Professor Denis Warwick King OAM · Name: Denis Warwick King ... • Clinical Management Structure...

Curriculum Vitae

Professor Denis Warwick King OAM

Name: Denis Warwick King Address: c/o Sydney Colorectal Associates Ground Floor, Hurstville Private Hospital 37 Gloucester Road Hurstville NSW 2220 Awards: Medal of the Order of Australia in the General Division (2010) Degrees: MB BS Sydney University 1966 FRACS 1970 Current Appointments: Visiting Medical Officer Colorectal Unit St George Hospital Clinical Professor Graduate School of Medicine University of Wollongong

Clinical Associate Professor UNSW Chair Illawarra and Shoalhaven Local Health District Board Chair NSW Health Ministerial Advisory Committee Member Council University of Wollongong

3

Previous Appointments:

1966 Intern, St. George Hospital

1967 Senior Resident Medical Officer

St. George Hospital

1968 Demonstrator

School of Anatomy

University of Sydney

1969-1970 Surgical Registrar

St. George Hospital

1971 Senior Surgical Registrar

St. George Hospital

1972 Lecturer in Surgery

University of Singapore

Singapore General Hospital

1973 Surgical Registrar

Royal Salop Infirmary

Shrewsbury, Shropshire

1974 Commonwealth Registrar

St. George's Hospital, London

Clinical Assistant

St. Mark's Hospital, London

1975 Research Fellow

St. Mark's Hospital, London

1976 Clinical Superintendent

St. George Hospital, Kogarah

1990-1995 Director

Division of Surgery

St George Hospital

2000-2003 Director

Division of Critical Care and Surgery

St George Hospital

2003-2005 Chair, Surgical Stream

South East and Illawarra Health Service

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2000-2008 Strategic Advisory Board

John Curtin School of Medical Research (2000- 08)

2006-2009 Executice Clinical Director

South Eastern Sydney & Illawarra Area Health Service

2007-2010 Chairman, Board, Continuum Health Care

2007-2010 Board of Directors

St George Medical Research Foundation

Membership of Societies:

St. Mark's Association

Surgical Research Society of Australia

Sydney Colorectal Surgical Society (Foundation Member)

Colorectal Surgical Society of Australia (Foundation Member)

Journal Associations:

Member, Consultant Board, International Journal of Colorectal Disease

Reviewer Medical Journal of Australia

Reviewer Diseases of the Colon & Rectum

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Committee Membership:

1986-88 President, Sydney Youth Orchestra Association

1988-89 Chairman, Medical Staff Council, St. George Hospital

Chairman, St. George Hospital Planning Committee

1990 - New South Wales Department of Health Oncology Advisory

Committee

1991-92 Chairman, Cancer Centre Working Party, St. George Hospital

1992 Reid-Harris Committee

1994 - Waiting List and Emergency Department Working Party,

NSW Health

1995 - 96 Clinical Standards Group, Clinical Costing Project

1995 - 96 Member, Reference Group

Member, Implementation Committee

Member, Best Practice Group

Waiting List Implementation Project, NSW Health

2004 – 2006 Member

Surgical Services Task Force

NSW Health

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Health Management:

Director Special Projects (Clinical Services)(1994-96)

Southern Sydney Area Health Service

Director MA International - reviews conducted

• Clinical Management Structure Auckland General Hospital (1995)

• Feasibility study Indonesian National Referral Hospital (for

AusHealth)(1996)

• Surgical Services Alfred Hospital, Melbourne (1997)

• Clinical Services Whyalla Hospital (for South Australian Dept Health)

(1997)

• Surgical Services Geelong Hospital (1998)

• Clinical Services Albury Base Hospital (for Greater Murray Area

Health Service) (1998-99)

• Clinical Services Mid-Western Area Health Service (1999)

• Surgical Services Richmond Valley (for Northern Rivers Area Health

Service (1999)

• Broken Hill Hospital Clinical Services (for Far Western Area Health

Service) (2000)

• ACT Surgical Services (for ACT Health) (2000)

• Review Clinical Services Peel AHS (WA) (2001)

• Review Operating Theatres Nepean Hospital (2001)

• Review Clinical Services Nepean Hospital (with M Gleeson) (2002)

• Review Clinical Services Lithgow Private Hospital (2002)

• Review Surgical Services Royal North Shore and Ryde Hospitals

(2004)

• Development of Clinical Services Plan Northern Sydney and Central

Coast AHS (2008)

• Review of Clinical Engagement in NSW Health Services – NSW Health

(with A McCarroll) (2008)

• Review Perioperative Service Prince Charles Hospital, Brisbane(2008)

• Review Pain Management and Research Service – Royal North Shore

Hospital (2009)

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Presentations at Scientific Meetings/Abstracts:

1. Surgical Research Society of Australasia

Dunedin NZ, 19th September 1987

King D W, Lubowski D Z, Bruck C E. Do patients with haemorrhoids have pelvic floor

denervation?

(Selected by SRSA for presentation at SRS UK meeting, Bristol, July 1987)

2. Sydney Colorectal Surgical Society Scientific Meeting

Orange, 19th March 1988

Lubowski D Z, King D W. What is the best way of measuring external anal sphincter function?


Orange, 19th March 1988

King D W, Lubowski D Z. The relation between utero-vaginal prolapse and pelvic floor

denervation.

4 & 5. Royal Australian College of Surgeons, General Scientific Meeting

Brisbane, 4th May 1988

Lubowski D Z, King D W. Do patients with haemorrhoids have pelvic floor denervation?

