QUASIX®: Clinical Evidences QUASIX®
Overall improvement at the end of study
The results after 6 weeks treatment are online with those after 3 month published for topical
Metronidazole and Azelaic acid.
At Baseline
After 45 days treatment
with QUASIX®
3 Products adapted to your patients’ needs
Anti-Redness Cream- Dry and Mixed SkinIndications:Diffuse or permanent redness on the face.Moderate to intense rosacea.Instructions for use:Apply a slight layer of cream twice a day on the area to be treated on dry and cleanskin. Once the cream is well-absorbed, makeup is possible.Presentation: Tube 30ml
Anti-Redness Gel - Oily SkinIndications:Diffuse or permanent redness on the face.Moderate to intense rosacea.Instructions for use:Apply a slight layer of gel twice a day on the area to be treated on dry and cleanskin. Once the cream is well-absorbed, makeup is possible.Presentation: Tube 30ml
Protective Anti-Redness Cream SPF30Indications:Diffuse or permanent redness on the face.Moderate to intense rosacea.Must be used by daytime. High sun protection factorInstructions for use:Apply a slight layer of cream before each sun exposure on the area to be treated on dry and clean skin. Once the cream is well-absorbed, makeup is possible.
Presentation: Tube 30ml
QUASIX CremaWater (Aqua), Quassia Amara Wood Extract, Caprylic/Capric Triglyceride, Coco-Caprylate/Caprate, Glycerin, Cetearyl Isononanoate, Dicaprylyl Carbonate, Glyceryl Stearate,Niacinamide, Cetearyl Glucoside, Cetearyl Alcohol, Squalane,Titanium Dioxide (CI 77891),Xanthan Gum, Carrageenan (Chondrus Crispus), Dehydroacetic Acid, Benzyl Alcohol,Disodium EDTA, Ethylhexylglycerin, Chromium Oxide Green (CI 77289)
QUASIX GelWater (Aqua), Quassia Amara Wood Extract, Propylene Glycol, Niacinamide, Carbomer,Xanthan Gum, Sorbic Acid, Phenoxyethanol, Benzyl Alcohol, Disodium EDTA,Sodium Hydroxide, Allantoin, Chromium Oxide Green (CI 77289)
QUASIX SPF30Water (Aqua), Quassia Amara Wood Extract, Titanium Dioxide, Dibutyl Adipate,Caprylic/Capric Triglyceride, Ethylhexyl Palmitate, Zinc Oxide (CI 77947) Glycerin,Sorbitol, Cetearyl Alcohol, Niacinamide, Cetearyl Glucoside, Phenoxyethanol,Dimethoxydiphenylsilane/Triethoxycaprylylsilane Crosspolymer, Hydrated Silica,Aluminum Hydroxide, Xanthan Gum, Benzyl Alcohol, Dehydroacetic Acid,Disodium EDTA, Chromium Oxide Green (CI 77289)
www.quasix.com
Your innovative responsein the management of rosacea
®Quasix
QUASSIA (Quassia amara) extract is a strong antiparasitic10, antimicrobial, antiinflammatory11 and antioxidant.
NICOTINAMIDE (Vitamin B3) shows potent inhibitory effects on the expression of proinflammatory cytokines (IL-1ά, IL-6, IL-8…)12 but also on matrix metalloproteinases activity13 and ICAM-1 expression14.
NICOTINAMIDE has a stabilizing effect on epidermal barrier function by: -Reducing the Trans-Epidermal Water Loss (TEWL)15
-Improving the moisture content of the horny layer15
-Stimulating the ceramide synthesis16
Vegetal GLYCERIN, a skin-friendly humectant attracting water to the skin; helping maintain the water balance in the intercellular matrix and strengthening the skin barrier.
SORBITOL, a sugar-based ingredient, helps maintain skin-hydration and prevents moisture loss
PH 5.5 OF THE PRODUCTS IS IDEAL TO MAINTAIN INTEGRITY OF SKIN BARRIER17
Results
Mean Flushing Score along study Mean Erythema Score along study
Mean Telangiectasia Score along study Mean Papules Score along study
Mean Pustules Score along study
The etiology of rosacea remains unknown; rosacea is most probably a multifactorial condition1. Structural alterations of cutaneous vasculature2 with increased angiogenis3, under influence of increased expression of factors of angiogenesis and adhesion molecules (VEGF, ICAM-1)4,5 are commonly admitted causes for rosacea. Impaired epithelial barrier function6 is also involved as a causative factor for rosacea.
The role of Demodex folliculorum, although not well-defined, is beyond any discussion7. It could be responsible for the excessively high level of various cyto kines (IL-1ά, IL-8…)8
and matrix metalloproteinases9 observed in
rosacea, and responsible for the inflammatory pattern.
