Reaxys – Managing Complexity

September 2009

Manisha Murthy (m.murthy@elsevier.com)Product sales Manager, Corporate Accounts

What is Reaxys?

• Reaxys is• Chemistry

• Covering more than 200 years of organic, organometallic and inorganic chemistry• From journal articles and patents• Based on CrossFire Beilstein, CrossFire Gmelin and Patent Chemistry Database

• Intuitive• Easy to use web-interface, available anytime and anywhere without limits and

without installation needs• ChemAxon MarvinView (high quality structure display) and MarvinSketch (feature-

rich query editor supporting Reaxys specials) are instrumental here• Created from scientist for scientist

• The Workflow Solution• Supporting scientists in life science and chemistry in industry and academia in their

daily work• Providing decision support in finding relevant and validated chemical information • Helping to reduce time and efforts in building synthesis plans

2

Copyright © 2009 Elsevier Properties SA. All rights reserved. Reaxys® is owned and protected by Elsevier Properties SA and used under license.

3

Who develops Reaxys?

• Elsevier – A global company• 2008 Revenues: ca $3 billion – Science and Technology (~$1.5b) and Health Sciences (~$1.5b)• Sales in 180+ countries• 7,500 employees, 74 offices in 25 countries• Serving 30 million+ scientists, students, health and information professionals • 1,800 journals and 2,200 new books each year • Publishes 25% of world’s journal articles

• Elsevier Information Systems GmbH Frankfurt• Inventor of the CrossFire system• Producer of

• CrossFire Beilstein since 1993• Patent Chemistry Database from concept to release in 2005• and CrossFire Gmelin since 1996

Reaxys – Synthesis of compounds

• How can I make chloro-substituted Biphenyl-4-ols?• Draw the Query using ChemAxon MarvinSketch...

4

Select interest area for querying

Define query options

Reaxys – Synthesis of compounds

• How can I make chloro-substituted Biphenyl-4-ols?• Browse the result...

5

Graphical Breadcrumb Navigation

Experimental Text from patents

Filter-based refinement feature

Reaxys – Synthesis of compounds

• How can I make chloro-substituted Biphenyl-4-ols?• Plan the synthesis...

6

Commercial Availability Indicators

Reaxys – Properties of Compounds

• Where do I find NMR data of Sildenafil?• Create query structure using „Generate Structure from Name“

<add footer here via Master slide> May 10, 2009 ‹#›

Reaxys – Properties of Compounds

• Where do I find NMR data of Sildenafil?• Browse the result table

<add footer here via Master slide> May 10, 2009 ‹#› Context sensitive filters.

Here: compound data

Data available with a mouse click

Reaxys – Properties of Compounds

• Where do I find NMR data of Sildenafil?• Use „Zoom“ to see details of the structure with MarvinView...

Reaxys – Properties of Compounds

• Where do I find NMR data of Sildenafil?• Click „Spectra“ to see the details...

<add footer here via Master slide> May 10, 2009 ‹#›

Original peak details from patents

Reaxys – Output Features

• Supports various export formats• PDF• Microsoft Word• Microsoft Excel• XML• RD File• SD File• Smiles

• In selectable granularity• With or without structures• With all or selected data

• Link-In• Reaxys URL can be equipped with parameters

• OpenURL support• Reaxys Full Text linking supports inhouse literature resolving services (e.g. SFX

server)

Reaxys – Integration Features

Link-from Micrsoft Excel into Reaxys: http://www.reaxys.com/reaxys/secured/hopinto.do?context=R&query=SMILES='CCCCCC(=O)OC1=CC=CC=C1C(=O)OC'&qname=Asp2&options=product&ln=

What is Reaxys?

• Reaxys is

• Chemistry• Data rich content covering the full range of chemistry: organic, organometallic and

inorganic compounds

• Intuitive• Powerful yet easy-to-use

• Intuitive query formulation including Marvin Sketch as structure editor• Table-like results browsing for reactions, compounds and citations• Synthesis planner for tracing back synthesis paths• Feature rich export capabilities

• The Workflow Solution• Providing relevant information at a fingertip• Can be integrated in existing environments

13

Copyright © 2009 Elsevier Properties SA. All rights reserved. Reaxys® is owned and protected by Elsevier Properties SA and used under license.

Reaxys – Want to see more?

• Visit us @ http://www.info.reaxys.com