gm) for both T4 and T3 for your compounding conve-nience. T4 and T3 Dilution BENEFITS:• Lactose-free• Made in a cGMP compliant, FDA registered facility• Rigorously tested for homogeneity and stability• Speed, ease and effectiveness in the compounding process• Saves time and trouble; no more painstaking geometric dilution process• Decreases the chance of compounding errors

LEVOTHYROXINE (T4) AND LIOTHYRONINE (T3) SODIUM, USP 1:1000 DILUTION PROPERTIES

Physical Format Powder

Color Off White/White

Typical Applications • Thyroid Hormone Replacement

Capsule size 1 is

recommended for a sustained release formula

Please Note: Versatile compounding option for most sustained release or immediate release formulations. For formulations specifying Liothyronine, use the salt conversion of 1.035 mg Liothyronine Sodium to 1 mg of Liothyronine

Item No. NDC No. Size Price6570-19 00395-6570-19 25 g $80.00 6570-62 00395-6570-62 100 g $285.00 6570-56 00395-6570-56 500 g $1040.00

Item No. NDC No. Size Price6560-19 00395-6560-19 25 g $90.00 6560-62 00395-6560-62 100 g $345.00 6560-56 00395-6560-56 500 g $1290.00

For RX Compounding Only

Levothyroxine (T4) Sodium, USP Dilution

Liothyronine (T3) Sodium, USP Dilution

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FLAVOR SWEET™Oral Vehicles

Flavor Sweet™ is a cherry-flavored syrup vehicle formulated to simplify the preparation of oral extemporaneous delivery systems. It may be used alone or in conjunction with other agents to give flavor and sweetness while increasing the suspension’s physical stability. Flavor Sweet™ contains suitable preservatives and is buffered to a slightly acidic pH to provide a dependable and consistent vehicle. • Pink colored, cherry flavored syrup• pH 4.5 – pH 5.0• Recommended use – hydrophilic, acid-stable & hydrophobic actives

SYRUP VEHICLE

Item No. NDC No. Size Price0090-16 00395-0090-16 16 oz $12.25 0090-28 00395-0090-28 1 gal $80.00

FLAVOR PLUS™SUSPENDING VEHICLE

FLAVOR SWEET-SF™Flavor Sweet SF™ is a sugar-free and alcohol-free cherry flavored syrup. It may be used alone or in conjunction with other agents to give flavor and sweetness while increasing the suspension’s physical stability. Flavor Sweet SF™ contains suitable preservatives and is buffered to a slightly acidic pH to provide a dependable and consistent vehicle. • Pink colored, cherry flavored, sugar-free syrup• pH 4.5 – pH 5.0• Recommended use – hydrophilic, acid-stable & hydrophobic actives• Ideal for diabetic preparations

SUGAR-FREE SYRUP VEHICLEItem No. NDC No. Size Price0094-16 00395-0094-16 16 oz $12.25 0094-28 00395-0094-28 1 gal $80.00

Flavor Plus™ is a unique flavor-free, aqueous based suspending vehicle used to simplify the process of compounding oral non-soluble suspensions. It is buffered to an acidic pH providing a uniform, consistent and stable vehicle.• Flavor-free, white liquid suspension• pH 3.5 – pH 4.0• Recommended use – hydrophilic, acid-stable & hydrophobic actives• Ideal for diabetic preparations

FLAVOR BLEND™ALL-IN-ONE SYRUP/SUSPENDING VEHICLEFlavor Blend™ is a uniquely formulated flavored oral suspending vehicle designed to simplify the extemporaneous compounding process of oral suspensions. It combines the flavoring agents of Flavor Sweet™ and the suspending agents of Flavor Plus™, along with preser-vatives and an anti-foam agent to provide an easy preparation of smooth, elegant oral suspensions. • Easy to use• Light pink liquid blend with a cherry flavor• pH 4.5 – pH 5.0• Recommended use – hydrophilic, acid-stable & hydrophobic actives• Incorporate virtually all medicated powders or crushed tablets• Ideal for pediatric & geriatric preparations

Item No. NDC No. Size Price0091-16 00395-0091-16 16 oz $12.25 0091-28 00395-0091-28 1 gal $80.00

Item No. NDC No. Size Price0089-16 00395-0089-16 16 oz $12.25 0089-28 00395-0089-28 1 gal $80.00

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Oral Vehicles

VERSA FREE™

Versa Free™ is a dye-free, flavor-free, paraben-free, sugar-free, gluten-free and saccharin-free syrup vehicle resulting in fewer patient allergic reactions. Virtually no aftertaste.• Flavor-free clear liquid syrup• pH 4.5 – pH 5.0• Natural ingredients & natural preservatives• Recommended use – hydrophilic, acid-stable & hydrophobic actives• Ideal for diabetic, autistic, & allergy-sensitive patients• Soy & gluten-free

DYE-FREE, CHEMICAL-FREE, AND SUGAR-FREE SYRUP VEHICLE

Item No. NDC No. Size Price0125-16 00395-0125-16 16 oz $16.50 0125-28 00395-0125-28 1 gal $85.00

