2. Worldwide Coverage of the Regenerative Medicine Proteus
Offices Scientific Advisors University Affiliations Conference
Presentations Professional Organizations CONFIDENTIAL 2
3. The Proteus Network: 7 Major Components A deep network
generates early access to breakthrough technology &
innovation
4. Leveraging Key Opinion Leaders US * * * * * * * * Core team
or scientific advisory board member from these institutions
5. Leveraging Key Opinion Leaders ROW * * * * Core team or
scientific advisory board member from these institutions
6. Professional Organizations & Advocacy Groups * * * * *
Core team or advisory board member part of these organizations
7. Conference Presentations / Publications 84 speaking
engagements worldwide at leading academic and professional
conferences over the past 3 years (core Proteus team) Core team and
Advisors are peer reviewers in virtually all the major RM Journals:
Biomaterials, Blood, Cell + Cell Stem Cell + Cloning and Stem Cells
+ JAMA + Journal of Biomedical Materials + Journal of Experimental
Medicine + Journal of Orthopedic Research + Journal of Tissue
Engineering and Regenerative Medicine + Nature + Nature
Biotechnology + Nature Medicine + Nature Reviews Drug Discover +
NEJM + PLOS-Biology + PLOS-Medicine + PNAS + Regenerative Medicine
+ Science + Stem Cells and Development + Tissue Engineering Core
team and advisors contributed directly to the following
publications: Books Principles of Tissue Essentials of Stem Cell
Handbook of Stem Cells Engineering Biology Stem Cells Now The
Immortal Cell Stem Cells in Drug Discovery Stem Cells: Bench to
Advances in Tissue Surfaces and Interfaces for Bedside, Engineering
Biomaterials Reports Advance cell & Tissue Therapies - A
mission to the US, Guidance on Standards on methods and regulation
for cell-based therapeutics (British Standards Institute)
Regenerative Medicine Terminology (British Standards
Institute)
8. Leverage Deep Domain Expertise of Partners Cell Processing
US & EU and CRO / CMO Jon Rowley, David Smith & Kim Warren
Intellectual Property & Legal Vern Norviel, Patent Attorney
Robert Preti, Stewart John Robinson, CEO Craig, Lee Buckler Chip
Lion & David Riley: Fund Counsel Matt Vincent, Patent Attorney
RM Specific James Lawford-Davies Consulting Steve Bengston Tom
Keelin & Michael Reeds: Decision Analysis & Asset
ValuationBarry Frankel & Devyn Smith: Life Science & RM
Regulatory RM Business Consultants Advice Sofi Fexby, Pierre
Maillet & John Watkins Shankar Seetharaman, CEO Peter Johnson
Darin Weber: FDA & Regulatory Issues (CBER) CONFIDENTIAL 8
9. Leverage Venture Capital Relationships CONFIDENTIAL 9
10. Leverage Proteus Proprietary Databases Three Core
Databases: RM Companies, Academic Research, IP
11. AppendicesDetails of Proteus Network of Relationships and
Publications1. Academic & Research Organizations: US and ROW2.
