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Southwestern University - Matias H. Aznar Memorial College of Medicine Inc. Redemptorist Plaza, Camputhaw Cebu City
http://swumhamcollegeofmedicineyahoo.com
VISION
SWU-MHAM College of Medicine is a leading medical institution, anchored in excellence, committed to produce globally competitive medical
professionals, imbued with knowledge in research and community service.
MISSION
Provide state-of-the-art facilities;
Nurture a community of competent medical experts in all fields of specialization;
Strengthen a research- and evidenced-based learning;
To use information technology approach to teaching;
To enhance learning core competencies and skills training;
Strengthen the practice of community-oriented and universally-accepted health care;
To forge linkages/partnership with government and non-government agencies in the service of the community;
To provide opportunities for a medical career to economically challenged but deserving students;
To produce competent, compassionate, and committed physicians;
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GOALS
The MHAM College of Medicine Inc, Inc. offers the medical program leading to a degree of Doctor whose graduates are:
Trained in highest scientific and ethical standards of medical education
Responsive to the current health needs of the people in the community and globally
Updated with the latest therapeutic modalities and health related technologies
Proficient in the conduct of globally competitive medical research which is attuned to the prevailing health conditions in the community
In pursuit of lifelong disposition of professional advancement and learning
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Southwestern University - Matias H. Aznar Memorial College of Medicine Inc. Redemptorist Plaza, Camputhaw Cebu City
CORE VALUES
PROFESSIONALISM
We observe a polite behaviour and courteousness; adhere to a high sense of ethical standards in the performance of our duties and responsibilities in the work
place.
RESPECT
We act with deep admiration, giving due regards and high esteem to everyone.
ONENESS
We stand united in all our endeavours and uphold the good name, honour and integrity of the institution.
LEADERSHIP
We act as role model, do things that will work best in the institution and provide policy directions that are relevant to the needs of the time in order to fulfill our
ultimate
goals
INTEGRITY
We adhere to the highest ethical code of conduct in our dealings with others and exercise our duties and responsibilities with correlative obligation to preserve
human dignity.
FAIRNESS
We are impartial, reasonable, transparent and free from discrimination in the performance of our duties and responsibilities.
EXCELLENCE
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We pursue the highest standard of quality service in all program of engagements and undertakings for the attainment of the Vision and Mission of the institution
Southwestern University - Matias H. Aznar Memorial College of Medicine Inc. Redemptorist Plaza, Camputhaw Cebu City
Institutional Outcome
Program Outcome Course Outcome
A graduate of SWU-MHAM CM is expected to be a :
Upon completion of the MD program the graduate should be able to :
Upon Completion of Basic medical sciences. (Pharmacology) The student should be able to;
Proficient Physician who adheres to the highest ethical conduct in the care of patients, seasoned with communication and analytical skills
Demonstrate capability in the diagnosis and treatment of health conditions of people without discrimination with respect to their nationality, race, socio-economic status, gender, culture, beliefs and creed. (CHED 1,2,8,9,10) (SWU-MHAM Core Values 2, 6, 7)
Demonstrate competency and
effective communication skills in
discussing and explaining the
following :
The basic principle of
Medical Pharmacology
The standard classification
of drugs based on
intentionally accepted
nomenclature.
The basic principles of the
different pharmacologic
disciplines
The principles of
therapeutics, drug action
and interactions.
(CHED 1,2) SWU MHAM 2,6,7
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Leader who has exemplary moral values which are deeply anchored in his/her religious convictions and work best for the betterment of the community
Leads and manage health care teams in the community through utilization of an interdisciplinary approach, health information dissemination and adherence to ethical, professional, legal, national and international standards in the delivery of health care (CHED 3,5,8,9,10) SWU-MHAM Core Values 1,4,5,6
Effectively and Efficiently work
with other health professionals
especially in Collaborating in
PharmacoTherapeutic teams ,
community awareness forums and
research projects
(CHED 2,3,5,8,9,10)
(SWU MHAM 1,4,5,6)
Manager who has a good working relationship with people coming from different sectors in the community
Initiate planning, organizing, implementation and evaluation of healthcare programs using system- based approach, and observes the principles of social accountability. (CHED 5,6,7,10) (SWU-MHAM Core Values 1, 5)
Initiate Planning and Organizing a
Pharmacology symposium
Research forum
Review Committee for Essential Drugs
Community information awareness regarding the use and abuse of drugs, and alternative medicine .
(CHED 5,6,9,10 (SWU MHAM 1,5)
Researcher who can engage in innovative research activities and utilize research findings in improvement of health care delivery.
Adhere to the ethical standards in the conduct of research; communicate research findings and apply these findings to improve health care delivery. (CHED 2,4,6,8) (SWU-MHAM Core Values 1,5)
Utilizes research in
Investigating the various
endogenous medicinal
plants , their active
compounds, action,
mechanisms and effects
Correlating the concepts
and principles of Rational
Drug use and Evidence
Base pharmaco
therapeutics in a clinical
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Setting
(CHED 4,6,8)(SWU-MHAM 1,5)
Teacher who has deep dedication and passion to transfer knowledge and skills; and include values in the molding of medical professionals.
Engage oneself and inspire others to continue personal and professional development (CHED 7) (SWU MHAM M Core Values 1)
Facilitate a small group
discussion
Convey clear and relevant
information
In written and oral reports
on focused topics , case
studies utilizing different
types of audiovisual to
resources to their faculty
and to their fellow students
To patients regarding a
content and instructions in
a written prescription
(CHED 2) (SWU MHAM 1)
Update oneself by regularly
attending pharmacology and
Toxicology symposium, research
forum, Drug symposium and be
able to apply such knowledge for
his/her professional advancement
in order to educate patients and
deliver quality healthcare.
(CHED 7) (SWU MHAM 1)
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Nationalist who instills to the community and country
Demonstrate love for one’s countrymen, national heritage and culture (CHED 9) (SWU-MHAM Core Values 3)
Demonstrate a love of Filipino
heritage by:
Promoting our natural
plants that have medicinal
potential
Exhibiting an attitude of
service to our community
(CHED 9,10)(SWU-MHAM 3)
Adhere to national, international and legal standards in regulation of drugs (CHED 9,) (SWU-MHAM 3)
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Southwestern University - Matias H. Aznar Memorial College of Medicine Inc. Redemptorist Plaza, Camputhaw Cebu City
SYLLABUS IN
PHARMACOLOGY AND TOXICOLOGY
MEDICINE -2ND YEAR
I. Course Title: Pharmacology and Toxicology
II. Course Description: This course deals with the drugs and their mechanisms of action discussed at the cellular and
molecular level It also deals with proper identification and fundamental principles of action mechanisms relating to the
different branches such as pharmacognosy, pharmacokinetics, pharmacodynamics, pharmacotherapeutics, posology,
toxicology, pharmacogenetics, teratogenic pharmacology, and pharmacovigilance. Additionally, the students will be
trained to comprehend the subject with the end view of motivating them to explore vast and interesting field of
pharmacology.
III. Unit Credits 16 Units (8 units per semester) 7 hours per week
IV. Venue Audio visual room 2 and 3
V Entry Competencies Medical Students should have prior knowledge in Human Anatomy, Medical Physiology and
Biochemistry
VI Learning Outcomes: Following the Outcome based curriculum, Pharmacology and Toxicology will be geared
Towards making second year medical student achieve the following learning outcome
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VII. Course Objectives :
Students who have completed this course should be able to:
