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ProMIS TM Neurosciences, Inc. NEWS RELEASE TSX: PMN/FOR IMMEDIATE RELEASE PROMIS NEUROSCIENCES ANNOUNCES PRIVATE PLACEMENT NOT FOR DISTRIBUTION TO U.S. NEWSWIRE SERVICES OR DISSEMINATION IN THE UNITED STATES Toronto, February 23, 2016 - ProMIS Neurosciences Inc. (the “Company”) announced today that it is offering (the “Offering”) on a private placement basis up to 16,666,667 shares at a price of $0.06 per share for gross proceeds of up to CDN $1,000,000. The Company will pay finders’ fees of 7% on a portion of the proceeds of the Offering. The net proceeds are estimated at $950,000 based on gross proceeds of $1,000,000 less estimated finders’ fees of $30,000 and less estimated offering expenses of $20,000. The primary use of proceeds will be to validate and optimize the several lead programs (up to six) ProMIS is developing against different strains of Amyloid beta (AB) in Alzheimer's Disease and Down’s syndrome. The program will seek to validate that the lead products selectively bind to the neurotoxic prion, or oligomeric form of AB, which the Company believes is the target product profile for successful precision therapies in these deadly diseases. The validation, done in part with cadaveric brain tissue of patients who died with diagnosed Alzheimer's, will also be used to support and enhance ProMIS's patent estate. Approximately 62 percent of net proceeds ($590,000) will be used for research and development, including the in vitro validation program as outlined above, and the associated IP filings and support. Also included are maintenance costs associated with the Company’s existing IP portfolio; Approximately 38 percent of net proceeds ($360,000) will be used for general corporate purposes, and investor relations. All shares issued will be subject to a four month hold period from the date of issuance in accordance with applicable securities law. Closing of the Offering is subject to receipt of TSX acceptance. The Company confirms that there is no material fact or material change about the Company that has not been generally disclosed. Insiders of the Company are expected to participate in the Offering (the “Insider Participation”), which will be considered a related party transaction within the meaning of Multilateral Instrument 61-101 (“MI 61-101”). The Company intends to rely on the exemptions from the valuation and minority shareholder approval requirements of MI 61-101 contained in Sections 5.5(a) and 5.7(1)(a) of MI 61-101 in respect of such Insider Participation, which the Company expects to be approximately $110,000. This press release shall not constitute an offer to sell or the solicitation of an offer to buy nor shall there be any sale of the securities in any state in which such offer, solicitation or sale would be unlawful. The securities issued, or to be issued, under the Offering have not been, and will not be, registered under the United States Securities Act of 1933, as amended, and may not be offered or sold in the United States absent registration or an applicable exemption from registration requirements.
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Page 1: ProMISTM Neurosciences, Inc. - Renmark Financial€¦ · Like us on LinkedIn Renmark Financial Communications Inc. Barry Mire: bmire@renmarkfinancial.com or contact Dr. Elliot Goldstein

ProMISTM Neurosciences, Inc. NEWS RELEASE TSX: PMN/FOR IMMEDIATE RELEASE PROMIS NEUROSCIENCES ANNOUNCES PRIVATE PLACEMENT

NOT FOR DISTRIBUTION TO U.S. NEWSWIRE SERVICES OR DISSEMINATION IN THE UNITED

STATES

Toronto, February 23, 2016 - ProMIS Neurosciences Inc. (the “Company”) announced today that it is

offering (the “Offering”) on a private placement basis up to 16,666,667 shares at a price of $0.06 per

share for gross proceeds of up to CDN $1,000,000. The Company will pay finders’ fees of 7% on a

portion of the proceeds of the Offering.

The net proceeds are estimated at $950,000 based on gross proceeds of $1,000,000 less estimated finders’

fees of $30,000 and less estimated offering expenses of $20,000.

The primary use of proceeds will be to validate and optimize the several lead programs (up to six)

ProMIS is developing against different strains of Amyloid beta (AB) in Alzheimer's Disease and Down’s

syndrome. The program will seek to validate that the lead products selectively bind to the neurotoxic

prion, or oligomeric form of AB, which the Company believes is the target product profile for successful

precision therapies in these deadly diseases. The validation, done in part with cadaveric brain tissue of

patients who died with diagnosed Alzheimer's, will also be used to support and enhance ProMIS's patent

estate.