Sigmoid strictures at colonoscopy - an indication for surgery.

King D W, Armstrong A, Lubowski D.

6. Royal Australasian College of Surgeons, General Scientific Meeting

Brisbane 4th May 1988

Sigmoid strictures at colonoscopy - an indication for surgery.

7 & 8. American Society of Colon and Rectal Surgeons Meeting

California, 14th June 1988

Lubowski D Z, King D W, Finlay I G. Failure of contraction of pubococcygeus muscle as a cause of

obstructed defaecation.

King D W, Lubowski D L, Bruck C E. Do Patients With Haemorrhoids Have Pelvic Floor

Denervation? (Poster presentation)

9. Surgical Research Society, Tripartite Meeting (UK SRS, European SRS, Society of University

Surgeons),

Bristol, UK, 7th July 1988

Lubowski D Z, King D W, Bruck C E. Do patients with haemorrhoids have pelvic floor

denervation?

10 Royal Australasian College of Surgeons, NSW State Committee ASM

Sydney, 17th September 1988

Beevors M, King D W. Appendicectomy audit.

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11. Sydney Colorectal Surgical Society Annual Scientific Meeting

Sydney 12th November 1988

Staging - why bother?


Sydney, 4th February 1989

Colonoscopy - Changing indications.

13. Royal Australasian College of Surgeons Annual Scientific Meeting

Melbourne, 10th May 1989

Lubowski D Z, King D W. The pelvic floor in obstructed defaecation

14,15,16. American Society of Colon and Rectal Surgeons Annual Scientific Meeting

Toronto, Canada June 1989

King D W, Lubowski D Z. The relationship between utero-vaginal prolapse and pelvic floor

denervation

Lubowski D Z, King D W, Cook T. Should the anal mucosa be removed in restorative

proctocolectomy for ulcerative colitis (poster presentation)

Lubowski D Z, King D W. Colon transit in health and constipation assessed using oral I-131

(poster presentation)

17,18.19. Tripartite Meeting (RSM, ASCRS, RACS)

Birmingham, UK, 20th June 1989

Lubowski D Z, King D W, Cook T A. Should the anal mucosa be removed in restorative

proctocolectomy for ulcerative colitis?

King D W, Lubowski D Z, McLean R, Bruck C E, Tallet N A. Colonic transit time determined by

radionucleotide imaging in patients with constipation.

King D W, Lubowski D Z, Beevors M A, Carlton M A. Pelvic floor function in uterovaginal

prolapse (poster presentation)

20. Royal Australasian College of Surgeons Annual Scientific Meeting

Sydney, 18th August 1990

Lubowski D Z, King D W, McLean R, Smart R, Gaston-Parry D. Colon transit in health and

constipation - analysis of oral In-111 DTPA

Awarded State Committee Medal for Best Fellows Paper at ASM

21,22,23,24. Royal Australasian College of Surgeons General Scientific Meeting

Sydney, 9th May 1991

Lam T, Lubowski D Z, King D W. Posterior pelvic floor repair for obstructed defaecation.

9

Kooner R, King D W, Lubowski D Z. Faecal incontinence - Selection of patients and results of

treatment.

Lam T, Lubowski D L, King D W. Does squatting reduce pelvic floor descent and pelvic nerve

damage?

Morris D L, Dilley A V, Warlters A, Horton M, Clingan P, Tindal D, King D W. Hepatic Cryotherapy

for Metastases - Greater Effect of Twin Freeze/Thaw Cycle

25. St. Mark's Association Meeting

London, 28th June 1991

Lubowski D Z,King D W, McLean R G, Smart R. Oral In-111 DTPA Scintigraphy: its value for

routine clinical assessment of colon transit

26. Academy of Medicine, Silver Jubilee Meeting

Singapore, 9th November 1991

Lubowski D Z, King D W, McLean R G, Smart R, Gaston-Parry D. Oral In-111 DTPA Scintigraphy:

its value for routine clinical assessment of colon transit in severe constipation

27. American Society of Colon and Rectal Surgeons

5th May1993

Meagher AP, Adams WJ, Lubowski DZ, King DW

Autonomic nerves cross the plane of posterior rectal dissection

(poster presentation)


Sydney, 17th July 1993

Topical glyceryl trinitrate in the management of anal fissures.

29,30,31,32,33. Tripartite Colorectal Meeting

Sydney, 17-20th October 1993

King D, Adams W, Meagher A, Lubowski D.

Pretreatment with bisacodyl reduces the volume of polyethylene glycol solution required for

bowel preparation.

Lubowski D, Meagher A, Sun W, King D.

A prospective trial of biofeedback vs placebo for the treatment of anismus

Lubowski D, Meagher A, King D, Smart R, Butler P.

A scintigraphic study of colonic function during defaecation.(poster presentation)

Adams W, Meagher A, Lubowski D, King D.

Autonomic nerves cross the plane of posterior rectal dissection.(poster presentation)

Lubowski D, Meagher A, King D.

Physiological measurement of external sphincter pressure: To squeeze or cough?

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Lubowski D, Meagher A, King D. (poster presentation)

34.British Society of Gastroenterology Scientific Meeting

Manchester 23rd-24th March 1994

Adams W, King D, Lubowski, Morris DL.