1. Demonstrate competency and effective communication skills in discussing and explaining the following :
1.1 The basic principle of Medical Pharmacology
1.2 The standard classification of drugs based on intentionally accepted nomenclature.
1.3 The basic principles of the different pharmacologic disciplines such as: pharmacokinetics, pharmacodynamics,
Pharmacotherapuetics and toxicology
1.4 The principles of drug action and interactions.
Learning outcomes Level of Emphasis
1. Demonstrate clinical competence Demonstrated
2. Communicate effectively Practiced
3. Lead and manage health care teams Practiced
4. Engage in Research Activities Practiced
5. Collaborate within inter-professional teams Introduced
6. Utilized systems based approached to healthcare Introduced
7. Engage in continuing personal and professional
development
Practiced
8. Adhere to ethical ,professional and legal standards Practiced
9. Demonstrate nationalism, internationalism and dedication
to service
Practiced
10. Practice the principles of social accountability Introduced
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2. Convey clear information
2.1. In written and oral reports on focused topics , case studies utilizing different types of audiovisual to resources to their faculty and to their fellow
students
2.2. To patients regarding a content and instructions in a written prescription
3. Initiate Planning and Organizing a
3.1 Pharmacology symposium
3.2 Research forum
4. Utilizes research in
4.1 Investigating the various endogenous medicinal plants , their active compounds, action, mechanisms and effects
4.2 Correlating the concepts and principles of Rational Drug use and Evidence Base pharmacotherapeutics in a clinical
Setting
5. Effectively and Efficiently work with other health professionals especially in Collaborating in research projects
6. Update oneself by attending
6.1 A pharmacology and Toxicology symposium
6.2 A research forum
6.3 Drug symposium
7. Adhere to national, international and legal standards in regulation of drugs
8. Demonstrate a love of Filipino heritage by:
8.1 Promoting our natural plants that have medicinal potential
8.2 Exhibiting an attitude of service to our community
9. Practice the principles and relevance of RATIONAL DRUG USE in the delivery of health care to the patient and to the community
10. Practiced the principles of social accountability by monitoring and reporting adverse effects and toxicity of drugs
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Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
At the end of the grading period, the
student should be able to:
1.1. Explain the development of
pharmacology as a science.
1.2. Discuss what is pharmacology, the
subdivisions of pharmacology and the
disciplines that interface with it.
UNIT I
INTRODUCTION OF
PHARMACOLOGY
1. History of
pharmacology
- The disciplines of
pharmacology
3.5 hours
-Lectures
-Small group
discussion
Textbook :
-Basic and -Clinical Pharmacology
-quizzes
-oral recitation
-unit examination
- group
participation and
communication
skills
-Short essays
-Posttest MCQ,
-Rating Scale with
rubric
-Embedded testing
incorporated into
assignments
-Minute paper
2.1. Explain and describe the physical
processes underlying drug kinetics.
2.2. Discuss the four mechanisms by
which small molecules (drugs) cross cell
membranes.
2.3. Analyze the process of binding of
drugs to plasma proteins.
2.4. Explain the effect of fats and other
tissues on the accumulation of drugs.
2.5. Discuss the process of drug
absorption according to the:
2.5.1. Major routes of drug
2.Pharmacokinetic of Drugs
a. Routes of administration
b. Different Pharmacokinetic
Processes
-absorption
-protein binding
-distribution
c. Routes of drug
3.5 hrs
-Lectures
-Small group
discussion
Textbook :
-Basic and -Clinical Pharmacology
-quizzes
-oral recitation
-unit examination
- group
participation and
communication
skills
-Short essays
-Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
12
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
administration.
2.5.2 Explain the different factors
affecting absorption through
gastrointestinal tract and other routes.
2.5.3. Analyze concepts of
bioavailability and bioequivalence.
2.6. Discuss the distribution of drugs in
the body:
2.6.1. Explain the four body fluid
Compartments and the concept of
Bloodbrain-barrier.
2.6.3.Discuss the concept of volume of
distribution.
2.7. Explain the special drug delivery
systems.
2.8. Explain the concept of first-pass
(pre-systemic) metabolism
2.9. Discuss Biliary excretion and
enterohepatic recirculation.
3.0 . Estimate the half life of a drug
based on it’s clearance and volume of
administration
d.Bioavailability
e. bioequivalence
f. Half Life
g.Enterohepatic recycling
h, Kinetics of drug absorption
i..Volume of Distribution
j. Drug clearance
k. Special drug delivery systems.
-Lectures
-Small group
discussion
Textbook :
-Basic and -Clinical Pharmacology
quizzes
-oral recitation
-unit examination
- group
participation and
communication
skills
-short essy
Quizez on
Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
analytical
13
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
distribution
3.1 Solve a case in patients with
impaired renal or liver requiring dosage
adjustment .
Textbook :
-Basic and -Clinical Pharmacology
problem solving
skills
problem-solving
assessment tools (
4.1. Discuss the process of drug
metabolism according to:
4.1.1. The two kinds of reactions (Phase 1 and Phase 2). 4.1.2 The concept pf stereo-selectivity 4.2. Explain the mechanism by which drugs inhibit the P450 enzymes or increase the activity of microsomal enzymes and oxygenating systems (induction) and identify the drugs that are inducers and inhibitors 4.3. Recognize and list the drugs that are affected by inducers and inhibitors 4.4. Predict the effect on drugs that are affected by an inducers or by an inhibitor 4.4. Present clinical cases of drug
induction , drug inhibition and drug
excretion
3. Biotransformation and Drug
Excretion
a. Type of drug metabolic
reactions
- PHASE 1 reactions
- PHASE 2reactions
b. Drug metabolizing enzyme
system
- Inducers
- Inhibitors
3.5 hours
-Lectures
-Small group
discussion
Textbook :
-Basic and -Clinical
Pharmacology
-quizzes
-oral recitation
-unit examination
- group
participation and
communication
skills
-short essay
Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
14
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
4.5. Explain the process of drug and metabolite excretion: 4.5.1. Discuss Renal excretion of drugs and metabolites. 4.6.Correlate clinical cases of drug
overdose with renal clearance
c. Renal excretion of drugs
- Factors affecting the renal
excretion of drugs
-renal clearance of basic drugs
-renal clearance of acidic drugs
5.1. Explain the four protein targets for
drug action receptors, ion-channels,
enzyme and transport proteins.
5.2. Discuss and differentiate among
the four types of receptors according to
location, effectors, and molecular
structure.
5.3.Classify drugs according to it’s
receptor type
5.4.Explain the control of receptor
expression.
5.5. Present clinical diseases linked to
receptor malfunction.
5. Receptors
a.Ligand gated / ion channel receptors b.G- protein coupled receptors c.Tyrosine kinase linked receptors d.Intranuclear / steroid
receptors
e.PPAR receptors
f. Receptor downregulation
g. Receptor upregulation
3.5 hrs
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
-Basic and -Clinical
Pharmacology
-Netters illustrated
Pharmacology
-quizzes
-oral recitation
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
-Posttest MCQ
-minute paper
-Essay questions
-Embedded testing
incorporated into
assignments
-Rating Scale with
rubric
15
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
6.1. Review basic genetic concept.
6.2. Explain the mechanism by which
genetic variations may cause adverse
drug reaction and idiosyncratic reactions
6.3. Discuss and give examples of single-
gene pharmacokinetic disorders.
6.4. Discuss the potential benefits of
Pharmacogenetics.
6.5. Explain the potential benefits of
pharmacogenomics
6.5. Evaluate currently available
pharmacogenomic tests and their
potential benefits .
6.4 Review and critique research paper
on pharmacogenomics
6.6. Present a case of genetic variations
6. Clinical Pharmacology
a.Pharmacogenetics
- genetic variations for drug
reactions , idiosyncratic
reactions
-single gene pharmacokinetic
disorders
b. pharmacogenomics, and
personalized medicine
3.5 hours Small group
discussion
-case studies
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
Rang and Dales
Pharmacology
-Netters Illustrated
Pharmacology
Textbook :
Rang and Dales
Pharmacology
-Netters Illustrated
Pharmacology
graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
-long exam MCQ
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
16
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
1.1. Review and identify the locations
and types of acetylcholine receptors in
the major organ systems (CNS,
autonomic ganglia, eye, heart, vessels,
bronchi, gut, genitourinary tract,
skeletal muscle, exocrine glands).
1.2. Describe the effects of acetylcholine
on the major organs.
1.3 Classify the different Cholinergic
Agonist
1.3. Relate the different
pharmacokinetic properties of the
various choline esters , cholinesterase
inhibitors and cholinomimetic alkaloids
to their chemical properties and
pharmacokinetic profile.