Professional Organizations & Advocacy Groups3. Funding and
Regulatory Agencies4. Conference Presentations and
Publications
12. Academic & Research Organizations: US Team
ContactsOrganization ContactBrown University Michael LysaghtBurnham
Institute for Medical Research Evan SnyderChildrens Hospital
Oakland Research Institute Bertram LubinColumbia University Silviu
ItescuDuke University Nelson Chao, Diane Kurtzberg, Bob TaberEmory
University Edmund WallerHarvard University George Daley, Brock
Reeves, David Scadden , Amy Wagers, Charles VacantiJohns Hopkins
University Gary Brocker, Doug Kerr, Aristides Melissaratos, Jeff
RothsteinMassachusetts Institute of Technology (MIT) Myron Spector,
Lita Nelsen, Ioanis Yannas, Robert Langer, Fiona MurrayMcGowan
Institute UPMC Alan Russell, Eric LagasseMD Anderson Cancer Center
Krishna Komanduri, Jeff MolldremMemorial Sloan Kettering Cancer
Center Malcolm MooreStanford University Amato Giaccia, Geoffrey
Gurtner, Michael Longaker, Irving WeissmanU of Texas: Texas Heart
Institute Paul Simmons, Emerson Perin, James WillersonUC San
Francisco Arnold Kriegstein, Yerem Yeghiazarian, Emmanuel
PassagueUniversity of Florida-Gainesville Dennis
SteindlerUniversity of Michigan Steve Feinberg, Wayne Harvey, Sean
MorrisonUniversity of Pennsylvania George Cotsarelis,University of
Washington Shelly Heimfeld, Don Thomas, Reiner Storb, Phil
GreenbergUniversity of Wisconsin-Madison Jamie Thompson, Gabriela
Cezar, Lynn Allen-HoffmannWake Forest University Anthony Atala
13. Academic & Research Organizations: ROW Team
ContactsOrganization Contact Organization ContactA*Star (Singapore)
Alan Colman University College of London (UK) Chris MasonBabraham
Institute (UK) Wolf Reik University of Cambridge (UK) Roger
Pederson, Azim SuraniImperial College London (UK) Julia Polak
University of Edinburgh (UK) Ian WilmutKings College London (UK)
Stephen Minger University of Oxford (UK) Paul FairchildMonash
University (Australia) Richard Boyd University of Southampton (UK)
Richard OreffoThe University of Nottingham (UK) Kevin Shakesheff
University of Toronto (Canada) Gordon Keller, Vince Tropepe Yair
Reissner, Yoav Soen,The University of Sheffield (UK) Peter Andrews
Weizmann Institute of Science (Israel) Tzvi Lapidot
14. Professional Organizations & Advocacy
GroupsOrganization Team Involvement Advisory Board, Finance
Committee, Industry Committee, GlobalInternational Society of Stem
Cell Research (ISSCR) Forum (Organizer)International Society for
Cellular Therapy (ISCT) Commercialization CommitteeTissue
Engineering & Regenerative Medicine Society International
(TERMIS) Past President Working Relationship (Alan Lewis, Dick
Ensel, Robert Goldstein, JuliaJuvenile Diabetes Research Foundation
Greenstein, Peter Lomedico, Charlie Queenan)Harvard Stem Cell
Institute Executive DirectorStem Cell Network (Canada) AdvisorUK
National Stem Cell Network (UKNSCN) Founder, Steering CommitteeEast
of England Stem Cell Network (UK) FounderLondon Regenerative
Medicine Network (LRMN) (UK) Founder/CEO/TrusteeCentre of
Excellence for Life Sciences Newcastle (UK) AdvisorMinistry of
Defence, Defence Society and Technology Laboratory (UK) AdvisorUK
Department of Health UK Stem Cell Initiative
Consult/Contributor
15. Funding and Regulatory AgenciesAgency ContactsUSAFDA - CBER
Donald Fink, Celia Witten, Steven BauerCalifornia Institute for
Regenerative Medicine Alan Trounson, Robert KleinNational
Institutes of Health Ron McKay, Jefferey BarkerUKMHRA (UK) Jeremy
Tinkler, Chris Bravery Mike Low, Regenerative Medicine Standards
CommitteeBritish Standards Institute (BSi) (PAS 83/84)LGC (formerly
Laboratory of the Government Chemist) Julian Braybrook, Neil
HarrisNational Physical Laboratory (NPL) Kamal Hossain, Mark
Bailey, Markys Cain, Peter TomlinsUK Stem Cell Bank (Nat. Instit.