Cimetidine prevents postoperative Suppression of Immune Function Following Colorectal

Cancer Surgery

35,36,37 Royal Australasian College of Surgeons Annual Scientific Meeting

Hobart 1st-6th May 1994

Young C, King D, Lubowski D, Jorgensen J

Oral Sodium Phosphate Solution is a Superior Preparation to Polyethylene Glycol with Bisacodyl

Kennedy M, Lubowski D, King D

Glyceryl Trinitrate for Anal Fissure

Young C, Kennedy M, Lubowski D, King D

Post-anal Repair for faecal incontinence

38,39,40 Surgical Research Society of Australasia Annual Meeting

St Vincent’s Clinic Sydney August 1994

Kennedy ML, Lubowski DZ, King DW

Chemical Sphincterotomy for Anal Fissure - a new treatment

King J, Dasappa VK, Ross WB, King DW, Clingan P, Morris DL

Survival of Patients with Synchronous Colectomy & Intrahepatic Chemotherapy

Stewart GJ, Preketes AP, Lubowski DZ, King DW, Morris DL

Colorectal Cancer Response to High Dose Sandostatin Therapy: A Clinical Trial

41 Sydney Colorectal Surgical Society

Thredbo, 12-14 August 1994

Chen FC, Kennedy ML, Lubowski DZ, King DW.

Subtotal Colectomy for Slow transit Constipation

42 Sixth National Casemix Conference, Commonwealth Dept of Human Services and Health

Hobart 31 August 1994

King DW, Kidd J, Stahel R

Clinical Budgeting - The St George Experience

43 Australian Gastroenterology Week (Gastroenterological Society Meeting)

Sydney September 1994

Young C, Kennedy ML, Lubowski DZ, King DW

Post-anal repair for Faecal Incontinence - long term results (poster)

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44 ASM NSW State Committee, Royal Australasian College of Surgeons

Pokolbin 10/11 Sep 1994

Young C J, Jorgensen J O, King D W, Lubowski D Z

Oral Sodium Phosphate Solution is a superior Colonoscopy Preparation to Ployethylene Glycol

with Bisacodyl

45 American Society of Colon and Rectal Surgeons, Washington, June 1996

Talley N A, Chen F, King D, Jones M, Talley N J

Short-Chain Fatty Acids in the Treatment of Radiation Proctitis

46. 3rd

Australian peptide Conference – From Discovery to Therapeutics – Oct 1998

Burcher E, Warner FJ, Shang F, Markus I, Lubowski DZ, King DW

Characterisation and autoradiographic localization of tachkynin receptors in human colon

47. Western Pharmacol. Soc., Maui, USA, Feb 1999

Burcher E, Warner FJ, Shang F, Markus I, Liu L, Lubowski DZ, King DW

Tachykinins in human colon

48 American Gastroenterological Association Conference, Atlanta. May 2001

Dinning PG, Bampton PA, Andre J, Kennedy ML, Lubowski DZ, King D, Cook IJ

Constipation due to obstructed defaecation is likely to be a colonic rather than an anorectal

disorder

49 Sydney Colorectal Surgical Society

St George Private Hospital 28Jul01

Preoperative CT: selection of patients for combined colon and liver resection or hepatic artery

chemotherapy

50. GI Motility Symposium; Murdoch Children’s Research Institute; Royal Children’s Hospital,

Melbourne. 20Apr02

Azriel Y, Grimm M. Lubowski D, King D, Burcher E

Neurotensin in idiopathic slow transit constipation

51. GI Motility Symposium; Murdoch Children’s Research Institute; Royal Children’s Hospital,

Melbourne. 20Apr02

Burcher E, Shang F, liu L, Markus I, King D, Lubowski D

Mechanism of tachykinin induced contraction in the human colon

52. American Gastroenterological Association Conference, San Francisco. May 2002

Dinning PG, Bampton PA, Kennedy ML, Lubowski DZ, King D, Cook IJ

Heightened rectal sensory thresholds and blunted recto-colonic motor reflexes implicated in

constipation due to obstructed defaecation

53. AHMR, Melbourne, Dec 2002

Azriel Y, Grimm M. Lubowski D, King D, Burcher E

Alterations in neurotensin receptors and responsiveness in slow transit constipation

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54, 55, 56. Annual Scientific Congress, Royal Australasian College of Surgeons, Brisbane May

2003

Khoo OKS, Kadir A, Balalla B, King DW, Perera DS

Abdominal distension and post colonoscopy pain.

Schmidt LM, Williams P, Khoo OKS, King DW, Perera DS

Oral sodium picosulfate is a superior colonoscopy preparation compared to sodium phosphate

Fernando SC, Haghighi KS, Chu F, King J, King DW, Lubowski DZ, Zhao J, Morris DL

Synchronous approach to liver metastases from colorectal cancer: Longterm survival and

indicators of prognosis after hepatic resection and chemotherapy

57. Australian Gynaecological Endoscopic Surgical Conference 17th

May 2003

Thornton MJ, Lam A, King DW

Laparoscopic or transanal repair of rectocoele? A retrospective matched cohort study.

58, 59. Australian Gastroenterological Society, Cairns 8th

October 2003

Thornton MJ, Kennedy ML, Lubowski DZ, King DW

Vaildation of the high frequency wave form demonstrated in the hypertonic anal sphincter: The

Fast Wave

Thornton MJ, King DW, Lubowski DZ, Cross KM, Glenn D

Assessment of the value of the pre-operative abdominal CT in colorectal cancer

60, 61, 62, 63. American Gastroenterological Society, Baltimore, USA, 13th

October 10-15, 2003


Validation of the high frequency wave form demonstrated in the hypertonic anal sphincter: The

Fast Wave

Journal of Gastroenterology and Hepatology 2003; 18(suppl): A B44


Long-term follow-up of the dynamic graciloplasty reconstruction for faecal incontinence.

