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By: José Santiago Camacho QuinteroMedicine student-III Semester
Universidad Pontificia Bolivariana
FOLDING
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During replication process can be some problems
that if they aren´t repaired is when
appear the mutations
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There are some types of DNA
repair mechanism. Each one with a serie of specific
proteins and enzymes
When these proteins and enzymes are ausent, repair
process failed and appears the
mutation
KLF8 protein is present in some types of cancer
Cause tumor cells resistance
Studies show that breast cancer is
present in 2.5-2.7 millions of women in
USA
Where those women are in treatment, there is a 10-20 percent of
recurrence
KLF8 protein promote resistance of the cells to
cell death induced by doxorubicin.
The goal is to stay KLF8 investigating the role of
protein in their interaction with other
genotoxic agents.
I think this is a good article because gives information about the role that have some proteins in the effectivity of chemotherapies in diferents types of cáncer, and incites to another authors to keep investigating about the DNA repair mechanism to find a treatment to cáncer.
Key is acetylation of protein histone h4
If acetylation is absent
activate non-homologus end joining by 53BPI
If there is acetylation,
activate homologus
recombination by BRCA1
This is a good article becuase it
talks about a process that
happen in DNA reparation, which one can helps to
find new tratment for cancer
Studies about DNA repair mechanism are so important
because it can helps to find new treatments for some patology relationated with mutations of
DNA
Cancer is a public health
problems because there are so many
factors to which
humans are exposed
Constantly
Both articles talk about development of breast cancer and ovarian cancer because DNA repair
mechanism proteins have failed.
For the last reasons, the articles give rise to find new and more efective trearments to cancer.
University of Pennsylvania School of Medicine Changes to DNA on-off switches affect cells' ability to repair breaks, respond to chemotherapy. ScienceDaily. Retrieved February 21, 2013, fromhttp://www.sciencedaily.com /releases/2013/02/130203145550.htm
University of Central Florida (2013, January 28). DNA-repairing protein may be key to preventing recurrence of some cancers. ScienceDaily. Retrieved February 23, 2013, from http://www.sciencedaily.com /releases/2013/01/130128104626.htm
Martinez LM, Vargas N, Toro AE, Pamplona AP, Quevedo E. Biologia molecular. 7 ed. Medellin, Colombia: Editorial Universidad Pontificia Bolivariana, 2012. pp: 85-96