Genetic Data Management Platform

PROVIDING THE BUILDING BLOCKS FOR PERSONALIZED HEALTHCARE

V1.04

ABOUT US 1900 UNIQUE SITES 78 COUNTRIES

UNITED STATESARUP LabsBaylor College of MedicineBristol Meyers SquibCedars-Sinai Medical CenterChildren's Hospital of PhiladelphiaCity of HopeCleveland Clinic FoundationColumbia UniversityDana Farber Cancer InstituteDuke University Medical CenterGENENTECHGlaxoSmithKlineHarvard Medical SchoolJohn Hopkins School of MedicineMayo ClinicMemorial Sloan-Kettering Cancer CenterMGHNational Cancer InstituteNational Institutes of HealthStanford University

UCLA School of MedicineUniversity of California, IrvineUniversity of IowaUniversity of PennsylvaniaUniversity of PittsburghUniversity of Texas, MD Anderson Cancer CenterUniversity of UtahUSCVanderbilt University

CANADAAlberta Children’s HospitalBC Cancer AgencyMcGill University Health CentreMemorial University NewfoundlandMount Sinai HospitalOntario Cancer Treatment & Research FoundationRCMP Central Forensic LabThe Hospital for Sick ChildrenToronto General HospitalToronto-Sunnybrook

SINCE 1996

A FEW MORE OF OUR 1900 CLIENTS

UNITED KINGDOM - EUROPEAarhus University Hospital, AASBelfast City HospitalCambridge UniversityCCK, Karolinska InstituteErasmus University-RotterdamHelsinki University Central HospitalHopital Neckler Enfants MaladesIceland Genomics/UVSInstitute of Cancer ResearchKarolinska HospitalLeiden University Medical CenterMalmö University HospitalSt. James's HospitalThe Royal Edinburgh HospitalUniversity of LeuvenUniversity of OsloUniversity of RegensburgUniversity of TartuUniversity of ViennaUppsala University Wellcome Trust Centre for Human Genetics

AUSTRALIA – NEW ZEALANDAuckland HospitalInternational Diabetes InstitutePeter McCallum Cancer InstituteQueensland Institute of Medical ResearchRoyal Melbourne HospitalSt. George HospitalSt. Vincent's HospitalUniversity of OtagoWestmead Hospital

MIDDLE EAST – FAR EASTCancer Institute WIAJunshinkai Familial Cancer InstituteKing Faisal Specialist Hospital & Research CentreNational Cancer Center Research InstituteNational Taiwan UniversityRadiation Effects Research FoundationSamsung Cheil Hospital, Sungkunkwan UniversityTaipei Medical UniversityUAE UniversityWeizmann Institute of Science

THE PROGENY GENETICS PLATFORM

CLINICALPedigree and Clinical Data

LABGenotype Data Management

LIMSComplete Sample Management

FHQFamily History Questionnaire

Data is gathered directly from the patient and entered into the database.

PROGENY WORKFLOW

PATIENT STAFF

EMR

Patient creates secure login and can log in and out while researching family history.

Genetic Counselor or clinician receives email when patient is done and reviews the pedigree and data.

After reviewing, submit data to your EMR for historical patient record.

Questionnaire DMZ

WEB BROWSERWINDOWS PC

ADMINISTRATOR

Progeny Suite

Secure data capture is integrated into the solution.

STAFFPATIENT

EMR

WEB BROWSER

PROGENY CLIENT

PROGENY ARCHITECTURE

Integration Platform (PIP)

Other Databases & Files

ELECTRONIC MEDICAL RECORD

Custom Endpoints (i.e. Robotics)

PROGENY ARCHITECTURE

Family History Questionnaire

Design - One-time initial customization fee of $5,000• Includes configuration & design of two questionnaires

Tier I - Annual Patient Access Fee $5,000 • 1,000 submitted questionnaires per year

Tier II - Annual Patient Access Fee $10,000• 2,500 submitted questionnaires per year

Tier III - Annual Patient Access Fee $15,000• 5,000 submitted questionnaires per year

Tiered pricing based on concurrent users:Tier # of users Initial License Fee Annual PSPBasic 2 users $4,000 $1,000 I 5 users $9,800 $2,450II 10 users $19,000 $4,750III 15 users $27,000 $6,750IV 20 users $34,000 $8,500V 25 users $40,000 $10,000

(Site licensing also available)

Progeny defines “endpoints” to communicate with your systems.