Saafan AK, Thornton MJ, Gebski V, Burcher E, Shang F, King DW

The prevalence of diverticular disease in patients with slow transit constipation.


Cosman D, Thornton MJ, Cross KM, King DW, Morris DL

Hepatic metastases from colorectal cancer: analysis of morbidity and mortality of synchronous

treatment

64. Thornton MJ, Cross KM, King DW, Lubowski DZ, Morris DL

Assessment of the value of the preoperative abdominal CT in colorectal cancer


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65, 66, 67. 19th

International Symposium on Gastrointestinal Motility, Barcelona, Spain October

5-8, 2003

Burcher E, Shang F, King D, Lubowski D

Actions of tachykinin and acetylcholine in human taenia coli: changes in disease

Reduction in Neurotensin receptors and neurotensin mediated contractile responses in Slow

Transit Constipation. (poster)

Azriel Y, Burcher E, Grimm M, Lubowski D, King D

The frequency of retrograde colonic propagating sequences may depend on colonic loading.

(poster)

Dinning P, Cook I, Bampton P, Lubowski D, King D, Kennedy M.

68, 69. Australian College of Surgeons ASC, Melbourne, May 2004.

Thornton MJ, Kennedy ML, King DW, Lubowski DZ.


Botulinum Toxin for chronic anal fissure: prospective manometric assessment of 60 patients.

Thornton MJ, Kennedy ML, King DW.

70, 71, 72. Association of Coloproctology of Britain and Ireland, Birmingham, UK, June 2004.




(poster)


Validation of the high frequency wave form demonstrated in the hypertonic internal anal

sphincter: the Fast Wave. (poster)


73. American College of Colon and Rectal Surgery, Philadelphia, USA, April 2005.



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Invited Presentations:

1. Royal Prince Alfred Hospital, Surgical Guest Lecture.

Restorative Proctocolectomy

Sydney, 8th March 1988

2. Royal Australasian College of Surgeons CME Programme

Flinders Medical Centre, Adelaide, 26th March 1988

Colonoscopy - Normal landmarks; Demonstration

3. Royal Australasian College of Surgeons, Annual Scientific Meeting

Brisbane, 3rd May 1988

Pathophysiology of Obstructed Defaecation

4. Gastroenterological Society of Australia, Scientific Meeting

Newcastle, 7th October 1989

Surgical management of constipation.

5. Royal Australian College of Medical Administrators

Sydney, 1st November 1990

The Organisation of Health Services in the 1990’s

6. Royal Australasian College of Surgeons General Scientific Meeting

Sydney, May1991

Colonoscopy Workshop: Technique and Demonstration

7. Royal Australasian College of Surgeons CME Programme

Brisbane, 1991

Surgical management of rectal prolapse

8. Royal Australian College of Medical Administrators

Sydney, 28th May 1992

The Organisation of Health Services in the 1990's - A Clinical Divisional View

9,10. University of Wollongong Graduate School of Health and Medical Sciences

Sydney, June 1993

The Australian Health Care System: Policy and Politics

"Who Makes the rules"

"Professions in Transition"

11. Community Health Forum, Eastern Area Health Service

Sydney, 27th August 1993

Acute Health Homecare: Budgets and Cost Effectiveness

12.Clinical Budgeting Workshop

Policy and Planning Branch, Queensland Health

Brisbane,16Sep94

15

13.Executive Education Seminars SSAHS 25Jul94

“Strategic Directions in Health Care”

14. National Programme of Management Development for Australian Clinicians

Melbourne 24-25Nov94

“Management is not Administration”

15. “Clinical Management”

Toowoomba Hospital

Toowoomba 13Feb95

16. “The Relevance of Costing and Clinical Budgeting to Clinicians”

“Economics of Health Care”

“Information Systems and Clinical Management”

Prince Charles Hospital, Brisbane, 25May95

17. “Best Practice - NDHP Perspective

NSW Health Best Practice Seminar

Sydney 07Aug95

18. “Motivating Doctors for Cultural Change”

AHA Congress 95

Adelaide, 27Oct95

19. “The Future of Large Teaching Hospitals”

Orientation Program for NSW Health Directors

Sydney, 16Aug96

20. “The Difficult Polyp”

RACS Section of Colorectal Surgery CME Conference/Sydney Colorectal Surgical Society

Sydney, 09Nov96

21. “Quality in Australian Health Care”

World Bank study tour

Sydney, Feb97

22. “Colonoscopic screening: how often is too often?”

ASM Sydney Colorectal Surgical Society

Sydney Nov99

23. “Screening tests for bowel cancer and investigaying bowel symptoms

NSW Cancer Council and St George Division of General Practice

28th

August 2001

24. “Chronic constipation following pelvic surgery’

Pelvic Floor Symposium, Australian Gynaecological Endoscopy Society

14th

September 2001

16

25. ‘Screening tests for bowel cancer”

Prevention, Screening and Familial Aspects of Bowel Cancer

The Cancer Council, NSW

29th

August 2001

26. “Synchronous treatment of primary and secondary colorectal cancer – The St George

experience”

St George Liver Oncology Group

19th

October 2003

27. “Recent advances in Colorectal Cancer”

Gujarat Cancer and Research Institute, Ahmedabad, India

31st May 2004

28. Screening colonoscopy- indications

Royal Australasian College of Surgeons CME Programme

September 2004

17

Publications - Original Articles:

1. Brooke B N, Cave D R, King D W.

The place of Azathioprine for Crohn's Disease

Lancet 1976; 1041-42

2. King D W.

Melaena due to ectopic pancreas in enteric duplication - a case report

Singapore Medical Journal 1976, 17:56-57

3. Hanel K C, King D W, McAllister E T, Reiss-Levy E.

Single-dose Parenteral Antibiotics as Prophylaxis Against Wound Infections in Colonic

Operations

Diseases of the Colon and Rectum 1980, 23:98-101

4. King D W, Lubowski D Z, Talley N A, Pryor D S.

Restorative proctocolectomy with ileal reservoir and ileoanal anastomosis - a clinico-

physiological study.