1.4. Explain in detail the mechanism of
action of cholinomimetic / cholinergic
agonist
1.5 Analyze the pharmacologic
differences of direct acting and indirectly
acting cholinomimetic agents
1.4. Recognize naturally occurring
UNIT II
DRUGS ACTING ON THE
AUTONOMIC NERVOUS SYSTEM
1. Cholinergic agonist /
a. Cholinoceptor Activating
drugs
-direct acting cholinergic
agonist
- choline esters
- naturally occurring
Alkaloids
-indirectly acting
-Choline esterase inhibiting
-reversible
-irreversible
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
-Interactive
Lecture
-Small group
discussion
Textbook :
1. Basic and -Clinical
Pharmacology)
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
5. Netter’s Illustrated
Pharmacology
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dale
Pharmacology
-quizzes
-oral recitation
-unit examination
- group
participation and
communication
skills
-short essay
-graded oral
reports
-Unit examination
- group
-Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
-Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
17
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
alkaloids and their botanical sources
1.4. Discuss the major clinical uses of
cholinomimetic agonists.
1.5. Differentiate the pharmacodynamic
of direct-acting and indirect-acting
cholinomimetic agents.
1.6. Recognize the major signs and
symptoms of (1) organophosphate
insecticide poisoning and (2) acute
nicotine toxicity.
1.8.Research and Present local cases of
organophosphate /insecticide poisoning
1.7 Formulate a management plan in
the treatment of organophosphate
insecticide poisoning and give the
rationale for such treatment
1.8 Dessiminate information to
communities on
organophosphate/insecticide poisoning
c. Organophosphate poisoning
-insecticides
-agents use in Chemical Warfare
-case studies 3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
5. Netter’s Illustrated
Pharmacology
participation and
communication
skills
-short essay
assignments
-Minute paper
-Rating Scale with
rubric
18
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
2.1 Discuss the mechanism of action of
antimuscarinics
2.2 Explain effects of atropine on the
major organ system
2.3. Identify the major clinical
indications and contraindications for the
use of muscarinic antagonists
2.4.Recognize naturally occurring
antimuscarinic agents and their
botanical sources
2.4. Classify the different muscarininc
agent promoted for each uses : to
produce mydriasis cycloplegia , to treat
parkinsons, peptic ulcer and asthma
2.6. Describe the signs ,symptoms and
treatmernt of atropine poisoning
2.7 Present a case of poisoning due to
atropine or other naturally occurring
antimuscarinic alkaloid especially in the
Philippine setting
2.8. Formulate a treatment plan in cases
of poisoning of atropine and give the
rationale of the antidote
2. Cholinoceptor Blockers
a. Antimuscarinics
3.5 hours
Interactive
Lecture
-Small group
discussion
-case studies
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
5. Netter’s Illustrated
Pharmacology
-quizzes
-oral recitation
-graded oral
reports
-Unit examination
- participation and
communication
skills
-short essays
-Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
19
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
2.9.Dessimiate information of the
toxicity of naturally occurring
antimuscarinic alkaloids.
2.5. Explain the mechanism of action
and effects of the ganglionic blocking
nicotinic antagonist
2.6 Conduct an information drive of the
ill effects of nicotine.
b. Ganglionic blocking nicotinic
antagonist
3.1. Discuss the transmission process at
the neuromuscular end plate and the
points at which drugs can modify this
process.
3.2. Identify the major nondepolarizing
neuromuscular blockers and one
depolarizing neuromuscular blocker;
compare their pharmacokinetics.
3.3. Compare the difference between
depolarizing and nondepolarizing
blockers from the standpoint of tetanic
and posttetanic twitch strength.
3.4. Describe the method of reversal of
3. Skeletal Muscle Relaxants
- Neuromuscular blocking
agents
-direct acting skeletal muscle
relaxant
-centrally acting skeletal muscle
relaxant
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
5. Netter’s Illustrated
Pharmacology
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
-Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
20
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
nondepolarizing blockade.
3.5. Explain the mechanism of action of
the major drugs used in the treatment
acute and chronic skeletal muscle
spasticity and describe their
mechanisms.
4.1. List tissues that contain significant numbers of alpha receptors of the ᾳ1, ᾳ2, types. 4.2. List tissues that contain significant numbers of β1 or β2 receptors. 4..3. Describe the major organ system effects of a pure alpha agonist, a pure beta agonist, and a mixed alpha and beta agonist. Give examples of each type of drug. 4..4. Describe a clinical situation in which the effects of an indirect sympathomimetic would differ from those of a direct agonist. 4.5. List the major clinical application of the adrenoceptor agonist. 4.6 . Compare the different sympathomimetics according to: 4.6.1. Mechanism of action
4. Sympathomimetics
-direct acting
sympathomimetic
-indirectly acting
sympathomimetic
-mixed acting
sympathomimetic
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
21
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
4.6.2. Clinical Application 4.6.3. Pharmacokinetics 4.6.4 Toxicities and Drug Interaction 4.7. Present a case of the effect of sympathomimetics of vascular resistance, blood pressure and heart rate.
5.1 Discuss the effects of an alpha
blocker
5.2 Discuss the effects of a beta blocker
5.3 compare the effects of the different
beta blockers
5.4 compare the pharmacokinetics of
the different beta blockers
5.5 describe the clinical indications and
toxicities of alpha and a beta blockers
5.6 Present a case of hypertension using
the different kinds of adrenoceptor
blockers
5. adrenoceptor
blockers
-Alpha blockers
(selective and non-selective)
-Beta blockers (selective and
non-selective)
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
-long exam MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
22
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
1.1. Classify the major types of diuretics and relate them to their sites of action. 1.2. Explain two drugs that reduce potassium loss during sodium dieresis. 1.3. Discuss a therapy that will reduce calcium excretion in patients who have recurrent urinary stones. 1.4. Discuss a treatment for severe hypercalcemia in a patient with advance carcinoma. 1.5. Explain a method for reducing urine volume in nephrogenic diabetes insipidus. 1.6. List the major applications and the toxicities of thiazides, loop diuretics, and potassium-sparing diuretics.
UNIT III
CARDIOVASCULAR DRUG
1. Diuretic Drug
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
23
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
2.1. Classify the four major groups of
antihypertensive drugs and give
examples of drugs in each group.
2.2. Explain the compensatory responses
to each of the four major types of
antihypertensive drugs.
2.3. Classify the major sites of action of
sympathoplegic
drugs and give examples of drugs that
act at each site.
2.4. Classify the three mechanism of
action of vasodilator drugs.
2.5. Discuss the differences between the
two types of angiotensin antagonist
2.6. List the major toxicities of the
prototype antihypertensive agents.
2.7. Explain why some combinations of
Antihypertensive drugs are rational and
appropriate and others are not.
2.8. Critic a journal of hypertensive case
reports
2.9. Present a case of hypertension.
2.10. Formulate a drug management in a
2. Drugs used in Hypertension
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
Philippine
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
24
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
hypertensive patient
2.11. Attend a seminar on the
management of hypertension
3.1. Discuss the pathophysiology of
effort angina and
vasospastic angina.
3.2. Explain the major determinants of
cardiac oxygen consumotion.
3.3. Discuss the strategies for relief of
angina pain.
3.4. Contrast the therapeutic and
3. Vasodilators and the
Treatment of Angina
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
-quizzes
-oral recitation
-graded oral
reports
-Unit examination
-participation and
communication
skills
Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
25
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
adverse effect of nitrates, beta-blockers,
and calcium channel blockers when used
for angina.
3.5. Explain why the combination of a
nitrate with a beta-blocker or a calcium
channel blocker may be more effective
than either alone.
3.6. Explain why the combination of a
nitrate and sildenafil is potentially
dangerous.
3.7. Contrast the effects of medical
therapy and surgical therapy of angina.
3.8. Attend a drug symposium involving
treatment of angina
3.9. Conduct a community seminar
regarding the cause and prevention of
angina
3.5 hours
Illustrated Reviews:
Pharmacology
-short essays
4.1. Discuss the strategies and list the
major drug groups used in the treatment
of congestive heart failure.
4.2. Explain the probable mechanism of
action of digitalis.
4.Drugs used in treatment of
congestive heart failure
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
-graded oral
reports
-Unit examination
-participation and
- Posttest MCQ
- Essay questions --
-Embedded testing
incorporated into
26
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
4.3. Explain the nature and mechanism
of digitalis’s toxic effects on the heart.
4.4. List some positive inortropic drugs
that have been invested as digitalis
substitutes.
4.5. Discuss the beneficial effects of
diuretics, vasodilators, ACE inhibitors,
and other drugs that lack positive
inortropic effects in congestive heart
failure.