VERSA PLUS™DYE-FREE, CHEMICAL-FREE, AND SUGAR-FREE SUSPENDING VEHICLEVersa Plus™ is a dye-free, flavor-free, paraben-free, sugar-free, gluten-free and saccharin-free suspension vehicle resulting in fewer patient allergic reactions. Virtually no aftertaste.• Flavor-free white liquid suspension• pH 3.5 – pH 4.0• Natural ingredients & natural preservatives• Recommended use – hydrophilic, acid-stable & hydrophobic actives• Ideal for diabetic, autistic, & allergy-sensitive patients• Soy & gluten-free

Item No. NDC No. Size Price0126-16 00395-0126-16 16 oz $16.50 0126-28 00395-0126-28 1 gal $85.00

FIXED OIL SUSPENSIONSUSPENDING VEHICLEFixed Oil Suspension is a natural, nonvolatile oil with suspending properties that easily incorporates lipophilic and many hydrophilic APIs. Fixed Oil Sus-pension may be used to compound sublingual drops and can be used as a topical or cosmetic agent. Fixed Oil Suspension is dye-free, flavor-free, sugar-free, paraben-free, dairy-free, lactose-free, gluten-free, alcohol-free, casein-free, and hexane-free.• Anhydrous• Ordorless and tasteless• 180 days BUD• Recommended use – veterinary, pediatrics, HRT• Oil miscible flavor and sweetener may be added during compounding

Item No. NDC No. Size Price2080-16 00395-2080-16 16 oz $48.50 2080-28 00395-2080-28 1 gal $312.00

BULK PRICING AVAILABLE - Call for more details

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ADDITIONAL ORAL VEHICLES

Oral Vehicles

CHERRY SYRUP Recommended Use: Ionic & Hydrophilic Actives

Item No. Size Price 2662-16 16 oz $12.002662-28 1 gal $65.00

RASPBERRY SYRUPRecommended Use: Ionic & Hydrophilic Actives

Item No. Size Price 2664-16 16 oz $14.25

SIMPLE SYRUP Recommended Use: Ionic & Hydrophilic Actives

Item No. Size Price 2662-16 16 oz $12.002662-28 1 gal $65.002661-75 5 gal $180.00

SORBITOL SOLUTION70%, USPRecommended Use: Ionic & Hydrophilic Actives, Diabetic Additives