Aust NZ J Surg 1987; 57:555-558

5. Bruck C E, Lubowski D Z, King D W.

Do patients with haemorrhoids have pelvic floor denervation?

International J Colorectal Dis 1988; 3:210-214

6. Lubowski D Z, King D W

Recto-anal reflex after rectal excision. Br J Surg 1988; 75:1150 (letter)

7. King D W, Lubowski D Z, Cook T A.

Anal canal mucosa in restorative proctocolectomy for ulcerative colitis.

Br J Surg 1989; 76: 970-972

8. McLean R G, Smart R C, Gaston-Parry D, Barbagallo S, Baker J, Lyons N R, Bruck C E, King D W,

Lubowski D Z, Talley N A.

Colon transit scintigraphy in health and constipation using oral I-131 cellulose.

J Nuclear Med 1990; 31:985-989

9. King D W, Lubowski D Z, Armstrong A S.

Sigmoid stricture at colonoscopy - an indication for surgery.


10. Beevors M A, Lubowski D Z, King D W, Carlton M A.

Pudendal nerve function in women with symptomatic utero-vaginal prolapse.


11. Smart R C, McLean R G, Gaston-Parry D, Barbagallo S, Bruck C E, King D W, Lubowski D Z,

Talley N A.

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Comparison of I-131 cellulose and I-111 DTPA as tracers for colon transit scintigraphy - analysis

by colon activity profiles.

J Nuclear Med 1991; 32:1668-1674

12. Lubowski D Z, King D W

Faecal Incontinence (review article)

The National Continence Newsletter, Continence Foundation, No VAW8179 p14 1991

13. Lubowski D Z, King D W, Finlay I G.

Electromyography of the pubococcygeus muscles in patients with obstructed defaecation.


14. McLean R, Smart R C, Lubowski D Z, King D W, Barbagallo S, Talley N A.

Oral colon transit scintigraphy using indium-111 DTPA: variability in healthy subjects.


15. Merrett N D, Lubowski D Z, King D W.

Torsion of the vermiform appendix: a case report and review of the literature.

Aust NZ J Surg 1992; 62:981-983

16. Lubowski DZ, King DW, Lam TCF.

Surgical Management of Anal Incontinence

Annals Academy of Medicine, Singapore 1992; 21:280-283

17. Jorgensen J, Stein P, King D W, Lubowski D Z.

The anorectal angle is not a reliable parameter on defaecating proctography.

Aust NZ J Surg 1993; 63:105-108

18. Lam T C F, Islam N, Lubowski D Z. King D W.

Does squatting reduce pelvic floor descent during defaecation?

Aust NZ J Surg 1993; 63:172-174

19. Meagher AP, Lubowski DZ, King DW.

The cough response of the anal sphincter

Intnl J Colorectal Dis

1993, 8:217-219

20. Salaman JR, Griffin PJ, Ross WB, Lubowski DZ, King DW, Peters L, Nour R, Quinn RJ, Morris

DL, Butler SP

Avid thallium uptake in hepatic carcinoid metastases

Eur J Nucl Med 1993; 20(9); 804-6

21. Adams W J, Meagher A P, Lubowski D Z, King D W.

Bisacodyl reduces the volume of polyethylene glycol solution required for bowel preparation.

Dis Colon Rectum 1994;37;229-234

22. Adams WJ, Morris DL, Ross WB, Lubowski DL, King DW, Peters L

19

Cimetidine preserves non-specific immune function after colonic resection for cancer

Aust N Z J Surg 1994;34;847-852

23. Young C, Kennedy ML, Lubowski DZ, King DW

Post-anal Repair for Faecal Incontinence - long term follow-up

Journal of Gastroenterology and Hepatology 1994;9;A113

24. Lubowski DZ, King DW

Obstructed Defecation: Current Status of Pathophysiology and Management

Aust. N.Z.J. Surg. (1995) vol65, 87-92

25. McLean R, Smart R, Barbagallo S, King D, Stein P, Talley N

Colon Transit Scintigraphy Using Oral Indium-111-Labelled DTPA. Can Scan Pattern Predict Final

Diagnosis?

Digestive Diseases and Sciences, (1995) vol40, 2660-2668

26. Dasappa V, Ross WB, King J, King DW, Clingan PR, Morris DL

Primary resection and synchronous regional hepatic chemotherapy or cryotherapy for

colorectal cancer with liver metastases.