4.6. Present a case of congestive heart
failure
4.7. Formulate different management
strategies in the management of
congestive heart failure
Philippine
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
5. Netter’s Illustrated
Pharmacology
communication
skills
-short essays
assignments
-Minute paper
-Rating Scale with
rubric
5.1. Explain the distinguishing features
of the four major classes of
antiarrhythmic drugs and adenosine.
5.2. List two or three of the most
important drugs i each of the four
classes.
5.3. List the major toxicities of those
drugs.
5. Antiarrhythmic Drugs
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
graded oral
reports
-Unit examination
- group
participation and
communication
skills
-Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
27
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
5.4. Discuss the mechanism of selective
depression by local anesthetic
antiarrhythmic agents.
5.5. Explain how hyperkalemia,
hypokalemia, or an antiarrhythmic drug
can cause an antihythmia
Illustrated Reviews:
Pharmacology
5. Netter’s Illustrated
Pharmacology
-short essay
6.1. Review the proposed role of
lipoproteins in the formation of
atherosclerotic plaques.
6.2. Discuss the dietary management of
hyperlipoproteinemia.
6.3. Classify the four main classes of
drugs used to treat hyperlipidemia and
describe their mechanism of action,
effects upon serum lipid concentration,
and adverse effects.
6.4. Propose a rational drug treatment
regimen based on a set of baseline
serum lipid values.
6.5. Collaborate with professional the
merits of combined drug therapy for
hyperlipedemia.
6.6. Educate patients on hyperlipidemias
6. Drugs used in the
treatment of
Hyperlipidemias
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
-Role playing
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
5. Netter’s Illustrated
Pharmacology
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
28
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
7.1.Classify the major classes of
anticlotting drugs and compare their
utility in venous and arterial
thromboses.
7.2. Discuss the four types of
anticoangulants and their mechanisms
of action.
7.3. Explain why the onset of
warfarin’saction is relatively slow.
7.4. Compare the oral anticoangulants,
standard heparin, and low-molecular-
weight heparins in terms of their
pharmacokinetics, mechanisms, and
toxicities.
7.5. Give several examples of warfarin’s
role in pharmacodynamic drug
interactions.
7.6. Diagram the role of activated
platelets at the Site of a damaged blood
vessel wall and show where the major
four classes of antiplatelet drugs act.
7.7. Compare the pharmacokinetics,
clinical uses and toxicity of the major
7. Drugs Used in Coangulation
disorders
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
5. Netter’s Illustrated
Pharmacology
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
-long exam MCQ
29
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
antiplatelet drugs.
7.8. Classify the different drugs used to
treat Disorders of excessive bleeding.
1.1. Review the major organ system
effects of histamine and serotonin.
1.2. Discuss the pharmacology of the
two generations and three subgroups of
H1 antihistamines; list prototypical
agents for each subgroup.
1.3. Explain the pharmacology of H2
antihistamines; identify the four
members of this group.
1.4. Discuss the action, indication, and
toxicity of sumatripan.
1.5. Discuss one 5-HT2 and one 5-HT3
antagonist and their major applications.
1.6. Anticipate the major organ system
effects of the ergot alkaloids.
1.7. Discuss the major clinical
applications and toxicities of the ergot
drugs.
1.8. Critically appraised relevant
literatures regarding the use of ergot
UNIT IV
AUTOCOIDS AND DRUG WITH
IMPORTANT ACTIONS ON
INFLAMMATION
1. Histamine, Serotonin, and the
Ergot Alkaloids
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
Philippine
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
graded oral
reports
-Unit examination
- group
participation and
communication
Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
30
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
alkaloids.
1.9. Formulate an inventory of health
diseases associated with histamine , etc.
and give the plan of management.
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
skills
-short essay
-Minute paper
-Rating Scale with
rubric
2.1. Name an antagonist of angiotensin
at its receptor and at least two drugs
that reduce the formation of angiotensin
II.
2.2. Outline the major effects of
bradykinin and atrial natriuretic peptide.
2.3. Discuss the functions of converting
enzyme(peptidyl dipeptidase, kininase
II).
2.4. Compare two potent
vasoconstrictor peptides based on their
pharmacokinetics.
2.5. Discuss the effects of vasoactive
intestinal peptide, substance P, and
calcitonin gene-related peptide.
2.Vasoactive Peptides 3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
5. Netter’s Illustrated
Pharmacology
graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
3.1. Review the major effects of PGE2
PGF2ἀ, LTB4, LTC4, and LTD4.
3.2. Discuss the synthesis and the effects
3. Prostaglandins and other
Eicosanoids
3.5 hours
-Interactive
Lecture
-Small group
Textbook :
1. Basic and -Clinical
Pharmacology
graded oral
reports
- Posttest MCQ,
-Essay questions
31
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
of thromboxane and prostacyclin in the
vascular system.
3.3. Categorized the currently available
therapeutic antagonists of leukotrienes
and prostaglandins and their targets
(receptors or enzyme).
3.4. Explain the different effects of
aspirin on prostaglandin synthesis and
on leukotriene synthesis.
discussion
-case studies
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
5. Netter’s Illustrated
Pharmacology
-Unit examination
- group
participation and
communication
skills
-short essay
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
4.1. Review the enzyme responsible for
the synthesis of nitric oxide in tissues.
4.2. Identify the major beneficial and
toxic effects of endogenous nitric oxide.
4.3. Explain two drugs that cause release
of endogenous nitric oxide.
4.4. Discuss two drugs that
spontaneously or enzymatically break
down in the body to release nitric oxide
.
4. Nitric Oxide, Donors , and
Inhibitors
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
5.1. Contrast the functions of COX-1 and
COX-2.
5.2. Discuss the effects of aspirin and
5. Nonsteroidal Anti-
inflammatory Drugs,
Acetaminophen, and Drugs
3.5 hours
-Interactive
Lecture
-Small group
Textbook :
1. Basic and -Clinical
Pharmacology
-graded oral
reports
-Essay questions
32
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
other NSAID on prostaglandin synthesis.
5.3. Contrast the actions and toxicity of
aspirin, the older nonselective NSAIDS
and the COX-2-selective drugs.
5.4. Identify the toxic effects of aspirin.
5.5. Classify the different DMARDs and
compare their mechanism of action and
toxicity with those of the NSAIDs.
5.6. Contrast the treatment of acute and
chronic Gout.
5.7. Discuss the mechanism of action
and toxicity of three different drug
groups used in gout.
5.8. Explain the effects and the major
toxicity of acetaminophen and its
treatment.
5.9. Critically appraised relevant
literature on NSAID.
5.10. Educate patients and family
regarding prognosis and management of
the different kind of arthritis.
5.11.Promote in the community in
collaboration with LGUs the use of
Used in Gout
discussion
-case studies
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
-Unit examination
- group
participation and
communication
skills
-short essay
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
-long exam MCQ
33
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
natural plants available for the
treatment of anti-inflammatory
conditions.
1.1. Identify the major types of voltage-
gated and ligand-gated ion channels in
neuronal membranes.
1.2. Categorized the criteria for
accepting a chemical as a
neurotransmitter.
1.3. Discuss the mechanism by which
drugs module synaptic transmission.
1.4. Categorized the major excitatory
and major inhibitory central
eurotransmitters.
1.5. Identify the major receptor
subtypes of CNS neurotransmitters.
UNIT V
DRUGS THAT ACT IN THE
CENTRAL NERVOUS SYSTEM
1. Introduction to CNS
Pharmacology
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
2.1. Categorized the major chemical
classes of sedative-hypnotics.
2.2. Discuss the pharmacodynamics of
benzodiazepines and barbiturates,
including their mechanisms of action.
2.3. Compare the pharmacokinetics of
commonly used benzodiazepines and
2.A. Sedative-Hypnotic Drugs
-Barbiturates
-Benzodiazepines
- “Z” drugs
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
-graded oral
reports
-Unit examination
- group
participation and
communication
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
34
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
barbiturates and discuss how differences
among them affect clinical use.
2.4. Explain the clinical uses and adverse
effects of sedative-hypnotics.
2.5. Compare the distinctive properties
of buspirone, zolpidem, and zaleplon.
2.6. Classify the different anti-anxiety
agents.
2.7. Compare the pharmacokinetic of
the different anti-anxiety agent.
2.8. Critically appraised research
literatures regarding the
benzodiazepines and other drugs used
as hypnotic agents.
