Proteins, medical utility, diagnosis and treatment in

Alzheimer disease  

 

Juan Sebastian Marin Cardenas.Medicine student, III Semester.

Molecular Biology.

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DIFFERENTIAL PROCESSING OF AMYLOID PRECURSOR PROTEIN

IN BRAIN AND IN PERIPHERALBLOOD LEUKOCYTES.

 

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DIFFERENTIAL PROCESSING OF AMYLOID PRECURSOR PROTEIN

IN BRAIN AND IN PERIPHERALBLOOD LEUKOCYTES

• The reaction between APP and methaloproteases is an important mecanism for preventing the APP deposit and cell damage.

• The expresión of methaolproteases by the cells is different in tissues,

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DIFFERENTIAL PROCESSING OF AMYLOID PRECURSOR PROTEIN IN BRAIN AND IN

PERIPHERALBLOOD LEUKOCYTES.

•The cell has a Lot of molecular mecanisms to regulate the homeostasis of its extracell matrix, one of them is expresing some proteins that protects the cell and reguates the initial equilibrium

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OBSERVATION

The advanced knowledge of the Alzheimer disease and

investigation will aproach us to an early treatment that can improve the quality of life that the people with this patology

yearn.

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ADAM10 as a Biomarker for Alzheimer’s Disease: A Study with

Brazilian Elderly.

• Molecular signaling and proteins plays an important role in Amyliod protrein degradation involved in AD.

• Neurodegenerative process.

• ADAM10 is an important methaolprotease that catalyzes reacctions depending of some co-factors, degrading APP.

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ADAM10 as a Biomarker for Alzheimer’s Disease: A Study

with Brazilian Elderly.

•ADAM10 activity decreased in AD. That gives some clues for understanding the pathogenesis.

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The lack of ADAM10 and other proteins like neprilisin can boost the acumulation of this APP, that is caracteristly in AD in the brain.

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OBSERVATIONI think we must guide new studies about the impact of the AD in Colombia, for knowing the comportment of this pathology and corroborate the previous results and information we have about this disease related to the proteins expression and molecular

phisiopathology.

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The proteins and the medical utility has been growing up the last days, binding the diagnosis to the molecular dianas of the principally proiteins involved in the Alzheimer disease and others neurological pathologies.

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• The caracterization of this proteins will help us to dilucidate the importance of this proteins in several pathologies that will guide the diagnosis and the treatment of the people with Alzheimer disease.

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Specific biomarkers to make a correct diagnosis can be formulated concrete ways to prevent and treat in a better way this type of pathology

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• Today we have a very wide range of laboratory tests. These are now essential tools in basic and clinical research, the study and explanation of various functions and cellular processes and even in research of diseases such as Alzheimer's diseases and cancer.

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REFERENCES.

•Delvaux E, Bentley K, Stubbs V, Sabbagh M, Coleman PD, Differential processing of amyloid precursor protein in brain and in peripheral blood leukocytes.Neurobiol.Aging 2013 Jan 5. 21:89-97.

•Manzine R, França JM, Barham E, Assis J, Vale C, Sobreiro H, et al.ADAM10 as a Biomarker for Alzheimer Disease: A Study with Brazilian Elderly. Dement Geriatr Cogn Disord 2013;35:58–66.

•Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E: Alzheimer disease. Lancet 2011; 377: 1019–031.

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Alzheimer with his co-workers Nervenklinik Munich 1909-1910.