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Public/Private Partnerships in Neuroscienceand
The George & Ann Ryan Neuroscience Institute
Interdisciplinary Neuroscience Program
Neuroscience
Understanding the mysteries of the brain and the nervous system—is a top priority
From seeking cures for neurodegenerative and neurological diseases
and disorders
to addressing mental illness, drug addiction, and substance abuse and developing effective treatments for brain injuries…
neuroscience has emerged as a compelling scientific & medical
frontier
Interdisciplinary Neuroscience Program
Neuroscience
• accounting, finance, management, marketing, and supply chain management
require the science of decision-making
• the study of business decision-making has slowly begun to mold itself to
the study of neuroscience (or, more specifically, neuroeconomics) • With mouse-click data in marketing and tick-by-tick transaction
data from the financial markets it is now practical and competitive to study the extent to which emotion contributes to the assessment of subjective value
Interdisciplinary Neuroscience Program
What is Alzheimer’s Disease?
• Most common form of dementia• 5 million are living with the disease
in the US (1 in 9 over 65)• 36 million globally• 95% are sporadic; late onset (LOAD)• 5% are genetic; early onset before
age 60 (EOAD)• 6th leading cause of death• No known cure
Modified from: http://southernbourbonmountains.blogspot.com 2013_11_01_archive.html
Interdisciplinary Neuroscience Program
Percentage Changes in Selected Causes of Death 2000 - 2010
Cause of Death
Alzheimer’s Disease
Stroke Prostate Cancer
Breast Cancer
Heart Disease
HIV
(Alzheimer’s Association, 2013 Alzheimers Dement)
500,000 may die each year, making AD the THIRD leading cause of death. Rush University Medical Center, March, 2014
Interdisciplinary Neuroscience Program
Projected number of people above 65 with AD
Interdisciplinary Neuroscience ProgramInterdisciplinary Neuroscience Program
VISION: Make Rhode Island the Leading State in
Neuroscience ResearchConnect URI, Lifespan, RIH and Brown to form an effective network that makes neuroscience the major focus of biomedical research in RI
Seek private and federal funding to establish a continuum of research from the bench to the bedside
Complement URI’s strength (drug discovery, engineering, and psychology) with Brown’s established neuroscience program and the clinical capability of RIH and Lifespan
Offer solutions for neurodegenerative diseases and CNS disorders
Interdisciplinary Neuroscience Program
The George & Ann Ryan Neuroscience Institute
The George & AnneRyan Institute forNeuroscience—
EstablishedNovember 14, 2013by Tom and Cathy
Ryan with theirgenerous gift of
$15 million dollars,the single largestcharitable gift inthe University ofRhode Island’s
Interdisciplinary Neuroscience Program
Physical Space (Institute)
Student Fellowships
Thematic Faculty Cluster Hires
Renowned Director
Funds: pilot studies, seed grants, startup, staff
Building Blocks
*Institute Staff (coordinator, clerical etc.)
Interviews in Progress
4 awarded
Interdisciplinary Neuroscience Program
Discovery
SynthesisExperimentation
Screening
Preclinical
Animal testingIn vitroIn vivo
Development
Clinical Trials
Products
DrugsDevices
University of Rhode Island Brown University
Norman Price Neuroscience InstituteRIH-Lifespan
Neurodegenerative Diseases, other CNS Disorders
INPGARIN
COBREBIBS
Diagnosis Formulations Devices Assays Imaging Treatment Prevention
Basic and Cognitive NeuroscienceCell and Molecular Biology
NeurobiologyClinical studies
CISND
Diagnosis and Treatment of Neurological DisordersCell and Molecular Biology
PharmacologyToxicology
Engineering Automation
PsychologyNursing
Neurobiology
Figure 2. Neuroscience Research in RI.
Statewide Approach
Interdisciplinary Neuroscience Program
Rhode Island Neuroscience Collaborative (RINC)
An enterprise developed by the Interdisciplinary Neuroscience Program at URI, the Brown Institute for Brain Science and the Norman Prince Neurosciences Institute to encourage and support new inter-institutional research collaborations in the neurosciences In June 2014 five projects that showed promise were funded through RINC and other processes
Each project is led by one Co-Principal Investigator from URI and one Co-Principal Investigator from Brown/RIH
THANK YOU FOR LISTENING!