Pumps and Pipes:Medical Imaging

King Li, MD, FRCP(C), MBAM D Anderson Distinguished Chair, Department of Radiology

The Methodist Hospital, Houston, TX

Professor of Radiology, Weill Medical College of Cornell University

Beginning of Medical Imaging

   

  

                                  

                                  

                                  

Copyright © 2000 by National Academy of Engineering. All rights reserved. Contact Us

1. Electrification2. Automobile3. Airplane4. Water Supply and Distribution

5. Electronics6. Radio and Television7. Agricultural Mechanization8. Computers9. Telephone10. Air Conditioningand Refrigeration

     

11. Highways12. Spacecraft13. Internet14. Imaging15. Household Appliances

16. Health Technologies

17. Petroleum andPetrochemical Technologies

18. Laser and Fiber Optics

19. Nuclear Technologies

20. High-performance Materials

Greatest Engineering Achievements of the 20th Century

Positron Emission Tomography Interventional Radiology

Computed Axial Tomography Ultrasonography

Magnetic Resonance ImagingDigital Radiography and Angiography

Modern Medical Imaging

Imaging: The Virtual Fantastic Voyage

Jain RK,Carmeliet PF.Sci Am 2001;285:38-45.

Computational Fluid Dyanamics

Longitudinal Study of Tumor Growth

Tumor growth

2 years

0.5

0.5

0.5

0.5

Data courtesy: fBIRN, Stanford-Lucas Center and Harvard-MGH Martino Center

Functional Neuroimaging

Kantarci et al., in press, Nature Genetics, 2007

Mutations in megalin, a multi-ligand receptor, cause Donnai-Barrow/ FacioOculoAcousticoRenal (DBS/FOAR) syndrome

Multi-scale Neurological Profiling

Imaging Probes

Weissleder R. Nature Reviews/Cancer 2002;2:1-8

Interventional Medicine of the Future:One Seamless Integrated Iterative Platform

Targeted Treatment Plan

Navigation

Visualization

Robotic needle placement

Feedback loop

MonitoringCompare to pre-tx plan

Feedback loop

Treatment PlanUpdate

•30 cycles

•On: 90 msec

•Off: 1910 msec

•Power: 20.5 Watts/cm2

•150 cycles

•On: 90 msec

•Off: 1910 msec

•Power: 20.5 Watts/cm2

Control Treated

Control TreatedYuh EL, et al. Radiology 2005;234:431-7.

Identify Targets

Drug DeliveryIn vivo drug delivery

Drug DeliveryIn vivo drug delivery

BiochemistryCulture assays, kinetic models

BiochemistryCulture assays, kinetic models

Computing / Database & Biostatistics

3D models

Computing / Database & Biostatistics

3D models

GenomicsProteomics

GenomicsProteomics

ChemistryChemical probes and reagents

ChemistryChemical probes and reagents

Molecular BiologyMolecular Biology

ImmunologyFACS analysis

ImmunologyFACS analysis

BiochemistryHistopathology

BiochemistryHistopathology

GenomicsProteomics

GenomicsProteomics

Computing / Database & Biostatistics

Data management and analysis

Computing / Database & Biostatistics

Data management and analysis

Molecular BiologyReporter constructs

Molecular BiologyReporter constructs ImagingImaging Engineering

Hardware/software

EngineeringHardware/software

EngineeringHardware/software

EngineeringHardware/software

New diagnostic and therapeutic methods

Li KC. Acad Radiol 2002;9:999-1003.