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Pyrazole-oxadiazole Conjugates: Synthesis, Antiproliferative
Activity and Inhibition of Tubulin Polymerization
Ahmed Kamal,
*[a,d] Anver Basha Shaik,
[a] Sowjanya Polepalli,
[b] Vangala Santosh Reddy,
[a]
G. Bharath Kumar,[a]
Soma Gupta,[a]
K.V.S. Rama Krishna[c]
Ananthamurthy
Nagabhushana,[e]
Rakesh K Mishra,[e]
Nishant Jain[b]
aMedicinal Chemistry and Pharmacology, CSIR ‒ Indian Institute of Chemical Technology, Hyderabad 500
007, India bCentre for Chemical Biology CSIR-Indian Institute of Chemical Technology Hyderabad 500 007, India
cNuclear Magnetic Resonance Centre CSIR-Indian Institute of Chemical Technology Hyderabad 500 007, India dDepartment of Medicinal Chemistry National Institute of Pharmaceutical Education and Research (NIPER),
Hyderabad-500 037, India eCSIR ‒ Centre for Cellular and Molecular Biology, Hyderabad‒500 007, India
*Correspondence: [email protected]; Phone: (+) 91-40-27193157; Fax: (+) 91-40-
27193189.
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry.This journal is © The Royal Society of Chemistry 2014
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1H NMR and 13C NMR spectra of conjugate 11a:
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1H NMR and 13C NMR spectra of conjugate 11b:
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1H NMR and 13C NMR spectra of conjugate 11c:
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1H NMR and 13C NMR spectra of conjugate 11d:
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1H NMR and 13C NMR spectra of conjugate 11e:
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1H NMR and 13C NMR spectra of conjugate 11f:
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1H NMR and 13C NMR spectra of conjugate 11g:
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1H NMR and 13C NMR spectra of conjugate 11h:
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1H NMR and 13C NMR spectra of conjugate 11i:
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1H NMR and 13C NMR spectra of conjugate 12a:
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1H NMR and 13C NMR spectra of conjugate 12b:
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1H NMR and 13C NMR spectra of conjugate 12c:
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1H NMR and 13C NMR spectra of conjugate 12d:
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1H NMR and 13C NMR spectra of conjugate 12e:
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1H NMR and 13C NMR spectra of conjugate 12f:
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1H NMR and 13C NMR spectra of conjugate 12g:
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1H NMR and 13C NMR spectra of conjugate 12h:
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1H NMR and 13C NMR spectra of conjugate 12i:
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1H NMR and 13C NMR spectra of conjugate 17a:
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1H NMR and 13C NMR spectra of conjugate 17b: