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Profert Male

POTENT NUTRIENTS AND ANTIOXIDANTS FOR OPTIMUM SPERM HEALTH

The role of nutraceuticals as vitamins , minerals and antioxidants is very well documented and

accepted in Male Infertility , resulting in Enhance male fertility with regard to higher semen volumes,

sperm concentrations, the percentage of normal sperm morphology and sperm motility in male

partners of sub-fertile couples with idiopathic infertility.

Reactive oxygen species, such as

superoxide anion and hydrogen

peroxide, are known to impair sperm

motility and membrane integrity by

inducing membrane lipid peroxidation

(LPO). Infertile men have higher levels

of semen reactive oxygen species

(ROS) than do fertile men.

High levels of semen ROS can cause

sperm dysfunction, sperm DNA

damage and reduced male

reproductive potential. This observation has led clinicians to treat infertile men with antioxidant

supplements.

To date, most clinical studies suggest that dietary antioxidant supplements are beneficial in terms of

improving sperm function and DNA integrity. The improvement of clinical symptoms, as sperm

indexes (semen liquefied duration, motility, viability, density and abnormal morphology is seen by

giving nutritional and antioxidant support.

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Semen Analysis

Male factor infertility is assessed based upon the following values:

(1) Deficient sperm count (less than 10 million per milliliter; volume should be 1 - 5 ml. of

ejaculate)

(2) Insufficient sperm motility (over 60% should be motile and demonstrate purposeful forward

movement), and/or (3) poor sperm morphology (more than 50-60% abnormal in form)

Infertility is defined as the inability to fertilize the ovum; whereas sterility is defined as the lack

of sperm production.

The average ejaculate sample contains almost 200 million sperm. Amazingly enough, only a few

dozen sperm actually reach the egg for a chance at penetration. This makes for some pretty

ominous statistics for sperm overall. It is for this reason that sperm numbers must be so high,

just to have a modicum of hope of reaching the vicinity

of the egg traveling down the fallopian tube. If both

partners have fertility issues, it seems truly a miracle

that conception ever even takes place. Luckily, there are

methods to improve sperm count, motility, and

morphology.

An Overview of Sperm Production

Sperm production begins during puberty in response to

the same hormones (LH and FSH) as in the female. But

the LH signals cells within the leydig cells of the testes to

produce testosterone, and FSH signals sertoli cells to produce sperm. Estrogen is also important

in sperm formation, but too much dietary

synthetic sources of estrogen can be harmful.

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The seminal vesicles secrete substances which nourish the sperm, including fructose (which

feeds the sperm), fibrinogen (which holds or coagulates the fluid together) and prostaglandins

(which help the sperm penetrate the cervix). The prostate adds an alkaline fluid to the

ejaculate. It is extremely important to keep the sperm in a more alkaline environment because

the vaginal pH is relatively acidic.

Seminal fluid in normal, fertile men contains antioxidant factors. In many sub fertile men the

seminal fluid may not contain the protective elements or the

circulating free radicals may be so abundant that the seminal

fluid is not capable of scavenging the damaged reactive oxygen

species. Therefore, men with suboptimum sperm counts

should include dietary sources of antioxidants.

The plasma membrane of human sperm contains high levels of

polyunsaturated fatty acids, making them extremely

susceptible to peroxidative changes. Free radical damage leads

to functional impairment in the sperm, lowering motility and

morphology.

Most vaginal lubricants are hostile to sperm. The only vaginal

lubricants which have been found to support sperm longevity

are egg whites (yes, really) and canola oil.

Male reproductive potential and lifestyle factors :

Infection: The role of infection in idiopathic male infertility has

been underestimated, in particular chronic asymptomatic

chlamydial infections.1 Chlamydia can reside in the epididymis

and vas deferens, affecting sperm development and fertility.

One study suggests approximately 28-71 percent of infertile

men have evidence of a chlamydial infection. The presence of

anti-sperm antibodies may indicate an undiagnosed infection,

and is estimated to be a relative cause of infertility in 3-7 percent of cases. In a study designed

to examine the effects of antioxidants on anti-sperm antibodies, there was a significant

correlation between beta carotene levels and antibody titers, suggesting dietary antioxidants

are involved in mediating immune function in the male reproductive system.

Potential Contributing

Factors in Male Infertility

Infection

Hormonal imbalances

Hepatic cirrhosis

Infection

Excessive heat

Radiation exposure

Heavy metal toxicity

Cigarette smoking & Alcohol

Obesity

Xeno-estrogen exposure

Pesticide exposure

High intake of cottonseed

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Declining Sperm Counts There is a growing body of scientific evidence supporting the idea that sperm counts have

declined considerably over the last 50 years. Carlsen et al analyzed a total of 61 studies

including 14,947 men from the years 1938 to 1991, for mean sperm density and mean seminal

volume. Their results show a significant decline in mean sperm density from 113 million/ml in

1940 to 66 million/ml in 1990. (p<0.0001). Seminal volume decreased from an average of 3.40

ml to 2.75 ml (p=0.027).6,7 .This demonstrates a 20-percent drop in volume and a substantial

58-percent decline in sperm production in the

last 50 years. Three other recent reports also

found semen quality has declined among

donors over the last 20 years.8-10 Because

the decline in sperm production is relatively

recent, one must suspect a combination of

environmental, lifestyle, and dietary factors

might be interfering with spermatogenesis.

Environmental Risk Factors:

Current evidence suggests there may be environmental reasons for deteriorating sperm quality, including occupational exposure to various chemicals, heat, radiation, and heavy metals. In addition, exposure to environmental estrogens and pesticides has been linked to alterations in spermatogenesis. Lifestyle risk factors are also significant, including cigarette smoking, alcohol consumption, chronic stress, and nutritional deficiencies. Xeno-Estrogens and Pesticides Increased exposure to estrogens is thought to be responsible for not only prenatal testicular

damage, but may also contribute to post-natal depression of testicular function and

spermatogenesis. Exogenous estrogens impact fetal development by inhibiting the

development of Sertoli cells, which determine the lifelong capacity for sperm production.

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Circulating estrogens also inhibit enzymes involved in testosterone synthesis and may directly

affect testosterone production.

The synthetic estrogen, diethylstilbestrol (DES), is a well-documented example of this problem.

DES was prescribed from 1945 to 1971 to millions of women during pregnancy. Male offspring

from those women had a higher incidence of developmental problems of the reproductive

tract, as well as diminished sperm volume and sperm count.

Synthetic estrogens are still widely used in the livestock, poultry, and dairy industries. Men

wishing to improve their fertility and sperm quality probably should avoid hormone-containing

dairy products and meats and opt instead for organic or hormone-free foods.

Many commonly-used pesticides, such as organochloride compounds, have estrogenic effects

within the body. Chemicals such as dioxin, DDT, and PCBs are known to interfere with

spermatogenesis. One study which examined the effect of DDT on male rat sexual development

found low levels of DDT caused degeneration in sperm production, a decrease in the total

number of sperm, and a reduced number of Leydig cells. DDT acts as an hormonal disrupter,

damaging the seminiferous epithelium and lowering local testosterone levels.

Dietary and Lifestyle Factors In addition to avoiding exogenous estrogens and pesticides, there are other dietary factors to

consider. Adequate intake of essential fatty acids is important to ensure proper membrane

fluidity and energy production in sperm cells. High dietary intake of hydrogenated oils,

particularly cottonseed oil, has been shown to have a negative impact on sperm cell function.

Not only does cottonseed oil contain toxic pesticide residues, it also contains high levels of the

chemical gossypol, which can interfere with spermatogenesis.

In Nigeria, a randomized, controlled trial was designed to evaluate the effect of dietary

aflatoxin on infertile men. Forty percent of the 50 infertile men in the study had aflatoxin in

their semen samples, compared to eight percent of the fertile control group. Infertile men

exposed to dietary aflatoxin had a 50-percent higher number of abnormal sperm.