2.9. Conduct a research on endogenous
plants that have potential sedative
hypnotic property.
2.B. Anti-anxiety agents
3.5 hours
10 hours
-Interactive
Lecture
-Small group
discussion
-case studies
-Laboratory
researches
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
skills
-short essay
-quizzes
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
-Rating Scale with
rubric
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
3.1. Classify the major drugs used for partial seizures, generalized tonic-clonic seizures, absence and myoclonic seizures, and status epilepticus. 3.2. Explain the mechanisms of
3. Antiseizure / Antiepileptic
agents
3.5 hours
-Interactive
Lecture
-Small group
discussion
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
-quizzes
- graded oral
reports
-Unit examination
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
35
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
antiseizure drug action. 3.3. Discuss the main pharmacokinetics and adverse effects of major antiseizure drugs. 3.4. Identify new antiseizure drugs and their important characteristics. 3.5. Explain the factors that must be considered in designing a dosage regimen for an antiseizure drug.
-case studies Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
- group
participation and
communication
skills
-short essay
assignments
-Minute paper
-Rating Scale with
rubric
4.1. Classify the main inhalation
anesthetic agents and describe their
pharmacodynamics properties.
4.2. Discuss the relationship of the
blood: gas partition coefficient of an
inhalation anesthetic with its speed of
onset of anesthesia and its recovery
time.
4.3. State the factors that influence
inhalation anesthetic biodisposition.
4.4. Discuss the main pharmacokinetic
and pharmacodynamic characteristics of
the intravenous anesthetics.
4. General Anesthetics
-Inhalational general
anesthetics
-Intravenous general
anesthetics
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
- graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
36
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
5.1.Discuss the mechanism of blockade
of the nerve impulses by local
anesthetics
5.2. Discuss the relationship between
pH, pKa, and the speed of onset of local
anesthetics.
5.3. Summarize the factors that
determine the susceptibility of nerve
fibers to blockade.
5.4. List the major toxic effects of the
local anesthetics.
5.5. Explain use-dependent blockade by
local anesthetics.
5. Local Anesthetics
-Esters Local Anesthetics
-Amides Local Anesthetics
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
37
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
6.1. Discuss the neurochemical
imbalance underlying the
symptoms of parkinson’s disease.
6.2. Explain the mechanisms by which
levodopa, dopamine receptor agonists,
selegiline, and muscarinic blocking drugs
alleviate parkinsonism.
6.3. Discuss the therapeutic and toxic
effects of the major antiparkisonism
agents.
6.4. Identify the compounds that inhibit
dopa decarboxylase and catechol-O-
methyltransferase and muscarinic
blocking drugs alleviate parkinsonism.
6.5. Identify the chemical agents and
drug that cause parkinsonism
symptoms.
6.6. Identify the drugs used in
management of tremor, Hungtington’s
disease, drug-induced dyskinesias, and
Wilson’s disease.
6.7. Critically appraised relevant
research literature of the new
6. Drugs used in Parkinsonism
and other movement Disorders.
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
5. Netter’s illustrated
Pharmacology
-quizzes
--graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
38
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
modalities.
6.8. Attend seminars regarding
Parkinson’s disease and management.
3.5 hours
7.1. Discuss the pharmacodynamics of
older antipsychotic drugs and relate
7. Antipsychotic Drugs and
3.5 hours
-Interactive
Lecture
Textbook :
1. Basic and -Clinical
-quizzes
-oral recitation
- Posttest MCQ,
-Essay questions
39
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
these characteristics to their clinical
uses.
7.2. Compare and identify the main
characteristics and clinical uses of newer
atypical antipsychotic drugs.
7.3. List the major adverse of the
antipsychotic drugs.
7.4. Explain the pharmacokinetics and
pharmacodynamics of lithium.
Lithium
-Small group
discussion
-case studies
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
8.1. Explain the probable mechanism
and the major properties of tricylic
antidepressants.
8.2. Discuss the toxic effects that occur
during chronic therapy and with an
acute overdose of tricyclic
antidepressants.
8.3. Identify the second-and third-
generation heterocyclic antidepressants
and their distinctive properties.
8.4. Contrast and identify the selective
serotonin reuptake inhibitors and list
their major characteristics.
8. Antidepressants
-Tricyclic Antidepressants
(TCA)
-Heterocyclic Antidepressants
-Monoamine oxidase Inhibitors
-Selective Serotonine
Re-uptake Inhibitors (SSRI)
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
40
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
8.5. Discuss the therapeutic use and
toxic effects Of MOA inhibitors
8.6. Identify the major drug interactions
associated with antidepressant drugs.
8.7. Present a case study of depression
and its treatment.
8.9. Educate family and patient who has
depression regarding the prognosis,
management.
8.10. Formulate health and wellness
plan for patients with depression.
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
9.1.Review the endogenous opioid
peptides.
9.2. List the receptors activated by
opioid analgesics and the endogenous
opioid peptides.
9.3. Categorize the major opioid
agonists according to thier analgesic
9. Opioid Analgesics and
Antagonists
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
-graded oral
reports
-Unit examination
- group
participation and
communication
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
41
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
efficacy.
9.4. Differentiate the effects opioid
receptor antagonists and mixed agonist-
antagonists.
9.5. Discuss the main pharmacodynamic
and pharmacokinetics properties of
agonist opioid analgesics and list their
clinical uses.
9.6. Compare the main adverse effects
of acute and chronic use of opioid
analgesics.
9.7. Discuss the clinical uses of the
opioid receptor antagonists.
9.8. List two opioids used for antitussive
effects and one used for antidiarrheal
effects.
9.9 Explain the different government
requirement sin prescribing a narcotic
-Interactive
Lecture
-Small group
discussion
-case studies
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
Philippine
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
skills
-short essay
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
-Rating Scale with
rubric
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
10.1. Discuss the pharmacodynamics
and pharmacokinetics of acute ethanol
10. Alcohols
3.5 hours
-Interactive
Lecture
Textbook :
1. Basic and -Clinical
- quizzes
-graded oral
- Posttest MCQ,
-Essay questions
42
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
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STRATEGIES
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Assessment tool
ingestion.
10.2. List the toxic effects of chronic
ethanol ingestion.
10.3 Describe the fetal alcohol
syndrome.
10.4. Discuss the treatment of acute and
chronic ethanol over dosage.
10.5. Outline the pharmacotherapy of
(a) the alcohol withdrawal syndrome
and (b) alcoholism.
10.6. Discuss the mechanism of the
toxicity and treatment of acute
poisoning with (a) methanol and (b)
enthylene glycol.
10.7 Conduct community awareness
programs about the ill effects of alcohol
1,5 hrs
-Small group
discussion
-case studies
Health
education in
the
community
Pharmacology
2. Rang and Dales
Pharmacology
Philippine
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
Textbooks .
Basic and -Clinical
Pharmacology
reports
-Unit examination
- group
participation and
communication
skills
-short essay
Group
participation And
communication
skills
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
Rating Scale with
Rubric
11.1. Classify and describe the major 11. Drugs of Abuse 3.5 hours -Interactive Textbook : -quizzes - Long exam MCQ
43
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
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STRATEGIES
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Assessment tool
actions of drugs that are commonly
abused.
11.2. Describe the major signs and
symptoms of overdose with, and
withdrawal from, CNS stimulants.
11.3. Explain the general principles of
the management of overdose of
commonly abused drugs.
11.4. Identify the most likely causes of
death from commonly abused agents.
11.5 Adhere to Legal standards in the
use of substances of abuse
11.5. Collaborate with different health
professional and NGO’s in conducting
campaign and seminars directed
towards educating the youth about drug
abuse
Lecture
-Small group
discussion
-case studies
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
- -graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
1.1. Review the major hypothalamic releasing hormones. 1.2. Discuss the major anterior pituitary hormones and their effects.
UNIT VII
ENDOCRINE DRUGS
-Interactive
Lecture
-Small group
Textbook :
1. Basic and -Clinical
Pharmacology
-quizzes
--graded oral
reports
- Posttest MCQ,
-Essay questions
-Embedded testing
44
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
1.3. Discuss the major posterior pituitary hormones and their effects. 1.4. Describe the major drugs used as substitutes for the natural hypothalamic and pituitary hormones. 1.5. Identify the drugs that are used for treatment of acromegaly and hyperprolactinemia.
