Date post: | 01-Jan-2016 |
Category: |
Documents |
Upload: | riley-clarke |
View: | 109 times |
Download: | 3 times |
RABIES VIRUSRABIES VIRUS
What’s this?What’s this?
• Morphology and structure• Replication• Pathogenesis • Clinical symptoms• Diagnosis• Prevention and Treatment
Morphology Morphology • bullet-shaped; • 45-100 nm in diameter; 100-430 nm long.
structurestructure• Core -ssRNA• L-protein (large protein)• ---RNA dependent RNA polymerase RNP Capsid N-protein ---protect RNA from hydrolysis P-protein
Envelope Bilipid layer• M-protein (matrix protein)• G-protein (glucoprotein)• ---spike• ---bind to the receptor of the host cell•
• Rabies is an RNA virus. The genome encodes 5 proteins designated as N, P, M, G, and L. The order and relative size of the genes in the genome are shown in the figure below. The arrangement of these proteins and the RNA genome determine the structure of the rabies virus.
•
ReplicationReplication• Adsorption• Penetration• Uncoating• Biosynthesis• Assembly and release
biosynthesisbiosynthesis• -ssRNA• RNA polymerase
• +ssRNA
• -ssRNA protein• • virus
PathogenesisPathogenesis• CNS
afferent fibers efferent fibers nerve endings salivary glandNeuromuscular organs and tissuesjunction muscles Virus
Clinical symptomsClinical symptoms• Early stage (1-3days)• fever(37.5-38)• vomit• wound:pain,red,itching• Exciting stage(1-3days)• fever(39-40)• hydrophobia:pharyngeal muscle cramp,dyspnea• dehydration• Paralytic stage(15-20hs)• nerve fiber paralysis• respiratory and circulatory failure death
DiagnosisDiagnosis
• Pathogenic history• Isolating the dog(7-10days)
cerebral smear or slice immunofluorescent stain
Prevention and treatmentPrevention and treatment
• Kill wild dogs• Keep away from
dogs
• Clean the wound• Passive immunity• vaccine
ContributersContributers• Bian Shu• Cong Ping• Mu Xueru• Shao Cong• Zhang Jingjing• Zhu Wenying
• Cheng Wei• Hu Chen• Li Yuntao• Li Daowei• Wang Shengxi