Heavy Metals Numerous environmental pollutants have been linked with testicular oxidative stress. Among these are air pollutants such as diesel particulate matter. Cadmium and lead have been specifically linked with sperm oxidative damage; mercury and arsenic are also toxic to sperm [33]. The male reproductive system is also adversely affected by agricultural pesticides and industrial chemicals, and illustrates the importance of recording potential occupational exposures in the clinical history. Hyperthermia, whether from tight clothing or from working in a continuous sedentary position (e.g., truck driving, computer work), has also been implicated

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in the production of elevated levels of ROS and RNS, since germinal cells respond to increased temperature by production of heat-shock proteins. Cigarette Smoking Cigarette smoking has been associated with decreased sperm count, alterations in motility, and an overall increase in the number of abnormal sperm. A study designed to evaluate seminal zinc levels in smokers and non-smokers found that although smokers did not have significantly lower zinc levels than non-smokers, seminal cadmium levels were significantly increased, especially in those smoking more than one pack per day. Experimental evidence also Suggests nicotine can alter the function of the hypothalamic-pituitary axis, affecting Growth hormone, cortisol, vasopressin, and oxytocin release, which then inhibits the Release of luteinizing hormone (LH) and prolactin.21 Cigarette smokers were also shown to have higher levels of circulating estradiol and decreased levels of LH, follicle stimulating hormone (FSH), and prolactin than non-smokers, all of which potentially impact spermatogenesis. Smokers with low prolactin levels also demonstrated defects in sperm motility.

Alcohol

Excessive consumption of alcohol increases ROS levels and many alcohol abusers consume

insufficient dietary amounts of protective antioxidants. Dietary deficiencies have been linked to

oxidative damage in spermatozoa.

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Extreme Exercise :

Extremes of exercise have also been linked with oxidative stress . Muscle-aerobic metabolism is

the cause of ROS in those who exercise regularly . ROS therefore may be heightened in those

employed in strenuous occupations where physical exertion is routine (i.e., agricultural

workers, day laborers, construction, etc).

Obesity :

Among the obese, adipose tissue releases pro-inflammatory cytokines that increase leukocyte

production of ROS . Several recent population-based studies have shown an increased

likelihood of abnormal semen parameters among obese men .The increasing worldwide

prevalence of obesity is of concern to all medical professionals, especially as it is a risk factor for

Type II diabetes mellitus. Hyperglycemia increases ROS and adversely affects spermatic

parameters.

Medications :

Several medications, chemotherapeutic agents, antimicrobials, and radiation may affect

gonadal function and can possibly result in azoospermia . Cannabis, heroin, and cocaine

adversely affect spermatic parameters, but the extent to which they do so is dependent upon

the quantity and frequency of use [.

Aging & Stress:

Sperm DNA damage increases with advancing age in both fertile and infertile men, possibly

because of normal increases in ROS levels over time [. Psychological stress reduces semen

quality with a central underlying mechanism being impairment of gonadotropin drive . Stress

also reduces sperm quality by increasing plasma ROS generation and decreasing antioxidant

protection .

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Dietary Vitamins & antioxidants Minerals : Carotenoids , Vitamin C , E ,B complex , Zinc and

selenium have well documented role as antioxidants in protecting oxidation induced damage to

spermatozoa. Outcome of Numerous clinical studies have proven the beneficial role of these

dietary nutrients in improving fertility and protecting spermatozoa from oxidative damage.

Tribulus terrestris L. extract, : A non-hormonal plant-derived extract, has been successfully

used in Europe and Asia to treat sexual dysfunctions. Active components of this extract were

determined to be a furostanol saponin, named protodioscin. Oral administration of this extract

to laboratory animals resulted in the stimulation of spermatogenesis and the proliferation of

the spermatogonia, which involved cell divisions of the spermatocytes and spermatids. In

addition to the increased mitotic activity of the spermatozoa and the increased number of

Sertoli cells, sperm viability and survival were also significantly increased. Detailed clinical trials

found that protodioscin was not toxic and had no undesirable side-effects.

Protodioscin, a furostanol saponin as the active ingredient has beneficial effects on the

improvement of spermatogenesis, and on the increase in sperm mobility. Tribulus terrestris L.

treatment has clinically positive effect on sperm morphology and acrosome reactions in

subjects with oligoasthenoteratozoospermia.