Item No. Size Price 3913-16 16 oz $6.50

SYRPALTA (RED)Recommended Use: Ionic & Hydrophilic Actives

Item No. Size Price 3920-16 16 oz $16.00

SYRPALTA (WITHOUT COLOR)Recommended Use: Ionic & Hydrophilic Actives

Item No. Size Price 3927-16 16 oz $16.00

Product Ordering Information

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Miscellaneous Ingredients

ADDITIONAL COMPOUNDING INGREDIENTS

* To purchase this item you must have a DEA license on file

Product Ordering Information Ordering InformationProductACETONE CP Item No. Size

0019-94 4 oz 0019-16 16 oz 0019-28 1 gallon

ALCOHOL, ISOPROPYL 70% USP

Item No. Size 1249-16 16 oz 1249-28 1 gallon

ALCOHOL, ISOPROPYL 99% USP

Item No. Size 1243-16 16 oz 1243-28 1 gallon

ALMOND OIL SWEET, NF Item No. Size 1907-91 1 oz 1907-16 16 oz 1907-28 1 gallon

ARNICA TINCTURE Item No. Size 0115-94 4 oz

ASCORBIC ACID GRANULAR, USP

Item No. Size 0123-94 4 oz

BARIUM SULFATE POWDER, USP

Item No. Size 0200-01 1 lb

BENZOIN COMPOUND TINCTURE, USP

Item No. Size 0243-92 2 oz 0243-16 16 oz

BORIC ACID GRANULAR, NF Item No. Size 0300-94 4 oz 0300-01 1 lb

CALCIUM CARBONATEPOWDER

Item No. Size 0431-01 1 lb

CAMPHOR GUM BLOCKS Item No. Size 0455-91 16-1 oz

CITRIC ACID GRANULAR, USP

Item No. Size 0605-94 4 oz 0605-01 1 lb

COAL TAR TOPICAL SOLUTION, USP

Item No. Size 0617-16 16 oz

GLYCERIN, USP Item No. Size 1031-96 6 oz 1031-16 16 oz 1031-28 1 gallon

GREEN SOAP TINCTURE, USP

Item No. Size 1049-94 4 oz 1049-16 16 oz 1049-28 1 gallon

IODINE TINCTURE MILD 2%, USP

Item No. Size 1213-91 1 oz 1213-16 16 oz

MAGNESIUM CARBONATE BLOCKS

Item No. Size 1601-92 8-2 oz

MENTHOL CRYSTALS, USP Item No. Size 1619-94 4 oz

METHYL SALICYLATE, NF Item No. Size 1667-92 2 oz 1667-16 16 oz

MILK OF MAGNESIA, USP Item No. Size 1670-16 16 oz

MINERAL OIL LIGHT, USP Item No. Size 1673-28 1 gallon

MINERAL OIL HEAVY, USP Item No. Size 1685-28 1 gallon

PERUVIAN BALSAM Item No. Size 2255-94 4 oz

POLYETHYLENE GLYCOL 300, NF

Item No. Size 2335-75 5 gallon

PROPYLENE GLYCOL, USP Item No. Size 2327-28 1 gallon

SALICYLIC ACID POWDER, USP

Item No. Size 2625-94 4 oz 2625-01 1 lb

SODIUM BICARBONATE POWDER, USP

Item No. Size 2685-94 4 oz 2685-01 1 lb

SODIUM PERBORATE GRANULAR TECHNICAL

Item No. Size 2709-94 4 oz 2709-01 1 lb

STRONG IODINE SOLUTION (LUGOL'S)*

Item No. Size 2775-16 16 oz

SULFUR POWDER, USP Item No. Size 2799-94 4 oz 2799-12 12 oz

ZINC OXIDE POWDER, USP Item No. Size 3501-01 1 lb

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Humco Natural

Therapies

Essential Oils100% Pure, 100% Natural

Roll-Ons Pure Essential Oils Diluted with Sunflower Seed and Avacado Oils

Roll-Ons make essential oil application easy. Each essential oil is prediluted with sunflower seed and avacado oils, making it ideal for skin application. Each Roll-On also comes complete with unique application points to take the guess work out of aromatherapy.

100% pure, undiluted essential oils for use in aromatherapy, skin care, hair care, home remedies, and more.

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Humco Natural

TherapiesMoisturizing Sprays100% Natural Hydrosol Waters

• Created during the steam distillation process of essential oils

• Hydrates and refreshes skin by locking in the needed moisture we lose every day

• 2-in-One Facial Primer and Setting Spray

• Hydrates and adds shine to hair. Simply spray onto damp hair after a shower to control fly-aways and frizz and to give hair a sleek, natural shine.

Siberian Pine Essential OilItem No. UPC No. Size 2036-44 303952036449 2 oz

Sweet Orange Essential OilItem No. UPC No. Size 2003-44 303952003441 2 oz

Sweet Almond Carrier OilItem No. UPC No. Size 1907-44 303951907443 2 oz

Tangerine Essential OilItem No. UPC No. Size 2039-44 303952039440 2 oz

Lemon Essential OilItem No. UPC No. Size 2040-44 303952040446 2 oz

Lemongrass Essential OilItem No. UPC No. Size 2031-44 303952031444 2 oz

Lime Essential OilItem No. UPC No. Size 2037-44 303952037446 2 oz

Peppermint Essential OilItem No. UPC No. Size 2015-44 303952015444 2 oz

Grapefruit Essential OilItem No. UPC No. Size 2027-44 303952027447 2 oz

Lavender Essential OilItem No. UPC No. Size 1979-44 303951979440 2 oz

Anise Essential OilItem No. UPC No. Size 1913-44 303951913444 2 oz

Cedarwood Essential OilItem No. UPC No. Size 2034-44 303952034445 2 oz

Cinnamon Essential OilItem No. UPC No. Size 1937-44 303951937440 2 oz

Citronella Essential OilItem No. UPC No. Size 1943-44 303951943441 2 oz

Clove Essential OilItem No. UPC No. Size 1949-44 303951949443 2 oz

Eucalyptus Essential OilItem No. UPC No. Size 1973-44 303951973448 2 oz

Tea Tree Essential OilItem No. UPC No. Size 4817-44 303954817442 2 oz

Peppermint Moisturizing SprayItem No. UPC No. Size 2026-78 303952026785 2 oz

Lavender Essential Oil Roll-OnItem No. UPC No. Size 1979-33 303951979334 2 oz

Tea Tree Essential Oil Roll-OnItem No. UPC No. Size 4817-33 303954817336 2 oz

Peppermint Essential Oil Roll-OnItem No. UPC No. Size 2035-33 303952035336 2 oz

Lavender Moistuizing SprayItem No. UPC No. Size 1979-78 303951979785 2 oz

Rosemary Moisturizing SprayItem No. UPC No. Size 2021-78 303952021780 2 oz

Lemongrass Moisturizing SprayItem No. UPC No. Size 2024-78 303952024781 2 oz

Rosemary Essential Oil Roll-OnItem No. UPC No. Size 2021-33 303952021339 2 oz

Lemongrass Essential Oil Roll-OnItem No. UPC No. Size 2024-33 303952024330 2 oz

Rose Geranium Moisturizing SprayItem No. UPC No. Size 2025-78 303952025788 2 oz

Grapefruit Essential Oil Roll-OnItem No. UPC No. Size 2032-33 303952032335 2 oz

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HUMCO GLOBAL HEADQUARTERS201 West 5th Street Suite 1250Austin, TX 78701

+1 (855) 925-4736 www.Humco.com


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