Intnl J of Colorectal Disease 1996;11;nr1;38-41

27. Brookes SJH, Lam TCF, Lubowski DZ, Costa M, King DW

Regeneration of nerves across a colonic anastomosis in the guinea-pig

Journal of Gastroenterology and Hepatology (1996) vol11, 325-334

28. Kennedy ML, Nguyen H, Lubowski DZ. King DW

Stimulated gracilis neosphincter: A new procedure for anal incontinence

Aust. N.Z.J. Surg. (1996) vol66, 353-357

29. Lubowski DZ, Chen FC, Kennedy ML, King DW

Results of colectomy for severe slow transit constipation

Dis Colon Rect 1996; 39:23-29

30. Talley NA, Chen FC, King DW, Jones M, Talley NJ

Short-Chain Fatty Acids in the Treatment of Radiation Proctitis

Dis Colon Rect 1997; 40:1046-1050

31. McLean RG, King DW, Tallet NA, Tait AD, Frieman J

The Utilization of Colon Transit Scintigraphy in the Diagnostic Algorithm for Patients with

Chronic Constipation

Digestive Dis and Sciences 1999; 44:1;41-47

32. Finlay IG, Dwerryhouse SJ, King J, King DW, Lubowski DZ, Morris DL

The effect of a short preoperative course of cimetidine on the grade of TIL in primary colorectal

cancer - a randomised controlled clinical trial

GI Cancer (1999) vol3, 121-127

33. Kelly M, King J, Cherian M, Dwerryhouse S, Finlay I, Adams W, King DW,

20

Lubowski DZ, Morris DL

Randomised trial of preoperative cimetidine in patients with colorectal cancer with quantitative

assessment of tumour - associated lymphocytes

Cancer (1999) vol 85, 1958-63

34. Horsell KW, Merten S, Clingan PR, King DW, Morris DL

Peritonectomy and intraperitoneal chemotherapy in appendiceal and colorectal cancer

Aust NZ J Surg (1999) 69:729-32

35. Young CJ, Simpson RR, King DW, Lubowski DZ

Oral sodium phosphate is a superior colonoscopy preparation to polyethylene glycol with

bisacodyl

Dis Colon Rectum 2000; 43:1568-1571

36. S Chew, King DW

Use of Endoscopic Titanium Stapler in Rectal Anastomotic Stricture


37. M L Kennedy, D Z Lubowski, D W King

Transanal Endoscopic Microsurgery. Is Anorectal Function Compromised?


38. L Schmidt, P Williams, D King, S Perera

Picoprep-3 is a superior colonoscopy preparation compared to Fleet

Dis Colon Rectum 2004;47(2);238-242

39. Dinning PG, Bampton PA, Andre J, Kennedy ML, Lubowski DZ, King DW, Cook IJ

Abnormal predefecatory colonic motor patterns define severe constipation in obstructed

defecation

Gastroenterology 2004;127(1):49-56

40. Wong SW, King DW

Surgical Techniques; Sutureless Intestinal Plication

ANZ J Surg 2004;74(8):681-83

41. Thornton MJ, Kennedy ML, King DW, Lubowski DZ

Long-term follow-up of dynamic graciloplasty for faecal incontinence

Colorectal Disease 2004;6:470-76.

42. Dinning PG, Bampton PA, Andre J, Kennedy ML, Lubowski DZ. King DW, Cook IJ.

Abnormal predefecatory colonic motor patterns define constipation in obstructed defecation.

Gastroenterology 2004; 127:49-58

43. Thornton MJ, Kennedy ML, King DW,Lubowski DZ.

The High Frequency Wave Form (Fast Qave) in the hypertonic internal anal sphincter. Validation

of a new observation.

Colorectal Disease 2004; 6(suppl 1): 69

21

44. Thornton MJ, Lam A, King DW

Laparoscopic or pelvic floor repair of rectocoele? A retrospective matched cohort study.

Dis Colon Rectum 2005;48:792-98


Bowel, bladder and sexual function in women undergoing laparoscopic posterior compartment

repair in the presence of apical or anterior compartment dysfunction.

Aust NZ J Obstet Gynaecology 2005;45:195-200

46. Thornton MJ, Kennedy ML, King DW


Dis Colon Rectum 2005;48(7):1424-31

(Paper awarded Mark Killingback Prize for Colorectal Research at the ANZCS ASC Melbourne

May 2004)


Manometric assessment of acute anal fissure and physiological effect of topical glyceryl

trinitrate – prospective trial

Dis Colon Rectum 2005;48960: 1207-12

48. Dinning PG, Bampton PA, Kennedy ML, Lubowski DZ, King DW, Cook IJ

Impaired proximal colonic motor response to rectal and chemical stimulation in obstructed

defecation. Dis Col Rectum 2005; 48(9): 1777-1784

49. Thornton MJ, Kennedy ML, King DW, Lubowski DZ

Electromagnetic stimulation of the Pelvic Floor for idiopathic faecal incontinence: effect on

anorectal physiology

Dis Colon Rectum 2005;38(10):1945-50

50. Thornton MJ, Lubowski DZ, Kennedy ML, King DW

Faecal Incontinence, a multifactorial problem. (submitted for publication)

51. Dinning PG, Fuentealba SE, Kennedy ML, Lubowski DZ, King D, Cook IJ.

Sacral nerve stimulation induces pan-colonic propagating pressure waves and increases

defaecation frequency in patients with slow transit constipation. Colorectal Dis 2007; 9(2):123-

32

52. Yan TD, Chu F, Black D, King DW, Morris DL

Synchronous Resection of Colorectal Primary Cancer and Liver Metastases

World J Surg (2007) 31:1496-1501

53. Nielsen HJ, Brunner N, Frederiksen C, Lomholt AF, King DW, Jorgensen LN, Olsen J, Rahr HB,

Thygesen K, Hoyer U, Laurgerb S, Christensen IJ

Plasma tissue inhibitor of metalloproteinases-1 (TIMP-1): A novel biological marker in the

detection of primary colorectal cancer. Protocol outlines of the Danish-Australian endoscopy

study group on colorectal cancer detection

22

Scandinavian Journal of Gastrolenterology (2007) (accepted for publication)

54. Mackey P, King D, Lubowski D

Post-anal repair. Do the long-term results justify the procedure?