1. Hypothalamic and Pituitary
Hormones
3.5 hours
discussion
-case studies
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
-Unit examination
- group
participation and
communication
skills
-short essay
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
2.1. Identify the principal drugs used in
the treatment of hypothyroidism.
2.2. Identify the principal drugs used in
the treatment of hyperthyroidism and
compare the onset and duration of their
action.
2.3. Sketch the biochemical pathway for
thyroid Hormone synthesis and release
and indicate the sites of action of
antithyroid drugs.
2.4. Discuss the major toxicities of
thyroxine and the antihtyroid drugs.
2.5. Correlate research findings with the
mechanism of action of anti-thyroid
drugs.
2.Thyroid and Antithyroid Drugs
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
-quizzes
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
45
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
2.6. Present a case of hyper and hypo
thyroidism and its management.
2.7. Collaborate with LGUs in conducting
community education regarding thyroid
diseases its prevention and
management.
3.1. Discuss the major naturally
occurring glucocorticosteroid and its
actions.
3.2. Compare several synthetic
glucocorticoids and the differences
between these agents and the naturally
occurring hormone.
3.3. Explain the actions of the naturally
occurring mineralocorticoid and one
synthethic agent in this subgroup.
3.4. List the indications for the use of
corticosteroids in adrenal and
nonadrenal disorders.
3. Corticosteroids and
Antagonist
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
-quizzes
--graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
4.1. Discuss the hormonal changes that
occur during the menstrual cycle.
4.2. Identify three estrogens and four
progestins. Describe their pharmacologic
4. Gonadal Hormones and
Inhibitors
-Female Hormone agonist and
3.5 hours
-Interactive
Lecture
-Small group
discussion
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
-quizzes
-graded oral
reports
-Unit examination
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
46
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
effects, clinical uses, and toxicity.
4.3. List the benefits and hazards of oral
contraceptives.
4.4. List the benefits and hazards of
postmenopausal estrogen therapy.
4.5. Discuss the uses of sex hormones
and their antagonists in the treatment of
cancer in women and men.
4.6. Explain the toxic effects of anabolic
steroids used to build muscle mass.
4.7. Define the terms “SERM” and
“mixed agonists.”
4.8. Compare two SERMS and their
unique properties.
antagonist
-Male Hormone agonist and
antagonist
-case studies Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
- group
participation and
communication
skills
-short essay
assignments
-Minute paper
-Rating Scale with
rubric
5.1. Review the effects of insulin on the
liver, on muscle, and on adipose tissue.
5.2. Compare the types of insulin
preparations and their durations of
action.
5.3. Explain the major hazards of insulin
therapy.
5.4. Discuss the prototypes and their
5. Pancreatic Hormones,
Antidiabetic Agents, and
Hyperglycemic Drugs.
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
-quizzes
- graded oral
reports
-Unit examination
- group
participation and
communication
skills
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
47
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
mechanisms of action, toxicities of the
four major classes of oral antidiabetic
agents.
5.5. Give three examples of rational drug
combinations for treatment of type 2
diabetes mellitus.
5.6. Explain the clinical uses of glucagon.
5.7. Review the epidemiology of
diabetes and obesity in the Philippines.
5.8. Attend seminars and drug symposia
regarding diabetes and new modalities
in treatment.
5.9. Critically appraised relevant
literatures regarding the management
and treatment of diabetes mellitus.
5.10. Conduct community education
regarding the diabetes, prevention and
management options, and prognosis of
the disease.
5.11. Conduct research on endogenous
plant that is useful in the management
of diabetes.
Illustrated Reviews:
Pharmacology
5. Netter’s Illustrated
Pharmacology
6Understanding
Research methods:
An Overview of the
essentials
7. Access to library
and Online library
collections.
-short essay
48
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
6.1. List the agents useful in the
treatment of hypercalcemia.
6.2. Identify the major and minor
regulators of bone mineral homeostasis.
6.3. Discuss the major effects of
parathyroid hormone and vitamin D
derivatives on the intestine, the kidney,
and bone.
6.4. Attend seminars on osteoporosis.
6.5. Conduct community health
education regarding osteoporosis.
6. Drugs that Affect Bone
Mineral Hemeostasis.
3.5 hours
3,5 hours
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
Philippine
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
-quizzes
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
Long exam MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
1.1. Discuss the mechanism of
antibacterial action of beta-lactam
antibiotics.
1.2. Explain the mechanisms underlying
the resistance of bacteria to beta-lactam
antibiotics.
1.3. Identify the four important drugs in
each subclass of penicillins and describe
their antibacterial activity and clinical
uses.
1.4. Identify the four subclasses of
cephalosporins and describe their
UNIT VIII
CHEMOTHERAPEUTIC AGENTS
1. Beta-Lactam Antibiotics
and Other Cell Wall Synthesis
Inhibitors
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
-quizzes
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
49
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
antibacterial activities and clinical uses.
1.5. List the major adverse effects of the
penicillins and the cephalosporins.
1.6. Explain the important features of
aztreonam, imipenem, and meropenem.
1.7. Discuss the clinical uses and
toxicities of vancomycin, fosfomycin,
and bacitracin.
-quizzes
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
2.1. Explain the mechanisms of action of
these inhibitors of bacterial protein
synthesis.
2.2. Explain the mechanisms responsible
for clinical bacterial resistance to these
2. Chloramphenicol,
Tetracyclines, Macrolides,
Clindamycin, Streptogramins,
and Linezolid.
3,5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
-quizzes
-graded oral
reports
-Unit examination
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
50
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
drugs.
2.3. List the major clinical uses of these
drugs.
2.4. Discuss the pharmacokinetics
features of these agents that are most
relevant to their clinical use.
2.5. Identify the main toxic effects of
these drugs.
2.6. Critically appraised relevant
research literature regarding the use of
antibiotics.
3.5 hours
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
5. Internet sources
6. Published
Researches
7. e-Journals
- group
participation and
communication
skills
-short essay
assignments
-Minute paper
-Rating Scale with
rubric
3.1. Explain the mechanism of action of
amino glycosides antibiotics and the
mechanisms by which bacterial
resistance to this class of drugs occurs.
3.2. Identify the major clinical
applications of aminoglycosides and
describe their main toxic effects.
3.3. Discuss the pharmacokinetics of this
drug class, with special reference to the
importance of renal clearance and its
relationship of toxicity.
3. Amino glycosides
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology)
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook (2014)
4.Lippincott
Illustrated Reviews:
Pharmacology(2014)
-quizzes
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
51
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
4.1. Discuss the mechanism of
antibacterial action of sulfonamides and
trimethoprim on bacterial folic acid
synthesis and the mechanisms involved
in bacterial resistance to the antifolate
drugs.
4.2.Identify the major clinical uses of
sulfonamides and trimethoprim, singly
and in combination, and describe their
pharmacokinetic properties and toxic
effects.
4.3. Discuss the mechanisms of action of
the fluoroquinolone antibiotics and the
mechanisms involved in bacterial
resistance to these agents.
4.4. Identify the major clinical uses of
fluoroquinolones and describe their
pharmacokinetic properties and toxic
effects.
4. Sulfonamides, Trimethoprim,
and Fluoroquinolones.
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
5. Netter’s Illustrated
Pharmacology
-quizzes
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
5.1. Explain the special problems
associated with chemotherapy of
mycobacterial infections.
5.2. Discuss the pharmacodynamic and
5. Antimycobacterial Drugs
3.5 hours
-Interactive
Lecture
-Small group
discussion
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
-quizzes
-graded oral
reports
-Unit examination
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
52
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
pharmacokinetic properties of the first-
line drugs used in tuberculosis (isoniazid,
ethambutol, pyrazinamide, rifampin,
and streptomycin).
5.3. Identify the second-line drugs used
in tuberculosis and list their limitations.
5.4. Identify the drugs used in leprosy
and in Atypical mycobacterial diseases
and describe their major toxic effects.
5.5. Critically appraise relevant research
regarding the treatment of tuberculosis
and leprosy.
5.6. Evaluate DOH programs regarding
tuberculosis prevention and treatment.
5.7. Conduct community education
regarding tuberculosis and leprosy, its
impact in the community and its
prevention and treatment.