®Quasix ®Quasix
®Quasix
QUASIX®:
An efficient combination of four natural active ingredients
DR. ALICIA FERRARI, Córdoba, Argentina.
Study designMonocentre, controlled, intraindividual study.
Study Population: 30 patients >18 years.
Study ProtocolDuration 6 weeks (45 days) - QUASIX® twice per day.Patients evaluated at baseline plus follow-up evaluations at D15, D30 and D45.Assessment of:- Flushing (0=none, 1=intermittent, 2=permanent, 3=severe)- Erythema (0=none, 1=mild, 2=moderate, 3=severe)- Telangiectasia (0=none, 1=mild, 2=moderate, 3=severe)- Papules (0=none, 1=<5 papules, 3=>5 and <20 papules, 4= >20 papules)- Pustules (0=none, 1=<5 pustules, 3=>5 and <20 pustules, 4= >20 pustules)
ROSACEA QUASIX®: Clinical Evidences
BIBLIOGRAPHY
1. Blount WB. Pelletier M.P.H. & Al.Rosacea: A Common,Yet Commonly Overlooked Condition. Am Fam Physic. 2002; 66(3):435-440.2. Dahl M.V. Pathogenesis of Rosacea. Adv. Dermatol. 2001;17:29-45.3. Crawford GH, Pelle MT, James WD. Rosacea: 1.etiology, pathogenesis and subtype classification. J. Am Acad Dermatol. 2004;51:327-341.4. Gomaa AH, Yaar M, Eyada MM, Bhawan J. Lymphangiogenesis and angiogenesis in nonphymatous rosacea. J. Cutan Pathol. 2007 Oct;34(10):748-535. Cuevas P, Arrazola JM.Therapeutic response of rosacea to dobesilate. Eur J Med Res. 2005 Oct 18;10(10):454-6.6. Dirschka T, Tronnier H, Fölster-Holst R. Epithelial barrier function and atopic diathesis in rosacea and perioral dermatitis. Br. J. Dermatol. 2004 Jun;150(6):1136-41.7. Hoekzema R et al. Democidosis or rosacea: what did we treat? Br. J. Dermatol. 133:294-9, 19958. Elssner A, Duncan M, Gavrilin M, Wewers MD. A Novel P2X7 Receptor Activator, the Human Cathelicidin-Derived Peptide LL37, Induces IL-1_ Processing and Release. J. Immunol. 2004;9. Bonamigo RR, Bakos L, Edelweiss M, Cartell A. Could matriz-metalloproteinase-9 be a link between Demodex folliculorum and rosacea? J. Eur Dermatol Venereol 2005;19(5):646-647.10. Jensen O, Nielsen AO, Bjerregaard P. Pediculosis capitis treated with Quassia tincture. Acta Derm Venereol 58(6):557-559. 1978.11. Toma W, Gracioso JS, Hiruma-Lima CA, Andrade FDP, Vilegas W, Souza Brito ARM, Evaluation of the analgesic and antiedematogenic activities of Quassia amara bark extract. J.Ethnopharmacol 85 (2003) 19-23.12. Ungerstedt JS, Blombäck M, Söderström T, Nicotinamide is a potente inhibitor of proinflammatory cytokines. Clin Exp Immunol. 2003; 131:48-52.13. Dragun P, Makarewicz D, Wöjcik L, Ziemka-Nalecz M, Slomka M, Zalewska T. Matrix-metalloproteinases activity during the evolution of hypoxic-ischemic brain damage in the immature rat. The effect of 1-methylnicotinamide (MNA). J Physiol Pharmacol 2008;59(3):441-455.14. Hiromatsu Y, Sato M, Tanaka K, Ishisaka N, Kamachi J, Nonaka K. Inhibitory effects on intercellular adhesion molecule-1 expression on cultured human thyroid cells. Immunology 1993; 80:330-332.15. Soma Y, Kashima M, Imaizumi A, Takahama H, Kawakami T, Mizoguchi M. Moisturizing effects of topical Nicotinamide on atopic dry skin. Int J Dermatol. 2005; 44:197-202.16. Tanno O, Ota Y, Hikima R, Matsumoto M, Ota M, Inoue S. An increase in endogenous epidermal lipids improves skin barrier function. XXI IFSCC International Congress, Berlin 2000.17. Schmid-Wendtner mh, Korting HC. The pH of the skin surface and its impact on the barrier function. Skin Pharmacol Physiol 2006; 19:296-302.
Evolution of Telangiectasias
00,20,40,60,8
11,21,41,61,8
D0 D15 D30 D45
Days
Tela
ngie
ctas
ias
Scor
e
Serie1