Colorectal Disease 2008 (accepted for publication)

55. Burcher E, Shang F, Warner FJ, Du Q, Lubowski DZ, King DW, Liu L

Tachykinin NK2 receptor and functional mechanisms in human colon: changes with

indomethacin and in diverticualr disease and ulcerative colitis.

J Pharmacol Exp Ther. 2008 324:170-178

56. Liu L, Markus I, El Saghire H, Perera D, King D, Burcher E

Tachykinin gene expression in human smooth muscle and mucosa: disctinct differences in

ulcerative colitis, Crohn’s disease and diverticular disease.

American Journal of Physiology (accepted for publication 18Nov09)

57. Liu L, Shang F, Morgan MT, King DW, Lubowski DZ, Burcher E.

Cyclooxygenase-dependent alterations in substance P-mediated contractility and NKI receptor

expression in the colonic circular muscle of patients with slow transit constipation

J Pharmacol Exp Ther. 2009 329:282-289

58. Dinning PG, Jones M, Fuentealba SE, Kalanter K, King DW, Lubowski DZ, Talley NJ, Cook IJ.

Factor analysis identifies subgroups of constipation. World J Gastroenterol. 2011. 17(11): 1468-

74

23

Review Articles:

1. Lubowski D Z, King D W.

Faecal Incontinence. The National Continence Newsletter, Continence Foundation, No.

VAW8179, pp14, 1991

2. Lubowski D Z, King D W, Lam T C F.

Surgical management of anal incontinence.

Annals Academy of Med, Singapore 1992; 21:280-283

Monographs and Book Chapters:

1. Brooke B N, Cave D A, Gurry J F, King D W.

Crohn's Disease

Pub. Macmillans London 1976

2. Lam T C F, Lubowski D Z, King D W.

Solitary Rectal Ulcer Syndrome

In: Clinical Gastroenterology. Vol: Anorectal Disorders (Henry MM, Ed.)

Bailliere Tindall/ W B Saunders, London, 1992, Vol 6/1, pp129-143

3. Meagher A P, Adams W J, Lubowski D Z, King D W.

Anatomy of Rectum and Anus.

In: Colorectal Physiology: Fecal Incontinence (Kuijpers H C, Ed.)

CRC Press, Florida, 1994

4. King DW

Colorectal Cancer

In: Cancer: A Comprehensive Clinical Guide (Morris et al, Ed)

Harwood Academic Publishers, 1998

24

Publications – Abstracts/Letters:

1. King D W, Lubowski D Z, Bruck C E.


Aust NZ J Surg 1988; 58:243

2. Lubowski D Z, King D W, Bruck C E.


Br J Surg 1988; 75:1269-1270

3. McLean R, Gaston-Parry D, Smart R, Barbagallo S, Baker J, Lyons N, King D W, Lubowski D Z.

Oral In-111 DTPA: Its value for routine clinical assessment of colon transit.

J Nuclear Med 1989; 30:887

4. McLean R, Gaston-Parry D, Smart R, Barbagallo S, Baker J, Lyons N, King D W, Lubowski D Z.

Colon transit in health and constipation assessed using I-131 cellulose.

J Nuclear Med 1989; 30:764-765

5. Smart R, McLean R, Willson J, Barbagallo S, Gaston-Parry D, Lyons N, Lubowski D Z, King D W,

Bruck C E.

Colon transit in health and constipation: analysis using colon activity-profiles.

ANZ J Med 1990; Suppl 1:445

6. Smart R, McLean R, Wilson J, Barbagallo S, Gaston-Parry D, Lyons N, Lubowski D Z, King D W,

Bruck C E.

The assessment of colon transit in adults using In-111 DTPA and colon activity profiles.

Europ J Nuclear Med 1990; 16(suppl):S319

7. McLean R, Smart R, Lubowski D Z, King D W, Bruck C E.

Colon transit scintigraphy - normal ranges and variability in normal subjects.

ANZ J Med 1991; 21:633

8. McLean R, Smart R, Lubowski D Z, King D W, Stein P.

Colon transit scintigraphy in idiopathic constipation - can scan patterns predict pathology?

ANZ J Med 1991; 21:633

9. Lubowski D Z, King D W, McLean R G, Smart R, Gaston-Parry D.

Oral In-111 DTPA scintigraphy: its value for assessment of colon transit in severe constipation.

ANZ J Surg 1991;

10. McLean R G, Smart R C, Lubowski D Z, King D W, Bruck C E.

Colon transit scintigraphy: normal ranges and variability in normal subjects.