-case studies Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
5. Netter’s Illustrated
Pharmacology
6. e- journals
7. Published research
8. Internet sources
- group
participation and
communication
skills
-short essay
assignments
-Minute paper
-Rating Scale with
rubric
6.1. Explain the mechanism of action of
the major drugs used for fungal
infections.
6.2. Discuss the clinical uses and
6. Antifungal Agents
3.5 hours
-Interactive
Lecture
-Small group
discussion
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
-quizzes
-graded oral
reports
-Unit examination
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
53
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
pharmacokinetics of amphotericin B,
flucytosine, fluconazole, itraconazole,
ketoconazole, griseofulvin, and
terbinafine.
6.3. Identify the toxic effects of the
major antifungal drugs.
6.4. Identify the main topical antifungal
agents.
-case studies Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
- group
participation and
communication
skills
-short essay
assignments
-Minute paper
-Rating Scale with
rubric
7.1. Identify the main steps in viral
replication.
7.2. Explain the mechanism of action
and of resistance of the major
antiherpes drugs.
7.3. Discuss the pharmacokinetic
properties, the clinical uses, and the
toxic effects of the antiherpes drugs.
7.4. Explain the mechanism of action
and Resistance of the major
antiretroviral drugs.
7.5. Discuss the pharmacokinetic
properties, the clinical uses, and the
toxic effects of the antiretroviral drugs.
7. Antiviral Chemotherapy and
Prophylaxis
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
Philippine
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
5. Netter’s Illustrated
Pharmacology
-quizzes
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
54
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
7.6. Identify the significant antiviral
properties of amanitadine,
neuraminidase, inhibitors, interferons,
and ribavirin.
8.1. Explain the antibacterial actions,
clinical uses and toxicities of
metronidazole, mupirocin, and
polymyxins.
8.2. Compare nitrofurantoin,
methenamine, and nalidixic acid as
urinary antiseptics and describe their
toxic effects.
8.3. Correlate research findings of the
treatment of urinary tract infection with
the mechanism of the disease.
8. Miscellaneous Antimicrobial
Agents and Urinary Antiseptics
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
-quizzes
- -graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
9.1. Analyze the serum drug levels or
bactericidal titers in antimicrobial
chemotherapy.
9.2. Identify the antimicrobial drugs that
require major modifications of dosage
when renal or hepatic function change,
or when dialysis is used.
9.3. Explain the reasons for use of
9. Clinical Use Antimicrobials
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
-quizzes
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
55
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
antimicrobial drugs in comination and
the probable mechanism involved in
drugs synergy.
9.4. Discuss the principles underlying
valid antimicrobial chemopropylaxis and
give examples of commonly used
surgical and nonsurgical prophylaxis.
9.5. Choose the appropriate drug of
choice in certain infections using the
SANE criteria
Illustrated Reviews:
Pharmacology
5. Netter’s Illustrated
Pharmacology
-short essay
10.1. Discuss the mechanism of drugs
whose targets are enzymes unique to
parasites, ie, not found in host cells.
10.2. Explain the mechanisms of drugs
whose targets are enzymes
indispensable to parasites but not to
their hosts.
10.3 Explain the mechanisms of drugs
whose targets are biomedical functions
common to Host and parasites cells.
10. Basic Principles of
Antiparasitic Chemotherapy
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
-quizzes
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
11.1 Classify the major of antiprotozoal
drugs
11. Antiprotozoal Drugs
3.5 hours
-Interactive
Textbook :
-quizzes
- Posttest MCQ,
56
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
11.2. Discuss the pharmacodynamic and
pharmacokinetic properties of the major
antimalarial drugs (chloroquine,
mefloquine, quinine, primaquine, and
the antifolate agents).
11.3. Discuss he pharmacodynamic and
pharmacokinetic properties of the major
anebicides (diloxanide, emetine,
iodoquinol, and metronidazole). List
other clinical applications of
metronidazole.
11.4. Identify the drugs useful for
prophylaxis and treatment of
pneumocytosis and toxoplasmosis and
know their toxic effects.
11.5. Identify the major drugs used for
trypanosomiasis and leishmaniasis and
know their toxic effects.
Lecture
-Small group
discussion
-case studies
-Interactive
Lecture
-Small group
discussion
-case studies
1. Basic and -Clinical
Pharmacology)
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology(2014)
5. Netter’s Illustrated
Pharmacology
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
5. Netter’s Illustrated
Pharmacology
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
-quizzes
-graded oral
reports
-Unit examination
- group
participation and
communication
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
57
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
skills
-short essay
rubric
-long exam MCQ
12.1. Identify the drugs of choice for
treatment of common infections caused
by nematodes, trematodes, and
cestodes.
12.2. Explain the mechanism of action
of the important pharmacokinetic
features, and the major toxic effects of
anthelmintics drugs.
12.3. Differentiate the features of
important anthelmintics.
12.4. Conduct community education
regarding prevention of anthelmintic
disease.
12. Anthelmintic Drugs
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
-quizzes
-quizzes
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
58
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
1.1. Compare the primary features of
cell-mediated and humoral immunity.
1.2. Discuss the different
immunosuppressants and describe the
mechanism of action, clinical uses, and
toxicities.
1.3. Discuss the mechanism of action,
clinical uses, and toxicities and
antibodies used as
immunosuppressants.
1.4. Identify the major cytokines and
other immunomodulating agents and
know their clinical applications.
UNIT IX
Immunopharmacology
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
-quizzes
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
2.1. Discuss the relevance of cell cycle
kinetics to the modes of action and
clinical uses of anticancer drugs.
2.2. Classify the major subclasses of
anticancer drugs, and explain the
mechanisms of action of the main drugs
in each subclass, and describe the
2.Cancer Chemotherapy
3.5 hours
Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
-quizzes
-graded oral
reports
-Unit examination
- group
participation and
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
59
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
mechanism by which tumor cells
develop drug resistance.
2.3.Select the drugs used in regimens for
treatment of the more common
neoplastic diseases and describe their
pharmacokinetics and their toxic effects.
2.4. Explain the rationale underlying the
strategies of combination drug
chemotherapy and rescue therapies.
2.5. Observe the administration of
anticancer agents in a clinical setting
2.6. Critique a research paper in the
therapy of different cancer using new
and modern modalities of treatment
2.7. Attend symposium regarding cancer
and its treatment.
2.8. Conduct awareness of the different
kinds of cancer.
-Interactive
Lecture
-Small group
discussion
-case studies
-Conferences
-Symposiums
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
5. Symposium
speakers
communication
skills
-short essay
-quizzes
-oral recitation
-quizzes
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
-Rating Scale with
rubric
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
-long exam MCQ
60
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
1.1. Identify the major air pollutants and
their clinical effects.
1.2. Identify the major toxicities of
common solvents and insecticides,
including chlorinated hydrocarbons,
inhibitors of cholinesterase, and
botanicals.
1.3.Identify two important herbicides
and their major toxicities.
1.4. Discuss the toxicologic significance of environmental pollution due to dioxins and polychlorinated biphenyls (PCBs).
UNIT X
TOXICOLOGY
1. Introduction to Toxicology
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology)
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
5. Toxicology
Handbook
-quizzes
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
2.1. Discuss the general mechanism of
metal chelation.
2.2. Identify the clinical useful chelators
and know their indications and their
adverse effects.
2.3. Explain the major clinical features
and treatment of acute and chronic lead
poisoning.
2.4. Discuss the major clinical features
and treatment of arsenic poisoning.
2.5. Explain the major clinical features
2. Heavy Metals
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
5. Toxicology
-quizzes
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
61
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
and treatment of inorganic and organic
mercury poisoning.
2.6. Discuss the major clinical features
and treatment of iron poisoning.
Handbook
3.1. Diagrams the steps in the
management of the poisoned patient,
including the emergency treatment of a
comatose patient.
3.2. Identify toxic syndromes associated
with major drug groups and individual
agents frequently involved in poisoning.
3.3. Explain the methods for
identification of toxic compounds,
including physical symptoms and
laboratory methods.
3.4. Discuss the methods available for
decontamination of poisoned patients
and for increasing the elimination of
toxic compounds.
3.5. Identify the antidotes available for
management of poisoning.