for Biological Stds + Control [NIBSC]) Glyn Stacey, Charles Hunt,
Lyn Healy
16. Conference PresentationsConference Year(s) Team
InvolvementAmerican Society of Bone Marrow Transplantation (ASBMT)
2005-2008 Member, SpeakerAmerican Society of Hematology (ASH)
2005-2008 Member, SpeakerBIO International Convention 2007, 2008
SpeakerbioprocessUK Conference 2006 SpeakerBioproduction 2006 2006
Keynote speakerCambridge University Technology and Enterprise Club
(CUTEC) Technology Ventures 2007 Panel MemberConferenceCommercial
Translation for Regenerative Medicine 2007 Organizer, Keynote
Speaker, Scientific Advisory Board + Meeting ChairCommercialisation
of Tissue Engineering & Regenerative Medicine Conference 2005
Conference Chairman, Scientific Advisory PanelCommercialization of
Tissue Engineering and Cell Therapy 2006, 2007 Event Chair and
adviserCongress of International Drug Discovery Science and
Technology (IDDST) 2007 Scientific Advisory BoardESACT-UK Annual
Meeting 2006 Session Chairman and organiserEU Marie Curie
Conference 2007 Organising Committee 2006, 2007, Originator,
Organizer, Keynote Speaker, Scientific Advisory Board +European
Stem Cell & Regenerative Medicine Congress 2008
ChairmanEuroSciCon 2005 SpeakerGenesis Conference 2005 Session
Chairman, Advisory PanelInternational Stem Cell Conference 2007
Speaker
17. Conference PresentationsConference Year(s) Team
InvolvementISCT Annual Meeting 2007, 2008 SpeakerISSCR Annual
Meeting 2007 SpeakerKellogg Business of Healthcare Conference 2008
SpeakerMedical Device Technology European Conference 2005 Guest
speakerNational Stem Cell Conference (UK) 2005 SpeakerNetherlands
Science & Technology Conference 2006 SpeakerPhacilitate Cell
& Gene Therapy Forum 2008 SpeakerStem Cells & Regenerative
Medicine Conference 2006, 2007 Speaker 2005, 2006,Stem Cells &
Regenerative Medicine Congress Speaker 2007STEPS: Stem Cell Therapy
as an Emerging Paradigm in Stroke 2007 KeynoteStrategies for
Engineered Negligible Senescence (SENS) 2007 Session ChairThe
International Conference on Advanced Laser Technologies 2003
SpeakerThe Stem Cell Congress 2007, 2008 SpeakerTissue Engineering
& Regenerative Medicine Society International (TERMIS) 2007
SpeakerWorld Congress on Regenerative Medicine 2007 Organizer,
Keynote Speaker, Advisory Board, Session ChairWorld Stem Cell
Summit 2007 Speaker
18. Conference PresentationsWorkshops/Symposia Year(s) Team
InvolvementAdvanced Medical Technologies Enterprise Florida
(eFlorida) Mission to UK 2006 Session ChairAnatomical Society of
Great Britain & Ireland Summer Meeting 2007 SpeakerBA Festival
of Science 2006 SpeakerBBSRC The Cell Supply Chain Workshop 2005
Conference co-organizer and Session ChairmanBIA Roundtable 2007
SpeakerBioIndustry Association (BIA) Regulatory Affairs Committee
(RAAC) 2006 Session ChairbioLogic USA 2005 SpeakerBionanotechnology
and Tissue Engineering Meeting 2003 SpeakerBIOS (Research Centre
for the study of Bioscience, Biomedicine, Biotechnology and 2007
SpeakerSociety) Public DebateBrainy Brave New World public meeting
2007 Panel MemberBritish Standards Institute/Department of Trade
and Industry Workshop 2005 Co-organizer and ChairmanBritish-Russian
Workshop in association with the European Commission on Stem Cells
2007 Advisor, SpeakerCheltenham Science Festival 2007 Panel
MemberCross Council Stem Cell Programme Grant-holders Workshop 2006
SpeakerDTI funded Global Watch Mission, Advanced Cell & Tissue
Therapies - a mission to the 2006 SpeakerUSEconomic and Social
Research Council (ESRC) Stem Cell Programme 2007 SpeakerIChemE -
Biochemical Engineering Subject Group 2006 SpeakerLondon
Biotechnology Network Workshops 2006 Event Chairman and
adviserLondon Technology Network Workshops 2007 Session
ChairMcGowan Institute Retreat 2007 Speaker
19. Conference PresentationsWorkshops/Symposia Year(s) Team
InvolvementMid-Atlantic Bio, Stem Cell Track 2007
SpeakerPresentation to National Physical Laboratories and LGC
(Laboratory of the Government 2004 SpeakerChemist)Regenerative
Medicine Workshop - UK-Medicon Valley Bioscience Collaboration 2007
Session ChairRolduc International Polymer Meeting (European Polymer
Federation) 2003 Keynote speakerRoyal Institution of Great Britain,
Friday Evening Discourse 2007 SpeakerSilicon Valley Chapter of the
National Association of Corporate Directors 2008 Moderator &
SpeakerStem Cell Manchester 2007 Speaker + panel memberStem Cell
Roundtable, Science and Innovation 2007 SpeakerStem Cells for
Tissue Engineering and Regenerative Medicine to Policy 2006
SpeakerStem Cells in Orthopaedics Meeting 2005 SpeakerSymposium in
Stem Cell Repair and Regeneration 2006, 2007 Session Chair +
Co-organizerThe 2007 Hunterian Lecture 2007 SpeakerThe Stem Cell
Partnering Series 2008 SpeakerThe Stem Cell Summit 2007 SpeakerThe
Wolfson Centre for Age-Related Diseases and the Kings College
London Stem Cell 2005 SpeakerConsortiumTissue Engineering And
Regenerative Medicine Workshop 2004 SpeakerTissue Engineering
Meeting, DTI Texas-UK Collaborative Bioscience Initiative 2005
PresenterUCL Lunch Hour Lecture 2007 SpeakerUK Focus for Biomedical
Engineering Committee (hosted by the Royal Academy of 2007
SpeakerEngineering)University of Sydney/UCL Frontiers of Knowledge
Symposium 2007 Speaker
20. PublicationsPublication Team and Advisors
InvolvementRegenerative Medicine (Journal) Founder, EditorTissue
Engineering (Journal) Editorial BoardPrinciples of Tissue
Engineering, 2nd Edition (Lanza, et al.) Contributing
EditorEssentials of Stem Cell Biology (Lanza, et al.) Contributing
EditorHandbook of Stem Cells, Volumes 1 & 2 (Lanza, et al.)
Contributing EditorStem Cells Now (C.T. Scott) AuthorThe Immortal
Cell (M.D. West) AuthorThe Proteus Effect (A. Parsons)
ContributorStem Cells: Bench to Bedside (Bongso & Lee)
Contributing AuthorAdvanced cell & tissue therapies - A mission
to the US (DTI Global Watch Mission Report) (C. Mason, et al.)
Editor, Co-AuthorPAS 83 - Guidance on standards, standardised
methods and regulation for cell-based therapeutics, from basic
Co-Authorresearch to clinical application (British Standards
Institute)Advances in Tissue Engineering (J. Polak, ed.)
Contributing AuthorSurfaces and Interfaces for Biomaterials (P.
Vadgama, ed.) Contributing AuthorStem Cells in Drug Discovery:
Applications as Tools and Targets (C. Mason, et al.) Co-AuthorPAS
84 - Regenerative Medicine Terminology (British Standards
Institute) Co-AuthorVarious Peer Reviewed Publications Including
Cell, Science, PLoS and others
21. PublicationsScientific Journals Peer Review Participation
(Team and Advisors):Biomaterials Nature BiotechnologyBlood Nature
MedicineCell Nature Reviews Drug DiscoveryCell Stem Cell New
England Journal of MedicineCloning and Stem Cells PLOS-BiologyJAMA
PLOS-MedicineJournal of Biomedical Materials PNASJournal of
Experimental Medicine Regenerative MedicineJournal of Orthopedic
Research ScienceJournal of Tissue Engineering and Regenerative
Medicine Stem Cells and DevelopmentNature Tissue Engineering