Mucuna Prureins Extract : M. pruriens seed powder not only reactivates the enzymatic activity

of metabolic pathways and energy metabolism but also rejuvenates the harmonic balance of

male reproductive hormones in infertile men. These findings open more opportunities for

infertility treatment and management by improving semen quality. Treatment with M. pruriens

regulates steroidogenesis and improves semen quality in infertile men.

Withania Somnifera Extract : It inhibited lipid peroxidation and protein carbonyl content and

improved sperm count and motility. Treatment of infertile men recovered the seminal plasma

levels of antioxidant enzymes and vitamins A, C, and E and corrected fructose. Moreover,

treatment also significantly increased serum T and LH and reduced the levels of FSH and PRL.

The treatment with W. somnifera effectively reduced oxidative stress, as assessed by decreased levels of various oxidants and improved level of diverse antioxidants. Moreover, the levels of T, LH, FSH and PRL, good indicators of semen quality, were also reversed in infertile subjects after treatment with the herbal preparation.

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Lycopene : Lycopene seems to have a role in the management of idiopathic male infertility. In

a trial with lycopene patients (66%) showed an improvement in sperm concentration, (53%)

had improved motility and fourteen (46%) showed improvement in sperm morphology .

Co Q 10 : Three-month supplementation with CoQ10 in OAT infertile men can attenuate oxidative stress in seminal plasma and improve semen parameters and antioxidant enzymes activity. Coenzyme Q10 supplementation results significant improvement in certain semen parameters. Elevated seminal plasma CoQ10 levels are associated directly with good semen parameters and inversely with the oxidative stress.

L-carnitine :L-carnitine, capable of significantly improving sperm motility and raising the rate of

pregnancy, is a safe and effective therapeutic option for asthenozoospermia.

Indications: Profert Male is useful in Azospermia , Oligospermia & Decrease motility leading to male

infertility

Dosage: ADULTS: The recommended dosage 1-2 capsules a day.

Profert Male should be taken for 2-6 months or even more to have the desired sperm health. Its use is

found to be safe and can be used regularly as a male health supplement. When used as a fertility

supplement use of loose undergarments and garments are recommended to avoid pressure on testis.

Precautions :None

Pack Size: 10 capsules ( strip) x 2 per Box

For further Details Please Write to Product Management AHL Herbal Pharma .

Full Prescribing Information is available on request.

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Profert Forte

SUPPLEMENT FACTS

Mixed carotenoids : 10 mg

Vitamin C : 50 mg

Vitamin E : 10 mg

Thiamine B1 :1.4 mg

Riboflavine B2 : 2.2 mg

Niacin B3 : 18 mg

Pyridoxin B6 : 2 mg

Panthonic Acid : 60 mg

Follic Acid : 400 mcg

B 12 : 2 mcg

Zinc as Gluconate : 20 mg

Selenium : 50 mcg

Saffron : 2 mg

Piper Longum Extract : 30 mg

Ginseng Extract : 50 mg

Tribulus Terrestris Extr : 200 mg

Gingko Biloba Extract : 40 mg

curculigo orchioides : 50 mg

Chlorophytum borivilianum Ext: :50 mg

Mucuna Prureins Ext : 50 mg

Withania Somnifera Ext : 50 mg

L Arginine : 50 mg

Lycopene : 10 mg

Co Q 10 : 20 mg

L-carnitine : 100 mg

Profert

SUPPLEMENT FACTS

Mixed carotenoids : 10 mg

Vitamin C : 50 mg

Vitamin E : 10 mg

Thiamine B1 :1.4 mg

Riboflavine B2 : 2.2 mg

Niacin B3 : 18 mg

Pyridoxin B6 : 2 mg

Panthonic Acid : 60 mg

Follic Acid : 400 mcg

Zinc as Gluconate : 20 mg

Selenium : 50 mcg

Saffron : 2 mg

Piper Longum Extract : 30 mg

Ginseng Extract : 50 mg

Tribulus Terrestris Extr : 200 mg

Gingko Biloba Extract : 40 mg

curculigo orchioides : 50 mg

Chlorophytum borivilianum Ext: :50 mg

Mucuna Prureins Ext : 50 mg

Withania Somnifera Ext : 50 mg

L Arginine : 50 mg

Lycopene : 10 mg

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