These are inbound or outbound messages that can be any protocol such as HL7, ADT, web services, file transfers, etc…

Unique “Open Model” DOUBLES your access:Tier # of users Extended accessBasic 2 users Open to 5 usersTier I 5 users Open to 10 usersTier II 10 users Open to 20 usersTier III 15 users Open to 30 usersTier IV 20 users Open to 40 usersTier V 25 users Open to 50 users

Pricing is based on a per service option.

Publishing pedigrees to the EMR is one service.

Importing data from your EMR is another service.

90 days prior to your PSP renewal, we will review your usage. If the average number of concurrent users has gone beyond your tier, you can opt to keep the open model by upgrading to the next tier or cap your users at the current tier.

March 21, 2012Potential reimbursement for 2014.

New Questionnaire

With the FHQ product, you can email questionnaires to patients to complete prior to their clinic visit.

New Questionnaire

Select the Questionnaire you want to send.

New Questionnaire

Enter the family name of the patient.

New Questionnaire

Enter the Gender of the proband.

New Questionnaire

Enter the information and email address of the patient and click Send Invite.

Login Screen

Patient receives email and after clicking the link, is taken to a login screen.

Confirmation Screen

Patient is asked to confirm data and continue with questionnaire.

Create completely custom questions…

Patient follows prompts on each screen and can always logout and come back later.

Demographic Information

Example Use of Skip Logic

Example Use of Skip Logic

Example Use of Skip Logic

Example Use of Skip Logic

Family Structure Prompt

Family Structure Prompt

Nieces and Nephews Capture Screen. We also capture Cousins if you want.

Customizable Family Table

Skip Logic is now built into the Family Table.

Separate In-take Form for Relatives

Catch-All Final Question

Display Family Tree + Info Review

Display Family Tree + Info Review

View Pedigree + Review Data

After the patient completes the questionnaire, an email notifies the clinician, who can login to Progeny and review the pedigree.

Review Pedigree

HIGH – MEDIUM – LOW RISK BASED ON REFERRAL CRITERIA AS ESTABLISHED BY THE NCCN:Breast, Ovarian, Colon, Gastric, Hematologic, Li-Fraumeni, Melanoma, MEN, Thyroid, Pancreatic, Prostate, Renal and rare tumors associated with an inherited risk, family clusters of the same cancer.

We offer an optional risk assessment tool called GENTRI that was developed by the Hubert Humphrey Cancer Center and will determine risk for a patient for the following diseases….

Review Pedigree

New Toggle Data Sheet feature allows you to review and edit data within the pedigree viewer

INDIVIDUAL DATASHEET

Double-click individuals to open a more expanded view of data sheets that can be setup any way you like.

Example – Pedigree Image into your EMR

PROGENY INTEGRATIONSERVICES

PEDIGREE FROMPROGENY CLINICAL

PROGENY INTEGRATION PLATFORM (PIP)

A Genetic Counselor uses Progeny to compose a Pedigree describing a patient’s family history as it relates to cancer risk. When the Pedigree is finished, she selects ‘Send to EMR’ from Progeny.

PIP

PROGENY SUPPORT PLAN (PSP)

PSP IS AN ANNUAL SUPPORT PLAN THAT PROVIDES:

• Unlimited 800 Phone and email support FREE

• GoToMeeting support sessions for FREE

• Updates, New Releases, tech support for FREE

• Open Model licensing that DOUBLES staff access

• Custom training available on-site or via GoToMeeting

• On-line video tutorials available via our website

WHY PROGENY?

WE’RE COMMITTED TO…

• Utilize 17 years of software expertise to service over 1900 unique sites in 78 countries.

• Listen to our customers and deliver the most effective and efficient customized solution – we don’t oversell!

• Deliver personalized training and tools to get you up and running without delay – at no additional cost.

• Provide exceptional toll-free support – answered live by knowledgeable technicians.

• Believe that if you’re completely satisfied, we’ll both be successful.

CONTACT US

QUESTIONS?

Conrad BrammerAccount Executive

Progeny Software, LLC800 Palm Trail, Suite 200 Delray Beach, FL 33483

1.800.PROGENY Ext 211866.479.6801 Fax

www.progenygenetics.com

cbrammer@progenygenetics.com