Approximately 62 percent of net proceeds ($590,000) will be used for research and development,

including the in vitro validation program as outlined above, and the associated IP filings and

support. Also included are maintenance costs associated with the Company’s existing IP

portfolio;

Approximately 38 percent of net proceeds ($360,000) will be used for general corporate

purposes, and investor relations.

All shares issued will be subject to a four month hold period from the date of issuance in accordance with

applicable securities law. Closing of the Offering is subject to receipt of TSX acceptance. The Company

confirms that there is no material fact or material change about the Company that has not been generally

disclosed.

Insiders of the Company are expected to participate in the Offering (the “Insider Participation”), which

will be considered a related party transaction within the meaning of Multilateral Instrument 61-101 (“MI

61-101”). The Company intends to rely on the exemptions from the valuation and minority shareholder

approval requirements of MI 61-101 contained in Sections 5.5(a) and 5.7(1)(a) of MI 61-101 in respect of

such Insider Participation, which the Company expects to be approximately $110,000.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy nor shall there

be any sale of the securities in any state in which such offer, solicitation or sale would be unlawful. The

securities issued, or to be issued, under the Offering have not been, and will not be, registered under the

United States Securities Act of 1933, as amended, and may not be offered or sold in the United States

absent registration or an applicable exemption from registration requirements.

Page 2: ProMISTM Neurosciences, Inc. - Renmark Financial€¦ · Like us on LinkedIn Renmark Financial Communications Inc. Barry Mire: bmire@renmarkfinancial.com or contact Dr. Elliot Goldstein

About ProMIS Neurosciences, Inc. The mission of ProMIS Neurosciences is to discover and develop precision medicine solutions for the

early detection and effective treatment of neurodegenerative diseases, in particular Alzheimer’s disease

and ALS.

ProMIS Neurosciences’ proprietary target discovery engine is based on the use of two, complementary

techniques. The Company applies its thermodynamic, computational discovery platform—ProMIS™ and

Collective Coordinates — to predict novel targets known as Disease Specific Epitopes (DSEs) on the

molecular surface of misfolded proteins. Using this unique "precision medicine" approach, ProMIS

Neurosciences aims to develop novel antibody therapeutics and specific companion diagnostics for

Alzheimer’s disease and ALS. The company has also developed two proprietary technologies to

specifically identify very low levels of misfolded proteins in a biological sample. In addition, ProMIS

Neurosciences owns a portfolio of therapeutic and diagnostic patents relating to misfolded SOD1 in ALS,

and currently has a preclinical monoclonal antibody therapeutic against this target.

The TSX has not reviewed and does not accept responsibility for the adequacy or accuracy of this release.

This information release may contain certain forward-looking information. Such information involves

known and unknown risks, uncertainties and other factors that may cause actual results, performance or

achievements to be materially different from those implied by statements herein, and therefore these

statements should not be read as guarantees of future performance or results. All forward-looking

statements are based on the Company's current beliefs as well as assumptions made by and information

currently available to it as well as other factors. Readers are cautioned not to place undue reliance on

these forward-looking statements, which speak only as of the date of this press release. Due to risks and

uncertainties, including the risks and uncertainties identified by the Company in its public securities

filings, actual events may differ materially from current expectations. The Company disclaims any

intention or obligation to update or revise any forward-looking statements, whether as a result of new

information, future events or otherwise.

For further information, please consult the Company's website at:

www.promisneurosciences.com,

Follow us on Twitter

Like us on LinkedIn

Renmark Financial Communications Inc. Barry Mire: [email protected]

or contact

Dr. Elliot Goldstein

President and Chief Executive Officer, ProMIS Neurosciences Inc.

Tel. 415 341-5783

[email protected]

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Renmark Financial Communications Inc. Barry Mire: [email protected] Tel: (416) 644-2020 or (514) 939-3989 www.renmarkfinancial.com

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