Aust NZ Soc Nucl Med 1991; 67

11.Adams WJ, King DW, Lubowski DZ, Morris DL

Cimetidine prevents postoperative suppression of immune function following colorectal cancer

surgery

25

Gut 1994; 35:S16

12. Young C, Kennedy M, Lubowski DZ, King DW

Postanal repair for faecal incontinence - long-term results

J Gastroenterol Hepatol 1994; 9:A113

13. Lubowski DZ, Kennedy M, King DW

Chemical sphincterotomy for anal fissure - a new treatment

Aus NZ J Surg 1995; 65:423

14. Adams WJ, Meagher AP, Lubowski DZ, King DW

Bisacodyl reduces the volume of polyethylene glycol solution required for bowel preparation

Gastroenterol Digest, May 1995; 15-16

15. Stewart GJ, Preketes AP, Lubowski DZ, King DW, Morris DL

Colorectal cancer response to high-dose sandostatin therapy: A clinical trial

Aust NZ J Surg 1995; 65:435

16. Burcher E, Warner FJ, Shang F, Markus I, Liu L, King DW, Lubowski DZ

Characterisation and autoradiographic localisation of tachykinin receptors in human colon

3rd

Australian Peptide Conference – From discovery to Therapeutics; Oct 1998

17. Burcher E, Warner FJ, Shang F, Markus I, Liu L, King DW, Lubowski DZ

Tachykinins in the human colon

Western Pharm Soc Maui, USA; Feb 1999

18. Dinning PG, Bampton PA, Andre J, Kennedy ML, Lubowski DZ, King DW, Cook IJ.

Constipation due to obstuted defaecation is likely to be a colonic rather than an ano-rectal

disorder.

Gastroenterology 2001:125(5)(Supl1);A751. (Presented American Gastroenterological

Association cinference, Atlanta May 2001)

19. Dinning PG, Bampton PA, Kennedy ML, Lubowski DZ, King DW, Cook IJ

Heightened rectal sensory thresholds and blunted recto-colonic motor reflexes implicated in

constipation due to obstructed defaecation.

Gastroenterology 2002; 122(4) A316. (Poster presentation at AGA Conference, San Francisco,

May 2002)

20. Azriel Y, Grimm M, Lubowski DZ, King DW, Burcher E.

Alterations in neurotensin receptors and responsiveness in slow transit constipation

AHMR Melbourne, Dec 2002; Proc Aust Health Med Res Congress 2002

21. Thornton MJ, Kennedy ML, Lubowski DZ, King DW

Long-term follow-up of Dynamic Graciloplasty for Faecal Incontinence

Am J Gastroenterology 2003;29(9 suppl) S1-339

22. Thornton MJ, Kennedy ML, King DW, Lubowski DZ.

26

The high frequency wave form (fast wave) in the hypertonic internal anal sphincter: validation


Am J Gastroenterology 2003;29(9 suppl) S1-339

23. Cosman D, Thornton MJ, Cross KM, King DW, Morris DL.

Hepatic metastasis from colorectal cancer: analysis of morbidity and mortality of synchronous

treatment.

Am J Gastroenterology 2003;29 (9 suppl) S1-339



Colorectal Dis 2004;6(suppl 1):30


Botulinum Toxin for chronic anal fissure: prospective manometric assessment of 60 patients

ANZ J Surg 2004; 74 (Suppl) A34-A41 (CR21)



ANZ J Surg 2004; 74 (Suppl) A30-A41 (CR 25)



Colorectal Dis 2004;6(suppl 1):68 (P096)

Am J Gastroenterology 2003;29 (9suppl) S1-339

28. Phan-Thien K-C, Perera DS, King DW

Patient Compliance with Recall Colonoscopies – What is Good Enough?

ANZ J Surg. 2004; 74 (Suppl) A35


Laparoscopic or transanal repair of rectocele? A retrospective matched cohort study.

ANZ J Surg 2004;74 (Suppl) A30-A41 (CR 42P)




Colorectal Dis 2004;6(suppl 1):69 (P098)




J Gastroenterology & Hepatology 2004;18(suppl):B44


27



ANZ J Surg 2004; 74 (Suppl) A30-A41 (CR 41P)

Am J Gastroenterology 2003;29 (9suppl) S1=339

33. Burns HL, Thornton MJ, King DW.

Pre-existing pelvic floor dysfunction prior to transanal rectocele repair: a retrospective analysis.

ANZ J Surg 2004;74 (suppl) A30-A41 (CR 52P)

34. Thornton MJ, Cross KM, King DW, Lubowski DZ, Morris DL.

Assessment of the value of the pre-operative abdominal CT in colorectal cancer.

J Gastroenterology & Hepatology 2004;18(suppl):A B4

35. Saafan AK, Thornton MJ, Gebski V, King DW.

The prevalence of diverticular disease in patients with slow transit constipation.

J Gastroenterology & Hepatology 2003;18(auppl):A B42

Am J Gastroenterology 2004;29 (9 suppl) S1-339

36. Byrne CM, Perera DS, King DW

Does rectal washout during anterior resection prevent local tumour recurrence?

Dis Colon Rectum 2005;48L172-4

37.Thornton MJ, Lam AM, King DW.

Bowel, bladder and sexual function in women undergoing laparoscopic posterior compartment

repair in the presence of apical or anterior compartment dysfunction.

Aust N Z J Obstet Gynaecol. 2005;45:195-200

28

Research Grants obtained:

NHMRC grant 157134. 2001-2003. Associate Investigator

Motor patterns of colonic transit and pathophysiology of severe constipation.

NHMRC grant 222739. 2002-2005. Associate Investigator

Neurochemicals and neuromodulators in human intestine: changes in disease.

NHMRC 568861. 2009-2011. Associate investigator

Hemokinin – a new inflammatory mediator in the intestine

Postgraduate students supervised:

M J Thornton: MD (UNSW) 2005 – Benign Anorectal Disorders

V Patton: PhD (UNSW) 2010 – Constipation and Incontinence

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