3.6. Solve a clinical case of poisoning.
3. Management of the poisoned
Patient
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
5. Toxicology
Handbook
-quizzes
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
-long exam MCQ
Analytical problem
solving assessment
tool
1.1. Discuss the primary UNIT XI -Interactive Textbook :
62
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
pharmacokinetic mechanisms that that
underlie drug interactions.
1.2. Explain how the pharmacodynamics
characteristics of different drugs
administered concomitantly may lead to
additive, synergistic, or antagonist
effects.
1.3. Identify specific drug interactions
that occur commonly in clinical practice.
1.4. Present a case involving drug-to-
drug interaction.
1.5. Critically appraise relevant research
and journals regarding drug interaction.
SPECIAL TOPICS
1. Drug to Drug Interactions
3.5 hours
Lecture
-Small group
discussion
-case studies
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
Philippine
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
5. Principles of
Pharmacology: the
Pathophysiologic
Basis of Drugs
-quizzes
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
2.1. Review the marketing and
governmental regulations of efficacy and
safety botanical and nutritional
supplements
2.2. Evaluate the medicinal value of
substances that has been demonstrated
in controlled clinical studies.
2.3. Identify the most widely used
botanical products locally and globally,
2. Botanical Medications and
Nutritional Supplements
3.5 hours
-Interactive
Lecture
-Small group
discussion
-case studies
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
Philippine
3.Pharmacotherapy
Casebook
4.Lippincott
-quizzes
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
63
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
and describe their purported medical
uses, adverse effects, and potential for
drug interactions.
2.4. Discuss the proposed medical uses
and adverse effects to
dehydroepiandrosterone and melatonin.
2.5. Conduct research on locally
available natural plants and marine life.
Illustrated Reviews:
Pharmacology
5. A Beginners Guide
to Medicinal Plants
6. e –journals
7. Published research
-short essay
3.1. Discuss the principles behind the
different alternative medicine.
3.1.1. Homeopathy
3.1.2. Chelation
3.1.3. Ozone
3.1.4. Acupuncture
3.2. Discuss and describe traditional
Chinese medicine.
3.3. Discuss ayuverdic medicine.
3.4. Explain the principle behind
nutritional medicine, electromagnetic
medicine and light therapy.
3.5. List the ten DOH approved herbal
medicine and their approved uses.
3. Alternative Medicine
- Homeopathy
- Chelation
- Ozone
- Acupuncture
-Traditional Chinese Medicine
-Ayuverdic Medicine
-Nutritional Medicine
-Mind and Body Medicine
-Spiritual Medicine
-Herbal Medicine
-Traditional Filipino Medicine
5 hours
5 hours
Interactive
Lecture
-Small group
discussion
-case studies
-Symposiums
on alternative
medicine
Textbook :
1. Basic and -Clinical
Pharmacology
2. Rang and Dales
Pharmacology
3.Pharmacotherapy
Casebook
4.Lippincott
Illustrated Reviews:
Pharmacology
5. Fundamentals of
Complementary and
Alternative Medicine
6. Resource speakers
-quizzes
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
- Posttest MCQ,
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-Rating Scale with
rubric
64
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
3.6. Explain the evolution of alternative
medicine in the Philippines setting.
3.7. Demonstrate the following :
3.7.1. Qi Gong
3.7.2. Tai Chi
3.7.3. Yoga
3.7.4. Filipino massage (hilot)
3.7.5. Thai massage
3.8. Explain the principle behind Mind
and Body medicine.
3.9. Analyze and explain the connection
between Spirituality and Medicine.
3.10. Critically appraised research
literatures regarding alternative
medicine.
3.11. Conduct research on alternative
medicine.
3.12. Attend seminars on alternative
medicines
3.13. Adhere to ethical and professional
practice of alternative medicine.
3.14. Collaborate with health
professional practicing alternative
5 hours
40 HRS
-Interactive
Lecture
-Small group
discussion
-case studies
-Symposiums
on alternative
medicine
on alternative
medicine
symposiums
7. e-journals
8. Published research
9.Medical Research
Essentials
10. Understanding
Research methods:
An Overview of the
essentials
11. Access to library
and Online library
collections.
12. Symposium
speakers
-quizzes
-graded oral
reports
-Unit examination
- group
participation and
communication
skills
-short essay
Research
-Essay questions
-Embedded testing
incorporated into
assignments
-Minute paper
-long exam MCQ
-Rating Scale with
65
Unit Learning Outcome Topic Outline TIME
FRAME
TEACHING –
LEARNING
STRATEGIES
Resources Assessment Task
Assessment tool
medicine.
3.15. Conduct symposium regarding
alternative medicine.
presentations
rubric
Self reflection
VIII. GRADING SYSTEM :
66
There will be four Bimonthly examinations throughout the school year and two Comprehensive examinations. In each Bimonthly Period a grade will be released which is computed as follows . A) Lecture : Average of quizzes 40% Average of Unit examinations 30% Bi-Monthly exam score 30% B) Laboratory: Quizzes 20% Reporting 25% Group Discussions 25% Oral Examination 30% C) Research : 100% Other activities – conducting symposium 30% Computation of B-Monthly Grade will be as follows : 60% will be taken from the Lecture score ,while the laboratory score comprises 40% Computation of Semestral Grade will be as follows:
67
A) First semester Grade : 80% will be taken from the First and Second Bi-monthly grade, while 20% will be taken from the First semester comprehensive examination . B) Second semester Grade : 80% will be taken from the third and fourth Bimonthly grade , while 20 % will be taken from the Second semester comprehensive examination Computation of Final Grade will be as follows : A) Average of the First and Second semester Grade 70% B) Research Grade 30% ____ Total 100 % No Special Examination will be given if there is no valid reason ( see student manual for reference ) and an excuse letter must be submitted duly signed by the dean . Oral examination will be given to students who missed small or large group discussions . Passing Grade is 70% , students with borderline grade ( 67- 69%) will be given an Oral Examination. Students with grades of 66- 69 will be deliberated. Those with grades of 65 % and below will no longer be deliberated but will be given a grade of 5.0 ( Failed) References
68
Main Textbook Basic and Clinical Pharmacology
By : Katzung, B. G.; Masters, S. B.; Trevor, A. J. (13th edition - 2015)
Other References 1. Goodman and Gilman’s The Pharmacological Basis of Therapeutic 12th edition (2011) By: Brunton, Lawrence; Chabner, Bruce; Knoliman, Bjorn 2. Rang and Dales Pharmacology Philippine Edition (2014) By: Rang, H. P.; Dale, M.M.; Ritter, J.M.; Flower, R.J.; Henderson, G. 3. Pharmacotherapy A Pathophysiologic Approach 9th edition (Feb. 2014) By: Di Prico, Joseph; Talbert, Robert; Yee, Gary; Wells, Barbara 4.Pharmacotherapy Casebook : A Patient- Focused Approach 9th Edition (April 2014)
By: Schwinghammer, Terry; Koehler, Julia
5. Lippincott Illustrated Reviews : Pharmacology 6th Edition (August 2014) By: Walen, Karen 6. Principles of Pharmacology : The Pathophysiologic Basis of Drugs 3rd Edition By: Golan, David; Tashijan, Amen Jr. H.; Armstrong, E.J. 7. Toxicology Handbook (January 2011) By: Murray, Lindsy; Little, Mark 8. Medical Prescription Writing: A Prescription for Clarity (Aug 2014) By: Goodman, Neville ; Edwards
69
9. Netters Illustrated Pharmacology (2014) By: Robert Raffa
10. Rational Use of Drugs (2010) By: WHO International Compilation 11. Fundamentals of Complementary and Alternative Medicine (April 2010) By: Micozzi, Marc 12. A Beginners Guide to Medicinal Plants: Top 10 Medicinal Plants and Herbs; Their Health Benefit and Use (Feb 2015) By: Jones Michael 13. Medical Research Essentials (Dec 2013) By: Estetie, Rania 14. Understanding Research Methods: An Overview the Essential (Nov 2013) By: Patter, Mildred 15. Basic Allied Health Statistics and Analysis (March 2014) By: Koch, Gerda 16. Study Design and Statiscal Analysis: A Practical Guide for Clinicians (Jul 2006) By: Katz, Mitchell 17. Pharmacology Integrated Review (2012) By: Mark Kester
Prepared by : ARLENE M .DIAZ M.D, FPSECP. Ed.D CHAIRMAN